MYL6P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.35198031
2cytidine metabolic process (GO:0046087)9.35198031
3cytidine catabolic process (GO:0006216)9.35198031
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.51815063
5DNA deamination (GO:0045006)8.33349810
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.20052521
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.26179713
8regulation of regulatory T cell differentiation (GO:0045589)4.93230468
9actin nucleation (GO:0045010)4.88775999
10positive T cell selection (GO:0043368)4.82290608
11positive thymic T cell selection (GO:0045059)4.74555508
12negative regulation of T cell apoptotic process (GO:0070233)4.60229959
13eosinophil chemotaxis (GO:0048245)4.55495967
14negative regulation by host of viral transcription (GO:0043922)4.37013965
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25397438
16sequestering of actin monomers (GO:0042989)4.24546671
17positive regulation of interleukin-8 secretion (GO:2000484)4.22978757
18positive regulation of calcium-mediated signaling (GO:0050850)4.15538658
19eosinophil migration (GO:0072677)4.12878086
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11523466
21cytolysis (GO:0019835)4.07099729
22pyrimidine nucleoside catabolic process (GO:0046135)3.99872067
23positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.99168921
24positive regulation of natural killer cell mediated immunity (GO:0002717)3.97529710
25regulation of T cell tolerance induction (GO:0002664)3.87808463
26negative regulation of viral genome replication (GO:0045071)3.83512950
27cellular response to interleukin-15 (GO:0071350)3.83454299
28macrophage chemotaxis (GO:0048246)3.82760740
29positive regulation of gamma-delta T cell activation (GO:0046645)3.80293368
30ATP synthesis coupled proton transport (GO:0015986)3.79713038
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79713038
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79187584
33positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.77733033
34regulation of activation of Janus kinase activity (GO:0010533)3.75044932
35positive regulation of tolerance induction (GO:0002645)3.75014458
36negative T cell selection (GO:0043383)3.72828486
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69804025
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69804025
39platelet dense granule organization (GO:0060155)3.62776786
40T cell migration (GO:0072678)3.60699224
41protein neddylation (GO:0045116)3.54716215
42regulation of gamma-delta T cell differentiation (GO:0045586)3.52655934
43respiratory electron transport chain (GO:0022904)3.46613217
44regulation of T cell receptor signaling pathway (GO:0050856)3.45677780
45T cell costimulation (GO:0031295)3.45051036
46regulation of cellular amino acid metabolic process (GO:0006521)3.44901341
47regulation of lymphocyte chemotaxis (GO:1901623)3.43332907
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41090666
49lymphocyte costimulation (GO:0031294)3.40890075
50electron transport chain (GO:0022900)3.40876885
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40214216
52regulation of interleukin-8 secretion (GO:2000482)3.37858846
53T cell receptor signaling pathway (GO:0050852)3.36907083
54negative regulation of lymphocyte apoptotic process (GO:0070229)3.36761524
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36043631
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.35278253
57regulation of natural killer cell mediated immunity (GO:0002715)3.33039192
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33039192
59positive regulation of defense response to virus by host (GO:0002230)3.32295832
60positive regulation of cell killing (GO:0031343)3.30083968
61regulation of B cell receptor signaling pathway (GO:0050855)3.29030614
62thymic T cell selection (GO:0045061)3.28572170
63regulation of chronic inflammatory response (GO:0002676)3.28280781
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26358848
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17598858
66regulation of tolerance induction (GO:0002643)3.16184597
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13941785
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13941785
69positive regulation of lymphocyte migration (GO:2000403)3.13859662
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13483230
71positive regulation of lamellipodium assembly (GO:0010592)3.13440966
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12000768
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12000768
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12000768
75regulation of T cell apoptotic process (GO:0070232)3.09051956
76negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08841545
77regulation of calcium-mediated signaling (GO:0050848)3.06965993
78regulation of T cell mediated cytotoxicity (GO:0001914)3.06043300
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05826955
80positive regulation of monocyte chemotaxis (GO:0090026)3.04693757
81response to interleukin-15 (GO:0070672)3.04038668
82response to interferon-beta (GO:0035456)3.01127108
83proteasome assembly (GO:0043248)3.00610523
84T cell selection (GO:0045058)2.99819979
85regulation of cell killing (GO:0031341)2.99415239
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.96602158
87positive regulation of B cell differentiation (GO:0045579)2.96071543
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.93945745
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93945745
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92985800
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.88569312
92regulation of B cell differentiation (GO:0045577)2.88277433
93antigen receptor-mediated signaling pathway (GO:0050851)2.86373045
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83536240
95positive regulation of interleukin-4 production (GO:0032753)2.82261196
96regulation of viral genome replication (GO:0045069)2.80354846
97immunoglobulin mediated immune response (GO:0016064)2.79719525
98negative regulation of ligase activity (GO:0051352)2.79525029
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79525029
100lymphocyte chemotaxis (GO:0048247)2.78420782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.35088948
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.10245171
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79678917
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58386804
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.55495243
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51062318
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20148868
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03328983
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79825022
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64372854
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.58531951
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.53139196
13MYB_26560356_Chip-Seq_TH2_Human2.16257611
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06277026
15VDR_22108803_ChIP-Seq_LS180_Human1.90993076
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90857163
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88772068
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82603270
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82017143
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.76106469
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75599745
22VDR_23849224_ChIP-Seq_CD4+_Human1.72935278
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71260744
24HTT_18923047_ChIP-ChIP_STHdh_Human1.69345692
25GATA3_26560356_Chip-Seq_TH2_Human1.68473211
26GATA3_27048872_Chip-Seq_THYMUS_Human1.66203164
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.60924387
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58376782
29ZNF274_21170338_ChIP-Seq_K562_Hela1.55421174
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54987647
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50092343
32TP53_22573176_ChIP-Seq_HFKS_Human1.46940848
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.42810731
34MYB_26560356_Chip-Seq_TH1_Human1.42013438
35RUNX_20019798_ChIP-Seq_JUKART_Human1.39504526
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39246073
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.35966330
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35000778
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32970040
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32184522
41AR_20517297_ChIP-Seq_VCAP_Human1.32121083
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32120406
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.30832926
44TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27325637
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26942885
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.26942885
47TAF2_19829295_ChIP-Seq_ESCs_Human1.25052430
48FOXP3_21729870_ChIP-Seq_TREG_Human1.22732311
49NCOR_22424771_ChIP-Seq_293T_Human1.19278840
50EZH2_22144423_ChIP-Seq_EOC_Human1.18031323
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14945670
52NANOG_20526341_ChIP-Seq_ESCs_Human1.13505029
53ELK1_19687146_ChIP-ChIP_HELA_Human1.12984459
54TAF15_26573619_Chip-Seq_HEK293_Human1.11448229
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10563683
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09562476
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.07965029
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06516718
59ERG_20517297_ChIP-Seq_VCAP_Human1.05111967
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.04494611
61UTX_26944678_Chip-Seq_JUKART_Human1.04302962
62NANOG_19829295_ChIP-Seq_ESCs_Human1.04063174
63SOX2_19829295_ChIP-Seq_ESCs_Human1.04063174
64BCL6_27268052_Chip-Seq_Bcells_Human1.03057298
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02647859
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01652940
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01268863
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01198359
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.00412368
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.00229829
71EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99432872
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98839338
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98432976
74CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98350206
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98255306
76YY1_22570637_ChIP-Seq_MALME-3M_Human0.97876220
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97642510
78ER_23166858_ChIP-Seq_MCF-7_Human0.97449219
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97412593
80CTCF_20526341_ChIP-Seq_ESCs_Human0.95642207
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93771763
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91919616
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91861556
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.91767005
85SPI1_23547873_ChIP-Seq_NB4_Human0.90732120
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90331300
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90112594
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89606222
89P300_27268052_Chip-Seq_Bcells_Human0.89540913
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.89512303
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86300750
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86053185
93MYC_19829295_ChIP-Seq_ESCs_Human0.85913245
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85883744
95MYC_18940864_ChIP-ChIP_HL60_Human0.85762971
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85640281
97MAF_26560356_Chip-Seq_TH2_Human0.85401120
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83957663
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.82336203
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81925558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.27242727
2MP0009785_altered_susceptibility_to3.61611999
3MP0001835_abnormal_antigen_presentation3.53010862
4MP0003763_abnormal_thymus_physiology2.80766694
5MP0009333_abnormal_splenocyte_physiolog2.76536318
6MP0005000_abnormal_immune_tolerance2.53799733
7MP0006082_CNS_inflammation2.49451484
8MP0003866_abnormal_defecation2.46160936
9MP0001800_abnormal_humoral_immune2.31751108
10MP0002166_altered_tumor_susceptibility2.20068495
11MP0002148_abnormal_hypersensitivity_rea2.19967223
12MP0005025_abnormal_response_to2.12781473
13MP0002102_abnormal_ear_morphology2.07556486
14MP0002420_abnormal_adaptive_immunity2.05061483
15MP0002723_abnormal_immune_serum2.04011672
16MP0004147_increased_porphyrin_level2.03751903
17MP0002736_abnormal_nociception_after2.00075573
18MP0001819_abnormal_immune_cell1.98823900
19MP0000372_irregular_coat_pigmentation1.98296958
20MP0005387_immune_system_phenotype1.81227269
21MP0001790_abnormal_immune_system1.81227269
22MP0001968_abnormal_touch/_nociception1.79836451
23MP0001873_stomach_inflammation1.77499971
24MP0005645_abnormal_hypothalamus_physiol1.72110974
25MP0002006_tumorigenesis1.71676775
26MP0002452_abnormal_antigen_presenting1.68493906
27MP0010155_abnormal_intestine_physiology1.63687555
28MP0005377_hearing/vestibular/ear_phenot1.59484108
29MP0003878_abnormal_ear_physiology1.59484108
30MP0002933_joint_inflammation1.58378584
31MP0000716_abnormal_immune_system1.55569499
32MP0003646_muscle_fatigue1.55238130
33MP0001661_extended_life_span1.51886596
34MP0002837_dystrophic_cardiac_calcinosis1.51227632
35MP0000685_abnormal_immune_system1.47354232
36MP0004145_abnormal_muscle_electrophysio1.44683718
37MP0008872_abnormal_physiological_respon1.43002611
38MP0002398_abnormal_bone_marrow1.42765647
39MP0003724_increased_susceptibility_to1.42756949
40MP0001905_abnormal_dopamine_level1.42029402
41MP0001845_abnormal_inflammatory_respons1.41235685
42MP0003011_delayed_dark_adaptation1.40824203
43MP0006072_abnormal_retinal_apoptosis1.37441117
44MP0005075_abnormal_melanosome_morpholog1.35169147
45MP0003806_abnormal_nucleotide_metabolis1.35127944
46MP0002876_abnormal_thyroid_physiology1.31877124
47MP0003786_premature_aging1.29627169
48MP0002277_abnormal_respiratory_mucosa1.29391258
49MP0002405_respiratory_system_inflammati1.27139894
50MP0002638_abnormal_pupillary_reflex1.26016842
51MP0005551_abnormal_eye_electrophysiolog1.24225909
52MP0001919_abnormal_reproductive_system1.21920347
53MP0002138_abnormal_hepatobiliary_system1.21199026
54MP0002722_abnormal_immune_system1.20512439
55MP0005253_abnormal_eye_physiology1.20239750
56MP0005464_abnormal_platelet_physiology1.18420094
57MP0000703_abnormal_thymus_morphology1.18147142
58MP0000689_abnormal_spleen_morphology1.13680010
59MP0002429_abnormal_blood_cell1.13295643
60MP0002419_abnormal_innate_immunity1.10932715
61MP0008469_abnormal_protein_level1.10635195
62MP0002693_abnormal_pancreas_physiology1.09244256
63MP0003436_decreased_susceptibility_to1.08064979
64MP0001984_abnormal_olfaction1.07208975
65MP0003448_altered_tumor_morphology1.06906791
66MP0008875_abnormal_xenobiotic_pharmacok1.06559114
67MP0009764_decreased_sensitivity_to1.02870769
68MP0003045_fibrosis1.02388132
69MP0004885_abnormal_endolymph1.00867539
70MP0005646_abnormal_pituitary_gland0.97334638
71MP0002163_abnormal_gland_morphology0.96770212
72MP0003137_abnormal_impulse_conducting0.96748651
73MP0005389_reproductive_system_phenotype0.95108604
74MP0009763_increased_sensitivity_to0.94578036
75MP0005410_abnormal_fertilization0.88539610
76MP0009745_abnormal_behavioral_response0.88514354
77MP0002095_abnormal_skin_pigmentation0.87629814
78MP0001542_abnormal_bone_strength0.85782685
79MP0001853_heart_inflammation0.85198360
80MP0005636_abnormal_mineral_homeostasis0.84880863
81MP0002822_catalepsy0.84237254
82MP0009643_abnormal_urine_homeostasis0.82982069
83MP0001764_abnormal_homeostasis0.80807664
84MP0006036_abnormal_mitochondrial_physio0.80702488
85MP0010386_abnormal_urinary_bladder0.79217152
86MP0005360_urolithiasis0.78567995
87MP0004947_skin_inflammation0.76161177
88MP0003880_abnormal_central_pattern0.74895317
89MP0001533_abnormal_skeleton_physiology0.73854050
90MP0004043_abnormal_pH_regulation0.73638050
91MP0003195_calcinosis0.72639120
92MP0002733_abnormal_thermal_nociception0.72422204
93MP0005379_endocrine/exocrine_gland_phen0.71590337
94MP0002909_abnormal_adrenal_gland0.71098744
95MP0001485_abnormal_pinna_reflex0.71026235
96MP0001765_abnormal_ion_homeostasis0.70331613
97MP0008995_early_reproductive_senescence0.69961993
98MP0001986_abnormal_taste_sensitivity0.69089573
99MP0001529_abnormal_vocalization0.69044412
100MP0005332_abnormal_amino_acid0.67931658

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.78242071
2T lymphocytopenia (HP:0005403)5.09707354
3Abnormality of T cell number (HP:0011839)4.88586054
4Hypoproteinemia (HP:0003075)4.38282888
5Autoimmune hemolytic anemia (HP:0001890)4.35372850
6Elevated erythrocyte sedimentation rate (HP:0003565)4.28541125
7IgG deficiency (HP:0004315)4.19376138
8Mitochondrial inheritance (HP:0001427)4.11265476
9Severe combined immunodeficiency (HP:0004430)4.00816481
10Acute necrotizing encephalopathy (HP:0006965)3.88751808
11Abnormal mitochondria in muscle tissue (HP:0008316)3.84102513
12Increased intramyocellular lipid droplets (HP:0012240)3.74602695
13Abnormality of T cells (HP:0002843)3.72844960
14Thyroiditis (HP:0100646)3.42074988
15Hepatocellular necrosis (HP:0001404)3.37191743
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34515709
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34515709
18Renal Fanconi syndrome (HP:0001994)3.32379453
19Increased CSF lactate (HP:0002490)3.31076175
20Increased hepatocellular lipid droplets (HP:0006565)3.25243471
21Progressive macrocephaly (HP:0004481)3.24290629
22Chronic diarrhea (HP:0002028)3.19279776
23Hepatic necrosis (HP:0002605)3.10892865
24Increased IgM level (HP:0003496)3.09843918
25Congenital stationary night blindness (HP:0007642)3.08054242
263-Methylglutaconic aciduria (HP:0003535)3.05109670
27Combined immunodeficiency (HP:0005387)3.03855883
28Acute encephalopathy (HP:0006846)3.03499490
29Increased muscle lipid content (HP:0009058)3.03170804
30Abnormality of the prostate (HP:0008775)2.95965941
31Abnormality of eosinophils (HP:0001879)2.90464857
32Stomatitis (HP:0010280)2.86652826
33Lipid accumulation in hepatocytes (HP:0006561)2.82652214
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.72760895
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66416545
36Autoimmune thrombocytopenia (HP:0001973)2.65011659
37Generalized aminoaciduria (HP:0002909)2.64957100
38Pancreatic cysts (HP:0001737)2.56316692
39Cerebral edema (HP:0002181)2.55765928
40Abolished electroretinogram (ERG) (HP:0000550)2.55500040
41IgM deficiency (HP:0002850)2.52323496
42Abnormality of B cell number (HP:0010975)2.48279888
43Abnormal rod and cone electroretinograms (HP:0008323)2.43604908
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42286301
45Recurrent bronchitis (HP:0002837)2.40990053
46Exertional dyspnea (HP:0002875)2.39129278
47Lymphopenia (HP:0001888)2.36681262
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36141899
49Amyotrophic lateral sclerosis (HP:0007354)2.35013319
50Eosinophilia (HP:0001880)2.34877906
51Optic disc pallor (HP:0000543)2.29999988
52Constricted visual fields (HP:0001133)2.29966834
53Attenuation of retinal blood vessels (HP:0007843)2.29035534
54Increased serum lactate (HP:0002151)2.28452211
55Abnormality of T cell physiology (HP:0011840)2.27968351
56Renal cortical cysts (HP:0000803)2.27276200
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27125150
58Chronic mucocutaneous candidiasis (HP:0002728)2.25766174
59Recurrent cutaneous fungal infections (HP:0011370)2.25766174
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.21189219
61Lactic acidosis (HP:0003128)2.19280126
62Encephalitis (HP:0002383)2.17155120
63Abnormal albumin level (HP:0012116)2.15965566
64Hypoalbuminemia (HP:0003073)2.15965566
65B lymphocytopenia (HP:0010976)2.15185146
66Leukocytosis (HP:0001974)2.12025733
67Pancytopenia (HP:0001876)2.08823180
68Hemoptysis (HP:0002105)2.05987653
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05759686
70Abnormality of alanine metabolism (HP:0010916)2.05759686
71Hyperalaninemia (HP:0003348)2.05759686
72Panhypogammaglobulinemia (HP:0003139)2.05247585
73Meningitis (HP:0001287)2.03816692
74Abnormality of renal resorption (HP:0011038)2.01717887
75Abnormality of macrophages (HP:0004311)2.01093124
76Pustule (HP:0200039)2.00988834
77Gangrene (HP:0100758)1.98397401
78Molar tooth sign on MRI (HP:0002419)1.98375608
79Abnormality of midbrain morphology (HP:0002418)1.98375608
80Aplasia/hypoplasia of the uterus (HP:0008684)1.96782753
81Pancreatic fibrosis (HP:0100732)1.96246458
82Exercise intolerance (HP:0003546)1.94710510
83Hemiplegia (HP:0002301)1.94048819
84Decreased central vision (HP:0007663)1.94017975
85True hermaphroditism (HP:0010459)1.92241508
86Abnormality of the renal cortex (HP:0011035)1.91770272
87Vasculitis (HP:0002633)1.91251470
88Recurrent fungal infections (HP:0002841)1.91104610
89Oral leukoplakia (HP:0002745)1.89297866
90Joint swelling (HP:0001386)1.87671022
91Granulocytopenia (HP:0001913)1.86688906
92Respiratory failure (HP:0002878)1.86484077
93Abnormality of urine glucose concentration (HP:0011016)1.86281782
94Glycosuria (HP:0003076)1.86281782
95Chronic obstructive pulmonary disease (HP:0006510)1.86128351
96Obstructive lung disease (HP:0006536)1.86128351
97Hypoplasia of the thymus (HP:0000778)1.85917041
98Pulmonary infiltrates (HP:0002113)1.85803648
99Lymphoma (HP:0002665)1.85327160
100Bronchitis (HP:0012387)1.84628967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.94033864
2KDR5.87918906
3TESK24.33775266
4MAP3K122.82136710
5BCKDK2.74483399
6MAP4K22.69173822
7MAP4K12.47281511
8ADRBK22.33091528
9TLK12.22773891
10ITK2.17232529
11TESK12.16510311
12VRK22.15541261
13LIMK12.10616024
14ZAK2.09982028
15MST41.99684574
16EIF2AK31.93162932
17BUB11.87857646
18MYLK1.71620289
19TAOK31.64581104
20FES1.55750586
21GRK11.54171410
22FRK1.53278349
23SYK1.45164475
24CSK1.40546890
25VRK11.34918116
26SCYL21.29032087
27GRK71.21417134
28PRKCQ1.20618074
29DAPK11.10897298
30LCK1.10424444
31NUAK11.05883055
32PIK3CA0.98954854
33TEC0.96997662
34MAPKAPK30.96608411
35STK160.95609647
36PINK10.94042261
37ZAP700.93887881
38MUSK0.91379845
39BTK0.85687433
40MAP2K60.85557911
41JAK30.85220774
42LYN0.84887207
43WNK40.83759844
44GRK60.78213868
45ROCK10.72694488
46CSNK1G30.71875130
47INSRR0.71090636
48EIF2AK10.71000777
49IKBKB0.64931292
50BMPR1B0.64424454
51TIE10.64097965
52OBSCN0.63555985
53KIT0.61343865
54ADRBK10.59423395
55CSF1R0.58665458
56TNK20.57672362
57NME10.55650448
58PASK0.54529620
59FYN0.54001490
60OXSR10.51851680
61CSNK1G10.50427502
62IGF1R0.49984117
63CAMK2A0.49352623
64PRKCA0.49063318
65MAP3K110.48779585
66ERBB30.48565597
67RPS6KA50.48253884
68NEK10.46706978
69BMPR20.46658291
70WNK30.46406291
71RPS6KA40.45946073
72DAPK30.44970633
73CSNK1A1L0.44569836
74TRIM280.44539651
75CSNK1G20.43085959
76PLK20.42815386
77AURKA0.42757942
78INSR0.41844757
79CSNK1A10.41689663
80ILK0.40346291
81TBK10.40210151
82PIM20.39059510
83PRKACA0.36985294
84IKBKE0.35269386
85PIM10.33827325
86DAPK20.31606263
87CAMK2D0.31468956
88PRKCE0.30940959
89GRK50.29289435
90PAK10.28149664
91CDK190.27379538
92CAMKK20.25424011
93ABL10.24371244
94CSNK2A10.24119398
95HCK0.22802537
96CAMK2G0.22599552
97PHKG10.21665641
98PHKG20.21665641
99STK390.20739143
100PDK20.20037486

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.03372508
2Proteasome_Homo sapiens_hsa030504.62871831
3Oxidative phosphorylation_Homo sapiens_hsa001903.57718816
4Graft-versus-host disease_Homo sapiens_hsa053323.39979900
5Autoimmune thyroid disease_Homo sapiens_hsa053203.14459968
6Antigen processing and presentation_Homo sapiens_hsa046122.95585046
7Allograft rejection_Homo sapiens_hsa053302.93696173
8Parkinsons disease_Homo sapiens_hsa050122.90969088
9Type I diabetes mellitus_Homo sapiens_hsa049402.48601212
10Hematopoietic cell lineage_Homo sapiens_hsa046402.35881552
11Protein export_Homo sapiens_hsa030602.30388764
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27165003
13Rheumatoid arthritis_Homo sapiens_hsa053232.06569197
14Alzheimers disease_Homo sapiens_hsa050102.01428683
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96599561
16T cell receptor signaling pathway_Homo sapiens_hsa046601.87848637
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82136428
18Asthma_Homo sapiens_hsa053101.70897021
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.70523286
20Huntingtons disease_Homo sapiens_hsa050161.69623074
21Cardiac muscle contraction_Homo sapiens_hsa042601.62475861
22RNA polymerase_Homo sapiens_hsa030201.52598009
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37461494
24Phototransduction_Homo sapiens_hsa047441.36636816
25Salmonella infection_Homo sapiens_hsa051321.26994441
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23962620
27Viral myocarditis_Homo sapiens_hsa054161.18666438
28Collecting duct acid secretion_Homo sapiens_hsa049661.18631174
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18395784
30Nitrogen metabolism_Homo sapiens_hsa009101.16565061
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12927219
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.03626749
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00015832
34Ribosome_Homo sapiens_hsa030100.98084668
35Measles_Homo sapiens_hsa051620.97849529
36Shigellosis_Homo sapiens_hsa051310.94421205
37Peroxisome_Homo sapiens_hsa041460.92113041
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89776189
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86308578
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85511642
41Sulfur metabolism_Homo sapiens_hsa009200.85063756
42Butanoate metabolism_Homo sapiens_hsa006500.84224771
43Systemic lupus erythematosus_Homo sapiens_hsa053220.82012659
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81906689
45Linoleic acid metabolism_Homo sapiens_hsa005910.79533534
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.77430589
47Retinol metabolism_Homo sapiens_hsa008300.73672382
48Caffeine metabolism_Homo sapiens_hsa002320.73608248
49Malaria_Homo sapiens_hsa051440.73245237
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70714607
51Regulation of autophagy_Homo sapiens_hsa041400.69139007
52Staphylococcus aureus infection_Homo sapiens_hsa051500.66705922
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.65827408
54Basal transcription factors_Homo sapiens_hsa030220.59572035
55One carbon pool by folate_Homo sapiens_hsa006700.58091680
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57982190
57Olfactory transduction_Homo sapiens_hsa047400.57960884
58Chemical carcinogenesis_Homo sapiens_hsa052040.57644098
59RNA degradation_Homo sapiens_hsa030180.49583051
60Tryptophan metabolism_Homo sapiens_hsa003800.48758742
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.47208085
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47134506
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46271179
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44381228
65Morphine addiction_Homo sapiens_hsa050320.44368960
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43243018
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42769245
68Purine metabolism_Homo sapiens_hsa002300.41807525
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41363456
70Pyrimidine metabolism_Homo sapiens_hsa002400.41102951
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40083331
72Herpes simplex infection_Homo sapiens_hsa051680.39932482
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39925563
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38593315
75GABAergic synapse_Homo sapiens_hsa047270.38343112
76Chemokine signaling pathway_Homo sapiens_hsa040620.37071390
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36418390
78Homologous recombination_Homo sapiens_hsa034400.35457493
79Nicotine addiction_Homo sapiens_hsa050330.34695019
80Ether lipid metabolism_Homo sapiens_hsa005650.34568164
81Metabolic pathways_Homo sapiens_hsa011000.33101474
82Nucleotide excision repair_Homo sapiens_hsa034200.33048457
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32687330
84Arachidonic acid metabolism_Homo sapiens_hsa005900.29899524
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29548663
86Fatty acid elongation_Homo sapiens_hsa000620.28702135
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28612894
88Mineral absorption_Homo sapiens_hsa049780.28466441
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27011201
90Mismatch repair_Homo sapiens_hsa034300.26171013
91Selenocompound metabolism_Homo sapiens_hsa004500.23911050
92Phagosome_Homo sapiens_hsa041450.23200560
93Taste transduction_Homo sapiens_hsa047420.21424432
94Pertussis_Homo sapiens_hsa051330.20652190
95Epstein-Barr virus infection_Homo sapiens_hsa051690.20199927
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18346668
97Legionellosis_Homo sapiens_hsa051340.18040836
98Tyrosine metabolism_Homo sapiens_hsa003500.17722167
99Alcoholism_Homo sapiens_hsa050340.16369493
100Serotonergic synapse_Homo sapiens_hsa047260.15988264

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