MYO1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.99299501
2modulation by symbiont of host defense response (GO:0052031)5.99299501
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.99299501
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.99299501
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.99299501
6modulation by symbiont of host immune response (GO:0052553)5.99299501
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59703606
8regulation of B cell receptor signaling pathway (GO:0050855)5.24420544
9negative regulation of cell killing (GO:0031342)5.15459015
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15459015
11regulation of interferon-beta biosynthetic process (GO:0045357)5.09439813
12respiratory burst (GO:0045730)5.00777431
13detection of bacterium (GO:0016045)4.97739472
14leukocyte aggregation (GO:0070486)4.97251855
15neutrophil mediated immunity (GO:0002446)4.92313302
16positive regulation of gamma-delta T cell activation (GO:0046645)4.83431763
17response to peptidoglycan (GO:0032494)4.73461953
18immunoglobulin mediated immune response (GO:0016064)4.65621961
19detection of external biotic stimulus (GO:0098581)4.44196109
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.44124061
21macrophage activation involved in immune response (GO:0002281)4.43584880
22* neutrophil activation involved in immune response (GO:0002283)4.41436963
23cellular extravasation (GO:0045123)4.32532862
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.32322607
25detection of molecule of bacterial origin (GO:0032490)4.29598299
26response to host immune response (GO:0052572)4.22484489
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22484489
28response to interleukin-15 (GO:0070672)4.15837579
29positive regulation of mast cell activation (GO:0033005)4.14639422
30positive regulation of interferon-alpha production (GO:0032727)4.14192057
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.96386510
32negative regulation of leukocyte mediated immunity (GO:0002704)3.95941175
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.92655291
34regulation of interferon-alpha production (GO:0032647)3.91866837
35detection of biotic stimulus (GO:0009595)3.91675683
36response to host defenses (GO:0052200)3.88392863
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.88392863
38response to host (GO:0075136)3.88392863
39cellular response to interleukin-15 (GO:0071350)3.82435676
40negative regulation of T cell mediated immunity (GO:0002710)3.81988986
41regulation of mast cell activation (GO:0033003)3.81615053
42regulation of mast cell degranulation (GO:0043304)3.81102420
43positive regulation of B cell differentiation (GO:0045579)3.78191092
44myeloid leukocyte mediated immunity (GO:0002444)3.78003302
45production of molecular mediator involved in inflammatory response (GO:0002532)3.73282035
46positive regulation of antigen processing and presentation (GO:0002579)3.68363740
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67767089
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67767089
49response to muramyl dipeptide (GO:0032495)3.65874847
50leukocyte migration involved in inflammatory response (GO:0002523)3.64887580
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.64215061
52* myeloid cell activation involved in immune response (GO:0002275)3.59872246
53* neutrophil activation (GO:0042119)3.59582978
54regulation of mast cell activation involved in immune response (GO:0033006)3.58154611
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58065606
56natural killer cell mediated immunity (GO:0002228)3.57775812
57natural killer cell mediated cytotoxicity (GO:0042267)3.57775812
58Arp2/3 complex-mediated actin nucleation (GO:0034314)3.56030018
59regulation of B cell differentiation (GO:0045577)3.53801613
60* granulocyte activation (GO:0036230)3.53591384
61antigen processing and presentation via MHC class Ib (GO:0002475)3.50496010
62leukocyte mediated cytotoxicity (GO:0001909)3.47884181
63B cell mediated immunity (GO:0019724)3.47109440
64regulation of T cell tolerance induction (GO:0002664)3.46785913
65antigen processing and presentation of endogenous antigen (GO:0019883)3.43868306
66microglial cell activation (GO:0001774)3.41492860
67pinocytosis (GO:0006907)3.40519347
68regulation of tolerance induction (GO:0002643)3.40380711
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34659885
70regulation of leukocyte degranulation (GO:0043300)3.34442403
71activated T cell proliferation (GO:0050798)3.34397340
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.33463690
73positive regulation of mast cell degranulation (GO:0043306)3.33463690
74negative thymic T cell selection (GO:0045060)3.33000758
75negative regulation of erythrocyte differentiation (GO:0045647)3.31471634
76regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31036340
77defense response to protozoan (GO:0042832)3.29742921
78B cell receptor signaling pathway (GO:0050853)3.26780248
79negative T cell selection (GO:0043383)3.25097683
80neutrophil chemotaxis (GO:0030593)3.22518980
81leukocyte cell-cell adhesion (GO:0007159)3.22407360
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21197050
83regulation of gamma-delta T cell activation (GO:0046643)3.19071722
84positive regulation of interferon-beta production (GO:0032728)3.16679645
85response to fungus (GO:0009620)3.16461306
86regulation of gamma-delta T cell differentiation (GO:0045586)3.14352709
87negative regulation of interleukin-12 production (GO:0032695)3.14215906
88neutrophil migration (GO:1990266)3.13139145
89regulation of antigen processing and presentation (GO:0002577)3.11846630
90negative regulation of phagocytosis (GO:0050765)3.11649541
91macrophage activation (GO:0042116)3.11522050
92regulation of T cell mediated cytotoxicity (GO:0001914)3.10897381
93cellular response to zinc ion (GO:0071294)3.10772443
94hydrogen peroxide biosynthetic process (GO:0050665)3.10742308
95reactive oxygen species biosynthetic process (GO:1903409)3.09093571
96superoxide anion generation (GO:0042554)3.08846544
97regulation of regulated secretory pathway (GO:1903305)3.07642896
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.04457949
99regulation of natural killer cell mediated immunity (GO:0002715)3.04457949
100regulation of interleukin-8 biosynthetic process (GO:0045414)3.03400580
101response to protozoan (GO:0001562)3.02156596
102positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02108946
103dendritic cell migration (GO:0036336)3.01966042
104negative regulation of innate immune response (GO:0045824)3.00783502
105lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00769286
106tolerance induction (GO:0002507)3.00242212
107T cell migration (GO:0072678)2.97630027
108regulation of T-helper 2 cell differentiation (GO:0045628)2.97193730
109negative regulation of cytokine production involved in immune response (GO:0002719)2.96167187
110dendritic cell chemotaxis (GO:0002407)2.94923877
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94702035
112regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94654725
113regulation of alpha-beta T cell proliferation (GO:0046640)2.94394520
114negative regulation of type 2 immune response (GO:0002829)2.93944154
115interferon-gamma-mediated signaling pathway (GO:0060333)2.92535278
116actin nucleation (GO:0045010)2.91077490
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90490538
118negative regulation of mast cell activation (GO:0033004)2.89638361
119mast cell activation (GO:0045576)2.87719469
120detection of other organism (GO:0098543)2.87554515
121positive thymic T cell selection (GO:0045059)2.84822978
122cellular response to type I interferon (GO:0071357)2.77776636
123type I interferon signaling pathway (GO:0060337)2.77776636
124germinal center formation (GO:0002467)2.77339383
125response to type I interferon (GO:0034340)2.77218459
126leukocyte mediated immunity (GO:0002443)2.76833454
127* myeloid leukocyte activation (GO:0002274)2.76625458
128positive regulation of leukocyte degranulation (GO:0043302)2.75791744
129lymphocyte mediated immunity (GO:0002449)2.75520637
130positive regulation of cellular amide metabolic process (GO:0034250)2.75222899
131leukotriene metabolic process (GO:0006691)2.74200299
132negative regulation of interleukin-6 production (GO:0032715)2.74130702
133myeloid dendritic cell activation (GO:0001773)2.74025114
134granulocyte chemotaxis (GO:0071621)2.73944392
135negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73859953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.95803888
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.61650811
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.31989004
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.12212336
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.09458669
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.96172933
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63368370
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51420000
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.49597261
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25971186
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21045117
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.19962303
13E2F7_22180533_ChIP-Seq_HELA_Human3.04983156
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.96015813
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85597193
16SPI1_23547873_ChIP-Seq_NB4_Human2.68331970
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68116750
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68063671
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.65223596
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57442034
21SCL_19346495_ChIP-Seq_HPC-7_Human2.54166580
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49174955
23VDR_21846776_ChIP-Seq_THP-1_Human2.45351386
24* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35746259
25SPI1_23127762_ChIP-Seq_K562_Human2.26409566
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.22414112
27VDR_24763502_ChIP-Seq_THP-1_Human2.20224541
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08743171
29* MYB_26560356_Chip-Seq_TH2_Human2.07198604
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05397460
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04694114
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03084314
33MAF_26560356_Chip-Seq_TH1_Human2.00120004
34RUNX_20019798_ChIP-Seq_JUKART_Human1.92292717
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.90481696
36PU_27001747_Chip-Seq_BMDM_Mouse1.88704621
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87655996
38MYB_26560356_Chip-Seq_TH1_Human1.83861582
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81089991
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78002543
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75770784
42MYC_22102868_ChIP-Seq_BL_Human1.69589936
43UTX_26944678_Chip-Seq_JUKART_Human1.66390122
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62494997
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61463500
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61451980
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.57413915
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55850254
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.54381615
50TCF7_22412390_ChIP-Seq_EML_Mouse1.51485326
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47932596
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47778513
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43423570
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40708194
55VDR_24787735_ChIP-Seq_THP-1_Human1.39487721
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37665776
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35460002
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.34504494
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30878264
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29686039
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29550292
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29250969
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25090640
64TFEB_21752829_ChIP-Seq_HELA_Human1.24840154
65GATA3_26560356_Chip-Seq_TH2_Human1.22790659
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22070646
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20567937
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19717945
69* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19171834
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.17153220
71* MAF_26560356_Chip-Seq_TH2_Human1.16058426
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.15172478
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14614484
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13698589
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12809946
76GATA1_22025678_ChIP-Seq_K562_Human1.12105155
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11798480
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07423958
79* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06741095
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05965024
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03681132
82BCOR_27268052_Chip-Seq_Bcells_Human1.03324191
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03242046
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99322101
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98226952
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97090544
87KDM2B_26808549_Chip-Seq_DND41_Human0.96970857
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96896589
89ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91657984
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91108836
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90678247
92* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86508740
93GATA2_19941826_ChIP-Seq_K562_Human0.85911501
94SPI1_20517297_ChIP-Seq_HL60_Human0.84921872
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84286954
96GATA1_19941826_ChIP-Seq_K562_Human0.82081802
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79850441
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76647998
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76104480
100* SA1_27219007_Chip-Seq_ERYTHROID_Human0.75888090
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.75734066
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74697492
103* LXR_22292898_ChIP-Seq_THP-1_Human0.71206800
104NCOR1_26117541_ChIP-Seq_K562_Human0.66959974
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.65104925
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64600372
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.64511428
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64423751
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63862643
110BCL6_27268052_Chip-Seq_Bcells_Human0.61619839
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59953017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03522958
2MP0003436_decreased_susceptibility_to3.69410376
3MP0005058_abnormal_lysosome_morphology3.68125088
4MP0000569_abnormal_digit_pigmentation3.45550264
5MP0003303_peritoneal_inflammation3.25662189
6* MP0002419_abnormal_innate_immunity3.23543500
7MP0003172_abnormal_lysosome_physiology3.18296905
8MP0009785_altered_susceptibility_to3.08153066
9MP0006082_CNS_inflammation2.94392803
10MP0005000_abnormal_immune_tolerance2.86184085
11MP0005025_abnormal_response_to2.80667296
12MP0002452_abnormal_antigen_presenting2.65575658
13MP0005671_abnormal_response_to2.65431615
14MP0001800_abnormal_humoral_immune2.58857320
15MP0005387_immune_system_phenotype2.53758376
16MP0001790_abnormal_immune_system2.53758376
17MP0002148_abnormal_hypersensitivity_rea2.52218409
18MP0005464_abnormal_platelet_physiology2.47528944
19MP0000685_abnormal_immune_system2.47328613
20MP0002723_abnormal_immune_serum2.46228657
21* MP0001819_abnormal_immune_cell2.40396540
22* MP0002420_abnormal_adaptive_immunity2.39724012
23MP0009278_abnormal_bone_marrow2.26874266
24MP0003724_increased_susceptibility_to2.13190838
25MP0005174_abnormal_tail_pigmentation2.10356497
26MP0002405_respiratory_system_inflammati2.08928713
27MP0003183_abnormal_peptide_metabolism2.07020945
28MP0004510_myositis1.98382007
29MP0001533_abnormal_skeleton_physiology1.91524267
30MP0002132_abnormal_respiratory_system1.84533102
31MP0002398_abnormal_bone_marrow1.82812013
32MP0000716_abnormal_immune_system1.81912757
33MP0001845_abnormal_inflammatory_respons1.80098374
34MP0004947_skin_inflammation1.78889918
35MP0003300_gastrointestinal_ulcer1.78706661
36MP0001853_heart_inflammation1.72575619
37MP0002166_altered_tumor_susceptibility1.72367601
38MP0002396_abnormal_hematopoietic_system1.69673536
39MP0003448_altered_tumor_morphology1.68997472
40MP0000689_abnormal_spleen_morphology1.68215370
41MP0005397_hematopoietic_system_phenotyp1.66711502
42MP0001545_abnormal_hematopoietic_system1.66711502
43MP0003191_abnormal_cellular_cholesterol1.64985283
44MP0000858_altered_metastatic_potential1.63758195
45MP0002006_tumorigenesis1.54268765
46MP0002722_abnormal_immune_system1.53858768
47MP0009840_abnormal_foam_cell1.53841732
48MP0000015_abnormal_ear_pigmentation1.53189324
49MP0000465_gastrointestinal_hemorrhage1.52552187
50MP0000343_altered_response_to1.51862799
51MP0002429_abnormal_blood_cell1.51194587
52MP0008469_abnormal_protein_level1.49455594
53MP0010155_abnormal_intestine_physiology1.49381543
54MP0004381_abnormal_hair_follicle1.47742527
55MP0005451_abnormal_body_composition1.47472417
56MP0009333_abnormal_splenocyte_physiolog1.45758690
57MP0010307_abnormal_tumor_latency1.41525673
58MP0003763_abnormal_thymus_physiology1.41386539
59MP0001851_eye_inflammation1.39892186
60MP0001873_stomach_inflammation1.37590873
61MP0003075_altered_response_to1.35045751
62MP0005310_abnormal_salivary_gland1.32765628
63MP0000604_amyloidosis1.27298380
64MP0004808_abnormal_hematopoietic_stem1.25014553
65MP0002933_joint_inflammation1.24887370
66MP0009764_decreased_sensitivity_to1.23316096
67MP0002998_abnormal_bone_remodeling1.21889072
68MP0003690_abnormal_glial_cell1.13503339
69MP0005166_decreased_susceptibility_to1.10094721
70MP0005167_abnormal_blood-brain_barrier1.09851489
71MP0001958_emphysema1.05768181
72MP0000703_abnormal_thymus_morphology1.05219317
73MP0000371_diluted_coat_color1.03637059
74MP0009763_increased_sensitivity_to0.95412850
75MP0000490_abnormal_crypts_of0.94268643
76MP0005076_abnormal_cell_differentiation0.92588712
77MP0001986_abnormal_taste_sensitivity0.90725447
78MP0003656_abnormal_erythrocyte_physiolo0.90511675
79MP0003828_pulmonary_edema0.84147511
80MP0005257_abnormal_intraocular_pressure0.82238425
81MP0005390_skeleton_phenotype0.80923577
82MP0003866_abnormal_defecation0.80577969
83MP0008004_abnormal_stomach_pH0.79386405
84MP0002277_abnormal_respiratory_mucosa0.79170117
85MP0008260_abnormal_autophagy0.78919119
86MP0005075_abnormal_melanosome_morpholog0.78180627
87MP0003045_fibrosis0.74971383
88MP0003806_abnormal_nucleotide_metabolis0.72849502
89MP0004130_abnormal_muscle_cell0.69205898
90MP0000249_abnormal_blood_vessel0.68795853
91MP0003795_abnormal_bone_structure0.68065932
92MP0009765_abnormal_xenobiotic_induced0.66870541
93MP0005023_abnormal_wound_healing0.66622495
94* MP0003566_abnormal_cell_adhesion0.66204399
95MP0002019_abnormal_tumor_incidence0.65823470
96MP0005164_abnormal_response_to0.64042054
97MP0008874_decreased_physiological_sensi0.61940430
98MP0002095_abnormal_skin_pigmentation0.61642041
99MP0003221_abnormal_cardiomyocyte_apopto0.57874196
100MP0001663_abnormal_digestive_system0.56939268
101MP0003091_abnormal_cell_migration0.55635034
102MP0002138_abnormal_hepatobiliary_system0.54128214
103MP0005319_abnormal_enzyme/_coenzyme0.54052687
104MP0000920_abnormal_myelination0.53564648
105MP0002133_abnormal_respiratory_system0.53345188
106MP0005388_respiratory_system_phenotype0.53345188
107MP0005377_hearing/vestibular/ear_phenot0.51733916
108MP0003878_abnormal_ear_physiology0.51733916
109MP0002332_abnormal_exercise_endurance0.51245145
110MP0002136_abnormal_kidney_physiology0.48458708
111MP0004883_abnormal_blood_vessel0.48255727
112MP0004782_abnormal_surfactant_physiolog0.45832894
113MP0003279_aneurysm0.45717294
114MP0003453_abnormal_keratinocyte_physiol0.45331985
115MP0000598_abnormal_liver_morphology0.44857346
116MP0008873_increased_physiological_sensi0.44587038
117MP0010352_gastrointestinal_tract_polyps0.44295741
118MP0000767_abnormal_smooth_muscle0.43852354

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.92356955
2Recurrent bacterial skin infections (HP:0005406)6.93956129
3Eczematoid dermatitis (HP:0000976)6.63675838
4Recurrent gram-negative bacterial infections (HP:0005420)5.81398315
5Increased cerebral lipofuscin (HP:0011813)5.26434835
6Abnormality of macrophages (HP:0004311)5.10015404
7Vacuolated lymphocytes (HP:0001922)5.07903441
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.58209727
9Chronic obstructive pulmonary disease (HP:0006510)4.38673505
10Obstructive lung disease (HP:0006536)4.38673505
11Gingivitis (HP:0000230)4.37701477
12Recurrent skin infections (HP:0001581)4.35698447
13Mediastinal lymphadenopathy (HP:0100721)4.34797124
14Gastrointestinal infarctions (HP:0005244)4.27867245
15Myositis (HP:0100614)4.17700944
16Recurrent fungal infections (HP:0002841)4.05383633
17Elevated erythrocyte sedimentation rate (HP:0003565)3.98911358
18Encephalitis (HP:0002383)3.79331604
19Stomatitis (HP:0010280)3.69862111
20Hypochromic microcytic anemia (HP:0004840)3.67070298
21Abnormality of liposaccharide metabolism (HP:0010968)3.63938209
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.63938209
23Abnormality of glycolipid metabolism (HP:0010969)3.63938209
24Increased IgE level (HP:0003212)3.62755171
25Dysostosis multiplex (HP:0000943)3.57490265
26Autoimmune thrombocytopenia (HP:0001973)3.55488804
27Keratoconjunctivitis (HP:0001096)3.47852854
28Periodontitis (HP:0000704)3.39887277
29Systemic lupus erythematosus (HP:0002725)3.37042567
30Disinhibition (HP:0000734)3.34524321
31Orchitis (HP:0100796)3.30649066
32Hypochromic anemia (HP:0001931)3.29851460
33Recurrent cutaneous fungal infections (HP:0011370)3.14188287
34Chronic mucocutaneous candidiasis (HP:0002728)3.14188287
35Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.12207827
36Episodic fever (HP:0001954)3.12142776
37Recurrent viral infections (HP:0004429)3.10573795
38Spontaneous hematomas (HP:0007420)3.04680439
39Optic neuritis (HP:0100653)3.00893411
40Retrobulbar optic neuritis (HP:0100654)3.00893411
41Axonal loss (HP:0003447)2.98320881
42Cellulitis (HP:0100658)2.97496382
43Pustule (HP:0200039)2.97338315
44Meningitis (HP:0001287)2.93885076
45Mucopolysacchariduria (HP:0008155)2.90342611
46Urinary glycosaminoglycan excretion (HP:0003541)2.90342611
47Agnosia (HP:0010524)2.87574278
48Vasculitis (HP:0002633)2.87393919
49Urticaria (HP:0001025)2.85613877
50Loss of speech (HP:0002371)2.85132968
51Abnormality of polysaccharide metabolism (HP:0011012)2.83793481
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83793481
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83793481
54Amyloidosis (HP:0011034)2.81534364
55Peritonitis (HP:0002586)2.76872315
56Leukocytosis (HP:0001974)2.76111828
57Panhypogammaglobulinemia (HP:0003139)2.72429512
58Anorexia (HP:0002039)2.72422293
59Pulmonary embolism (HP:0002204)2.72262632
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60488305
61Hematochezia (HP:0002573)2.58605100
62Osteomyelitis (HP:0002754)2.58477995
63Prostate neoplasm (HP:0100787)2.57746809
64Hepatosplenomegaly (HP:0001433)2.57372433
65Increased IgM level (HP:0003496)2.53896102
66Microcytic anemia (HP:0001935)2.48459900
67Gingival bleeding (HP:0000225)2.42218432
68IgM deficiency (HP:0002850)2.40197969
69Epistaxis (HP:0000421)2.38238582
70Glomerulonephritis (HP:0000099)2.37384033
71Prolonged bleeding time (HP:0003010)2.37310872
72Hemoptysis (HP:0002105)2.36933780
73Chronic otitis media (HP:0000389)2.36575133
74Basal ganglia calcification (HP:0002135)2.36289622
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33583630
76T lymphocytopenia (HP:0005403)2.30232241
77Thoracic kyphosis (HP:0002942)2.29752682
78Inflammation of the large intestine (HP:0002037)2.29729980
79Abnormality of T cell number (HP:0011839)2.29639473
80Pulmonary infiltrates (HP:0002113)2.29022789
81Abnormality of the pleura (HP:0002103)2.28548154
82Lymphopenia (HP:0001888)2.26888948
83Petechiae (HP:0000967)2.26410750
84Abnormality of T cell physiology (HP:0011840)2.26265118
85Gangrene (HP:0100758)2.26048304
86Recurrent pneumonia (HP:0006532)2.25735612
87Upper motor neuron abnormality (HP:0002127)2.25561297
88Abnormality of the prostate (HP:0008775)2.22072113
89Hypergammaglobulinemia (HP:0010702)2.21626988
90Interstitial pulmonary disease (HP:0006530)2.21514771
91Eosinophilia (HP:0001880)2.21073688
92Thyroiditis (HP:0100646)2.19031198
93Gastrointestinal inflammation (HP:0004386)2.16830930
94Arterial thrombosis (HP:0004420)2.16689555
95Purpura (HP:0000979)2.15795090
96Abnormality of the peritoneum (HP:0002585)2.14236288
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.13822489
98Pathologic fracture (HP:0002756)2.10858364
99Glomerulopathy (HP:0100820)2.10453556
100Increased serum ferritin (HP:0003281)2.10090334
101Thick nail (HP:0001805)2.09268955
102Abnormality of the endocardium (HP:0004306)2.08121670
103Colitis (HP:0002583)2.05951253
104Slow saccadic eye movements (HP:0000514)2.05763933
105Abnormal delayed hypersensitivity skin test (HP:0002963)2.04200091
106Abnormality of eosinophils (HP:0001879)2.02749777
107Abnormality of iron homeostasis (HP:0011031)2.01853418
108Premature loss of primary teeth (HP:0006323)2.01091270
109Acne (HP:0001061)2.00265796
110Abnormal platelet function (HP:0011869)1.99316118
111Impaired platelet aggregation (HP:0003540)1.99316118
112Vertigo (HP:0002321)1.99057920
113Chest pain (HP:0100749)1.98737738
114Abnormality of the nasal mucosa (HP:0000433)1.98596268
115Thrombocytosis (HP:0001894)1.98269174
116Sepsis (HP:0100806)1.97698605
117Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97572941
118Abnormality of the thoracic spine (HP:0100711)1.96308835
119Abnormal platelet volume (HP:0011876)1.96253203
120Keratitis (HP:0000491)1.94205873
121Abnormality of T cells (HP:0002843)1.93317425
122Granulocytopenia (HP:0001913)1.93241224
123Keratoconjunctivitis sicca (HP:0001097)1.93073138
124Myocardial infarction (HP:0001658)1.92489364
125Skin ulcer (HP:0200042)1.92057033
126J-shaped sella turcica (HP:0002680)1.91519116
127Acute hepatic failure (HP:0006554)1.90847925
128Nasal polyposis (HP:0100582)1.90348245
129Abnormality of the pericardium (HP:0001697)1.90271459
130Viral hepatitis (HP:0006562)1.90028109
131Restrictive lung disease (HP:0002091)1.88833697
132Agammaglobulinemia (HP:0004432)1.88103767
133Polyneuropathy (HP:0001271)1.87762099
134Recurrent lower respiratory tract infections (HP:0002783)1.87538048
135Abnormality of the lumbar spine (HP:0100712)1.87109286
136Joint hemorrhage (HP:0005261)1.81496236
137Spondylolisthesis (HP:0003302)1.80827071
138Osteolytic defects of the hand bones (HP:0009699)1.79493102
139Autoimmune hemolytic anemia (HP:0001890)1.78068964
140Cheilitis (HP:0100825)1.75296898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.78359761
2MAP4K13.70230552
3IRAK43.69534075
4BLK3.25055052
5KIT3.00098595
6TYK22.70704704
7MAP3K142.62443875
8TBK12.60259808
9TXK2.47560798
10IRAK32.22103517
11FES2.21411612
12PRPF4B2.18728121
13ZAP702.17861595
14TAOK32.14154000
15CSK2.05470860
16JAK31.98892408
17BTK1.90751017
18TEC1.90322896
19ERN11.89206881
20IKBKE1.88619878
21TAOK11.87903734
22CSF1R1.87354842
23TGFBR21.86807253
24HCK1.84741191
25MAP2K31.79029065
26STK101.76242466
27JAK11.71726936
28SYK1.67488572
29ITK1.63155255
30CLK11.51745317
31IKBKB1.50249648
32FGR1.49695491
33NEK91.46159354
34MAP3K131.45061971
35LCK1.42391849
36TTN1.41467756
37EPHB11.39792500
38SIK21.32638420
39SIK31.31544960
40LYN1.27423964
41MAP3K11.24823119
42KSR21.20895513
43NME21.20086351
44CAMK1D1.15674801
45TRPM71.14536023
46MARK21.08084976
47RPS6KA41.03281856
48JAK21.00771205
49GRK61.00088009
50TRIB30.97935097
51PRKD20.95977221
52IRAK10.90022975
53PIM10.88173190
54STK40.87488152
55PKN20.85970900
56KDR0.85549620
57CAMK1G0.85121469
58RIPK10.82695783
59TAOK20.82468749
60MARK30.80988440
61PAK40.79428667
62IRAK20.78561234
63PTK60.78416954
64CDK190.77440966
65BMPR20.76625994
66LRRK20.75375432
67MATK0.75280055
68CHUK0.74123978
69MAP3K70.73969610
70GRK70.65810016
71PIM20.65696212
72CDC42BPA0.64367213
73EGFR0.64276104
74PTK2B0.64228731
75SMG10.63457662
76MAP3K20.62295199
77STK110.62271980
78FGFR30.62225293
79CDK60.60833025
80TESK20.60547669
81PRKCD0.60417197
82MAPK70.60395680
83MAP3K30.60249860
84MAP2K40.59803125
85ABL10.59614556
86PIK3CG0.57698076
87CDK120.57385425
88FYN0.55971013
89DYRK1B0.55741777
90RPS6KA60.52763299
91FGFR40.52740143
92SCYL20.52315597
93PDK10.52246379
94YES10.52232301
95EPHA30.51474330
96HIPK20.50278204
97STK380.50196037
98NEK20.49846501
99CAMKK20.48769846
100RPS6KC10.45655915
101RPS6KL10.45655915
102MAP3K110.45510322
103RET0.45307776
104MAP3K100.45178468
105PRKCQ0.44600994
106CAMKK10.43676488
107MAP2K60.43537226
108PRKCH0.43518377
109MAPKAPK20.42108641
110RAF10.41729221
111PBK0.41510233
112RPS6KA20.39516777
113SIK10.38855909
114NLK0.38628801
115KSR10.37837310
116EIF2AK20.37600202
117PDPK10.36509126
118FLT30.35538011
119CDK40.35155469
120DAPK20.34497585
121TNK20.34099951
122SGK20.33471584
123MAP3K80.33140662
124CDK90.31669598
125PRKG20.29167068
126IGF1R0.28640613
127PRKCZ0.28260387
128ERBB30.27237571
129MAPK110.26885191
130MOS0.26697326
131SGK30.26320835
132MAP3K60.25990531
133MAPK120.25156250
134MAP3K50.24906401

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.43949396
2Staphylococcus aureus infection_Homo sapiens_hsa051503.18183476
3Osteoclast differentiation_Homo sapiens_hsa043802.69802776
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.68004314
5Lysosome_Homo sapiens_hsa041422.64985457
6Other glycan degradation_Homo sapiens_hsa005112.63679808
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28623399
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.21772468
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17925601
10Tuberculosis_Homo sapiens_hsa051522.16287536
11B cell receptor signaling pathway_Homo sapiens_hsa046622.12656292
12Pertussis_Homo sapiens_hsa051332.04969647
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04044719
14Measles_Homo sapiens_hsa051622.01466331
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90645936
16Graft-versus-host disease_Homo sapiens_hsa053321.90615040
17Malaria_Homo sapiens_hsa051441.89901756
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89700546
19Legionellosis_Homo sapiens_hsa051341.89555628
20Antigen processing and presentation_Homo sapiens_hsa046121.85443557
21Phagosome_Homo sapiens_hsa041451.78745009
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72714644
23Hematopoietic cell lineage_Homo sapiens_hsa046401.70753666
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66508615
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65969908
26Primary immunodeficiency_Homo sapiens_hsa053401.64262630
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.53177644
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53105646
29Rheumatoid arthritis_Homo sapiens_hsa053231.52782974
30Shigellosis_Homo sapiens_hsa051311.52401492
31Salmonella infection_Homo sapiens_hsa051321.49165471
32Influenza A_Homo sapiens_hsa051641.47967355
33Chemokine signaling pathway_Homo sapiens_hsa040621.47639110
34Toxoplasmosis_Homo sapiens_hsa051451.47008271
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46743140
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.45703972
37Apoptosis_Homo sapiens_hsa042101.45284938
38Allograft rejection_Homo sapiens_hsa053301.41728185
39Asthma_Homo sapiens_hsa053101.40952223
40TNF signaling pathway_Homo sapiens_hsa046681.35291685
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.27932826
42Herpes simplex infection_Homo sapiens_hsa051681.23982688
43T cell receptor signaling pathway_Homo sapiens_hsa046601.23908108
44Caffeine metabolism_Homo sapiens_hsa002321.21260811
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17989060
46Viral myocarditis_Homo sapiens_hsa054161.16400393
47Hepatitis B_Homo sapiens_hsa051611.15674168
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09687834
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07387189
50Platelet activation_Homo sapiens_hsa046110.98327333
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96090524
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95137336
53Acute myeloid leukemia_Homo sapiens_hsa052210.94749921
54Pancreatic cancer_Homo sapiens_hsa052120.91359256
55Hepatitis C_Homo sapiens_hsa051600.90307827
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82690553
57Renal cell carcinoma_Homo sapiens_hsa052110.82149552
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82069233
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79612186
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77602436
61African trypanosomiasis_Homo sapiens_hsa051430.75447637
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.75188790
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.69610597
64Epstein-Barr virus infection_Homo sapiens_hsa051690.67785928
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66794427
66Choline metabolism in cancer_Homo sapiens_hsa052310.64172796
67Amoebiasis_Homo sapiens_hsa051460.63723517
68Endocytosis_Homo sapiens_hsa041440.62455205
69Endometrial cancer_Homo sapiens_hsa052130.62242801
70GnRH signaling pathway_Homo sapiens_hsa049120.60568143
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60490899
72Collecting duct acid secretion_Homo sapiens_hsa049660.60436840
73VEGF signaling pathway_Homo sapiens_hsa043700.58921778
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58228165
75Dorso-ventral axis formation_Homo sapiens_hsa043200.57829029
76Complement and coagulation cascades_Homo sapiens_hsa046100.56793054
77Type I diabetes mellitus_Homo sapiens_hsa049400.56739210
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55522912
79Regulation of autophagy_Homo sapiens_hsa041400.54950337
80Sphingolipid metabolism_Homo sapiens_hsa006000.53958873
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52222139
82Autoimmune thyroid disease_Homo sapiens_hsa053200.50603553
83Viral carcinogenesis_Homo sapiens_hsa052030.50402901
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.49231876
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49206929
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48659601
87Non-small cell lung cancer_Homo sapiens_hsa052230.48274182
88Rap1 signaling pathway_Homo sapiens_hsa040150.47675254
89MAPK signaling pathway_Homo sapiens_hsa040100.46246809
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44922172
91HTLV-I infection_Homo sapiens_hsa051660.43947780
92Notch signaling pathway_Homo sapiens_hsa043300.41959027
93HIF-1 signaling pathway_Homo sapiens_hsa040660.41156413
94DNA replication_Homo sapiens_hsa030300.40152194
95Small cell lung cancer_Homo sapiens_hsa052220.40038722
96Prolactin signaling pathway_Homo sapiens_hsa049170.39920866
97Renin-angiotensin system_Homo sapiens_hsa046140.37959875
98ErbB signaling pathway_Homo sapiens_hsa040120.36848040
99Type II diabetes mellitus_Homo sapiens_hsa049300.33742826
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33494145
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33341009
102Insulin resistance_Homo sapiens_hsa049310.32992930
103Pentose phosphate pathway_Homo sapiens_hsa000300.30380630
104p53 signaling pathway_Homo sapiens_hsa041150.30309910
105Colorectal cancer_Homo sapiens_hsa052100.30126811
106Inositol phosphate metabolism_Homo sapiens_hsa005620.26824282
107Proteoglycans in cancer_Homo sapiens_hsa052050.26388387
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24713570
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.23709571
110Base excision repair_Homo sapiens_hsa034100.22494822
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21458611
112ABC transporters_Homo sapiens_hsa020100.21445474
113mTOR signaling pathway_Homo sapiens_hsa041500.20157668
114FoxO signaling pathway_Homo sapiens_hsa040680.20098057
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.20006371

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