MYO3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of megakaryocyte differentiation (GO:0045654)7.42009536
2positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)7.07119308
3vitamin biosynthetic process (GO:0009110)5.61277034
4endocrine pancreas development (GO:0031018)4.85361891
5sphingosine metabolic process (GO:0006670)4.75312448
6cellular ketone body metabolic process (GO:0046950)4.57351053
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.52108509
8glandular epithelial cell differentiation (GO:0002067)4.48671005
9diol metabolic process (GO:0034311)4.40992031
10vitamin D metabolic process (GO:0042359)4.39420531
11inositol phosphate catabolic process (GO:0071545)4.35448381
12phosphorylated carbohydrate dephosphorylation (GO:0046838)4.31824120
13inositol phosphate dephosphorylation (GO:0046855)4.31824120
14detection of bacterium (GO:0016045)4.29789349
15sphingoid metabolic process (GO:0046519)4.26296648
16response to lipoprotein particle (GO:0055094)4.23727317
17cilium or flagellum-dependent cell motility (GO:0001539)4.20087073
18establishment of protein localization to Golgi (GO:0072600)4.19815738
19negative regulation of transcription by competitive promoter binding (GO:0010944)4.19786066
20negative regulation of epidermal cell differentiation (GO:0045605)4.17532108
21regulation of keratinocyte proliferation (GO:0010837)4.17409860
22proline biosynthetic process (GO:0006561)4.01481824
23ketone body metabolic process (GO:1902224)4.01389227
24somite rostral/caudal axis specification (GO:0032525)3.99172078
25negative regulation of homotypic cell-cell adhesion (GO:0034111)3.97510674
26protein targeting to Golgi (GO:0000042)3.96280348
27oocyte maturation (GO:0001556)3.93924292
28intestinal epithelial cell development (GO:0060576)3.90552657
29detection of light stimulus involved in visual perception (GO:0050908)3.82379811
30detection of light stimulus involved in sensory perception (GO:0050962)3.82379811
31detection of other organism (GO:0098543)3.79540040
32mitotic metaphase plate congression (GO:0007080)3.74307356
33female mating behavior (GO:0060180)3.66873772
34cornea development in camera-type eye (GO:0061303)3.65338833
35regulation of DNA damage checkpoint (GO:2000001)3.65224554
36cell wall macromolecule metabolic process (GO:0044036)3.63553165
37cell wall macromolecule catabolic process (GO:0016998)3.63553165
38retrograde transport, vesicle recycling within Golgi (GO:0000301)3.63408106
39behavioral response to ethanol (GO:0048149)3.60261282
40protein localization to Golgi apparatus (GO:0034067)3.58002449
41respiratory chain complex IV assembly (GO:0008535)3.57817310
42epithelial cell fate commitment (GO:0072148)3.56028279
43glycerophospholipid catabolic process (GO:0046475)3.53974521
44regulation of megakaryocyte differentiation (GO:0045652)3.53859675
45thrombin receptor signaling pathway (GO:0070493)3.50466269
46cAMP-mediated signaling (GO:0019933)3.48760827
47positive regulation of NIK/NF-kappaB signaling (GO:1901224)3.43185175
48proline transport (GO:0015824)3.40257247
49keratinocyte development (GO:0003334)3.39510808
50calcium ion import (GO:0070509)3.38273607
51regulation of establishment or maintenance of cell polarity (GO:0032878)3.33579960
52regulation of establishment of cell polarity (GO:2000114)3.33423897
53polyol catabolic process (GO:0046174)3.33408005
54response to pheromone (GO:0019236)3.32604775
55G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.24614861
56polyol biosynthetic process (GO:0046173)3.23325327
57left/right axis specification (GO:0070986)3.22614981
58signal peptide processing (GO:0006465)3.22449186
59somite development (GO:0061053)3.22368323
60cytochrome complex assembly (GO:0017004)3.21161356
61positive regulation of microtubule polymerization (GO:0031116)3.18356534
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16521818
63intraciliary transport (GO:0042073)3.16379644
64cyclic nucleotide catabolic process (GO:0009214)3.15743412
65peptide hormone processing (GO:0016486)3.15253042
66positive regulation of glycolytic process (GO:0045821)3.13617779
67water-soluble vitamin biosynthetic process (GO:0042364)3.13427823
68centriole assembly (GO:0098534)3.11435117
69nodal signaling pathway (GO:0038092)3.09083012
70metaphase plate congression (GO:0051310)3.08888128
71fucose catabolic process (GO:0019317)3.06044899
72L-fucose metabolic process (GO:0042354)3.06044899
73L-fucose catabolic process (GO:0042355)3.06044899
74histone H3-K36 demethylation (GO:0070544)3.04355207
75protein localization to cilium (GO:0061512)3.02913521
76alanine transport (GO:0032328)3.02149236
77protein kinase C signaling (GO:0070528)3.01651880
78cAMP catabolic process (GO:0006198)2.94909405
79response to hepatocyte growth factor (GO:0035728)2.94408908
80cellular response to hepatocyte growth factor stimulus (GO:0035729)2.94408908
81negative regulation of keratinocyte proliferation (GO:0010839)2.93021190
82columnar/cuboidal epithelial cell development (GO:0002066)2.92952172
83proline metabolic process (GO:0006560)2.91251195
84regulation of female receptivity (GO:0045924)2.89722316
85fusion of sperm to egg plasma membrane (GO:0007342)2.88603881
86histone H3-K9 demethylation (GO:0033169)2.87592811
87insulin secretion (GO:0030073)2.87187277
88signal transduction involved in regulation of gene expression (GO:0023019)2.86825785
89histone lysine demethylation (GO:0070076)2.84529414
90microtubule depolymerization (GO:0007019)2.84047764
91protein polyglutamylation (GO:0018095)2.83178205
92regulation of type B pancreatic cell apoptotic process (GO:2000674)2.82234718
93regulation of bile acid biosynthetic process (GO:0070857)2.81632791
94meiotic chromosome segregation (GO:0045132)2.81276824
95negative regulation of epidermis development (GO:0045683)2.81012363
96regulation of NIK/NF-kappaB signaling (GO:1901222)2.80803274
97positive regulation of meiosis (GO:0045836)2.80210870
98nitric oxide mediated signal transduction (GO:0007263)2.80064473
99regulation of hexokinase activity (GO:1903299)2.79453852
100regulation of glucokinase activity (GO:0033131)2.79453852
101multicellular organism reproduction (GO:0032504)2.79144826
102regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.78510912
103lactate metabolic process (GO:0006089)2.77995837
104negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.77807318
105regulation of keratinocyte differentiation (GO:0045616)2.77633508
106calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77046090
107regulation of cilium movement (GO:0003352)2.76708448
108type B pancreatic cell development (GO:0003323)2.75020385
109positive regulation of protein autophosphorylation (GO:0031954)2.73108312
110gland morphogenesis (GO:0022612)2.72689723
111negative regulation of hormone metabolic process (GO:0032351)2.72572424
112negative regulation of hormone biosynthetic process (GO:0032353)2.72572424
113cilium organization (GO:0044782)2.71929243
114positive regulation of insulin secretion (GO:0032024)2.71472391
115citrulline biosynthetic process (GO:0019240)2.71242575
116negative regulation of neurological system process (GO:0031645)2.71195572
117negative regulation of insulin secretion (GO:0046676)2.69945922
118dorsal/ventral axis specification (GO:0009950)2.69615267
119cilium assembly (GO:0042384)2.69220707
120peptide hormone secretion (GO:0030072)2.68680567
121negative regulation of catecholamine secretion (GO:0033604)2.68445186
122regulation of protein kinase A signaling (GO:0010738)2.68089755
123kinetochore assembly (GO:0051382)2.67826409
124intra-Golgi vesicle-mediated transport (GO:0006891)2.67390748
125heart trabecula formation (GO:0060347)2.66791002
126prenylation (GO:0097354)2.66602767
127protein prenylation (GO:0018342)2.66602767
128kidney morphogenesis (GO:0060993)2.66499341
129pancreas development (GO:0031016)2.66330581
130nephron tubule morphogenesis (GO:0072078)2.65867821
131nephron epithelium morphogenesis (GO:0072088)2.65867821
132response to redox state (GO:0051775)2.64809587
133dentate gyrus development (GO:0021542)2.63424500
134male meiosis I (GO:0007141)2.63420863
135axoneme assembly (GO:0035082)2.62157955
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61969521
137nonmotile primary cilium assembly (GO:0035058)2.61466650
138peptide secretion (GO:0002790)2.61126768
139regulation of insulin secretion (GO:0050796)2.60710027
140cilium morphogenesis (GO:0060271)2.60575407
141positive regulation of mast cell activation involved in immune response (GO:0033008)2.58354643
142positive regulation of mast cell degranulation (GO:0043306)2.58354643
143positive regulation of meiotic cell cycle (GO:0051446)2.56701274
144epithelial cilium movement (GO:0003351)2.56443265
145histone H4-K12 acetylation (GO:0043983)2.55191692
146regulation of corticosteroid hormone secretion (GO:2000846)2.55086927
147positive regulation of peptide hormone secretion (GO:0090277)2.54875914
148detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54613156
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54152543
150regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53736661
151negative regulation of glycoprotein biosynthetic process (GO:0010561)2.53494798
152histone demethylation (GO:0016577)2.53203294
153protein maturation by protein folding (GO:0022417)2.52420893
154female gonad development (GO:0008585)2.52082615
155glandular epithelial cell development (GO:0002068)2.51317487
156poly(A)+ mRNA export from nucleus (GO:0016973)2.50835125
157chemosensory behavior (GO:0007635)2.49461716
158DNA integration (GO:0015074)2.49158399
159photoreceptor cell maintenance (GO:0045494)2.48046367
160activation of NF-kappaB-inducing kinase activity (GO:0007250)2.47885607
161brain morphogenesis (GO:0048854)2.47868060
162centriole replication (GO:0007099)2.47867039
163protein localization to chromosome, centromeric region (GO:0071459)2.47865351
164magnesium ion transport (GO:0015693)2.46591848
165positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.44972181
166dendritic spine morphogenesis (GO:0060997)2.44043561
167positive regulation of peptide secretion (GO:0002793)2.42904439
168xenobiotic catabolic process (GO:0042178)2.41069775
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40467984
170regulation of neurotransmitter uptake (GO:0051580)2.39292886
171phenylpropanoid metabolic process (GO:0009698)2.39238717
172replication fork processing (GO:0031297)2.39186421
173phospholipid dephosphorylation (GO:0046839)2.36229355
174neuron fate determination (GO:0048664)2.35678277
175regulation of mesoderm development (GO:2000380)2.34912831
176negative regulation of activin receptor signaling pathway (GO:0032926)2.34755338
177regulation of peptide hormone secretion (GO:0090276)2.34647048
178auditory receptor cell differentiation (GO:0042491)2.34310491
179preassembly of GPI anchor in ER membrane (GO:0016254)2.33532203
180neuron fate specification (GO:0048665)2.31259988
181presynaptic membrane assembly (GO:0097105)2.30793849
182protein K11-linked deubiquitination (GO:0035871)2.27605634
183regulation of peptide secretion (GO:0002791)2.27452570
184cellular component assembly involved in morphogenesis (GO:0010927)2.26502727
185acrosome assembly (GO:0001675)2.26007698
186adult feeding behavior (GO:0008343)2.24173696
187fat-soluble vitamin biosynthetic process (GO:0042362)12.7687922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.28172004
2* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.71056325
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52892744
4EZH2_22144423_ChIP-Seq_EOC_Human3.24840563
5GBX2_23144817_ChIP-Seq_PC3_Human3.09560148
6ZNF274_21170338_ChIP-Seq_K562_Hela2.76456673
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55450905
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.54651210
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44474221
10* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12902099
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.09907638
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.08798896
13MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse2.08559401
14IGF1R_20145208_ChIP-Seq_DFB_Human2.04232457
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02197655
16SUZ12_27294783_Chip-Seq_NPCs_Mouse1.98415504
17* NANOG_18555785_Chip-Seq_ESCs_Mouse1.92287732
18EZH2_27294783_Chip-Seq_NPCs_Mouse1.92146330
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.91622392
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89605214
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87620865
22EWS_26573619_Chip-Seq_HEK293_Human1.83014377
23* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.82185900
24* P53_22387025_ChIP-Seq_ESCs_Mouse1.79929432
25VDR_22108803_ChIP-Seq_LS180_Human1.75628914
26* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75461227
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74394331
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.74115342
29CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.70321245
30* STAT3_18555785_Chip-Seq_ESCs_Mouse1.69878327
31* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.69738622
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68805571
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65625968
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63487674
35RNF2_27304074_Chip-Seq_NSC_Mouse1.62570884
36CRX_20693478_ChIP-Seq_RETINA_Mouse1.62157967
37ER_23166858_ChIP-Seq_MCF-7_Human1.59639695
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59117467
39* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.58517880
40* CMYC_18555785_Chip-Seq_ESCs_Mouse1.57858450
41* E2F1_18555785_Chip-Seq_ESCs_Mouse1.57658545
42SOX2_18555785_Chip-Seq_ESCs_Mouse1.57367312
43STAT3_23295773_ChIP-Seq_U87_Human1.56550920
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55734934
45AR_25329375_ChIP-Seq_VCAP_Human1.54807625
46* NMYC_18555785_Chip-Seq_ESCs_Mouse1.54543168
47* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54194399
48KLF4_18555785_Chip-Seq_ESCs_Mouse1.52742192
49OCT4_18555785_Chip-Seq_ESCs_Mouse1.52295396
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.50708893
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.50169928
52ESRRB_18555785_Chip-Seq_ESCs_Mouse1.47351745
53RUNX1_27457419_Chip-Seq_LIVER_Mouse1.46956021
54* P300_18555785_Chip-Seq_ESCs_Mouse1.45811442
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45507949
56SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.44649247
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43360872
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41311473
59CBP_20019798_ChIP-Seq_JUKART_Human1.40987542
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40987542
61GATA1_22025678_ChIP-Seq_K562_Human1.40734906
62* CTCF_18555785_Chip-Seq_ESCs_Mouse1.39549562
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.39323478
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.39148111
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.38911794
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38894636
67SMAD1_18555785_Chip-Seq_ESCs_Mouse1.37913850
68* KDM2B_26808549_Chip-Seq_REH_Human1.37299702
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37087706
70STAT1_17558387_ChIP-Seq_HELA_Human1.35952619
71FUS_26573619_Chip-Seq_HEK293_Human1.34565625
72* PU1_27457419_Chip-Seq_LIVER_Mouse1.33426836
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32607659
74TCF4_22108803_ChIP-Seq_LS180_Human1.31359230
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31138011
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.30870822
77TP53_22573176_ChIP-Seq_HFKS_Human1.30648189
78ZFX_18555785_Chip-Seq_ESCs_Mouse1.30243608
79HTT_18923047_ChIP-ChIP_STHdh_Human1.29419412
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29403651
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28935925
82BCAT_22108803_ChIP-Seq_LS180_Human1.28677066
83* TBL1_22424771_ChIP-Seq_293T_Human1.28264992
84* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27879610
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.27831299
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.27759180
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27318615
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26817701
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25010673
90* P300_19829295_ChIP-Seq_ESCs_Human1.23715654
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.22896936
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22783428
93REST_21632747_ChIP-Seq_MESCs_Mouse1.22661997
94* NFYA_21822215_ChIP-Seq_K562_Human1.22149290
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20769244
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.20139319
97* TCF4_23295773_ChIP-Seq_U87_Human1.19949461
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19899643
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19899643
100* NFYB_21822215_ChIP-Seq_K562_Human1.18256073
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15747956
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15227923
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13608968
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13378309
105* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13128769
106CDX2_22108803_ChIP-Seq_LS180_Human1.12860128
107TAF15_26573619_Chip-Seq_HEK293_Human1.11369727
108* SOX2_19829295_ChIP-Seq_ESCs_Human1.11262226
109* NANOG_19829295_ChIP-Seq_ESCs_Human1.11262226
110* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11034219
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10297097
112* SMAD3_21741376_ChIP-Seq_EPCs_Human1.09595138
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09286797
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.09141035
115RUNX2_22187159_ChIP-Seq_PCA_Human1.08564055
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08530429
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07799789
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.07606313
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07427178
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.06973274
121EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05589368
122RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05589368
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04343374
124* CBP_21632823_ChIP-Seq_H3396_Human1.04335907
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.04165240
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03933022
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03397518
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03245886
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03192619
130SMAD4_21741376_ChIP-Seq_HESCs_Human1.02640900
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02577781
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02158196
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01191331
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00863504
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00311719
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.00127141
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99787114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.26055553
2MP0003283_abnormal_digestive_organ4.87033176
3MP0000462_abnormal_digestive_system3.89463834
4MP0005379_endocrine/exocrine_gland_phen3.66496645
5MP0002877_abnormal_melanocyte_morpholog3.44010783
6MP0003879_abnormal_hair_cell3.34902317
7MP0006292_abnormal_olfactory_placode3.34489535
8MP0002837_dystrophic_cardiac_calcinosis3.33774294
9MP0004381_abnormal_hair_follicle3.06095185
10MP0003122_maternal_imprinting2.84766537
11MP0004043_abnormal_pH_regulation2.82400485
12MP0002693_abnormal_pancreas_physiology2.75594134
13MP0001188_hyperpigmentation2.55047264
14MP0001944_abnormal_pancreas_morphology2.52548408
15MP0006072_abnormal_retinal_apoptosis2.25664796
16MP0003183_abnormal_peptide_metabolism2.12360869
17MP0002163_abnormal_gland_morphology2.05254195
18MP0009046_muscle_twitch2.02720660
19MP0001485_abnormal_pinna_reflex2.02202318
20MP0005646_abnormal_pituitary_gland2.01952755
21MP0000613_abnormal_salivary_gland2.01736520
22MP0003121_genomic_imprinting1.99452291
23MP0005257_abnormal_intraocular_pressure1.89466884
24MP0009780_abnormal_chondrocyte_physiolo1.85494495
25MP0002938_white_spotting1.85352339
26MP0004133_heterotaxia1.82488993
27MP0001984_abnormal_olfaction1.81853488
28MP0009840_abnormal_foam_cell1.76796866
29MP0005670_abnormal_white_adipose1.75724714
30MP0010234_abnormal_vibrissa_follicle1.74374962
31MP0005377_hearing/vestibular/ear_phenot1.69700353
32MP0003878_abnormal_ear_physiology1.69700353
33MP0000647_abnormal_sebaceous_gland1.69106931
34MP0004147_increased_porphyrin_level1.62490656
35MP0001986_abnormal_taste_sensitivity1.62089923
36MP0010386_abnormal_urinary_bladder1.61752506
37MP0005220_abnormal_exocrine_pancreas1.60396709
38MP0008877_abnormal_DNA_methylation1.53704146
39MP0000427_abnormal_hair_cycle1.53080264
40MP0000579_abnormal_nail_morphology1.49807991
41MP0005451_abnormal_body_composition1.47004804
42MP0003693_abnormal_embryo_hatching1.45170266
43MP0000569_abnormal_digit_pigmentation1.41891449
44MP0005367_renal/urinary_system_phenotyp1.38683872
45MP0000516_abnormal_urinary_system1.38683872
46MP0002557_abnormal_social/conspecific_i1.34567252
47MP0003119_abnormal_digestive_system1.32932166
48MP0005410_abnormal_fertilization1.29499113
49MP0000678_abnormal_parathyroid_gland1.28383387
50MP0005332_abnormal_amino_acid1.28087300
51MP0005253_abnormal_eye_physiology1.25093523
52MP0009745_abnormal_behavioral_response1.24830184
53MP0003787_abnormal_imprinting1.24538239
54MP0005310_abnormal_salivary_gland1.24528506
55MP0004264_abnormal_extraembryonic_tissu1.24267797
56MP0002060_abnormal_skin_morphology1.23125830
57MP0003195_calcinosis1.22276305
58MP0001765_abnormal_ion_homeostasis1.22125041
59MP0002254_reproductive_system_inflammat1.21399199
60MP0002078_abnormal_glucose_homeostasis1.21192400
61MP0003880_abnormal_central_pattern1.19572441
62MP0005645_abnormal_hypothalamus_physiol1.18605785
63MP0001486_abnormal_startle_reflex1.15480079
64MP0002277_abnormal_respiratory_mucosa1.15458988
65MP0002090_abnormal_vision1.14968339
66MP0003011_delayed_dark_adaptation1.14872026
67MP0002272_abnormal_nervous_system1.14392141
68MP0002876_abnormal_thyroid_physiology1.13762693
69MP0001346_abnormal_lacrimal_gland1.13386397
70MP0002009_preneoplasia1.12951865
71MP0004742_abnormal_vestibular_system1.12821825
72MP0010329_abnormal_lipoprotein_level1.11316807
73MP0010678_abnormal_skin_adnexa1.10971914
74MP0002184_abnormal_innervation1.10611138
75MP0002177_abnormal_outer_ear1.09730943
76MP0003890_abnormal_embryonic-extraembry1.09189163
77MP0002572_abnormal_emotion/affect_behav1.08847605
78MP0002796_impaired_skin_barrier1.08803433
79MP0003123_paternal_imprinting1.06370931
80MP0008057_abnormal_DNA_replication1.05570117
81MP0002064_seizures1.04674478
82MP0008872_abnormal_physiological_respon1.04245240
83MP0003718_maternal_effect1.04244022
84MP0005174_abnormal_tail_pigmentation1.02671777
85MP0004142_abnormal_muscle_tone1.01781608
86MP0003300_gastrointestinal_ulcer1.01084096
87* MP0000026_abnormal_inner_ear0.96532006
88* MP0001963_abnormal_hearing_physiology0.95853053
89MP0002638_abnormal_pupillary_reflex0.95835678
90MP0001661_extended_life_span0.94969570
91MP0004885_abnormal_endolymph0.94859533
92MP0003252_abnormal_bile_duct0.94128144
93MP0001929_abnormal_gametogenesis0.92746421
94MP0001501_abnormal_sleep_pattern0.92396058
95MP0003937_abnormal_limbs/digits/tail_de0.91628542
96MP0004019_abnormal_vitamin_homeostasis0.91177444
97MP0003866_abnormal_defecation0.90931249
98MP0002928_abnormal_bile_duct0.90523438
99MP0005448_abnormal_energy_balance0.89319306
100MP0001727_abnormal_embryo_implantation0.89277524
101MP0004215_abnormal_myocardial_fiber0.89264347
102MP0001756_abnormal_urination0.88634825
103MP0002896_abnormal_bone_mineralization0.88014685
104MP0005084_abnormal_gallbladder_morpholo0.87619089
105MP0005365_abnormal_bile_salt0.86465783
106MP0001529_abnormal_vocalization0.86250802
107MP0005386_behavior/neurological_phenoty0.86219454
108MP0004924_abnormal_behavior0.86219454
109MP0002734_abnormal_mechanical_nocicepti0.85361960
110MP0005075_abnormal_melanosome_morpholog0.83556954
111MP0003953_abnormal_hormone_level0.82055343
112MP0002822_catalepsy0.81797397
113MP0005381_digestive/alimentary_phenotyp0.80325060
114MP0003938_abnormal_ear_development0.76725876
115MP0005391_vision/eye_phenotype0.76284919
116MP0008995_early_reproductive_senescence0.75982470
117MP0000013_abnormal_adipose_tissue0.75957966
118MP0000627_abnormal_mammary_gland0.75364560
119MP0001968_abnormal_touch/_nociception0.75028435
120MP0000383_abnormal_hair_follicle0.74591802
121MP0002909_abnormal_adrenal_gland0.74472310
122MP0003633_abnormal_nervous_system0.74032438
123MP0006036_abnormal_mitochondrial_physio0.72666932
124MP0005499_abnormal_olfactory_system0.72629142
125MP0005394_taste/olfaction_phenotype0.72629142
126MP0000631_abnormal_neuroendocrine_gland0.72514680
127MP0003786_premature_aging0.71807206
128MP0006276_abnormal_autonomic_nervous0.71694678
129MP0005195_abnormal_posterior_eye0.71666591
130MP0000639_abnormal_adrenal_gland0.69668196
131MP0008058_abnormal_DNA_repair0.69599138
132MP0008775_abnormal_heart_ventricle0.69239348
133MP0001905_abnormal_dopamine_level0.68393283
134MP0002160_abnormal_reproductive_system0.68214690
135MP0000653_abnormal_sex_gland0.67818318
136MP0005636_abnormal_mineral_homeostasis0.67304902
137MP0003698_abnormal_male_reproductive0.66130644
138MP0004185_abnormal_adipocyte_glucose0.65519710
139MP0002751_abnormal_autonomic_nervous0.65431598
140MP0001270_distended_abdomen0.64343000
141MP0000015_abnormal_ear_pigmentation0.63211892
142MP0004270_analgesia0.62870363
143MP0002210_abnormal_sex_determination0.62380931
144MP0004085_abnormal_heartbeat0.62081627
145MP0001243_abnormal_dermal_layer0.59430790
146MP0002233_abnormal_nose_morphology0.59085672
147MP0002735_abnormal_chemical_nociception0.56414096
148MP0005551_abnormal_eye_electrophysiolog0.55924104
149MP0000762_abnormal_tongue_morphology0.55109440
150MP0001186_pigmentation_phenotype0.54755417
151MP0000377_abnormal_hair_follicle0.54303673
152MP0001119_abnormal_female_reproductive0.54241306
153MP0003935_abnormal_craniofacial_develop0.53835328
154MP0002138_abnormal_hepatobiliary_system0.52696492

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)6.81571006
2Widely patent fontanelles and sutures (HP:0004492)6.54349344
3Hyperinsulinemic hypoglycemia (HP:0000825)6.19865510
4Enlarged epiphyses (HP:0010580)6.12304860
5Delayed epiphyseal ossification (HP:0002663)6.02823739
6Wide cranial sutures (HP:0010537)4.80048454
7Hypoglycemic seizures (HP:0002173)4.74686603
8Symptomatic seizures (HP:0011145)4.55715600
9Congenital stationary night blindness (HP:0007642)4.46876749
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43864389
11Abnormality of the costochondral junction (HP:0000919)4.41768504
12Papilledema (HP:0001085)4.03069263
13Severe visual impairment (HP:0001141)4.02964032
14Intestinal atresia (HP:0011100)3.84852077
15Metaphyseal irregularity (HP:0003025)3.71539158
16Hyperglycemia (HP:0003074)3.71350496
17Hypoglycemic coma (HP:0001325)3.65643020
18Chromsome breakage (HP:0040012)3.60927666
19Flat occiput (HP:0005469)3.59667704
20Tibial bowing (HP:0002982)3.59126646
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.54001300
22Abnormal rod and cone electroretinograms (HP:0008323)3.52456269
23Abnormality of the fovea (HP:0000493)3.46190410
24Central scotoma (HP:0000603)3.42664375
25Insulin-resistant diabetes mellitus (HP:0000831)3.42103118
26Abnormality of macular pigmentation (HP:0008002)3.25090065
27Spontaneous abortion (HP:0005268)3.23253381
28Upper limb muscle weakness (HP:0003484)3.19928283
29Albinism (HP:0001022)3.10376516
30Pancreatic fibrosis (HP:0100732)3.09553954
31Osteomalacia (HP:0002749)3.09316188
32Abnormality of midbrain morphology (HP:0002418)3.07632863
33Molar tooth sign on MRI (HP:0002419)3.07632863
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.04937486
35Decreased circulating renin level (HP:0003351)2.95657938
36Abnormality of the renal cortex (HP:0011035)2.80232449
37Double outlet right ventricle (HP:0001719)2.79222522
38Congenital malformation of the right heart (HP:0011723)2.79222522
39Nephronophthisis (HP:0000090)2.78119456
40Hypophosphatemia (HP:0002148)2.71622303
41Duplicated collecting system (HP:0000081)2.71437892
42Pancreatic cysts (HP:0001737)2.65576464
43Abnormality of endocrine pancreas physiology (HP:0012093)2.65335510
44Abnormality of the pancreatic islet cells (HP:0006476)2.65335510
45Rickets (HP:0002748)2.61797331
46Medial flaring of the eyebrow (HP:0010747)2.61222730
47Ectopic kidney (HP:0000086)2.61005765
48Aplasia/Hypoplasia of the macula (HP:0008059)2.58697597
49Proximal tubulopathy (HP:0000114)2.56652785
50Ventricular fibrillation (HP:0001663)2.53512147
51Elevated alkaline phosphatase (HP:0003155)2.51553836
52Tubulointerstitial nephritis (HP:0001970)2.50246042
53Abnormal pancreas size (HP:0012094)2.48846040
54Lip pit (HP:0100267)2.48117416
55Renal cortical cysts (HP:0000803)2.42003424
56Hypomagnesemia (HP:0002917)2.41511131
57Scotoma (HP:0000575)2.40758831
58Ketosis (HP:0001946)2.40677909
59Femoral bowing (HP:0002980)2.39021224
60Chronic hepatic failure (HP:0100626)2.38892479
61Abnormality of the renal collecting system (HP:0004742)2.38124872
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.38020909
63True hermaphroditism (HP:0010459)2.37655362
64Abnormality of the renal medulla (HP:0100957)2.36182260
65Increased circulating renin level (HP:0000848)2.34806444
66Hemiparesis (HP:0001269)2.34720471
67Reduced antithrombin III activity (HP:0001976)2.34617558
68Submucous cleft hard palate (HP:0000176)2.34208281
69Aqueductal stenosis (HP:0002410)2.34046298
70Absent/shortened dynein arms (HP:0200106)2.33471121
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.33471121
72Tubular atrophy (HP:0000092)2.32786693
73Optic nerve hypoplasia (HP:0000609)2.31572409
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.29834254
75Abnormality of alkaline phosphatase activity (HP:0004379)2.26970067
76Methylmalonic acidemia (HP:0002912)2.25003770
77Focal motor seizures (HP:0011153)2.24735446
78Abnormality of the metopic suture (HP:0005556)2.23893953
79Polydipsia (HP:0001959)2.22356531
80Abnormal drinking behavior (HP:0030082)2.22356531
81Abnormality of vitamin B metabolism (HP:0004340)2.21848300
82Hypothermia (HP:0002045)2.20853088
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.19482520
84EEG with generalized epileptiform discharges (HP:0011198)2.17981192
85Microretrognathia (HP:0000308)2.17491582
86Abnormal enzyme/coenzyme activity (HP:0012379)2.15480935
87Epileptiform EEG discharges (HP:0011182)2.15177188
88Hypsarrhythmia (HP:0002521)2.15085137
89Congenital primary aphakia (HP:0007707)2.11769261
90Congenital sensorineural hearing impairment (HP:0008527)2.10833145
91Abnormality of the preputium (HP:0100587)2.09971001
92Abnormality of the duodenum (HP:0002246)2.09963257
93Hypokalemia (HP:0002900)2.09168552
94Abnormal respiratory motile cilium physiology (HP:0012261)2.08297738
95Disproportionate short-trunk short stature (HP:0003521)2.07884002
96Prominent metopic ridge (HP:0005487)2.07630731
97Abnormal ciliary motility (HP:0012262)2.06657678
98Genital tract atresia (HP:0001827)2.06580123
99Neoplasm of the adrenal cortex (HP:0100641)2.06098820
100Gait imbalance (HP:0002141)2.06068266
101Hepatic necrosis (HP:0002605)2.05142382
102Abnormal cortical bone morphology (HP:0003103)2.04738647
103Glycosuria (HP:0003076)2.04078424
104Abnormality of urine glucose concentration (HP:0011016)2.04078424
105Abnormality of renin-angiotensin system (HP:0000847)2.03715233
106Cystic liver disease (HP:0006706)2.03344699
107Enlarged penis (HP:0000040)2.03342224
108Median cleft lip (HP:0000161)2.02777476
109Abnormal respiratory motile cilium morphology (HP:0005938)2.02489822
110Abnormal respiratory epithelium morphology (HP:0012253)2.02489822
111Abnormality of the fibula (HP:0002991)1.98850255
112Abnormality of the labia minora (HP:0012880)1.98844864
113Attenuation of retinal blood vessels (HP:0007843)1.97576481
114Agitation (HP:0000713)1.97240892
115Volvulus (HP:0002580)1.97050125
116Septo-optic dysplasia (HP:0100842)1.95401451
117Abnormal trabecular bone morphology (HP:0100671)1.95182982
118Hyperventilation (HP:0002883)1.94579045
119Gastrointestinal atresia (HP:0002589)1.94518663
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94358651
121Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93810852
122Aplasia cutis congenita (HP:0001057)1.90769714
123Gaze-evoked nystagmus (HP:0000640)1.88336784
124Abnormality of polysaccharide metabolism (HP:0011012)1.88162865
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88162865
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88162865
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.86245970
128Large for gestational age (HP:0001520)1.85837685
129Chronic bronchitis (HP:0004469)1.84994570
130Nephrogenic diabetes insipidus (HP:0009806)1.84199368
131Abnormality of vitamin metabolism (HP:0100508)1.84046049
132Short tibia (HP:0005736)1.81553362
133Urinary glycosaminoglycan excretion (HP:0003541)1.81320172
134Mucopolysacchariduria (HP:0008155)1.81320172
135Unilateral renal agenesis (HP:0000122)1.80102665
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79697869
137Metabolic alkalosis (HP:0200114)1.79418656
138Generalized aminoaciduria (HP:0002909)1.79225206
139Oligodactyly (hands) (HP:0001180)1.78525474
140Prostate neoplasm (HP:0100787)1.78134036
141Popliteal pterygium (HP:0009756)1.76795228
142Abnormality of abdominal situs (HP:0011620)1.76544285
143Abdominal situs inversus (HP:0003363)1.76544285
144Thickened helices (HP:0000391)1.75838287
145Vaginal atresia (HP:0000148)1.75722420
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.75576625
147Aplasia/Hypoplasia of the fovea (HP:0008060)1.75455164
148Hypoplasia of the fovea (HP:0007750)1.75455164
149Hyperactive renin-angiotensin system (HP:0000841)1.74428622
150Labial hypoplasia (HP:0000066)1.74397417
151Thrombocytosis (HP:0001894)1.73415877
152Chin dimple (HP:0010751)1.73064425
153Abnormality of the gastric mucosa (HP:0004295)1.72852052
154Bone pain (HP:0002653)1.72291937
155Abnormality of the intrinsic pathway (HP:0010989)1.71781429
156Furrowed tongue (HP:0000221)1.71760396
157Fetal akinesia sequence (HP:0001989)1.71611534
158Late onset (HP:0003584)1.71512598
159Rhinitis (HP:0012384)1.70920546
160Type I transferrin isoform profile (HP:0003642)1.70876458
161Methylmalonic aciduria (HP:0012120)1.70871619
162Renal agenesis (HP:0000104)1.70703283
163Anteriorly placed anus (HP:0001545)1.70139550
164Downturned corners of mouth (HP:0002714)1.70125028
165Progressive macrocephaly (HP:0004481)1.69275978
166Absent eyebrow (HP:0002223)1.69110327
167Hematochezia (HP:0002573)1.68732859
168Abnormality of the right ventricle (HP:0001707)1.67931314
169Short thumb (HP:0009778)1.67887170
170Abnormality of magnesium homeostasis (HP:0004921)1.67154422
171Congenital hepatic fibrosis (HP:0002612)1.65647386
172Preaxial hand polydactyly (HP:0001177)1.65538953
173Febrile seizures (HP:0002373)1.65394214
174Insulin resistance (HP:0000855)1.65342465
175Aplasia/hypoplasia of the uterus (HP:0008684)1.64503669
176Ectopic anus (HP:0004397)1.63871548
177Polyuria (HP:0000103)1.63764230
178Generalized hypopigmentation (HP:0007513)1.62996985
179Ketoacidosis (HP:0001993)1.62184586
180Bradycardia (HP:0001662)1.61074764
181Pancreatic islet-cell hyperplasia (HP:0004510)1.58702581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.13151913
2LATS13.78957334
3ACVR1B3.64634350
4MAP3K93.45637521
5MAP4K23.41485635
6INSRR3.00123394
7BMPR1B2.93895048
8TAOK32.81613162
9STK242.78170416
10ARAF2.77271853
11PASK2.77043119
12MAP3K132.70711456
13STK162.68300856
14FGFR22.62314044
15BRSK22.48989955
16STK38L2.47519493
17BRAF2.38418400
18EIF2AK22.12545372
19PNCK2.10077519
20STK32.02215220
21MAPK151.98898029
22TIE11.98044806
23PTK61.92200510
24CDK31.90336502
25BRD41.80028400
26MST41.78322147
27AKT31.71825875
28FRK1.67389588
29DAPK21.66157513
30LATS21.59702719
31FLT31.52738193
32BLK1.51630650
33PTK21.51261699
34PLK21.45534995
35PHKG21.44999313
36PHKG11.44999313
37MAP3K41.40608853
38HIPK21.40527638
39CSNK1G11.39573019
40TLK11.39237844
41IRAK31.32759666
42PINK11.32116207
43GRK11.26480700
44ZAK1.23913323
45PIK3CG1.20896586
46WNK41.18607871
47CAMK1D1.17262553
48CSNK1G21.15992916
49TRPM71.15196849
50MST1R1.15194283
51CSNK1G31.13601113
52PLK41.12757502
53TEC1.09884052
54CDC42BPA1.09688669
55BRSK11.05776283
56ERBB41.03915317
57CDK121.00742836
58EIF2AK30.99398769
59NLK0.97525358
60PTK2B0.96070686
61ERBB30.95529881
62TRIM280.94248333
63CSNK1A1L0.93117720
64PLK30.93068379
65PKN10.92546938
66MAP2K70.92203699
67SCYL20.87237786
68TNIK0.86899931
69PRKCG0.85366444
70PRKAA10.84172662
71NME10.83849328
72SGK20.81942220
73MARK20.80325900
74ADRBK10.79722538
75NUAK10.78869596
76MOS0.78204570
77CASK0.76599369
78PRKD30.75038585
79FER0.74023066
80CAMK1G0.73734193
81KSR20.70200882
82MKNK20.70021003
83PRKAA20.69798901
84BMPR20.67280689
85TGFBR10.66733525
86MET0.66532528
87NTRK30.64169551
88PRKCH0.62715978
89CAMK10.61922336
90EPHA40.60523869
91JAK20.60476957
92NTRK10.58132109
93SGK10.57998524
94STK110.56685508
95WNK30.56003664
96FGFR30.55405175
97ATM0.55286591
98PAK30.55254848
99PRKCE0.54450731
100MAP3K60.53586988
101PRKG10.53303270
102CDK90.53093920
103CHEK20.52849461
104YES10.52182298
105BCR0.51435755
106CSNK1A10.50083956
107SGK30.49336668
108MAPK100.48986679
109ITK0.48227712
110ATR0.48025961
111WEE10.46331773
112SGK4940.45800485
113SGK2230.45800485
114TTK0.45364720
115RIPK40.44628618
116CAMK2A0.43117992
117PLK10.42678495
118MAP3K20.42565313
119ROCK10.40392643
120PDGFRA0.39574437
121STK390.38461939
122PRKACA0.38289682
123VRK10.38154769
124PRKACG0.37626156
125OXSR10.37515409
126CSNK1E0.37469013
127DYRK20.37223912
128NEK20.36175664
129AURKB0.35521223
130DAPK10.35101598
131PRKCZ0.34662428
132PRKACB0.34555395
133MAPK130.34288828
134CAMK2D0.34263294
135MAP2K60.34191034
136ADRBK20.34159230
137RAF10.33878435
138UHMK10.33815665
139MAPK140.33376931
140CHEK10.32790052
141MARK10.32743679
142AKT10.32432694
143MKNK10.31210722
144IRAK40.30887263
145CSNK1D0.29965900
146MAPK70.29813937
147PRKD20.29038777
148PRKDC0.25236356
149FGFR10.25032140
150PRKCI0.24400211
151MELK0.24131561
152CDK50.21915249

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.87267659
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.16751707
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.30044863
4Steroid biosynthesis_Homo sapiens_hsa001002.74577943
5Insulin secretion_Homo sapiens_hsa049112.73853401
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.64896537
7Sulfur metabolism_Homo sapiens_hsa009202.10748109
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.05381308
9Taste transduction_Homo sapiens_hsa047421.79179912
10Type II diabetes mellitus_Homo sapiens_hsa049301.77778092
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69003275
12Vitamin B6 metabolism_Homo sapiens_hsa007501.57116467
13Propanoate metabolism_Homo sapiens_hsa006401.55582273
14Butanoate metabolism_Homo sapiens_hsa006501.51668235
15Regulation of autophagy_Homo sapiens_hsa041401.50867569
16Prolactin signaling pathway_Homo sapiens_hsa049171.42841046
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42412660
18Protein export_Homo sapiens_hsa030601.38570019
19Other glycan degradation_Homo sapiens_hsa005111.37130629
20Sphingolipid metabolism_Homo sapiens_hsa006001.36481623
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35293403
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34198078
23Tryptophan metabolism_Homo sapiens_hsa003801.33783742
24Oxidative phosphorylation_Homo sapiens_hsa001901.32349235
25Cocaine addiction_Homo sapiens_hsa050301.29910131
26Basal transcription factors_Homo sapiens_hsa030221.27550745
27Fatty acid metabolism_Homo sapiens_hsa012121.26045154
28Type I diabetes mellitus_Homo sapiens_hsa049401.25595824
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.24647679
30Fanconi anemia pathway_Homo sapiens_hsa034601.21727536
31Lysine degradation_Homo sapiens_hsa003101.19016703
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12605707
33Collecting duct acid secretion_Homo sapiens_hsa049661.06859569
34Homologous recombination_Homo sapiens_hsa034401.06649675
35Non-homologous end-joining_Homo sapiens_hsa034501.05850303
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05614590
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05346174
38Peroxisome_Homo sapiens_hsa041461.04083016
39Amphetamine addiction_Homo sapiens_hsa050311.02326673
40Ovarian steroidogenesis_Homo sapiens_hsa049131.01044494
41Fatty acid degradation_Homo sapiens_hsa000710.99126489
42Renin secretion_Homo sapiens_hsa049240.97672976
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97542023
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97333943
45Linoleic acid metabolism_Homo sapiens_hsa005910.94642982
46Histidine metabolism_Homo sapiens_hsa003400.94556185
47Nicotine addiction_Homo sapiens_hsa050330.94434910
48Dorso-ventral axis formation_Homo sapiens_hsa043200.93582791
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90301895
50Morphine addiction_Homo sapiens_hsa050320.86015079
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85235768
52Arachidonic acid metabolism_Homo sapiens_hsa005900.85047225
53Circadian rhythm_Homo sapiens_hsa047100.84185154
54One carbon pool by folate_Homo sapiens_hsa006700.84156195
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.83761823
56p53 signaling pathway_Homo sapiens_hsa041150.83688764
57ABC transporters_Homo sapiens_hsa020100.81715470
58RNA degradation_Homo sapiens_hsa030180.81658619
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80749589
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80582865
61Hedgehog signaling pathway_Homo sapiens_hsa043400.80137915
62beta-Alanine metabolism_Homo sapiens_hsa004100.78861423
63Nitrogen metabolism_Homo sapiens_hsa009100.78552349
64Choline metabolism in cancer_Homo sapiens_hsa052310.78149887
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76815553
66Glucagon signaling pathway_Homo sapiens_hsa049220.75598444
67Selenocompound metabolism_Homo sapiens_hsa004500.75026286
68TGF-beta signaling pathway_Homo sapiens_hsa043500.74373491
69Arginine and proline metabolism_Homo sapiens_hsa003300.73768104
70Serotonergic synapse_Homo sapiens_hsa047260.73694688
71Mineral absorption_Homo sapiens_hsa049780.73511529
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72854101
73Cardiac muscle contraction_Homo sapiens_hsa042600.69820648
74Glutathione metabolism_Homo sapiens_hsa004800.69310017
75GnRH signaling pathway_Homo sapiens_hsa049120.68877730
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68875743
77Estrogen signaling pathway_Homo sapiens_hsa049150.68475512
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.68194571
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68101312
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67245637
81Ether lipid metabolism_Homo sapiens_hsa005650.66184939
82Metabolic pathways_Homo sapiens_hsa011000.63423480
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62504526
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62199667
85Pancreatic secretion_Homo sapiens_hsa049720.61762790
86Parkinsons disease_Homo sapiens_hsa050120.61509881
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60816026
88Alzheimers disease_Homo sapiens_hsa050100.58865127
89ErbB signaling pathway_Homo sapiens_hsa040120.58543482
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57823264
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57589998
92cAMP signaling pathway_Homo sapiens_hsa040240.57330930
93Cell cycle_Homo sapiens_hsa041100.56515743
94Caffeine metabolism_Homo sapiens_hsa002320.56376021
95Thyroid hormone synthesis_Homo sapiens_hsa049180.56052403
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.54028672
97Synaptic vesicle cycle_Homo sapiens_hsa047210.53488609
98Fat digestion and absorption_Homo sapiens_hsa049750.52472017
99Calcium signaling pathway_Homo sapiens_hsa040200.52410242
100Hematopoietic cell lineage_Homo sapiens_hsa046400.52203184
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51998050
102Vitamin digestion and absorption_Homo sapiens_hsa049770.51404238
103Cholinergic synapse_Homo sapiens_hsa047250.51351446
104Dopaminergic synapse_Homo sapiens_hsa047280.49272369
105Phototransduction_Homo sapiens_hsa047440.48919289
106Melanoma_Homo sapiens_hsa052180.47911570
107Prostate cancer_Homo sapiens_hsa052150.47457663
108Folate biosynthesis_Homo sapiens_hsa007900.46440575
109Salivary secretion_Homo sapiens_hsa049700.46027586
110Chemical carcinogenesis_Homo sapiens_hsa052040.45817147
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45810017
112N-Glycan biosynthesis_Homo sapiens_hsa005100.45586718
113Bladder cancer_Homo sapiens_hsa052190.44866943
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.44313917
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44309119
116Fatty acid biosynthesis_Homo sapiens_hsa000610.43829943
117Melanogenesis_Homo sapiens_hsa049160.43324650
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42885424
119Starch and sucrose metabolism_Homo sapiens_hsa005000.42822386
120RNA polymerase_Homo sapiens_hsa030200.42404243
121GABAergic synapse_Homo sapiens_hsa047270.42074103
122Ras signaling pathway_Homo sapiens_hsa040140.41808301
123Olfactory transduction_Homo sapiens_hsa047400.41170986
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40969472
125Tight junction_Homo sapiens_hsa045300.40650820
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40532752
127FoxO signaling pathway_Homo sapiens_hsa040680.39832440
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39804877
129MicroRNAs in cancer_Homo sapiens_hsa052060.39779036
130Retinol metabolism_Homo sapiens_hsa008300.39698673
131Basal cell carcinoma_Homo sapiens_hsa052170.37748820
132Pancreatic cancer_Homo sapiens_hsa052120.35971322
133Hepatitis C_Homo sapiens_hsa051600.32754547
134Purine metabolism_Homo sapiens_hsa002300.31771565
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.31571846
136AMPK signaling pathway_Homo sapiens_hsa041520.31462933
137Fatty acid elongation_Homo sapiens_hsa000620.31237333
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.31011287
139Circadian entrainment_Homo sapiens_hsa047130.30391581
140Alcoholism_Homo sapiens_hsa050340.30234543
141Glutamatergic synapse_Homo sapiens_hsa047240.29728236
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29293645
143MAPK signaling pathway_Homo sapiens_hsa040100.29253352
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28923773
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28194543
146Insulin resistance_Homo sapiens_hsa049310.27682938
147Phenylalanine metabolism_Homo sapiens_hsa003600.27384009

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »