MYO18B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.71946742
2actin-myosin filament sliding (GO:0033275)8.73798012
3muscle filament sliding (GO:0030049)8.73798012
4cardiac myofibril assembly (GO:0055003)8.38480355
5myofibril assembly (GO:0030239)8.09569826
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.87597695
7regulation of skeletal muscle contraction (GO:0014819)7.48365958
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.35469857
9actin-mediated cell contraction (GO:0070252)7.21151451
10negative regulation of potassium ion transmembrane transport (GO:1901380)7.08321824
11plasma membrane repair (GO:0001778)7.05847426
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.79208896
13cardiac muscle contraction (GO:0060048)6.71933600
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.54551054
15cardiac muscle cell development (GO:0055013)6.48475181
16sarcoplasmic reticulum calcium ion transport (GO:0070296)6.32401614
17actomyosin structure organization (GO:0031032)6.17396496
18cardiac cell development (GO:0055006)6.09165831
19striated muscle contraction (GO:0006941)5.94181865
20regulation of relaxation of muscle (GO:1901077)5.87527957
21regulation of actin filament-based movement (GO:1903115)5.83753460
22adult heart development (GO:0007512)5.78500600
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.75758715
24cardiac muscle tissue morphogenesis (GO:0055008)5.64705460
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.63144462
26ventricular cardiac muscle cell action potential (GO:0086005)5.60233414
27carnitine shuttle (GO:0006853)5.54063216
28tricarboxylic acid cycle (GO:0006099)5.51961285
29actin filament-based movement (GO:0030048)5.48632143
30cardiac muscle hypertrophy (GO:0003300)5.43630295
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.42435486
32ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.22660001
33striated muscle hypertrophy (GO:0014897)5.20971918
34skeletal muscle fiber development (GO:0048741)5.17259154
35bundle of His cell to Purkinje myocyte communication (GO:0086069)5.16245296
36muscle tissue morphogenesis (GO:0060415)5.16158585
37regulation of cell communication by electrical coupling (GO:0010649)5.14966540
38response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.05186242
39skeletal muscle contraction (GO:0003009)5.02917892
40regulation of striated muscle contraction (GO:0006942)5.02221543
41myotube cell development (GO:0014904)4.94710376
42regulation of sarcomere organization (GO:0060297)4.90874433
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.88830588
44fatty acid transmembrane transport (GO:1902001)4.70777537
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.67866086
46heart process (GO:0003015)4.63682417
47heart contraction (GO:0060047)4.63682417
48regulation of membrane repolarization (GO:0060306)4.60016755
49heart trabecula formation (GO:0060347)4.59849778
50muscle hypertrophy (GO:0014896)4.59610865
51regulation of the force of heart contraction (GO:0002026)4.45726637
52cell communication involved in cardiac conduction (GO:0086065)4.44200411
53regulation of acyl-CoA biosynthetic process (GO:0050812)4.42874450
54skeletal muscle tissue regeneration (GO:0043403)4.16544120
55skeletal muscle tissue development (GO:0007519)4.15225041
56carnitine transmembrane transport (GO:1902603)4.13107468
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.10725148
58muscle contraction (GO:0006936)4.10258008
59response to inactivity (GO:0014854)4.09975356
60muscle cell fate commitment (GO:0042693)4.03835429
61cardiac muscle cell action potential (GO:0086001)4.03385172
62striated muscle cell development (GO:0055002)4.03332191
63creatine metabolic process (GO:0006600)4.02267606
64regulation of coenzyme metabolic process (GO:0051196)4.01369805
65regulation of cofactor metabolic process (GO:0051193)4.01369805
66skeletal muscle adaptation (GO:0043501)4.01175176
67cell communication by electrical coupling (GO:0010644)3.99207446
68cardiac muscle cell action potential involved in contraction (GO:0086002)3.97477424
69muscle cell cellular homeostasis (GO:0046716)3.95722070
70regulation of cardiac muscle contraction (GO:0055117)3.95443476
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.89620274
72regulation of heart rate (GO:0002027)3.88911162
73muscle adaptation (GO:0043500)3.87148440
74negative regulation of protein localization to cell surface (GO:2000009)3.83658651
75negative regulation of potassium ion transport (GO:0043267)3.82753572
76muscle system process (GO:0003012)3.77996869
77muscle atrophy (GO:0014889)3.77134683
78amino-acid betaine transport (GO:0015838)3.76218280
79carnitine transport (GO:0015879)3.76218280
80regulation of ATPase activity (GO:0043462)3.74108666
81regulation of ATP catabolic process (GO:1903289)3.74108666
82regulation of cardiac muscle cell contraction (GO:0086004)3.69920478
83striated muscle adaptation (GO:0014888)3.68077736
84negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.66144341
85cardiac muscle hypertrophy in response to stress (GO:0014898)3.65295311
86muscle hypertrophy in response to stress (GO:0003299)3.65295311
87cardiac muscle adaptation (GO:0014887)3.65295311
88negative regulation of striated muscle cell apoptotic process (GO:0010664)3.63197534
89regulation of muscle system process (GO:0090257)3.60392742
90regulation of heart contraction (GO:0008016)3.58021095
91positive regulation of cation channel activity (GO:2001259)3.57934867
92muscle organ development (GO:0007517)3.54573474
93muscle structure development (GO:0061061)3.53264806
94regulation of calcium ion transmembrane transporter activity (GO:1901019)3.51409126
95regulation of calcium ion transmembrane transport (GO:1903169)3.51409126
96cardiac chamber formation (GO:0003207)3.48966326
97positive regulation of myotube differentiation (GO:0010831)3.48193487
98regulation of myoblast differentiation (GO:0045661)3.45740797
99muscle cell development (GO:0055001)3.45654441
100glycogen biosynthetic process (GO:0005978)3.43582146
101glucan biosynthetic process (GO:0009250)3.43582146
102muscle fiber development (GO:0048747)3.42499774
103regulation of muscle contraction (GO:0006937)3.41820463
104relaxation of cardiac muscle (GO:0055119)3.39738328
1052-oxoglutarate metabolic process (GO:0006103)3.39195210
106striated muscle atrophy (GO:0014891)3.37136602
107oxygen transport (GO:0015671)3.36804550
108response to caffeine (GO:0031000)3.35240345
109NADH metabolic process (GO:0006734)3.33793493
110glucan catabolic process (GO:0009251)3.32997840
111cardiac conduction (GO:0061337)3.32528442
112regulation of cardioblast differentiation (GO:0051890)3.31168226
113positive regulation of heart rate (GO:0010460)3.30385486
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29705270
115glycogen catabolic process (GO:0005980)3.29200449
116response to muscle activity (GO:0014850)3.26137351
117regulation of skeletal muscle cell differentiation (GO:2001014)3.25716464
118regulation of sulfur metabolic process (GO:0042762)3.24824554
119striated muscle tissue development (GO:0014706)3.24632381
120regulation of sequestering of triglyceride (GO:0010889)3.24365439
121regulation of heart rate by cardiac conduction (GO:0086091)3.24084256
122positive regulation of myoblast differentiation (GO:0045663)3.23997398
123positive regulation of heart contraction (GO:0045823)3.23478106
124cardiac ventricle formation (GO:0003211)3.15022576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.44766795
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.46633063
3* TBX20_22080862_ChIP-Seq_HEART_Mouse4.05128925
4* TBX20_22328084_ChIP-Seq_HEART_Mouse4.05128925
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.69260824
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61739495
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.37656084
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.36150474
9ZNF263_19887448_ChIP-Seq_K562_Human3.35442314
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.15410054
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.08559529
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.68767341
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47309527
14GATA4_21415370_ChIP-Seq_HL-1_Mouse2.26290960
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22022294
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21159078
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12846127
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07735630
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06693665
20EZH2_22144423_ChIP-Seq_EOC_Human1.95704217
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94087343
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.91769598
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82289490
24NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.75544797
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69912136
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65111460
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65079159
28CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63064737
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62919612
30CTCF_27219007_Chip-Seq_Bcells_Human1.50887137
31* KDM2B_26808549_Chip-Seq_DND41_Human1.46932678
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.46007424
33GATA1_22025678_ChIP-Seq_K562_Human1.42535580
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41214212
35LXR_22292898_ChIP-Seq_THP-1_Human1.41022555
36GBX2_23144817_ChIP-Seq_PC3_Human1.39308033
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38949895
38* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38869824
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34344622
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28864300
41* TP63_22573176_ChIP-Seq_HFKS_Human1.27778284
42IGF1R_20145208_ChIP-Seq_DFB_Human1.27618158
43CLOCK_20551151_ChIP-Seq_293T_Human1.27157996
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24334722
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24192534
46RACK7_27058665_Chip-Seq_MCF-7_Human1.23168647
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21485473
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21047605
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20630433
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.20205945
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19931545
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19656697
53* DROSHA_22980978_ChIP-Seq_HELA_Human1.19375607
54VDR_22108803_ChIP-Seq_LS180_Human1.17728924
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17548365
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15011873
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.12469619
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11510637
59GATA1_19941826_ChIP-Seq_K562_Human1.11368942
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.11166352
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10740896
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10373600
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09913802
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07443501
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06410102
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06314472
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05939294
68SPI1_20517297_ChIP-Seq_HL60_Human1.04830403
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.04761159
70* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03947921
71* LXR_22158963_ChIP-Seq_LIVER_Mouse1.03617938
72ATF3_27146783_Chip-Seq_COLON_Human1.03130223
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.03122593
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02562194
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02552823
76P68_20966046_ChIP-Seq_HELA_Human1.02415058
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02270223
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.00649500
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.00013718
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.99848515
81* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99472338
82* SMAD4_21799915_ChIP-Seq_A2780_Human0.99098179
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98576481
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98576481
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97863066
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97302763
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.96776010
88KDM2B_26808549_Chip-Seq_K562_Human0.96412735
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96324448
90CTCF_21964334_Chip-Seq_Bcells_Human0.95634783
91RARB_27405468_Chip-Seq_BRAIN_Mouse0.95516907
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95343130
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95156668
94TCF7_22412390_ChIP-Seq_EML_Mouse0.94895607
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94501337
96SPI1_23127762_ChIP-Seq_K562_Human0.94355999
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.93429742
98* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93211187
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93187757
100OCT4_20526341_ChIP-Seq_ESCs_Human0.92744955
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91319023
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91281085
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90823974
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90762610
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89447677
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88609999
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.88370565
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.88227182
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.88186046
110* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87863804
111* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87468679
112CREB1_26743006_Chip-Seq_LNCaP_Human0.86546375
113GATA2_19941826_ChIP-Seq_K562_Human0.86207916
114* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85850705
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.85318462
116KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84312567
117BCL6_27268052_Chip-Seq_Bcells_Human0.84193424
118AR_21572438_ChIP-Seq_LNCaP_Human0.84104054
119ZNF274_21170338_ChIP-Seq_K562_Hela0.83614200
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.83577558
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.82933641
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82858973
123SMC4_20622854_ChIP-Seq_HELA_Human0.81988381
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81923031
125E2F1_20622854_ChIP-Seq_HELA_Human0.81572230
126CJUN_26792858_Chip-Seq_BT549_Human0.81560384
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81446539
128BCOR_27268052_Chip-Seq_Bcells_Human0.81296228
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80599332
130* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80115602
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79710080
132TBL1_22424771_ChIP-Seq_293T_Human0.79683090
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79427502
134* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79186396
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79099257
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78904100
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.77791458
138AR_19668381_ChIP-Seq_PC3_Human0.77703550
139* GF1_26923725_Chip-Seq_HPCs_Mouse0.76278547
140* SMAD4_21741376_ChIP-Seq_HESCs_Human0.75848209
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75511072
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75464457
143GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75150044
144KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72483334
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.72249209
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71532491
147* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71238154
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.70945824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.72263677
2MP0003646_muscle_fatigue5.65874892
3MP0000751_myopathy5.58383085
4MP0004084_abnormal_cardiac_muscle5.32183273
5MP0000749_muscle_degeneration4.49614757
6MP0004215_abnormal_myocardial_fiber4.48010845
7MP0004036_abnormal_muscle_relaxation4.28433296
8MP0005330_cardiomyopathy3.79064642
9MP0004145_abnormal_muscle_electrophysio3.45329834
10* MP0004087_abnormal_muscle_fiber3.26091522
11MP0000750_abnormal_muscle_regeneration3.02977658
12MP0002106_abnormal_muscle_physiology2.95254535
13MP0002972_abnormal_cardiac_muscle2.93717821
14MP0005620_abnormal_muscle_contractility2.84446210
15MP0003137_abnormal_impulse_conducting2.78721381
16MP0002269_muscular_atrophy2.68819905
17MP0008775_abnormal_heart_ventricle2.63935373
18MP0004130_abnormal_muscle_cell2.51684703
19* MP0010630_abnormal_cardiac_muscle2.50158399
20MP0000747_muscle_weakness2.49974528
21MP0005385_cardiovascular_system_phenoty2.40601139
22MP0001544_abnormal_cardiovascular_syste2.40601139
23MP0005369_muscle_phenotype2.40533340
24MP0000759_abnormal_skeletal_muscle2.35994820
25MP0004484_altered_response_of2.27336195
26MP0006138_congestive_heart_failure2.11196443
27MP0004510_myositis2.08143164
28MP0003828_pulmonary_edema2.06161176
29MP0004233_abnormal_muscle_weight2.03514313
30MP0003221_abnormal_cardiomyocyte_apopto1.92149739
31MP0004085_abnormal_heartbeat1.86349182
32MP0003950_abnormal_plasma_membrane1.74020490
33MP0002127_abnormal_cardiovascular_syste1.62842922
34MP0006036_abnormal_mitochondrial_physio1.52591737
35MP0002332_abnormal_exercise_endurance1.49097840
36MP0005666_abnormal_adipose_tissue1.46076852
37MP0005670_abnormal_white_adipose1.37829217
38MP0004270_analgesia1.34428572
39MP0001661_extended_life_span1.34255413
40MP0003567_abnormal_fetal_cardiomyocyte1.26542251
41MP0002108_abnormal_muscle_morphology1.15543778
42* MP0000266_abnormal_heart_morphology1.09906834
43MP0004185_abnormal_adipocyte_glucose1.08585160
44MP0000733_abnormal_muscle_development1.08494412
45MP0000343_altered_response_to1.06296812
46MP0005375_adipose_tissue_phenotype1.02045659
47MP0002234_abnormal_pharynx_morphology1.00119564
48MP0003279_aneurysm0.95759232
49MP0010368_abnormal_lymphatic_system0.94081676
50MP0005165_increased_susceptibility_to0.88045139
51MP0006035_abnormal_mitochondrial_morpho0.84721007
52MP0003705_abnormal_hypodermis_morpholog0.83812836
53MP0005266_abnormal_metabolism0.81651375
54MP0003566_abnormal_cell_adhesion0.74588512
55MP0005623_abnormal_meninges_morphology0.73402961
56* MP0002128_abnormal_blood_circulation0.71998019
57MP0002971_abnormal_brown_adipose0.68257104
58MP0000013_abnormal_adipose_tissue0.68017864
59MP0000230_abnormal_systemic_arterial0.61349212
60MP0003045_fibrosis0.60592076
61MP0000003_abnormal_adipose_tissue0.59404840
62MP0000767_abnormal_smooth_muscle0.57589467
63MP0005451_abnormal_body_composition0.54253665
64MP0001879_abnormal_lymphatic_vessel0.49379955
65MP0003806_abnormal_nucleotide_metabolis0.48906433
66MP0002909_abnormal_adrenal_gland0.47078788
67MP0008438_abnormal_cutaneous_collagen0.46255716
68MP0005275_abnormal_skin_tensile0.45923643
69* MP0002925_abnormal_cardiovascular_devel0.44291775
70MP0004272_abnormal_basement_membrane0.43694210
71MP0000372_irregular_coat_pigmentation0.42220605
72MP0008961_abnormal_basal_metabolism0.41949161
73MP0002078_abnormal_glucose_homeostasis0.41546001
74MP0005319_abnormal_enzyme/_coenzyme0.41378302
75MP0005187_abnormal_penis_morphology0.39797746
76MP0002822_catalepsy0.38378731
77MP0003984_embryonic_growth_retardation0.37646122
78MP0004134_abnormal_chest_morphology0.37427800
79MP0004043_abnormal_pH_regulation0.36998804
80MP0003879_abnormal_hair_cell0.36631174
81MP0002088_abnormal_embryonic_growth/wei0.36468594
82MP0003948_abnormal_gas_homeostasis0.34552440
83* MP0001784_abnormal_fluid_regulation0.33814571
84MP0008569_lethality_at_weaning0.33439565
85MP0005334_abnormal_fat_pad0.31996883
86* MP0001614_abnormal_blood_vessel0.31426632
87MP0009115_abnormal_fat_cell0.30545404
88MP0003656_abnormal_erythrocyte_physiolo0.30038021
89MP0004147_increased_porphyrin_level0.29321201
90MP0006276_abnormal_autonomic_nervous0.25793264
91MP0002114_abnormal_axial_skeleton0.25602232
92MP0000579_abnormal_nail_morphology0.25504612
93MP0009384_cardiac_valve_regurgitation0.25232592
94MP0001849_ear_inflammation0.24248847
95MP0005584_abnormal_enzyme/coenzyme_acti0.22783582
96MP0004142_abnormal_muscle_tone0.21708343
97MP0005535_abnormal_body_temperature0.21665775
98MP0009780_abnormal_chondrocyte_physiolo0.21032254
99MP0001529_abnormal_vocalization0.20521465
100MP0003385_abnormal_body_wall0.19812639
101MP0005452_abnormal_adipose_tissue0.19573910
102MP0005595_abnormal_vascular_smooth0.19496277
103MP0009250_abnormal_appendicular_skeleto0.19390622
104MP0010030_abnormal_orbit_morphology0.19221580
105MP0002970_abnormal_white_adipose0.19122349
106MP0005380_embryogenesis_phenotype0.18934675
107MP0001672_abnormal_embryogenesis/_devel0.18934675
108MP0009672_abnormal_birth_weight0.18399356
109MP0001943_abnormal_respiration0.17735129
110MP0002638_abnormal_pupillary_reflex0.17607348
111MP0001727_abnormal_embryo_implantation0.16518112
112MP0002896_abnormal_bone_mineralization0.16057624
113MP0001299_abnormal_eye_distance/0.15871831
114MP0002118_abnormal_lipid_homeostasis0.15714973
115MP0000249_abnormal_blood_vessel0.15475530
116MP0005376_homeostasis/metabolism_phenot0.14030762
117MP0003941_abnormal_skin_development0.13865131
118MP0000762_abnormal_tongue_morphology0.13553879
119MP0001958_emphysema0.12992236
120MP0008874_decreased_physiological_sensi0.12852918

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.13224883
2Calf muscle hypertrophy (HP:0008981)6.79713324
3Exercise-induced myalgia (HP:0003738)6.77703087
4Muscle fiber splitting (HP:0003555)6.51335298
5Muscle hypertrophy of the lower extremities (HP:0008968)6.47845774
6Exercise-induced muscle cramps (HP:0003710)6.43419588
7Ventricular tachycardia (HP:0004756)6.34041580
8Abnormality of the calf musculature (HP:0001430)5.67191116
9Hyporeflexia of lower limbs (HP:0002600)5.59475834
10Abnormality of the left ventricular outflow tract (HP:0011103)5.39962016
11Subaortic stenosis (HP:0001682)5.39962016
12Atrial fibrillation (HP:0005110)5.39240051
13Primary atrial arrhythmia (HP:0001692)5.03892463
14Lipoatrophy (HP:0100578)5.00805626
15EMG: myopathic abnormalities (HP:0003458)4.86819915
16Supraventricular tachycardia (HP:0004755)4.86574499
17Muscle fiber inclusion bodies (HP:0100299)4.85886082
18Myoglobinuria (HP:0002913)4.85345059
19Supraventricular arrhythmia (HP:0005115)4.77341802
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.76510187
21Right ventricular cardiomyopathy (HP:0011663)4.69136631
22Type 1 muscle fiber predominance (HP:0003803)4.64536888
23Increased connective tissue (HP:0009025)4.52398550
24Syncope (HP:0001279)4.40994534
25Asymmetric septal hypertrophy (HP:0001670)4.31679412
26Difficulty running (HP:0009046)4.27653973
27Dilated cardiomyopathy (HP:0001644)4.18539033
28Bundle branch block (HP:0011710)4.18236586
29Prolonged QT interval (HP:0001657)4.06221949
30Nemaline bodies (HP:0003798)3.99711938
31Myotonia (HP:0002486)3.83905239
32Palpitations (HP:0001962)3.83259441
33Ventricular arrhythmia (HP:0004308)3.82551318
34Rhabdomyolysis (HP:0003201)3.76760378
35Heart block (HP:0012722)3.49474739
36Difficulty climbing stairs (HP:0003551)3.47088464
37Atrioventricular block (HP:0001678)3.35878832
38Ventricular fibrillation (HP:0001663)3.32624907
39Abnormal atrioventricular conduction (HP:0005150)3.30349194
40Malignant hyperthermia (HP:0002047)3.24211926
41Neck muscle weakness (HP:0000467)3.16868221
42Absent phalangeal crease (HP:0006109)3.08703114
43Distal arthrogryposis (HP:0005684)3.06902857
44Fetal akinesia sequence (HP:0001989)3.03466618
45Deformed tarsal bones (HP:0008119)3.00671334
46Muscle stiffness (HP:0003552)2.98726878
47Abnormal EKG (HP:0003115)2.94520322
48Increased variability in muscle fiber diameter (HP:0003557)2.92765844
49Abnormality of skeletal muscle fiber size (HP:0012084)2.89591887
50Areflexia of lower limbs (HP:0002522)2.83596559
51Round ear (HP:0100830)2.81189018
52Mildly elevated creatine phosphokinase (HP:0008180)2.68944773
53Distal lower limb muscle weakness (HP:0009053)2.67002312
54Left ventricular hypertrophy (HP:0001712)2.65708972
55Myopathic facies (HP:0002058)2.63261869
56Weak cry (HP:0001612)2.63171362
57Abnormal finger flexion creases (HP:0006143)2.60040004
58Rimmed vacuoles (HP:0003805)2.59232545
59Popliteal pterygium (HP:0009756)2.57513530
60EMG: neuropathic changes (HP:0003445)2.54050052
61Palmoplantar keratoderma (HP:0000982)2.47017893
62Hypoplastic ischia (HP:0003175)2.43592522
63Testicular atrophy (HP:0000029)2.39797287
64Limb-girdle muscle atrophy (HP:0003797)2.38091769
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.37747309
66Type 2 muscle fiber atrophy (HP:0003554)2.35502647
67Generalized muscle weakness (HP:0003324)2.31622867
68Distal lower limb amyotrophy (HP:0008944)2.30994603
69Gowers sign (HP:0003391)2.30202867
70Muscular dystrophy (HP:0003560)2.30119595
71Scapular winging (HP:0003691)2.24243398
72Ketoacidosis (HP:0001993)2.22475108
73Facial diplegia (HP:0001349)2.21092536
74Ulnar deviation of the wrist (HP:0003049)2.19619206
75Abnormality of the foot musculature (HP:0001436)2.16102500
76Muscle fiber atrophy (HP:0100295)2.13067021
77Abnormality of the ischium (HP:0003174)2.11476512
78Slender build (HP:0001533)2.09570761
79Waddling gait (HP:0002515)2.07886278
80Frequent falls (HP:0002359)2.06574398
81Abnormality of the shoulder girdle musculature (HP:0001435)2.04658817
82Hyperkalemia (HP:0002153)2.01957122
83Hepatic necrosis (HP:0002605)2.00753691
84Hip contracture (HP:0003273)1.99836466
85Foot dorsiflexor weakness (HP:0009027)1.99691392
86Proximal amyotrophy (HP:0007126)1.98305222
87Respiratory insufficiency due to muscle weakness (HP:0002747)1.97760936
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97381415
89Ragged-red muscle fibers (HP:0003200)1.97272373
90Abnormal mitochondria in muscle tissue (HP:0008316)1.97269854
91Abnormality of the calcaneus (HP:0008364)1.96442586
92Sudden cardiac death (HP:0001645)1.96426008
93Progressive muscle weakness (HP:0003323)1.93834175
94Large for gestational age (HP:0001520)1.93509332
95Acute necrotizing encephalopathy (HP:0006965)1.90497838
96Hypoglycemic coma (HP:0001325)1.89082601
97Nonprogressive disorder (HP:0003680)1.84048570
98Dysmetric saccades (HP:0000641)1.83659524
99Congestive heart failure (HP:0001635)1.82640245
100Fatigable weakness (HP:0003473)1.80882812
101Abnormality of the neuromuscular junction (HP:0003398)1.80882812
102Bulbar palsy (HP:0001283)1.80425483
103Increased muscle lipid content (HP:0009058)1.80368110
104Abnormality of placental membranes (HP:0011409)1.78263168
105Amniotic constriction ring (HP:0009775)1.78263168
106Spinal rigidity (HP:0003306)1.78112639
107Lower limb amyotrophy (HP:0007210)1.77627707
108Aplasia of the musculature (HP:0100854)1.76384798
109Conjunctival hamartoma (HP:0100780)1.73832931
110Long clavicles (HP:0000890)1.71454819
111Hepatocellular necrosis (HP:0001404)1.71146403
112Steppage gait (HP:0003376)1.70916236
113Diaphragmatic weakness (HP:0009113)1.70613145
114Exercise intolerance (HP:0003546)1.68642756
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68031774
116Dicarboxylic aciduria (HP:0003215)1.68031774
117Abnormality of fatty-acid metabolism (HP:0004359)1.66214001
118Limb-girdle muscle weakness (HP:0003325)1.66195640
119Calcaneovalgus deformity (HP:0001848)1.65573251
120Easy fatigability (HP:0003388)1.65547001
121Limited hip movement (HP:0008800)1.63350438
122Hyperinsulinemic hypoglycemia (HP:0000825)1.62423591
123Acute encephalopathy (HP:0006846)1.61835814
124Abnormality of the musculature of the pelvis (HP:0001469)1.61141688
125Abnormality of the hip-girdle musculature (HP:0001445)1.61141688
126Shoulder girdle muscle weakness (HP:0003547)1.58930228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.67074519
2TTN5.69211536
3PHKG24.34033296
4PHKG14.34033296
5DMPK3.29942152
6PDK33.02783650
7PDK43.02783650
8LMTK22.93717685
9MYLK2.85268004
10MUSK2.70791787
11TRIB32.68679187
12PKN22.53898988
13PIK3CA2.16183334
14PINK12.09174012
15NEK12.03449744
16BCKDK1.90964769
17PDK21.82094801
18TIE11.66639053
19STK241.55947050
20CCNB11.44931629
21ZAK1.32881505
22MAP3K71.29430384
23PIK3CG1.26455925
24MAP2K31.21717914
25PRKD11.18190832
26NME11.17660954
27MAPK121.17401832
28ILK1.16260167
29CAMK2D1.16183279
30ICK1.15950491
31MARK11.15577710
32EEF2K1.12867003
33GRK71.03912359
34INSRR1.03654889
35PAK30.98591273
36LIMK10.97534088
37TRPM70.96506222
38CDC42BPA0.95679793
39PRKAA10.95630392
40MAPKAPK30.94237966
41PRKAA20.91491395
42RIPK10.89685683
43ROCK10.89044873
44MOS0.88098857
45MAP3K50.84138643
46PDGFRA0.78366940
47EPHB10.76499317
48MAP3K30.74516879
49PKN10.74138779
50STK40.73453981
51TGFBR20.70010388
52KSR20.66417072
53WNK40.66097087
54MAP2K10.63005725
55SIK10.62399246
56FLT30.61639577
57STK38L0.60919062
58STK380.60198701
59MAPK40.57881673
60CAMK40.57469437
61RPS6KC10.55384602
62RPS6KL10.55384602
63PTK2B0.51420384
64AKT20.51013592
65DAPK30.49890279
66WNK10.48420227
67ROCK20.47287647
68CAMK2A0.46593503
69PRKACB0.46404510
70RPS6KA60.45862533
71EPHA30.44925737
72MAP3K130.44556894
73CAMK2B0.43760206
74MAP3K100.40914324
75ERBB30.39886255
76PTK60.38769970
77MTOR0.37226670
78CAMK10.35663272
79PRKACA0.35038264
80MARK20.34939902
81MAP3K110.34509200
82CAMK2G0.34474192
83KDR0.34104786
84PRKACG0.33044460
85PRKD30.32998736
86DYRK1B0.32122573
87PDPK10.31046143
88MAP3K60.30095746
89SGK20.29887646
90MAPK110.29762751
91LATS10.28754295
92MAP2K60.28590353
93NLK0.27898340
94RPS6KA10.27781255
95RPS6KB20.27280648
96NEK90.26828172
97RPS6KB10.26335295
98CAMK1G0.25603335
99PDK10.25167356
100LATS20.24634742
101MAPK100.24620543
102PRKG10.24204021
103PRKCE0.24099258
104TAOK10.23328647
105RAF10.22577727
106MAP2K40.22281126
107SGK10.21354489
108PRKD20.20268390
109ZAP700.20097092
110RPS6KA30.19876277
111STK110.19247542
112PRKCH0.18496527
113FGFR30.18472545
114MAPK70.17611059
115CAMK1D0.16787857
116JAK10.14286184
117SGK30.14019687
118PDGFRB0.13918371
119EPHB20.13040000
120FER0.11192439
121RPS6KA20.11100441
122IRAK30.09870101
123RET0.09702845
124MAP3K10.09188823
125STK390.08118787

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.42083898
2Cardiac muscle contraction_Homo sapiens_hsa042604.53887138
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.36066405
4Dilated cardiomyopathy_Homo sapiens_hsa054144.31651931
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.10444667
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09594544
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.03765391
8Propanoate metabolism_Homo sapiens_hsa006402.88271067
9Parkinsons disease_Homo sapiens_hsa050122.55812663
10Fatty acid degradation_Homo sapiens_hsa000712.51045897
11Oxidative phosphorylation_Homo sapiens_hsa001902.38066518
12Carbon metabolism_Homo sapiens_hsa012002.27447287
13Viral myocarditis_Homo sapiens_hsa054162.12219181
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.03882308
15Fatty acid metabolism_Homo sapiens_hsa012122.00195502
16Alzheimers disease_Homo sapiens_hsa050101.94052698
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82828498
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81713782
19Pyruvate metabolism_Homo sapiens_hsa006201.58059239
20Huntingtons disease_Homo sapiens_hsa050161.52601260
21Insulin resistance_Homo sapiens_hsa049311.33342368
22Glucagon signaling pathway_Homo sapiens_hsa049221.31975029
23Starch and sucrose metabolism_Homo sapiens_hsa005001.29370164
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27062340
25Insulin signaling pathway_Homo sapiens_hsa049101.20876121
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18061504
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.15469456
28Biosynthesis of amino acids_Homo sapiens_hsa012301.15278308
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14312370
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00743315
31Butanoate metabolism_Homo sapiens_hsa006500.99996646
32Fatty acid biosynthesis_Homo sapiens_hsa000610.98034150
33Lysine degradation_Homo sapiens_hsa003100.97756198
34Fatty acid elongation_Homo sapiens_hsa000620.97581455
35PPAR signaling pathway_Homo sapiens_hsa033200.97572251
36Oxytocin signaling pathway_Homo sapiens_hsa049210.94522914
37Calcium signaling pathway_Homo sapiens_hsa040200.94107251
38AMPK signaling pathway_Homo sapiens_hsa041520.94096487
39Focal adhesion_Homo sapiens_hsa045100.92507709
40Tight junction_Homo sapiens_hsa045300.86053959
41Type II diabetes mellitus_Homo sapiens_hsa049300.81470732
42HIF-1 signaling pathway_Homo sapiens_hsa040660.77916400
43Long-term potentiation_Homo sapiens_hsa047200.77658065
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.73605152
45Arginine and proline metabolism_Homo sapiens_hsa003300.73498493
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73324633
47Circadian rhythm_Homo sapiens_hsa047100.72196240
48Galactose metabolism_Homo sapiens_hsa000520.71518215
49Arginine biosynthesis_Homo sapiens_hsa002200.68759939
50Fructose and mannose metabolism_Homo sapiens_hsa000510.65565986
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65349040
52Adherens junction_Homo sapiens_hsa045200.64782072
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63895638
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61854125
55Tryptophan metabolism_Homo sapiens_hsa003800.60335529
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.58296649
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57839756
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57717315
59Renin secretion_Homo sapiens_hsa049240.57668500
60beta-Alanine metabolism_Homo sapiens_hsa004100.54565290
61Insulin secretion_Homo sapiens_hsa049110.53367363
62ECM-receptor interaction_Homo sapiens_hsa045120.53161845
63Nitrogen metabolism_Homo sapiens_hsa009100.51021277
64Salivary secretion_Homo sapiens_hsa049700.50909518
65Gastric acid secretion_Homo sapiens_hsa049710.49028861
66cAMP signaling pathway_Homo sapiens_hsa040240.46264934
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44606046
68mTOR signaling pathway_Homo sapiens_hsa041500.42609976
69Amoebiasis_Homo sapiens_hsa051460.41777716
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39506978
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39003035
72Amphetamine addiction_Homo sapiens_hsa050310.36364556
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36158992
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35220886
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34436289
76VEGF signaling pathway_Homo sapiens_hsa043700.34309669
77GnRH signaling pathway_Homo sapiens_hsa049120.33437762
78Phenylalanine metabolism_Homo sapiens_hsa003600.32294313
79Proteoglycans in cancer_Homo sapiens_hsa052050.30380556
80Dorso-ventral axis formation_Homo sapiens_hsa043200.30036602
81Circadian entrainment_Homo sapiens_hsa047130.28407754
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.26655277
83Sulfur metabolism_Homo sapiens_hsa009200.26396247
84Platelet activation_Homo sapiens_hsa046110.25958438
85Olfactory transduction_Homo sapiens_hsa047400.25420400
86Notch signaling pathway_Homo sapiens_hsa043300.25158143
87Melanogenesis_Homo sapiens_hsa049160.24642007
88Glioma_Homo sapiens_hsa052140.24036101
89Endometrial cancer_Homo sapiens_hsa052130.23886193
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23553684
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.23364456
92Renal cell carcinoma_Homo sapiens_hsa052110.22977283
93Peroxisome_Homo sapiens_hsa041460.20235739
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18854199
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18853208
96FoxO signaling pathway_Homo sapiens_hsa040680.18460468
97MAPK signaling pathway_Homo sapiens_hsa040100.18336551
98GABAergic synapse_Homo sapiens_hsa047270.17549142
99Oocyte meiosis_Homo sapiens_hsa041140.17356708
100Long-term depression_Homo sapiens_hsa047300.16864040
101ABC transporters_Homo sapiens_hsa020100.16569480
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16171650
103Gap junction_Homo sapiens_hsa045400.15111564
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14055594
105Pancreatic secretion_Homo sapiens_hsa049720.13945054
106Ovarian steroidogenesis_Homo sapiens_hsa049130.12447291
107Metabolic pathways_Homo sapiens_hsa011000.10320762
108Fat digestion and absorption_Homo sapiens_hsa049750.09206938
109Cholinergic synapse_Homo sapiens_hsa047250.09123477
110Small cell lung cancer_Homo sapiens_hsa052220.07605561
111Toxoplasmosis_Homo sapiens_hsa051450.06936903
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06399376
113Bile secretion_Homo sapiens_hsa049760.06329846
114Acute myeloid leukemia_Homo sapiens_hsa052210.05066553
115Estrogen signaling pathway_Homo sapiens_hsa049150.04058391
116Pentose phosphate pathway_Homo sapiens_hsa000300.03536938
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.02814483
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02715569
119Glycerolipid metabolism_Homo sapiens_hsa005610.01931953

Most similar genes based on co-expression Upload to Enrichr

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