MYO18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)4.35586244
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.24420378
3plasma membrane repair (GO:0001778)4.23717580
4regulation of relaxation of muscle (GO:1901077)4.09439402
5cardiac myofibril assembly (GO:0055003)4.08241888
6negative regulation of potassium ion transmembrane transport (GO:1901380)4.03807738
7negative regulation of erythrocyte differentiation (GO:0045647)3.95286641
8bundle of His cell to Purkinje myocyte communication (GO:0086069)3.87357075
9skeletal muscle adaptation (GO:0043501)3.84104821
10response to inactivity (GO:0014854)3.82658877
11cell communication involved in cardiac conduction (GO:0086065)3.73202671
12ventricular cardiac muscle cell action potential (GO:0086005)3.73120970
13myofibril assembly (GO:0030239)3.71564471
14muscle filament sliding (GO:0030049)3.71488230
15actin-myosin filament sliding (GO:0033275)3.71488230
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.59358755
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57150899
18mannose metabolic process (GO:0006013)3.53733510
19cardiac muscle contraction (GO:0060048)3.46665583
20carnitine shuttle (GO:0006853)3.46010975
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.33904569
22positive regulation of myotube differentiation (GO:0010831)3.32252320
23striated muscle atrophy (GO:0014891)3.29382187
24cell communication by electrical coupling (GO:0010644)3.24361509
25lysine catabolic process (GO:0006554)3.24148863
26lysine metabolic process (GO:0006553)3.24148863
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.17407947
28regulation of skeletal muscle contraction (GO:0014819)3.16935238
29fatty acid transmembrane transport (GO:1902001)3.16142778
30actin-mediated cell contraction (GO:0070252)3.13405920
31response to muscle activity (GO:0014850)3.13217515
32muscle contraction (GO:0006936)3.12914739
33negative regulation of myotube differentiation (GO:0010832)3.09148312
34* actomyosin structure organization (GO:0031032)3.08824183
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.07122212
36skeletal muscle fiber development (GO:0048741)3.03402990
37striated muscle contraction (GO:0006941)3.02915722
38regulation of actin filament-based movement (GO:1903115)3.02051069
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00154706
40regulation of membrane repolarization (GO:0060306)2.92778226
41cardiac muscle hypertrophy (GO:0003300)2.92535380
42glycogen catabolic process (GO:0005980)2.91677440
43NADH metabolic process (GO:0006734)2.90857734
44aspartate family amino acid catabolic process (GO:0009068)2.90228592
45negative regulation of necroptotic process (GO:0060546)2.86789912
46creatine metabolic process (GO:0006600)2.85596848
47muscle system process (GO:0003012)2.85489730
48actin filament-based movement (GO:0030048)2.84088276
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83675071
50striated muscle hypertrophy (GO:0014897)2.80627904
51sarcoplasmic reticulum calcium ion transport (GO:0070296)2.80378932
52cardiac conduction (GO:0061337)2.79776098
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75669449
542-oxoglutarate metabolic process (GO:0006103)2.75633165
55desmosome organization (GO:0002934)2.75558208
56muscle adaptation (GO:0043500)2.74346677
57cell-substrate adherens junction assembly (GO:0007045)2.73950245
58focal adhesion assembly (GO:0048041)2.73950245
59germinal center formation (GO:0002467)2.73199098
60regulation of necroptotic process (GO:0060544)2.73037560
61adult heart development (GO:0007512)2.71915347
62regulation of heart rate by cardiac conduction (GO:0086091)2.71877267
63sodium ion export (GO:0071436)2.69383983
64cellular polysaccharide catabolic process (GO:0044247)2.68529222
65cardiac muscle cell action potential involved in contraction (GO:0086002)2.66746543
66dicarboxylic acid biosynthetic process (GO:0043650)2.65518404
67carnitine transport (GO:0015879)2.64065269
68amino-acid betaine transport (GO:0015838)2.64065269
69carnitine transmembrane transport (GO:1902603)2.63668283
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.62985738
71cardiac muscle cell action potential (GO:0086001)2.62235301
72muscle atrophy (GO:0014889)2.61605848
73cardiac muscle cell development (GO:0055013)2.61423695
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59959149
75muscle tissue morphogenesis (GO:0060415)2.57792245
76positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.54082658
77myotube cell development (GO:0014904)2.54081309
78regulation of striated muscle contraction (GO:0006942)2.52648237
79alpha-linolenic acid metabolic process (GO:0036109)2.52288888
80cellular response to epinephrine stimulus (GO:0071872)2.50910057
81regulation of the force of heart contraction (GO:0002026)2.50175247
82regulation of cholesterol homeostasis (GO:2000188)2.49904474
83regulation of ARF protein signal transduction (GO:0032012)2.48472569
84regulation of p38MAPK cascade (GO:1900744)2.48179467
85potassium ion import (GO:0010107)2.47718746
86cardiac cell development (GO:0055006)2.47687058
87cardiac muscle adaptation (GO:0014887)2.46751273
88cardiac muscle hypertrophy in response to stress (GO:0014898)2.46751273
89muscle hypertrophy in response to stress (GO:0003299)2.46751273
90skeletal muscle tissue development (GO:0007519)2.45822036
91cell-substrate junction assembly (GO:0007044)2.44370167
92regulation of gamma-delta T cell differentiation (GO:0045586)2.44150555
93tricarboxylic acid cycle (GO:0006099)2.43523003
94adherens junction assembly (GO:0034333)2.42830699
95skeletal muscle contraction (GO:0003009)2.42253445
96negative regulation of necrotic cell death (GO:0060547)2.41903962
97activation of protein kinase A activity (GO:0034199)2.40682530
98phospholipid homeostasis (GO:0055091)2.40326453
99regulation of myotube differentiation (GO:0010830)2.39602345
100regulation of fatty acid oxidation (GO:0046320)2.37759409
101cardiac muscle tissue morphogenesis (GO:0055008)2.37758721
102relaxation of cardiac muscle (GO:0055119)2.37224680
103muscle hypertrophy (GO:0014896)2.36850687
104positive regulation of Rap GTPase activity (GO:0032854)2.36104284
105protein localization to endosome (GO:0036010)2.36054823
106heart trabecula formation (GO:0060347)2.35841014
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.35624756
108polysaccharide catabolic process (GO:0000272)2.35333708
109positive regulation of gamma-delta T cell activation (GO:0046645)2.34991761
110membrane tubulation (GO:0097320)2.33360975
111membrane repolarization during action potential (GO:0086011)2.32924999
112regulation of cell communication by electrical coupling (GO:0010649)2.32206235
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32115288
114positive regulation of fatty acid beta-oxidation (GO:0032000)2.31815443
115regulation of calcium ion transmembrane transporter activity (GO:1901019)2.30510765
116regulation of calcium ion transmembrane transport (GO:1903169)2.30510765
117regulation of cardiac muscle cell contraction (GO:0086004)2.30205276
118negative regulation of protein localization to cell surface (GO:2000009)2.29754876
119striated muscle adaptation (GO:0014888)2.29746240
120regulation of myoblast differentiation (GO:0045661)2.29558826
121cellular ketone body metabolic process (GO:0046950)2.29507850
122positive thymic T cell selection (GO:0045059)2.29032035
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28787050
124L-phenylalanine catabolic process (GO:0006559)2.28787050
125regulation of NFAT protein import into nucleus (GO:0051532)2.27035358
126positive regulation of myoblast differentiation (GO:0045663)2.26980486
127cellular hyperosmotic response (GO:0071474)2.26218037
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.25851290
129hemidesmosome assembly (GO:0031581)2.25824904
130regulation of sarcomere organization (GO:0060297)2.25725645
131fatty acid beta-oxidation (GO:0006635)2.25710527
132acetyl-CoA metabolic process (GO:0006084)2.25697904
133regulation of skeletal muscle cell differentiation (GO:2001014)2.23550755
134fructose metabolic process (GO:0006000)2.23521911
135negative regulation of cell size (GO:0045792)2.22959399
136glyoxylate metabolic process (GO:0046487)2.22397405
137regulation of synapse structural plasticity (GO:0051823)2.22376397
138response to mercury ion (GO:0046689)2.21495613
139response to epinephrine (GO:0071871)2.21037635
140regulation of cardioblast differentiation (GO:0051890)2.20841366
141regulation of gamma-delta T cell activation (GO:0046643)2.20534711
142response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.20527231
143response to muramyl dipeptide (GO:0032495)2.20262750
144glucan catabolic process (GO:0009251)2.20208706
145negative regulation of potassium ion transport (GO:0043267)2.20204309
146kynurenine metabolic process (GO:0070189)2.20074389
147regulation of fatty acid beta-oxidation (GO:0031998)2.19662725
148positive regulation of cation channel activity (GO:2001259)2.19065087
149muscle fiber development (GO:0048747)2.18552040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18299209
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.92570364
3VDR_21846776_ChIP-Seq_THP-1_Human2.45892898
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.32236700
5* TCF7_22412390_ChIP-Seq_EML_Mouse2.30007518
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23564977
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23063976
8* LXR_22158963_ChIP-Seq_LIVER_Mouse2.22429382
9MYC_22102868_ChIP-Seq_BL_Human2.12279410
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11655585
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.07246024
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.01609357
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.00489289
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.86523246
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82097241
16* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81948856
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.81918373
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.81762669
19* VDR_24763502_ChIP-Seq_THP-1_Human1.77355848
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70350552
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69343830
22* GATA1_19941827_ChIP-Seq_MEL_Mouse1.68613644
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.65876298
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.65876298
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64441355
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64046529
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60758420
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.55774428
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54929887
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54929887
31EZH2_22144423_ChIP-Seq_EOC_Human1.53044314
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52438052
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50298818
34* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49855044
35* KDM2B_26808549_Chip-Seq_K562_Human1.48572173
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46161792
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.43584010
38* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43537734
39ZNF263_19887448_ChIP-Seq_K562_Human1.43347973
40SCL_19346495_ChIP-Seq_HPC-7_Human1.42333656
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41570800
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38622708
43LXR_22292898_ChIP-Seq_THP-1_Human1.38441106
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38356543
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38317989
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.37707400
47SMC4_20622854_ChIP-Seq_HELA_Human1.37394497
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36783340
49MAF_26560356_Chip-Seq_TH1_Human1.36448299
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36082927
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34165849
52* SPI1_23127762_ChIP-Seq_K562_Human1.33604021
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.32659908
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31669969
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31441191
56* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31329314
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30276145
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29623662
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29113530
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28693992
61KDM2B_26808549_Chip-Seq_DND41_Human1.27820937
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27786530
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26214813
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25346673
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25257297
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24023966
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23783365
68* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23614685
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23418934
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23171060
71* P68_20966046_ChIP-Seq_HELA_Human1.21324422
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21262344
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21006704
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20657172
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20617823
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20067123
77* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20020834
78RUNX_20019798_ChIP-Seq_JUKART_Human1.19939427
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19283852
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.17778341
81CTCF_27219007_Chip-Seq_Bcells_Human1.17509334
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.17414888
83UTX_26944678_Chip-Seq_JUKART_Human1.17082820
84* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16755559
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16586818
86AHR_22903824_ChIP-Seq_MCF-7_Human1.16290323
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.15394200
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.15034118
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13809838
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13581387
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13157301
92CLOCK_20551151_ChIP-Seq_293T_Human1.12399274
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.11170035
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11023409
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10879231
96RACK7_27058665_Chip-Seq_MCF-7_Human1.10844919
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.10701666
98* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09245822
99* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09073663
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08850041
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08101826
102* GATA1_19941826_ChIP-Seq_K562_Human1.08088354
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07432099
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.06910139
105EZH2_27304074_Chip-Seq_ESCs_Mouse1.06536634
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.04771120
107* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04470702
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.03221820
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03161613
110MAF_26560356_Chip-Seq_TH2_Human1.02967377
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02166712
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02070768
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01318544
114* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01195838
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00602282
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.98892933
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.98824804
118EGR1_19374776_ChIP-ChIP_THP-1_Human0.98573348
119* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98509458
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98479352
121* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97959686
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97801420
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97682279
124AR_21572438_ChIP-Seq_LNCaP_Human0.97475302
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.96583286
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95781080
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.95321344
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95233750
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.94522941
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92847183
131* CREB1_26743006_Chip-Seq_LNCaP_Human0.92811479
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.92497755
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90274406
134* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89753807
135TP53_16413492_ChIP-PET_HCT116_Human0.89590394
136* GATA2_19941826_ChIP-Seq_K562_Human0.88688149
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.87063161
138* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87040098
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87032663
140* TP63_22573176_ChIP-Seq_HFKS_Human0.86976298
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.85633078
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84674370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.23814489
2MP0000751_myopathy3.95704823
3MP0004084_abnormal_cardiac_muscle3.51782710
4MP0005360_urolithiasis3.19148843
5MP0004036_abnormal_muscle_relaxation2.89513508
6MP0003646_muscle_fatigue2.81218005
7MP0000749_muscle_degeneration2.76017058
8MP0004215_abnormal_myocardial_fiber2.66921153
9MP0002139_abnormal_hepatobiliary_system2.65360848
10MP0005330_cardiomyopathy2.48706129
11MP0005085_abnormal_gallbladder_physiolo2.44825356
12MP0004087_abnormal_muscle_fiber2.39917431
13MP0004130_abnormal_muscle_cell2.23261655
14MP0003705_abnormal_hypodermis_morpholog2.16287117
15MP0004145_abnormal_muscle_electrophysio2.09651582
16MP0005409_darkened_coat_color2.08368754
17MP0003252_abnormal_bile_duct2.06851410
18MP0004859_abnormal_synaptic_plasticity2.03659905
19MP0000747_muscle_weakness2.01805918
20MP0005365_abnormal_bile_salt1.98526844
21MP0002332_abnormal_exercise_endurance1.97702053
22MP0002972_abnormal_cardiac_muscle1.97073765
23MP0009780_abnormal_chondrocyte_physiolo1.96840663
24MP0005620_abnormal_muscle_contractility1.92294284
25MP0002269_muscular_atrophy1.84143488
26MP0010234_abnormal_vibrissa_follicle1.78942893
27MP0003137_abnormal_impulse_conducting1.78215128
28MP0010630_abnormal_cardiac_muscle1.75968155
29MP0002106_abnormal_muscle_physiology1.73900210
30MP0008775_abnormal_heart_ventricle1.71764078
31MP0006138_congestive_heart_failure1.64587435
32MP0001666_abnormal_nutrient_absorption1.59629237
33MP0004270_analgesia1.56017759
34MP0005083_abnormal_biliary_tract1.55481524
35MP0004085_abnormal_heartbeat1.54962921
36MP0005385_cardiovascular_system_phenoty1.54929134
37MP0001544_abnormal_cardiovascular_syste1.54929134
38MP0008961_abnormal_basal_metabolism1.53823509
39MP0003172_abnormal_lysosome_physiology1.53342705
40MP0005058_abnormal_lysosome_morphology1.48133875
41MP0008875_abnormal_xenobiotic_pharmacok1.47379310
42MP0000750_abnormal_muscle_regeneration1.47244884
43MP0000759_abnormal_skeletal_muscle1.45673567
44MP0004484_altered_response_of1.44208889
45MP0002822_catalepsy1.43030916
46MP0005369_muscle_phenotype1.42102511
47MP0009840_abnormal_foam_cell1.40576330
48MP0010329_abnormal_lipoprotein_level1.38762122
49MP0003329_amyloid_beta_deposits1.36805379
50MP0009278_abnormal_bone_marrow1.36110480
51MP0005666_abnormal_adipose_tissue1.35239887
52MP0002909_abnormal_adrenal_gland1.31517447
53MP0003303_peritoneal_inflammation1.26901399
54MP0003195_calcinosis1.26633247
55MP0004185_abnormal_adipocyte_glucose1.25867787
56MP0005167_abnormal_blood-brain_barrier1.25039176
57MP0005076_abnormal_cell_differentiation1.22327048
58MP0004233_abnormal_muscle_weight1.22068792
59MP0002796_impaired_skin_barrier1.21962574
60MP0003436_decreased_susceptibility_to1.21942069
61MP0004510_myositis1.21298284
62MP0010368_abnormal_lymphatic_system1.18501599
63MP0002234_abnormal_pharynx_morphology1.17070474
64MP0002396_abnormal_hematopoietic_system1.15416553
65MP0004858_abnormal_nervous_system1.13979029
66MP0003191_abnormal_cellular_cholesterol1.12301270
67MP0002118_abnormal_lipid_homeostasis1.11533277
68MP0004043_abnormal_pH_regulation1.09749032
69MP0005451_abnormal_body_composition1.08483937
70MP0005332_abnormal_amino_acid1.07491225
71MP0005375_adipose_tissue_phenotype1.06202858
72MP0003879_abnormal_hair_cell1.06117180
73MP0008260_abnormal_autophagy1.04351388
74MP0000579_abnormal_nail_morphology1.03487125
75MP0004947_skin_inflammation1.01946175
76MP0005670_abnormal_white_adipose1.01604002
77MP0003045_fibrosis1.01586577
78MP0003300_gastrointestinal_ulcer1.01137470
79MP0003566_abnormal_cell_adhesion0.98220014
80MP0003091_abnormal_cell_migration0.97742896
81MP0005464_abnormal_platelet_physiology0.96101090
82MP0000733_abnormal_muscle_development0.92083836
83MP0003283_abnormal_digestive_organ0.91591296
84MP0003690_abnormal_glial_cell0.90904049
85MP0003279_aneurysm0.90169052
86MP0003950_abnormal_plasma_membrane0.89769933
87MP0004381_abnormal_hair_follicle0.88848695
88MP0003635_abnormal_synaptic_transmissio0.88376710
89MP0005623_abnormal_meninges_morphology0.87556635
90MP0003656_abnormal_erythrocyte_physiolo0.87251993
91MP0003453_abnormal_keratinocyte_physiol0.83910394
92MP0010678_abnormal_skin_adnexa0.83390661
93MP0002998_abnormal_bone_remodeling0.82576561
94MP0003221_abnormal_cardiomyocyte_apopto0.82326691
95MP0003763_abnormal_thymus_physiology0.82236027
96MP0000003_abnormal_adipose_tissue0.80689277
97MP0005187_abnormal_penis_morphology0.80569631
98MP0003828_pulmonary_edema0.80023096
99MP0004272_abnormal_basement_membrane0.78846528
100MP0005166_decreased_susceptibility_to0.78266488
101MP0002108_abnormal_muscle_morphology0.75430310
102MP0001958_emphysema0.75064277
103MP0002419_abnormal_innate_immunity0.74889071
104MP0000685_abnormal_immune_system0.74784866
105MP0000604_amyloidosis0.74369522
106MP0002971_abnormal_brown_adipose0.73992444
107MP0001661_extended_life_span0.73662938
108MP0000013_abnormal_adipose_tissue0.72000604
109MP0001765_abnormal_ion_homeostasis0.71088726
110MP0004885_abnormal_endolymph0.70873804
111MP0000230_abnormal_systemic_arterial0.70577381
112MP0002254_reproductive_system_inflammat0.69040829
113MP0008874_decreased_physiological_sensi0.68457306
114MP0001849_ear_inflammation0.67570061
115MP0002127_abnormal_cardiovascular_syste0.67397396
116MP0005025_abnormal_response_to0.67301800
117MP0003183_abnormal_peptide_metabolism0.66982992
118MP0000266_abnormal_heart_morphology0.66980336
119MP0001545_abnormal_hematopoietic_system0.66915984
120MP0005397_hematopoietic_system_phenotyp0.66915984
121MP0003075_altered_response_to0.65701280
122MP0005275_abnormal_skin_tensile0.65694850
123MP0008569_lethality_at_weaning0.65472294
124MP0005584_abnormal_enzyme/coenzyme_acti0.64995293
125MP0009643_abnormal_urine_homeostasis0.64883567
126MP0005319_abnormal_enzyme/_coenzyme0.64842187
127MP0000920_abnormal_myelination0.63972077
128MP0002078_abnormal_glucose_homeostasis0.63579016
129MP0000609_abnormal_liver_physiology0.63071513
130MP0001851_eye_inflammation0.62700210
131MP0005266_abnormal_metabolism0.62668089
132MP0001790_abnormal_immune_system0.60347636
133MP0005387_immune_system_phenotype0.60347636
134MP0002877_abnormal_melanocyte_morpholog0.59876906
135MP0009115_abnormal_fat_cell0.59266462
136MP0002249_abnormal_larynx_morphology0.57812345

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.42602767
2Hyporeflexia of lower limbs (HP:0002600)4.71147815
3Right ventricular cardiomyopathy (HP:0011663)4.55069237
4Exercise-induced myalgia (HP:0003738)4.54048763
5Muscle fiber splitting (HP:0003555)4.17931782
6Ventricular tachycardia (HP:0004756)4.17302649
7Exercise-induced muscle cramps (HP:0003710)3.95243795
8Calf muscle hypertrophy (HP:0008981)3.91608148
9Ulnar deviation of the wrist (HP:0003049)3.67363455
10Muscle hypertrophy of the lower extremities (HP:0008968)3.66932801
11Difficulty running (HP:0009046)3.59775246
12Bundle branch block (HP:0011710)3.51974873
13Abnormality of the calf musculature (HP:0001430)3.49360755
14EMG: myopathic abnormalities (HP:0003458)3.46810725
15Syncope (HP:0001279)3.44976394
16Atrial fibrillation (HP:0005110)3.44059175
17Type 1 muscle fiber predominance (HP:0003803)3.40672020
18Ventricular fibrillation (HP:0001663)3.39636547
19Subaortic stenosis (HP:0001682)3.31337061
20Abnormality of the left ventricular outflow tract (HP:0011103)3.31337061
21Primary atrial arrhythmia (HP:0001692)3.21959328
22Increased connective tissue (HP:0009025)3.21591675
23Prolonged QT interval (HP:0001657)3.19958473
24Myoglobinuria (HP:0002913)3.09008345
25Ventricular arrhythmia (HP:0004308)3.03569695
26Supraventricular tachycardia (HP:0004755)2.99985134
27Supraventricular arrhythmia (HP:0005115)2.99785947
28Asymmetric septal hypertrophy (HP:0001670)2.91992452
29Muscle fiber inclusion bodies (HP:0100299)2.90185124
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.86107158
31Heart block (HP:0012722)2.85781413
32Atrioventricular block (HP:0001678)2.82531808
33Lipoatrophy (HP:0100578)2.78380665
34Abnormal atrioventricular conduction (HP:0005150)2.71143823
35Deep venous thrombosis (HP:0002625)2.70128181
36Mildly elevated creatine phosphokinase (HP:0008180)2.58971610
37Increased variability in muscle fiber diameter (HP:0003557)2.56626101
38Dilated cardiomyopathy (HP:0001644)2.54517217
39Ketoacidosis (HP:0001993)2.52194365
40Difficulty climbing stairs (HP:0003551)2.51599183
41Obstructive sleep apnea (HP:0002870)2.51243278
42Bulbar palsy (HP:0001283)2.47515295
43Ketosis (HP:0001946)2.43355507
44Abnormality of skeletal muscle fiber size (HP:0012084)2.42664748
45Calcaneovalgus deformity (HP:0001848)2.38369059
46Palpitations (HP:0001962)2.37606542
47Malignant hyperthermia (HP:0002047)2.37286332
48Rimmed vacuoles (HP:0003805)2.34798512
49Distal lower limb amyotrophy (HP:0008944)2.32750598
50Myotonia (HP:0002486)2.32545417
51Nemaline bodies (HP:0003798)2.29451473
52Xanthomatosis (HP:0000991)2.28388127
53EMG: neuropathic changes (HP:0003445)2.26695630
54Abnormal EKG (HP:0003115)2.26029552
55Lower limb amyotrophy (HP:0007210)2.25144312
56Scapular winging (HP:0003691)2.24256590
57Round ear (HP:0100830)2.21552159
58Areflexia of lower limbs (HP:0002522)2.20359508
59Hypoglycemic coma (HP:0001325)2.15504186
60Lymphangioma (HP:0100764)2.14362779
61Intrahepatic cholestasis (HP:0001406)2.12937275
62Dysmetric saccades (HP:0000641)2.12287368
63Frequent falls (HP:0002359)2.06825814
64Gout (HP:0001997)2.03343886
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.00731810
66Broad metatarsal (HP:0001783)2.00063532
67Absent phalangeal crease (HP:0006109)1.98879744
68Gowers sign (HP:0003391)1.97115511
69Deformed tarsal bones (HP:0008119)1.96860505
70Hyperkalemia (HP:0002153)1.95698484
71Distal lower limb muscle weakness (HP:0009053)1.92979436
72Sudden cardiac death (HP:0001645)1.92083792
73Muscle stiffness (HP:0003552)1.88843602
74Easy fatigability (HP:0003388)1.87317977
75Abnormality of the calcaneus (HP:0008364)1.86515259
76Hyperinsulinemic hypoglycemia (HP:0000825)1.86216125
77Limb-girdle muscle atrophy (HP:0003797)1.86001442
78Facial diplegia (HP:0001349)1.85397453
79Hypoalphalipoproteinemia (HP:0003233)1.84817586
80Cholelithiasis (HP:0001081)1.84710590
81Generalized muscle weakness (HP:0003324)1.82638995
82Neck muscle weakness (HP:0000467)1.82569035
83Myopathic facies (HP:0002058)1.82233302
84Hyperammonemia (HP:0001987)1.82122994
85Rhabdomyolysis (HP:0003201)1.81794002
86Distal upper limb amyotrophy (HP:0007149)1.81278422
87Upper limb amyotrophy (HP:0009129)1.81278422
88Hypoplastic ischia (HP:0003175)1.81247101
89Hamartoma of the eye (HP:0010568)1.80312713
90Abnormality of the foot musculature (HP:0001436)1.78866791
91Distal arthrogryposis (HP:0005684)1.76203570
92Slender build (HP:0001533)1.75425351
93Foot dorsiflexor weakness (HP:0009027)1.74564754
94Spinal rigidity (HP:0003306)1.73891967
95Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73776542
96Rapidly progressive (HP:0003678)1.73460094
97Weak cry (HP:0001612)1.73022144
98Abnormality of the Achilles tendon (HP:0005109)1.72890917
99Cerebral aneurysm (HP:0004944)1.71241804
100Broad face (HP:0000283)1.69157350
101Ragged-red muscle fibers (HP:0003200)1.68824256
102Abnormal gallbladder morphology (HP:0012437)1.66106757
103Abnormality of the ischium (HP:0003174)1.65175938
104Cerebral inclusion bodies (HP:0100314)1.65160141
105Palmoplantar keratoderma (HP:0000982)1.64764235
106Progressive muscle weakness (HP:0003323)1.64022465
107Fatigable weakness (HP:0003473)1.63569083
108Abnormality of the neuromuscular junction (HP:0003398)1.63569083
109Hip contracture (HP:0003273)1.63120813
110Skin nodule (HP:0200036)1.62948931
111Hyperacusis (HP:0010780)1.61813143
112Epidermoid cyst (HP:0200040)1.61106769
113Onion bulb formation (HP:0003383)1.59389589
114Achilles tendon contracture (HP:0001771)1.59222934
115Myokymia (HP:0002411)1.58884562
116Waddling gait (HP:0002515)1.58604666
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58525071
118Visceral angiomatosis (HP:0100761)1.57883953
119Complement deficiency (HP:0004431)1.57773256
120Late onset (HP:0003584)1.57656187
121Fetal akinesia sequence (HP:0001989)1.57088147
122Ankle clonus (HP:0011448)1.56651234
123Hyperglycinuria (HP:0003108)1.56249026
124Increased IgE level (HP:0003212)1.56141384
125Abnormality of the fingertips (HP:0001211)1.55941955
126Stridor (HP:0010307)1.55867294
127Abnormal finger flexion creases (HP:0006143)1.54257061
128Aneurysm (HP:0002617)1.50257292
129Colitis (HP:0002583)1.49471757
130Hemorrhage of the eye (HP:0011885)1.47874401
131Abnormality of complement system (HP:0005339)1.47508828
132Eczematoid dermatitis (HP:0000976)1.47318008
133Muscular dystrophy (HP:0003560)1.43941787
134Cellulitis (HP:0100658)1.40591337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.38379359
2TTN3.11852853
3OBSCN2.75999285
4PKN22.66681203
5LMTK22.64942955
6PRPF4B2.63742838
7PHKG22.57248013
8PHKG12.57248013
9RIPK12.19362288
10DMPK2.08075194
11MAP2K31.99389617
12CDK121.83313245
13SIK11.76284497
14EPHB11.74364676
15MAP3K71.72746319
16MAP3K131.65797065
17PTK61.65274852
18EPHA41.53103282
19PAK61.51435418
20ICK1.49171147
21PDGFRA1.46216848
22PRKD31.41708472
23PAK31.36655274
24RIPK41.35915999
25DAPK21.28022496
26WNK41.21824227
27MAP4K11.18788905
28TRPM71.17446685
29TIE11.16227000
30MAP3K91.15791232
31BCKDK1.14738510
32MAP3K101.13885340
33ERN11.12076930
34TNK21.11001261
35INSRR1.10357796
36EPHB21.09881908
37FGFR41.09480649
38SMG11.09232512
39PRKD11.09081372
40CAMK1G1.07846312
41PIK3CA1.07664893
42KSR21.07608279
43ZAP701.03663261
44MAP3K61.03067832
45MAPK71.00060559
46TYRO30.98864241
47CDC42BPA0.98096962
48STK380.97969576
49CAMKK10.97908129
50RET0.97317008
51PRKCH0.97095360
52PKN10.94873774
53TAOK10.94616736
54MYLK0.93597666
55NTRK10.93411252
56FER0.93132733
57ROCK10.92815280
58MAP3K20.92374650
59MAPK110.92358337
60MARK10.89861041
61SGK30.88200872
62WNK10.87861532
63MAPK120.87273470
64FGFR20.87014155
65TBK10.86174969
66CAMK1D0.85720593
67BLK0.85089850
68FES0.84947889
69PDK30.83569209
70PDK40.83569209
71MAP2K40.83232593
72SIK20.83199640
73LATS10.82536967
74PDPK10.82479662
75MARK20.80078001
76PRKAA10.79545054
77PINK10.79341479
78STK390.79273598
79MUSK0.78588245
80PRKAA20.78385959
81PTK20.78202660
82STK110.77693252
83MAPKAPK30.74989277
84NEK10.73697249
85MAP2K60.73380532
86RPS6KA20.73188819
87MOS0.72518200
88PDGFRB0.71698310
89DYRK1B0.68293796
90HIPK20.67975673
91NTRK30.67132101
92CSF1R0.66595497
93CDK50.65969186
94ROCK20.65693557
95ERBB20.65346341
96TYK20.65335488
97MAP3K10.64419791
98MAPK40.64257689
99PTK2B0.63762485
100RPS6KC10.63299268
101RPS6KL10.63299268
102OXSR10.62593171
103MTOR0.62564258
104MAP3K30.62502581
105CAMK40.62268268
106PDK10.62116757
107CAMK2D0.61398588
108BMX0.60543076
109SGK2230.60369756
110SGK4940.60369756
111BTK0.59501618
112UHMK10.57761722
113NEK90.57345497
114SYK0.57315474
115MAP3K40.56794018
116EEF2K0.56266291
117SGK20.55901119
118MAP3K110.55741399
119MAP2K10.55224762
120CAMK10.53797601
121MET0.52754469
122HCK0.51782865
123SGK10.51549807
124ILK0.50466680
125ALK0.50220803
126NTRK20.49650612
127PIK3CG0.49328921
128MAPK100.49266482
129DAPK30.49150119
130JAK10.48937129
131MAP3K140.48299449
132PRKD20.47901702
133FGFR30.47355961
134TGFBR20.47299893
135RPS6KA60.46307567
136JAK20.46117716
137KIT0.46088386
138LATS20.45810935
139MST1R0.44584096
140CAMK2G0.43655583
141IRAK30.43307306
142TAOK20.40712669
143MAP2K20.40397732
144ITK0.38621021

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.86935269
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78672893
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21814242
4Fatty acid degradation_Homo sapiens_hsa000712.06950141
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05476843
6Dilated cardiomyopathy_Homo sapiens_hsa054142.03190426
7Arginine biosynthesis_Homo sapiens_hsa002201.98088101
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85069111
9Other glycan degradation_Homo sapiens_hsa005111.81924823
10Propanoate metabolism_Homo sapiens_hsa006401.66015984
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65314169
12Fatty acid metabolism_Homo sapiens_hsa012121.65302388
13Bile secretion_Homo sapiens_hsa049761.64659899
14Butanoate metabolism_Homo sapiens_hsa006501.63903409
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59336434
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.54238486
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47590192
18PPAR signaling pathway_Homo sapiens_hsa033201.45490947
19Tryptophan metabolism_Homo sapiens_hsa003801.42128847
20Acute myeloid leukemia_Homo sapiens_hsa052211.39332234
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38113408
22Cardiac muscle contraction_Homo sapiens_hsa042601.37927283
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36365627
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29621397
25B cell receptor signaling pathway_Homo sapiens_hsa046621.28100926
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24255092
27Starch and sucrose metabolism_Homo sapiens_hsa005001.22055555
28Fat digestion and absorption_Homo sapiens_hsa049751.20450439
29Lysine degradation_Homo sapiens_hsa003101.17283151
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14803016
31Non-small cell lung cancer_Homo sapiens_hsa052231.13527534
32Gastric acid secretion_Homo sapiens_hsa049711.11769133
33Chronic myeloid leukemia_Homo sapiens_hsa052201.10451442
34Fructose and mannose metabolism_Homo sapiens_hsa000511.10364826
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08205211
36Pentose phosphate pathway_Homo sapiens_hsa000301.06932614
37Platelet activation_Homo sapiens_hsa046111.06378726
38Insulin resistance_Homo sapiens_hsa049311.05820000
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05623097
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05373767
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05124490
42Carbon metabolism_Homo sapiens_hsa012001.04307144
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.00735340
44Type II diabetes mellitus_Homo sapiens_hsa049301.00405411
45Prion diseases_Homo sapiens_hsa050201.00237926
46mTOR signaling pathway_Homo sapiens_hsa041500.97656192
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96910636
48Osteoclast differentiation_Homo sapiens_hsa043800.93980601
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.93315972
50ABC transporters_Homo sapiens_hsa020100.92349060
51Notch signaling pathway_Homo sapiens_hsa043300.91787200
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91773679
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90427317
54Insulin secretion_Homo sapiens_hsa049110.89202469
55Pyruvate metabolism_Homo sapiens_hsa006200.87296916
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85926449
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85644209
58Circadian rhythm_Homo sapiens_hsa047100.85231547
59ErbB signaling pathway_Homo sapiens_hsa040120.85043922
60Staphylococcus aureus infection_Homo sapiens_hsa051500.84805464
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.83731081
62Oxytocin signaling pathway_Homo sapiens_hsa049210.83650446
63Renin secretion_Homo sapiens_hsa049240.83106307
64Salivary secretion_Homo sapiens_hsa049700.82894278
65Endometrial cancer_Homo sapiens_hsa052130.82705829
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82111775
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.82085390
68Glucagon signaling pathway_Homo sapiens_hsa049220.82082086
69beta-Alanine metabolism_Homo sapiens_hsa004100.81270080
70Caffeine metabolism_Homo sapiens_hsa002320.81210673
71Circadian entrainment_Homo sapiens_hsa047130.81199345
72Complement and coagulation cascades_Homo sapiens_hsa046100.79860741
73Inositol phosphate metabolism_Homo sapiens_hsa005620.79624372
74Dorso-ventral axis formation_Homo sapiens_hsa043200.79471469
75Choline metabolism in cancer_Homo sapiens_hsa052310.78033101
76Tight junction_Homo sapiens_hsa045300.77618477
77Leishmaniasis_Homo sapiens_hsa051400.75306505
78Pancreatic cancer_Homo sapiens_hsa052120.75204619
79Focal adhesion_Homo sapiens_hsa045100.74725442
80Insulin signaling pathway_Homo sapiens_hsa049100.73770313
81Fatty acid biosynthesis_Homo sapiens_hsa000610.71153844
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71045512
83Fatty acid elongation_Homo sapiens_hsa000620.69406039
84MAPK signaling pathway_Homo sapiens_hsa040100.69297980
85T cell receptor signaling pathway_Homo sapiens_hsa046600.68001312
86Prolactin signaling pathway_Homo sapiens_hsa049170.67204974
87Calcium signaling pathway_Homo sapiens_hsa040200.66999905
88GnRH signaling pathway_Homo sapiens_hsa049120.66776602
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.65314034
90Pancreatic secretion_Homo sapiens_hsa049720.63874422
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63640361
92Axon guidance_Homo sapiens_hsa043600.63390662
93Toxoplasmosis_Homo sapiens_hsa051450.63230604
94Peroxisome_Homo sapiens_hsa041460.62147712
95GABAergic synapse_Homo sapiens_hsa047270.61519473
96FoxO signaling pathway_Homo sapiens_hsa040680.61456041
97Glutamatergic synapse_Homo sapiens_hsa047240.60698831
98cAMP signaling pathway_Homo sapiens_hsa040240.60315967
99Biosynthesis of amino acids_Homo sapiens_hsa012300.60294576
100Galactose metabolism_Homo sapiens_hsa000520.59971971
101Cholinergic synapse_Homo sapiens_hsa047250.59658884
102Protein digestion and absorption_Homo sapiens_hsa049740.59493851
103Olfactory transduction_Homo sapiens_hsa047400.59297753
104AMPK signaling pathway_Homo sapiens_hsa041520.59059591
105Glycerolipid metabolism_Homo sapiens_hsa005610.58222607
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57543865
107HIF-1 signaling pathway_Homo sapiens_hsa040660.56262255
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56142918
109Gap junction_Homo sapiens_hsa045400.56092833
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56070382
111ECM-receptor interaction_Homo sapiens_hsa045120.56065115
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55517034
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55239271
114Tuberculosis_Homo sapiens_hsa051520.54217521
115Long-term potentiation_Homo sapiens_hsa047200.54012360
116Amoebiasis_Homo sapiens_hsa051460.53109868
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52467108
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51925495
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.51913795
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51522285
121Estrogen signaling pathway_Homo sapiens_hsa049150.51355678
122Long-term depression_Homo sapiens_hsa047300.51150554
123Sulfur metabolism_Homo sapiens_hsa009200.50622897
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50578896
125Histidine metabolism_Homo sapiens_hsa003400.50377773
126Phenylalanine metabolism_Homo sapiens_hsa003600.49419645
127Arginine and proline metabolism_Homo sapiens_hsa003300.48683470
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48509427
129Pertussis_Homo sapiens_hsa051330.48397070
130Viral myocarditis_Homo sapiens_hsa054160.47986666
131VEGF signaling pathway_Homo sapiens_hsa043700.47826005
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47721604
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47499585
134Adherens junction_Homo sapiens_hsa045200.47299202
135Glioma_Homo sapiens_hsa052140.46997931
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44920187
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.44571577
138Morphine addiction_Homo sapiens_hsa050320.44049962
139Proteoglycans in cancer_Homo sapiens_hsa052050.43037517
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42519936
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42263030
142Renal cell carcinoma_Homo sapiens_hsa052110.40711594

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