

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of skeletal muscle contraction (GO:0014819) | 8.30240783 |
| 2 | muscle filament sliding (GO:0030049) | 7.78152764 |
| 3 | actin-myosin filament sliding (GO:0033275) | 7.78152764 |
| 4 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 7.23907361 |
| 5 | skeletal muscle contraction (GO:0003009) | 6.92755769 |
| 6 | actin-mediated cell contraction (GO:0070252) | 6.69370321 |
| 7 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 6.37132080 |
| 8 | skeletal muscle adaptation (GO:0043501) | 5.90620464 |
| 9 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.57603772 |
| 10 | sarcomere organization (GO:0045214) | 5.48411299 |
| 11 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.20585887 |
| 12 | myofibril assembly (GO:0030239) | 5.10053031 |
| 13 | creatine metabolic process (GO:0006600) | 5.09280790 |
| 14 | regulation of cell communication by electrical coupling (GO:0010649) | 5.08875062 |
| 15 | actin filament-based movement (GO:0030048) | 4.97767412 |
| 16 | striated muscle contraction (GO:0006941) | 4.84650084 |
| 17 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.74907435 |
| 18 | response to inactivity (GO:0014854) | 4.55128950 |
| 19 | plasma membrane repair (GO:0001778) | 4.51306796 |
| 20 | skeletal muscle tissue development (GO:0007519) | 4.48265850 |
| 21 | negative regulation of protein localization to cell surface (GO:2000009) | 4.24446393 |
| 22 | skeletal muscle fiber development (GO:0048741) | 4.21602734 |
| 23 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 4.12292284 |
| 24 | regulation of actin filament-based movement (GO:1903115) | 4.11132630 |
| 25 | neuronal action potential propagation (GO:0019227) | 4.09647488 |
| 26 | response to muscle activity (GO:0014850) | 4.07653156 |
| 27 | glycogen catabolic process (GO:0005980) | 4.06521692 |
| 28 | response to activity (GO:0014823) | 4.01341886 |
| 29 | regulation of relaxation of muscle (GO:1901077) | 3.97420102 |
| 30 | striated muscle atrophy (GO:0014891) | 3.94038755 |
| 31 | myotube cell development (GO:0014904) | 3.91754070 |
| 32 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.89125192 |
| 33 | carnitine shuttle (GO:0006853) | 3.85942800 |
| 34 | glucan catabolic process (GO:0009251) | 3.78945549 |
| 35 | negative regulation of muscle hypertrophy (GO:0014741) | 3.76668470 |
| 36 | muscle contraction (GO:0006936) | 3.76665290 |
| 37 | actomyosin structure organization (GO:0031032) | 3.76403768 |
| 38 | muscle atrophy (GO:0014889) | 3.76395131 |
| 39 | regulation of striated muscle contraction (GO:0006942) | 3.75151300 |
| 40 | cardiac myofibril assembly (GO:0055003) | 3.74231546 |
| 41 | cardiac muscle contraction (GO:0060048) | 3.63370488 |
| 42 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.62361668 |
| 43 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.62361668 |
| 44 | striated muscle adaptation (GO:0014888) | 3.59411696 |
| 45 | muscle hypertrophy (GO:0014896) | 3.58593490 |
| 46 | ADP metabolic process (GO:0046031) | 3.58018870 |
| 47 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.57619145 |
| 48 | ubiquinone biosynthetic process (GO:0006744) | 3.57436773 |
| 49 | axon ensheathment in central nervous system (GO:0032291) | 3.57199958 |
| 50 | central nervous system myelination (GO:0022010) | 3.57199958 |
| 51 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.57029739 |
| 52 | myotube differentiation (GO:0014902) | 3.56157283 |
| 53 | regulation of myoblast differentiation (GO:0045661) | 3.51092772 |
| 54 | glycogen metabolic process (GO:0005977) | 3.49556664 |
| 55 | muscle cell fate commitment (GO:0042693) | 3.48459793 |
| 56 | AMP metabolic process (GO:0046033) | 3.47696134 |
| 57 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.45843854 |
| 58 | cellular polysaccharide catabolic process (GO:0044247) | 3.44091108 |
| 59 | muscle system process (GO:0003012) | 3.43194267 |
| 60 | glucan metabolic process (GO:0044042) | 3.41807716 |
| 61 | cellular glucan metabolic process (GO:0006073) | 3.41807716 |
| 62 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.39983154 |
| 63 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.36531639 |
| 64 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.33581428 |
| 65 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.33057197 |
| 66 | negative regulation of muscle contraction (GO:0045932) | 3.32759749 |
| 67 | relaxation of muscle (GO:0090075) | 3.32195749 |
| 68 | cellular response to epinephrine stimulus (GO:0071872) | 3.32191294 |
| 69 | polysaccharide catabolic process (GO:0000272) | 3.31375160 |
| 70 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.26875425 |
| 71 | response to epinephrine (GO:0071871) | 3.26384017 |
| 72 | 2-oxoglutarate metabolic process (GO:0006103) | 3.25695737 |
| 73 | muscle fiber development (GO:0048747) | 3.20431209 |
| 74 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.19054241 |
| 75 | otic vesicle formation (GO:0030916) | 3.15589639 |
| 76 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.15333666 |
| 77 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.15333666 |
| 78 | negative regulation of skeletal muscle tissue development (GO:0048642) | 3.13831020 |
| 79 | positive regulation of myoblast differentiation (GO:0045663) | 3.13167645 |
| 80 | fatty acid transmembrane transport (GO:1902001) | 3.12596148 |
| 81 | fructose metabolic process (GO:0006000) | 3.12559476 |
| 82 | regulation of membrane repolarization (GO:0060306) | 3.11517159 |
| 83 | ubiquinone metabolic process (GO:0006743) | 3.11250413 |
| 84 | adult heart development (GO:0007512) | 3.08202292 |
| 85 | muscle structure development (GO:0061061) | 3.07034951 |
| 86 | regulation of skeletal muscle fiber development (GO:0048742) | 3.06981725 |
| 87 | striated muscle tissue development (GO:0014706) | 3.04384370 |
| 88 | positive regulation of cation channel activity (GO:2001259) | 3.03287686 |
| 89 | myoblast fusion (GO:0007520) | 3.02950714 |
| 90 | quinone biosynthetic process (GO:1901663) | 3.02918445 |
| 91 | calcium ion import (GO:0070509) | 3.02357797 |
| 92 | regulation of sequestering of triglyceride (GO:0010889) | 3.01917782 |
| 93 | muscle organ development (GO:0007517) | 3.01484532 |
| 94 | muscle adaptation (GO:0043500) | 3.00685616 |
| 95 | muscle cell development (GO:0055001) | 2.98474291 |
| 96 | negative regulation of Rho protein signal transduction (GO:0035024) | 2.98184741 |
| 97 | carnitine transport (GO:0015879) | 2.97848125 |
| 98 | amino-acid betaine transport (GO:0015838) | 2.97848125 |
| 99 | regulation of muscle system process (GO:0090257) | 2.97518399 |
| 100 | regulation of sarcomere organization (GO:0060297) | 2.96725651 |
| 101 | neuromuscular synaptic transmission (GO:0007274) | 2.96065384 |
| 102 | muscle organ morphogenesis (GO:0048644) | 2.95741728 |
| 103 | response to caffeine (GO:0031000) | 2.94693414 |
| 104 | glucan biosynthetic process (GO:0009250) | 2.93410322 |
| 105 | glycogen biosynthetic process (GO:0005978) | 2.93410322 |
| 106 | cardiac muscle cell development (GO:0055013) | 2.88811864 |
| 107 | cardiac muscle tissue morphogenesis (GO:0055008) | 2.85982282 |
| 108 | import into cell (GO:0098657) | 2.84631275 |
| 109 | carnitine transmembrane transport (GO:1902603) | 2.82477361 |
| 110 | regulation of cofactor metabolic process (GO:0051193) | 2.81735329 |
| 111 | regulation of coenzyme metabolic process (GO:0051196) | 2.81735329 |
| 112 | muscle tissue morphogenesis (GO:0060415) | 2.81178399 |
| 113 | striated muscle hypertrophy (GO:0014897) | 2.79881307 |
| 114 | negative regulation of cardiac muscle hypertrophy (GO:0010614) | 2.78567168 |
| 115 | skeletal muscle tissue regeneration (GO:0043403) | 2.73212430 |
| 116 | respiratory electron transport chain (GO:0022904) | 2.71980459 |
| 117 | muscle cell cellular homeostasis (GO:0046716) | 2.69792342 |
| 118 | membrane tubulation (GO:0097320) | 2.69735556 |
| 119 | cardiac cell development (GO:0055006) | 2.68130987 |
| 120 | cardiac muscle hypertrophy (GO:0003300) | 2.67213602 |
| 121 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.66747613 |
| 122 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.65115610 |
| 123 | regulation of muscle contraction (GO:0006937) | 2.64968497 |
| 124 | ventricular cardiac muscle cell action potential (GO:0086005) | 2.64620685 |
| 125 | striated muscle cell development (GO:0055002) | 2.64288241 |
| 126 | electron transport chain (GO:0022900) | 2.62217784 |
| 127 | regulation of skeletal muscle cell differentiation (GO:2001014) | 2.61538838 |
| 128 | membrane depolarization during action potential (GO:0086010) | 2.61119294 |
| 129 | cytidine metabolic process (GO:0046087) | 2.59982412 |
| 130 | cytidine catabolic process (GO:0006216) | 2.59982412 |
| 131 | cytidine deamination (GO:0009972) | 2.59982412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.26866455 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.47338711 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.93431126 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.43015597 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.36560807 |
| 6 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.36001316 |
| 7 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.35013712 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.25125156 |
| 9 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.22636485 |
| 10 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.16681350 |
| 11 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.13357237 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.11557068 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.11557068 |
| 14 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.01661930 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.00247345 |
| 16 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.96571920 |
| 17 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.95945422 |
| 18 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.91917605 |
| 19 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.91771640 |
| 20 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.90908960 |
| 21 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.90746323 |
| 22 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.90343712 |
| 23 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.87611684 |
| 24 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.84684413 |
| 25 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.73730628 |
| 26 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.70248889 |
| 27 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69889765 |
| 28 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.69757209 |
| 29 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.68870956 |
| 30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.66202638 |
| 31 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.61238257 |
| 32 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.58936894 |
| 33 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.57194232 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.55094662 |
| 35 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.54675129 |
| 36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.51127269 |
| 37 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.50885362 |
| 38 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.49453793 |
| 39 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.46972424 |
| 40 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.45779996 |
| 41 | * VDR_22108803_ChIP-Seq_LS180_Human | 1.43316612 |
| 42 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.41180084 |
| 43 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.41180084 |
| 44 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.40828013 |
| 45 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.39586978 |
| 46 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.39116210 |
| 47 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.39063721 |
| 48 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.38040532 |
| 49 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.37626997 |
| 50 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.36974621 |
| 51 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.34764924 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32043424 |
| 53 | P300_19829295_ChIP-Seq_ESCs_Human | 1.30572761 |
| 54 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.28219803 |
| 55 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.26963468 |
| 56 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.25643011 |
| 57 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.24757465 |
| 58 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.22397492 |
| 59 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.19879493 |
| 60 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.19698335 |
| 61 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.19237040 |
| 62 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.18689241 |
| 63 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.17571449 |
| 64 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.17498708 |
| 65 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.17397706 |
| 66 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.16939964 |
| 67 | GATA1_22025678_ChIP-Seq_K562_Human | 1.16387906 |
| 68 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.14574404 |
| 69 | FUS_26573619_Chip-Seq_HEK293_Human | 1.12960876 |
| 70 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.12538370 |
| 71 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11185715 |
| 72 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.11178885 |
| 73 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.09847364 |
| 74 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.09555902 |
| 75 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.09543445 |
| 76 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.09186877 |
| 77 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.09080846 |
| 78 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09012490 |
| 79 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.08493940 |
| 80 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.08478706 |
| 81 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07702849 |
| 82 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.05741975 |
| 83 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05406994 |
| 84 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.03896225 |
| 85 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.03705062 |
| 86 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.03705062 |
| 87 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.03691046 |
| 88 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.03439388 |
| 89 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.02571993 |
| 90 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.02336035 |
| 91 | TP53_16413492_ChIP-PET_HCT116_Human | 1.02140776 |
| 92 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.01875388 |
| 93 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.01866449 |
| 94 | STAT3_23295773_ChIP-Seq_U87_Human | 1.01813271 |
| 95 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.01535228 |
| 96 | * TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.01343588 |
| 97 | * TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.01343588 |
| 98 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.01119229 |
| 99 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.00410316 |
| 100 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.00375499 |
| 101 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.99390552 |
| 102 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99387648 |
| 103 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.99294283 |
| 104 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.99294283 |
| 105 | AR_25329375_ChIP-Seq_VCAP_Human | 0.98558062 |
| 106 | RXR_22108803_ChIP-Seq_LS180_Human | 0.98163135 |
| 107 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.97862500 |
| 108 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.96880302 |
| 109 | * CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.96781888 |
| 110 | REST_21632747_ChIP-Seq_MESCs_Mouse | 0.96426602 |
| 111 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.95438303 |
| 112 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.95131931 |
| 113 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.95115210 |
| 114 | TCF4_23295773_ChIP-Seq_U87_Human | 0.95009846 |
| 115 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.94686327 |
| 116 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.94513468 |
| 117 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94513468 |
| 118 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.94512085 |
| 119 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.93675160 |
| 120 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.92719796 |
| 121 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.92510630 |
| 122 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.92005886 |
| 123 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91940208 |
| 124 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.91139953 |
| 125 | TBL1_22424771_ChIP-Seq_293T_Human | 0.90531409 |
| 126 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.89502069 |
| 127 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.88895019 |
| 128 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.86643738 |
| 129 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.86535616 |
| 130 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85396916 |
| 131 | CJUN_26792858_Chip-Seq_BT549_Human | 0.85170817 |
| 132 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.85088451 |
| 133 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.84790444 |
| 134 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.83999917 |
| 135 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.83511304 |
| 136 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.82538128 |
| 137 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.81293630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004145_abnormal_muscle_electrophysio | 6.14931546 |
| 2 | MP0003646_muscle_fatigue | 5.38511000 |
| 3 | MP0000751_myopathy | 5.15312544 |
| 4 | MP0000749_muscle_degeneration | 4.89700240 |
| 5 | MP0002837_dystrophic_cardiac_calcinosis | 4.33578783 |
| 6 | MP0004036_abnormal_muscle_relaxation | 3.58569563 |
| 7 | MP0002106_abnormal_muscle_physiology | 3.34062192 |
| 8 | MP0000747_muscle_weakness | 3.33480778 |
| 9 | MP0000759_abnormal_skeletal_muscle | 2.91077192 |
| 10 | MP0005369_muscle_phenotype | 2.82731679 |
| 11 | MP0005620_abnormal_muscle_contractility | 2.79216636 |
| 12 | MP0004087_abnormal_muscle_fiber | 2.68243654 |
| 13 | MP0000750_abnormal_muscle_regeneration | 2.64325383 |
| 14 | MP0004215_abnormal_myocardial_fiber | 2.48517536 |
| 15 | MP0004130_abnormal_muscle_cell | 2.44833080 |
| 16 | MP0002269_muscular_atrophy | 2.43012547 |
| 17 | MP0004084_abnormal_cardiac_muscle | 2.23659326 |
| 18 | MP0005330_cardiomyopathy | 2.17720684 |
| 19 | MP0003950_abnormal_plasma_membrane | 2.04833066 |
| 20 | MP0004270_analgesia | 1.79036700 |
| 21 | MP0002332_abnormal_exercise_endurance | 1.78930836 |
| 22 | MP0004484_altered_response_of | 1.76412287 |
| 23 | MP0004233_abnormal_muscle_weight | 1.68799141 |
| 24 | MP0003137_abnormal_impulse_conducting | 1.67970484 |
| 25 | MP0002972_abnormal_cardiac_muscle | 1.65638634 |
| 26 | MP0002108_abnormal_muscle_morphology | 1.58576263 |
| 27 | MP0003880_abnormal_central_pattern | 1.55998208 |
| 28 | MP0000013_abnormal_adipose_tissue | 1.53385949 |
| 29 | MP0003806_abnormal_nucleotide_metabolis | 1.52480089 |
| 30 | MP0003136_yellow_coat_color | 1.48549297 |
| 31 | MP0002102_abnormal_ear_morphology | 1.46943693 |
| 32 | MP0004185_abnormal_adipocyte_glucose | 1.30593497 |
| 33 | MP0005670_abnormal_white_adipose | 1.28634764 |
| 34 | MP0000733_abnormal_muscle_development | 1.26008920 |
| 35 | MP0005666_abnormal_adipose_tissue | 1.25212443 |
| 36 | MP0004142_abnormal_muscle_tone | 1.20682541 |
| 37 | MP0006036_abnormal_mitochondrial_physio | 1.20233260 |
| 38 | MP0010630_abnormal_cardiac_muscle | 1.16576794 |
| 39 | MP0005409_darkened_coat_color | 1.15543580 |
| 40 | MP0008775_abnormal_heart_ventricle | 1.14773823 |
| 41 | MP0001486_abnormal_startle_reflex | 1.14417963 |
| 42 | MP0001544_abnormal_cardiovascular_syste | 1.09958884 |
| 43 | MP0005385_cardiovascular_system_phenoty | 1.09958884 |
| 44 | MP0004085_abnormal_heartbeat | 1.09345743 |
| 45 | MP0000920_abnormal_myelination | 1.07614508 |
| 46 | MP0002234_abnormal_pharynx_morphology | 1.07228910 |
| 47 | MP0009250_abnormal_appendicular_skeleto | 1.07204869 |
| 48 | MP0004147_increased_porphyrin_level | 1.02319257 |
| 49 | MP0002822_catalepsy | 1.00614915 |
| 50 | MP0002971_abnormal_brown_adipose | 0.99344378 |
| 51 | MP0004742_abnormal_vestibular_system | 0.98066223 |
| 52 | MP0006138_congestive_heart_failure | 0.96632523 |
| 53 | MP0002272_abnormal_nervous_system | 0.96434509 |
| 54 | MP0001440_abnormal_grooming_behavior | 0.94468311 |
| 55 | MP0004043_abnormal_pH_regulation | 0.92853300 |
| 56 | MP0009046_muscle_twitch | 0.90808426 |
| 57 | MP0002067_abnormal_sensory_capabilities | 0.88561027 |
| 58 | MP0009780_abnormal_chondrocyte_physiolo | 0.88546691 |
| 59 | MP0002249_abnormal_larynx_morphology | 0.88198484 |
| 60 | MP0005451_abnormal_body_composition | 0.86495375 |
| 61 | MP0002127_abnormal_cardiovascular_syste | 0.85788738 |
| 62 | MP0005423_abnormal_somatic_nervous | 0.85094526 |
| 63 | MP0003045_fibrosis | 0.84288011 |
| 64 | MP0009745_abnormal_behavioral_response | 0.83451676 |
| 65 | MP0000762_abnormal_tongue_morphology | 0.82053941 |
| 66 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81749681 |
| 67 | MP0008569_lethality_at_weaning | 0.80813068 |
| 68 | MP0003828_pulmonary_edema | 0.80440412 |
| 69 | MP0000566_synostosis | 0.79034729 |
| 70 | MP0005375_adipose_tissue_phenotype | 0.79002560 |
| 71 | MP0004381_abnormal_hair_follicle | 0.77447506 |
| 72 | MP0004859_abnormal_synaptic_plasticity | 0.77436612 |
| 73 | MP0001661_extended_life_span | 0.75564307 |
| 74 | MP0003635_abnormal_synaptic_transmissio | 0.75178793 |
| 75 | MP0001188_hyperpigmentation | 0.74808807 |
| 76 | MP0003656_abnormal_erythrocyte_physiolo | 0.72739249 |
| 77 | MP0002734_abnormal_mechanical_nocicepti | 0.72151458 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.71767322 |
| 79 | MP0002064_seizures | 0.71543436 |
| 80 | MP0003879_abnormal_hair_cell | 0.69266433 |
| 81 | MP0005171_absent_coat_pigmentation | 0.69175635 |
| 82 | MP0004134_abnormal_chest_morphology | 0.68745179 |
| 83 | MP0005645_abnormal_hypothalamus_physiol | 0.68420897 |
| 84 | MP0005167_abnormal_blood-brain_barrier | 0.68258514 |
| 85 | MP0000383_abnormal_hair_follicle | 0.67929416 |
| 86 | MP0004510_myositis | 0.67882968 |
| 87 | MP0006072_abnormal_retinal_apoptosis | 0.67409314 |
| 88 | MP0001485_abnormal_pinna_reflex | 0.67362530 |
| 89 | MP0000049_abnormal_middle_ear | 0.66919595 |
| 90 | MP0006276_abnormal_autonomic_nervous | 0.64562519 |
| 91 | MP0001529_abnormal_vocalization | 0.64324363 |
| 92 | MP0003938_abnormal_ear_development | 0.64117022 |
| 93 | MP0000372_irregular_coat_pigmentation | 0.64047560 |
| 94 | MP0000230_abnormal_systemic_arterial | 0.62176730 |
| 95 | MP0001299_abnormal_eye_distance/ | 0.62093557 |
| 96 | MP0005551_abnormal_eye_electrophysiolog | 0.61356074 |
| 97 | MP0001727_abnormal_embryo_implantation | 0.61211064 |
| 98 | MP0001905_abnormal_dopamine_level | 0.60964763 |
| 99 | MP0002066_abnormal_motor_capabilities/c | 0.60826580 |
| 100 | MP0000462_abnormal_digestive_system | 0.60022010 |
| 101 | MP0002752_abnormal_somatic_nervous | 0.57422465 |
| 102 | MP0000026_abnormal_inner_ear | 0.56823354 |
| 103 | MP0002876_abnormal_thyroid_physiology | 0.56671907 |
| 104 | MP0006292_abnormal_olfactory_placode | 0.54528294 |
| 105 | MP0005165_increased_susceptibility_to | 0.54490938 |
| 106 | MP0005266_abnormal_metabolism | 0.53749886 |
| 107 | MP0000778_abnormal_nervous_system | 0.53456659 |
| 108 | MP0002229_neurodegeneration | 0.52774376 |
| 109 | MP0002735_abnormal_chemical_nociception | 0.52622790 |
| 110 | MP0000266_abnormal_heart_morphology | 0.52614314 |
| 111 | MP0003690_abnormal_glial_cell | 0.50030157 |
| 112 | MP0001963_abnormal_hearing_physiology | 0.48595120 |
| 113 | MP0002882_abnormal_neuron_morphology | 0.48287078 |
| 114 | MP0005376_homeostasis/metabolism_phenot | 0.48205955 |
| 115 | MP0005386_behavior/neurological_phenoty | 0.45943118 |
| 116 | MP0004924_abnormal_behavior | 0.45943118 |
| 117 | MP0001984_abnormal_olfaction | 0.45074173 |
| 118 | MP0002078_abnormal_glucose_homeostasis | 0.45032729 |
| 119 | MP0001501_abnormal_sleep_pattern | 0.44314733 |
| 120 | MP0000003_abnormal_adipose_tissue | 0.42900053 |
| 121 | MP0001986_abnormal_taste_sensitivity | 0.39768068 |
| 122 | MP0002277_abnormal_respiratory_mucosa | 0.39482022 |
| 123 | MP0005083_abnormal_biliary_tract | 0.37187306 |
| 124 | MP0009697_abnormal_copulation | 0.36671754 |
| 125 | MP0005535_abnormal_body_temperature | 0.36619749 |
| 126 | MP0003011_delayed_dark_adaptation | 0.34133271 |
| 127 | MP0002114_abnormal_axial_skeleton | 0.33662539 |
| 128 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.33346106 |
| 129 | MP0002128_abnormal_blood_circulation | 0.32084611 |
| 130 | MP0005452_abnormal_adipose_tissue | 0.31028913 |
| 131 | MP0003638_abnormal_response/metabolism_ | 0.30792285 |
| 132 | MP0006035_abnormal_mitochondrial_morpho | 0.30588273 |
| 133 | MP0005187_abnormal_penis_morphology | 0.30129096 |
| 134 | MP0003959_abnormal_lean_body | 0.29192026 |
| 135 | MP0008770_decreased_survivor_rate | 0.28147321 |
| 136 | MP0005319_abnormal_enzyme/_coenzyme | 0.27686859 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 8.05464949 |
| 2 | Muscle hypertrophy of the lower extremities (HP:0008968) | 7.62444075 |
| 3 | Muscle fiber inclusion bodies (HP:0100299) | 7.41101139 |
| 4 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 7.14292934 |
| 5 | Exercise-induced muscle cramps (HP:0003710) | 7.06143360 |
| 6 | Calf muscle hypertrophy (HP:0008981) | 6.90093551 |
| 7 | Nemaline bodies (HP:0003798) | 6.52665342 |
| 8 | Muscle fiber splitting (HP:0003555) | 5.61330697 |
| 9 | Type 1 muscle fiber predominance (HP:0003803) | 5.23461236 |
| 10 | Distal arthrogryposis (HP:0005684) | 5.18863094 |
| 11 | Difficulty running (HP:0009046) | 5.15317731 |
| 12 | Round ear (HP:0100830) | 4.95575355 |
| 13 | Abnormality of the calf musculature (HP:0001430) | 4.84964347 |
| 14 | Hyporeflexia of lower limbs (HP:0002600) | 4.84347983 |
| 15 | Myopathic facies (HP:0002058) | 4.55234793 |
| 16 | Myoglobinuria (HP:0002913) | 4.54682746 |
| 17 | EMG: myopathic abnormalities (HP:0003458) | 4.43912460 |
| 18 | Muscle stiffness (HP:0003552) | 4.29116436 |
| 19 | Sudden death (HP:0001699) | 4.16291109 |
| 20 | Myotonia (HP:0002486) | 4.00122040 |
| 21 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.97757622 |
| 22 | Ulnar deviation of the wrist (HP:0003049) | 3.79168318 |
| 23 | Absent phalangeal crease (HP:0006109) | 3.69613255 |
| 24 | Subaortic stenosis (HP:0001682) | 3.68569053 |
| 25 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.68569053 |
| 26 | Hyperkalemia (HP:0002153) | 3.65003668 |
| 27 | Rhabdomyolysis (HP:0003201) | 3.63400000 |
| 28 | Increased connective tissue (HP:0009025) | 3.63263039 |
| 29 | Calcaneovalgus deformity (HP:0001848) | 3.53197910 |
| 30 | Ventricular tachycardia (HP:0004756) | 3.20643261 |
| 31 | Deformed tarsal bones (HP:0008119) | 3.20538480 |
| 32 | Abnormal finger flexion creases (HP:0006143) | 3.15695355 |
| 33 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.01437130 |
| 34 | Neck muscle weakness (HP:0000467) | 2.95086793 |
| 35 | Increased variability in muscle fiber diameter (HP:0003557) | 2.90316164 |
| 36 | Malignant hyperthermia (HP:0002047) | 2.73289648 |
| 37 | Hypoplastic ischia (HP:0003175) | 2.70087315 |
| 38 | Rimmed vacuoles (HP:0003805) | 2.69529877 |
| 39 | Difficulty climbing stairs (HP:0003551) | 2.65714938 |
| 40 | Atrial fibrillation (HP:0005110) | 2.61710039 |
| 41 | Type 2 muscle fiber atrophy (HP:0003554) | 2.58701048 |
| 42 | Areflexia of lower limbs (HP:0002522) | 2.55905380 |
| 43 | Distal lower limb muscle weakness (HP:0009053) | 2.47964987 |
| 44 | Nonprogressive disorder (HP:0003680) | 2.43080054 |
| 45 | Abnormality of the neuromuscular junction (HP:0003398) | 2.40881958 |
| 46 | Fatigable weakness (HP:0003473) | 2.40881958 |
| 47 | Primary atrial arrhythmia (HP:0001692) | 2.40461873 |
| 48 | Distal lower limb amyotrophy (HP:0008944) | 2.39242728 |
| 49 | Limb-girdle muscle atrophy (HP:0003797) | 2.36564845 |
| 50 | Abnormality of the ischium (HP:0003174) | 2.35884183 |
| 51 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.34547363 |
| 52 | Asymmetric septal hypertrophy (HP:0001670) | 2.33942378 |
| 53 | Spinal rigidity (HP:0003306) | 2.33670791 |
| 54 | Gowers sign (HP:0003391) | 2.31379966 |
| 55 | Lipoatrophy (HP:0100578) | 2.28542026 |
| 56 | Muscle fiber atrophy (HP:0100295) | 2.25573934 |
| 57 | Supraventricular tachycardia (HP:0004755) | 2.24604591 |
| 58 | Muscular dystrophy (HP:0003560) | 2.23281644 |
| 59 | Paralysis (HP:0003470) | 2.20227599 |
| 60 | Supraventricular arrhythmia (HP:0005115) | 2.17226486 |
| 61 | Prolonged QT interval (HP:0001657) | 2.15325278 |
| 62 | Dilated cardiomyopathy (HP:0001644) | 2.12979553 |
| 63 | Syncope (HP:0001279) | 2.10980468 |
| 64 | Waddling gait (HP:0002515) | 2.09612789 |
| 65 | Right ventricular cardiomyopathy (HP:0011663) | 2.04630783 |
| 66 | Frequent falls (HP:0002359) | 1.96436501 |
| 67 | Weak cry (HP:0001612) | 1.96041797 |
| 68 | Bulbar palsy (HP:0001283) | 1.95094518 |
| 69 | Lower limb amyotrophy (HP:0007210) | 1.92183798 |
| 70 | Scapular winging (HP:0003691) | 1.91991922 |
| 71 | Generalized muscle weakness (HP:0003324) | 1.91038144 |
| 72 | Focal motor seizures (HP:0011153) | 1.90515022 |
| 73 | Abnormality of potassium homeostasis (HP:0011042) | 1.88823045 |
| 74 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.88451331 |
| 75 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.88451331 |
| 76 | Acute necrotizing encephalopathy (HP:0006965) | 1.88269702 |
| 77 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.85632401 |
| 78 | Fibular aplasia (HP:0002990) | 1.85175227 |
| 79 | Shoulder girdle muscle weakness (HP:0003547) | 1.84999866 |
| 80 | EMG: neuropathic changes (HP:0003445) | 1.83758878 |
| 81 | Left ventricular hypertrophy (HP:0001712) | 1.82240650 |
| 82 | Abnormality of the calcaneus (HP:0008364) | 1.80740867 |
| 83 | Facial diplegia (HP:0001349) | 1.79703074 |
| 84 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.78405671 |
| 85 | Long clavicles (HP:0000890) | 1.77036710 |
| 86 | Broad-based gait (HP:0002136) | 1.76976311 |
| 87 | Oligomenorrhea (HP:0000876) | 1.73275498 |
| 88 | Ventricular arrhythmia (HP:0004308) | 1.73170124 |
| 89 | Foot dorsiflexor weakness (HP:0009027) | 1.72920255 |
| 90 | Fetal akinesia sequence (HP:0001989) | 1.71188905 |
| 91 | Abnormal atrioventricular conduction (HP:0005150) | 1.70965369 |
| 92 | Proximal amyotrophy (HP:0007126) | 1.70750663 |
| 93 | Slender build (HP:0001533) | 1.70393055 |
| 94 | Abnormality of the parathyroid morphology (HP:0011766) | 1.70001383 |
| 95 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.69804552 |
| 96 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.69804552 |
| 97 | Bundle branch block (HP:0011710) | 1.69365707 |
| 98 | Exercise intolerance (HP:0003546) | 1.69069235 |
| 99 | Pelvic girdle muscle weakness (HP:0003749) | 1.68857401 |
| 100 | Double outlet right ventricle (HP:0001719) | 1.68010053 |
| 101 | Congenital malformation of the right heart (HP:0011723) | 1.68010053 |
| 102 | Limb-girdle muscle weakness (HP:0003325) | 1.66298481 |
| 103 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.65789264 |
| 104 | Aplasia cutis congenita (HP:0001057) | 1.64940004 |
| 105 | Bell-shaped thorax (HP:0001591) | 1.63285044 |
| 106 | Nasal speech (HP:0001611) | 1.63252218 |
| 107 | Palpitations (HP:0001962) | 1.62478733 |
| 108 | Abnormality of the foot musculature (HP:0001436) | 1.62076997 |
| 109 | Clumsiness (HP:0002312) | 1.61601324 |
| 110 | Heart block (HP:0012722) | 1.61396205 |
| 111 | Hip contracture (HP:0003273) | 1.60727593 |
| 112 | Limited hip movement (HP:0008800) | 1.60412652 |
| 113 | Steppage gait (HP:0003376) | 1.59574380 |
| 114 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.59218997 |
| 115 | Popliteal pterygium (HP:0009756) | 1.59209448 |
| 116 | Ulnar deviation of finger (HP:0009465) | 1.46185948 |
| 117 | Metatarsus adductus (HP:0001840) | 1.42888559 |
| 118 | Easy fatigability (HP:0003388) | 1.41131820 |
| 119 | Type II lissencephaly (HP:0007260) | 1.40831767 |
| 120 | Progressive muscle weakness (HP:0003323) | 1.38938708 |
| 121 | Difficulty walking (HP:0002355) | 1.34789836 |
| 122 | Hypokalemia (HP:0002900) | 1.30612538 |
| 123 | Ulnar deviation of the hand or of fingers of the hand (HP:0001193) | 1.28705490 |
| 124 | Poor eye contact (HP:0000817) | 1.27571690 |
| 125 | Neonatal hypotonia (HP:0001319) | 1.24593508 |
| 126 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.23004650 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 5.89929703 |
| 2 | PHKG1 | 5.21379674 |
| 3 | PHKG2 | 5.21379674 |
| 4 | TTN | 4.88004030 |
| 5 | NME1 | 2.93459648 |
| 6 | PIK3CA | 2.63850905 |
| 7 | CASK | 2.61657008 |
| 8 | BLK | 2.47328571 |
| 9 | MUSK | 2.34719106 |
| 10 | DMPK | 2.30356415 |
| 11 | TNIK | 2.18587379 |
| 12 | PIK3CG | 2.16927175 |
| 13 | STK39 | 2.11949039 |
| 14 | PKN1 | 1.87531320 |
| 15 | INSRR | 1.80679901 |
| 16 | PINK1 | 1.76041184 |
| 17 | MAP3K7 | 1.61496956 |
| 18 | PDK3 | 1.44530539 |
| 19 | PDK4 | 1.44530539 |
| 20 | OXSR1 | 1.35858015 |
| 21 | MAPK12 | 1.35775356 |
| 22 | EPHB1 | 1.32891569 |
| 23 | MAP2K3 | 1.25617420 |
| 24 | FRK | 1.23292899 |
| 25 | PRKAA2 | 1.22617966 |
| 26 | GRK7 | 1.21565607 |
| 27 | MKNK2 | 1.20889821 |
| 28 | MAPKAPK3 | 1.18195535 |
| 29 | GRK1 | 1.14992591 |
| 30 | MARK3 | 1.14356593 |
| 31 | CCNB1 | 1.09875094 |
| 32 | MAP2K4 | 1.09497580 |
| 33 | CAMK2D | 1.06476139 |
| 34 | PDK2 | 1.04899093 |
| 35 | PNCK | 1.04294435 |
| 36 | NTRK3 | 0.99704872 |
| 37 | FGR | 0.87184092 |
| 38 | DAPK2 | 0.85426843 |
| 39 | CAMK2G | 0.84093904 |
| 40 | CAMK2A | 0.83663916 |
| 41 | WNK1 | 0.82330411 |
| 42 | NEK6 | 0.82097655 |
| 43 | WNK4 | 0.81625096 |
| 44 | MAP4K2 | 0.81403136 |
| 45 | EPHA4 | 0.78755738 |
| 46 | CAMK4 | 0.76793424 |
| 47 | TRPM7 | 0.76272127 |
| 48 | TIE1 | 0.75034883 |
| 49 | ROCK2 | 0.74278994 |
| 50 | CAMK1G | 0.72814400 |
| 51 | PAK3 | 0.71464982 |
| 52 | MOS | 0.69420209 |
| 53 | PRKD1 | 0.68205454 |
| 54 | CAMK2B | 0.67868995 |
| 55 | EEF2K | 0.67205745 |
| 56 | PRKG1 | 0.66507501 |
| 57 | SGK2 | 0.65452043 |
| 58 | MAP2K6 | 0.64142357 |
| 59 | BCKDK | 0.62787150 |
| 60 | MAP3K6 | 0.61721725 |
| 61 | PAK6 | 0.61069371 |
| 62 | MAP3K1 | 0.60919443 |
| 63 | MYLK | 0.60766806 |
| 64 | MAPK13 | 0.60480391 |
| 65 | PRKCE | 0.59693341 |
| 66 | PRKAA1 | 0.58005147 |
| 67 | SGK1 | 0.57903642 |
| 68 | ZAK | 0.57520212 |
| 69 | LATS1 | 0.57416780 |
| 70 | MAP3K13 | 0.56513235 |
| 71 | PRKACA | 0.54588817 |
| 72 | STK16 | 0.53517710 |
| 73 | PRKACB | 0.51667140 |
| 74 | STK24 | 0.50681556 |
| 75 | RPS6KB1 | 0.48684813 |
| 76 | MAPK4 | 0.48117057 |
| 77 | TNK2 | 0.47439238 |
| 78 | ROCK1 | 0.47354567 |
| 79 | ERBB3 | 0.47045228 |
| 80 | IRAK1 | 0.47044122 |
| 81 | SGK3 | 0.46091072 |
| 82 | SGK223 | 0.45924581 |
| 83 | SGK494 | 0.45924581 |
| 84 | ADRBK2 | 0.44416022 |
| 85 | CDK3 | 0.43954896 |
| 86 | PRKCQ | 0.43801669 |
| 87 | MARK2 | 0.43748688 |
| 88 | CAMK1 | 0.42422948 |
| 89 | LIMK1 | 0.40951912 |
| 90 | MARK1 | 0.40805664 |
| 91 | EPHA3 | 0.40571272 |
| 92 | CDC42BPA | 0.40514663 |
| 93 | MAPKAPK5 | 0.39846790 |
| 94 | MAPK11 | 0.39147544 |
| 95 | FES | 0.38831397 |
| 96 | MAP2K1 | 0.37507995 |
| 97 | BMPR1B | 0.36929646 |
| 98 | FER | 0.35784166 |
| 99 | TGFBR1 | 0.33968356 |
| 100 | UHMK1 | 0.33722088 |
| 101 | NEK9 | 0.32919648 |
| 102 | BCR | 0.32472812 |
| 103 | LMTK2 | 0.32180234 |
| 104 | MKNK1 | 0.32070600 |
| 105 | TAOK3 | 0.31964250 |
| 106 | MAPK15 | 0.31396973 |
| 107 | PRPF4B | 0.31060217 |
| 108 | CDK19 | 0.31039078 |
| 109 | PRKG2 | 0.30714910 |
| 110 | IRAK2 | 0.30267612 |
| 111 | ICK | 0.29387628 |
| 112 | MAP3K4 | 0.28761254 |
| 113 | PDPK1 | 0.28742400 |
| 114 | STK38L | 0.28637483 |
| 115 | STK11 | 0.28275798 |
| 116 | DYRK1B | 0.27420045 |
| 117 | RPS6KA3 | 0.26259223 |
| 118 | AKT2 | 0.25976556 |
| 119 | MAPK7 | 0.25318118 |
| 120 | ADRBK1 | 0.24415614 |
| 121 | ACVR1B | 0.23181391 |
| 122 | TBK1 | 0.22773788 |
| 123 | PRKD2 | 0.22241323 |
| 124 | CSNK1D | 0.21433556 |
| 125 | ZAP70 | 0.21155066 |
| 126 | NLK | 0.21067359 |
| 127 | CLK1 | 0.20944038 |
| 128 | FYN | 0.20851193 |
| 129 | DDR2 | 0.20360106 |
| 130 | RPS6KA1 | 0.20246989 |
| 131 | PTK2B | 0.20241155 |
| 132 | CDK5 | 0.19838610 |
| 133 | EIF2AK2 | 0.19376593 |
| 134 | MAP2K7 | 0.18846299 |
| 135 | PDK1 | 0.18287376 |
| 136 | YES1 | 0.18170029 |
| 137 | WNK3 | 0.18021313 |
| 138 | PRKACG | 0.17992337 |
| 139 | RPS6KA6 | 0.14287531 |
| 140 | KIT | 0.10727114 |
| 141 | RPS6KA5 | 0.10594046 |
| 142 | SYK | 0.10321619 |
| 143 | NTRK2 | 0.08852427 |
| 144 | MAPK10 | 0.07808340 |
| 145 | MAPK3 | 0.07796353 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.84074326 |
| 2 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.69095510 |
| 3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.33848525 |
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 3.22330436 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.76035080 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.36276124 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.28228096 |
| 8 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 2.20902547 |
| 9 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.11071312 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.08820882 |
| 11 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.06125745 |
| 12 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.02107397 |
| 13 | * Calcium signaling pathway_Homo sapiens_hsa04020 | 1.90909463 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.89744781 |
| 15 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.85979293 |
| 16 | * Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.75234989 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.71486325 |
| 18 | Nicotine addiction_Homo sapiens_hsa05033 | 1.60300595 |
| 19 | Phototransduction_Homo sapiens_hsa04744 | 1.52840627 |
| 20 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.50526876 |
| 21 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.37991020 |
| 22 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.37788278 |
| 23 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.34541428 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.32645985 |
| 25 | Circadian rhythm_Homo sapiens_hsa04710 | 1.28944224 |
| 26 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.28276777 |
| 27 | Huntingtons disease_Homo sapiens_hsa05016 | 1.28100278 |
| 28 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.25756710 |
| 29 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.23570849 |
| 30 | Taste transduction_Homo sapiens_hsa04742 | 1.22346897 |
| 31 | Renin secretion_Homo sapiens_hsa04924 | 1.22096482 |
| 32 | GABAergic synapse_Homo sapiens_hsa04727 | 1.21410939 |
| 33 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.20745709 |
| 34 | Morphine addiction_Homo sapiens_hsa05032 | 1.20446664 |
| 35 | * cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.19714805 |
| 36 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.18981794 |
| 37 | * Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.18467954 |
| 38 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.18174543 |
| 39 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.16947934 |
| 40 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.16543839 |
| 41 | Axon guidance_Homo sapiens_hsa04360 | 1.12042245 |
| 42 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.11180012 |
| 43 | Circadian entrainment_Homo sapiens_hsa04713 | 1.10150210 |
| 44 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.08735286 |
| 45 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.04257722 |
| 46 | Tight junction_Homo sapiens_hsa04530 | 1.03759881 |
| 47 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.02467981 |
| 48 | Salivary secretion_Homo sapiens_hsa04970 | 1.01314356 |
| 49 | Long-term depression_Homo sapiens_hsa04730 | 0.97703853 |
| 50 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.96378475 |
| 51 | Insulin secretion_Homo sapiens_hsa04911 | 0.94036917 |
| 52 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.93744750 |
| 53 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.90806387 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.90587994 |
| 55 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.90576425 |
| 56 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.90271391 |
| 57 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.90154776 |
| 58 | * Gastric acid secretion_Homo sapiens_hsa04971 | 0.87997387 |
| 59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.85282356 |
| 60 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.85247935 |
| 61 | Viral myocarditis_Homo sapiens_hsa05416 | 0.83898382 |
| 62 | Insulin resistance_Homo sapiens_hsa04931 | 0.82629608 |
| 63 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.82380301 |
| 64 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.81725751 |
| 65 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.79184696 |
| 66 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.77060059 |
| 67 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.76332629 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.73888351 |
| 69 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.73267211 |
| 70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70721578 |
| 71 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.70359820 |
| 72 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.70036012 |
| 73 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.69810618 |
| 74 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.68976136 |
| 75 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.66417882 |
| 76 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.65714824 |
| 77 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.64940069 |
| 78 | Carbon metabolism_Homo sapiens_hsa01200 | 0.64370500 |
| 79 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.60294053 |
| 80 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.59846101 |
| 81 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58910680 |
| 82 | * Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.58330631 |
| 83 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55720495 |
| 84 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.54501113 |
| 85 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.53304318 |
| 86 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.53207649 |
| 87 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.52838848 |
| 88 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.52662667 |
| 89 | * Focal adhesion_Homo sapiens_hsa04510 | 0.52601198 |
| 90 | * Platelet activation_Homo sapiens_hsa04611 | 0.51641793 |
| 91 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.49501088 |
| 92 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.49199435 |
| 93 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.49002183 |
| 94 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.47960249 |
| 95 | Peroxisome_Homo sapiens_hsa04146 | 0.47718355 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46187883 |
| 97 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.45474629 |
| 98 | Olfactory transduction_Homo sapiens_hsa04740 | 0.44984763 |
| 99 | Long-term potentiation_Homo sapiens_hsa04720 | 0.43336766 |
| 100 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.42283524 |
| 101 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.40538645 |
| 102 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.40303068 |
| 103 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.39996464 |
| 104 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.39665171 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.39357055 |
| 106 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39288055 |
| 107 | Melanoma_Homo sapiens_hsa05218 | 0.37516698 |
| 108 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.36706901 |
| 109 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.36440453 |
| 110 | Purine metabolism_Homo sapiens_hsa00230 | 0.36278693 |
| 111 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.35096298 |
| 112 | Melanogenesis_Homo sapiens_hsa04916 | 0.33636009 |
| 113 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.30119797 |
| 114 | Lysine degradation_Homo sapiens_hsa00310 | 0.29645105 |
| 115 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.29106629 |
| 116 | ABC transporters_Homo sapiens_hsa02010 | 0.27993939 |
| 117 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.27946434 |
| 118 | Cocaine addiction_Homo sapiens_hsa05030 | 0.27869920 |
| 119 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.27799408 |
| 120 | Gap junction_Homo sapiens_hsa04540 | 0.24360550 |
| 121 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.23399507 |
| 122 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.23399027 |
| 123 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.21993815 |

