MYO16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.93879843
2pyrimidine nucleobase catabolic process (GO:0006208)5.82826458
3locomotory exploration behavior (GO:0035641)5.79953261
4vocalization behavior (GO:0071625)5.75969045
5layer formation in cerebral cortex (GO:0021819)5.70722594
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.69878646
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.62077374
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.52486079
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44790239
10neuron cell-cell adhesion (GO:0007158)5.34087550
11protein localization to synapse (GO:0035418)5.13434634
12glutamate secretion (GO:0014047)4.98036052
13regulation of glutamate receptor signaling pathway (GO:1900449)4.95544838
14synaptic vesicle exocytosis (GO:0016079)4.86484281
15nucleobase catabolic process (GO:0046113)4.79847678
16exploration behavior (GO:0035640)4.79804224
17dendritic spine morphogenesis (GO:0060997)4.73380014
18regulation of synapse structural plasticity (GO:0051823)4.66290444
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.64818757
20regulation of synaptic vesicle exocytosis (GO:2000300)4.64288392
21postsynaptic membrane organization (GO:0001941)4.46942268
22gamma-aminobutyric acid transport (GO:0015812)4.33119228
23auditory behavior (GO:0031223)4.27535837
24neurotransmitter-gated ion channel clustering (GO:0072578)4.27330770
25central nervous system projection neuron axonogenesis (GO:0021952)4.23856355
26positive regulation of synapse maturation (GO:0090129)4.22276336
27dendrite morphogenesis (GO:0048813)4.22080952
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.20031184
29neuron recognition (GO:0008038)4.16317613
30axonal fasciculation (GO:0007413)4.11482470
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09743692
32cell migration in hindbrain (GO:0021535)4.07292893
33neurotransmitter secretion (GO:0007269)4.06425426
34regulation of synaptic vesicle transport (GO:1902803)4.03967899
35proline transport (GO:0015824)3.93211153
36regulation of neuronal synaptic plasticity (GO:0048168)3.93003190
37synaptic transmission, glutamatergic (GO:0035249)3.89177953
38response to auditory stimulus (GO:0010996)3.88073331
39behavioral response to nicotine (GO:0035095)3.86924142
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.86788961
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.83993264
42glutamate receptor signaling pathway (GO:0007215)3.81523262
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74687144
44positive regulation of membrane potential (GO:0045838)3.67002954
45regulation of dendritic spine morphogenesis (GO:0061001)3.65251544
46long-term memory (GO:0007616)3.59395517
47establishment of nucleus localization (GO:0040023)3.59230043
48neuron-neuron synaptic transmission (GO:0007270)3.57742369
49presynaptic membrane assembly (GO:0097105)3.57607222
50neuronal ion channel clustering (GO:0045161)3.56435863
51retinal ganglion cell axon guidance (GO:0031290)3.56100172
52cilium movement (GO:0003341)3.48138046
53epithelial cilium movement (GO:0003351)3.47216360
54cerebellar granule cell differentiation (GO:0021707)3.43803463
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43040147
56response to pheromone (GO:0019236)3.41973786
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.41314511
58mitochondrion transport along microtubule (GO:0047497)3.41314511
59cilium or flagellum-dependent cell motility (GO:0001539)3.38629290
60activation of protein kinase A activity (GO:0034199)3.38028374
61negative regulation of microtubule polymerization (GO:0031115)3.37829353
62mechanosensory behavior (GO:0007638)3.36980144
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34702092
64positive regulation of dendritic spine development (GO:0060999)3.34302975
65axon extension (GO:0048675)3.33882925
66presynaptic membrane organization (GO:0097090)3.33014491
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.32852414
68regulation of postsynaptic membrane potential (GO:0060078)3.30592447
69clathrin coat assembly (GO:0048268)3.29232602
70head development (GO:0060322)3.26629591
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26567982
72synapse assembly (GO:0007416)3.26313926
73neuromuscular process controlling balance (GO:0050885)3.26179377
74establishment of mitochondrion localization (GO:0051654)3.25243858
75central nervous system neuron axonogenesis (GO:0021955)3.23354619
76regulation of dendritic spine development (GO:0060998)3.23049872
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22397052
78regulation of synapse maturation (GO:0090128)3.22268951
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20958789
80startle response (GO:0001964)3.19101967
81neuronal action potential propagation (GO:0019227)3.17719434
82calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.17259741
83regulation of neurotransmitter secretion (GO:0046928)3.13670346
84innervation (GO:0060384)3.12368250
85intraciliary transport (GO:0042073)3.11911366
86neurotransmitter transport (GO:0006836)3.11509902
87positive regulation of mitochondrial fission (GO:0090141)3.11380514
88synaptic vesicle endocytosis (GO:0048488)3.11260571
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.10336484
90protein polyglutamylation (GO:0018095)3.09089037
91dendritic spine organization (GO:0097061)3.08741366
92regulation of synaptic plasticity (GO:0048167)3.08309022
93cell communication by electrical coupling (GO:0010644)3.08237368
94intraspecies interaction between organisms (GO:0051703)3.06753840
95social behavior (GO:0035176)3.06753840
96organelle transport along microtubule (GO:0072384)3.06101750
97neurofilament cytoskeleton organization (GO:0060052)3.05272759
98sodium ion export (GO:0071436)3.04777809
99nonmotile primary cilium assembly (GO:0035058)3.04250281
100transmission of nerve impulse (GO:0019226)3.03856896
101neuron projection extension (GO:1990138)3.00989124
102cerebellar Purkinje cell layer development (GO:0021680)3.00072686
103* cerebellum development (GO:0021549)2.99569926
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99525715
105learning (GO:0007612)2.99174532
106cerebellar Purkinje cell differentiation (GO:0021702)2.98193587
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97732967
108positive regulation of neurotransmitter secretion (GO:0001956)2.96983620
109cellular potassium ion homeostasis (GO:0030007)2.96103599
110synapse organization (GO:0050808)2.95706025
111axon cargo transport (GO:0008088)2.95367058
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93060590
113regulation of neurotransmitter levels (GO:0001505)2.90882329
114regulation of synapse organization (GO:0050807)2.89858491
115regulation of axon extension (GO:0030516)2.88857819
116positive regulation of synapse assembly (GO:0051965)2.88667059
117regulation of respiratory system process (GO:0044065)2.87571378
118adult walking behavior (GO:0007628)2.87523707
119protein localization to cilium (GO:0061512)2.86939300
120regulation of vesicle fusion (GO:0031338)2.86026104
121membrane depolarization during action potential (GO:0086010)2.84409117
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.84289182
123glycosphingolipid biosynthetic process (GO:0006688)2.83263567
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77178739
125neuromuscular synaptic transmission (GO:0007274)2.75976521
126cilium assembly (GO:0042384)2.72526829
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72323820
128phosphorelay signal transduction system (GO:0000160)2.70215352
129regulation of cilium movement (GO:0003352)2.67966885
130cilium organization (GO:0044782)2.67101393
131retinal cone cell development (GO:0046549)2.63766312
132retinal rod cell development (GO:0046548)2.55675700
133regulation of microtubule-based movement (GO:0060632)2.53801769
134cytoskeleton-dependent intracellular transport (GO:0030705)2.53438156
135neuron migration (GO:0001764)2.52501767
136detection of light stimulus involved in sensory perception (GO:0050962)2.50426404
137detection of light stimulus involved in visual perception (GO:0050908)2.50426404
138axonogenesis (GO:0007409)2.48638600
139ventricular system development (GO:0021591)2.47908216
140homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.47561542
141microtubule-based transport (GO:0010970)2.47240513
142hippocampus development (GO:0021766)2.46579900
143axonemal dynein complex assembly (GO:0070286)2.45428133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88464855
2GBX2_23144817_ChIP-Seq_PC3_Human3.20254010
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09572845
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01533422
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89293910
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.71201454
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.69854852
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69376086
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69376086
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61500038
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59213885
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53254699
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48763639
14DROSHA_22980978_ChIP-Seq_HELA_Human2.42488334
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42070820
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.41962140
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41904655
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39712431
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39002843
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31201201
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31185218
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.29479281
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.27409809
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22400050
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.22129977
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.20211544
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19378221
28AR_21572438_ChIP-Seq_LNCaP_Human2.14657557
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09555115
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08940961
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02145073
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01358436
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87296997
34VDR_22108803_ChIP-Seq_LS180_Human1.84574507
35FUS_26573619_Chip-Seq_HEK293_Human1.80675614
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78368758
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65545667
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60677604
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.57516762
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54115191
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.51448291
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49061648
43EWS_26573619_Chip-Seq_HEK293_Human1.48037792
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.47534158
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47183717
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45340466
47ZNF274_21170338_ChIP-Seq_K562_Hela1.44772117
48SMAD4_21799915_ChIP-Seq_A2780_Human1.41875759
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40514284
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39631346
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.38930837
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.36816632
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34793884
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.34630765
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32563848
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31827332
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30432709
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30080562
59KDM2B_26808549_Chip-Seq_K562_Human1.27700944
60CBP_20019798_ChIP-Seq_JUKART_Human1.27228214
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27228214
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26803821
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25835402
64AR_19668381_ChIP-Seq_PC3_Human1.25728537
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.25710148
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24889643
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.21518819
68* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21432895
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.21369540
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21362288
71RNF2_27304074_Chip-Seq_NSC_Mouse1.21046900
72TAF15_26573619_Chip-Seq_HEK293_Human1.20467560
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20199036
74ER_23166858_ChIP-Seq_MCF-7_Human1.19561639
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18966664
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.18929366
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18266510
78* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17519104
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17451160
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16796997
81P300_19829295_ChIP-Seq_ESCs_Human1.16402074
82* AR_25329375_ChIP-Seq_VCAP_Human1.15094150
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14576120
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13675357
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13675357
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13358375
87* STAT3_23295773_ChIP-Seq_U87_Human1.13257649
88* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12647437
89TP53_22573176_ChIP-Seq_HFKS_Human1.10249960
90IGF1R_20145208_ChIP-Seq_DFB_Human1.09393554
91* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08287589
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07799283
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07698055
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07393672
95IRF1_19129219_ChIP-ChIP_H3396_Human1.06846666
96* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06216502
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06080333
98JUN_21703547_ChIP-Seq_K562_Human1.05749083
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05506197
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.04909887
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04255531
102* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04192436
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04163519
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03273956
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01826970
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01340163
107SOX9_26525672_Chip-Seq_HEART_Mouse1.01062868
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.00989624
109* AHR_22903824_ChIP-Seq_MCF-7_Human0.98980828
110* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98419522
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98019735
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97790303
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97692865
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.97596065
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97291326
116TCF4_23295773_ChIP-Seq_U87_Human0.96395251
117* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95796275
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95096770
119FLI1_21867929_ChIP-Seq_TH2_Mouse0.95067783
120BCAT_22108803_ChIP-Seq_LS180_Human0.93425798
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91934907
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91766949
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.90264697
124* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88617570
125* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88455727
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87930189
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.87505735
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87385306
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87325998
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87268107
131* RUNX2_22187159_ChIP-Seq_PCA_Human0.86040541
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85964527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.63777398
2MP0004270_analgesia4.04155363
3MP0003635_abnormal_synaptic_transmissio4.01425360
4MP0003880_abnormal_central_pattern3.74107631
5MP0005423_abnormal_somatic_nervous3.57189579
6MP0002063_abnormal_learning/memory/cond3.39065785
7MP0009745_abnormal_behavioral_response3.01173958
8MP0000778_abnormal_nervous_system2.92572405
9MP0002734_abnormal_mechanical_nocicepti2.80607818
10MP0001968_abnormal_touch/_nociception2.77705752
11MP0002064_seizures2.70978952
12MP0002572_abnormal_emotion/affect_behav2.65103451
13MP0009046_muscle_twitch2.56991995
14MP0001486_abnormal_startle_reflex2.47222329
15MP0009780_abnormal_chondrocyte_physiolo2.22434278
16MP0002735_abnormal_chemical_nociception2.20909623
17MP0002184_abnormal_innervation2.15174127
18MP0002736_abnormal_nociception_after2.14286107
19MP0004858_abnormal_nervous_system2.14276121
20MP0004811_abnormal_neuron_physiology2.07743136
21MP0001440_abnormal_grooming_behavior2.02530812
22MP0002733_abnormal_thermal_nociception2.02341564
23MP0002272_abnormal_nervous_system2.00262041
24MP0000569_abnormal_digit_pigmentation1.98544173
25MP0003329_amyloid_beta_deposits1.97051823
26MP0002557_abnormal_social/conspecific_i1.95315622
27MP0000955_abnormal_spinal_cord1.90526338
28MP0005386_behavior/neurological_phenoty1.90001494
29MP0004924_abnormal_behavior1.90001494
30MP0002067_abnormal_sensory_capabilities1.89633514
31MP0001970_abnormal_pain_threshold1.83190468
32MP0003121_genomic_imprinting1.76591555
33MP0008569_lethality_at_weaning1.72420279
34MP0004885_abnormal_endolymph1.66734713
35MP0001529_abnormal_vocalization1.64006508
36MP0002909_abnormal_adrenal_gland1.59422706
37MP0002882_abnormal_neuron_morphology1.59336558
38MP0006276_abnormal_autonomic_nervous1.58189852
39MP0001501_abnormal_sleep_pattern1.57204194
40MP0001485_abnormal_pinna_reflex1.54559794
41MP0003879_abnormal_hair_cell1.50708858
42MP0002152_abnormal_brain_morphology1.47856269
43MP0002066_abnormal_motor_capabilities/c1.42908525
44MP0001984_abnormal_olfaction1.42675200
45MP0008877_abnormal_DNA_methylation1.36524682
46MP0005646_abnormal_pituitary_gland1.35448539
47MP0001986_abnormal_taste_sensitivity1.33029017
48MP0005253_abnormal_eye_physiology1.31778385
49MP0003136_yellow_coat_color1.27438189
50MP0005187_abnormal_penis_morphology1.26751278
51MP0008961_abnormal_basal_metabolism1.26543958
52MP0003787_abnormal_imprinting1.26179705
53MP0002653_abnormal_ependyma_morphology1.20680705
54MP0006072_abnormal_retinal_apoptosis1.20395290
55MP0006292_abnormal_olfactory_placode1.17372182
56MP0003861_abnormal_nervous_system1.17225274
57MP0002102_abnormal_ear_morphology1.15436319
58MP0004133_heterotaxia1.14853476
59MP0002822_catalepsy1.13806718
60MP0000631_abnormal_neuroendocrine_gland1.10989399
61MP0005645_abnormal_hypothalamus_physiol1.09889478
62MP0005394_taste/olfaction_phenotype1.08995561
63MP0005499_abnormal_olfactory_system1.08995561
64MP0001502_abnormal_circadian_rhythm1.04149628
65MP0004147_increased_porphyrin_level1.03885250
66MP0001905_abnormal_dopamine_level1.03170432
67MP0003283_abnormal_digestive_organ1.02923488
68MP0003633_abnormal_nervous_system1.02409387
69MP0000647_abnormal_sebaceous_gland1.00609993
70MP0003631_nervous_system_phenotype0.96588927
71MP0002837_dystrophic_cardiac_calcinosis0.95560402
72MP0003634_abnormal_glial_cell0.94873438
73MP0002069_abnormal_eating/drinking_beha0.94854359
74MP0005195_abnormal_posterior_eye0.93710285
75MP0003137_abnormal_impulse_conducting0.92613367
76MP0004142_abnormal_muscle_tone0.92093075
77MP0002752_abnormal_somatic_nervous0.89854507
78MP0004742_abnormal_vestibular_system0.89330625
79MP0002751_abnormal_autonomic_nervous0.87656560
80MP0002160_abnormal_reproductive_system0.83081248
81MP0003119_abnormal_digestive_system0.83021264
82MP0001348_abnormal_lacrimal_gland0.81934684
83MP0003632_abnormal_nervous_system0.81845357
84MP0001177_atelectasis0.81643597
85MP0003890_abnormal_embryonic-extraembry0.81235698
86MP0002229_neurodegeneration0.79169209
87MP0000604_amyloidosis0.78895726
88MP0003122_maternal_imprinting0.77718514
89MP0000049_abnormal_middle_ear0.77630117
90MP0004233_abnormal_muscle_weight0.77509505
91MP0004085_abnormal_heartbeat0.76799874
92MP0001963_abnormal_hearing_physiology0.76706817
93MP0003646_muscle_fatigue0.75807946
94MP0002938_white_spotting0.75646395
95MP0005171_absent_coat_pigmentation0.75569211
96MP0000751_myopathy0.75338221
97MP0004145_abnormal_muscle_electrophysio0.75226555
98MP0001188_hyperpigmentation0.74204955
99MP0002234_abnormal_pharynx_morphology0.72897547
100MP0005391_vision/eye_phenotype0.72184359
101MP0002928_abnormal_bile_duct0.71626606
102MP0005083_abnormal_biliary_tract0.71413800
103MP0000427_abnormal_hair_cycle0.71114847
104MP0004043_abnormal_pH_regulation0.70917148
105MP0002638_abnormal_pupillary_reflex0.70595093
106MP0000026_abnormal_inner_ear0.69444563
107MP0005551_abnormal_eye_electrophysiolog0.69225279
108MP0002876_abnormal_thyroid_physiology0.69091083
109MP0003938_abnormal_ear_development0.69049511
110MP0008872_abnormal_physiological_respon0.67783965
111MP0008995_early_reproductive_senescence0.67221384
112MP0010386_abnormal_urinary_bladder0.67189565
113MP0005248_abnormal_Harderian_gland0.66887155
114MP0000372_irregular_coat_pigmentation0.66684525
115MP0010770_preweaning_lethality0.65894270
116MP0002082_postnatal_lethality0.65894270
117MP0010769_abnormal_survival0.65591249
118MP0005377_hearing/vestibular/ear_phenot0.65080889
119MP0008789_abnormal_olfactory_epithelium0.64118574
120MP0005623_abnormal_meninges_morphology0.62890867
121MP0001299_abnormal_eye_distance/0.62192831
122MP0002081_perinatal_lethality0.61945156
123MP0010768_mortality/aging0.61317422
124MP0001943_abnormal_respiration0.61175967
125MP0003690_abnormal_glial_cell0.58154775
126MP0003303_peritoneal_inflammation0.57965848
127MP0000537_abnormal_urethra_morphology0.56806453
128MP0001664_abnormal_digestion0.56658822
129MP0000534_abnormal_ureter_morphology0.53226690

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.60561537
2Focal motor seizures (HP:0011153)5.20059382
3Visual hallucinations (HP:0002367)4.58597835
4Focal seizures (HP:0007359)4.50267814
5Epileptic encephalopathy (HP:0200134)4.44729314
6Mutism (HP:0002300)4.30247783
7Supranuclear gaze palsy (HP:0000605)3.76336846
8Broad-based gait (HP:0002136)3.68174217
9Progressive cerebellar ataxia (HP:0002073)3.65710714
10Gait imbalance (HP:0002141)3.62409454
11Amyotrophic lateral sclerosis (HP:0007354)3.59637338
12Pancreatic fibrosis (HP:0100732)3.58233075
13Molar tooth sign on MRI (HP:0002419)3.49588685
14Abnormality of midbrain morphology (HP:0002418)3.49588685
15Poor eye contact (HP:0000817)3.47690677
16Ankle clonus (HP:0011448)3.47618138
17True hermaphroditism (HP:0010459)3.39709649
18Papilledema (HP:0001085)3.38109366
19Medial flaring of the eyebrow (HP:0010747)3.34934102
20Drooling (HP:0002307)3.32606365
21Excessive salivation (HP:0003781)3.32606365
22Chronic hepatic failure (HP:0100626)3.30006308
23Hyperventilation (HP:0002883)3.29976347
24Abnormality of the corticospinal tract (HP:0002492)3.28926189
25Nephronophthisis (HP:0000090)3.28050180
26Pancreatic cysts (HP:0001737)3.15270275
27Congenital primary aphakia (HP:0007707)3.14168093
28Urinary bladder sphincter dysfunction (HP:0002839)3.08249185
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04400347
30Action tremor (HP:0002345)3.03630791
31Febrile seizures (HP:0002373)2.99979407
32Genetic anticipation (HP:0003743)2.99362873
33Nephrogenic diabetes insipidus (HP:0009806)2.98264408
34Abnormal social behavior (HP:0012433)2.98157289
35Impaired social interactions (HP:0000735)2.98157289
36Limb dystonia (HP:0002451)2.94763683
37Akinesia (HP:0002304)2.92152192
38Impaired vibration sensation in the lower limbs (HP:0002166)2.91599865
39Neurofibrillary tangles (HP:0002185)2.88285662
40Cerebral inclusion bodies (HP:0100314)2.87214898
41Urinary urgency (HP:0000012)2.86118160
42Generalized tonic-clonic seizures (HP:0002069)2.85668373
43Megalencephaly (HP:0001355)2.83624904
44Polyphagia (HP:0002591)2.80545115
45Hemiparesis (HP:0001269)2.77978669
46Inappropriate behavior (HP:0000719)2.77685450
47Diplopia (HP:0000651)2.77250016
48Abnormality of binocular vision (HP:0011514)2.77250016
49Absence seizures (HP:0002121)2.75798652
50Obstructive sleep apnea (HP:0002870)2.75493377
51Insidious onset (HP:0003587)2.75095388
52Termporal pattern (HP:0011008)2.75095388
53Genital tract atresia (HP:0001827)2.74982874
54Abnormal eating behavior (HP:0100738)2.73289369
55Atonic seizures (HP:0010819)2.71918069
56Amblyopia (HP:0000646)2.71729145
57Abnormal ciliary motility (HP:0012262)2.71433094
58Progressive inability to walk (HP:0002505)2.64711840
59Abnormality of the renal medulla (HP:0100957)2.63111467
60EEG with generalized epileptiform discharges (HP:0011198)2.62709008
61Epileptiform EEG discharges (HP:0011182)2.62015710
62Vaginal atresia (HP:0000148)2.61158586
63Depression (HP:0000716)2.60832295
64Hypsarrhythmia (HP:0002521)2.60701144
65Torticollis (HP:0000473)2.59066762
66Spastic gait (HP:0002064)2.50986752
67Dialeptic seizures (HP:0011146)2.48200696
68Occipital encephalocele (HP:0002085)2.47961070
69Retinal dysplasia (HP:0007973)2.47823069
70Dysdiadochokinesis (HP:0002075)2.44394127
71Stereotypic behavior (HP:0000733)2.42543692
72Truncal ataxia (HP:0002078)2.42446819
73Gaze-evoked nystagmus (HP:0000640)2.42026212
74Fetal akinesia sequence (HP:0001989)2.41097829
75Apathy (HP:0000741)2.40787293
76Abnormal respiratory motile cilium physiology (HP:0012261)2.38535148
77Hepatoblastoma (HP:0002884)2.38267941
78Inability to walk (HP:0002540)2.35988702
79Abnormality of the lower motor neuron (HP:0002366)2.34913281
80Pachygyria (HP:0001302)2.32763110
81Cortical dysplasia (HP:0002539)2.32277697
82Lower limb muscle weakness (HP:0007340)2.31276929
83Hypoplasia of the brainstem (HP:0002365)2.30470957
84Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30470957
85Insomnia (HP:0100785)2.30390708
86Postaxial foot polydactyly (HP:0001830)2.30132617
87Lissencephaly (HP:0001339)2.28648363
88Focal dystonia (HP:0004373)2.28566462
89Cystic liver disease (HP:0006706)2.28330165
90Tubular atrophy (HP:0000092)2.27750163
91Morphological abnormality of the pyramidal tract (HP:0002062)2.26687193
92Absent speech (HP:0001344)2.25984759
93Poor coordination (HP:0002370)2.25381388
94Aqueductal stenosis (HP:0002410)2.25283219
95Optic nerve hypoplasia (HP:0000609)2.24882500
96Narrow forehead (HP:0000341)2.24729140
97Bony spicule pigmentary retinopathy (HP:0007737)2.24485563
98Abnormality of the labia minora (HP:0012880)2.23394981
99Anencephaly (HP:0002323)2.23373445
100Impaired smooth pursuit (HP:0007772)2.21293982
101Postaxial hand polydactyly (HP:0001162)2.21106890
102Postural instability (HP:0002172)2.20097584
103Anophthalmia (HP:0000528)2.19739570
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.19183419
105Dysmetria (HP:0001310)2.17307552
106Type II lissencephaly (HP:0007260)2.17225995
107Aplasia/Hypoplasia of the tibia (HP:0005772)2.16295739
108Bifid tongue (HP:0010297)2.15374164
109Spastic tetraplegia (HP:0002510)2.13737795
110Diminished motivation (HP:0000745)2.12647557
111Protruding tongue (HP:0010808)2.12540994
112Anxiety (HP:0000739)2.12508682
113Sclerocornea (HP:0000647)2.11738394
114Abnormality of the renal cortex (HP:0011035)2.10591368
115Agitation (HP:0000713)2.07724580
116Craniofacial dystonia (HP:0012179)2.06231601
117Growth hormone deficiency (HP:0000824)2.05385358
118Lower limb amyotrophy (HP:0007210)2.03869869
119Pointed chin (HP:0000307)2.03112083
120Abnormality of salivation (HP:0100755)2.01722844
121Intention tremor (HP:0002080)2.00565001
122Oligodactyly (hands) (HP:0001180)1.98977296
123Abnormal biliary tract physiology (HP:0012439)1.97306467
124Bile duct proliferation (HP:0001408)1.97306467
125Rib fusion (HP:0000902)1.97067659
126Hemiplegia (HP:0002301)1.95286959
127Abnormality of ocular smooth pursuit (HP:0000617)1.95005243
128Sacral dimple (HP:0000960)1.92687215
129Sporadic (HP:0003745)1.92067837
130Bradykinesia (HP:0002067)1.90025242
131Congenital stationary night blindness (HP:0007642)1.88324963
132Scanning speech (HP:0002168)1.88142553
133Tubulointerstitial nephritis (HP:0001970)1.88049356
134Septo-optic dysplasia (HP:0100842)1.87268587
135Neuronal loss in central nervous system (HP:0002529)1.86637002
136Sleep apnea (HP:0010535)1.86067708
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.85302084
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85302084
139Short tibia (HP:0005736)1.85257681
140Abnormal drinking behavior (HP:0030082)1.85213961
141Polydipsia (HP:0001959)1.85213961
142Neoplasm of the adrenal cortex (HP:0100641)1.85071525
143Ankyloglossia (HP:0010296)1.84957420
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83993555
145Congenital hepatic fibrosis (HP:0002612)1.83750831
146Specific learning disability (HP:0001328)1.83143427
147Generalized myoclonic seizures (HP:0002123)1.82442208
148Intellectual disability, profound (HP:0002187)1.82420496
149Abnormal respiratory epithelium morphology (HP:0012253)1.82003371
150Abnormal respiratory motile cilium morphology (HP:0005938)1.82003371
151Broad foot (HP:0001769)1.81768468
152Prominent nasal bridge (HP:0000426)1.81706987
153Hyperglycinemia (HP:0002154)1.81451363
154Rhinitis (HP:0012384)1.80179742
155Aplasia/Hypoplasia of the lens (HP:0008063)1.79787366
156Clonus (HP:0002169)1.79471173
157Hypoplasia of the corpus callosum (HP:0002079)1.79307316
158Failure to thrive in infancy (HP:0001531)1.78920547
159Hyperacusis (HP:0010780)1.78867068
160Impaired vibratory sensation (HP:0002495)1.78511183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.74037928
2MAP3K93.98789194
3MAP4K23.49831902
4NTRK33.01584719
5NTRK22.89637883
6MINK12.73012545
7MAP3K42.69282848
8EPHA42.65257882
9EPHA32.52351719
10FRK2.38373139
11PAK62.30839439
12DAPK22.28364922
13MAP2K72.27275828
14KSR12.16087223
15DYRK22.00719780
16LATS21.96284664
17MAPK131.94512811
18CAMKK11.84925659
19PHKG21.84344521
20PHKG11.84344521
21PINK11.77715162
22KSR21.70522344
23CASK1.61761584
24SIK21.59053578
25TYRO31.58238932
26MAP2K41.45137293
27CDK51.42983002
28NTRK11.35851174
29CSNK1G11.34938533
30PRKD31.34887175
31TRIM281.31859458
32TNIK1.31333807
33ERBB31.28296583
34PLK21.26321511
35CDK191.22882777
36DAPK11.19539743
37PNCK1.14371225
38CAMKK21.14261671
39TAOK11.13682572
40WNK41.10997393
41CSNK1G21.08795152
42MAPK151.05055577
43UHMK11.04923158
44DYRK31.02441634
45CDK180.99779562
46MAP3K120.99499237
47PRKCG0.99049448
48RET0.97578222
49DYRK1A0.97529721
50CDK150.96809848
51CAMK1G0.95064023
52ADRBK20.94988582
53STK110.93895178
54CDK140.91931194
55FGFR20.91281790
56MARK20.87174007
57CDK11A0.85760204
58BMPR1B0.83998514
59GRK50.83908683
60PAK30.81893994
61CCNB10.81576599
62MAP3K60.80797060
63MAP3K20.80208537
64PRKCZ0.77837620
65SCYL20.77759611
66LIMK10.76136347
67STK380.75106272
68STK390.74212383
69STK38L0.73491384
70PKN10.72118609
71BCKDK0.71984052
72ICK0.71441958
73OXSR10.68661567
74ALK0.68154089
75CAMK2A0.67033039
76EPHB20.66991854
77PRPF4B0.65309733
78SGK2230.63670043
79SGK4940.63670043
80MAPK120.58203297
81CAMK10.58067154
82FER0.57254274
83RPS6KA20.56444699
84CSNK1G30.54718873
85CSNK1A1L0.53744590
86SGK10.52578267
87RAF10.52520448
88DYRK1B0.52222746
89PRKACA0.51164079
90BCR0.49340963
91FES0.49291239
92FYN0.48692453
93CSNK1A10.48577692
94PRKCH0.47783767
95PDGFRA0.47460851
96PRKG10.47312550
97MAP2K60.46859181
98PTK2B0.46728866
99GRK10.46481549
100DMPK0.44757745
101INSRR0.43565572
102SIK30.43490011
103ERBB20.43118787
104CDC42BPA0.43017308
105PRKCE0.42911421
106CSNK1E0.42584013
107CAMK1D0.42059803
108RPS6KA30.39853566
109BRD40.39574306
110RPS6KA40.39355483
111MUSK0.38510319
112SGK20.37837527
113PRKACB0.36644742
114ADRBK10.36565289
115CAMK2B0.36403770
116MAPK90.36360065
117CAMK2D0.35930892
118LMTK20.35325064
119BRSK10.34692802
120RIPK40.34397934
121EPHB10.34017542
122RIPK10.33059125
123CDK30.32590419
124WNK30.32465892
125GSK3B0.31365842
126PRKCA0.31068082
127SGK30.30698529
128PDK10.30483104
129TRIB30.30073203
130PDPK10.29718178
131ROCK10.29448085
132MAPK100.28949795
133PRKAA10.28426268
134CSNK1D0.27609112
135CAMK40.27104613

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.30970529
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88080718
3Circadian entrainment_Homo sapiens_hsa047132.49783813
4Glutamatergic synapse_Homo sapiens_hsa047242.46894042
5GABAergic synapse_Homo sapiens_hsa047272.45627119
6Long-term potentiation_Homo sapiens_hsa047202.37896806
7Olfactory transduction_Homo sapiens_hsa047402.37123121
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35658849
9Morphine addiction_Homo sapiens_hsa050322.21713532
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12556105
11Dopaminergic synapse_Homo sapiens_hsa047282.09999039
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02340867
13Amphetamine addiction_Homo sapiens_hsa050312.00515266
14Cholinergic synapse_Homo sapiens_hsa047251.93807802
15Axon guidance_Homo sapiens_hsa043601.91189978
16Salivary secretion_Homo sapiens_hsa049701.83700872
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74370407
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73703831
19Insulin secretion_Homo sapiens_hsa049111.71717382
20Gastric acid secretion_Homo sapiens_hsa049711.66777405
21Long-term depression_Homo sapiens_hsa047301.66591886
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64068144
23Butanoate metabolism_Homo sapiens_hsa006501.59221970
24Oxytocin signaling pathway_Homo sapiens_hsa049211.59130004
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58117409
26Gap junction_Homo sapiens_hsa045401.57279145
27Cocaine addiction_Homo sapiens_hsa050301.53788836
28Renin secretion_Homo sapiens_hsa049241.49301842
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45248529
30Serotonergic synapse_Homo sapiens_hsa047261.44561366
31GnRH signaling pathway_Homo sapiens_hsa049121.43985126
32Glioma_Homo sapiens_hsa052141.41558759
33Caffeine metabolism_Homo sapiens_hsa002321.38405321
34Taste transduction_Homo sapiens_hsa047421.38384338
35Steroid biosynthesis_Homo sapiens_hsa001001.36562999
36Estrogen signaling pathway_Homo sapiens_hsa049151.35505834
37ErbB signaling pathway_Homo sapiens_hsa040121.35302521
38Oxidative phosphorylation_Homo sapiens_hsa001901.29755230
39Type II diabetes mellitus_Homo sapiens_hsa049301.28538237
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28123120
41Calcium signaling pathway_Homo sapiens_hsa040201.25854357
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24756940
43Parkinsons disease_Homo sapiens_hsa050121.22401109
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21696901
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16451535
46Melanogenesis_Homo sapiens_hsa049161.16065140
47Endometrial cancer_Homo sapiens_hsa052131.13970069
48cAMP signaling pathway_Homo sapiens_hsa040241.13698849
49Dorso-ventral axis formation_Homo sapiens_hsa043201.09109317
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07979070
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07368234
52Oocyte meiosis_Homo sapiens_hsa041141.03994722
53Colorectal cancer_Homo sapiens_hsa052101.00833353
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99349333
55Huntingtons disease_Homo sapiens_hsa050160.97776368
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93588129
57Alzheimers disease_Homo sapiens_hsa050100.92970605
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92400026
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91706786
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.91671130
61Renal cell carcinoma_Homo sapiens_hsa052110.91619128
62Pancreatic secretion_Homo sapiens_hsa049720.91411945
63Choline metabolism in cancer_Homo sapiens_hsa052310.90653226
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.89783053
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86976489
66Propanoate metabolism_Homo sapiens_hsa006400.86369941
67VEGF signaling pathway_Homo sapiens_hsa043700.85506743
68mTOR signaling pathway_Homo sapiens_hsa041500.85247246
69Basal transcription factors_Homo sapiens_hsa030220.82081094
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79515108
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78365952
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77880437
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77542104
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76863427
75MAPK signaling pathway_Homo sapiens_hsa040100.76716803
76Phototransduction_Homo sapiens_hsa047440.76365823
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76079929
78Nitrogen metabolism_Homo sapiens_hsa009100.74752880
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.74218782
80Ras signaling pathway_Homo sapiens_hsa040140.72751389
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72520067
82Non-small cell lung cancer_Homo sapiens_hsa052230.71646106
83Regulation of autophagy_Homo sapiens_hsa041400.70742069
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70586059
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70534483
86Wnt signaling pathway_Homo sapiens_hsa043100.69631625
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69453066
88ABC transporters_Homo sapiens_hsa020100.68947970
89Collecting duct acid secretion_Homo sapiens_hsa049660.68500458
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67347475
91Peroxisome_Homo sapiens_hsa041460.67172553
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66120325
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.65579407
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.64143096
95Fatty acid metabolism_Homo sapiens_hsa012120.63098194
96Insulin signaling pathway_Homo sapiens_hsa049100.63002404
97Cardiac muscle contraction_Homo sapiens_hsa042600.62009230
98Rap1 signaling pathway_Homo sapiens_hsa040150.61791203
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.59365934
100Hippo signaling pathway_Homo sapiens_hsa043900.58546260
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57483188
102Thyroid hormone synthesis_Homo sapiens_hsa049180.57079371
103Alcoholism_Homo sapiens_hsa050340.56904702
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55270391
105Ether lipid metabolism_Homo sapiens_hsa005650.54410395
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54410173
107Vibrio cholerae infection_Homo sapiens_hsa051100.53973568
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53864749
109Endocytosis_Homo sapiens_hsa041440.53332082
110Linoleic acid metabolism_Homo sapiens_hsa005910.52285936
111Prion diseases_Homo sapiens_hsa050200.51891519
112Glucagon signaling pathway_Homo sapiens_hsa049220.50931378
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50618603
114Protein export_Homo sapiens_hsa030600.49334785
115Hedgehog signaling pathway_Homo sapiens_hsa043400.47740791
116Bile secretion_Homo sapiens_hsa049760.47693043
117Circadian rhythm_Homo sapiens_hsa047100.47190297
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46940678
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46340684
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45619777
121Pancreatic cancer_Homo sapiens_hsa052120.45483220
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43959499
123Prolactin signaling pathway_Homo sapiens_hsa049170.43398651
124Ovarian steroidogenesis_Homo sapiens_hsa049130.43031353
125Basal cell carcinoma_Homo sapiens_hsa052170.42327385
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42133135
127Fatty acid elongation_Homo sapiens_hsa000620.41115743
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40406068
129AMPK signaling pathway_Homo sapiens_hsa041520.39379439
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.38820326
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38714283
132Lysine degradation_Homo sapiens_hsa003100.38290353
133Inositol phosphate metabolism_Homo sapiens_hsa005620.36895327
134Chemokine signaling pathway_Homo sapiens_hsa040620.36752742
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36407133
136Tryptophan metabolism_Homo sapiens_hsa003800.35551820
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35153626
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34108671
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31228581
140RNA degradation_Homo sapiens_hsa030180.30835520

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