MYO10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.23294579
2melanin biosynthetic process (GO:0042438)4.52485144
3regulation of gene silencing by RNA (GO:0060966)4.41741872
4regulation of posttranscriptional gene silencing (GO:0060147)4.41741872
5regulation of gene silencing by miRNA (GO:0060964)4.41741872
6cellular potassium ion homeostasis (GO:0030007)4.35955376
7nuclear pore complex assembly (GO:0051292)4.23086278
8notochord development (GO:0030903)4.21893032
9nuclear pore organization (GO:0006999)3.99909353
10dermatan sulfate biosynthetic process (GO:0030208)3.99156068
11secondary metabolite biosynthetic process (GO:0044550)3.92477387
12regulation of hippo signaling (GO:0035330)3.89135526
13melanin metabolic process (GO:0006582)3.80901743
14hippo signaling (GO:0035329)3.70535879
15dorsal/ventral axis specification (GO:0009950)3.68563215
16vascular endothelial growth factor signaling pathway (GO:0038084)3.67085278
17dermatan sulfate metabolic process (GO:0030205)3.53960509
18establishment of apical/basal cell polarity (GO:0035089)3.51368842
19regulation of SMAD protein import into nucleus (GO:0060390)3.50091199
20positive regulation of SMAD protein import into nucleus (GO:0060391)3.45736121
21regulation of DNA endoreduplication (GO:0032875)3.45126705
22polarized epithelial cell differentiation (GO:0030859)3.42482902
23anterior/posterior axis specification, embryo (GO:0008595)3.39869703
24cell migration involved in sprouting angiogenesis (GO:0002042)3.36553543
25cell proliferation in forebrain (GO:0021846)3.35534925
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.34612464
27endothelial cell morphogenesis (GO:0001886)3.27163950
28plasma membrane repair (GO:0001778)3.27013253
29basement membrane organization (GO:0071711)3.24135517
30positive regulation of p38MAPK cascade (GO:1900745)3.21429765
31hemidesmosome assembly (GO:0031581)3.20353628
32artery development (GO:0060840)3.19213266
33sulfation (GO:0051923)3.17973579
34endodermal cell differentiation (GO:0035987)3.17736047
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.15488849
36neuron remodeling (GO:0016322)3.13551816
37regulation of tight junction assembly (GO:2000810)3.11966198
38pore complex assembly (GO:0046931)3.11100169
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06079316
40cell adhesion mediated by integrin (GO:0033627)3.03521878
41smooth muscle tissue development (GO:0048745)3.02910761
42embryonic camera-type eye development (GO:0031076)3.00598682
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99094905
44lateral sprouting from an epithelium (GO:0060601)2.98337874
45epithelial cell-cell adhesion (GO:0090136)2.97094223
46apoptotic cell clearance (GO:0043277)2.95962748
47regulation of mitotic spindle organization (GO:0060236)2.94283077
48wound healing, spreading of epidermal cells (GO:0035313)2.93987839
49negative regulation of keratinocyte proliferation (GO:0010839)2.92909769
50negative regulation of protein localization to cell surface (GO:2000009)2.89968696
51negative regulation of axon guidance (GO:1902668)2.88566239
52lymphangiogenesis (GO:0001946)2.88447231
53negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.86868054
54apoptotic process involved in morphogenesis (GO:0060561)2.84711022
55heterochromatin organization (GO:0070828)2.84552246
56branching involved in salivary gland morphogenesis (GO:0060445)2.84463510
57ovulation cycle (GO:0042698)2.83654984
58chondrocyte proliferation (GO:0035988)2.83653336
59presynaptic membrane assembly (GO:0097105)2.83367412
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81589782
61negative chemotaxis (GO:0050919)2.81077357
62mesenchymal-epithelial cell signaling (GO:0060638)2.80898705
63adherens junction assembly (GO:0034333)2.80581640
64embryonic process involved in female pregnancy (GO:0060136)2.79387088
65regulation of mesoderm development (GO:2000380)2.79197930
66establishment or maintenance of monopolar cell polarity (GO:0061339)2.78593679
67establishment of monopolar cell polarity (GO:0061162)2.78593679
68positive regulation of endothelial cell apoptotic process (GO:2000353)2.77937674
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77556494
70glomerular basement membrane development (GO:0032836)2.77053838
71protein heterotrimerization (GO:0070208)2.76228787
72Notch signaling involved in heart development (GO:0061314)2.75790403
73cell-substrate junction assembly (GO:0007044)2.75657667
74lung-associated mesenchyme development (GO:0060484)2.75503598
75regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.73718564
76blood vessel endothelial cell migration (GO:0043534)2.73706508
77embryonic placenta development (GO:0001892)2.73120257
78mammary gland development (GO:0030879)2.72830771
79regulation of p38MAPK cascade (GO:1900744)2.72783486
80kidney mesenchyme development (GO:0072074)2.71271949
81axon extension involved in axon guidance (GO:0048846)2.71240863
82neuron projection extension involved in neuron projection guidance (GO:1902284)2.71240863
83regulation of axon extension involved in axon guidance (GO:0048841)2.69337455
84cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68873863
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.68475811
86cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68230209
87negative regulation of chondrocyte differentiation (GO:0032331)2.67419614
88NLS-bearing protein import into nucleus (GO:0006607)2.66391392
89membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.66144964
90regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.63354907
91developmental induction (GO:0031128)2.63195152
92cell-cell signaling involved in cell fate commitment (GO:0045168)2.61901573
93pre-miRNA processing (GO:0031054)2.61864308
94retina vasculature morphogenesis in camera-type eye (GO:0061299)2.60220911
95regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.59712854
96collagen fibril organization (GO:0030199)2.58824195
97regulation of integrin activation (GO:0033623)2.57896023
98postsynaptic membrane organization (GO:0001941)2.57423560
99renal filtration (GO:0097205)2.54144866
100vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.53380285
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52760840
102otic vesicle formation (GO:0030916)2.50708488
103myelination in peripheral nervous system (GO:0022011)2.50380818
104peripheral nervous system axon ensheathment (GO:0032292)2.50380818
105auditory behavior (GO:0031223)2.50223501
106regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48986284
107endocardial cushion development (GO:0003197)2.48940797
108folic acid-containing compound biosynthetic process (GO:0009396)2.47532775
109organ induction (GO:0001759)2.47424641
110regulation of axon guidance (GO:1902667)2.47222251
111outer ear morphogenesis (GO:0042473)2.46006605
112regulation of somitogenesis (GO:0014807)2.45668978
113positive regulation of mesenchymal cell proliferation (GO:0002053)2.44920479
114negative regulation of catenin import into nucleus (GO:0035414)2.44564745
115aorta morphogenesis (GO:0035909)2.44393777
116mesenchyme development (GO:0060485)2.44215043
117regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43180697
118renal system development (GO:0072001)2.42681993
119positive regulation of neuroblast proliferation (GO:0002052)2.41999634
120retinal ganglion cell axon guidance (GO:0031290)2.41974834
121presynaptic membrane organization (GO:0097090)2.41337581
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.40469848
123regulation of cell fate specification (GO:0042659)2.40393391
124wound healing, spreading of cells (GO:0044319)2.40349457
125substrate adhesion-dependent cell spreading (GO:0034446)2.39940950
126negative regulation of embryonic development (GO:0045992)2.39761556
127cell-substrate adherens junction assembly (GO:0007045)2.38375883
128focal adhesion assembly (GO:0048041)2.38375883
129craniofacial suture morphogenesis (GO:0097094)2.38242012
130magnesium ion transport (GO:0015693)2.38172406
131negative regulation of cartilage development (GO:0061037)2.36982814
132DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.36353430
133lymph vessel development (GO:0001945)2.36047998
134regulation of translational fidelity (GO:0006450)2.36047211
135dendritic spine morphogenesis (GO:0060997)2.35734328
136regulation of spindle organization (GO:0090224)2.35308565
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35295743
138regulation of mesenchymal cell proliferation (GO:0010464)2.35269101
139embryonic hindlimb morphogenesis (GO:0035116)2.34540734
140IMP biosynthetic process (GO:0006188)2.33884337
141regulation of protein polyubiquitination (GO:1902914)2.33687413
142neural crest cell development (GO:0014032)2.33251586
143atrioventricular valve morphogenesis (GO:0003181)2.33223791
144gap junction assembly (GO:0016264)2.33034323
145regulation of neuroblast proliferation (GO:1902692)2.32750726
146pattern specification involved in kidney development (GO:0061004)2.32579177
147cranial suture morphogenesis (GO:0060363)2.32534317
148fibroblast migration (GO:0010761)2.32445380
149regulation of heart morphogenesis (GO:2000826)2.32114539
150limb bud formation (GO:0060174)2.31718896
151membrane repolarization during action potential (GO:0086011)2.30964698
152positive regulation of hormone biosynthetic process (GO:0046886)2.30931480
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.30833479
154positive regulation of epithelial to mesenchymal transition (GO:0010718)2.29631984
155glomerular visceral epithelial cell development (GO:0072015)2.28697941
156metanephric mesenchyme development (GO:0072075)2.28623955
157cell migration involved in heart development (GO:0060973)2.28507145
158ventricular septum development (GO:0003281)2.28096066
159cochlea morphogenesis (GO:0090103)2.27980413
160morphogenesis of an epithelial sheet (GO:0002011)2.27798022
161glomerular filtration (GO:0003094)2.27484818
162righting reflex (GO:0060013)2.26723497
163establishment of planar polarity (GO:0001736)2.26599921
164establishment of tissue polarity (GO:0007164)2.26599921
165semaphorin-plexin signaling pathway (GO:0071526)2.26042478
166hindlimb morphogenesis (GO:0035137)2.22697533
167desmosome organization (GO:0002934)2.22593217
168potassium ion import (GO:0010107)2.22321835
169cell migration involved in gastrulation (GO:0042074)2.21830584
170DNA damage response, signal transduction resulting in transcription (GO:0042772)2.20651001
171negative regulation of stem cell proliferation (GO:2000647)2.19144241
172membrane assembly (GO:0071709)2.18881735
173negative regulation of cardiac muscle tissue development (GO:0055026)2.18581081
174potassium ion homeostasis (GO:0055075)2.16701420
175ganglion development (GO:0061548)2.16182232
176embryonic foregut morphogenesis (GO:0048617)2.14505705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.97323952
2E2F7_22180533_ChIP-Seq_HELA_Human3.89833739
3EZH2_22144423_ChIP-Seq_EOC_Human3.69466183
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.64185791
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.64185791
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.64185791
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.35949964
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.09099918
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94538291
10ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.93129479
11* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.90865174
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.87818829
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.83354552
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.75150360
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.72853608
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.71611363
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59485266
18GBX2_23144817_ChIP-Seq_PC3_Human2.51212046
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.49281042
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49171592
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45692269
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44719564
23CLOCK_20551151_ChIP-Seq_293T_Human2.38532798
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.38525905
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36559953
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.35862496
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.33316517
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28554301
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26559649
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26559649
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.25763598
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25648782
33TCF3_18692474_ChIP-Seq_MESCs_Mouse2.22557539
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.20757315
35EZH2_27304074_Chip-Seq_ESCs_Mouse2.12970087
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10803339
37STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01711209
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00887444
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98548557
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96855846
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96602789
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94147102
43* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93371108
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.91339506
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89207482
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87005156
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85963307
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82774314
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82027341
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.81554584
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79494242
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79471317
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.75030146
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72717213
55NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71575183
56AR_21909140_ChIP-Seq_LNCAP_Human1.70539115
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67803674
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61410852
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.58442831
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57252312
61* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55001941
62* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.53916926
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53307547
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.52319377
65* BRD4_25478319_ChIP-Seq_HGPS_Human1.52292956
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50263372
67TP53_16413492_ChIP-PET_HCT116_Human1.48944249
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.48816545
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.48797280
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48711068
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48250187
72* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47455711
73* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47455711
74TP53_18474530_ChIP-ChIP_U2OS_Human1.46747141
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45721215
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44532009
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44339666
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44188478
79FUS_26573619_Chip-Seq_HEK293_Human1.43143432
80* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42496889
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.42315208
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42204879
83* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41567460
84* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38398311
85AHR_22903824_ChIP-Seq_MCF-7_Human1.38325630
86* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38296255
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.37468825
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36954470
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36365890
90* P300_19829295_ChIP-Seq_ESCs_Human1.35887656
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35481671
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.34998989
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33268334
94* EZH2_27294783_Chip-Seq_ESCs_Mouse1.33243811
95* SOX9_26525672_Chip-Seq_HEART_Mouse1.32805465
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.32685094
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32270749
98* ATF3_27146783_Chip-Seq_COLON_Human1.30908015
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30293176
100* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30188879
101SMAD4_21799915_ChIP-Seq_A2780_Human1.29849485
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29835120
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29730047
104* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29601700
105* CJUN_26792858_Chip-Seq_BT549_Human1.29408980
106* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29165842
107* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27043994
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26903684
109* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26805493
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26441292
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.26389797
112SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25263228
113NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24690008
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23491827
115RXR_22108803_ChIP-Seq_LS180_Human1.22514802
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21765513
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21582587
118ZNF263_19887448_ChIP-Seq_K562_Human1.21509689
119SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21416065
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21041721
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20798975
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20616148
123EWS_26573619_Chip-Seq_HEK293_Human1.20431749
124* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20351935
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19472795
126* UBF1/2_26484160_Chip-Seq_HMECs_Human1.19396463
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17454664
128* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17387944
129NANOG_16153702_ChIP-ChIP_HESCs_Human1.17099004
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16573256
131CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16571689
132RNF2_27304074_Chip-Seq_NSC_Mouse1.15900635
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.15303873
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14964503
135NANOG_21062744_ChIP-ChIP_HESCs_Human1.13963652
136MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13490889
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13474636
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12594955
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12511387
140STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12509959
141* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12448973
142* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12245823
143* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11420462
144NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11022172
145* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10666322
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10482002
147WT1_19549856_ChIP-ChIP_CCG9911_Human1.10118272
148* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09950693
149* GATA1_26923725_Chip-Seq_HPCs_Mouse1.09736875
150* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09421641
151MYC_18555785_ChIP-Seq_MESCs_Mouse1.09230326
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09098808
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08718227
154ELK3_25401928_ChIP-Seq_HUVEC_Human1.08116076
155* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06899245
156OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06100180
157* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03900954
158* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03900954
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03873068
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03526195
161NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03247678
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03247678
163* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02738363
164* NANOG_16518401_ChIP-PET_MESCs_Mouse1.02710386
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02523516
166CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02382348
167RACK7_27058665_Chip-Seq_MCF-7_Human1.02104665
168ISL1_27105846_Chip-Seq_CPCs_Mouse1.01452228
169* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01290579
170* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01261452
171* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01170036
172DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00772687
173AR_19668381_ChIP-Seq_PC3_Human1.00313269
174* STAT3_23295773_ChIP-Seq_U87_Human0.98835898
175CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98103509
176CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96764928
177FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95411919
178HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94330096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.13216806
2MP0003705_abnormal_hypodermis_morpholog3.97501534
3MP0008438_abnormal_cutaneous_collagen3.39797826
4MP0010030_abnormal_orbit_morphology2.85154389
5MP0010352_gastrointestinal_tract_polyps2.47961282
6MP0004272_abnormal_basement_membrane2.47955225
7MP0000372_irregular_coat_pigmentation2.40055454
8MP0005623_abnormal_meninges_morphology2.35377063
9MP0005275_abnormal_skin_tensile2.31137295
10MP0003941_abnormal_skin_development2.28062072
11MP0003566_abnormal_cell_adhesion2.22445720
12MP0003279_aneurysm2.16486217
13MP0005409_darkened_coat_color2.14308136
14MP0005076_abnormal_cell_differentiation2.13917306
15MP0002938_white_spotting2.13785293
16MP0004885_abnormal_endolymph2.09246096
17MP0000569_abnormal_digit_pigmentation1.96509081
18MP0002877_abnormal_melanocyte_morpholog1.90626122
19MP0003283_abnormal_digestive_organ1.84358229
20MP0005408_hypopigmentation1.82811533
21MP0000733_abnormal_muscle_development1.80176131
22MP0005503_abnormal_tendon_morphology1.78487348
23MP0009384_cardiac_valve_regurgitation1.71199848
24MP0005023_abnormal_wound_healing1.70277235
25MP0010368_abnormal_lymphatic_system1.65365220
26MP0009053_abnormal_anal_canal1.60812247
27MP0003091_abnormal_cell_migration1.57828673
28MP0005248_abnormal_Harderian_gland1.52404863
29MP0002089_abnormal_postnatal_growth/wei1.52024289
30MP0005508_abnormal_skeleton_morphology1.51783034
31MP0005257_abnormal_intraocular_pressure1.50757096
32MP0000579_abnormal_nail_morphology1.48393055
33MP0001958_emphysema1.43260220
34MP0002095_abnormal_skin_pigmentation1.41735315
35MP0004197_abnormal_fetal_growth/weight/1.40618160
36MP0002254_reproductive_system_inflammat1.39556924
37MP0001879_abnormal_lymphatic_vessel1.38644463
38MP0000516_abnormal_urinary_system1.38141544
39MP0005367_renal/urinary_system_phenotyp1.38141544
40MP0006292_abnormal_olfactory_placode1.36703318
41MP0000750_abnormal_muscle_regeneration1.36023426
42MP0002653_abnormal_ependyma_morphology1.34389399
43MP0004084_abnormal_cardiac_muscle1.34136531
44MP0001849_ear_inflammation1.32477611
45MP0000778_abnormal_nervous_system1.29927327
46MP0001915_intracranial_hemorrhage1.26829047
47MP0000428_abnormal_craniofacial_morphol1.26694182
48MP0002697_abnormal_eye_size1.26440156
49MP0005197_abnormal_uvea_morphology1.26185535
50MP0000767_abnormal_smooth_muscle1.25907011
51MP0002249_abnormal_larynx_morphology1.25570974
52MP0002084_abnormal_developmental_patter1.25160284
53MP0005174_abnormal_tail_pigmentation1.25095845
54MP0003755_abnormal_palate_morphology1.24390389
55MP0004133_heterotaxia1.23546958
56MP0000432_abnormal_head_morphology1.23449557
57MP0001672_abnormal_embryogenesis/_devel1.22368861
58MP0005380_embryogenesis_phenotype1.22368861
59MP0003119_abnormal_digestive_system1.21671221
60MP0003950_abnormal_plasma_membrane1.20633049
61MP0002108_abnormal_muscle_morphology1.20160157
62MP0002086_abnormal_extraembryonic_tissu1.19003141
63MP0010307_abnormal_tumor_latency1.18758867
64MP0003935_abnormal_craniofacial_develop1.17829222
65MP0002160_abnormal_reproductive_system1.17682986
66MP0003984_embryonic_growth_retardation1.17100996
67MP0002088_abnormal_embryonic_growth/wei1.16763330
68MP0002060_abnormal_skin_morphology1.16486352
69MP0001485_abnormal_pinna_reflex1.15941148
70MP0000015_abnormal_ear_pigmentation1.15428248
71MP0000371_diluted_coat_color1.14556820
72MP0010234_abnormal_vibrissa_follicle1.14429068
73MP0002085_abnormal_embryonic_tissue1.13747301
74MP0009780_abnormal_chondrocyte_physiolo1.13420463
75MP0002925_abnormal_cardiovascular_devel1.13249248
76MP0005171_absent_coat_pigmentation1.12098997
77MP0003937_abnormal_limbs/digits/tail_de1.11994906
78MP0009278_abnormal_bone_marrow1.11671474
79MP0006072_abnormal_retinal_apoptosis1.10614406
80MP0003385_abnormal_body_wall1.10529528
81MP0003115_abnormal_respiratory_system1.09435561
82MP0001293_anophthalmia1.08762693
83MP0010630_abnormal_cardiac_muscle1.08476308
84MP0002896_abnormal_bone_mineralization1.07256858
85MP0003942_abnormal_urinary_system1.06328958
86MP0000049_abnormal_middle_ear1.05485352
87MP0001730_embryonic_growth_arrest1.05322498
88MP0002111_abnormal_tail_morphology1.01621091
89MP0005167_abnormal_blood-brain_barrier1.01371074
90MP0005187_abnormal_penis_morphology1.01094840
91MP0002282_abnormal_trachea_morphology1.00820890
92MP0000350_abnormal_cell_proliferation1.00055613
93MP0003890_abnormal_embryonic-extraembry0.98667676
94MP0002295_abnormal_pulmonary_circulatio0.96802786
95MP0001324_abnormal_eye_pigmentation0.96774274
96MP0002177_abnormal_outer_ear0.96423195
97MP0000762_abnormal_tongue_morphology0.95789190
98MP0004087_abnormal_muscle_fiber0.95345893
99MP0004859_abnormal_synaptic_plasticity0.95300830
100MP0002075_abnormal_coat/hair_pigmentati0.94946210
101MP0009379_abnormal_foot_pigmentation0.94677121
102MP0004858_abnormal_nervous_system0.94530876
103MP0004233_abnormal_muscle_weight0.94346749
104MP0002128_abnormal_blood_circulation0.92757948
105MP0000534_abnormal_ureter_morphology0.92612157
106MP0000163_abnormal_cartilage_morphology0.92571933
107MP0000537_abnormal_urethra_morphology0.92538815
108MP0001697_abnormal_embryo_size0.92393024
109MP0003453_abnormal_keratinocyte_physiol0.92366764
110MP0000026_abnormal_inner_ear0.92340714
111MP0004134_abnormal_chest_morphology0.92228490
112MP0009250_abnormal_appendicular_skeleto0.92012878
113MP0006138_congestive_heart_failure0.91467925
114MP0003828_pulmonary_edema0.91404625
115MP0002092_abnormal_eye_morphology0.91355519
116MP0003861_abnormal_nervous_system0.91123494
117MP0002272_abnormal_nervous_system0.90596252
118MP0005595_abnormal_vascular_smooth0.88825841
119MP0008007_abnormal_cellular_replicative0.87706571
120MP0002233_abnormal_nose_morphology0.87328692
121MP0006054_spinal_hemorrhage0.85785379
122MP0001440_abnormal_grooming_behavior0.85713907
123MP0001299_abnormal_eye_distance/0.85618691
124MP0000266_abnormal_heart_morphology0.85470787
125MP0002269_muscular_atrophy0.85329496
126MP0001614_abnormal_blood_vessel0.85234220
127MP0003045_fibrosis0.84953391
128MP0002932_abnormal_joint_morphology0.84661270
129MP0001286_abnormal_eye_development0.84216038
130MP0000383_abnormal_hair_follicle0.83912707
131MP0002116_abnormal_craniofacial_bone0.83899068
132MP0001486_abnormal_startle_reflex0.83415107
133MP0000566_synostosis0.82655677
134MP0004185_abnormal_adipocyte_glucose0.81561069
135MP0001186_pigmentation_phenotype0.80327592
136MP0005391_vision/eye_phenotype0.77972041
137MP0005253_abnormal_eye_physiology0.76759834
138MP0000631_abnormal_neuroendocrine_gland0.75762521
139MP0003315_abnormal_perineum_morphology0.75691710
140MP0003567_abnormal_fetal_cardiomyocyte0.74973754
141MP0000467_abnormal_esophagus_morphology0.74277144
142MP0005195_abnormal_posterior_eye0.73565160
143MP0000647_abnormal_sebaceous_gland0.73188812
144MP0002102_abnormal_ear_morphology0.72906103
145MP0004270_analgesia0.72729950
146MP0001348_abnormal_lacrimal_gland0.71427532
147MP0002081_perinatal_lethality0.70855871
148MP0002109_abnormal_limb_morphology0.70747346
149MP0001340_abnormal_eyelid_morphology0.70115317

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.06011281
2Premature rupture of membranes (HP:0001788)3.70970436
3Increased connective tissue (HP:0009025)3.47470042
4Aplasia involving bones of the extremities (HP:0009825)3.27308791
5Aplasia involving bones of the upper limbs (HP:0009823)3.27308791
6Aplasia of the phalanges of the hand (HP:0009802)3.27308791
7Abnormality of the middle phalanges of the toes (HP:0010183)3.23808084
8Abnormality of the proximal phalanges of the hand (HP:0009834)3.23582187
9Shallow orbits (HP:0000586)3.18586853
10Ankle contracture (HP:0006466)3.03903995
11Abnormality of the phalanges of the 2nd finger (HP:0009541)2.93625948
12White forelock (HP:0002211)2.82919098
13Cerebral aneurysm (HP:0004944)2.78192984
14Right ventricular cardiomyopathy (HP:0011663)2.75035100
15Atrophic scars (HP:0001075)2.60704967
16Hypoplasia of the ulna (HP:0003022)2.57270012
17Aplasia/Hypoplasia of the fibula (HP:0006492)2.54217895
18Hypoplastic ischia (HP:0003175)2.52390647
19Patchy hypopigmentation of hair (HP:0011365)2.52187857
20Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.51585307
21Selective tooth agenesis (HP:0001592)2.45625137
22Fused cervical vertebrae (HP:0002949)2.41846874
23Fibular hypoplasia (HP:0003038)2.40522748
24Neonatal short-limb short stature (HP:0008921)2.37066557
25Spinal rigidity (HP:0003306)2.36933885
26Cervical subluxation (HP:0003308)2.36830820
27Abnormality of the 2nd finger (HP:0004100)2.36646723
28Urethral obstruction (HP:0000796)2.36198828
29Missing ribs (HP:0000921)2.35936649
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.35168907
31Hypoplasia of the fovea (HP:0007750)2.35168907
32Abnormality of the ischium (HP:0003174)2.33762371
33Rib fusion (HP:0000902)2.32423658
34Short humerus (HP:0005792)2.31550380
35Septo-optic dysplasia (HP:0100842)2.27642797
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26689472
37Broad metatarsal (HP:0001783)2.25113940
38Aortic aneurysm (HP:0004942)2.24222783
39Short femoral neck (HP:0100864)2.24088616
40Conjunctival hamartoma (HP:0100780)2.23254672
41Short hallux (HP:0010109)2.22865463
42Persistence of primary teeth (HP:0006335)2.22412666
43Blue irides (HP:0000635)2.17729992
44Bladder diverticulum (HP:0000015)2.17629471
45Aneurysm (HP:0002617)2.17030509
46Fibular aplasia (HP:0002990)2.16645225
47Anomalous pulmonary venous return (HP:0010772)2.16541824
48Megalencephaly (HP:0001355)2.16328418
49Abnormal auditory evoked potentials (HP:0006958)2.15420863
50Congenital sensorineural hearing impairment (HP:0008527)2.14733382
51Abnormality of the pulmonary veins (HP:0011718)2.13730754
52Aplasia/hypoplasia of the humerus (HP:0006507)2.13618760
53Aplasia/Hypoplasia of the ulna (HP:0006495)2.13569437
54Short 4th metacarpal (HP:0010044)2.13036029
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13036029
56Hamartoma of the eye (HP:0010568)2.12294142
57Difficulty climbing stairs (HP:0003551)2.11335434
58Aplasia/Hypoplasia of the macula (HP:0008059)2.09203299
59Metaphyseal cupping (HP:0003021)2.08895319
60Thin ribs (HP:0000883)2.08515879
61Aplasia/Hypoplasia of the hallux (HP:0008362)2.06627826
62Ulnar bowing (HP:0003031)2.04575411
63Hypopigmentation of the fundus (HP:0007894)2.04430194
64Absent toe (HP:0010760)2.02210884
65Wrist flexion contracture (HP:0001239)2.01473690
66Genu recurvatum (HP:0002816)2.00724632
67Abnormality of the nasal septum (HP:0000419)2.00335132
68Mildly elevated creatine phosphokinase (HP:0008180)1.99660211
69Broad thumb (HP:0011304)1.99320486
70Pseudobulbar signs (HP:0002200)1.98958235
71Meningioma (HP:0002858)1.98953933
72Vertebral fusion (HP:0002948)1.98935378
73Type 1 muscle fiber predominance (HP:0003803)1.98580578
74Hyporeflexia of lower limbs (HP:0002600)1.98205657
75Blue sclerae (HP:0000592)1.96154956
76Vertebral hypoplasia (HP:0008417)1.95690197
77Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.95690197
78Morphological abnormality of the middle ear (HP:0008609)1.95589431
79Aortic dissection (HP:0002647)1.93342692
80Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92799871
81Short 1st metacarpal (HP:0010034)1.92799871
82Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92435327
83Abnormality of the fovea (HP:0000493)1.91733937
84Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91413963
85Abnormality of the 4th metacarpal (HP:0010012)1.91166431
86Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90774023
87Hypoplasia of the iris (HP:0007676)1.88390613
88Skull defect (HP:0001362)1.88204735
89Distal upper limb amyotrophy (HP:0007149)1.87896211
90Upper limb amyotrophy (HP:0009129)1.87896211
91Distal lower limb muscle weakness (HP:0009053)1.87454616
92Mesomelia (HP:0003027)1.87058631
93Myelomeningocele (HP:0002475)1.86927830
94Broad hallux (HP:0010055)1.85104589
95Fragile skin (HP:0001030)1.85031665
96Abnormal number of incisors (HP:0011064)1.84700436
97Broad long bones (HP:0005622)1.84471640
98Wormian bones (HP:0002645)1.84316429
99Soft skin (HP:0000977)1.83938594
100Astrocytoma (HP:0009592)1.83834044
101Abnormality of the astrocytes (HP:0100707)1.83834044
102Abnormality of the phalanges of the 5th finger (HP:0004213)1.83699176
103Hypoplasia of the uterus (HP:0000013)1.83194894
104Abnormality of the frontal sinuses (HP:0002687)1.82575660
105Natal tooth (HP:0000695)1.82561232
106Short nail (HP:0001799)1.82220394
107Oligodontia (HP:0000677)1.82054909
108Ependymoma (HP:0002888)1.80825432
109Synostosis of carpal bones (HP:0005048)1.80804761
110Hypoplastic pelvis (HP:0008839)1.79975137
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.78897728
112Hip contracture (HP:0003273)1.77891252
113Alopecia of scalp (HP:0002293)1.77560217
114Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77548914
115Adactyly (HP:0009776)1.76780054
116Radial bowing (HP:0002986)1.76403167
117Small hand (HP:0200055)1.76255189
118Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.75906263
119Bowing of the arm (HP:0006488)1.75898906
120Bowed forearm bones (HP:0003956)1.75898906
121Cutaneous finger syndactyly (HP:0010554)1.75100247
122Muscle fiber splitting (HP:0003555)1.74895342
123Aortic regurgitation (HP:0001659)1.74829727
124Mitral valve prolapse (HP:0001634)1.74818991
125Scapular winging (HP:0003691)1.74778460
126Esophageal varix (HP:0002040)1.74650207
127Periauricular skin pits (HP:0100277)1.74644700
128Preauricular pit (HP:0004467)1.74644700
129Dilatation of the ascending aorta (HP:0005111)1.74309468
130Camptodactyly of toe (HP:0001836)1.73654093
131Genetic anticipation (HP:0003743)1.72538918
132Abnormality of dentin (HP:0010299)1.72455421
133Preaxial foot polydactyly (HP:0001841)1.72159377
134Vertebral clefting (HP:0008428)1.71686407
135Shawl scrotum (HP:0000049)1.70903800
136Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70397018
137Abnormal vertebral ossification (HP:0100569)1.70326410
138Hand muscle atrophy (HP:0009130)1.69435310
139Carpal synostosis (HP:0009702)1.69311960
140Congenital, generalized hypertrichosis (HP:0004540)1.68893834
141Broad phalanx (HP:0006009)1.68645632
142Back pain (HP:0003418)1.68449413
1432-3 toe syndactyly (HP:0004691)1.68400790
144Esophageal atresia (HP:0002032)1.67783877
145Pterygium (HP:0001059)1.67171690
146Gastrointestinal carcinoma (HP:0002672)1.66802373
147Malignant gastrointestinal tract tumors (HP:0006749)1.66802373
148Abnormality of the calcaneus (HP:0008364)1.66778838
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.66094009
150Tibial bowing (HP:0002982)1.66010551
151Stenosis of the external auditory canal (HP:0000402)1.65756216
152Broad toe (HP:0001837)1.65587120
153Short tibia (HP:0005736)1.65495883
154Broad phalanges of the hand (HP:0009768)1.65479231
155Lymphangioma (HP:0100764)1.63467305
156Chorioretinal atrophy (HP:0000533)1.63450137
157Increased corneal curvature (HP:0100692)1.63281359
158Keratoconus (HP:0000563)1.63281359
159Tarsal synostosis (HP:0008368)1.62851549
160Distal lower limb amyotrophy (HP:0008944)1.62345303
161Benign neoplasm of the central nervous system (HP:0100835)1.61924560
162Coronal craniosynostosis (HP:0004440)1.61647653
163Peritonitis (HP:0002586)1.61567753
164Bowel diverticulosis (HP:0005222)1.61311402
165Anophthalmia (HP:0000528)1.61191812
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.60979337
167Rectal prolapse (HP:0002035)1.60871923
168Aplasia/hypoplasia of the femur (HP:0005613)1.60581122
169Abnormality of the 1st metacarpal (HP:0010009)1.60145903
170Broad finger (HP:0001500)1.58483641
171Glioma (HP:0009733)1.58218901
172Forearm undergrowth (HP:0009821)1.57031871
173Symphalangism affecting the phalanges of the hand (HP:0009773)1.55335465
174Gastrointestinal atresia (HP:0002589)1.55128891
175Progressive cerebellar ataxia (HP:0002073)1.54323924
176Ectopic kidney (HP:0000086)1.53366965
177Cutaneous syndactyly (HP:0012725)1.51678056
178Partial duplication of the phalanx of hand (HP:0009999)1.51528371
179Abnormality of the fibula (HP:0002991)1.49744288
180Limited hip movement (HP:0008800)1.48119355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.76876789
2CDK123.65781809
3TTN2.95721289
4EPHA22.88863674
5TAF12.62592314
6DDR22.61141528
7PDGFRA2.35719615
8STK38L2.23468548
9RIPK12.21909880
10CASK2.18247430
11SIK12.15771133
12LATS22.12338113
13TRIB31.99780579
14NTRK11.81504159
15TNIK1.80260823
16BMX1.74290097
17PNCK1.70058619
18PKN21.68602677
19ICK1.63266214
20PTK61.58788455
21MET1.56879064
22MTOR1.54345591
23EPHB21.53629282
24FGFR21.52098298
25ZAK1.50592514
26PLK21.49636469
27FER1.38448483
28NEK11.35014882
29PAK41.33732910
30NME21.30748814
31STK31.30633772
32RPS6KB21.30459204
33TIE11.29856451
34KDR1.29595114
35TTK1.25769686
36CDK61.25402070
37PTK21.23552860
38SGK2231.21700365
39SGK4941.21700365
40CAMK1D1.18255785
41SGK21.17628160
42ERBB41.17611312
43CDC71.15787740
44TGFBR11.12878795
45VRK21.11569527
46PAK21.09341439
47AKT31.09215122
48MAP3K101.09173507
49BRD41.08351480
50DMPK1.07778631
51BMPR1B1.06791186
52EPHA31.05885616
53FGFR11.03583315
54GRK71.03115620
55CDK71.03090423
56WNK11.03021497
57SGK31.02667560
58CSNK1A1L0.97414723
59NEK20.96232568
60PRKD30.95474379
61GRK50.93113081
62STK100.92411122
63NEK90.91342284
64CSNK1G10.90556226
65LIMK10.90076331
66TYRO30.89320126
67EEF2K0.88537159
68RPS6KA20.88352304
69MARK10.87987040
70RPS6KA40.87175027
71FGFR30.87158061
72ERN10.85460543
73STK380.85457777
74LRRK20.85424306
75MAP3K30.84186735
76TRPM70.83642896
77FRK0.82834982
78MKNK10.81690368
79GRK10.81063546
80CSNK1G20.80821636
81PDGFRB0.80585740
82PRKD20.79146203
83CHUK0.77649574
84LMTK20.77579448
85EPHA40.77396442
86MKNK20.75848119
87WNK40.73575276
88CSNK1G30.73187587
89AURKB0.72991431
90ADRBK10.72024383
91MST1R0.70533914
92PLK10.69606617
93MAPKAPK50.69389615
94PAK30.69381517
95ALK0.69227702
96MAP3K80.68394840
97ROCK10.67245160
98TGFBR20.66734906
99CDC42BPA0.64844694
100PRKCE0.64027958
101MAPKAPK30.63377356
102PDK20.63030180
103DYRK1B0.62881299
104STK390.62737894
105AKT20.62519655
106CAMK2B0.61936852
107CDK80.61728327
108CHEK20.61552554
109CDK40.60457963
110PTK2B0.60440508
111MYLK0.59995425
112PBK0.59110405
113CHEK10.58693484
114ABL20.57837188
115WNK30.57795338
116AURKA0.57276159
117PLK30.57249700
118FGFR40.56548120
119PAK60.56217589
120ATM0.56195598
121GSK3A0.56055428
122MELK0.55812274
123PASK0.54448385
124PRKG20.53668059
125ADRBK20.53035868
126WEE10.52851749
127STK40.52048385
128CAMK2D0.51450211
129PRKCG0.51340634
130SCYL20.50162577
131MOS0.49576950
132NTRK20.49331146
133INSR0.48535331
134ERBB30.47724398
135CSNK1A10.47443386
136ATR0.47053494
137MAPK10.46108878
138CDK20.46056256
139CDK90.46025017
140DYRK30.45906075
141PIM10.45147867
142ERBB20.44680459
143CAMK2A0.44589594
144CAMK1G0.44485608
145NTRK30.44052002
146RPS6KA60.43337316
147AKT10.43068176
148SRPK10.41102631
149FLT30.40455225
150CAMK2G0.40197929
151MARK30.38740767
152PRKAA10.38344491
153PRKDC0.33587242

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.91898718
2ECM-receptor interaction_Homo sapiens_hsa045122.80797220
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24651108
4One carbon pool by folate_Homo sapiens_hsa006702.24476722
5Basal cell carcinoma_Homo sapiens_hsa052172.22682587
6Hippo signaling pathway_Homo sapiens_hsa043902.22473874
7Focal adhesion_Homo sapiens_hsa045102.21098030
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.17890180
9TGF-beta signaling pathway_Homo sapiens_hsa043502.15162891
10Nitrogen metabolism_Homo sapiens_hsa009102.13466121
11MicroRNAs in cancer_Homo sapiens_hsa052062.06121916
12Small cell lung cancer_Homo sapiens_hsa052221.96364967
13Proteoglycans in cancer_Homo sapiens_hsa052051.94017175
14Notch signaling pathway_Homo sapiens_hsa043301.74277577
15Bladder cancer_Homo sapiens_hsa052191.71711340
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70720301
17Nicotine addiction_Homo sapiens_hsa050331.69627557
18Lysine degradation_Homo sapiens_hsa003101.67133695
19Axon guidance_Homo sapiens_hsa043601.58573489
20Tight junction_Homo sapiens_hsa045301.56510288
21Dilated cardiomyopathy_Homo sapiens_hsa054141.55647436
22p53 signaling pathway_Homo sapiens_hsa041151.55333495
23Gastric acid secretion_Homo sapiens_hsa049711.47880898
24Glutamatergic synapse_Homo sapiens_hsa047241.45135787
25Hedgehog signaling pathway_Homo sapiens_hsa043401.39707256
26Amoebiasis_Homo sapiens_hsa051461.34320572
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33525849
28Melanoma_Homo sapiens_hsa052181.32776159
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31209158
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28298973
31Insulin secretion_Homo sapiens_hsa049111.26502802
32Selenocompound metabolism_Homo sapiens_hsa004501.25978071
33Protein digestion and absorption_Homo sapiens_hsa049741.24087062
34RNA transport_Homo sapiens_hsa030131.23252964
35Morphine addiction_Homo sapiens_hsa050321.22782600
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22396267
37Prostate cancer_Homo sapiens_hsa052151.21191982
38Viral myocarditis_Homo sapiens_hsa054161.20604041
39mTOR signaling pathway_Homo sapiens_hsa041501.20395939
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18772433
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.16200111
42Cell cycle_Homo sapiens_hsa041101.14666988
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12443566
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10140690
45Pathways in cancer_Homo sapiens_hsa052001.10109814
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07442111
47Dorso-ventral axis formation_Homo sapiens_hsa043201.06414060
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05089276
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04928341
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04167499
51Circadian entrainment_Homo sapiens_hsa047131.04162665
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03914096
53HIF-1 signaling pathway_Homo sapiens_hsa040661.03862888
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01692207
55Thyroid hormone synthesis_Homo sapiens_hsa049181.01225468
56Gap junction_Homo sapiens_hsa045401.00458677
57Chronic myeloid leukemia_Homo sapiens_hsa052200.99820297
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99363456
59Fatty acid biosynthesis_Homo sapiens_hsa000610.96795333
60HTLV-I infection_Homo sapiens_hsa051660.95752447
61Thyroid cancer_Homo sapiens_hsa052160.94330781
62Malaria_Homo sapiens_hsa051440.92060806
63GABAergic synapse_Homo sapiens_hsa047270.91290559
64Insulin resistance_Homo sapiens_hsa049310.91213551
65Sulfur metabolism_Homo sapiens_hsa009200.90117770
66Salivary secretion_Homo sapiens_hsa049700.87153409
67Cholinergic synapse_Homo sapiens_hsa047250.86884645
68Taste transduction_Homo sapiens_hsa047420.86633954
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86505702
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.85704058
71Cardiac muscle contraction_Homo sapiens_hsa042600.85383591
72Fatty acid degradation_Homo sapiens_hsa000710.85343668
73mRNA surveillance pathway_Homo sapiens_hsa030150.84110884
74Arginine biosynthesis_Homo sapiens_hsa002200.83793643
75Viral carcinogenesis_Homo sapiens_hsa052030.83642997
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82659163
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81850967
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80418919
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80383441
80Rap1 signaling pathway_Homo sapiens_hsa040150.79782302
81Phototransduction_Homo sapiens_hsa047440.78646882
82Wnt signaling pathway_Homo sapiens_hsa043100.78275972
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78169902
84Endometrial cancer_Homo sapiens_hsa052130.77785101
85Biosynthesis of amino acids_Homo sapiens_hsa012300.76181563
86Calcium signaling pathway_Homo sapiens_hsa040200.75722622
87cAMP signaling pathway_Homo sapiens_hsa040240.74899478
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73942679
89Cocaine addiction_Homo sapiens_hsa050300.69318676
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68621925
91Ovarian steroidogenesis_Homo sapiens_hsa049130.68531054
92Basal transcription factors_Homo sapiens_hsa030220.67433441
93Renin secretion_Homo sapiens_hsa049240.66326266
94PPAR signaling pathway_Homo sapiens_hsa033200.66272823
95Serotonergic synapse_Homo sapiens_hsa047260.65733654
96Fatty acid metabolism_Homo sapiens_hsa012120.65672361
97Dopaminergic synapse_Homo sapiens_hsa047280.64100176
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63243374
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62924227
100Oocyte meiosis_Homo sapiens_hsa041140.62529584
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62113630
102Ras signaling pathway_Homo sapiens_hsa040140.62056056
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61765972
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61583774
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61087309
106TNF signaling pathway_Homo sapiens_hsa046680.60007869
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59565046
108Long-term depression_Homo sapiens_hsa047300.59166288
109Starch and sucrose metabolism_Homo sapiens_hsa005000.59048821
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57602202
111AMPK signaling pathway_Homo sapiens_hsa041520.57469422
112Sulfur relay system_Homo sapiens_hsa041220.57301266
113Pancreatic secretion_Homo sapiens_hsa049720.57151764
114Melanogenesis_Homo sapiens_hsa049160.56872898
115Renal cell carcinoma_Homo sapiens_hsa052110.56647037
116Mismatch repair_Homo sapiens_hsa034300.55886603
117Oxytocin signaling pathway_Homo sapiens_hsa049210.55736670
118Toxoplasmosis_Homo sapiens_hsa051450.55176106
119Galactose metabolism_Homo sapiens_hsa000520.53713504
120Bile secretion_Homo sapiens_hsa049760.53498534
121Apoptosis_Homo sapiens_hsa042100.53222965
122Estrogen signaling pathway_Homo sapiens_hsa049150.52475060
123Complement and coagulation cascades_Homo sapiens_hsa046100.52070847
124Arginine and proline metabolism_Homo sapiens_hsa003300.52064162
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.52060772
126Alcoholism_Homo sapiens_hsa050340.51713338
127FoxO signaling pathway_Homo sapiens_hsa040680.51527754
128Legionellosis_Homo sapiens_hsa051340.51452156
129Pancreatic cancer_Homo sapiens_hsa052120.51323135
130Carbon metabolism_Homo sapiens_hsa012000.51130231
131Homologous recombination_Homo sapiens_hsa034400.49823789
132Colorectal cancer_Homo sapiens_hsa052100.48986154
133Vitamin digestion and absorption_Homo sapiens_hsa049770.48574979
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.48433459
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.47538969
136MAPK signaling pathway_Homo sapiens_hsa040100.46621664
137Long-term potentiation_Homo sapiens_hsa047200.46091794
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45634227
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44630740
140Fanconi anemia pathway_Homo sapiens_hsa034600.44233019
141Circadian rhythm_Homo sapiens_hsa047100.43320284
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42596615
143Glioma_Homo sapiens_hsa052140.42154286
144Nucleotide excision repair_Homo sapiens_hsa034200.41703918
145Insulin signaling pathway_Homo sapiens_hsa049100.40704002
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.40277926
147Prion diseases_Homo sapiens_hsa050200.40071515
148RNA degradation_Homo sapiens_hsa030180.39869033
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39833173
150Glucagon signaling pathway_Homo sapiens_hsa049220.39211671
151Spliceosome_Homo sapiens_hsa030400.38285928
152Protein export_Homo sapiens_hsa030600.37308584
153RNA polymerase_Homo sapiens_hsa030200.37085901
154Tryptophan metabolism_Homo sapiens_hsa003800.36861508
155Tyrosine metabolism_Homo sapiens_hsa003500.35254697
156Fructose and mannose metabolism_Homo sapiens_hsa000510.33210350
157Herpes simplex infection_Homo sapiens_hsa051680.32061073
158Systemic lupus erythematosus_Homo sapiens_hsa053220.30562070

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