MYO1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.03698222
2cell adhesion mediated by integrin (GO:0033627)4.11569851
3modulation by symbiont of host immune response (GO:0052553)4.09388733
4positive regulation by symbiont of host defense response (GO:0052509)4.09388733
5modulation by symbiont of host defense response (GO:0052031)4.09388733
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09388733
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09388733
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.09388733
9desmosome organization (GO:0002934)3.87366113
10* glomerular visceral epithelial cell development (GO:0072015)3.79854121
11positive regulation of interferon-alpha production (GO:0032727)3.69840363
12cell-substrate junction assembly (GO:0007044)3.67520281
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65736838
14COPI coating of Golgi vesicle (GO:0048205)3.57795538
15Golgi transport vesicle coating (GO:0048200)3.57795538
16barbed-end actin filament capping (GO:0051016)3.56605609
17epithelial cell-cell adhesion (GO:0090136)3.56394228
18regulation of interferon-alpha production (GO:0032647)3.55476480
19* glomerular epithelial cell development (GO:0072310)3.52360215
20apoptotic cell clearance (GO:0043277)3.45604875
21wound healing, spreading of epidermal cells (GO:0035313)3.45263029
22regulation of vitamin metabolic process (GO:0030656)3.37686701
23glycosphingolipid catabolic process (GO:0046479)3.24702794
24regulation of cholesterol storage (GO:0010885)3.22184459
25macrophage activation involved in immune response (GO:0002281)3.20930257
26regulation of early endosome to late endosome transport (GO:2000641)3.18924976
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17143047
28retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16086610
29regulation of vitamin D biosynthetic process (GO:0060556)3.13672963
30response to laminar fluid shear stress (GO:0034616)3.11142839
31positive regulation of p38MAPK cascade (GO:1900745)3.08821617
32stress fiber assembly (GO:0043149)3.08225621
33low-density lipoprotein particle clearance (GO:0034383)3.05747177
34adhesion of symbiont to host (GO:0044406)2.98567665
35protein localization to endosome (GO:0036010)2.98234206
36positive regulation of extracellular matrix organization (GO:1903055)2.95390528
37regulation of membrane protein ectodomain proteolysis (GO:0051043)2.93310366
38glycolipid catabolic process (GO:0019377)2.91637722
39skin morphogenesis (GO:0043589)2.91612338
40peptidyl-glutamic acid carboxylation (GO:0017187)2.89570859
41protein carboxylation (GO:0018214)2.89570859
42adhesion of symbiont to host cell (GO:0044650)2.85922166
43virion attachment to host cell (GO:0019062)2.85922166
44activation of Rac GTPase activity (GO:0032863)2.85037168
45regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82310410
46antigen processing and presentation of endogenous antigen (GO:0019883)2.80980907
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.79739350
48focal adhesion assembly (GO:0048041)2.79060292
49cell-substrate adherens junction assembly (GO:0007045)2.79060292
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78404412
51adherens junction assembly (GO:0034333)2.77605366
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.76896279
53urea cycle (GO:0000050)2.75950720
54negative regulation of anoikis (GO:2000811)2.75664687
55hypotonic response (GO:0006971)2.74314204
56wound healing, spreading of cells (GO:0044319)2.72868241
57oligosaccharide catabolic process (GO:0009313)2.72154418
58membrane protein ectodomain proteolysis (GO:0006509)2.71883209
59regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71730204
60neutrophil activation involved in immune response (GO:0002283)2.71455152
61fibrinolysis (GO:0042730)2.68089678
62I-kappaB phosphorylation (GO:0007252)2.66578174
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63456633
64plasma lipoprotein particle clearance (GO:0034381)2.63014889
65regulation of interleukin-12 biosynthetic process (GO:0045075)2.62673573
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62520034
67protein hydroxylation (GO:0018126)2.61893606
68positive regulation of interferon-beta production (GO:0032728)2.60784732
69hemidesmosome assembly (GO:0031581)2.59107248
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58948381
71regulation of anoikis (GO:2000209)2.56204121
72regulation of mononuclear cell migration (GO:0071675)2.55534103
73hyaluronan catabolic process (GO:0030214)2.55117232
74regulation of integrin activation (GO:0033623)2.54379139
75sphingosine metabolic process (GO:0006670)2.52984039
76nuclear pore complex assembly (GO:0051292)2.52510011
77branching involved in mammary gland duct morphogenesis (GO:0060444)2.52138406
78vascular endothelial growth factor signaling pathway (GO:0038084)2.51739363
79bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51699160
80urea metabolic process (GO:0019627)2.51421215
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.50288200
82positive regulation of hemostasis (GO:1900048)2.50239236
83positive regulation of blood coagulation (GO:0030194)2.50239236
84positive regulation of keratinocyte differentiation (GO:0045618)2.49519934
85regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49144737
86cellular response to vitamin D (GO:0071305)2.48981584
87positive regulation of cell adhesion mediated by integrin (GO:0033630)2.47648797
88regulation of transforming growth factor beta1 production (GO:0032908)2.47288373
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47216657
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47216657
91endodermal cell differentiation (GO:0035987)2.46590325
92actin filament bundle assembly (GO:0051017)2.45757718
93actin filament bundle organization (GO:0061572)2.45757718
94T-helper 1 type immune response (GO:0042088)2.45047339
95peptidyl-proline hydroxylation (GO:0019511)2.44932764
96regulation of podosome assembly (GO:0071801)2.44844309
97regulation of B cell receptor signaling pathway (GO:0050855)2.44213067
98regulation of cholesterol homeostasis (GO:2000188)2.43110862
99negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.42565622
100positive regulation of coagulation (GO:0050820)2.42241158
101response to fluid shear stress (GO:0034405)2.41743939
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41011623
103immunoglobulin mediated immune response (GO:0016064)2.40812759
104gap junction assembly (GO:0016264)2.39515528
105* glomerular basement membrane development (GO:0032836)2.39157134
106iron ion import (GO:0097286)2.38462980
107regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.38284828
108ceramide catabolic process (GO:0046514)2.38185717
109basement membrane organization (GO:0071711)2.37764315
110response to host immune response (GO:0052572)2.37462528
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.37462528
112decidualization (GO:0046697)2.37448528
113activation of MAPKKK activity (GO:0000185)2.36431294
114collagen metabolic process (GO:0032963)2.36225841
115NIK/NF-kappaB signaling (GO:0038061)2.35942554
116COPII vesicle coating (GO:0048208)2.35867989
117multicellular organismal macromolecule metabolic process (GO:0044259)2.35826621
118embryonic process involved in female pregnancy (GO:0060136)2.35774059
119semaphorin-plexin signaling pathway (GO:0071526)2.35306024
120negative regulation of fibrinolysis (GO:0051918)2.34817902
121negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.34682926
122extracellular matrix disassembly (GO:0022617)2.31863994
123phospholipid efflux (GO:0033700)2.30240125
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.29855085
125regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.28907734
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28536069
127regulation of macrophage chemotaxis (GO:0010758)2.28326110
128mannose metabolic process (GO:0006013)2.27587393
129response to vitamin D (GO:0033280)2.27570497
130macrophage activation (GO:0042116)2.27245082
131response to host (GO:0075136)2.27006137
132response to host defenses (GO:0052200)2.27006137
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27006137
134collagen catabolic process (GO:0030574)2.26998832
135endocytic recycling (GO:0032456)2.25834028
136pinocytosis (GO:0006907)2.25400137
137multicellular organismal metabolic process (GO:0044236)2.25279025
138lipoprotein metabolic process (GO:0042157)2.24498107
139osteoclast differentiation (GO:0030316)2.24235868
140negative regulation of lipid storage (GO:0010888)2.24151008
141regulation of water loss via skin (GO:0033561)2.23373310
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.22486185
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21651249
144positive regulation of lipid storage (GO:0010884)2.21205250
145substrate-dependent cell migration (GO:0006929)2.21075913
146endothelial cell morphogenesis (GO:0001886)2.18321279
147regulation of protein activation cascade (GO:2000257)2.18141248
148regulation of heterotypic cell-cell adhesion (GO:0034114)2.18002653
149lipoprotein transport (GO:0042953)2.17594122
150complement activation, alternative pathway (GO:0006957)2.16374881
151cellular response to interferon-alpha (GO:0035457)2.16373334
152positive regulation of antigen processing and presentation (GO:0002579)2.16265736
153negative regulation of fatty acid transport (GO:2000192)2.16001592
154negative regulation of interleukin-8 production (GO:0032717)2.15709845
155regulation of complement activation (GO:0030449)2.15057822
156membrane raft organization (GO:0031579)2.14720009
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.14618929
158positive regulation of macrophage cytokine production (GO:0060907)2.14408176
159surfactant homeostasis (GO:0043129)2.12755555
160JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.12418407
161microglial cell activation (GO:0001774)2.12297716
162phospholipid homeostasis (GO:0055091)2.12118330
163positive regulation of endothelial cell apoptotic process (GO:2000353)2.11511869
164positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.09803878
165granulocyte activation (GO:0036230)2.09558250
166positive regulation of cellular amide metabolic process (GO:0034250)2.09431638
167regulation of macrophage cytokine production (GO:0010935)2.08750909
168positive regulation vascular endothelial growth factor production (GO:0010575)2.07136519
169neutrophil activation (GO:0042119)2.06817526
170integrin-mediated signaling pathway (GO:0007229)2.05643922
171regulation of macrophage derived foam cell differentiation (GO:0010743)2.05300715
172respiratory burst (GO:0045730)2.05150069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.40290869
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.81343171
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46638786
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21389688
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13479349
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.03197680
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98553296
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.91090864
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.72482082
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.68305523
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64890220
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.61666202
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59468518
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55869236
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.43290425
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41770482
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40888386
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30783039
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25637343
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.25208453
21ZNF263_19887448_ChIP-Seq_K562_Human2.20093609
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.10418174
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06085296
24CLOCK_20551151_ChIP-Seq_293T_Human2.00141420
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94265567
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.86593412
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.85323938
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79000912
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77477965
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.74902320
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70717011
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69302581
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67322984
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66158253
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66158253
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64113293
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64077851
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.61272328
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60709714
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59794951
41CJUN_26792858_Chip-Seq_BT549_Human1.59077586
42AR_21909140_ChIP-Seq_LNCAP_Human1.58586815
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56799217
44* GATA2_21666600_ChIP-Seq_HMVEC_Human1.54201065
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50531468
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50506791
47SOX2_20726797_ChIP-Seq_SW620_Human1.48751526
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46365899
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.45103016
50MYC_22102868_ChIP-Seq_BL_Human1.43525124
51* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41190577
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40597765
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36526688
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36354942
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35979282
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.35017587
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34208275
58* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32640676
59VDR_24787735_ChIP-Seq_THP-1_Human1.32353684
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32044749
61LXR_22292898_ChIP-Seq_THP-1_Human1.31784131
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29369073
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27802227
64* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25589298
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24973001
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24442117
67* TP53_22127205_ChIP-Seq_IMR90_Human1.24354545
68RUNX_20019798_ChIP-Seq_JUKART_Human1.24125074
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23952140
70GATA4_25053715_ChIP-Seq_YYC3_Human1.22860689
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18778676
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17420041
73* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16590749
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16302705
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16302705
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16159742
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16028313
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15149940
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14830473
80GATA6_25053715_ChIP-Seq_YYC3_Human1.14566845
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13857623
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12920408
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12052256
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11707189
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.11341965
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.11341965
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10595868
88SPI1_23127762_ChIP-Seq_K562_Human1.10230407
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09517077
90* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08764068
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08597239
92RACK7_27058665_Chip-Seq_MCF-7_Human1.08102566
93BRD4_25478319_ChIP-Seq_HGPS_Human1.07559299
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07299579
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.06901761
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06437785
97PU_27001747_Chip-Seq_BMDM_Mouse1.06262478
98ATF3_27146783_Chip-Seq_COLON_Human1.04554477
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03796282
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03416160
101VDR_21846776_ChIP-Seq_THP-1_Human1.01493389
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01262690
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.00908285
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99288801
105AHR_22903824_ChIP-Seq_MCF-7_Human0.98779375
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98344116
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98027616
108* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97986601
109MAF_26560356_Chip-Seq_TH1_Human0.97903652
110VDR_24763502_ChIP-Seq_THP-1_Human0.97154893
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96082686
112TP53_16413492_ChIP-PET_HCT116_Human0.95520108
113KDM2B_26808549_Chip-Seq_K562_Human0.95488024
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95176321
115* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94824084
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94772858
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.94580123
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94139698
119TCF7_22412390_ChIP-Seq_EML_Mouse0.93665879
120* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91936621
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91763049
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91734750
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.91016149
124TFEB_21752829_ChIP-Seq_HELA_Human0.90635150
125KLF5_25053715_ChIP-Seq_YYC3_Human0.90047413
126TP53_18474530_ChIP-ChIP_U2OS_Human0.89824655
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89277182
128* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88860417
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88466033
130FOXM1_23109430_ChIP-Seq_U2OS_Human0.87975323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.09410725
2MP0003303_peritoneal_inflammation2.90970451
3MP0002877_abnormal_melanocyte_morpholog2.85971675
4MP0003566_abnormal_cell_adhesion2.50757973
5MP0008438_abnormal_cutaneous_collagen2.49697531
6MP0003300_gastrointestinal_ulcer2.45003912
7MP0010352_gastrointestinal_tract_polyps2.23289223
8MP0005360_urolithiasis2.19768622
9MP0005058_abnormal_lysosome_morphology2.17034821
10MP0003436_decreased_susceptibility_to2.14316508
11MP0010234_abnormal_vibrissa_follicle2.10966590
12MP0001835_abnormal_antigen_presentation2.10007944
13MP0009840_abnormal_foam_cell2.04195791
14MP0002139_abnormal_hepatobiliary_system1.98139399
15MP0005275_abnormal_skin_tensile1.97495035
16MP0003191_abnormal_cellular_cholesterol1.96512180
17MP0005451_abnormal_body_composition1.83836662
18MP0004947_skin_inflammation1.81635117
19MP0005257_abnormal_intraocular_pressure1.80456581
20MP0005023_abnormal_wound_healing1.79665444
21MP0005387_immune_system_phenotype1.78046066
22MP0001790_abnormal_immune_system1.78046066
23MP0002254_reproductive_system_inflammat1.71049891
24MP0001849_ear_inflammation1.70738150
25MP0003091_abnormal_cell_migration1.65470690
26MP0002419_abnormal_innate_immunity1.63442817
27MP0006082_CNS_inflammation1.61500080
28MP0003453_abnormal_keratinocyte_physiol1.57837774
29MP0001958_emphysema1.53602951
30MP0005000_abnormal_immune_tolerance1.50845700
31MP0001800_abnormal_humoral_immune1.48519574
32MP0002452_abnormal_antigen_presenting1.48299181
33MP0001533_abnormal_skeleton_physiology1.47636792
34MP0003252_abnormal_bile_duct1.46052051
35MP0004272_abnormal_basement_membrane1.43896865
36MP0005076_abnormal_cell_differentiation1.43721409
37MP0000685_abnormal_immune_system1.42391888
38MP0003279_aneurysm1.41653392
39MP0005085_abnormal_gallbladder_physiolo1.41286809
40MP0000579_abnormal_nail_morphology1.41016323
41MP0005501_abnormal_skin_physiology1.35416965
42MP0002138_abnormal_hepatobiliary_system1.35246518
43MP0005409_darkened_coat_color1.30891957
44MP0002060_abnormal_skin_morphology1.30314837
45MP0002796_impaired_skin_barrier1.30206246
46MP0003448_altered_tumor_morphology1.26057474
47MP0002896_abnormal_bone_mineralization1.25772769
48MP0005083_abnormal_biliary_tract1.24974107
49MP0004233_abnormal_muscle_weight1.23377306
50MP0005365_abnormal_bile_salt1.22407461
51MP0002148_abnormal_hypersensitivity_rea1.21948088
52MP0002933_joint_inflammation1.21568515
53MP0005025_abnormal_response_to1.21312105
54MP0002998_abnormal_bone_remodeling1.20578697
55MP0000003_abnormal_adipose_tissue1.17046271
56MP0006054_spinal_hemorrhage1.16744212
57MP0002723_abnormal_immune_serum1.16417505
58MP0003724_increased_susceptibility_to1.15322723
59MP0005623_abnormal_meninges_morphology1.14330087
60MP0010329_abnormal_lipoprotein_level1.11986023
61MP0005464_abnormal_platelet_physiology1.11857500
62MP0000013_abnormal_adipose_tissue1.11822538
63* MP0000767_abnormal_smooth_muscle1.10872832
64MP0010368_abnormal_lymphatic_system1.10840365
65MP0001845_abnormal_inflammatory_respons1.10257572
66MP0003172_abnormal_lysosome_physiology1.10237526
67MP0009785_altered_susceptibility_to1.08635121
68MP0001879_abnormal_lymphatic_vessel1.08314132
69MP0008875_abnormal_xenobiotic_pharmacok1.07156325
70MP0005165_increased_susceptibility_to1.06601839
71MP0000604_amyloidosis1.04595620
72MP0001666_abnormal_nutrient_absorption1.03350606
73MP0005167_abnormal_blood-brain_barrier1.02204748
74MP0010155_abnormal_intestine_physiology0.99925037
75MP0002405_respiratory_system_inflammati0.99787683
76MP0000609_abnormal_liver_physiology0.99282212
77MP0003806_abnormal_nucleotide_metabolis0.99118042
78MP0005390_skeleton_phenotype0.98717727
79MP0001873_stomach_inflammation0.98586051
80MP0001819_abnormal_immune_cell0.98344726
81MP0002420_abnormal_adaptive_immunity0.98343779
82MP0008260_abnormal_autophagy0.98132253
83* MP0002136_abnormal_kidney_physiology0.97980576
84MP0000858_altered_metastatic_potential0.97469356
85MP0009384_cardiac_valve_regurgitation0.97148628
86MP0005621_abnormal_cell_physiology0.96380551
87MP0008469_abnormal_protein_level0.96347703
88MP0003183_abnormal_peptide_metabolism0.95832227
89MP0000762_abnormal_tongue_morphology0.95677039
90MP0001243_abnormal_dermal_layer0.95645767
91MP0004858_abnormal_nervous_system0.95446309
92MP0001853_heart_inflammation0.95173351
93MP0005166_decreased_susceptibility_to0.93981340
94MP0003941_abnormal_skin_development0.93476190
95MP0003950_abnormal_plasma_membrane0.93252728
96MP0002295_abnormal_pulmonary_circulatio0.92778319
97MP0009278_abnormal_bone_marrow0.92290902
98MP0003075_altered_response_to0.92098371
99MP0003045_fibrosis0.91857831
100MP0004510_myositis0.91692846
101MP0002166_altered_tumor_susceptibility0.91460463
102MP0010307_abnormal_tumor_latency0.91297125
103MP0000343_altered_response_to0.91283866
104MP0002168_other_aberrant_phenotype0.90901550
105MP0001915_intracranial_hemorrhage0.90187526
106MP0003828_pulmonary_edema0.90100366
107MP0010678_abnormal_skin_adnexa0.89306935
108MP0001216_abnormal_epidermal_layer0.89262730
109MP0004782_abnormal_surfactant_physiolog0.89200562
110MP0000733_abnormal_muscle_development0.89047100
111MP0005164_abnormal_response_to0.88416187
112MP0000249_abnormal_blood_vessel0.87887085
113MP0000569_abnormal_digit_pigmentation0.87656368
114MP0005503_abnormal_tendon_morphology0.86657806
115MP0000465_gastrointestinal_hemorrhage0.86394820
116MP0009764_decreased_sensitivity_to0.85682504
117MP0004185_abnormal_adipocyte_glucose0.84730053
118MP0001348_abnormal_lacrimal_gland0.84716273
119MP0005375_adipose_tissue_phenotype0.84268390
120MP0000371_diluted_coat_color0.82538588
121MP0000383_abnormal_hair_follicle0.81946637
122MP0005197_abnormal_uvea_morphology0.79962276
123MP0010771_integument_phenotype0.79297677
124MP0000467_abnormal_esophagus_morphology0.78459524
125MP0000490_abnormal_crypts_of0.78110600
126MP0004264_abnormal_extraembryonic_tissu0.72136257
127MP0005248_abnormal_Harderian_gland0.70078117
128MP0005595_abnormal_vascular_smooth0.69733023
129MP0000627_abnormal_mammary_gland0.69236796
130MP0001191_abnormal_skin_condition0.68748402
131MP0003868_abnormal_feces_composition0.68399934
132MP0000377_abnormal_hair_follicle0.68264409
133MP0001542_abnormal_bone_strength0.67832424
134MP0004808_abnormal_hematopoietic_stem0.66962511
135MP0002098_abnormal_vibrissa_morphology0.65998133
136MP0000537_abnormal_urethra_morphology0.65897629

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)4.08052078
2Abnormality of glycolipid metabolism (HP:0010969)3.55365973
3Abnormality of liposaccharide metabolism (HP:0010968)3.55365973
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.55365973
5Eczematoid dermatitis (HP:0000976)3.21465688
6Natal tooth (HP:0000695)3.07490970
7Premature rupture of membranes (HP:0001788)3.07394325
8Xanthomatosis (HP:0000991)3.05020757
9Recurrent gram-negative bacterial infections (HP:0005420)3.03706324
10Recurrent abscess formation (HP:0002722)2.96546077
11Deep venous thrombosis (HP:0002625)2.93666825
12Glomerulonephritis (HP:0000099)2.92338476
13Vacuolated lymphocytes (HP:0001922)2.91778237
14Systemic lupus erythematosus (HP:0002725)2.88471793
15Axonal loss (HP:0003447)2.87850617
16Arterial tortuosity (HP:0005116)2.87430618
17Spondylolisthesis (HP:0003302)2.80355144
18Nephritis (HP:0000123)2.74361985
19Recurrent bacterial skin infections (HP:0005406)2.73151117
20Vascular tortuosity (HP:0004948)2.71688503
21Increased cerebral lipofuscin (HP:0011813)2.71463959
22Protrusio acetabuli (HP:0003179)2.70439069
23Interstitial pulmonary disease (HP:0006530)2.69229417
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.67856503
25Osteolytic defects of the hand bones (HP:0009699)2.67856503
26Fragile skin (HP:0001030)2.62999493
27Hematochezia (HP:0002573)2.62839982
28Short nail (HP:0001799)2.62080755
29Intrahepatic cholestasis (HP:0001406)2.61422695
30Hyperacusis (HP:0010780)2.57673771
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55066938
32Aortic aneurysm (HP:0004942)2.53570841
33Esophageal varix (HP:0002040)2.53461213
34Milia (HP:0001056)2.51809078
35Wormian bones (HP:0002645)2.49993257
36Complement deficiency (HP:0004431)2.47031620
37Peritonitis (HP:0002586)2.46776628
38Cervical subluxation (HP:0003308)2.45733376
39Thin bony cortex (HP:0002753)2.43212925
40Tetraparesis (HP:0002273)2.42046208
41Nuclear cataract (HP:0100018)2.41831546
42Dysostosis multiplex (HP:0000943)2.41797449
43Malnutrition (HP:0004395)2.41572427
44Abnormality of complement system (HP:0005339)2.39374992
45Cerebral aneurysm (HP:0004944)2.36137170
46Autoimmune thrombocytopenia (HP:0001973)2.36040763
47Cupped ribs (HP:0000887)2.35388030
48Atrophic scars (HP:0001075)2.34035214
49Aortic dissection (HP:0002647)2.33759310
50Abnormality of macrophages (HP:0004311)2.30961884
51Thick nail (HP:0001805)2.28889514
52Mucopolysacchariduria (HP:0008155)2.28373329
53Urinary glycosaminoglycan excretion (HP:0003541)2.28373329
54Mitral stenosis (HP:0001718)2.25655624
55* Focal segmental glomerulosclerosis (HP:0000097)2.24670200
56Onycholysis (HP:0001806)2.23976733
57Broad face (HP:0000283)2.21721568
58Plantar hyperkeratosis (HP:0007556)2.21346623
59Ulnar bowing (HP:0003031)2.19227485
60Neurofibrillary tangles (HP:0002185)2.18383483
61Loss of speech (HP:0002371)2.17002926
62Distal lower limb amyotrophy (HP:0008944)2.16450924
63Achilles tendon contracture (HP:0001771)2.16268565
64Joint hemorrhage (HP:0005261)2.15801659
65Mesangial abnormality (HP:0001966)2.14637661
66Bladder diverticulum (HP:0000015)2.13631008
67Advanced eruption of teeth (HP:0006288)2.13516235
68Pustule (HP:0200039)2.12895390
69Elbow flexion contracture (HP:0002987)2.11960220
70Alopecia of scalp (HP:0002293)2.10293308
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08831090
72Abnormality of polysaccharide metabolism (HP:0011012)2.08831090
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08831090
74Hydroxyprolinuria (HP:0003080)2.08202001
75Abnormality of proline metabolism (HP:0010907)2.08202001
76Vertebral compression fractures (HP:0002953)2.07914884
77Hypoalphalipoproteinemia (HP:0003233)2.07427879
78Cellulitis (HP:0100658)2.07243836
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05979043
80Abnormal foot bone ossification (HP:0010675)2.04254883
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.04168615
82Gastrointestinal stroma tumor (HP:0100723)2.03712245
83Increased connective tissue (HP:0009025)2.03002689
84Abnormal tarsal ossification (HP:0008369)2.02256354
85Flat acetabular roof (HP:0003180)2.01714116
86Epidermoid cyst (HP:0200040)2.00580316
87Right ventricular cardiomyopathy (HP:0011663)2.00488634
88Mitral valve prolapse (HP:0001634)2.00003421
89Abnormality of the Achilles tendon (HP:0005109)1.98824806
90Tibial bowing (HP:0002982)1.97870331
91Selective tooth agenesis (HP:0001592)1.94600532
92Metaphyseal cupping (HP:0003021)1.93910252
93Hyperlipoproteinemia (HP:0010980)1.93654648
94Abnormality of nail color (HP:0100643)1.93209849
95Hypercholesterolemia (HP:0003124)1.92697398
96Abnormality of the distal phalanges of the toes (HP:0010182)1.92411862
97IgA deficiency (HP:0002720)1.91572627
98Colitis (HP:0002583)1.91044929
99Upper limb amyotrophy (HP:0009129)1.90784612
100Distal upper limb amyotrophy (HP:0007149)1.90784612
101Entropion (HP:0000621)1.90217085
102Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89886853
103Increased CSF protein (HP:0002922)1.89185452
104Cardiovascular calcification (HP:0011915)1.89157732
105Ovoid vertebral bodies (HP:0003300)1.89016505
106Abnormality of the acetabulum (HP:0003170)1.88784124
107Osteomyelitis (HP:0002754)1.88349757
108Persistence of primary teeth (HP:0006335)1.86583196
109Shallow orbits (HP:0000586)1.86368004
110Gingivitis (HP:0000230)1.85673220
111Increased mean platelet volume (HP:0011877)1.84415992
112Ridged nail (HP:0001807)1.84261375
113Periodontitis (HP:0000704)1.84059644
114Subacute progressive viral hepatitis (HP:0006572)1.83227483
115Mediastinal lymphadenopathy (HP:0100721)1.83036917
116Cerebral inclusion bodies (HP:0100314)1.82415324
117Protuberant abdomen (HP:0001538)1.82037714
118Abnormality of the lumbar spine (HP:0100712)1.81774435
119Distal lower limb muscle weakness (HP:0009053)1.81540089
120Ankle contracture (HP:0006466)1.80691898
121Emphysema (HP:0002097)1.79554629
122Nail dystrophy (HP:0008404)1.79352263
123Aneurysm (HP:0002617)1.79098413
124Vascular calcification (HP:0004934)1.77246172
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77196162
126Peripheral demyelination (HP:0011096)1.76333320
127Upper motor neuron abnormality (HP:0002127)1.75827596
128* Glomerulosclerosis (HP:0000096)1.74901892
129Epiphyseal dysplasia (HP:0002656)1.74416398
130Recurrent skin infections (HP:0001581)1.74283734
131Pathologic fracture (HP:0002756)1.74134135
132Abnormality of the common coagulation pathway (HP:0010990)1.74044004
133Bone pain (HP:0002653)1.73518589
134Ankyloglossia (HP:0010296)1.73230073
135Blue sclerae (HP:0000592)1.72296992
136Abnormal platelet volume (HP:0011876)1.72194184
137Palmoplantar hyperkeratosis (HP:0000972)1.71984892
138Spinal rigidity (HP:0003306)1.71695491
139Dilatation of the ascending aorta (HP:0005111)1.71686344
140Hypoplastic ischia (HP:0003175)1.71300858
141Neonatal short-limb short stature (HP:0008921)1.71160587
142Thoracolumbar scoliosis (HP:0002944)1.71012862
143Camptodactyly of toe (HP:0001836)1.70870147
144Polycythemia (HP:0001901)1.70658815
145Conjunctival telangiectasia (HP:0000524)1.70493230
146Femoral bowing (HP:0002980)1.70142906
147Disinhibition (HP:0000734)1.70028409
148Vasculitis (HP:0002633)1.68286364
149Disproportionate tall stature (HP:0001519)1.67905807
150Fat malabsorption (HP:0002630)1.67891576
151Abnormal ossification of hand bones (HP:0005921)1.66847078
152Abnormality of carpal bone ossification (HP:0006257)1.64204915
153Aortic regurgitation (HP:0001659)1.64006706
154Absent frontal sinuses (HP:0002688)1.63001753
155Abnormality of oral frenula (HP:0000190)1.62732257
156Mitral regurgitation (HP:0001653)1.62011259
157Abnormality of dentin (HP:0010299)1.60399854
158Vertebral arch anomaly (HP:0008438)1.60109083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.25924158
2TBK12.66165896
3TRIB32.31157782
4PRPF4B2.16399735
5NME22.16292653
6EPHB12.13953720
7TGFBR22.13182922
8MAP3K142.09689438
9LATS22.09045971
10EEF2K2.06515363
11SMG11.96552039
12MST41.96132937
13STK101.93524185
14FGFR41.92102868
15TYK21.90743468
16MAP4K11.88957196
17TTN1.87848717
18EPHA21.86818508
19IRAK31.85462275
20MST1R1.81723177
21LATS11.81660683
22LRRK21.76467838
23PDK21.75243931
24NEK91.74312513
25MAP3K31.70227665
26PTK61.68850770
27RIPK11.68673761
28SIK11.64274599
29JAK11.64007863
30ICK1.62723437
31BLK1.61348447
32KIT1.55662563
33MOS1.47556541
34CDK121.47040924
35IKBKB1.44911987
36CDC42BPA1.43961414
37EPHA31.42653600
38DDR21.37440066
39STK31.34495744
40CSK1.33898997
41MAP3K91.33542447
42IKBKE1.33116772
43FGFR31.32055055
44FRK1.29845291
45MET1.27120175
46CAMK1D1.24641352
47RIPK41.24569221
48TRPM71.20949368
49CSF1R1.20088123
50EPHB21.19476047
51BMX1.19295653
52ARAF1.18853882
53CHUK1.15174165
54PKN21.14007855
55LMTK21.11965124
56PIM21.09841715
57JAK31.09729797
58PBK1.09052051
59MELK1.09038021
60FER1.02323607
61MATK1.02163128
62PDGFRA1.02016036
63PAK41.01528309
64RPS6KA40.97093003
65MAP3K100.95845852
66MAP2K30.94201131
67GRK60.92377737
68PTK20.90992151
69CDK60.90336499
70TAOK20.89348634
71MAP3K20.86784762
72KDR0.86484291
73HCK0.86432018
74ACVR1B0.79155877
75MAPK110.79021123
76PDGFRB0.78125933
77PIM10.78076979
78DMPK0.77344159
79PRKG20.74722828
80MARK30.73954705
81ITK0.72853619
82EGFR0.72802007
83JAK20.69960551
84MAP2K20.69311194
85TAOK30.69298361
86PAK20.68909050
87MTOR0.66768686
88GSK3A0.66462261
89BRD40.66076358
90ERBB40.65119892
91ABL10.63187901
92EIF2AK30.61867036
93FGR0.61796515
94FGFR20.60626216
95CAMK1G0.60502750
96MAP3K80.59742263
97BMPR20.59192008
98ZAP700.58857060
99RPS6KA20.56781674
100MAP3K130.56654484
101MAP2K10.56120691
102LIMK10.54898936
103CDK90.53562401
104MAPK70.52851720
105TESK10.52147600
106PDPK10.51540544
107LYN0.51202393
108INSR0.50962031
109IGF1R0.50563901
110BTK0.50366095
111DYRK1B0.50232546
112LCK0.49947500
113STK38L0.49024569
114ABL20.48586224
115ERBB20.46150310
116NEK10.45723036
117SCYL20.45434403
118MAPKAPK20.45195501
119RPS6KB20.45151062
120PIK3CA0.44830254
121MYLK0.44655370
122PIK3CG0.44455707
123MAPKAPK30.44393368
124PRKD10.44271929
125TGFBR10.43838790
126MAP3K10.43396543
127SYK0.43262127
128STK240.42528390
129KSR20.42309246
130NTRK10.42150956
131MAPKAPK50.40062895
132DAPK30.39854275
133ROCK20.33150081
134BRAF0.32713871
135CDK40.31107146
136TTK0.30812292
137IRAK40.28431188

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.76407776
2Complement and coagulation cascades_Homo sapiens_hsa046102.46935567
3Primary bile acid biosynthesis_Homo sapiens_hsa001201.89590491
4Leishmaniasis_Homo sapiens_hsa051401.86785139
5Galactose metabolism_Homo sapiens_hsa000521.80034805
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.78680689
7ECM-receptor interaction_Homo sapiens_hsa045121.75825147
8Lysosome_Homo sapiens_hsa041421.73683783
9Nitrogen metabolism_Homo sapiens_hsa009101.72701786
10Fructose and mannose metabolism_Homo sapiens_hsa000511.71079755
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70819675
12B cell receptor signaling pathway_Homo sapiens_hsa046621.69904543
13Malaria_Homo sapiens_hsa051441.64311833
14Caffeine metabolism_Homo sapiens_hsa002321.62614566
15Osteoclast differentiation_Homo sapiens_hsa043801.61633400
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54963905
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.52495834
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52304766
19Steroid biosynthesis_Homo sapiens_hsa001001.50217333
20Pertussis_Homo sapiens_hsa051331.44808847
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39078925
22Amoebiasis_Homo sapiens_hsa051461.37898260
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.35674692
24Tuberculosis_Homo sapiens_hsa051521.31066510
25Arginine biosynthesis_Homo sapiens_hsa002201.30905778
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.30846336
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30787933
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28681395
29Toxoplasmosis_Homo sapiens_hsa051451.27246055
30Adherens junction_Homo sapiens_hsa045201.26752283
31Focal adhesion_Homo sapiens_hsa045101.25552117
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22626835
33Pentose phosphate pathway_Homo sapiens_hsa000301.19328456
34Prion diseases_Homo sapiens_hsa050201.19226219
35Phagosome_Homo sapiens_hsa041451.17939597
36Small cell lung cancer_Homo sapiens_hsa052221.17802208
37Proteoglycans in cancer_Homo sapiens_hsa052051.17111485
38PPAR signaling pathway_Homo sapiens_hsa033201.16757197
39Allograft rejection_Homo sapiens_hsa053301.15566707
40Renin-angiotensin system_Homo sapiens_hsa046141.12087011
41Asthma_Homo sapiens_hsa053101.11207864
42Legionellosis_Homo sapiens_hsa051341.07977783
43Apoptosis_Homo sapiens_hsa042101.06794678
44Other glycan degradation_Homo sapiens_hsa005111.06163179
45Systemic lupus erythematosus_Homo sapiens_hsa053221.05924576
46Hematopoietic cell lineage_Homo sapiens_hsa046401.05633732
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04814170
48Histidine metabolism_Homo sapiens_hsa003401.04592080
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04010495
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03720985
51TNF signaling pathway_Homo sapiens_hsa046681.03658695
52Tryptophan metabolism_Homo sapiens_hsa003801.03175245
53Salmonella infection_Homo sapiens_hsa051321.01355313
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99384344
55Pancreatic cancer_Homo sapiens_hsa052120.96351751
56Shigellosis_Homo sapiens_hsa051310.95443658
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95228457
58Hepatitis C_Homo sapiens_hsa051600.92176238
59Bladder cancer_Homo sapiens_hsa052190.92006682
60Antigen processing and presentation_Homo sapiens_hsa046120.90978042
61Measles_Homo sapiens_hsa051620.88437853
62Chronic myeloid leukemia_Homo sapiens_hsa052200.87961725
63Autoimmune thyroid disease_Homo sapiens_hsa053200.87700732
64Graft-versus-host disease_Homo sapiens_hsa053320.87243870
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86659239
66Mineral absorption_Homo sapiens_hsa049780.85139008
67Influenza A_Homo sapiens_hsa051640.83849729
68Chemical carcinogenesis_Homo sapiens_hsa052040.82904911
69Fatty acid degradation_Homo sapiens_hsa000710.82825569
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82793313
71Viral myocarditis_Homo sapiens_hsa054160.82104869
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81535392
73Bile secretion_Homo sapiens_hsa049760.81407988
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.79619639
75Protein digestion and absorption_Homo sapiens_hsa049740.78946111
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78667170
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78429743
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78029061
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76357284
80MicroRNAs in cancer_Homo sapiens_hsa052060.76111480
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74537180
82Hepatitis B_Homo sapiens_hsa051610.74123908
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74047001
84Herpes simplex infection_Homo sapiens_hsa051680.73875682
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73095270
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73053094
87Starch and sucrose metabolism_Homo sapiens_hsa005000.72031726
88Thyroid cancer_Homo sapiens_hsa052160.70893072
89Fat digestion and absorption_Homo sapiens_hsa049750.68748749
90Notch signaling pathway_Homo sapiens_hsa043300.68283762
91ABC transporters_Homo sapiens_hsa020100.68172543
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67728082
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.67441252
94Biosynthesis of amino acids_Homo sapiens_hsa012300.66481571
95HIF-1 signaling pathway_Homo sapiens_hsa040660.66193826
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66003840
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.65054553
98Retinol metabolism_Homo sapiens_hsa008300.63970939
99Platelet activation_Homo sapiens_hsa046110.63480252
100Rheumatoid arthritis_Homo sapiens_hsa053230.62936496
101Insulin resistance_Homo sapiens_hsa049310.61794914
102Lysine degradation_Homo sapiens_hsa003100.61256078
103Dorso-ventral axis formation_Homo sapiens_hsa043200.60256086
104Vitamin digestion and absorption_Homo sapiens_hsa049770.59761378
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58381870
106p53 signaling pathway_Homo sapiens_hsa041150.57989785
107Prostate cancer_Homo sapiens_hsa052150.57155099
108HTLV-I infection_Homo sapiens_hsa051660.56443622
109Acute myeloid leukemia_Homo sapiens_hsa052210.55538156
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55207895
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54682708
112Pathways in cancer_Homo sapiens_hsa052000.53721088
113Sulfur metabolism_Homo sapiens_hsa009200.52786108
114Vibrio cholerae infection_Homo sapiens_hsa051100.52550683
115Sphingolipid metabolism_Homo sapiens_hsa006000.51441675
116Tight junction_Homo sapiens_hsa045300.49243579
117African trypanosomiasis_Homo sapiens_hsa051430.47789556
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.47621538
119Chemokine signaling pathway_Homo sapiens_hsa040620.47552305
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47530304
121TGF-beta signaling pathway_Homo sapiens_hsa043500.46377831
122ErbB signaling pathway_Homo sapiens_hsa040120.46055070
123Primary immunodeficiency_Homo sapiens_hsa053400.44959282
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.44652373
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.43911850
126Endocytosis_Homo sapiens_hsa041440.43818859
127Phenylalanine metabolism_Homo sapiens_hsa003600.43064721
128Viral carcinogenesis_Homo sapiens_hsa052030.42897308
129Renal cell carcinoma_Homo sapiens_hsa052110.42796266

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »