MYO3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)8.64426372
2regulation of dendritic cell antigen processing and presentation (GO:0002604)7.73723152
3positive regulation of antigen processing and presentation (GO:0002579)7.17213447
4imidazole-containing compound metabolic process (GO:0052803)6.53785640
5oxygen transport (GO:0015671)6.37163532
6behavioral response to nicotine (GO:0035095)6.23021855
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.22311182
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.22311182
9regulation of antigen processing and presentation (GO:0002577)5.99378699
10neurotransmitter catabolic process (GO:0042135)5.80227343
11regulation of T-helper 1 cell differentiation (GO:0045625)5.26247577
12substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.12571501
13substrate-independent telencephalic tangential migration (GO:0021826)5.12571501
14positive regulation of granulocyte chemotaxis (GO:0071624)4.96547843
15NIK/NF-kappaB signaling (GO:0038061)4.90827177
16sulfation (GO:0051923)4.83781437
17antigen processing and presentation via MHC class Ib (GO:0002475)4.76868863
18positive regulation of T-helper 1 type immune response (GO:0002827)4.46383691
19water-soluble vitamin biosynthetic process (GO:0042364)4.37227630
20negative regulation of interleukin-10 production (GO:0032693)4.26224167
21kynurenine metabolic process (GO:0070189)4.24543612
22positive regulation of T-helper cell differentiation (GO:0045624)4.20654658
23indole-containing compound catabolic process (GO:0042436)4.17059913
24indolalkylamine catabolic process (GO:0046218)4.17059913
25tryptophan catabolic process (GO:0006569)4.17059913
26negative thymic T cell selection (GO:0045060)4.12511348
27DNA deamination (GO:0045006)4.04017909
28regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.03350039
29asymmetric protein localization (GO:0008105)4.00874137
30indolalkylamine metabolic process (GO:0006586)3.96232006
31negative T cell selection (GO:0043383)3.93999697
32cell proliferation in forebrain (GO:0021846)3.76967939
33regulation of Cdc42 GTPase activity (GO:0043088)3.70911910
34protein polyglutamylation (GO:0018095)3.68703142
35myelin maintenance (GO:0043217)3.62635379
36myeloid dendritic cell differentiation (GO:0043011)3.61258578
37cellular response to ATP (GO:0071318)3.58461497
38positive regulation of neutrophil migration (GO:1902624)3.57984674
39positive regulation of neutrophil chemotaxis (GO:0090023)3.57984674
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55296466
41gas transport (GO:0015669)3.50860513
42tryptophan metabolic process (GO:0006568)3.50141613
43positive regulation of Cdc42 GTPase activity (GO:0043089)3.50128067
44negative regulation of transcription regulatory region DNA binding (GO:2000678)3.47539063
45gamma-aminobutyric acid transport (GO:0015812)3.46154975
46axon ensheathment in central nervous system (GO:0032291)3.45506366
47central nervous system myelination (GO:0022010)3.45506366
48dendritic cell differentiation (GO:0097028)3.33927589
49somite development (GO:0061053)3.31761347
50auditory behavior (GO:0031223)3.31223413
51negative regulation of systemic arterial blood pressure (GO:0003085)3.30507780
52regulation of T-helper 1 type immune response (GO:0002825)3.26118639
53positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.26016388
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24771225
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.24771225
56NADH dehydrogenase complex assembly (GO:0010257)3.24771225
57positive regulation of cAMP-mediated signaling (GO:0043950)3.21892201
58regulation of glomerulus development (GO:0090192)3.20480637
59peptide catabolic process (GO:0043171)3.19737846
60piRNA metabolic process (GO:0034587)3.19521611
61regulation of T-helper cell differentiation (GO:0045622)3.17257770
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14668097
63preassembly of GPI anchor in ER membrane (GO:0016254)3.14159362
64indole-containing compound metabolic process (GO:0042430)3.13388892
65proline transport (GO:0015824)3.11534498
66axoneme assembly (GO:0035082)3.10357585
67negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.07983998
68diaphragm development (GO:0060539)3.04742909
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.04372332
703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.04372332
71regulation of gene silencing by RNA (GO:0060966)3.04339076
72regulation of posttranscriptional gene silencing (GO:0060147)3.04339076
73regulation of gene silencing by miRNA (GO:0060964)3.04339076
74bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04254587
75negative regulation of appetite (GO:0032099)3.03503263
76negative regulation of response to food (GO:0032096)3.03503263
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00942535
78positive regulation of fatty acid oxidation (GO:0046321)3.00639886
79DNA methylation involved in gamete generation (GO:0043046)2.99448552
80membrane tubulation (GO:0097320)2.99335505
81positive regulation of heat generation (GO:0031652)2.98478416
82amine catabolic process (GO:0009310)2.98205883
83cellular biogenic amine catabolic process (GO:0042402)2.98205883
84GPI anchor metabolic process (GO:0006505)2.97960392
85response to prostaglandin E (GO:0034695)2.96632373
86otic vesicle formation (GO:0030916)2.96471242
87kidney morphogenesis (GO:0060993)2.94244616
88myeloid dendritic cell activation (GO:0001773)2.93551573
89positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.93035952
90reflex (GO:0060004)2.91960666
91prostaglandin biosynthetic process (GO:0001516)2.91322447
92prostanoid biosynthetic process (GO:0046457)2.91322447
93adhesion of symbiont to host cell (GO:0044650)2.91131384
94virion attachment to host cell (GO:0019062)2.91131384
95regulation of bile acid biosynthetic process (GO:0070857)2.90392732
96regulation of mesoderm development (GO:2000380)2.90228822
97regulation of granulocyte chemotaxis (GO:0071622)2.90080280
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87415602
99protein complex biogenesis (GO:0070271)2.86995561
100axonal fasciculation (GO:0007413)2.86834126
101neuron remodeling (GO:0016322)2.86811754
102transmission of nerve impulse (GO:0019226)2.86532604
103regulation of fever generation (GO:0031620)2.86301665
104detection of light stimulus involved in visual perception (GO:0050908)2.85057419
105detection of light stimulus involved in sensory perception (GO:0050962)2.85057419
106response to nitric oxide (GO:0071731)2.84801220
107positive thymic T cell selection (GO:0045059)2.84680279
108positive regulation of natural killer cell differentiation (GO:0032825)2.83245420
109negative regulation of mast cell activation (GO:0033004)2.83166427
110regulation of hippo signaling (GO:0035330)2.83070104
111response to pheromone (GO:0019236)2.81665958
112multicellular organism reproduction (GO:0032504)2.80313949
113positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77898054
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77423475
115regulation of MHC class II biosynthetic process (GO:0045346)2.77287032
116skeletal muscle organ development (GO:0060538)2.73932044
117primary amino compound metabolic process (GO:1901160)2.73877320
118serotonin metabolic process (GO:0042428)2.73475052
119epithelial cilium movement (GO:0003351)2.70150270
120nonmotile primary cilium assembly (GO:0035058)2.69672648
121platelet dense granule organization (GO:0060155)2.69530520
122neuron recognition (GO:0008038)2.68765074
123regulation of memory T cell differentiation (GO:0043380)2.66549470
124photoreceptor cell development (GO:0042461)2.66471297
125regulation of rhodopsin mediated signaling pathway (GO:0022400)2.66114665
126mitochondrial respiratory chain complex assembly (GO:0033108)2.66033539
127regulation of heat generation (GO:0031650)2.65961157
128tachykinin receptor signaling pathway (GO:0007217)2.64055095
129positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.63752854
130regulation of neutrophil migration (GO:1902622)2.63080671
131regulation of neutrophil chemotaxis (GO:0090022)2.63080671
132positive regulation of receptor biosynthetic process (GO:0010870)2.62921428
133limb bud formation (GO:0060174)2.62624935
134regulation of cellular extravasation (GO:0002691)2.62559851
135thymic T cell selection (GO:0045061)2.61985259
136fusion of sperm to egg plasma membrane (GO:0007342)2.61879382
137rhodopsin mediated signaling pathway (GO:0016056)2.61671011
138replication fork processing (GO:0031297)2.61640202
139positive T cell selection (GO:0043368)2.61243514
140catecholamine biosynthetic process (GO:0042423)2.61178797
141catechol-containing compound biosynthetic process (GO:0009713)2.61178797
142regulation of DNA endoreduplication (GO:0032875)2.60469352
143negative regulation of telomere maintenance (GO:0032205)2.59859345
144regulation of natural killer cell differentiation (GO:0032823)2.59273142
145response to auditory stimulus (GO:0010996)2.58257991
146male meiosis I (GO:0007141)2.58210426
147positive regulation of NF-kappaB import into nucleus (GO:0042346)2.57154218
148regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.56664140
149regulation of acrosome reaction (GO:0060046)2.56504308
150apical protein localization (GO:0045176)2.56502116
151benzene-containing compound metabolic process (GO:0042537)2.55722353
152regulation of collateral sprouting (GO:0048670)2.55686327
153positive regulation of type 2 immune response (GO:0002830)2.55652894
154recombinational repair (GO:0000725)2.54997772
155synapsis (GO:0007129)2.54697345
156positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.54400638
157regulation of phospholipid biosynthetic process (GO:0071071)2.54192233
158double-strand break repair via homologous recombination (GO:0000724)2.54062814
159creatine metabolic process (GO:0006600)2.53975998
160neuronal action potential (GO:0019228)2.52483323
161regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.52315128
162regulation of cell proliferation involved in kidney development (GO:1901722)2.51772604
163flavonoid metabolic process (GO:0009812)2.51758818
164protein K6-linked ubiquitination (GO:0085020)2.51566265
165collecting duct development (GO:0072044)2.51167606
166regulation of action potential (GO:0098900)2.50090658
167behavioral response to ethanol (GO:0048149)2.49762464
168fucose catabolic process (GO:0019317)2.49545627
169L-fucose metabolic process (GO:0042354)2.49545627
170L-fucose catabolic process (GO:0042355)2.49545627
171spinal cord motor neuron differentiation (GO:0021522)2.49138686
172regulation of Golgi to plasma membrane protein transport (GO:0042996)2.48257943
173eye photoreceptor cell development (GO:0042462)2.47129300
174centriole replication (GO:0007099)2.46286071
175positive regulation of interleukin-12 production (GO:0032735)2.46037825
176heterotypic cell-cell adhesion (GO:0034113)2.45628662
177cellular ketone body metabolic process (GO:0046950)2.44717868
178embryonic epithelial tube formation (GO:0001838)2.44707868
179ketone body metabolic process (GO:1902224)2.44659591
180positive regulation of interleukin-4 production (GO:0032753)2.44596001
181regulation of neurotransmitter uptake (GO:0051580)2.44179898
182cellular biogenic amine biosynthetic process (GO:0042401)2.43888607
183amine biosynthetic process (GO:0009309)2.43888607
184mechanosensory behavior (GO:0007638)2.43664816
185biotin metabolic process (GO:0006768)2.43491935
186ATP synthesis coupled proton transport (GO:0015986)2.41419680
187energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41419680
188negative regulation by host of viral transcription (GO:0043922)2.39282491
189aromatic amino acid family catabolic process (GO:0009074)2.39281878
190endoderm formation (GO:0001706)2.39156352
191NAD biosynthetic process (GO:0009435)2.39098543
192regulation of sequestering of triglyceride (GO:0010889)2.38081681
193ubiquinone biosynthetic process (GO:0006744)2.37483289
194negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36821932
195head development (GO:0060322)2.35934260
196cellular anion homeostasis (GO:0030002)2.35432528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.39154482
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64615079
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52586097
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42582786
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39538646
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37363233
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37326992
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.32902708
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31368854
10DROSHA_22980978_ChIP-Seq_HELA_Human2.30770356
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27277719
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27277719
13EWS_26573619_Chip-Seq_HEK293_Human2.24760742
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21860303
15* FUS_26573619_Chip-Seq_HEK293_Human2.15616808
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12186887
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09824679
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09465061
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09365014
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06607227
21AR_21572438_ChIP-Seq_LNCaP_Human2.01488719
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00112627
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98225102
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97759126
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95894152
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95647232
27VDR_22108803_ChIP-Seq_LS180_Human1.95596405
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.89995929
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81466427
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.80094043
31IRF1_19129219_ChIP-ChIP_H3396_Human1.79158259
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76152756
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72076228
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.68967330
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.68957751
36GBX2_23144817_ChIP-Seq_PC3_Human1.64612562
37EZH2_22144423_ChIP-Seq_EOC_Human1.61690657
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.61367833
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56064996
40MYC_18940864_ChIP-ChIP_HL60_Human1.55945133
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55624378
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.55427052
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52611244
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50515283
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.50100565
46* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49812618
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.48990025
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48188554
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.45891011
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43364254
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.42804653
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.38678424
53* AHR_22903824_ChIP-Seq_MCF-7_Human1.37426176
54IGF1R_20145208_ChIP-Seq_DFB_Human1.36921205
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35762154
56* BCAT_22108803_ChIP-Seq_LS180_Human1.35720931
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33604933
58TP53_22573176_ChIP-Seq_HFKS_Human1.32995729
59AR_25329375_ChIP-Seq_VCAP_Human1.32911955
60RNF2_27304074_Chip-Seq_NSC_Mouse1.31741695
61* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31505958
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31503083
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29092693
64SOX2_19829295_ChIP-Seq_ESCs_Human1.28314392
65NANOG_19829295_ChIP-Seq_ESCs_Human1.28314392
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26751766
67VDR_24787735_ChIP-Seq_THP-1_Human1.25067482
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.24222907
69* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24179915
70* FOXA1_25329375_ChIP-Seq_VCAP_Human1.24179915
71GATA1_22025678_ChIP-Seq_K562_Human1.24138400
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.24127214
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23994071
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22936992
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.22073146
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21624057
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.21424438
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21161426
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21158610
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20874907
81EGR1_19032775_ChIP-ChIP_M12_Human1.20448383
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19115219
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18689122
84TAF15_26573619_Chip-Seq_HEK293_Human1.17952770
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17686215
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17430269
87* SMAD4_21741376_ChIP-Seq_EPCs_Human1.16771159
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16128426
89NCOR_22424771_ChIP-Seq_293T_Human1.16005334
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15043620
91* TCF4_22108803_ChIP-Seq_LS180_Human1.14501019
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14433774
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.14194974
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12461622
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12065687
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.10347592
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10154004
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10075156
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08525856
100HOXB7_26014856_ChIP-Seq_BT474_Human1.08504315
101* RUNX2_22187159_ChIP-Seq_PCA_Human1.08304804
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.07218993
103* FOXO3_23340844_ChIP-Seq_DLD1_Human1.07169086
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06968067
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.06292422
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06269727
107SMAD4_21799915_ChIP-Seq_A2780_Human1.05933827
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05834303
109RING1B_27294783_Chip-Seq_NPCs_Mouse1.05554713
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04954129
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04599539
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.04247411
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04081435
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03881253
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.02597752
116P300_19829295_ChIP-Seq_ESCs_Human1.02475927
117TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02024786
118ELK1_19687146_ChIP-ChIP_HELA_Human1.02009097
119* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01514948
120ER_23166858_ChIP-Seq_MCF-7_Human1.01271836
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.00185296
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99328034
123* AR_20517297_ChIP-Seq_VCAP_Human0.98797344
124RUNX_20019798_ChIP-Seq_JUKART_Human0.98549838
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98397216
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96928708
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96874126
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95306907
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94862429
130* P53_22387025_ChIP-Seq_ESCs_Mouse0.94693960
131* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93856625
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93636686
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.93616299
134* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93259289
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92630223
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91777371
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.91761429
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91315513
139CBP_20019798_ChIP-Seq_JUKART_Human0.91315513
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89238908
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88807320
142* REST_21632747_ChIP-Seq_MESCs_Mouse0.88122609
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87330751
144* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87073045
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86990732
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86990732
147SMRT_27268052_Chip-Seq_Bcells_Human0.86736935
148* TCF4_23295773_ChIP-Seq_U87_Human0.86732794
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86715064
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85870086
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85849188
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85581533
153* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84896828
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84672997
155* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83833721
156RXR_22108803_ChIP-Seq_LS180_Human0.82591199
157* NANOG_18555785_Chip-Seq_ESCs_Mouse0.82381346
158* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82356846
159* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82302956
160* STAT3_23295773_ChIP-Seq_U87_Human0.81792813
161* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81627814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology5.32387041
2MP0001348_abnormal_lacrimal_gland5.18683365
3MP0001346_abnormal_lacrimal_gland4.47421265
4MP0005645_abnormal_hypothalamus_physiol4.23465390
5MP0000685_abnormal_immune_system4.16729479
6MP0001873_stomach_inflammation3.54723523
7MP0005310_abnormal_salivary_gland3.40464362
8MP0003879_abnormal_hair_cell3.30970568
9MP0003646_muscle_fatigue3.11285386
10MP0006292_abnormal_olfactory_placode3.07730742
11MP0004510_myositis2.84312097
12MP0006082_CNS_inflammation2.76096052
13MP0003136_yellow_coat_color2.74040892
14MP0000372_irregular_coat_pigmentation2.69413353
15MP0005646_abnormal_pituitary_gland2.53336639
16MP0002102_abnormal_ear_morphology2.48059568
17MP0002837_dystrophic_cardiac_calcinosis2.42905993
18MP0002735_abnormal_chemical_nociception2.38778499
19MP0005551_abnormal_eye_electrophysiolog2.27199028
20MP0001835_abnormal_antigen_presentation2.22721413
21MP0001485_abnormal_pinna_reflex2.13625840
22MP0008877_abnormal_DNA_methylation2.13082566
23MP0005671_abnormal_response_to2.10809810
24MP0002254_reproductive_system_inflammat10.5627539
25MP0000631_abnormal_neuroendocrine_gland1.98501151
26MP0001968_abnormal_touch/_nociception1.97374202
27MP0002653_abnormal_ependyma_morphology1.94775771
28MP0004142_abnormal_muscle_tone1.90413215
29MP0002160_abnormal_reproductive_system1.82253896
30MP0004145_abnormal_muscle_electrophysio1.81668088
31MP0002138_abnormal_hepatobiliary_system1.74417183
32MP0005647_abnormal_sex_gland1.70514786
33MP0002938_white_spotting1.66423088
34MP0000049_abnormal_middle_ear1.62589874
35MP0002736_abnormal_nociception_after1.61915262
36MP0002638_abnormal_pupillary_reflex1.61860578
37MP0004133_heterotaxia1.56157851
38MP0003011_delayed_dark_adaptation1.54279519
39MP0005253_abnormal_eye_physiology1.53658967
40MP0001790_abnormal_immune_system1.52566869
41MP0005387_immune_system_phenotype1.52566869
42MP0002822_catalepsy1.52526719
43MP0005171_absent_coat_pigmentation1.51463525
44MP0003763_abnormal_thymus_physiology1.49037282
45MP0010678_abnormal_skin_adnexa1.48228953
46MP0002877_abnormal_melanocyte_morpholog1.44488565
47MP0002163_abnormal_gland_morphology1.42049556
48MP0005389_reproductive_system_phenotype1.40242368
49MP0008789_abnormal_olfactory_epithelium1.38914334
50MP0004134_abnormal_chest_morphology1.37400387
51MP0000383_abnormal_hair_follicle1.35863106
52MP0006276_abnormal_autonomic_nervous1.35515060
53MP0006072_abnormal_retinal_apoptosis1.29680773
54MP0001986_abnormal_taste_sensitivity1.27402545
55MP0001851_eye_inflammation1.27198584
56MP0000613_abnormal_salivary_gland1.26598040
57MP0005084_abnormal_gallbladder_morpholo1.25938983
58MP0001501_abnormal_sleep_pattern1.24439307
59MP0004147_increased_porphyrin_level1.23850451
60MP0005174_abnormal_tail_pigmentation1.23282606
61MP0010234_abnormal_vibrissa_follicle1.22378992
62MP0002733_abnormal_thermal_nociception1.22375470
63MP0002277_abnormal_respiratory_mucosa1.20396392
64MP0003718_maternal_effect1.19842767
65MP0004742_abnormal_vestibular_system1.18715726
66MP0002095_abnormal_skin_pigmentation1.16380449
67MP0003890_abnormal_embryonic-extraembry1.16295045
68MP0002734_abnormal_mechanical_nocicepti1.16247751
69MP0003045_fibrosis1.15788077
70MP0003119_abnormal_digestive_system1.15512962
71MP0000920_abnormal_myelination1.14789565
72MP0001293_anophthalmia1.13945932
73MP0001984_abnormal_olfaction1.13476714
74MP0005410_abnormal_fertilization1.13305692
75MP0004885_abnormal_endolymph1.11906831
76MP0002928_abnormal_bile_duct1.11620644
77MP0003937_abnormal_limbs/digits/tail_de1.11382663
78MP0003938_abnormal_ear_development1.07874914
79MP0005075_abnormal_melanosome_morpholog1.06685691
80MP0003880_abnormal_central_pattern1.06084657
81MP0000427_abnormal_hair_cycle1.05906673
82MP0004859_abnormal_synaptic_plasticity1.03255252
83MP0003300_gastrointestinal_ulcer1.01606293
84MP0005195_abnormal_posterior_eye1.01084650
85MP0008875_abnormal_xenobiotic_pharmacok1.00543894
86MP0003283_abnormal_digestive_organ0.98390248
87MP0001970_abnormal_pain_threshold0.97077733
88MP0004043_abnormal_pH_regulation0.96722439
89MP0005377_hearing/vestibular/ear_phenot0.96499880
90MP0003878_abnormal_ear_physiology0.96499880
91MP0008569_lethality_at_weaning0.94995616
92MP0009250_abnormal_appendicular_skeleto0.94980685
93MP0002557_abnormal_social/conspecific_i0.94781326
94MP0010386_abnormal_urinary_bladder0.93658639
95MP0002752_abnormal_somatic_nervous0.93348117
96MP0009379_abnormal_foot_pigmentation0.90915609
97MP0002751_abnormal_autonomic_nervous0.90741565
98MP0004130_abnormal_muscle_cell0.90737945
99MP0005499_abnormal_olfactory_system0.89210678
100MP0005394_taste/olfaction_phenotype0.89210678
101MP0003787_abnormal_imprinting0.88826095
102MP0002234_abnormal_pharynx_morphology0.88410718
103MP0001324_abnormal_eye_pigmentation0.88154378
104MP0000230_abnormal_systemic_arterial0.87171341
105MP0000569_abnormal_digit_pigmentation0.87045461
106MP0005379_endocrine/exocrine_gland_phen0.86704721
107MP0003183_abnormal_peptide_metabolism0.86491535
108MP0001800_abnormal_humoral_immune0.86243482
109MP0002282_abnormal_trachea_morphology0.85146041
110MP0001963_abnormal_hearing_physiology0.85105741
111MP0001905_abnormal_dopamine_level0.84891115
112MP0001486_abnormal_startle_reflex0.84820804
113MP0002210_abnormal_sex_determination0.83969056
114MP0000470_abnormal_stomach_morphology0.83167105
115MP0001919_abnormal_reproductive_system0.83078525
116MP0004381_abnormal_hair_follicle0.82743059
117MP0003195_calcinosis0.82078416
118MP0002067_abnormal_sensory_capabilities0.81717274
119MP0005000_abnormal_immune_tolerance0.81697336
120MP0001929_abnormal_gametogenesis0.81483653
121MP0008058_abnormal_DNA_repair0.80175475
122MP0003638_abnormal_response/metabolism_0.79217209
123MP0002272_abnormal_nervous_system0.78564567
124MP0000026_abnormal_inner_ear0.76227621
125MP0003329_amyloid_beta_deposits0.76123845
126MP0004270_analgesia0.74149141
127MP0009745_abnormal_behavioral_response0.69717035
128MP0003453_abnormal_keratinocyte_physiol0.67157580
129MP0009046_muscle_twitch0.66634062
130MP0001502_abnormal_circadian_rhythm0.64892400
131MP0005451_abnormal_body_composition0.64124372
132MP0009384_cardiac_valve_regurgitation0.64102180
133MP0002148_abnormal_hypersensitivity_rea0.63643063
134MP0002063_abnormal_learning/memory/cond0.63031570
135MP0010155_abnormal_intestine_physiology0.62571471
136MP0000516_abnormal_urinary_system0.61950721
137MP0005367_renal/urinary_system_phenotyp0.61950721
138MP0003172_abnormal_lysosome_physiology0.61092873
139MP0000604_amyloidosis0.60930788
140MP0001881_abnormal_mammary_gland0.59920359
141MP0009333_abnormal_splenocyte_physiolog0.59628149
142MP0000778_abnormal_nervous_system0.58477792
143MP0002405_respiratory_system_inflammati0.57604862
144MP0001529_abnormal_vocalization0.56738104
145MP0001663_abnormal_digestive_system0.55431063
146MP0000003_abnormal_adipose_tissue0.54714369
147MP0003635_abnormal_synaptic_transmissio0.54045367
148MP0001440_abnormal_grooming_behavior0.53202864
149MP0008872_abnormal_physiological_respon0.52754027
150MP0001845_abnormal_inflammatory_respons0.52324701
151MP0002064_seizures0.52199884
152MP0002693_abnormal_pancreas_physiology0.51649948
153MP0005025_abnormal_response_to0.51339017
154MP0008004_abnormal_stomach_pH0.50901211
155MP0009765_abnormal_xenobiotic_induced0.50361983
156MP0003866_abnormal_defecation0.49109922
157MP0002572_abnormal_emotion/affect_behav0.49001214
158MP0008775_abnormal_heart_ventricle0.48194129
159MP0002723_abnormal_immune_serum0.48176845
160MP0001819_abnormal_immune_cell0.48076872
161MP0002420_abnormal_adaptive_immunity0.47617837
162MP0002452_abnormal_antigen_presenting0.46974565
163MP0004782_abnormal_surfactant_physiolog0.46933278
164MP0004947_skin_inflammation0.45417642
165MP0005535_abnormal_body_temperature0.44119411
166MP0005381_digestive/alimentary_phenotyp0.43866081
167MP0000538_abnormal_urinary_bladder0.43548789
168MP0000716_abnormal_immune_system0.41749370
169MP0002972_abnormal_cardiac_muscle0.41568769
170MP0003137_abnormal_impulse_conducting0.41148398
171MP0008874_decreased_physiological_sensi0.39709688
172MP0002971_abnormal_brown_adipose0.39496441
173MP0003448_altered_tumor_morphology0.39383411

Predicted human phenotypes

RankGene SetZ-score
1Chronic mucocutaneous candidiasis (HP:0002728)7.99889781
2Recurrent cutaneous fungal infections (HP:0011370)7.99889781
3Aplasia/Hypoplasia of the spleen (HP:0010451)7.47351000
4Keratoconjunctivitis (HP:0001096)6.59256202
5Asplenia (HP:0001746)6.38980141
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.96766737
7Pancreatic cysts (HP:0001737)4.60236726
8Hypercortisolism (HP:0001578)4.57924817
9Type I diabetes mellitus (HP:0100651)4.39428862
10Increased IgE level (HP:0003212)4.38277802
11Abnormal auditory evoked potentials (HP:0006958)4.31170687
12Recurrent fungal infections (HP:0002841)4.27616427
13Pancreatic fibrosis (HP:0100732)4.09690214
14Recurrent skin infections (HP:0001581)4.06059293
15Pendular nystagmus (HP:0012043)3.85949061
16True hermaphroditism (HP:0010459)3.84374892
17Congenital stationary night blindness (HP:0007642)3.78144004
18Abnormality of the gastric mucosa (HP:0004295)3.74260282
19Nephronophthisis (HP:0000090)3.62604888
20Upper limb muscle weakness (HP:0003484)3.56099236
21Neurofibrillary tangles (HP:0002185)3.51310057
22Abnormal pupillary function (HP:0007686)3.44477123
23Onion bulb formation (HP:0003383)3.40412611
24Prolonged neonatal jaundice (HP:0006579)3.35884536
25Abnormality of midbrain morphology (HP:0002418)3.33175266
26Molar tooth sign on MRI (HP:0002419)3.33175266
27Type 2 muscle fiber atrophy (HP:0003554)3.25791496
28Eczematoid dermatitis (HP:0000976)3.20648452
29Abolished electroretinogram (ERG) (HP:0000550)3.19014421
30Right ventricular cardiomyopathy (HP:0011663)3.18627045
31Genetic anticipation (HP:0003743)3.15712781
32Abnormality of the renal cortex (HP:0011035)3.12581958
33Abnormality of the renal medulla (HP:0100957)3.10755747
34Hypoparathyroidism (HP:0000829)3.08839321
353-Methylglutaconic aciduria (HP:0003535)3.02895935
36Abnormality of proline metabolism (HP:0010907)3.02570816
37Hydroxyprolinuria (HP:0003080)3.02570816
38Hypoplasia of dental enamel (HP:0006297)3.00571109
39Hypoplasia of the uterus (HP:0000013)3.00512623
40Confusion (HP:0001289)3.00505028
41Type II lissencephaly (HP:0007260)2.97006532
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.92374956
43Unilateral renal agenesis (HP:0000122)2.90644476
44Fatigable weakness (HP:0003473)2.88741288
45Abnormality of the neuromuscular junction (HP:0003398)2.88741288
46Weak cry (HP:0001612)2.85906519
47Inflammation of the large intestine (HP:0002037)2.85576166
48Attenuation of retinal blood vessels (HP:0007843)2.82396514
49Abnormal rod and cone electroretinograms (HP:0008323)2.78545038
50Muscle fiber atrophy (HP:0100295)2.77678520
51Hepatitis (HP:0012115)2.77286405
52Gastrointestinal stroma tumor (HP:0100723)2.76349359
53Progressive cerebellar ataxia (HP:0002073)2.73026392
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.73007491
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73007491
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71710101
57Tubular atrophy (HP:0000092)2.70916707
58Adrenal overactivity (HP:0002717)2.70809165
59Septo-optic dysplasia (HP:0100842)2.70713576
60Onycholysis (HP:0001806)2.70404664
61Cystic liver disease (HP:0006706)2.70391152
62Keratitis (HP:0000491)2.70223018
63Cholelithiasis (HP:0001081)2.63228996
64Keratoconus (HP:0000563)2.63010868
65Increased corneal curvature (HP:0100692)2.63010868
66Agammaglobulinemia (HP:0004432)2.62362830
67Methylmalonic acidemia (HP:0002912)2.61084769
68Cerebral inclusion bodies (HP:0100314)2.60795480
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.60444560
70Truncus arteriosus (HP:0001660)2.57289384
71Plantar hyperkeratosis (HP:0007556)2.54223381
72Agitation (HP:0000713)2.48529308
73Amelogenesis imperfecta (HP:0000705)2.48283471
74Gastrointestinal inflammation (HP:0004386)2.48192582
75Abnormal gallbladder morphology (HP:0012437)2.47803129
76Congenital, generalized hypertrichosis (HP:0004540)2.47634640
77Pustule (HP:0200039)2.47055391
78Renal cortical cysts (HP:0000803)2.41880796
79Congenital sensorineural hearing impairment (HP:0008527)2.39770797
80Chronic hepatic failure (HP:0100626)2.38119189
81Furrowed tongue (HP:0000221)2.36499502
82Villous atrophy (HP:0011473)2.35888238
83Abnormality of small intestinal villus morphology (HP:0011472)2.35888238
84Annular pancreas (HP:0001734)2.35871438
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.34643183
86Sclerocornea (HP:0000647)2.34075620
87Anencephaly (HP:0002323)2.33760118
88Optic nerve hypoplasia (HP:0000609)2.33479130
89Colitis (HP:0002583)2.32421792
90Tongue fasciculations (HP:0001308)2.31351426
91Abnormal pancreas size (HP:0012094)2.29929796
92Interstitial pulmonary disease (HP:0006530)2.29033555
93Gaze-evoked nystagmus (HP:0000640)2.28661142
94Xerostomia (HP:0000217)2.28474391
95Abnormality of the renal collecting system (HP:0004742)2.24793121
96Medial flaring of the eyebrow (HP:0010747)2.24667843
97Methylmalonic aciduria (HP:0012120)2.24221610
98Acute necrotizing encephalopathy (HP:0006965)2.24194944
99Double outlet right ventricle (HP:0001719)2.24139693
100Congenital malformation of the right heart (HP:0011723)2.24139693
101Chorioretinal atrophy (HP:0000533)2.22453540
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.22123691
103Abnormal drinking behavior (HP:0030082)2.20850165
104Polydipsia (HP:0001959)2.20850165
105Seborrheic dermatitis (HP:0001051)2.20618259
106Lip pit (HP:0100267)2.20022596
107Aplasia/Hypoplasia of the uvula (HP:0010293)2.19713396
108Supranuclear gaze palsy (HP:0000605)2.19596827
109Severe visual impairment (HP:0001141)2.19327286
110Aplasia/Hypoplasia of the tongue (HP:0010295)2.16523073
111Palmoplantar hyperkeratosis (HP:0000972)2.15470323
112Muscle fibrillation (HP:0010546)2.08555345
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07498882
114Abnormality of alanine metabolism (HP:0010916)2.07498882
115Hyperalaninemia (HP:0003348)2.07498882
116Nasal polyposis (HP:0100582)2.07229464
117Abnormality of the corticospinal tract (HP:0002492)2.06448810
118Male pseudohermaphroditism (HP:0000037)2.05934323
119Mitochondrial inheritance (HP:0001427)2.03760090
120Bilateral microphthalmos (HP:0007633)2.02931917
121Congenital hepatic fibrosis (HP:0002612)2.02767486
122Milia (HP:0001056)2.02680390
123Absent thumb (HP:0009777)2.01317870
124Aplasia/hypoplasia of the uterus (HP:0008684)2.00727243
125Decreased central vision (HP:0007663)2.00383554
126Concave nail (HP:0001598)1.99479776
127Hypergammaglobulinemia (HP:0010702)1.98501726
128Acute encephalopathy (HP:0006846)1.98496722
129Progressive macrocephaly (HP:0004481)1.98056809
130Chronic otitis media (HP:0000389)1.95889553
131Abnormal ciliary motility (HP:0012262)1.95769820
132Abnormality of the phalanges of the 2nd finger (HP:0009541)1.95178946
133Conical tooth (HP:0000698)1.95169948
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.93906019
135Hypoplasia of the fovea (HP:0007750)1.93906019
136Palmar hyperkeratosis (HP:0010765)1.92585640
137Increased CSF lactate (HP:0002490)1.91983916
138Panhypogammaglobulinemia (HP:0003139)1.91912247
139Thyroid-stimulating hormone excess (HP:0002925)1.91666829
140Cerebellar dysplasia (HP:0007033)1.90912221
141Abnormality of oral frenula (HP:0000190)1.90528488
142Short tibia (HP:0005736)1.90189027
143Abnormal mitochondria in muscle tissue (HP:0008316)1.87556914
144Abnormal respiratory epithelium morphology (HP:0012253)1.87296837
145Abnormal respiratory motile cilium morphology (HP:0005938)1.87296837
146Metabolic alkalosis (HP:0200114)1.87284983
147Abnormality of the ileum (HP:0001549)1.86971754
148Absent/shortened dynein arms (HP:0200106)1.85890798
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.85890798
150Postaxial foot polydactyly (HP:0001830)1.85847026
151Meckel diverticulum (HP:0002245)1.84399733
152Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84318998
153Aplasia/Hypoplasia of the patella (HP:0006498)1.81866126
154Abnormality of the phalanges of the 5th finger (HP:0004213)1.81587141
155Small hand (HP:0200055)1.81565363
156Myokymia (HP:0002411)1.80127825
157Premature loss of primary teeth (HP:0006323)1.78801706
158Anosmia (HP:0000458)1.77503304
159Emphysema (HP:0002097)1.77304276
160Easy fatigability (HP:0003388)1.76802971
161Abnormality of DNA repair (HP:0003254)1.76686394
162Polyuria (HP:0000103)1.76635324
163Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76617233
164Abnormal number of erythroid precursors (HP:0012131)1.76574854
165Genital tract atresia (HP:0001827)1.76395101
166Inability to walk (HP:0002540)1.75360490
167Lissencephaly (HP:0001339)1.73978224
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.73552405
169Abnormality of the aortic arch (HP:0012303)1.73408846
170Abnormality of chromosome stability (HP:0003220)1.72199351
171Bony spicule pigmentary retinopathy (HP:0007737)1.72144200
172Recurrent gram-negative bacterial infections (HP:0005420)1.71811665
173Severe muscular hypotonia (HP:0006829)1.70933834
174Stenosis of the external auditory canal (HP:0000402)1.70694648
175Vaginal atresia (HP:0000148)1.70366168
176Optic disc pallor (HP:0000543)1.68725863
177Hemiparesis (HP:0001269)1.68396902
178Abnormal respiratory motile cilium physiology (HP:0012261)1.67892053
179Decreased circulating renin level (HP:0003351)1.67243022
180Pachygyria (HP:0001302)1.66654953
181Gait imbalance (HP:0002141)1.66483996
182Recurrent pneumonia (HP:0006532)1.66395280
183Focal motor seizures (HP:0011153)1.66376253
184Ventricular tachycardia (HP:0004756)1.66284288
185Duplicated collecting system (HP:0000081)1.63552066
186Amniotic constriction ring (HP:0009775)1.60299243
187Abnormality of placental membranes (HP:0011409)1.60299243
188Abnormality of the gallbladder (HP:0005264)1.59188665
189Maternal diabetes (HP:0009800)1.58915602
190Ankyloglossia (HP:0010296)1.58149011
191Choroideremia (HP:0001139)1.57899042
192Increased circulating renin level (HP:0000848)1.57127678
193Symphalangism affecting the phalanges of the hand (HP:0009773)1.55073081
194Peripheral hypomyelination (HP:0007182)1.54924347

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.37532718
2FRK5.04196696
3ADRBK23.55560783
4EPHB13.37445837
5MST43.25039036
6EPHA33.22618621
7WNK32.93030486
8TAOK32.80467872
9MAP4K22.72004911
10STK392.69261292
11ZAK2.60933145
12MAP3K132.54098957
13PKN12.39759361
14NME12.37876498
15PINK12.37851369
16ACVR1B2.29624793
17FGFR42.21548666
18DYRK32.16104904
19CDC42BPA1.99712426
20TLK11.93246346
21BCR1.82784716
22ITK1.79971828
23MAPK131.75004706
24TNIK1.71467555
25IRAK31.70998890
26OXSR11.62786303
27WNK41.56457044
28STK38L1.54947677
29DYRK1B1.53627846
30TRIM281.52170192
31JAK31.50367523
32AKT31.50100923
33MAP3K41.49935617
34IKBKE1.43199106
35TIE11.43050866
36JAK11.42966335
37IRAK41.35793695
38MAP3K71.35214605
39CLK11.34373026
40PRKCQ1.34168130
41PRPF4B1.30030170
42EPHA21.29315823
43BMPR21.20233364
44FGFR31.19720511
45VRK11.16595411
46TYK21.16348760
47EPHA41.15579781
48ADRBK11.13068870
49TXK1.12999213
50NTRK11.09800079
51ROCK21.08713507
52STK101.07840444
53GRK51.07467424
54CHUK1.07258250
55PRKCG1.07134779
56IKBKB1.03132808
57PLK21.00931874
58NLK1.00646196
59PRKD20.99039716
60CDC70.97424714
61MKNK20.96992781
62PAK30.96136825
63OBSCN0.93860183
64MYLK0.93304378
65MAP2K70.92615691
66TGFBR10.91710056
67PLK40.91044099
68TEC0.90793634
69VRK20.88637357
70DDR20.87553260
71PTK60.84940518
72MAPKAPK30.84260442
73JAK20.84111031
74DYRK1A0.84093174
75STK30.81077292
76STK160.80596686
77LIMK10.80210730
78TBK10.79811356
79BMPR1B0.78169591
80SYK0.76732745
81MUSK0.76124231
82CSNK1G20.72957314
83CSNK1G30.71642483
84CSNK1G10.69941918
85NUAK10.69284180
86MAPK150.68747200
87CASK0.68320919
88PAK60.68239860
89WEE10.67734242
90HCK0.67369459
91PRKAA20.65647563
92PLK30.65031242
93PTK20.64859648
94TRPM70.64054124
95DAPK20.63802790
96FYN0.63537450
97MAP4K10.63515078
98PTK2B0.63482975
99PRKCE0.63011978
100RPS6KA50.62542712
101TYRO30.61108485
102IRAK10.61087320
103LCK0.60361563
104NTRK20.60033738
105MARK10.59244128
106MAP2K10.58606831
107BTK0.57759117
108CSNK1A10.57419843
109BCKDK0.57179037
110CAMK2B0.57079543
111PNCK0.57074376
112TAF10.56837667
113FER0.56523440
114STK110.55173812
115LRRK20.54450437
116TESK10.54050435
117PRKACA0.54044003
118CAMK2G0.53196307
119SGK10.52811277
120SRC0.52709172
121LATS10.52647309
122MKNK10.52489442
123CDK50.52457740
124LMTK20.51343004
125STK240.50717958
126TNK20.50155498
127PLK10.49779235
128EIF2AK20.49617450
129ATR0.49575985
130MAP2K20.48937899
131CSNK1A1L0.47917518
132EIF2AK30.47616050
133PRKCH0.47227791
134ALK0.45565188
135PRKCI0.43705992
136MATK0.43271751
137GRK10.42208876
138FGFR20.42031312
139GRK70.41760533
140ERBB20.41759175
141ERBB30.41642405
142INSRR0.41314218
143NTRK30.40933394
144DYRK20.40703997
145CAMK2A0.40686761
146EGFR0.40367500
147CHEK20.40352098
148PRKCD0.40326382
149PRKCZ0.40073949
150SIK30.39592588
151MAPKAPK50.38799317
152PRKCA0.37666100
153INSR0.37582375
154MAP3K100.37340572
155PHKG10.36051921
156PHKG20.36051921
157GRK60.35556287
158CSNK1D0.33185294
159MARK30.31505231
160IGF1R0.30866597
161BRSK20.29739690

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.91814693
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32498194
3Histidine metabolism_Homo sapiens_hsa003403.17766136
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.04695969
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95285022
6Phototransduction_Homo sapiens_hsa047442.83789505
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.73492499
8Homologous recombination_Homo sapiens_hsa034402.52567785
9Oxidative phosphorylation_Homo sapiens_hsa001902.41077011
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.32422957
11RNA polymerase_Homo sapiens_hsa030202.12779797
12Autoimmune thyroid disease_Homo sapiens_hsa053202.03178315
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.00365327
14Parkinsons disease_Homo sapiens_hsa050122.00039979
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97240015
16Antigen processing and presentation_Homo sapiens_hsa046121.96066867
17Basal transcription factors_Homo sapiens_hsa030221.95593769
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.89518664
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88887208
20Tryptophan metabolism_Homo sapiens_hsa003801.78948901
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.77258893
22Fanconi anemia pathway_Homo sapiens_hsa034601.75066007
23Butanoate metabolism_Homo sapiens_hsa006501.74956053
24Asthma_Homo sapiens_hsa053101.63702487
25Selenocompound metabolism_Homo sapiens_hsa004501.60243537
26Allograft rejection_Homo sapiens_hsa053301.58176299
27Olfactory transduction_Homo sapiens_hsa047401.51556167
28Nicotine addiction_Homo sapiens_hsa050331.49729108
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49208287
30Protein export_Homo sapiens_hsa030601.49151713
31Phenylalanine metabolism_Homo sapiens_hsa003601.47833217
32Amphetamine addiction_Homo sapiens_hsa050311.45010433
33Ribosome_Homo sapiens_hsa030101.44812498
34Huntingtons disease_Homo sapiens_hsa050161.37945945
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35562443
36Chemical carcinogenesis_Homo sapiens_hsa052041.34287712
37African trypanosomiasis_Homo sapiens_hsa051431.29407430
38Caffeine metabolism_Homo sapiens_hsa002321.28619519
39Alzheimers disease_Homo sapiens_hsa050101.26282167
40Leishmaniasis_Homo sapiens_hsa051401.25582426
41Cocaine addiction_Homo sapiens_hsa050301.23936677
42Morphine addiction_Homo sapiens_hsa050321.20830826
43Glutamatergic synapse_Homo sapiens_hsa047241.20425962
44Salivary secretion_Homo sapiens_hsa049701.19680329
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19013103
46Serotonergic synapse_Homo sapiens_hsa047261.18432544
47RNA degradation_Homo sapiens_hsa030181.18304953
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15952360
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15500513
50Chemokine signaling pathway_Homo sapiens_hsa040621.14731971
51Ether lipid metabolism_Homo sapiens_hsa005651.14695988
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14394151
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.13422111
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11447310
55Calcium signaling pathway_Homo sapiens_hsa040201.10171171
56One carbon pool by folate_Homo sapiens_hsa006701.10019716
57T cell receptor signaling pathway_Homo sapiens_hsa046601.08374904
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06405366
59Sulfur metabolism_Homo sapiens_hsa009201.06248531
60Arachidonic acid metabolism_Homo sapiens_hsa005901.05440440
61Axon guidance_Homo sapiens_hsa043601.05368092
62Osteoclast differentiation_Homo sapiens_hsa043801.02031387
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.01406403
64Gastric acid secretion_Homo sapiens_hsa049711.01098153
65Glycerolipid metabolism_Homo sapiens_hsa005611.00744950
66Retinol metabolism_Homo sapiens_hsa008301.00192677
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99358835
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98477863
69GABAergic synapse_Homo sapiens_hsa047270.97518291
70Linoleic acid metabolism_Homo sapiens_hsa005910.95094263
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.93687985
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92222826
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89217185
74ABC transporters_Homo sapiens_hsa020100.89071292
75Fat digestion and absorption_Homo sapiens_hsa049750.88700301
76Circadian entrainment_Homo sapiens_hsa047130.87644040
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85238210
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85235802
79Graft-versus-host disease_Homo sapiens_hsa053320.83722418
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83104206
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82064333
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79882462
83Long-term potentiation_Homo sapiens_hsa047200.79687643
84Renin secretion_Homo sapiens_hsa049240.79501997
85Rheumatoid arthritis_Homo sapiens_hsa053230.78849415
86Peroxisome_Homo sapiens_hsa041460.78025371
87Purine metabolism_Homo sapiens_hsa002300.77101213
88Toxoplasmosis_Homo sapiens_hsa051450.76756944
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76638330
90Sphingolipid metabolism_Homo sapiens_hsa006000.75499303
91beta-Alanine metabolism_Homo sapiens_hsa004100.74506269
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73973913
93Tight junction_Homo sapiens_hsa045300.73629805
94Cholinergic synapse_Homo sapiens_hsa047250.73187074
95Dorso-ventral axis formation_Homo sapiens_hsa043200.72892331
96Non-homologous end-joining_Homo sapiens_hsa034500.72720723
97Type I diabetes mellitus_Homo sapiens_hsa049400.72495371
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72295703
99Thyroid hormone synthesis_Homo sapiens_hsa049180.72255341
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72206955
101B cell receptor signaling pathway_Homo sapiens_hsa046620.69804344
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68565478
103Propanoate metabolism_Homo sapiens_hsa006400.68525844
104MAPK signaling pathway_Homo sapiens_hsa040100.68219498
105cAMP signaling pathway_Homo sapiens_hsa040240.67093054
106Dilated cardiomyopathy_Homo sapiens_hsa054140.67069519
107Ovarian steroidogenesis_Homo sapiens_hsa049130.66540824
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.66465745
109Insulin secretion_Homo sapiens_hsa049110.66331111
110Taste transduction_Homo sapiens_hsa047420.65714706
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65712807
112Melanoma_Homo sapiens_hsa052180.65693954
113Ras signaling pathway_Homo sapiens_hsa040140.63451687
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.62152325
115Pyrimidine metabolism_Homo sapiens_hsa002400.61720588
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59157084
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.59137752
118Nucleotide excision repair_Homo sapiens_hsa034200.58844964
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.58124799
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57192362
121Synaptic vesicle cycle_Homo sapiens_hsa047210.57046726
122Nitrogen metabolism_Homo sapiens_hsa009100.57042266
123Metabolic pathways_Homo sapiens_hsa011000.56020092
124Cardiac muscle contraction_Homo sapiens_hsa042600.54561787
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54534760
126Tyrosine metabolism_Homo sapiens_hsa003500.54410267
127Systemic lupus erythematosus_Homo sapiens_hsa053220.52868746
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52607230
129Mismatch repair_Homo sapiens_hsa034300.51960255
130Oxytocin signaling pathway_Homo sapiens_hsa049210.51868705
131Regulation of autophagy_Homo sapiens_hsa041400.51783808
132Vitamin digestion and absorption_Homo sapiens_hsa049770.51059232
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50789350
134Proteasome_Homo sapiens_hsa030500.50761255
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50197703
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49847039
137Tuberculosis_Homo sapiens_hsa051520.49638932
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47979191
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47593661
140Steroid biosynthesis_Homo sapiens_hsa001000.46348711
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.45637854
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45207386
143TNF signaling pathway_Homo sapiens_hsa046680.44247338
144Measles_Homo sapiens_hsa051620.43770992
145Basal cell carcinoma_Homo sapiens_hsa052170.43654948
146Viral myocarditis_Homo sapiens_hsa054160.42535021
147Choline metabolism in cancer_Homo sapiens_hsa052310.41836654
148Rap1 signaling pathway_Homo sapiens_hsa040150.41355048
149Vibrio cholerae infection_Homo sapiens_hsa051100.39994574
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39865267
151Pancreatic cancer_Homo sapiens_hsa052120.39802944
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.39635634
153Small cell lung cancer_Homo sapiens_hsa052220.38310168
154Collecting duct acid secretion_Homo sapiens_hsa049660.38166707
155Dopaminergic synapse_Homo sapiens_hsa047280.37806752
156Pathways in cancer_Homo sapiens_hsa052000.37030290
157Hedgehog signaling pathway_Homo sapiens_hsa043400.36804854
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36784595
159Long-term depression_Homo sapiens_hsa047300.34707678
160DNA replication_Homo sapiens_hsa030300.34632083
161Fatty acid biosynthesis_Homo sapiens_hsa000610.32669770
162RNA transport_Homo sapiens_hsa030130.31598429

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