MYNN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.14646372
2nuclear pore organization (GO:0006999)4.06913821
3proteasome assembly (GO:0043248)4.00525674
4cullin deneddylation (GO:0010388)4.00413234
5regulation of mitotic spindle checkpoint (GO:1903504)3.80484513
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.80484513
7meiotic chromosome segregation (GO:0045132)3.76052929
8ribosome assembly (GO:0042255)3.66864988
9regulation of DNA endoreduplication (GO:0032875)3.60249020
10mitotic sister chromatid cohesion (GO:0007064)3.60146521
11replication fork processing (GO:0031297)3.50081802
12protein deneddylation (GO:0000338)3.47502160
13CENP-A containing nucleosome assembly (GO:0034080)3.47200421
14respiratory chain complex IV assembly (GO:0008535)3.44937776
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.42079407
16non-recombinational repair (GO:0000726)3.37009029
17double-strand break repair via nonhomologous end joining (GO:0006303)3.37009029
18metaphase plate congression (GO:0051310)3.34564864
19chromatin remodeling at centromere (GO:0031055)3.33961932
20kinetochore organization (GO:0051383)3.29350934
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26714053
22pore complex assembly (GO:0046931)3.26052472
23attachment of spindle microtubules to kinetochore (GO:0008608)3.25311168
24regulation of spindle organization (GO:0090224)3.21643357
25histone H2A acetylation (GO:0043968)3.20346032
26negative regulation of DNA recombination (GO:0045910)3.19252087
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16593839
28establishment of chromosome localization (GO:0051303)3.16050960
29response to pheromone (GO:0019236)3.15810815
30keratinocyte development (GO:0003334)3.15705382
31regulation of glucokinase activity (GO:0033131)3.14331067
32regulation of hexokinase activity (GO:1903299)3.14331067
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14179334
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14179334
35rRNA modification (GO:0000154)3.13808204
36intraciliary transport (GO:0042073)3.10259399
37response to X-ray (GO:0010165)3.10178889
38maturation of 5.8S rRNA (GO:0000460)3.09567447
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06904562
40DNA ligation (GO:0006266)3.04688591
41mitotic nuclear envelope disassembly (GO:0007077)3.01463663
42protein prenylation (GO:0018342)3.01081929
43prenylation (GO:0097354)3.01081929
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.00775832
45regulation of mitotic spindle organization (GO:0060236)2.99233150
46DNA replication-independent nucleosome assembly (GO:0006336)2.99082545
47DNA replication-independent nucleosome organization (GO:0034724)2.99082545
48rRNA methylation (GO:0031167)2.97499018
49mitotic metaphase plate congression (GO:0007080)2.94215264
50inositol phosphate catabolic process (GO:0071545)2.92529110
51double-strand break repair via homologous recombination (GO:0000724)2.92039895
52recombinational repair (GO:0000725)2.91906769
53somatic hypermutation of immunoglobulin genes (GO:0016446)2.89071215
54somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89071215
55mitotic chromosome condensation (GO:0007076)2.88498301
56histone mRNA metabolic process (GO:0008334)2.88123603
57regulation of meiosis I (GO:0060631)2.87684587
58protein-cofactor linkage (GO:0018065)2.85573166
59resolution of meiotic recombination intermediates (GO:0000712)2.84014343
60telomere maintenance via telomerase (GO:0007004)2.83901678
61DNA catabolic process, exonucleolytic (GO:0000738)2.83580417
62monoubiquitinated protein deubiquitination (GO:0035520)2.80989668
63pseudouridine synthesis (GO:0001522)2.80348205
64positive regulation of mRNA processing (GO:0050685)2.80259730
65DNA damage induced protein phosphorylation (GO:0006975)2.78880003
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.78813333
67nuclear envelope disassembly (GO:0051081)2.77820052
68membrane disassembly (GO:0030397)2.77820052
69synapsis (GO:0007129)2.76345159
70mitochondrial DNA replication (GO:0006264)2.76340853
71sister chromatid cohesion (GO:0007062)2.76267847
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76118192
73kinetochore assembly (GO:0051382)2.74500062
74purine nucleobase biosynthetic process (GO:0009113)2.74404544
75histone exchange (GO:0043486)2.72492123
76N-terminal protein amino acid acetylation (GO:0006474)2.71657400
77positive regulation of keratinocyte differentiation (GO:0045618)2.71095868
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.69699658
79mismatch repair (GO:0006298)2.68089131
80regulation of vitamin D biosynthetic process (GO:0060556)2.67541858
81tachykinin receptor signaling pathway (GO:0007217)2.66972224
82acrosome assembly (GO:0001675)2.66418039
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66293570
84sister chromatid segregation (GO:0000819)2.65801869
85cytochrome complex assembly (GO:0017004)2.65437961
86positive regulation of histone H3-K4 methylation (GO:0051571)2.65181537
87DNA replication initiation (GO:0006270)2.64160224
88spindle checkpoint (GO:0031577)2.64042941
89DNA integration (GO:0015074)2.62111017
90spindle assembly checkpoint (GO:0071173)2.61187555
91histone H2A monoubiquitination (GO:0035518)2.61168921
92regulation of helicase activity (GO:0051095)2.58926396
93nonmotile primary cilium assembly (GO:0035058)2.58330722
94definitive hemopoiesis (GO:0060216)2.57361118
95DNA replication-dependent nucleosome assembly (GO:0006335)2.57245671
96DNA replication-dependent nucleosome organization (GO:0034723)2.57245671
97regulation of histone H3-K9 methylation (GO:0051570)2.57213554
98neural tube formation (GO:0001841)2.56533988
99mitotic spindle assembly checkpoint (GO:0007094)2.55795108
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54224444
101nucleobase biosynthetic process (GO:0046112)2.53513131
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53120042
103negative regulation of sister chromatid segregation (GO:0033046)2.53120042
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.53120042
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53120042
106drinking behavior (GO:0042756)2.52878465
107positive regulation of mitochondrial fission (GO:0090141)2.52045094
108DNA synthesis involved in DNA repair (GO:0000731)2.51414663
109mitotic spindle checkpoint (GO:0071174)2.50869532
110positive regulation of DNA-dependent DNA replication (GO:2000105)2.50442989
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49905159
112mitotic sister chromatid segregation (GO:0000070)2.49653171
113regulation of nuclear cell cycle DNA replication (GO:0033262)2.49351131
114DNA replication checkpoint (GO:0000076)2.47622020
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47618049
116negative regulation of chromosome segregation (GO:0051985)2.47272892
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45258866
118protein K6-linked ubiquitination (GO:0085020)2.44472773
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43862328
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43862328
121isotype switching (GO:0045190)2.43862328
122chromosome segregation (GO:0007059)2.41946193
123regulation of sister chromatid segregation (GO:0033045)2.39942889
124regulation of mitotic sister chromatid separation (GO:0010965)2.39942889
125regulation of mitotic sister chromatid segregation (GO:0033047)2.39942889
126IMP biosynthetic process (GO:0006188)2.39563306
127regulation of centriole replication (GO:0046599)2.36108896
128DNA double-strand break processing (GO:0000729)2.35980375
129mitotic G2/M transition checkpoint (GO:0044818)2.34331569
130transcription initiation from RNA polymerase I promoter (GO:0006361)2.33889776
131intra-S DNA damage checkpoint (GO:0031573)2.31851451
132reciprocal meiotic recombination (GO:0007131)2.30544331
133reciprocal DNA recombination (GO:0035825)2.30544331
134somatic recombination of immunoglobulin gene segments (GO:0016447)2.28881863
135DNA-dependent DNA replication (GO:0006261)2.28771135
136telomere maintenance via recombination (GO:0000722)2.28081858
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.27948635
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.26956221
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.26956221
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.26956221
141mitotic recombination (GO:0006312)2.25531031
142telomere maintenance (GO:0000723)2.24800748
143telomere organization (GO:0032200)2.24720123
144fat-soluble vitamin catabolic process (GO:0042363)2.24297272
145vitamin catabolic process (GO:0009111)2.24297272
146termination of RNA polymerase I transcription (GO:0006363)2.22883132
147centriole replication (GO:0007099)2.21549820
148regulation of vitamin metabolic process (GO:0030656)2.21394569
149DNA topological change (GO:0006265)2.20555477
150fat-soluble vitamin biosynthetic process (GO:0042362)2.20217528
151negative regulation of histone methylation (GO:0031061)2.19650065
152regulation of chromosome segregation (GO:0051983)2.18711363
153regulation of fibroblast apoptotic process (GO:2000269)2.17979020
154ATP-dependent chromatin remodeling (GO:0043044)2.17791997
155regulation of DNA-dependent DNA replication (GO:0090329)2.16447861
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.16419187
157telomere maintenance via semi-conservative replication (GO:0032201)2.16269693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76431983
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48073617
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.42198804
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39115199
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.15566555
6* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10948194
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.85607674
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.84392167
9ZNF274_21170338_ChIP-Seq_K562_Hela2.64899319
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61432130
11IGF1R_20145208_ChIP-Seq_DFB_Human2.50630246
12ELK1_19687146_ChIP-ChIP_HELA_Human2.45977560
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39524868
14VDR_22108803_ChIP-Seq_LS180_Human2.36651767
15* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24770365
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21414290
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17745640
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.16237299
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.14637744
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10036881
21* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06814984
22GBX2_23144817_ChIP-Seq_PC3_Human2.05234449
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05054411
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99807240
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.96590829
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93433544
27VDR_23849224_ChIP-Seq_CD4+_Human1.92828165
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92036287
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.90928187
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.86381205
31P300_19829295_ChIP-Seq_ESCs_Human1.86345137
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83055645
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82707212
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82336124
35TAF15_26573619_Chip-Seq_HEK293_Human1.81826463
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81059243
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79677953
38AR_21909140_ChIP-Seq_LNCAP_Human1.78485715
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76304946
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75999200
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.74305908
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73341421
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72024324
44* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71952682
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71131907
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67823603
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.65236335
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62507658
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61479229
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60156121
51FOXP3_21729870_ChIP-Seq_TREG_Human1.54002018
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52986832
53EWS_26573619_Chip-Seq_HEK293_Human1.51083420
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46869567
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.43836247
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41912060
57* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41445582
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.40872011
59ER_23166858_ChIP-Seq_MCF-7_Human1.38619146
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37243145
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36744366
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36228911
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.36167725
64* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35428266
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33934843
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.33285875
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32756574
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31782262
69* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31596566
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31200775
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29208268
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26880456
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26476990
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26286553
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.26049575
76MYB_26560356_Chip-Seq_TH2_Human1.25950175
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25656676
78CBP_20019798_ChIP-Seq_JUKART_Human1.25430151
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25430151
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25205701
81SMAD4_21799915_ChIP-Seq_A2780_Human1.24882296
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24572925
83RUNX_20019798_ChIP-Seq_JUKART_Human1.24255943
84* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23750041
85* SRF_21415370_ChIP-Seq_HL-1_Mouse1.22320462
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21836796
87MYC_18940864_ChIP-ChIP_HL60_Human1.21421759
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21375241
89* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20721356
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19870498
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19732058
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17340737
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17229254
94SCL_19346495_ChIP-Seq_HPC-7_Human1.16905464
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.16391034
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.14412035
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14139616
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13503005
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13094599
100AR_25329375_ChIP-Seq_VCAP_Human1.12627538
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12544181
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.12377813
103STAT3_23295773_ChIP-Seq_U87_Human1.11237748
104FUS_26573619_Chip-Seq_HEK293_Human1.10407246
105* SPI1_23547873_ChIP-Seq_NB4_Human1.10335055
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10098917
107MYB_26560356_Chip-Seq_TH1_Human1.09864374
108SALL4_22934838_ChIP-ChIP_CD34+_Human1.09692565
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09370848
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08262518
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.07569250
112CIITA_25753668_ChIP-Seq_RAJI_Human1.07310520
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.07267047
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06953277
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06921598
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05162869
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04959230
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.04556750
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04447198
120* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03743412
121MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02844198
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02657661
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02307322
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01915319
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01105243
126* DCP1A_22483619_ChIP-Seq_HELA_Human1.00373341
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99892077
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.99782653
129TTF2_22483619_ChIP-Seq_HELA_Human0.99522267
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99460046
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99038179
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98877094
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98782822
134TCF4_22108803_ChIP-Seq_LS180_Human0.96999114
135IRF1_19129219_ChIP-ChIP_H3396_Human0.96888666
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.96743292
137TP53_22573176_ChIP-Seq_HFKS_Human0.96663022
138CDX2_22108803_ChIP-Seq_LS180_Human0.96533526
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96445255
140NANOG_19829295_ChIP-Seq_ESCs_Human0.96082904
141SOX2_19829295_ChIP-Seq_ESCs_Human0.96082904
142TCF4_23295773_ChIP-Seq_U87_Human0.95998099
143BCAT_22108803_ChIP-Seq_LS180_Human0.94414679
144P53_22387025_ChIP-Seq_ESCs_Mouse0.93693106
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.93016419
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92334045
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92232698
148KDM5A_27292631_Chip-Seq_BREAST_Human0.91898834
149* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91058451
150TFEB_21752829_ChIP-Seq_HELA_Human0.90472134
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89962526
152GABP_19822575_ChIP-Seq_HepG2_Human0.89534322
153HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88515117
154XRN2_22483619_ChIP-Seq_HELA_Human0.88292861
155* MYC_22102868_ChIP-Seq_BL_Human0.87048150
156POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86911605
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83544994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.33916844
2MP0010094_abnormal_chromosome_stability3.31918224
3MP0008007_abnormal_cellular_replicative3.28719172
4MP0008057_abnormal_DNA_replication3.19668121
5MP0008058_abnormal_DNA_repair2.91367123
6MP0003693_abnormal_embryo_hatching2.75554309
7MP0003077_abnormal_cell_cycle2.58057157
8MP0003111_abnormal_nucleus_morphology2.46924638
9MP0001529_abnormal_vocalization2.35833831
10MP0003763_abnormal_thymus_physiology2.19064184
11MP0006072_abnormal_retinal_apoptosis2.10917895
12MP0002102_abnormal_ear_morphology2.09696954
13MP0002736_abnormal_nociception_after2.08671873
14MP0001835_abnormal_antigen_presentation2.06916251
15MP0006054_spinal_hemorrhage2.05825943
16MP0002009_preneoplasia2.05156498
17MP0005671_abnormal_response_to1.95927571
18MP0006276_abnormal_autonomic_nervous1.95239830
19MP0000569_abnormal_digit_pigmentation1.94797905
20MP0009697_abnormal_copulation1.89622273
21MP0004957_abnormal_blastocyst_morpholog1.89358676
22MP0002837_dystrophic_cardiac_calcinosis1.81485440
23MP0004808_abnormal_hematopoietic_stem1.77955687
24MP0002277_abnormal_respiratory_mucosa1.76928109
25MP0004147_increased_porphyrin_level1.75791535
26MP0002751_abnormal_autonomic_nervous1.72595339
27MP0004215_abnormal_myocardial_fiber1.70478599
28MP0002938_white_spotting1.70236910
29MP0003880_abnormal_central_pattern1.68587468
30MP0000427_abnormal_hair_cycle1.66037919
31MP0008877_abnormal_DNA_methylation1.62544634
32MP0003724_increased_susceptibility_to1.59973332
33MP0000516_abnormal_urinary_system1.59342305
34MP0005367_renal/urinary_system_phenotyp1.59342305
35MP0010307_abnormal_tumor_latency1.58172157
36MP0006292_abnormal_olfactory_placode1.52802565
37MP0003195_calcinosis1.52465434
38MP0005253_abnormal_eye_physiology1.51978204
39MP0000372_irregular_coat_pigmentation1.48665659
40MP0002398_abnormal_bone_marrow1.47313602
41MP0008995_early_reproductive_senescence1.46955259
42MP0009780_abnormal_chondrocyte_physiolo1.46008756
43MP0000678_abnormal_parathyroid_gland1.44687166
44MP0001968_abnormal_touch/_nociception1.43570451
45MP0003656_abnormal_erythrocyte_physiolo1.42175483
46MP0010352_gastrointestinal_tract_polyps1.42024158
47MP0003943_abnormal_hepatobiliary_system1.41668482
48MP0003123_paternal_imprinting1.39969620
49MP0000685_abnormal_immune_system1.39360001
50MP0005551_abnormal_eye_electrophysiolog1.39083674
51MP0001800_abnormal_humoral_immune1.38957933
52MP0008932_abnormal_embryonic_tissue1.37672168
53MP0004142_abnormal_muscle_tone1.37462218
54MP0009333_abnormal_splenocyte_physiolog1.37236120
55MP0000350_abnormal_cell_proliferation1.34664763
56MP0005187_abnormal_penis_morphology1.33761384
57MP0001879_abnormal_lymphatic_vessel1.33672156
58MP0000647_abnormal_sebaceous_gland1.33380855
59MP0009785_altered_susceptibility_to1.33215400
60MP0005220_abnormal_exocrine_pancreas1.33166309
61MP0002420_abnormal_adaptive_immunity1.30684257
62MP0001984_abnormal_olfaction1.29419608
63MP0002452_abnormal_antigen_presenting1.29306101
64MP0001819_abnormal_immune_cell1.28768503
65MP0003221_abnormal_cardiomyocyte_apopto1.27958734
66MP0003121_genomic_imprinting1.27756447
67MP0002638_abnormal_pupillary_reflex1.26726797
68MP0003950_abnormal_plasma_membrane1.25663641
69MP0002006_tumorigenesis1.22921640
70MP0001177_atelectasis1.22572020
71MP0002723_abnormal_immune_serum1.22122435
72MP0000703_abnormal_thymus_morphology1.21429167
73MP0006035_abnormal_mitochondrial_morpho1.19050525
74MP0001873_stomach_inflammation1.18655123
75MP0000490_abnormal_crypts_of1.17792076
76MP0002132_abnormal_respiratory_system1.17683272
77MP0005257_abnormal_intraocular_pressure1.17682552
78MP0005000_abnormal_immune_tolerance1.17441339
79MP0000465_gastrointestinal_hemorrhage1.17294085
80MP0000689_abnormal_spleen_morphology1.17133981
81MP0001119_abnormal_female_reproductive1.15841785
82MP0006036_abnormal_mitochondrial_physio1.15658998
83MP0002933_joint_inflammation1.15108160
84MP0001929_abnormal_gametogenesis1.14274883
85MP0002166_altered_tumor_susceptibility1.13842319
86MP0000716_abnormal_immune_system1.12586806
87MP0002722_abnormal_immune_system1.12010732
88MP0003786_premature_aging1.08625309
89MP0002019_abnormal_tumor_incidence1.07163103
90MP0003718_maternal_effect1.05248962
91MP0002148_abnormal_hypersensitivity_rea1.04367147
92MP0002429_abnormal_blood_cell1.04143598
93MP0001672_abnormal_embryogenesis/_devel1.04012844
94MP0005380_embryogenesis_phenotype1.04012844
95MP0002254_reproductive_system_inflammat1.03456888
96MP0003828_pulmonary_edema1.02013552
97MP0005084_abnormal_gallbladder_morpholo1.01262766
98MP0005395_other_phenotype0.99592927
99MP0002160_abnormal_reproductive_system0.99297294
100MP0001697_abnormal_embryo_size0.99199793
101MP0002405_respiratory_system_inflammati0.99053687
102MP0001293_anophthalmia0.98525428
103MP0001790_abnormal_immune_system0.98310023
104MP0005387_immune_system_phenotype0.98310023
105MP0001764_abnormal_homeostasis0.98044075
106MP0003984_embryonic_growth_retardation0.97975866
107MP0000566_synostosis0.97749821
108MP0002088_abnormal_embryonic_growth/wei0.97251166
109MP0004043_abnormal_pH_regulation0.97077218
110MP0001730_embryonic_growth_arrest0.94541025
111MP0005408_hypopigmentation0.93901706
112MP0003890_abnormal_embryonic-extraembry0.92775471
113MP0001188_hyperpigmentation0.92255294
114MP0002210_abnormal_sex_determination0.91516023
115MP0001545_abnormal_hematopoietic_system0.91008056
116MP0005397_hematopoietic_system_phenotyp0.91008056
117MP0002086_abnormal_extraembryonic_tissu0.90373474
118MP0000631_abnormal_neuroendocrine_gland0.89689156
119MP0003937_abnormal_limbs/digits/tail_de0.88582062
120MP0008872_abnormal_physiological_respon0.86599060
121MP0010678_abnormal_skin_adnexa0.86503398
122MP0002249_abnormal_larynx_morphology0.86188920
123MP0002419_abnormal_innate_immunity0.85756353
124MP0000313_abnormal_cell_death0.85229956
125MP0003567_abnormal_fetal_cardiomyocyte0.85172624
126MP0002233_abnormal_nose_morphology0.85015883
127MP0002095_abnormal_skin_pigmentation0.84998528
128MP0008789_abnormal_olfactory_epithelium0.84837995
129MP0003186_abnormal_redox_activity0.84380909
130MP0003136_yellow_coat_color0.83186885
131MP0002085_abnormal_embryonic_tissue0.82215889
132MP0009046_muscle_twitch0.82129458
133MP0004197_abnormal_fetal_growth/weight/0.80747414
134MP0009250_abnormal_appendicular_skeleto0.80483392
135MP0005389_reproductive_system_phenotype0.80123600
136MP0003755_abnormal_palate_morphology0.79530747
137MP0005332_abnormal_amino_acid0.78862377
138MP0003119_abnormal_digestive_system0.78489109
139MP0005025_abnormal_response_to0.78408702
140MP0004133_heterotaxia0.77889991
141MP0009703_decreased_birth_body0.77477382
142MP0000013_abnormal_adipose_tissue0.76578039
143MP0005076_abnormal_cell_differentiation0.76402679
144MP0000383_abnormal_hair_follicle0.75782462
145MP0001175_abnormal_lung_morphology0.74961190
146MP0003698_abnormal_male_reproductive0.74571431
147MP0000653_abnormal_sex_gland0.74434357
148MP0002163_abnormal_gland_morphology0.73943405
149MP0002090_abnormal_vision0.73229827
150MP0001286_abnormal_eye_development0.72733824
151MP0003448_altered_tumor_morphology0.72466904
152MP0005508_abnormal_skeleton_morphology0.71354679
153MP0003787_abnormal_imprinting0.71188434
154MP0003941_abnormal_skin_development0.70877477
155MP0002080_prenatal_lethality0.70053117
156MP0010155_abnormal_intestine_physiology0.69524719
157MP0001853_heart_inflammation0.69390187
158MP0001145_abnormal_male_reproductive0.69345835
159MP0000358_abnormal_cell_content/0.68135371
160MP0002084_abnormal_developmental_patter0.67632182
161MP0005645_abnormal_hypothalamus_physiol0.66280854
162MP0005248_abnormal_Harderian_gland0.65863173
163MP0001486_abnormal_startle_reflex0.64684727
164MP0005379_endocrine/exocrine_gland_phen0.64558116

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)3.49069367
2Volvulus (HP:0002580)3.46548281
3Tubulointerstitial nephritis (HP:0001970)3.46461461
4Abnormality of the labia minora (HP:0012880)3.45033884
5Chromsome breakage (HP:0040012)3.43639197
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14967559
7Medial flaring of the eyebrow (HP:0010747)3.12125499
8Prostate neoplasm (HP:0100787)3.07544812
9Gait imbalance (HP:0002141)3.03291577
10Congenital primary aphakia (HP:0007707)3.00284513
11Birth length less than 3rd percentile (HP:0003561)2.97379770
12Nephrogenic diabetes insipidus (HP:0009806)2.84951491
13Abnormality of chromosome stability (HP:0003220)2.83797465
14IgM deficiency (HP:0002850)2.81767494
15Colon cancer (HP:0003003)2.76019373
16Flat capital femoral epiphysis (HP:0003370)2.67414447
17Medulloblastoma (HP:0002885)2.61137743
18Genital tract atresia (HP:0001827)2.58067482
19Abnormality of the fingertips (HP:0001211)2.57350246
20Delayed epiphyseal ossification (HP:0002663)2.56953143
21Progressive inability to walk (HP:0002505)2.54497473
22Embryonal renal neoplasm (HP:0011794)2.54162738
23Abnormality of vitamin B metabolism (HP:0004340)2.53961431
24Abnormality of the vitamin B12 metabolism (HP:0004341)2.49497308
25Acute myeloid leukemia (HP:0004808)2.47994318
26Optic neuritis (HP:0100653)2.46722710
27Retrobulbar optic neuritis (HP:0100654)2.46722710
28Capillary hemangiomas (HP:0005306)2.45202210
29Short 4th metacarpal (HP:0010044)2.44998152
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44998152
31Vaginal atresia (HP:0000148)2.42544136
32Methylmalonic aciduria (HP:0012120)2.41801362
33Poor coordination (HP:0002370)2.38312858
34Thyroiditis (HP:0100646)2.36737611
35Enlarged epiphyses (HP:0010580)2.35204564
36Abnormality of the prostate (HP:0008775)2.33263161
37Severe combined immunodeficiency (HP:0004430)2.27543633
38Generalized aminoaciduria (HP:0002909)2.25911970
39Ependymoma (HP:0002888)2.25761114
40Glioma (HP:0009733)2.22458736
41Optic nerve coloboma (HP:0000588)2.20385915
42Ectopic kidney (HP:0000086)2.19562669
43Renal cortical cysts (HP:0000803)2.15449318
44Pancreatic fibrosis (HP:0100732)2.12829137
45Myositis (HP:0100614)2.12477353
46Myelodysplasia (HP:0002863)2.12307927
47Molar tooth sign on MRI (HP:0002419)2.12307215
48Abnormality of midbrain morphology (HP:0002418)2.12307215
49Thrombocytosis (HP:0001894)2.11592927
50Abnormality of methionine metabolism (HP:0010901)2.09666130
51IgG deficiency (HP:0004315)2.08882576
52Hyperglycinemia (HP:0002154)2.07439781
53Patchy hypopigmentation of hair (HP:0011365)2.06854477
54Orchitis (HP:0100796)2.06702361
55Deep philtrum (HP:0002002)2.06202786
56Abnormality of DNA repair (HP:0003254)2.05058339
57Combined immunodeficiency (HP:0005387)2.04941128
58Neoplasm of the adrenal gland (HP:0100631)2.04682277
59Type I transferrin isoform profile (HP:0003642)2.04459214
60Lymphoma (HP:0002665)2.03833270
61Fair hair (HP:0002286)2.02012197
62Progressive macrocephaly (HP:0004481)2.01106324
63Abnormality of the pons (HP:0007361)2.00818312
64Duodenal stenosis (HP:0100867)2.00373933
65Small intestinal stenosis (HP:0012848)2.00373933
66Papillary thyroid carcinoma (HP:0002895)1.99918850
67Agnosia (HP:0010524)1.98746345
68Abnormality of the ileum (HP:0001549)1.98231554
69Astrocytoma (HP:0009592)1.97928811
70Abnormality of the astrocytes (HP:0100707)1.97928811
71Biliary tract neoplasm (HP:0100574)1.97599583
72Nephroblastoma (Wilms tumor) (HP:0002667)1.97325348
73Hypoglycemic seizures (HP:0002173)1.96601147
74Facial hemangioma (HP:0000329)1.96542059
75Long clavicles (HP:0000890)1.96151509
76T lymphocytopenia (HP:0005403)1.95642229
77Meckel diverticulum (HP:0002245)1.95419703
78Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95097628
79Hypoproteinemia (HP:0003075)1.94424229
80Acute necrotizing encephalopathy (HP:0006965)1.94209896
81White forelock (HP:0002211)1.94185022
82Amaurosis fugax (HP:0100576)1.93513967
83Symptomatic seizures (HP:0011145)1.93161871
84Acute encephalopathy (HP:0006846)1.92613561
85Abnormal hair whorl (HP:0010721)1.92477112
86Abnormality of the renal cortex (HP:0011035)1.92037859
87Increased CSF lactate (HP:0002490)1.91285823
88Abnormality of T cell number (HP:0011839)1.90646938
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89009811
90Abnormal protein N-linked glycosylation (HP:0012347)1.89009811
91Abnormal protein glycosylation (HP:0012346)1.89009811
92Abnormal glycosylation (HP:0012345)1.89009811
93Astigmatism (HP:0000483)1.88787101
94Gaze-evoked nystagmus (HP:0000640)1.88086305
95Widely patent fontanelles and sutures (HP:0004492)1.87381720
96Abnormality of lateral ventricle (HP:0030047)1.85981941
97Lip pit (HP:0100267)1.85544041
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.85520395
99Clubbing of toes (HP:0100760)1.85335248
100B lymphocytopenia (HP:0010976)1.85265606
101Abnormality of B cell number (HP:0010975)1.85265606
102Pancreatic cysts (HP:0001737)1.84409199
103Neoplasm of the oral cavity (HP:0100649)1.83922529
104Hypoplasia of the pons (HP:0012110)1.83804106
105Specific learning disability (HP:0001328)1.83382269
106Hepatocellular necrosis (HP:0001404)1.82908924
107Irregular epiphyses (HP:0010582)1.82396979
108Abnormality of the duodenum (HP:0002246)1.82238940
109Stenosis of the external auditory canal (HP:0000402)1.82235714
110Broad foot (HP:0001769)1.81533371
111Thin bony cortex (HP:0002753)1.81464352
112Sparse lateral eyebrow (HP:0005338)1.81195347
113Curly hair (HP:0002212)1.81174224
114Neoplasm of the adrenal cortex (HP:0100641)1.80970999
115IgA deficiency (HP:0002720)1.79667365
116Median cleft lip (HP:0000161)1.79316636
117Sloping forehead (HP:0000340)1.79126974
118Pheochromocytoma (HP:0002666)1.78628190
119Abnormality of the preputium (HP:0100587)1.78574438
120Stomach cancer (HP:0012126)1.78370722
121Spinal cord lesions (HP:0100561)1.78241960
122Syringomyelia (HP:0003396)1.78241960
123Patellar aplasia (HP:0006443)1.76851278
124Selective tooth agenesis (HP:0001592)1.76799899
125Blepharitis (HP:0000498)1.76582660
126Rhabdomyosarcoma (HP:0002859)1.76499983
127Decreased testicular size (HP:0008734)1.75970669
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.75739363
129Duplicated collecting system (HP:0000081)1.75518882
130Bell-shaped thorax (HP:0001591)1.75379831
131Subacute progressive viral hepatitis (HP:0006572)1.75376839
132Abnormal lung lobation (HP:0002101)1.74963613
133Postaxial hand polydactyly (HP:0001162)1.74648311
134Missing ribs (HP:0000921)1.74569658
135Abnormality of the carotid arteries (HP:0005344)1.73657597
136Inability to walk (HP:0002540)1.73495357
137Thyroid carcinoma (HP:0002890)1.73292036
138Neuroendocrine neoplasm (HP:0100634)1.71472859
139Intestinal atresia (HP:0011100)1.70910148
140Hypothermia (HP:0002045)1.70245409
141Mitochondrial inheritance (HP:0001427)1.69942218
142Metaphyseal dysplasia (HP:0100255)1.68699740
143Reduced antithrombin III activity (HP:0001976)1.68456704
144Abnormality of the hepatic vasculature (HP:0006707)1.68273246
145Hyperinsulinemic hypoglycemia (HP:0000825)1.68119030
146Pancreatic islet-cell hyperplasia (HP:0004510)1.67667128
147Abnormality of eosinophils (HP:0001879)1.67579824
148Bone marrow hypocellularity (HP:0005528)1.67307481
149Wide cranial sutures (HP:0010537)1.66871506
150Deviation of the thumb (HP:0009603)1.65219836
151Cortical dysplasia (HP:0002539)1.65100911
152Abnormality of the hip-girdle musculature (HP:0001445)1.64764181
153Abnormality of the musculature of the pelvis (HP:0001469)1.64764181
154Hepatic necrosis (HP:0002605)1.64163805
155Chronic diarrhea (HP:0002028)1.64132275
156Nephronophthisis (HP:0000090)1.64082420
157Portal hypertension (HP:0001409)1.63633841
158Supernumerary spleens (HP:0009799)1.63490139
159Bile duct proliferation (HP:0001408)1.63293773
160Abnormal biliary tract physiology (HP:0012439)1.63293773
161Neoplasm of the colon (HP:0100273)1.63070711
162True hermaphroditism (HP:0010459)1.62789761
163Rib fusion (HP:0000902)1.62399221
164Abnormal spermatogenesis (HP:0008669)1.62221914
165Severe visual impairment (HP:0001141)1.62067813
16611 pairs of ribs (HP:0000878)1.61871270
167Abnormality of T cells (HP:0002843)1.61274115
168Keratoconjunctivitis sicca (HP:0001097)1.61172238
169Abnormality of the columella (HP:0009929)1.60613741
170Adrenal hypoplasia (HP:0000835)1.59335606
171Chronic hepatic failure (HP:0100626)1.59295494
172Abnormality of incisor morphology (HP:0011063)1.58882839
173Abnormality of the renal collecting system (HP:0004742)1.58469619
174Abnormality of the renal medulla (HP:0100957)1.56578480
175Premature graying of hair (HP:0002216)1.56556287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.51310235
2TXK3.74510600
3TRIM283.16686521
4EIF2AK12.91284875
5NUAK12.76354080
6ZAK2.37148293
7TSSK62.33947697
8EIF2AK32.27180179
9BCR2.24933035
10PIK3CA2.18857421
11ACVR1B2.15876639
12LATS12.02874501
13SRPK11.94780425
14CDC71.91583931
15PLK41.88696702
16STK241.86356306
17MAPK131.86311844
18MAP4K21.82786873
19MAP4K11.77358872
20NEK21.77019822
21VRK11.72223541
22CDK81.68905358
23FLT31.65013704
24BUB11.64937064
25MAP3K41.61917588
26FRK1.60557424
27MKNK11.59071947
28TGFBR11.54284361
29TEC1.51119170
30TTK1.48538674
31CCNB11.46163957
32STK31.46145037
33EIF2AK21.42834102
34PLK31.39002684
35CASK1.38019559
36MKNK21.37115428
37IRAK41.34862280
38MST1R1.33722180
39PNCK1.32986342
40CDK121.31269939
41ATR1.30994046
42AKT31.30965150
43TNIK1.30508781
44STK101.28773932
45ERBB31.27948740
46TIE11.27811085
47JAK31.26518638
48MAP2K71.21496318
49MAP3K141.20962332
50PLK21.20775762
51CSF1R1.19387222
52STK38L1.16391109
53NLK1.14163662
54BRSK21.12179507
55IRAK31.09139067
56DYRK31.08795072
57WEE11.08503513
58AURKB1.06377331
59PAK31.05823523
60BMPR1B1.05032971
61BCKDK1.03993992
62STK161.03269398
63BRD41.03125511
64YES11.02411911
65EPHA31.02028086
66PASK0.99479582
67PBK0.99027542
68MET0.98126778
69CHUK0.97221561
70PIM10.96749886
71STK390.96521660
72PLK10.95778771
73CHEK20.94629292
74IKBKB0.93637276
75OXSR10.90209670
76KIT0.88475060
77ATM0.87753557
78MST40.86864322
79STK40.86351634
80BTK0.83828116
81TGFBR20.80313975
82MAP3K60.79703068
83RPS6KA40.78511926
84CSNK1G20.78397972
85PINK10.77858743
86MARK10.77189140
87ITK0.75461417
88CDK70.74570746
89IKBKE0.74262593
90PRKCE0.72013297
91NEK10.71679479
92CHEK10.71466488
93MELK0.71164203
94RPS6KB20.70654922
95CDK90.70292128
96EEF2K0.69698509
97TLK10.69433423
98TRPM70.67338666
99CLK10.62693693
100NEK90.62208289
101CDK30.60505040
102INSRR0.60460375
103SGK20.59936662
104NEK60.58856869
105OBSCN0.58394914
106MAP3K80.54910361
107CSNK1G10.53342228
108DYRK20.53072483
109ZAP700.52835408
110PHKG10.52580893
111PHKG20.52580893
112MAP3K50.52250660
113CSNK1A1L0.52121564
114TAF10.51382164
115GRK10.50610083
116LCK0.50598301
117SIK30.50308796
118EPHA20.47086232
119TAOK30.47080375
120LYN0.46762770
121CDK40.46750066
122PRKCG0.46017883
123ERBB40.44843468
124BRSK10.44649551
125MAPK110.44295921
126KSR10.42652861
127RPS6KA50.41894995
128CDK10.41644366
129RPS6KB10.41581770
130CSNK1D0.41231996
131CSNK1G30.40428747
132ADRBK20.40248733
133SGK30.39976405
134PDK20.38945371
135MARK30.38864677
136TYK20.37639697
137CAMKK20.36560294
138FGFR10.36243689
139DYRK1A0.35526230
140VRK20.34667186
141BRAF0.31422871
142PKN10.30621469
143MAP2K40.30308633
144PIK3CG0.28909371
145PRKCI0.28738473
146ADRBK10.28673845
147FER0.27403400
148CSNK1E0.27384679

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.67342522
2DNA replication_Homo sapiens_hsa030302.64211277
3Propanoate metabolism_Homo sapiens_hsa006402.55115911
4Cell cycle_Homo sapiens_hsa041102.47771160
5RNA polymerase_Homo sapiens_hsa030202.43151587
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42036994
7Basal transcription factors_Homo sapiens_hsa030222.40856146
8Base excision repair_Homo sapiens_hsa034102.40198056
9Homologous recombination_Homo sapiens_hsa034402.29956930
10Fanconi anemia pathway_Homo sapiens_hsa034602.20070194
11RNA transport_Homo sapiens_hsa030132.13664725
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13375014
13Non-homologous end-joining_Homo sapiens_hsa034502.05166270
14RNA degradation_Homo sapiens_hsa030182.03071509
15Spliceosome_Homo sapiens_hsa030401.99294362
16Nucleotide excision repair_Homo sapiens_hsa034201.88069790
17Selenocompound metabolism_Homo sapiens_hsa004501.81001926
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75524288
19Primary immunodeficiency_Homo sapiens_hsa053401.73462026
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70706974
21Herpes simplex infection_Homo sapiens_hsa051681.68839142
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.67758260
23p53 signaling pathway_Homo sapiens_hsa041151.60367556
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57245552
25Butanoate metabolism_Homo sapiens_hsa006501.55727871
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55377123
27Steroid biosynthesis_Homo sapiens_hsa001001.53131997
28Measles_Homo sapiens_hsa051621.48425843
29Allograft rejection_Homo sapiens_hsa053301.48221866
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.47996749
31Hematopoietic cell lineage_Homo sapiens_hsa046401.44597279
32Oxidative phosphorylation_Homo sapiens_hsa001901.44102158
33Protein export_Homo sapiens_hsa030601.40253387
34Antigen processing and presentation_Homo sapiens_hsa046121.39088510
35Pyrimidine metabolism_Homo sapiens_hsa002401.35636706
36mRNA surveillance pathway_Homo sapiens_hsa030151.33518193
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30713174
38Legionellosis_Homo sapiens_hsa051341.27592364
39One carbon pool by folate_Homo sapiens_hsa006701.26601550
40Autoimmune thyroid disease_Homo sapiens_hsa053201.23027401
41Sulfur metabolism_Homo sapiens_hsa009201.22423263
42Parkinsons disease_Homo sapiens_hsa050121.19077126
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.18522194
44Epstein-Barr virus infection_Homo sapiens_hsa051691.17283424
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16611859
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.14122743
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13796570
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13562463
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10498299
50Fatty acid elongation_Homo sapiens_hsa000621.10397309
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10290783
52Systemic lupus erythematosus_Homo sapiens_hsa053221.09083369
53Viral carcinogenesis_Homo sapiens_hsa052031.07837462
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.06828627
55Oocyte meiosis_Homo sapiens_hsa041141.06601397
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01128636
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98248379
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96996555
59HTLV-I infection_Homo sapiens_hsa051660.96801592
60Leishmaniasis_Homo sapiens_hsa051400.96480574
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96472866
62MicroRNAs in cancer_Homo sapiens_hsa052060.94556281
63Purine metabolism_Homo sapiens_hsa002300.94014713
64Influenza A_Homo sapiens_hsa051640.93784574
65Peroxisome_Homo sapiens_hsa041460.91395109
66T cell receptor signaling pathway_Homo sapiens_hsa046600.89880244
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89758651
68Malaria_Homo sapiens_hsa051440.89175103
69Colorectal cancer_Homo sapiens_hsa052100.89096054
70Hepatitis B_Homo sapiens_hsa051610.88861829
71Proteasome_Homo sapiens_hsa030500.85610466
72Apoptosis_Homo sapiens_hsa042100.85287026
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84972647
74TGF-beta signaling pathway_Homo sapiens_hsa043500.84509237
75Small cell lung cancer_Homo sapiens_hsa052220.84126120
76Type I diabetes mellitus_Homo sapiens_hsa049400.82087457
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81509956
78Adherens junction_Homo sapiens_hsa045200.80696942
79Thyroid cancer_Homo sapiens_hsa052160.77647856
80Huntingtons disease_Homo sapiens_hsa050160.77412428
81Asthma_Homo sapiens_hsa053100.75998260
82FoxO signaling pathway_Homo sapiens_hsa040680.75468063
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75120445
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.75018333
85Toxoplasmosis_Homo sapiens_hsa051450.74909996
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74355192
87Ribosome_Homo sapiens_hsa030100.73767208
88Viral myocarditis_Homo sapiens_hsa054160.72718260
89Nicotine addiction_Homo sapiens_hsa050330.71573598
90B cell receptor signaling pathway_Homo sapiens_hsa046620.71153411
91TNF signaling pathway_Homo sapiens_hsa046680.70975312
92Graft-versus-host disease_Homo sapiens_hsa053320.69479476
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68920641
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68704480
95Prostate cancer_Homo sapiens_hsa052150.67857080
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67553173
97Caffeine metabolism_Homo sapiens_hsa002320.67137257
98Osteoclast differentiation_Homo sapiens_hsa043800.65832791
99Pathways in cancer_Homo sapiens_hsa052000.65679483
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65360411
101Folate biosynthesis_Homo sapiens_hsa007900.63575872
102Glutathione metabolism_Homo sapiens_hsa004800.63438485
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62608613
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62581879
105Vitamin B6 metabolism_Homo sapiens_hsa007500.62087884
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.59902284
107Ether lipid metabolism_Homo sapiens_hsa005650.59051935
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58968002
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57264734
110Circadian rhythm_Homo sapiens_hsa047100.57067632
111Hepatitis C_Homo sapiens_hsa051600.56930225
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56684224
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55924134
114Nitrogen metabolism_Homo sapiens_hsa009100.55194557
115Collecting duct acid secretion_Homo sapiens_hsa049660.54930126
116Metabolic pathways_Homo sapiens_hsa011000.54390763
117Pancreatic cancer_Homo sapiens_hsa052120.54360388
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52701371
119Hippo signaling pathway_Homo sapiens_hsa043900.52027493
120Chronic myeloid leukemia_Homo sapiens_hsa052200.51829340
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51820735
122Sphingolipid metabolism_Homo sapiens_hsa006000.50270374
123Platelet activation_Homo sapiens_hsa046110.48786865
124Pyruvate metabolism_Homo sapiens_hsa006200.48056463
125Tuberculosis_Homo sapiens_hsa051520.47980862
126ECM-receptor interaction_Homo sapiens_hsa045120.47535670
127Regulation of autophagy_Homo sapiens_hsa041400.47252850
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47244223
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46952349
130Phototransduction_Homo sapiens_hsa047440.46821881
131N-Glycan biosynthesis_Homo sapiens_hsa005100.46648027
132Endometrial cancer_Homo sapiens_hsa052130.46273168
133Acute myeloid leukemia_Homo sapiens_hsa052210.45585164
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44893468
135Chemokine signaling pathway_Homo sapiens_hsa040620.44559063
136Basal cell carcinoma_Homo sapiens_hsa052170.44493032
137Fatty acid metabolism_Homo sapiens_hsa012120.44451375
138Long-term depression_Homo sapiens_hsa047300.43878582
139beta-Alanine metabolism_Homo sapiens_hsa004100.43487454
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43395089
141Alzheimers disease_Homo sapiens_hsa050100.43090639
142Other glycan degradation_Homo sapiens_hsa005110.42872877
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42540020
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42479666
145Linoleic acid metabolism_Homo sapiens_hsa005910.41740618
146Chemical carcinogenesis_Homo sapiens_hsa052040.39028828
147Taste transduction_Homo sapiens_hsa047420.38944436
148Olfactory transduction_Homo sapiens_hsa047400.35098474
149Alcoholism_Homo sapiens_hsa050340.35091189
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35043160
151ABC transporters_Homo sapiens_hsa020100.34114210
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32812419
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30446511
154Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29119309
155Tryptophan metabolism_Homo sapiens_hsa003800.28308363
156Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23687673
157Retinol metabolism_Homo sapiens_hsa008300.20251097
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19924653
159Hedgehog signaling pathway_Homo sapiens_hsa043400.18726232
160Vitamin digestion and absorption_Homo sapiens_hsa049770.17582652
161Fatty acid degradation_Homo sapiens_hsa000710.17509313

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