MYLK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)8.70999080
2* cardiac myofibril assembly (GO:0055003)8.53171470
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.20901480
4negative regulation of potassium ion transmembrane transport (GO:1901380)7.46525564
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.31661140
6* myofibril assembly (GO:0030239)7.30930320
7tricarboxylic acid cycle (GO:0006099)7.13435636
8cardiac muscle contraction (GO:0060048)7.13341071
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.80959727
10cardiac muscle cell development (GO:0055013)6.78709339
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.68685083
12regulation of relaxation of muscle (GO:1901077)6.62478001
13regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.43968161
14regulation of actin filament-based movement (GO:1903115)6.40700362
15muscle filament sliding (GO:0030049)6.38828982
16actin-myosin filament sliding (GO:0033275)6.38828982
17cardiac cell development (GO:0055006)6.36785446
18cardiac muscle hypertrophy (GO:0003300)6.16051345
19cardiac muscle tissue morphogenesis (GO:0055008)6.15777791
20ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.06008970
21bundle of His cell to Purkinje myocyte communication (GO:0086069)6.05938317
22ventricular cardiac muscle cell action potential (GO:0086005)5.98395605
23adult heart development (GO:0007512)5.88391191
24striated muscle hypertrophy (GO:0014897)5.80971350
25regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.70058272
26heart trabecula formation (GO:0060347)5.64534552
27* actomyosin structure organization (GO:0031032)5.49138497
28heart process (GO:0003015)5.45631772
29heart contraction (GO:0060047)5.45631772
30muscle tissue morphogenesis (GO:0060415)5.44835536
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.39391118
32actin-mediated cell contraction (GO:0070252)5.29262022
33regulation of acyl-CoA biosynthetic process (GO:0050812)5.20511525
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.19235510
35regulation of the force of heart contraction (GO:0002026)5.18018059
36plasma membrane repair (GO:0001778)5.16364003
37muscle hypertrophy (GO:0014896)5.14935211
38regulation of striated muscle contraction (GO:0006942)5.13094669
39striated muscle contraction (GO:0006941)5.11729454
40carnitine shuttle (GO:0006853)5.10036551
41regulation of cell communication by electrical coupling (GO:0010649)5.09765366
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.07054107
43cell communication involved in cardiac conduction (GO:0086065)5.04432529
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99538292
45regulation of skeletal muscle contraction (GO:0014819)4.91254577
46regulation of coenzyme metabolic process (GO:0051196)4.76133382
47regulation of cofactor metabolic process (GO:0051193)4.76133382
48regulation of membrane repolarization (GO:0060306)4.74099019
49ATP synthesis coupled proton transport (GO:0015986)4.60065232
50energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60065232
51regulation of cardiac muscle cell contraction (GO:0086004)4.59467645
52sarcoplasmic reticulum calcium ion transport (GO:0070296)4.52475882
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.49341663
54fatty acid transmembrane transport (GO:1902001)4.49053033
55oxidative phosphorylation (GO:0006119)4.47209573
56regulation of cardiac muscle contraction (GO:0055117)4.46409832
57negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.46220229
58cell communication by electrical coupling (GO:0010644)4.45267216
59ventricular cardiac muscle cell development (GO:0055015)4.39250320
60relaxation of cardiac muscle (GO:0055119)4.38868150
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37720913
62respiratory electron transport chain (GO:0022904)4.37047530
63cardiac muscle hypertrophy in response to stress (GO:0014898)4.35745198
64muscle hypertrophy in response to stress (GO:0003299)4.35745198
65cardiac muscle adaptation (GO:0014887)4.35745198
66electron transport chain (GO:0022900)4.23907501
67regulation of heart rate (GO:0002027)4.18200062
68cardiac muscle cell action potential involved in contraction (GO:0086002)4.16381696
69regulation of cardioblast differentiation (GO:0051890)4.13613655
70cardiac muscle cell action potential (GO:0086001)4.11927104
71NADH metabolic process (GO:0006734)4.04920852
72regulation of ATPase activity (GO:0043462)4.03986355
73regulation of ATP catabolic process (GO:1903289)4.03986355
74negative regulation of striated muscle cell apoptotic process (GO:0010664)4.03124222
752-oxoglutarate metabolic process (GO:0006103)4.01602290
76negative regulation of potassium ion transport (GO:0043267)4.00923396
77* regulation of sarcomere organization (GO:0060297)3.99819162
78actin filament-based movement (GO:0030048)3.93195413
79regulation of sulfur metabolic process (GO:0042762)3.88510031
80kynurenine metabolic process (GO:0070189)3.87583838
81regulation of heart contraction (GO:0008016)3.85282898
82positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.85022860
83cardiac conduction (GO:0061337)3.83066870
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.81401314
85carnitine transmembrane transport (GO:1902603)3.80000820
86negative regulation of protein localization to cell surface (GO:2000009)3.74248689
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.73602459
88cellular ketone body metabolic process (GO:0046950)3.73289444
89striated muscle cell development (GO:0055002)3.62650688
90regulation of heart rate by cardiac conduction (GO:0086091)3.62019759
91behavioral response to nicotine (GO:0035095)3.61676354
92tryptophan catabolic process (GO:0006569)3.60108406
93indole-containing compound catabolic process (GO:0042436)3.60108406
94indolalkylamine catabolic process (GO:0046218)3.60108406
95trabecula formation (GO:0060343)3.58588298
96regulation of sequestering of triglyceride (GO:0010889)3.48924631
97creatine metabolic process (GO:0006600)3.48904400
98aspartate family amino acid catabolic process (GO:0009068)3.45645355
99positive regulation of heart rate (GO:0010460)3.45479040
100amino-acid betaine transport (GO:0015838)3.45429395
101carnitine transport (GO:0015879)3.45429395
102response to caffeine (GO:0031000)3.42897840
103positive regulation of heart contraction (GO:0045823)3.41647010
104fatty acid beta-oxidation (GO:0006635)3.38753168
105membrane depolarization during action potential (GO:0086010)3.38143316
106lysine metabolic process (GO:0006553)3.35805965
107lysine catabolic process (GO:0006554)3.35805965
108regulation of muscle contraction (GO:0006937)3.35663624
109potassium ion export (GO:0071435)3.35427408
110indolalkylamine metabolic process (GO:0006586)3.34216923
111positive regulation of cation channel activity (GO:2001259)3.34164385
112positive regulation of action potential (GO:0045760)3.33451311
113ketone body metabolic process (GO:1902224)3.30448984
114cardiac chamber formation (GO:0003207)3.27474880
115cilium or flagellum-dependent cell motility (GO:0001539)3.23882077
116interkinetic nuclear migration (GO:0022027)3.20657535
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11433410
118NAD biosynthetic process (GO:0009435)3.10004991
119regulation of action potential (GO:0098900)3.09469814
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06119364
121tryptophan metabolic process (GO:0006568)3.03699106
122reflex (GO:0060004)2.99315847
123regulation of hippo signaling (GO:0035330)2.95710156
124cAMP catabolic process (GO:0006198)2.92339751
125monoubiquitinated protein deubiquitination (GO:0035520)2.90696113
126establishment of protein localization to Golgi (GO:0072600)2.88016429
127negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86368340
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.86368340
129regulation of translation, ncRNA-mediated (GO:0045974)2.86368340
130detection of light stimulus involved in sensory perception (GO:0050962)2.86238511
131detection of light stimulus involved in visual perception (GO:0050908)2.86238511
132cardiac ventricle formation (GO:0003211)2.85893497
133protein K48-linked deubiquitination (GO:0071108)2.82301083
134response to inactivity (GO:0014854)2.82023256
135adrenergic receptor signaling pathway (GO:0071875)2.82020359
136protein K63-linked deubiquitination (GO:0070536)2.79722026
137protein K11-linked deubiquitination (GO:0035871)2.71594408
138regulation of calcium ion transmembrane transport (GO:1903169)2.70197302
139regulation of calcium ion transmembrane transporter activity (GO:1901019)2.70197302
140detection of calcium ion (GO:0005513)2.70158467
141positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.69450901
142auditory receptor cell stereocilium organization (GO:0060088)2.66452279
143action potential (GO:0001508)2.65718254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.68673151
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.68230724
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.11965930
4TBX20_22328084_ChIP-Seq_HEART_Mouse4.43978623
5TBX20_22080862_ChIP-Seq_HEART_Mouse4.43978623
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.43832182
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.29347875
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.59257625
9ZNF263_19887448_ChIP-Seq_K562_Human3.41937251
10GBX2_23144817_ChIP-Seq_PC3_Human3.27998897
11VDR_22108803_ChIP-Seq_LS180_Human3.06639500
12GATA4_21415370_ChIP-Seq_HL-1_Mouse3.03851716
13ESR1_20079471_ChIP-ChIP_T-47D_Human3.01988114
14GATA1_22025678_ChIP-Seq_K562_Human2.96417257
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.93659002
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88883659
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58538069
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55425632
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.42769525
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40325954
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30200685
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.26042148
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24230116
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.15220073
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.04132699
26IGF1R_20145208_ChIP-Seq_DFB_Human2.03256066
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01391833
28TAF15_26573619_Chip-Seq_HEK293_Human2.00280154
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99508604
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99220608
31DROSHA_22980978_ChIP-Seq_HELA_Human1.86116847
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85748833
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85070408
34SMAD4_21799915_ChIP-Seq_A2780_Human1.82998029
35STAT3_23295773_ChIP-Seq_U87_Human1.82002546
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81679347
37GATA1_19941826_ChIP-Seq_K562_Human1.80364520
38P300_19829295_ChIP-Seq_ESCs_Human1.78637351
39CLOCK_20551151_ChIP-Seq_293T_Human1.77788916
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77205587
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77107638
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.75271621
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74129681
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72364258
45ER_23166858_ChIP-Seq_MCF-7_Human1.70722641
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.68459991
47* TCF4_23295773_ChIP-Seq_U87_Human1.64479633
48AR_21572438_ChIP-Seq_LNCaP_Human1.63840372
49BCAT_22108803_ChIP-Seq_LS180_Human1.62796505
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61473227
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61421497
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60336800
53FUS_26573619_Chip-Seq_HEK293_Human1.59762586
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57295407
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.57236575
56EZH2_22144423_ChIP-Seq_EOC_Human1.56446579
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55761064
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55701722
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55225079
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55225079
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52033736
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.49406804
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.47698979
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43696001
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42393085
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42262980
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41699914
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40336935
69AR_25329375_ChIP-Seq_VCAP_Human1.38178180
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37897420
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.35790587
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.35228134
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34899881
74CBP_20019798_ChIP-Seq_JUKART_Human1.34899881
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34662666
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33322408
77EWS_26573619_Chip-Seq_HEK293_Human1.33277451
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31565859
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29485830
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.27823773
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.25915715
82REST_21632747_ChIP-Seq_MESCs_Mouse1.25718780
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24651231
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24459886
85TP53_16413492_ChIP-PET_HCT116_Human1.24291140
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23902403
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.23173832
88GATA2_19941826_ChIP-Seq_K562_Human1.22480279
89RUNX2_22187159_ChIP-Seq_PCA_Human1.22056506
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22025571
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.19747680
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19720272
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19615475
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.19070362
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.18142680
96TCF4_22108803_ChIP-Seq_LS180_Human1.17968640
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.16764611
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.16528369
99* ISL1_27105846_Chip-Seq_CPCs_Mouse1.16079642
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15792937
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15725967
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.14785059
103NANOG_19829295_ChIP-Seq_ESCs_Human1.14622925
104SOX2_19829295_ChIP-Seq_ESCs_Human1.14622925
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14434491
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13253711
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13215446
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.13159963
109* ARNT_22903824_ChIP-Seq_MCF-7_Human1.12732485
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.12724494
111AHR_22903824_ChIP-Seq_MCF-7_Human1.11645933
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11289407
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10827707
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09887778
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09800395
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09489642
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08876669
118KDM2B_26808549_Chip-Seq_DND41_Human1.08806799
119TBL1_22424771_ChIP-Seq_293T_Human1.08582390
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08074487
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08035404
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.07014837
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.06848350
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06281595
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05678043
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05601464
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04928917
128RNF2_27304074_Chip-Seq_NSC_Mouse1.04106909
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.03661622
130ATF3_27146783_Chip-Seq_COLON_Human1.02695561
131AR_19668381_ChIP-Seq_PC3_Human1.02201830
132RXR_22158963_ChIP-Seq_LIVER_Mouse1.02044357
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01943685
134KDM2B_26808549_Chip-Seq_REH_Human1.01886144
135ELK3_25401928_ChIP-Seq_HUVEC_Human1.01710050
136SPI1_20517297_ChIP-Seq_HL60_Human1.01486700
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01067904
138TP63_22573176_ChIP-Seq_HFKS_Human1.00294653
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99752422
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.99112061
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98839196
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98038394
143EED_16625203_ChIP-ChIP_MESCs_Mouse0.98018132
144CDX2_22108803_ChIP-Seq_LS180_Human0.97890587
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.97887732
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97741638
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97546265
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97389938
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97163910
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.97003956
151GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95583427
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93466576
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92460116
154TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90749063
155AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90675865
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89357382
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88870836
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88582136
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87133990
160ZNF274_21170338_ChIP-Seq_K562_Hela0.86954576
161PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86829802
162* CTCF_27219007_Chip-Seq_Bcells_Human0.86163317
163P68_20966046_ChIP-Seq_HELA_Human0.85728378
164RACK7_27058665_Chip-Seq_MCF-7_Human0.85035208
165SPI1_23127762_ChIP-Seq_K562_Human0.83741398
166RUNX1_27514584_Chip-Seq_MCF-7_Human0.83651955
167* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83207354
168FOXA2_19822575_ChIP-Seq_HepG2_Human0.82555593
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80492516
170ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79675419
171CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79451845
172CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77327807
173TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76640318
174LXR_22292898_ChIP-Seq_THP-1_Human0.76198646
175SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76068460
176STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.75590400
177WT1_19549856_ChIP-ChIP_CCG9911_Human0.75332495
178OCT4_20526341_ChIP-Seq_ESCs_Human0.75123064
179BCOR_27268052_Chip-Seq_Bcells_Human0.74458794
180SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72643057
181SMAD3_21741376_ChIP-Seq_HESCs_Human0.71408259
182DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71070303
183BCL6_27268052_Chip-Seq_Bcells_Human0.70936309
184KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70539786
185SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69154278
186CTCF_21964334_Chip-Seq_Bcells_Human0.69043217
187EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.68730965
188SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67957976
189FOXH1_21741376_ChIP-Seq_ESCs_Human0.67252988
190GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66763936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.77441324
2MP0004084_abnormal_cardiac_muscle6.33819453
3MP0003646_muscle_fatigue5.23288411
4MP0004215_abnormal_myocardial_fiber5.20871370
5MP0000751_myopathy4.73608839
6MP0004036_abnormal_muscle_relaxation4.33744539
7MP0005330_cardiomyopathy4.15250755
8MP0000749_muscle_degeneration3.62587292
9MP0008775_abnormal_heart_ventricle3.44008810
10MP0002972_abnormal_cardiac_muscle3.40192434
11MP0003137_abnormal_impulse_conducting3.11310136
12MP0004087_abnormal_muscle_fiber3.00791919
13MP0005385_cardiovascular_system_phenoty2.82948174
14MP0001544_abnormal_cardiovascular_syste2.82948174
15MP0010630_abnormal_cardiac_muscle2.81082485
16MP0005620_abnormal_muscle_contractility2.67091564
17MP0004484_altered_response_of2.63628084
18MP0006138_congestive_heart_failure2.58584141
19MP0003828_pulmonary_edema2.49734231
20MP0000750_abnormal_muscle_regeneration2.48447488
21MP0004130_abnormal_muscle_cell2.46554691
22MP0004085_abnormal_heartbeat2.38932621
23MP0002106_abnormal_muscle_physiology2.30674603
24MP0004510_myositis2.23347816
25MP0000569_abnormal_digit_pigmentation2.20739257
26MP0003221_abnormal_cardiomyocyte_apopto2.15425999
27MP0002269_muscular_atrophy2.10815133
28MP0006036_abnormal_mitochondrial_physio1.87437299
29MP0005369_muscle_phenotype1.83537962
30MP0002127_abnormal_cardiovascular_syste1.81755595
31MP0003195_calcinosis1.78546658
32MP0005551_abnormal_eye_electrophysiolog1.76252028
33MP0009046_muscle_twitch1.71283259
34MP0009745_abnormal_behavioral_response1.69428338
35MP0000759_abnormal_skeletal_muscle1.69419535
36MP0001501_abnormal_sleep_pattern1.68749248
37MP0004145_abnormal_muscle_electrophysio1.68395867
38MP0003136_yellow_coat_color1.65313168
39MP0000747_muscle_weakness1.64315063
40MP0003567_abnormal_fetal_cardiomyocyte1.56542228
41MP0003950_abnormal_plasma_membrane1.54191019
42MP0004233_abnormal_muscle_weight1.50526854
43MP0004142_abnormal_muscle_tone1.36533310
44MP0002638_abnormal_pupillary_reflex1.35841288
45MP0006276_abnormal_autonomic_nervous1.33964853
46MP0002332_abnormal_exercise_endurance1.33256533
47MP0002102_abnormal_ear_morphology1.30320173
48MP0005666_abnormal_adipose_tissue1.30125318
49MP0001486_abnormal_startle_reflex1.29335919
50MP0001485_abnormal_pinna_reflex1.28131930
51MP0001968_abnormal_touch/_nociception1.27349581
52MP0000343_altered_response_to1.26012628
53MP0000266_abnormal_heart_morphology1.25894309
54MP0002272_abnormal_nervous_system1.23706837
55MP0002735_abnormal_chemical_nociception1.23672130
56MP0005410_abnormal_fertilization1.22068876
57MP0010368_abnormal_lymphatic_system1.21235893
58MP0005165_increased_susceptibility_to1.19795019
59MP0005253_abnormal_eye_physiology1.19524857
60MP0003045_fibrosis1.19070396
61MP0006035_abnormal_mitochondrial_morpho1.13442293
62MP0003279_aneurysm1.10323376
63MP0003878_abnormal_ear_physiology1.10000569
64MP0005377_hearing/vestibular/ear_phenot1.10000569
65MP0004147_increased_porphyrin_level1.09790222
66MP0002064_seizures1.09716658
67MP0005670_abnormal_white_adipose1.06443814
68MP0001984_abnormal_olfaction1.03231213
69MP0002234_abnormal_pharynx_morphology1.00184121
70MP0008877_abnormal_DNA_methylation0.98254179
71MP0002572_abnormal_emotion/affect_behav0.97745878
72MP0005645_abnormal_hypothalamus_physiol0.97195141
73MP0002067_abnormal_sensory_capabilities0.95842556
74MP0000427_abnormal_hair_cycle0.93778821
75MP0001970_abnormal_pain_threshold0.91499643
76MP0006072_abnormal_retinal_apoptosis0.91235287
77MP0002736_abnormal_nociception_after0.90305769
78MP0008872_abnormal_physiological_respon0.86867752
79MP0003566_abnormal_cell_adhesion0.85877891
80MP0005167_abnormal_blood-brain_barrier0.85772705
81MP0000372_irregular_coat_pigmentation0.85738385
82MP0002128_abnormal_blood_circulation0.85488951
83MP0000230_abnormal_systemic_arterial0.85163484
84MP0003635_abnormal_synaptic_transmissio0.82960454
85MP0001986_abnormal_taste_sensitivity0.82535133
86MP0005375_adipose_tissue_phenotype0.82505037
87MP0004185_abnormal_adipocyte_glucose0.82087142
88MP0002733_abnormal_thermal_nociception0.81733075
89MP0003806_abnormal_nucleotide_metabolis0.81302575
90MP0005266_abnormal_metabolism0.79841339
91MP0003879_abnormal_hair_cell0.78535894
92MP0001440_abnormal_grooming_behavior0.76481491
93MP0002557_abnormal_social/conspecific_i0.75173930
94MP0008057_abnormal_DNA_replication0.75051394
95MP0002876_abnormal_thyroid_physiology0.74667329
96MP0005451_abnormal_body_composition0.72496364
97MP0005646_abnormal_pituitary_gland0.71944144
98MP0003698_abnormal_male_reproductive0.70690587
99MP0005174_abnormal_tail_pigmentation0.70134642
100MP0003656_abnormal_erythrocyte_physiolo0.69600900
101MP0005623_abnormal_meninges_morphology0.69030642
102MP0002734_abnormal_mechanical_nocicepti0.68646024
103MP0000631_abnormal_neuroendocrine_gland0.68363013
104MP0005423_abnormal_somatic_nervous0.67033173
105MP0002063_abnormal_learning/memory/cond0.66695546
106MP0001879_abnormal_lymphatic_vessel0.65614239
107MP0000767_abnormal_smooth_muscle0.63525095
108MP0001963_abnormal_hearing_physiology0.62701443
109MP0002108_abnormal_muscle_morphology0.61626983
110MP0004043_abnormal_pH_regulation0.60730587
111MP0002168_other_aberrant_phenotype0.60486913
112MP0002229_neurodegeneration0.60413363
113MP0004272_abnormal_basement_membrane0.59716700
114MP0003787_abnormal_imprinting0.59611049
115MP0000026_abnormal_inner_ear0.59532996
116MP0002822_catalepsy0.58613533
117MP0005171_absent_coat_pigmentation0.57981859
118MP0003705_abnormal_hypodermis_morpholog0.55021675
119MP0003984_embryonic_growth_retardation0.54798164
120MP0002088_abnormal_embryonic_growth/wei0.53478984
121MP0002909_abnormal_adrenal_gland0.52893839
122MP0002925_abnormal_cardiovascular_devel0.51931485
123MP0005319_abnormal_enzyme/_coenzyme0.50818157
124MP0005187_abnormal_penis_morphology0.48979562
125MP0000003_abnormal_adipose_tissue0.47202051
126MP0002078_abnormal_glucose_homeostasis0.43371281
127MP0001784_abnormal_fluid_regulation0.42397496
128MP0009384_cardiac_valve_regurgitation0.41420455
129MP0008438_abnormal_cutaneous_collagen0.41182960
130MP0001614_abnormal_blood_vessel0.40694548
131MP0002971_abnormal_brown_adipose0.38764305
132MP0000013_abnormal_adipose_tissue0.32952674
133MP0000733_abnormal_muscle_development0.32023127
134MP0001672_abnormal_embryogenesis/_devel0.31922462
135MP0005380_embryogenesis_phenotype0.31922462
136MP0005535_abnormal_body_temperature0.31164914
137MP0005595_abnormal_vascular_smooth0.29834240
138MP0005275_abnormal_skin_tensile0.29473948
139MP0008961_abnormal_basal_metabolism0.27836238
140MP0004924_abnormal_behavior0.27768317
141MP0005386_behavior/neurological_phenoty0.27768317
142MP0003948_abnormal_gas_homeostasis0.27353472
143MP0002877_abnormal_melanocyte_morpholog0.26932313
144MP0001727_abnormal_embryo_implantation0.26820391
145MP0005083_abnormal_biliary_tract0.25205631
146MP0005085_abnormal_gallbladder_physiolo0.25169119
147MP0005584_abnormal_enzyme/coenzyme_acti0.23276055
148MP0005388_respiratory_system_phenotype0.21638442
149MP0002133_abnormal_respiratory_system0.21638442
150MP0002118_abnormal_lipid_homeostasis0.21531453
151MP0005332_abnormal_amino_acid0.20403099
152MP0000249_abnormal_blood_vessel0.20092454
153MP0009840_abnormal_foam_cell0.20045408
154MP0005334_abnormal_fat_pad0.19938879
155MP0002295_abnormal_pulmonary_circulatio0.19784666
156MP0000358_abnormal_cell_content/0.18106014

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.54635865
2Ventricular tachycardia (HP:0004756)7.43580636
3Atrial fibrillation (HP:0005110)6.70468809
4Primary atrial arrhythmia (HP:0001692)6.26988307
5Supraventricular tachycardia (HP:0004755)6.07843399
6Calf muscle hypertrophy (HP:0008981)6.01683354
7Supraventricular arrhythmia (HP:0005115)5.95134541
8Lipoatrophy (HP:0100578)5.70449890
9Exercise-induced muscle cramps (HP:0003710)5.45268807
10Syncope (HP:0001279)5.35172266
11Right ventricular cardiomyopathy (HP:0011663)5.35151137
12Muscle hypertrophy of the lower extremities (HP:0008968)5.34928486
13Exercise-induced myalgia (HP:0003738)5.07117641
14Abnormality of the calf musculature (HP:0001430)5.03344380
15Subaortic stenosis (HP:0001682)4.96450277
16Abnormality of the left ventricular outflow tract (HP:0011103)4.96450277
17Muscle fiber splitting (HP:0003555)4.86382643
18Myoglobinuria (HP:0002913)4.83461682
19Palpitations (HP:0001962)4.80711056
20Dilated cardiomyopathy (HP:0001644)4.73758756
21Genetic anticipation (HP:0003743)4.70180856
22Bundle branch block (HP:0011710)4.66654048
23Prolonged QT interval (HP:0001657)4.56106339
24Hyporeflexia of lower limbs (HP:0002600)4.38257533
25Ventricular arrhythmia (HP:0004308)4.38231985
26Ventricular fibrillation (HP:0001663)4.00245199
27Heart block (HP:0012722)3.98306891
28Atrioventricular block (HP:0001678)3.92682524
29Asymmetric septal hypertrophy (HP:0001670)3.86289147
30Progressive cerebellar ataxia (HP:0002073)3.80493480
31Abnormal atrioventricular conduction (HP:0005150)3.75143849
32Rhabdomyolysis (HP:0003201)3.72496608
33EMG: myopathic abnormalities (HP:0003458)3.66290873
34Hyperventilation (HP:0002883)3.63301801
35Gaze-evoked nystagmus (HP:0000640)3.54553835
36Hepatic necrosis (HP:0002605)3.39306649
37Pancreatic cysts (HP:0001737)3.36938730
38Abnormal mitochondria in muscle tissue (HP:0008316)3.32851283
39Abnormal EKG (HP:0003115)3.29871520
40Increased connective tissue (HP:0009025)3.29111642
41Acute necrotizing encephalopathy (HP:0006965)3.27280018
42Left ventricular hypertrophy (HP:0001712)3.13681344
43Attenuation of retinal blood vessels (HP:0007843)3.05738328
44Hypoglycemic coma (HP:0001325)3.05126221
45Congenital stationary night blindness (HP:0007642)3.01943053
46Pancreatic fibrosis (HP:0100732)2.99123278
47Myotonia (HP:0002486)2.92639902
48Ketoacidosis (HP:0001993)2.92129725
49Hepatocellular necrosis (HP:0001404)2.91527457
50Abnormality of the renal cortex (HP:0011035)2.89029737
51Abnormality of the ischium (HP:0003174)2.85633712
52True hermaphroditism (HP:0010459)2.83577041
53Palmoplantar keratoderma (HP:0000982)2.83525882
54Acute encephalopathy (HP:0006846)2.81411668
55Nephronophthisis (HP:0000090)2.81160294
56Difficulty running (HP:0009046)2.74191392
57Abnormality of fatty-acid metabolism (HP:0004359)2.72188961
58Progressive macrocephaly (HP:0004481)2.71757144
59Abnormality of midbrain morphology (HP:0002418)2.71131402
60Molar tooth sign on MRI (HP:0002419)2.71131402
61Mitochondrial inheritance (HP:0001427)2.70019092
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69658257
63Dicarboxylic aciduria (HP:0003215)2.69658257
64Chronic hepatic failure (HP:0100626)2.68547359
65Ragged-red muscle fibers (HP:0003200)2.68512826
66Protruding tongue (HP:0010808)2.67977675
67Conjunctival hamartoma (HP:0100780)2.64034821
68Increased CSF lactate (HP:0002490)2.61977796
69Cerebral edema (HP:0002181)2.61702815
70Decreased circulating renin level (HP:0003351)2.61567156
71Clumsiness (HP:0002312)2.60351982
72Increased muscle lipid content (HP:0009058)2.57561073
73Abnormality of the renal medulla (HP:0100957)2.55799553
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.51586812
75Congenital sensorineural hearing impairment (HP:0008527)2.46616411
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.44865103
77Muscle fiber inclusion bodies (HP:0100299)2.44733699
78Distal lower limb muscle weakness (HP:0009053)2.40368010
79Difficulty climbing stairs (HP:0003551)2.40319364
80Bony spicule pigmentary retinopathy (HP:0007737)2.39630206
81Polydipsia (HP:0001959)2.38851867
82Abnormal drinking behavior (HP:0030082)2.38851867
83Febrile seizures (HP:0002373)2.37857410
84Lactic acidosis (HP:0003128)2.35457857
85Sudden cardiac death (HP:0001645)2.32572128
86Broad-based gait (HP:0002136)2.32503760
87Tubular atrophy (HP:0000092)2.30564491
88Pheochromocytoma (HP:0002666)2.30224284
89Abnormality of alanine metabolism (HP:0010916)2.29661451
90Hyperalaninemia (HP:0003348)2.29661451
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29661451
92Exercise intolerance (HP:0003546)2.29444051
93Cystic liver disease (HP:0006706)2.29417225
94Increased intramyocellular lipid droplets (HP:0012240)2.28026771
95Hyperkalemia (HP:0002153)2.27181280
96Respiratory failure (HP:0002878)2.26925459
97Fair hair (HP:0002286)2.26148822
98Neoplasm of the adrenal gland (HP:0100631)2.25426971
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.22066703
100Testicular atrophy (HP:0000029)2.16236399
101Nemaline bodies (HP:0003798)2.15462073
102Limb-girdle muscle atrophy (HP:0003797)2.15253168
103Ketosis (HP:0001946)2.12352144
104Abnormality of glycolysis (HP:0004366)2.11710395
105Increased serum pyruvate (HP:0003542)2.11710395
106Neoplasm of head and neck (HP:0012288)2.11408943
107Esophageal neoplasm (HP:0100751)2.11408943
108Congestive heart failure (HP:0001635)2.11321880
109Areflexia of lower limbs (HP:0002522)2.10429535
110Neuroendocrine neoplasm (HP:0100634)2.08904933
111Type II lissencephaly (HP:0007260)2.07094420
112Generalized aminoaciduria (HP:0002909)2.04830838
113Hamartoma of the eye (HP:0010568)2.04504053
114EMG: neuropathic changes (HP:0003445)2.03865782
115Type 1 muscle fiber predominance (HP:0003803)2.02924726
116Abolished electroretinogram (ERG) (HP:0000550)2.01796597
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00796635
118Muscle stiffness (HP:0003552)2.00531492
119Abnormality of the foot musculature (HP:0001436)1.98091652
120Abnormality of the pubic bones (HP:0003172)1.98052202
121Increased variability in muscle fiber diameter (HP:0003557)1.97632116
122Inability to walk (HP:0002540)1.97431282
123Nausea (HP:0002018)1.96499652
124Absent/shortened dynein arms (HP:0200106)1.95491370
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.95491370
126Dysmetric saccades (HP:0000641)1.95408479
127Neck muscle weakness (HP:0000467)1.95219436
128Cerebellar dysplasia (HP:0007033)1.95123175
129Diaphragmatic weakness (HP:0009113)1.94907324
130Lipid accumulation in hepatocytes (HP:0006561)1.93743955
131Congenital malformation of the right heart (HP:0011723)1.93237697
132Double outlet right ventricle (HP:0001719)1.93237697
133Chorioretinal atrophy (HP:0000533)1.91626418
134Hyperinsulinemic hypoglycemia (HP:0000825)1.90346854
135Medial flaring of the eyebrow (HP:0010747)1.89730278
136Renal cortical cysts (HP:0000803)1.88045079
137Large for gestational age (HP:0001520)1.87372139
138Sclerocornea (HP:0000647)1.87002453
139Multiple enchondromatosis (HP:0005701)1.84187923
140Postural instability (HP:0002172)1.82898670
141Focal seizures (HP:0007359)1.81928045
142Dialeptic seizures (HP:0011146)1.81490029
143Foot dorsiflexor weakness (HP:0009027)1.81002352
144Absent speech (HP:0001344)1.80872581
145Hyperammonemia (HP:0001987)1.80683291
146Congenital hepatic fibrosis (HP:0002612)1.80656872
147Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80340391
148Lymphangioma (HP:0100764)1.78969292
149Hip contracture (HP:0003273)1.78364247
150Central scotoma (HP:0000603)1.77615597
151Polyuria (HP:0000103)1.77546570
152Tinnitus (HP:0000360)1.77419397
153Cholelithiasis (HP:0001081)1.76499641
154Facial diplegia (HP:0001349)1.76355406
155Hypoplastic ischia (HP:0003175)1.74498967
156Hypoplastic left heart (HP:0004383)1.73415854
157Decreased central vision (HP:0007663)1.72891784
158Absence seizures (HP:0002121)1.72725927
159Abnormal ciliary motility (HP:0012262)1.72445006
160Steppage gait (HP:0003376)1.72224513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.06306899
2TTN5.44486109
3MYLK4.31606908
4LMTK24.27104861
5OBSCN4.00696371
6PDK33.72534944
7PDK43.72534944
8PKN23.65056312
9PHKG13.61893121
10PHKG23.61893121
11DMPK2.95829393
12STK242.70259430
13TRIB32.58483225
14ACVR1B2.54188333
15NEK12.46420688
16BCKDK2.44911817
17BMPR1B2.39765663
18TIE12.38214127
19PIK3CA2.32138280
20PDK22.19906630
21ADRBK22.14466875
22MUSK1.99888574
23GRK71.95759495
24PINK11.82353210
25PAK31.45348121
26WNK31.43205051
27MAPK131.42955390
28STK41.42545260
29GRK11.41126374
30ILK1.37420472
31MARK11.37350551
32CASK1.34941222
33CAMK2D1.33491893
34PRKD11.33355058
35OXSR11.28875658
36PIK3CG1.28508011
37ZAK1.26625559
38NTRK31.26337775
39FLT31.25890615
40CDC42BPA1.20673948
41MAP4K21.19599501
42WNK41.17122131
43TRPM71.11051422
44NUAK11.10847529
45TAOK31.02465266
46MAP3K41.01903043
47ROCK11.00655044
48INSRR1.00569248
49AKT30.98742689
50STK38L0.98263144
51DAPK20.94048049
52CAMK40.89594387
53DAPK30.89544589
54MKNK20.88870441
55MAP3K70.87029396
56MAP3K50.85832687
57PRKAA10.85680534
58PNCK0.85545476
59MAPK120.84708890
60TNIK0.84289322
61KDR0.83216708
62TLK10.82278880
63PRKAA20.81018333
64MAPKAPK30.77383902
65CAMK1G0.75950826
66PLK40.71086319
67SIK20.69263356
68PDGFRA0.68992151
69CAMK10.67994708
70PKN10.67511991
71RIPK10.66859024
72WNK10.64911802
73TGFBR20.64618717
74STK110.64444912
75TXK0.63454616
76CAMK2A0.62540145
77RPS6KL10.62361918
78RPS6KC10.62361918
79SGK20.61079109
80CAMK1D0.60960027
81STK30.59262154
82ROCK20.58416161
83MAP2K30.57957749
84NME20.55230558
85MAP3K30.55190594
86STK380.54745439
87NLK0.54573937
88MAPK150.54535194
89FER0.53687212
90RPS6KA60.53602502
91PRKCG0.52807092
92PTK2B0.52510138
93STK390.51834967
94PRKACB0.50737958
95NEK90.50257533
96MAP2K60.48203402
97MAP2K10.46687121
98NEK20.45169364
99PRKACG0.43909281
100PRKCE0.43816317
101TEC0.41005838
102TNK20.40348808
103PRKACA0.40041361
104NTRK20.40033927
105EPHA30.38979524
106SGK4940.36339900
107SGK2230.36339900
108ITK0.34658134
109PDPK10.34568552
110MAPKAPK50.33649239
111PDK10.33185783
112PRKD30.30547358
113MAPK70.29822151
114AKT20.29498005
115PRKCA0.29460446
116CAMKK20.29099176
117EPHB10.28615043
118ERBB20.28195338
119RPS6KA10.27004923
120PRKCH0.27004245
121ICK0.26238740
122PLK20.25988567
123CAMK2G0.25506444
124PTK60.25145258
125MAP3K100.24509405
126PRKG20.23874046
127RET0.23108274
128LRRK20.22513541
129JAK10.17489567
130SGK30.16004222
131MAPK110.15677492
132PRKG10.14741400
133JAK20.13814372
134MTOR0.13150626
135SIK10.12448530
136UHMK10.11869962
137PRKCQ0.11568161
138SGK10.10397597
139RPS6KA30.10238699
140TGFBR10.09719048
141ADRBK10.08493077
142CDK40.08462763
143MARK30.08287988
144MAPKAPK20.07855141
145RPS6KA20.07790540
146PDGFRB0.07413656
147LATS10.07368675
148LIMK10.07063061
149EPHB20.06769047
150MAP3K110.05225707

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.34259796
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.48099790
3Cardiac muscle contraction_Homo sapiens_hsa042604.35468831
4Dilated cardiomyopathy_Homo sapiens_hsa054143.66770655
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.54302772
6Parkinsons disease_Homo sapiens_hsa050123.40781105
7Propanoate metabolism_Homo sapiens_hsa006403.39098475
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28485268
9Oxidative phosphorylation_Homo sapiens_hsa001903.27045497
10Fatty acid degradation_Homo sapiens_hsa000713.10237042
11Carbon metabolism_Homo sapiens_hsa012002.63910359
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43558159
13Alzheimers disease_Homo sapiens_hsa050102.43267020
14Fatty acid metabolism_Homo sapiens_hsa012122.32530126
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29483062
16Linoleic acid metabolism_Homo sapiens_hsa005912.26683883
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26318760
18Nicotine addiction_Homo sapiens_hsa050332.16413992
19Huntingtons disease_Homo sapiens_hsa050162.15641898
20Phototransduction_Homo sapiens_hsa047442.03773924
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03343208
22Morphine addiction_Homo sapiens_hsa050322.02060623
23Nitrogen metabolism_Homo sapiens_hsa009101.94381468
24Pyruvate metabolism_Homo sapiens_hsa006201.94035077
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69842767
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69604544
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65950562
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62156216
29Olfactory transduction_Homo sapiens_hsa047401.61481867
30Viral myocarditis_Homo sapiens_hsa054161.60146223
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57343161
32GABAergic synapse_Homo sapiens_hsa047271.54423075
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47506061
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.47408323
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45948130
36Butanoate metabolism_Homo sapiens_hsa006501.45350871
37Fatty acid elongation_Homo sapiens_hsa000621.44450979
38Glutamatergic synapse_Homo sapiens_hsa047241.42919128
39Selenocompound metabolism_Homo sapiens_hsa004501.38693546
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35226455
41Serotonergic synapse_Homo sapiens_hsa047261.32616113
42Salivary secretion_Homo sapiens_hsa049701.32469881
43Ether lipid metabolism_Homo sapiens_hsa005651.30510425
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23847028
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22386967
46PPAR signaling pathway_Homo sapiens_hsa033201.02640159
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.00151397
48Insulin resistance_Homo sapiens_hsa049310.98243974
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97249652
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95921495
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93960453
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.93836796
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.90385773
54Glucagon signaling pathway_Homo sapiens_hsa049220.90067383
55Starch and sucrose metabolism_Homo sapiens_hsa005000.87995932
56Tryptophan metabolism_Homo sapiens_hsa003800.87673063
57Histidine metabolism_Homo sapiens_hsa003400.84343471
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83168740
59Lysine degradation_Homo sapiens_hsa003100.82455812
60* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81685652
61* Gastric acid secretion_Homo sapiens_hsa049710.77716516
62beta-Alanine metabolism_Homo sapiens_hsa004100.77134461
63Arachidonic acid metabolism_Homo sapiens_hsa005900.76662454
64Insulin signaling pathway_Homo sapiens_hsa049100.76055596
65HIF-1 signaling pathway_Homo sapiens_hsa040660.73667229
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71971175
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.71577230
68Retinol metabolism_Homo sapiens_hsa008300.66918882
69Arginine biosynthesis_Homo sapiens_hsa002200.65230634
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65038016
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64675741
72Chemical carcinogenesis_Homo sapiens_hsa052040.64397802
73Dopaminergic synapse_Homo sapiens_hsa047280.63727340
74Homologous recombination_Homo sapiens_hsa034400.62534345
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62375640
76AMPK signaling pathway_Homo sapiens_hsa041520.61352739
77Caffeine metabolism_Homo sapiens_hsa002320.60522082
78Long-term depression_Homo sapiens_hsa047300.59495679
79Arginine and proline metabolism_Homo sapiens_hsa003300.57362899
80Galactose metabolism_Homo sapiens_hsa000520.55712607
81Peroxisome_Homo sapiens_hsa041460.54151377
82Type II diabetes mellitus_Homo sapiens_hsa049300.53927108
83Regulation of autophagy_Homo sapiens_hsa041400.51880428
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.51830401
85Cocaine addiction_Homo sapiens_hsa050300.51152650
86* Focal adhesion_Homo sapiens_hsa045100.50929594
87Fanconi anemia pathway_Homo sapiens_hsa034600.50679555
88* Calcium signaling pathway_Homo sapiens_hsa040200.50568391
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50487385
90Phenylalanine metabolism_Homo sapiens_hsa003600.49479816
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49464978
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48921946
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47798887
94Mineral absorption_Homo sapiens_hsa049780.45374403
95Amphetamine addiction_Homo sapiens_hsa050310.42779831
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41881805
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41559018
98ECM-receptor interaction_Homo sapiens_hsa045120.40909697
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39683061
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37994604
101Fructose and mannose metabolism_Homo sapiens_hsa000510.37841340
102Fatty acid biosynthesis_Homo sapiens_hsa000610.37624538
103Tight junction_Homo sapiens_hsa045300.37369332
104cAMP signaling pathway_Homo sapiens_hsa040240.36982084
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36440516
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36071324
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.35526562
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33016272
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.32429817
110MAPK signaling pathway_Homo sapiens_hsa040100.31778094
111* Oxytocin signaling pathway_Homo sapiens_hsa049210.31000594
112Metabolic pathways_Homo sapiens_hsa011000.30005713
113Renin secretion_Homo sapiens_hsa049240.29736661
114* Vascular smooth muscle contraction_Homo sapiens_hsa042700.27895348
115Adherens junction_Homo sapiens_hsa045200.26768717
116Amoebiasis_Homo sapiens_hsa051460.20436335
117Insulin secretion_Homo sapiens_hsa049110.19544312
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17275258
119Tyrosine metabolism_Homo sapiens_hsa003500.14525629
120Circadian entrainment_Homo sapiens_hsa047130.13645277
121Fat digestion and absorption_Homo sapiens_hsa049750.13338198
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.12577522
123Renal cell carcinoma_Homo sapiens_hsa052110.09383006
124Small cell lung cancer_Homo sapiens_hsa052220.08968135
125Circadian rhythm_Homo sapiens_hsa047100.08365495
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08271076
127Proteoglycans in cancer_Homo sapiens_hsa052050.07931795
128Ovarian steroidogenesis_Homo sapiens_hsa049130.06465088
129Dorso-ventral axis formation_Homo sapiens_hsa043200.05402897
130mTOR signaling pathway_Homo sapiens_hsa041500.04425122
131* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04167279
132Gap junction_Homo sapiens_hsa045400.02904900
133Pentose phosphate pathway_Homo sapiens_hsa000300.01960392
134Toxoplasmosis_Homo sapiens_hsa051450.01923508
135Bile secretion_Homo sapiens_hsa049760.01748489
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.01498343
137Pancreatic secretion_Homo sapiens_hsa049720.01190332
138ABC transporters_Homo sapiens_hsa020100.00804364
139GnRH signaling pathway_Homo sapiens_hsa04912-0.0624767
140* Platelet activation_Homo sapiens_hsa04611-0.0572208
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0506638
142Taste transduction_Homo sapiens_hsa04742-0.0398670
143Cholinergic synapse_Homo sapiens_hsa04725-0.0275553
144FoxO signaling pathway_Homo sapiens_hsa04068-0.0220612
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0193399
146PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0180463
147Glycerolipid metabolism_Homo sapiens_hsa00561-0.0131553
148VEGF signaling pathway_Homo sapiens_hsa04370-0.0082393

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