MYL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.58070193
2muscle filament sliding (GO:0030049)6.15681351
3actin-myosin filament sliding (GO:0033275)6.15681351
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.07850241
5actin-mediated cell contraction (GO:0070252)5.52981930
6sarcomere organization (GO:0045214)5.50524608
7myofibril assembly (GO:0030239)5.13347923
8cardiac muscle cell development (GO:0055013)4.91588925
9negative regulation of striated muscle cell apoptotic process (GO:0010664)4.85377167
10actomyosin structure organization (GO:0031032)4.71621934
11cardiac cell development (GO:0055006)4.70197403
12chondrocyte proliferation (GO:0035988)4.58748359
13cardiac muscle tissue morphogenesis (GO:0055008)4.46266986
14protein heterotrimerization (GO:0070208)4.42592701
15sequestering of extracellular ligand from receptor (GO:0035581)4.36350239
16atrioventricular valve morphogenesis (GO:0003181)4.34578355
17actin filament-based movement (GO:0030048)4.32330706
18regulation of cardioblast differentiation (GO:0051890)4.31021895
19actin filament depolymerization (GO:0030042)4.29129924
20muscle tissue morphogenesis (GO:0060415)4.28252059
21ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.27283206
22collagen fibril organization (GO:0030199)4.22917827
23atrial septum morphogenesis (GO:0060413)4.11045239
24heart trabecula formation (GO:0060347)4.09964399
25endocardial cushion development (GO:0003197)4.03765795
26cardiac muscle contraction (GO:0060048)4.02241375
27ventricular cardiac muscle cell development (GO:0055015)4.01683378
28epithelial cell-cell adhesion (GO:0090136)4.00141688
29outflow tract septum morphogenesis (GO:0003148)3.88193550
30cell migration involved in heart development (GO:0060973)3.87515382
31barbed-end actin filament capping (GO:0051016)3.84581077
32regulation of skeletal muscle contraction (GO:0014819)3.79717152
33type B pancreatic cell proliferation (GO:0044342)3.79110923
34virion attachment to host cell (GO:0019062)3.75669475
35adhesion of symbiont to host cell (GO:0044650)3.75669475
36positive regulation of endothelial cell apoptotic process (GO:2000353)3.74354334
37trabecula formation (GO:0060343)3.74114161
38relaxation of smooth muscle (GO:0044557)3.68924502
39negative regulation of smooth muscle cell migration (GO:0014912)3.65696711
40wound healing, spreading of epidermal cells (GO:0035313)3.62019225
41vascular endothelial growth factor signaling pathway (GO:0038084)3.61165127
42negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.60524199
43bone trabecula formation (GO:0060346)3.58770135
44cardiac right ventricle morphogenesis (GO:0003215)3.53903703
45regulation of striated muscle cell apoptotic process (GO:0010662)3.52065218
46cell proliferation involved in metanephros development (GO:0072203)3.51695955
47endodermal cell differentiation (GO:0035987)3.51361055
48adherens junction assembly (GO:0034333)3.51134576
49skin morphogenesis (GO:0043589)3.50698589
50cGMP-mediated signaling (GO:0019934)3.48928824
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.47481525
52extracellular matrix assembly (GO:0085029)3.47117831
53regulation of integrin-mediated signaling pathway (GO:2001044)3.46237957
54cardiac muscle hypertrophy (GO:0003300)3.45617633
55cell adhesion mediated by integrin (GO:0033627)3.45046709
56plasma membrane repair (GO:0001778)3.43190733
57focal adhesion assembly (GO:0048041)3.42480665
58cell-substrate adherens junction assembly (GO:0007045)3.42480665
59regulation of cardiac muscle cell apoptotic process (GO:0010665)3.41819176
60regulation of tight junction assembly (GO:2000810)3.40803496
61basement membrane organization (GO:0071711)3.40376001
62negative regulation of potassium ion transmembrane transport (GO:1901380)3.31342598
63mesenchyme morphogenesis (GO:0072132)3.28875291
64endocardial cushion morphogenesis (GO:0003203)3.28563948
65adhesion of symbiont to host (GO:0044406)3.26525539
66cellular response to vitamin (GO:0071295)3.25670696
67striated muscle hypertrophy (GO:0014897)3.25566601
68glomerular filtration (GO:0003094)3.25044215
69positive regulation of epithelial to mesenchymal transition (GO:0010718)3.23977961
70positive regulation of receptor recycling (GO:0001921)3.18193887
71heart contraction (GO:0060047)3.16900611
72heart process (GO:0003015)3.16900611
73positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.16328632
74regulation of the force of heart contraction (GO:0002026)3.14565057
75cardiac epithelial to mesenchymal transition (GO:0060317)3.14189001
76metanephric mesenchyme development (GO:0072075)3.12969255
77endothelial cell morphogenesis (GO:0001886)3.12509979
78renal filtration (GO:0097205)3.10602869
79extracellular fibril organization (GO:0043206)3.09475019
80wound healing, spreading of cells (GO:0044319)3.07867750
81glomerular basement membrane development (GO:0032836)3.07143269
82planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05852060
83fibroblast migration (GO:0010761)3.05420644
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.03632534
85retina vasculature morphogenesis in camera-type eye (GO:0061299)3.02291542
86multicellular organismal metabolic process (GO:0044236)3.01017552
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00998017
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99953587
89vascular smooth muscle contraction (GO:0014829)2.99340102
90hypotonic response (GO:0006971)2.99093811
91cell proliferation involved in kidney development (GO:0072111)2.98795779
92kidney mesenchyme development (GO:0072074)2.98490892
93multicellular organismal catabolic process (GO:0044243)2.97021515
94extracellular matrix disassembly (GO:0022617)2.97001668
95positive regulation of blood vessel endothelial cell migration (GO:0043536)2.95949269
96cardiac muscle cell proliferation (GO:0060038)2.94534012
97keratan sulfate catabolic process (GO:0042340)2.93501409
98axon extension involved in axon guidance (GO:0048846)2.91634469
99neuron projection extension involved in neuron projection guidance (GO:1902284)2.91634469
100positive regulation of cardiac muscle tissue development (GO:0055025)2.90755084
101apoptotic cell clearance (GO:0043277)2.90081926
102muscle hypertrophy (GO:0014896)2.89929456
103regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.89657401
104heart valve morphogenesis (GO:0003179)2.89339581
105positive regulation of cardiac muscle cell proliferation (GO:0060045)2.88690073
106positive regulation of stem cell differentiation (GO:2000738)2.88650244
107adult heart development (GO:0007512)2.88455112
108stress fiber assembly (GO:0043149)2.88262873
109collagen metabolic process (GO:0032963)2.88161294
110venous blood vessel morphogenesis (GO:0048845)2.85470962
111protein localization to cell surface (GO:0034394)2.85126089
112regulation of transforming growth factor beta2 production (GO:0032909)2.82313461
113fibril organization (GO:0097435)2.81578285
114regulation of smooth muscle cell differentiation (GO:0051150)2.81222220
115negative regulation of fatty acid transport (GO:2000192)2.80883992
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80546599
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80355083
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.78350407
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.76640524
120collagen catabolic process (GO:0030574)2.76543768
121extracellular matrix organization (GO:0030198)2.76509306
122tooth mineralization (GO:0034505)2.76156106
123striated muscle contraction (GO:0006941)2.75634413
124extracellular structure organization (GO:0043062)2.75473681
125cardiac septum morphogenesis (GO:0060411)2.72048431
126substrate-dependent cell migration (GO:0006929)2.71866121
127multicellular organismal macromolecule metabolic process (GO:0044259)2.71309388
128substrate adhesion-dependent cell spreading (GO:0034446)2.71155379
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69994368
130muscle cell migration (GO:0014812)2.69093234
131positive regulation of cardiac muscle tissue growth (GO:0055023)2.68671936
132cell-substrate junction assembly (GO:0007044)2.67528138
133mesenchymal-epithelial cell signaling (GO:0060638)2.65916760
134negative regulation of chondrocyte differentiation (GO:0032331)2.65817204
135positive regulation of osteoblast proliferation (GO:0033690)2.65383175
136paraxial mesoderm development (GO:0048339)2.64552046
137negative regulation of protein localization to cell surface (GO:2000009)2.60748611
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60204355
139cell migration involved in sprouting angiogenesis (GO:0002042)2.59463776
140smooth muscle tissue development (GO:0048745)2.57983940
141dermatan sulfate biosynthetic process (GO:0030208)2.53154540
142dermatan sulfate metabolic process (GO:0030205)2.52828974
143blood vessel maturation (GO:0001955)2.51994285
144protein targeting to plasma membrane (GO:0072661)2.50313431
145cellular response to epinephrine stimulus (GO:0071872)2.48665135
146negative regulation of homotypic cell-cell adhesion (GO:0034111)2.46287446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.12123607
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.94189516
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.69619793
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.14753294
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.85565637
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.35271520
7* CLOCK_20551151_ChIP-Seq_293T_Human3.27850295
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26194487
9* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.78288600
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.77167209
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.64755667
12MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.64479429
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51700444
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.46877223
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.38984387
16CJUN_26792858_Chip-Seq_BT549_Human2.35861712
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.18647702
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.18647702
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14150207
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13388096
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10481911
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03615524
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.91533464
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.91161792
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87196894
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.86275781
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82315694
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81077993
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.80717036
30BRD4_25478319_ChIP-Seq_HGPS_Human1.79907496
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76082966
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73258861
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73021592
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72158191
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.71412307
36NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.69961052
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68254406
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68254406
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68137995
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63396518
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55392348
42SOX2_20726797_ChIP-Seq_SW620_Human1.54280187
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53030286
44GATA4_21415370_ChIP-Seq_HL-1_Mouse1.51490016
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49362744
46LXR_22292898_ChIP-Seq_THP-1_Human1.48557606
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46933903
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43186662
49TP53_22127205_ChIP-Seq_IMR90_Human1.38646358
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36165395
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36165395
52RACK7_27058665_Chip-Seq_MCF-7_Human1.34424541
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.34124769
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33966051
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.31950135
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.30470718
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28731617
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28385038
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27714304
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27602379
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.26862326
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25385875
63ATF3_27146783_Chip-Seq_COLON_Human1.24925600
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23543965
65KDM2B_26808549_Chip-Seq_K562_Human1.23489580
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23418972
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22356847
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21701392
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21318832
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19384659
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18566150
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17773516
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.17420125
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15218386
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.14434034
76TP53_23651856_ChIP-Seq_MEFs_Mouse1.14378951
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13338504
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11844809
79TP53_18474530_ChIP-ChIP_U2OS_Human1.11831424
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11098887
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10265560
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10164358
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10164358
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09781601
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08148873
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05194452
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05003493
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04733341
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04549342
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02349317
91TP53_16413492_ChIP-PET_HCT116_Human1.01971458
92* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01735497
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00431044
94RNF2_27304074_Chip-Seq_ESCs_Mouse0.99984752
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99869432
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99830806
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98528635
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98508036
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98495897
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.98356123
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.97797680
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97657113
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97304995
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97206192
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96817929
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.95912239
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95493134
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94370268
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94141503
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93568050
111KDM2B_26808549_Chip-Seq_DND41_Human0.92874735
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92068933
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91794736
114* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91130876
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90301000
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89050264
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88859131
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87752934
119NFI_21473784_ChIP-Seq_ESCs_Mouse0.86838032
120SA1_22415368_ChIP-Seq_MEFs_Mouse0.85942096
121EOMES_21245162_ChIP-Seq_HESCs_Human0.83793225
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83179213
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.82258246
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81299261
125CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80939985
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80793579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.27189696
2MP0004084_abnormal_cardiac_muscle3.94893621
3MP0003279_aneurysm3.81808783
4MP0004272_abnormal_basement_membrane3.28158976
5MP0005275_abnormal_skin_tensile3.13888539
6MP0005503_abnormal_tendon_morphology3.06096280
7MP0009384_cardiac_valve_regurgitation2.93490766
8MP0004036_abnormal_muscle_relaxation2.82587938
9MP0003705_abnormal_hypodermis_morpholog2.75137976
10MP0006054_spinal_hemorrhage2.60480277
11MP0003566_abnormal_cell_adhesion2.58826075
12MP0005330_cardiomyopathy2.57662543
13MP0000749_muscle_degeneration2.56214965
14MP0005623_abnormal_meninges_morphology2.38228166
15MP0002837_dystrophic_cardiac_calcinosis2.31757474
16MP0001958_emphysema2.30205961
17MP0000751_myopathy2.29805924
18MP0002972_abnormal_cardiac_muscle2.23099975
19MP0005620_abnormal_muscle_contractility2.16277114
20MP0008775_abnormal_heart_ventricle2.15947011
21MP0006138_congestive_heart_failure2.03702854
22MP0000013_abnormal_adipose_tissue1.94622566
23MP0004087_abnormal_muscle_fiber1.90806296
24MP0003950_abnormal_plasma_membrane1.83911741
25MP0004215_abnormal_myocardial_fiber1.83800447
26MP0000767_abnormal_smooth_muscle1.83215591
27MP0010630_abnormal_cardiac_muscle1.79988318
28MP0000750_abnormal_muscle_regeneration1.74267799
29MP0003385_abnormal_body_wall1.69204959
30MP0005385_cardiovascular_system_phenoty1.69189290
31MP0001544_abnormal_cardiovascular_syste1.69189290
32MP0005023_abnormal_wound_healing1.66086048
33MP0003941_abnormal_skin_development1.63463325
34MP0002295_abnormal_pulmonary_circulatio1.59331269
35MP0003828_pulmonary_edema1.59101510
36MP0003091_abnormal_cell_migration1.49548003
37MP0005367_renal/urinary_system_phenotyp1.48633827
38MP0000516_abnormal_urinary_system1.48633827
39MP0010368_abnormal_lymphatic_system1.47647001
40MP0010030_abnormal_orbit_morphology1.47107871
41MP0002127_abnormal_cardiovascular_syste1.43590007
42MP0005508_abnormal_skeleton_morphology1.40844144
43MP0005257_abnormal_intraocular_pressure1.37797993
44MP0001542_abnormal_bone_strength1.36435338
45MP0003137_abnormal_impulse_conducting1.32330107
46MP0004085_abnormal_heartbeat1.30235939
47MP0005595_abnormal_vascular_smooth1.27017396
48MP0001879_abnormal_lymphatic_vessel1.25782558
49MP0010352_gastrointestinal_tract_polyps1.25691465
50MP0002254_reproductive_system_inflammat1.25361382
51MP0009250_abnormal_appendicular_skeleto1.24651418
52MP0009780_abnormal_chondrocyte_physiolo1.24022260
53MP0000534_abnormal_ureter_morphology1.21780253
54MP0002128_abnormal_blood_circulation1.20356652
55MP0003122_maternal_imprinting1.18317042
56MP0003942_abnormal_urinary_system1.17548203
57MP0004484_altered_response_of1.17514346
58MP0004145_abnormal_muscle_electrophysio1.15095955
59MP0002269_muscular_atrophy1.14234890
60MP0010386_abnormal_urinary_bladder1.09289559
61MP0004858_abnormal_nervous_system1.09214562
62MP0002106_abnormal_muscle_physiology1.08761722
63MP0002282_abnormal_trachea_morphology1.07254740
64MP0003567_abnormal_fetal_cardiomyocyte1.06576191
65MP0000537_abnormal_urethra_morphology1.05633974
66MP0000230_abnormal_systemic_arterial1.05124982
67MP0001614_abnormal_blood_vessel1.05011091
68MP0000266_abnormal_heart_morphology1.04846895
69MP0000759_abnormal_skeletal_muscle1.03634056
70MP0005369_muscle_phenotype1.03277742
71MP0000733_abnormal_muscle_development1.03215503
72MP0002925_abnormal_cardiovascular_devel1.01538926
73MP0009053_abnormal_anal_canal1.01044613
74MP0005164_abnormal_response_to1.00533514
75MP0003115_abnormal_respiratory_system0.99794099
76MP0001849_ear_inflammation0.98188629
77MP0002060_abnormal_skin_morphology0.97245198
78MP0003283_abnormal_digestive_organ0.97044855
79MP0002108_abnormal_muscle_morphology0.96549083
80MP0000747_muscle_weakness0.96374716
81MP0004233_abnormal_muscle_weight0.95983179
82MP0000003_abnormal_adipose_tissue0.95920548
83MP0002877_abnormal_melanocyte_morpholog0.95585244
84MP0003221_abnormal_cardiomyocyte_apopto0.92200136
85MP0001348_abnormal_lacrimal_gland0.90737075
86MP0008004_abnormal_stomach_pH0.88444566
87MP0002896_abnormal_bone_mineralization0.85281604
88MP0005165_increased_susceptibility_to0.85279385
89MP0000343_altered_response_to0.84541291
90MP0002933_joint_inflammation0.84316305
91MP0003045_fibrosis0.82279212
92MP0000163_abnormal_cartilage_morphology0.80688511
93MP0004130_abnormal_muscle_cell0.80377838
94MP0001661_extended_life_span0.75631208
95MP0005388_respiratory_system_phenotype0.75350614
96MP0002133_abnormal_respiratory_system0.75350614
97MP0001243_abnormal_dermal_layer0.74957890
98MP0001299_abnormal_eye_distance/0.74372814
99MP0003123_paternal_imprinting0.73824744
100MP0000462_abnormal_digestive_system0.73565653
101MP0002998_abnormal_bone_remodeling0.73467729
102MP0004134_abnormal_chest_morphology0.72375291
103MP0000428_abnormal_craniofacial_morphol0.71944242
104MP0004510_myositis0.71270634
105MP0002115_abnormal_skeleton_extremities0.71136724
106MP0003935_abnormal_craniofacial_develop0.70263418
107MP0004883_abnormal_blood_vessel0.69865681
108MP0005409_darkened_coat_color0.69545744
109MP0005375_adipose_tissue_phenotype0.69340641
110MP0001175_abnormal_lung_morphology0.68925902
111MP0003448_altered_tumor_morphology0.68251781
112MP0005666_abnormal_adipose_tissue0.67691415
113MP0000049_abnormal_middle_ear0.67033447
114MP0002113_abnormal_skeleton_development0.66777214
115MP0005670_abnormal_white_adipose0.66243432
116MP0000249_abnormal_blood_vessel0.66238100
117MP0000762_abnormal_tongue_morphology0.66145903
118MP0005390_skeleton_phenotype0.65988880
119MP0002932_abnormal_joint_morphology0.65873411

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)7.13688224
2Aortic dissection (HP:0002647)6.74736152
3Protrusio acetabuli (HP:0003179)6.39200208
4Premature rupture of membranes (HP:0001788)6.12358273
5Type 1 muscle fiber predominance (HP:0003803)4.68015232
6Cerebral aneurysm (HP:0004944)4.64040504
7Sudden death (HP:0001699)4.24788832
8Ankle contracture (HP:0006466)3.99033203
9Right ventricular cardiomyopathy (HP:0011663)3.92192002
10Abnormality of dentin (HP:0010299)3.71693693
11Ventricular tachycardia (HP:0004756)3.65900145
12Lipoatrophy (HP:0100578)3.61139753
13Dilatation of the ascending aorta (HP:0005111)3.47698988
14Atrophic scars (HP:0001075)3.35043523
15Soft skin (HP:0000977)3.30424603
16Atrial fibrillation (HP:0005110)3.26032340
17Peritonitis (HP:0002586)3.25741118
18Aneurysm (HP:0002617)3.20968610
19Spinal rigidity (HP:0003306)3.19061755
20Hyporeflexia of lower limbs (HP:0002600)3.13347393
21Broad metatarsal (HP:0001783)3.12118148
22Slender build (HP:0001533)3.09336145
23Abnormality of the left ventricular outflow tract (HP:0011103)3.05120189
24Subaortic stenosis (HP:0001682)3.05120189
25Exercise-induced muscle cramps (HP:0003710)3.04440215
26Abnormality of the calf musculature (HP:0001430)3.01742528
27Primary atrial arrhythmia (HP:0001692)3.01734419
28Shallow orbits (HP:0000586)3.00459257
29Increased connective tissue (HP:0009025)3.00109301
30Supraventricular arrhythmia (HP:0005115)2.96840979
31Bladder diverticulum (HP:0000015)2.93140889
32Supraventricular tachycardia (HP:0004755)2.89212692
33Scapular winging (HP:0003691)2.88378244
34Fragile skin (HP:0001030)2.87888442
35Increased density of long bones (HP:0006392)2.84427274
36Wormian bones (HP:0002645)2.82967760
37Muscle fiber splitting (HP:0003555)2.79008059
38Facial diplegia (HP:0001349)2.76681775
39Mildly elevated creatine phosphokinase (HP:0008180)2.76356702
40Gastrointestinal dysmotility (HP:0002579)2.70207717
41Aortic regurgitation (HP:0001659)2.69217302
42Blue sclerae (HP:0000592)2.66253201
43Spondylolisthesis (HP:0003302)2.64421306
44Vascular tortuosity (HP:0004948)2.64239040
45Joint laxity (HP:0001388)2.58956471
46Biconcave vertebral bodies (HP:0004586)2.58689195
47Bicuspid aortic valve (HP:0001647)2.56866488
48Mitral valve prolapse (HP:0001634)2.54868761
49Ventricular arrhythmia (HP:0004308)2.51935552
50Mesomelia (HP:0003027)2.51732741
51Hypoventilation (HP:0002791)2.51158691
52Dilated cardiomyopathy (HP:0001644)2.48945307
53Increased variability in muscle fiber diameter (HP:0003557)2.47100617
54Neonatal short-limb short stature (HP:0008921)2.46360819
55Short hallux (HP:0010109)2.46232069
56Prolonged QT interval (HP:0001657)2.41710273
57Calf muscle hypertrophy (HP:0008981)2.40451785
58EMG: myopathic abnormalities (HP:0003458)2.38657653
59Ectopia lentis (HP:0001083)2.37167476
60Wrist flexion contracture (HP:0001239)2.37127399
61Pulmonary artery stenosis (HP:0004415)2.36147521
62Vertebral compression fractures (HP:0002953)2.35739361
63Round ear (HP:0100830)2.30227163
64Exercise-induced myalgia (HP:0003738)2.29667417
65Aplasia/Hypoplasia of the hallux (HP:0008362)2.29341509
66Arterial tortuosity (HP:0005116)2.26222295
67Cervical subluxation (HP:0003308)2.20113316
68Abnormality of skeletal muscle fiber size (HP:0012084)2.19192703
69Overgrowth (HP:0001548)2.18040350
70Joint stiffness (HP:0001387)2.17457125
71Neck muscle weakness (HP:0000467)2.16764818
72Follicular hyperkeratosis (HP:0007502)2.15991573
73Aortic valve stenosis (HP:0001650)2.14956453
74Abnormality of the calcaneus (HP:0008364)2.14003924
75Elbow flexion contracture (HP:0002987)2.14002728
76Asymmetric septal hypertrophy (HP:0001670)2.13958393
77Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.13226577
78Wide anterior fontanel (HP:0000260)2.09850610
79Distal lower limb amyotrophy (HP:0008944)2.08011895
80Increased mean platelet volume (HP:0011877)2.07270076
81Bradycardia (HP:0001662)2.06949111
82Abnormality of the acetabulum (HP:0003170)2.06254815
83Disproportionate tall stature (HP:0001519)2.05233085
84Generalized amyotrophy (HP:0003700)2.02477676
85Palpitations (HP:0001962)2.01129101
86Long toe (HP:0010511)2.00098402
87Muscle hypertrophy of the lower extremities (HP:0008968)1.99704775
88Syncope (HP:0001279)1.98561820
89Nemaline bodies (HP:0003798)1.98215617
90Coronal craniosynostosis (HP:0004440)1.97923264
91Hip contracture (HP:0003273)1.97231045
92Centrally nucleated skeletal muscle fibers (HP:0003687)1.95645933
93Hyperextensible skin (HP:0000974)1.95362580
94Infantile muscular hypotonia (HP:0008947)1.94997474
95Chondrocalcinosis (HP:0000934)1.93675791
96Mild short stature (HP:0003502)1.92829928
97Persistence of primary teeth (HP:0006335)1.92703283
98Mitral regurgitation (HP:0001653)1.92553673
99Distal lower limb muscle weakness (HP:0009053)1.92001472
100Patent foramen ovale (HP:0001655)1.92001371
101Mitral stenosis (HP:0001718)1.90843204
102Nonimmune hydrops fetalis (HP:0001790)1.90728023
103Camptodactyly of toe (HP:0001836)1.89996150
104Abnormal delivery (HP:0001787)1.89872864
105Knee flexion contracture (HP:0006380)1.89851409
106Muscle fiber inclusion bodies (HP:0100299)1.89538309
107Osteolytic defects of the hand bones (HP:0009699)1.89175467
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.89175467
109Bowel diverticulosis (HP:0005222)1.88228735
110Tarsal synostosis (HP:0008368)1.87165877
111Breech presentation (HP:0001623)1.86747464
112Thin bony cortex (HP:0002753)1.84068172
113Genu recurvatum (HP:0002816)1.83293058
114Ulnar deviation of the wrist (HP:0003049)1.82753918
115Ulnar bowing (HP:0003031)1.80596324
116Abnormal platelet volume (HP:0011876)1.80453952
117Mesangial abnormality (HP:0001966)1.79752041
118Short 4th metacarpal (HP:0010044)1.79653417
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79653417
120Radial bowing (HP:0002986)1.79515751
121Venous abnormality (HP:0002624)1.78755440
122Limited hip movement (HP:0008800)1.78478826
123Abnormality of Sharpey fibers (HP:0100685)1.78290229
124Bundle branch block (HP:0011710)1.78276917
125Hypoplasia of the iris (HP:0007676)1.78041307
126Upper limb amyotrophy (HP:0009129)1.77168249
127Distal upper limb amyotrophy (HP:0007149)1.77168249
128Achilles tendon contracture (HP:0001771)1.76830512
129Limb-girdle muscle weakness (HP:0003325)1.71890001
130Short nail (HP:0001799)1.70205698
131Osteoarthritis (HP:0002758)1.69616378
132Emphysema (HP:0002097)1.68825846
133Inguinal hernia (HP:0000023)1.66568871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.88124645
2* MYLK4.33468305
3TESK13.78817913
4DMPK3.72593681
5OBSCN3.39874018
6LIMK13.32042352
7PIK3CA2.97973532
8TRIB32.97070164
9PDGFRA2.71238954
10PKN22.69770094
11PIK3CG2.59263426
12STK38L2.43314354
13DDR22.27606325
14EPHB22.19485415
15ZAK2.13025126
16ILK2.05831700
17LATS22.05358709
18PTK2B2.02276734
19STK241.92557076
20PAK31.84688891
21* PAK21.71550095
22LATS11.67073497
23TRPM71.64141767
24LMTK21.60288983
25NTRK11.57556939
26PRKD21.55283588
27RIPK11.36038348
28NUAK11.35079554
29MAPKAPK31.34427750
30MAP3K61.30812327
31PTK21.28036574
32ERN11.26030881
33EPHB11.25813174
34GRK71.23166236
35* ROCK11.10696481
36FER1.06280677
37MET1.01763703
38STK31.00221831
39LRRK20.98799134
40TGFBR20.96941462
41KDR0.95008233
42MAPK70.91814474
43AKT30.91187475
44TIE10.90401001
45PTK60.85666664
46ICK0.84555453
47EEF2K0.84247789
48PIM20.81066981
49MAP3K100.80128028
50FLT30.78566657
51PRKG20.77777368
52GRK50.76813119
53PRKD10.76320805
54PDK40.75603326
55PDK30.75603326
56MAP2K10.74842881
57NEK10.74396829
58FGFR10.74325691
59PDGFRB0.73815547
60MAP3K30.73098754
61ROCK20.72784518
62PDK20.71076947
63SIK10.70625453
64MAP3K70.70273991
65TESK20.69247379
66FGFR40.67639313
67GSK3A0.65448754
68ARAF0.64703464
69RPS6KA40.64655103
70* PAK10.63455550
71MARK20.62665078
72FRK0.62162152
73WNK40.59727457
74MAP2K30.59554766
75TAOK20.59533514
76MAPK40.59216525
77EPHA30.54235916
78PAK40.53619752
79PRKD30.53603046
80ZAP700.52562692
81PRPF4B0.49819509
82KIT0.49080060
83CAMK2G0.48806861
84BMX0.48710696
85EPHA20.48051807
86ABL20.47917027
87ERBB40.47625198
88PDPK10.46928051
89MTOR0.46557253
90RAF10.45967467
91MAPKAPK20.45443242
92PHKG10.44614485
93PHKG20.44614485
94* CDC42BPA0.44610612
95MELK0.43271764
96RPS6KA20.42426195
97SMG10.41559846
98* DAPK30.40873529
99MINK10.39921386
100BCKDK0.38741570
101NEK90.38727186
102STK390.38325493
103INSR0.36082331
104KSR20.35908965
105CAMK2D0.34552185
106DYRK1B0.34165380
107ERBB30.33373327
108MUSK0.32971472
109MAP3K130.31706668
110RPS6KL10.31031185
111RPS6KC10.31031185
112PINK10.30415466
113JAK10.30316679
114PRKCE0.30115048
115MAP3K50.28857259
116WNK10.28637118
117RET0.28492578
118MAP3K80.28462552
119TGFBR10.28144487
120MOS0.27771632
121RPS6KB20.27113046
122SRC0.26888215
123ADRBK10.25800343
124MAPK120.25458981
125RPS6KA60.25285706
126PRKACB0.24972238
127STK100.24831291
128PRKAA20.24092413
129STK380.23592160
130FYN0.23058446
131IGF1R0.21343579
132TAOK10.19848376

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.63850065
2Dilated cardiomyopathy_Homo sapiens_hsa054144.40370204
3Cardiac muscle contraction_Homo sapiens_hsa042603.61298495
4ECM-receptor interaction_Homo sapiens_hsa045123.58537567
5* Focal adhesion_Homo sapiens_hsa045103.21577390
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.20624957
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.10868714
8* Vascular smooth muscle contraction_Homo sapiens_hsa042702.06764053
9Adherens junction_Homo sapiens_hsa045202.04036879
10Proteoglycans in cancer_Homo sapiens_hsa052052.00978098
11Amoebiasis_Homo sapiens_hsa051461.99907726
12TGF-beta signaling pathway_Homo sapiens_hsa043501.98498786
13Protein digestion and absorption_Homo sapiens_hsa049741.87042233
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79221583
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.77860777
16* Tight junction_Homo sapiens_hsa045301.76788561
17Hippo signaling pathway_Homo sapiens_hsa043901.76450252
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76255630
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66513091
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60633124
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52803454
22Bladder cancer_Homo sapiens_hsa052191.51119707
23Small cell lung cancer_Homo sapiens_hsa052221.43857764
24Parkinsons disease_Homo sapiens_hsa050121.40545414
25* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.40318915
26* Leukocyte transendothelial migration_Homo sapiens_hsa046701.39806341
27* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.39528710
28Viral myocarditis_Homo sapiens_hsa054161.30953853
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30469634
30HIF-1 signaling pathway_Homo sapiens_hsa040661.22727852
31Carbon metabolism_Homo sapiens_hsa012001.20694068
32MicroRNAs in cancer_Homo sapiens_hsa052061.18291522
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18278605
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17772168
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.12055262
36Oxidative phosphorylation_Homo sapiens_hsa001901.11531553
37Basal cell carcinoma_Homo sapiens_hsa052171.08187382
38Platelet activation_Homo sapiens_hsa046111.06782346
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.03892126
40Malaria_Homo sapiens_hsa051441.03098306
41Other glycan degradation_Homo sapiens_hsa005111.02037489
42Alzheimers disease_Homo sapiens_hsa050100.93324262
43Prion diseases_Homo sapiens_hsa050200.91595840
44Huntingtons disease_Homo sapiens_hsa050160.91483379
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87695644
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84380885
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83825640
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78871246
49Pathways in cancer_Homo sapiens_hsa052000.78392619
50Hedgehog signaling pathway_Homo sapiens_hsa043400.77605063
51Melanoma_Homo sapiens_hsa052180.76995623
52Rap1 signaling pathway_Homo sapiens_hsa040150.76825820
53Galactose metabolism_Homo sapiens_hsa000520.76492267
54Chronic myeloid leukemia_Homo sapiens_hsa052200.73475895
55Complement and coagulation cascades_Homo sapiens_hsa046100.73103945
56GnRH signaling pathway_Homo sapiens_hsa049120.72797202
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71831241
58Fatty acid degradation_Homo sapiens_hsa000710.70498925
59Pyruvate metabolism_Homo sapiens_hsa006200.70325181
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67146037
61* Oxytocin signaling pathway_Homo sapiens_hsa049210.65048274
62Biosynthesis of amino acids_Homo sapiens_hsa012300.64878720
63Shigellosis_Homo sapiens_hsa051310.64873532
64Insulin resistance_Homo sapiens_hsa049310.64403255
65Gap junction_Homo sapiens_hsa045400.64174371
66Renin-angiotensin system_Homo sapiens_hsa046140.63068579
67Glucagon signaling pathway_Homo sapiens_hsa049220.62305834
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59851410
69HTLV-I infection_Homo sapiens_hsa051660.59628117
70Wnt signaling pathway_Homo sapiens_hsa043100.59110924
71Propanoate metabolism_Homo sapiens_hsa006400.57825465
72Fatty acid metabolism_Homo sapiens_hsa012120.56152681
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.55021815
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54635654
75* cAMP signaling pathway_Homo sapiens_hsa040240.54447279
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54361233
77Ras signaling pathway_Homo sapiens_hsa040140.54181043
78Toxoplasmosis_Homo sapiens_hsa051450.54096345
79Glutathione metabolism_Homo sapiens_hsa004800.54016844
80PPAR signaling pathway_Homo sapiens_hsa033200.53386533
81Cocaine addiction_Homo sapiens_hsa050300.52856196
82MAPK signaling pathway_Homo sapiens_hsa040100.51373933
83Melanogenesis_Homo sapiens_hsa049160.51193596
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50687096
85Thyroid hormone synthesis_Homo sapiens_hsa049180.50409740
86Prostate cancer_Homo sapiens_hsa052150.47245863
87Phagosome_Homo sapiens_hsa041450.46692981
88p53 signaling pathway_Homo sapiens_hsa041150.46604012
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.46117765
90Renin secretion_Homo sapiens_hsa049240.46014760
91VEGF signaling pathway_Homo sapiens_hsa043700.45785206
92Sulfur metabolism_Homo sapiens_hsa009200.45108449
93Phenylalanine metabolism_Homo sapiens_hsa003600.44329886
94Glioma_Homo sapiens_hsa052140.43660840
95AMPK signaling pathway_Homo sapiens_hsa041520.43633968
96Axon guidance_Homo sapiens_hsa043600.43325855
97Gastric acid secretion_Homo sapiens_hsa049710.42895825
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42695127
99Insulin signaling pathway_Homo sapiens_hsa049100.42586218
100Lysosome_Homo sapiens_hsa041420.41949125
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41945973
102Thyroid cancer_Homo sapiens_hsa052160.41861362
103Vibrio cholerae infection_Homo sapiens_hsa051100.41611367
104Arachidonic acid metabolism_Homo sapiens_hsa005900.40658020
105Pentose phosphate pathway_Homo sapiens_hsa000300.39138008
106Cholinergic synapse_Homo sapiens_hsa047250.39055368
107Renal cell carcinoma_Homo sapiens_hsa052110.38750567
108TNF signaling pathway_Homo sapiens_hsa046680.38545028
109Endometrial cancer_Homo sapiens_hsa052130.38315219
110Notch signaling pathway_Homo sapiens_hsa043300.37236822
111Pancreatic cancer_Homo sapiens_hsa052120.37212234
112Ovarian steroidogenesis_Homo sapiens_hsa049130.36952446
113Salmonella infection_Homo sapiens_hsa051320.36564552
114N-Glycan biosynthesis_Homo sapiens_hsa005100.35928467
115Acute myeloid leukemia_Homo sapiens_hsa052210.35712032
116Fructose and mannose metabolism_Homo sapiens_hsa000510.34036412
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33659036
118Starch and sucrose metabolism_Homo sapiens_hsa005000.33107638
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30531887
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29907935
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28376409
122Estrogen signaling pathway_Homo sapiens_hsa049150.27330639
123Endocytosis_Homo sapiens_hsa041440.27041709
124Calcium signaling pathway_Homo sapiens_hsa040200.26180405

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