ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.36722513
2	DNA deamination (GO:0045006)	5.30856817
3	response to pheromone (GO:0019236)	4.47618796
4	protein polyglutamylation (GO:0018095)	4.18984252
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.02666436
6	sperm motility (GO:0030317)	3.71476332
7	axoneme assembly (GO:0035082)	3.69704271
8	piRNA metabolic process (GO:0034587)	3.61990821
9	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.61476125
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56630118
11	tryptophan catabolic process (GO:0006569)	3.55205464
12	indole-containing compound catabolic process (GO:0042436)	3.55205464
13	indolalkylamine catabolic process (GO:0046218)	3.55205464
14	indolalkylamine metabolic process (GO:0006586)	3.53383275
15	epithelial cilium movement (GO:0003351)	3.44130398
16	fucose catabolic process (GO:0019317)	3.42256579
17	L-fucose metabolic process (GO:0042354)	3.42256579
18	L-fucose catabolic process (GO:0042355)	3.42256579
19	negative regulation of telomere maintenance (GO:0032205)	3.41501819
20	kynurenine metabolic process (GO:0070189)	3.37580079
21	platelet dense granule organization (GO:0060155)	3.37126805
22	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.36788606
23	multicellular organism reproduction (GO:0032504)	3.34646329
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.32264342
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.32264342
26	NADH dehydrogenase complex assembly (GO:0010257)	3.32264342
27	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.32027924
28	cellular ketone body metabolic process (GO:0046950)	3.31846684
29	DNA methylation involved in gamete generation (GO:0043046)	3.29790871
30	detection of light stimulus involved in visual perception (GO:0050908)	3.29584220
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.29584220
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.24380546
33	regulation of cilium movement (GO:0003352)	3.21877130
34	somite development (GO:0061053)	3.21722060
35	regulation of action potential (GO:0098900)	3.17337711
36	protein-cofactor linkage (GO:0018065)	3.16517815
37	cilium or flagellum-dependent cell motility (GO:0001539)	3.15070571
38	protein complex biogenesis (GO:0070271)	3.10092911
39	negative regulation of mast cell activation (GO:0033004)	3.08568621
40	rRNA catabolic process (GO:0016075)	3.06877636
41	tryptophan metabolic process (GO:0006568)	3.05007896
42	ketone body metabolic process (GO:1902224)	2.99425587
43	cilium movement (GO:0003341)	2.99262244
44	cAMP catabolic process (GO:0006198)	2.96632006
45	gamma-aminobutyric acid transport (GO:0015812)	2.85080933
46	indole-containing compound metabolic process (GO:0042430)	2.83070267
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.82778239
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82607662
49	regulation of mesoderm development (GO:2000380)	2.79337542
50	neuronal action potential (GO:0019228)	2.79037335
51	primary amino compound metabolic process (GO:1901160)	2.78923810
52	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78304554
53	acrosome reaction (GO:0007340)	2.77000839
54	synaptic transmission, cholinergic (GO:0007271)	2.76028728
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74434634
56	sulfation (GO:0051923)	2.73118821
57	rhodopsin mediated signaling pathway (GO:0016056)	2.70901517
58	mannosylation (GO:0097502)	2.69230043
59	adaptation of signaling pathway (GO:0023058)	2.68864533
60	membrane depolarization during action potential (GO:0086010)	2.66667592
61	spinal cord motor neuron differentiation (GO:0021522)	2.62699229
62	cyclic nucleotide catabolic process (GO:0009214)	2.61988236
63	axonemal dynein complex assembly (GO:0070286)	2.60820391
64	retinal cone cell development (GO:0046549)	2.60291403
65	cell proliferation in forebrain (GO:0021846)	2.60073048
66	GPI anchor metabolic process (GO:0006505)	2.57423241
67	positive regulation of fatty acid transport (GO:2000193)	2.54833860
68	photoreceptor cell development (GO:0042461)	2.53184293
69	regulation of neurotransmitter uptake (GO:0051580)	2.50041057
70	response to lipoprotein particle (GO:0055094)	2.49511694
71	photoreceptor cell maintenance (GO:0045494)	2.48665543
72	centriole replication (GO:0007099)	2.48503902
73	endoderm formation (GO:0001706)	2.47501984
74	male meiosis I (GO:0007141)	2.47472471
75	positive regulation of defense response to virus by host (GO:0002230)	2.47119876
76	cellular response to ATP (GO:0071318)	2.45766527
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.43094497
78	regulation of posttranscriptional gene silencing (GO:0060147)	2.42618573
79	regulation of gene silencing by miRNA (GO:0060964)	2.42618573
80	regulation of gene silencing by RNA (GO:0060966)	2.42618573
81	calcium ion-dependent exocytosis (GO:0017156)	2.42533587
82	behavioral response to ethanol (GO:0048149)	2.42276252
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.42168047
84	NAD biosynthetic process (GO:0009435)	2.42105522
85	transepithelial transport (GO:0070633)	2.41325780
86	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.40794414
87	regulation of hippo signaling (GO:0035330)	2.40088752
88	transmission of nerve impulse (GO:0019226)	2.38829882
89	regulation of microtubule-based movement (GO:0060632)	2.37688213
90	male meiosis (GO:0007140)	2.37477999
91	amine catabolic process (GO:0009310)	2.37038826
92	cellular biogenic amine catabolic process (GO:0042402)	2.37038826
93	double-strand break repair via homologous recombination (GO:0000724)	2.35594347
94	recombinational repair (GO:0000725)	2.35296276
95	nephron tubule morphogenesis (GO:0072078)	2.35070267
96	nephron epithelium morphogenesis (GO:0072088)	2.35070267
97	proline transport (GO:0015824)	2.34963241
98	aromatic amino acid family catabolic process (GO:0009074)	2.34445650
99	nonmotile primary cilium assembly (GO:0035058)	2.34351299
100	protein import into peroxisome matrix (GO:0016558)	2.33002124

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.68681550
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.66491652
3	VDR_22108803_ChIP-Seq_LS180_Human	3.28361019
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.88023103
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29387332
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23861393
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23254597
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17462254
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15325483
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08016266
11	FUS_26573619_Chip-Seq_HEK293_Human	1.93418747
12	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86020357
13	P300_19829295_ChIP-Seq_ESCs_Human	1.83288437
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82239448
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81142263
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.75099495
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.73316202
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73069992
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.69883540
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68184463
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63925736
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63618872
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.63386451
24	EWS_26573619_Chip-Seq_HEK293_Human	1.60373841
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58067508
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.58067508
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55740663
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.50478829
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47624994
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46408462
31	AR_25329375_ChIP-Seq_VCAP_Human	1.44042786
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.43608618
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41272128
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39908517
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38040715
36	* STAT3_23295773_ChIP-Seq_U87_Human	1.37994133
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37615728
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.36618025
39	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34484559
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34263104
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34263104
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33422393
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33200707
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33153925
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32636056
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32548739
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31492045
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31492045
49	TCF4_23295773_ChIP-Seq_U87_Human	1.30668863
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.30251995
51	BCAT_22108803_ChIP-Seq_LS180_Human	1.29229011
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26978570
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26805578
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26355275
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26132902
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.24878860
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24176434
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23740327
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23740327
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22931225
61	NCOR_22424771_ChIP-Seq_293T_Human	1.22752615
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22061870
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21961296
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21365116
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21224826
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.20414780
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.19339753
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19177162
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18942050
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18850180
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18537135
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17981609
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15914627
74	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.15223038
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14186394
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14042651
77	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13329612
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12811940
79	DROSHA_22980978_ChIP-Seq_HELA_Human	1.12012411
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.11023769
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10921820
82	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10716695
83	AR_20517297_ChIP-Seq_VCAP_Human	1.09459160
84	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08180582
85	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07708780
86	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07488558
87	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07334746
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06699232
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06284306
90	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06191935
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06180136
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05161021
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04390097
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03855766
95	ERA_21632823_ChIP-Seq_H3396_Human	1.03510917
96	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03214254
97	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.01031644
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99964655
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99765308
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98607334

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	2.97142601
2	MP0003283_abnormal_digestive_organ	2.81872594
3	MP0002102_abnormal_ear_morphology	2.75673790
4	MP0008877_abnormal_DNA_methylation	2.63230924
5	MP0006292_abnormal_olfactory_placode	2.54030192
6	MP0005551_abnormal_eye_electrophysiolog	2.42763087
7	MP0001968_abnormal_touch/_nociception	2.42535630
8	MP0002876_abnormal_thyroid_physiology	2.29858729
9	MP0005410_abnormal_fertilization	2.25294850
10	MP0004885_abnormal_endolymph	2.21249355
11	MP0002837_dystrophic_cardiac_calcinosis	2.21058237
12	MP0001485_abnormal_pinna_reflex	2.20148264
13	MP0003195_calcinosis	2.19607753
14	MP0003646_muscle_fatigue	2.11464358
15	MP0002736_abnormal_nociception_after	1.94847612
16	MP0005645_abnormal_hypothalamus_physiol	1.91648831
17	MP0002138_abnormal_hepatobiliary_system	1.90212301
18	MP0009745_abnormal_behavioral_response	1.88942367
19	MP0003011_delayed_dark_adaptation	1.87586770
20	MP0003136_yellow_coat_color	1.85954723
21	MP0000631_abnormal_neuroendocrine_gland	1.81248566
22	MP0005377_hearing/vestibular/ear_phenot	1.78523743
23	MP0003878_abnormal_ear_physiology	1.78523743
24	MP0002272_abnormal_nervous_system	1.77657697
25	MP0004142_abnormal_muscle_tone	1.74398173
26	MP0006072_abnormal_retinal_apoptosis	1.73112265
27	MP0009046_muscle_twitch	1.70768109
28	MP0005253_abnormal_eye_physiology	1.64113370
29	MP0001501_abnormal_sleep_pattern	1.62951887
30	MP0005670_abnormal_white_adipose	1.59491606
31	MP0008875_abnormal_xenobiotic_pharmacok	1.58093366
32	MP0008872_abnormal_physiological_respon	1.57660122
33	MP0001986_abnormal_taste_sensitivity	1.54342970
34	MP0003880_abnormal_central_pattern	1.53452993
35	MP0006276_abnormal_autonomic_nervous	1.51782227
36	MP0001486_abnormal_startle_reflex	1.46281100
37	MP0003787_abnormal_imprinting	1.44767840
38	MP0002160_abnormal_reproductive_system	1.42537339
39	MP0002638_abnormal_pupillary_reflex	1.40396228
40	MP0000049_abnormal_middle_ear	1.39428831
41	MP0005389_reproductive_system_phenotype	1.37190898
42	MP0005174_abnormal_tail_pigmentation	1.35677041
43	MP0000569_abnormal_digit_pigmentation	1.34195009
44	MP0004043_abnormal_pH_regulation	1.30903814
45	MP0002735_abnormal_chemical_nociception	1.28403481
46	MP0000372_irregular_coat_pigmentation	1.27996073
47	MP0002064_seizures	1.24465035
48	MP0004133_heterotaxia	1.24437097
49	MP0003119_abnormal_digestive_system	1.24429879
50	MP0002572_abnormal_emotion/affect_behav	1.23976843
51	MP0002653_abnormal_ependyma_morphology	1.23591059
52	MP0004147_increased_porphyrin_level	1.20063117
53	MP0003698_abnormal_male_reproductive	1.17538291
54	MP0003718_maternal_effect	1.15786345
55	MP0002733_abnormal_thermal_nociception	1.15029565
56	MP0000026_abnormal_inner_ear	1.14122205
57	MP0003635_abnormal_synaptic_transmissio	1.12635924
58	MP0002557_abnormal_social/conspecific_i	1.11575343
59	MP0001905_abnormal_dopamine_level	1.11016351
60	MP0002234_abnormal_pharynx_morphology	1.10772045
61	MP0001970_abnormal_pain_threshold	1.10079895
62	MP0001984_abnormal_olfaction	1.09264231
63	MP0001963_abnormal_hearing_physiology	1.08874387
64	MP0002938_white_spotting	1.08550780
65	MP0003879_abnormal_hair_cell	1.06776566
66	MP0004742_abnormal_vestibular_system	1.06715962
67	MP0002067_abnormal_sensory_capabilities	1.05500798
68	MP0001919_abnormal_reproductive_system	1.05489288
69	MP0002277_abnormal_respiratory_mucosa	1.04761552
70	MP0005084_abnormal_gallbladder_morpholo	1.04046149
71	MP0000427_abnormal_hair_cycle	1.03336310
72	MP0002063_abnormal_learning/memory/cond	1.02311890
73	MP0003938_abnormal_ear_development	0.99947117
74	MP0005423_abnormal_somatic_nervous	0.99833967
75	MP0002751_abnormal_autonomic_nervous	0.99011074
76	MP0001929_abnormal_gametogenesis	0.98939272
77	MP0003724_increased_susceptibility_to	0.96253494
78	MP0002229_neurodegeneration	0.95468150
79	MP0005195_abnormal_posterior_eye	0.93443615
80	MP0005367_renal/urinary_system_phenotyp	0.92879901
81	MP0000516_abnormal_urinary_system	0.92879901
82	MP0000013_abnormal_adipose_tissue	0.91525229
83	MP0002928_abnormal_bile_duct	0.88533380
84	MP0000230_abnormal_systemic_arterial	0.86088488
85	MP0001764_abnormal_homeostasis	0.85566712
86	MP0002282_abnormal_trachea_morphology	0.83450601
87	MP0008995_early_reproductive_senescence	0.83194105
88	MP0000383_abnormal_hair_follicle	0.83127394
89	MP0005379_endocrine/exocrine_gland_phen	0.83043618
90	MP0002734_abnormal_mechanical_nocicepti	0.82474230
91	MP0002752_abnormal_somatic_nervous	0.82298771
92	MP0004145_abnormal_muscle_electrophysio	0.82191147
93	MP0001440_abnormal_grooming_behavior	0.81176887
94	MP0005332_abnormal_amino_acid	0.80313759
95	MP0005075_abnormal_melanosome_morpholog	0.79284999
96	MP0002210_abnormal_sex_determination	0.79140096
97	MP0002095_abnormal_skin_pigmentation	0.78572504
98	MP0004130_abnormal_muscle_cell	0.78466933
99	MP0010386_abnormal_urinary_bladder	0.75436397
100	MP0003252_abnormal_bile_duct	0.74957268

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.25604576
2	Congenital stationary night blindness (HP:0007642)	3.92478990
3	Pancreatic fibrosis (HP:0100732)	3.78115400
4	True hermaphroditism (HP:0010459)	3.73103415
5	Nephronophthisis (HP:0000090)	3.71179405
6	Molar tooth sign on MRI (HP:0002419)	3.60883953
7	Abnormality of midbrain morphology (HP:0002418)	3.60883953
8	Attenuation of retinal blood vessels (HP:0007843)	3.32264248
9	Abnormality of the renal medulla (HP:0100957)	3.19015838
10	Type II lissencephaly (HP:0007260)	3.14004084
11	Pendular nystagmus (HP:0012043)	3.10647657
12	Abolished electroretinogram (ERG) (HP:0000550)	3.08054779
13	Chronic hepatic failure (HP:0100626)	3.06552644
14	Abnormality of the renal cortex (HP:0011035)	3.02186582
15	Abnormal drinking behavior (HP:0030082)	2.77297373
16	Polydipsia (HP:0001959)	2.77297373
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.71173776
18	Absent/shortened dynein arms (HP:0200106)	2.68756010
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68756010
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.64446566
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.64446566
22	Clumsiness (HP:0002312)	2.64381718
23	Cystic liver disease (HP:0006706)	2.63037365
24	Increased corneal curvature (HP:0100692)	2.60738753
25	Keratoconus (HP:0000563)	2.60738753
26	Decreased central vision (HP:0007663)	2.58536109
27	Medial flaring of the eyebrow (HP:0010747)	2.51819425
28	Congenital sensorineural hearing impairment (HP:0008527)	2.51574576
29	Methylmalonic acidemia (HP:0002912)	2.51145644
30	Sclerocornea (HP:0000647)	2.50813000
31	Severe visual impairment (HP:0001141)	2.49098600
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.44711660
33	Abnormal ciliary motility (HP:0012262)	2.42666721
34	Bony spicule pigmentary retinopathy (HP:0007737)	2.41468427
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32648751
36	Abnormality of alanine metabolism (HP:0010916)	2.32648751
37	Hyperalaninemia (HP:0003348)	2.32648751
38	Tubular atrophy (HP:0000092)	2.29581688
39	Methylmalonic aciduria (HP:0012120)	2.28774451
40	Progressive cerebellar ataxia (HP:0002073)	2.27415006
41	Genetic anticipation (HP:0003743)	2.24344130
42	Congenital, generalized hypertrichosis (HP:0004540)	2.24076517
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.20546107
44	Decreased circulating renin level (HP:0003351)	2.18154962
45	Chorioretinal atrophy (HP:0000533)	2.15878851
46	Acute necrotizing encephalopathy (HP:0006965)	2.15191484
47	Polyuria (HP:0000103)	2.14853282
48	Renal cortical cysts (HP:0000803)	2.14665545
49	Abnormal respiratory motile cilium physiology (HP:0012261)	2.12890601
50	Gaze-evoked nystagmus (HP:0000640)	2.09378842
51	Cerebellar dysplasia (HP:0007033)	2.08830945
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07162375
53	Mitochondrial inheritance (HP:0001427)	2.05906269
54	Stomach cancer (HP:0012126)	2.04921826
55	Congenital hepatic fibrosis (HP:0002612)	2.02857559
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.02594809
57	Furrowed tongue (HP:0000221)	2.01958081
58	Increased CSF lactate (HP:0002490)	1.98620259
59	Anencephaly (HP:0002323)	1.98421900
60	Severe muscular hypotonia (HP:0006829)	1.98252962
61	Hyperglycinemia (HP:0002154)	1.98055288
62	Inability to walk (HP:0002540)	1.97522233
63	Male pseudohermaphroditism (HP:0000037)	1.96449068
64	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95784014
65	Thyroid-stimulating hormone excess (HP:0002925)	1.92827410
66	Abnormal biliary tract physiology (HP:0012439)	1.92565199
67	Bile duct proliferation (HP:0001408)	1.92565199
68	Abnormality of macular pigmentation (HP:0008002)	1.91302285
69	Acute encephalopathy (HP:0006846)	1.90850006
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90849060
71	Gait imbalance (HP:0002141)	1.90612324
72	Hypoplasia of the pons (HP:0012110)	1.90090925
73	Short tibia (HP:0005736)	1.87802852
74	Optic nerve hypoplasia (HP:0000609)	1.87697904
75	Abnormality of the renal collecting system (HP:0004742)	1.86957160
76	Progressive macrocephaly (HP:0004481)	1.85957316
77	Asplenia (HP:0001746)	1.85619160
78	Short 1st metacarpal (HP:0010034)	1.84281099
79	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.84281099
80	Abnormality of the nasal septum (HP:0000419)	1.84204239
81	Small hand (HP:0200055)	1.83495230
82	Hyperventilation (HP:0002883)	1.82750275
83	3-Methylglutaconic aciduria (HP:0003535)	1.82508927
84	Abnormality of the pons (HP:0007361)	1.82196297
85	Absent thumb (HP:0009777)	1.81813947
86	Retinal dysplasia (HP:0007973)	1.81204611
87	Optic disc pallor (HP:0000543)	1.79726133
88	Congenital primary aphakia (HP:0007707)	1.79495089
89	Abnormal urine output (HP:0012590)	1.78425904
90	Stenosis of the external auditory canal (HP:0000402)	1.74012479
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.73461262
92	Febrile seizures (HP:0002373)	1.72333261
93	Disproportionate short-trunk short stature (HP:0003521)	1.72011828
94	Abnormality of DNA repair (HP:0003254)	1.71607697
95	Postaxial foot polydactyly (HP:0001830)	1.70627443
96	Megalencephaly (HP:0001355)	1.69724158
97	Ketosis (HP:0001946)	1.69711002
98	Aplasia/Hypoplasia of the patella (HP:0006498)	1.68991055
99	Lissencephaly (HP:0001339)	1.66973041
100	IgG deficiency (HP:0004315)	1.65446224

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.98682377
2	TLK1	4.06096739
3	MAP4K2	3.30903792
4	ADRBK2	3.07498855
5	GRK1	2.94307534
6	BMPR1B	2.80074677
7	TAOK3	2.76015889
8	PINK1	2.50074146
9	ZAK	2.30198775
10	WNK3	2.14214768
11	INSRR	2.10896517
12	NUAK1	2.07248856
13	TXK	1.95821237
14	WNK4	1.93852155
15	MAPK13	1.83875794
16	ACVR1B	1.81080121
17	PLK4	1.80240794
18	OXSR1	1.50914383
19	DAPK2	1.43995279
20	PLK2	1.41100468
21	BCKDK	1.31410372
22	STK39	1.26980416
23	MAP3K4	1.26055693
24	PHKG2	1.23999793
25	PHKG1	1.23999793
26	CASK	1.21563923
27	MUSK	1.18861925
28	PNCK	1.15996322
29	NTRK3	1.08073369
30	DYRK2	1.03337652
31	ADRBK1	0.99617952
32	STK38L	0.98583436
33	MARK1	0.97413324
34	PRKCG	0.94890515
35	TNIK	0.93244548
36	EPHA4	0.88210409
37	KIT	0.86688979
38	MAPK15	0.85837695
39	PRKCE	0.82596510
40	IKBKB	0.81663863
41	TIE1	0.81386011
42	PAK3	0.78511836
43	CSNK1G2	0.78323673
44	PTK2B	0.75319270
45	MAP2K7	0.75207609
46	NTRK2	0.74478613
47	CSNK1G3	0.73973830
48	FLT3	0.73032642
49	GRK7	0.69913890
50	VRK1	0.69865332
51	VRK2	0.69422888
52	CAMKK2	0.67715724
53	CSNK1G1	0.67645898
54	TRIM28	0.66412250
55	MAPKAPK5	0.64862759
56	STK16	0.64014619
57	TEC	0.63461991
58	TGFBR1	0.62355073
59	MKNK2	0.61664499
60	ITK	0.61130254
61	MAP2K2	0.61086290
62	NME1	0.57342840
63	PRKCQ	0.55405065
64	PRKACA	0.53904498
65	CDK19	0.53336016
66	PKN1	0.53217878
67	CAMK1	0.52218415
68	PIK3CG	0.51542561
69	CSNK1A1L	0.50745887
70	CSNK1A1	0.50487855
71	MAP3K9	0.50438720
72	RPS6KA5	0.49029732
73	MAP2K1	0.48510744
74	MAPKAPK3	0.48486752
75	TAF1	0.48426751
76	GRK5	0.48388597
77	MAP2K6	0.46902070
78	CAMK2A	0.45965747
79	NEK2	0.45756706
80	TNK2	0.44580957
81	PIK3CA	0.44222607
82	SYK	0.41615056
83	GRK6	0.40963104
84	FGFR2	0.39947322
85	PRKCI	0.37563307
86	PRKCA	0.37496736
87	EIF2AK3	0.37425563
88	EPHA3	0.36082071
89	BUB1	0.34940471
90	PASK	0.34482301
91	RPS6KA6	0.34450905
92	CSNK1D	0.34317009
93	IGF1R	0.32477936
94	STK11	0.32317849
95	PRKCZ	0.32163333
96	SIK2	0.31509012
97	PRKG1	0.31229190
98	SGK494	0.30559662
99	SGK223	0.30559662
100	WNK1	0.29219832

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.92069771
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63623717
3	Nicotine addiction_Homo sapiens_hsa05033	2.45776214
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44335382
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.35579117
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.25377318
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22558341
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.21148806
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18641942
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.15143783
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13848438
12	Butanoate metabolism_Homo sapiens_hsa00650	2.04752357
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03594040
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.92929512
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80448486
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77820418
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.70328491
18	RNA polymerase_Homo sapiens_hsa03020	1.70314051
19	Morphine addiction_Homo sapiens_hsa05032	1.69265037
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64840351
21	Homologous recombination_Homo sapiens_hsa03440	1.61726920
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.56493327
23	Parkinsons disease_Homo sapiens_hsa05012	1.55608862
24	Olfactory transduction_Homo sapiens_hsa04740	1.54550499
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.53772103
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.49644697
27	Taste transduction_Homo sapiens_hsa04742	1.42775192
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40814847
29	Caffeine metabolism_Homo sapiens_hsa00232	1.36598779
30	RNA degradation_Homo sapiens_hsa03018	1.25904988
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.24995964
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24014241
33	Retinol metabolism_Homo sapiens_hsa00830	1.23122960
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22788454
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19829860
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17386039
37	Protein export_Homo sapiens_hsa03060	1.13814847
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12044945
39	Peroxisome_Homo sapiens_hsa04146	1.11950508
40	Basal transcription factors_Homo sapiens_hsa03022	1.11140194
41	Huntingtons disease_Homo sapiens_hsa05016	1.10845446
42	Sulfur metabolism_Homo sapiens_hsa00920	1.09955321
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.09157317
44	Circadian entrainment_Homo sapiens_hsa04713	1.09017035
45	GABAergic synapse_Homo sapiens_hsa04727	1.08964489
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06779142
47	Primary immunodeficiency_Homo sapiens_hsa05340	1.05222215
48	Serotonergic synapse_Homo sapiens_hsa04726	1.03834144
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02157549
50	Alzheimers disease_Homo sapiens_hsa05010	1.01473433
51	ABC transporters_Homo sapiens_hsa02010	1.01249464
52	Asthma_Homo sapiens_hsa05310	1.00711929
53	Glutamatergic synapse_Homo sapiens_hsa04724	1.00073998
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99708815
55	Regulation of autophagy_Homo sapiens_hsa04140	0.99098589
56	Insulin secretion_Homo sapiens_hsa04911	0.97404898
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92328165
58	Propanoate metabolism_Homo sapiens_hsa00640	0.90931550
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90550379
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.87443856
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86334450
62	Sulfur relay system_Homo sapiens_hsa04122	0.83331685
63	One carbon pool by folate_Homo sapiens_hsa00670	0.82340022
64	Purine metabolism_Homo sapiens_hsa00230	0.81984638
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81841429
66	Salivary secretion_Homo sapiens_hsa04970	0.80678629
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.79861097
68	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79137046
69	Allograft rejection_Homo sapiens_hsa05330	0.78200350
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76765431
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.76684963
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75060513
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.72670734
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.72612846
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70993016
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.70368836
77	Metabolic pathways_Homo sapiens_hsa01100	0.62326182
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60275661
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51999913
80	Cholinergic synapse_Homo sapiens_hsa04725	0.50147893
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49783748
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.48342269
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.48230947
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47806283
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47667237
86	Mineral absorption_Homo sapiens_hsa04978	0.46988368
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46931783
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46899084
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46423812
90	Fatty acid degradation_Homo sapiens_hsa00071	0.45425377
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43989448
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43541858
93	Histidine metabolism_Homo sapiens_hsa00340	0.41396332
94	Amphetamine addiction_Homo sapiens_hsa05031	0.39827100
95	Gastric acid secretion_Homo sapiens_hsa04971	0.38974159
96	Renin secretion_Homo sapiens_hsa04924	0.37960686
97	Ribosome_Homo sapiens_hsa03010	0.37949743
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37427769
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36588044
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33552345

MYO15A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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