MYO5BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)7.59439341
2positive regulation of interferon-gamma biosynthetic process (GO:0045078)7.44273959
3cellular response to zinc ion (GO:0071294)6.59937553
4positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.57309067
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.55000963
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.55000963
7hydrogen peroxide biosynthetic process (GO:0050665)6.51946076
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.95943595
9positive regulation of macrophage cytokine production (GO:0060907)5.77425212
10reactive oxygen species biosynthetic process (GO:1903409)5.71773915
11regulation of interferon-gamma biosynthetic process (GO:0045072)5.49659222
12regulation of germinal center formation (GO:0002634)5.42003663
13B cell receptor signaling pathway (GO:0050853)5.10228152
14neutrophil activation involved in immune response (GO:0002283)4.79742647
15positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.78641517
16respiratory burst (GO:0045730)4.77909265
17DNA damage response, detection of DNA damage (GO:0042769)4.60098530
18I-kappaB phosphorylation (GO:0007252)4.58955018
19positive regulation of interferon-alpha production (GO:0032727)4.54924390
20positive regulation of protein kinase C signaling (GO:0090037)4.48220433
21superoxide anion generation (GO:0042554)4.44340154
22regulation of macrophage cytokine production (GO:0010935)4.40156119
23regulation of hippo signaling (GO:0035330)4.30564535
24dermatan sulfate metabolic process (GO:0030205)4.19159399
25negative regulation of cAMP-mediated signaling (GO:0043951)4.14956797
26poly(A)+ mRNA export from nucleus (GO:0016973)4.11997416
27regulation of interferon-alpha production (GO:0032647)4.10222912
28regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.08780578
29branching involved in labyrinthine layer morphogenesis (GO:0060670)4.06534786
30regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.00773252
31regulation of hexokinase activity (GO:1903299)3.94917731
32regulation of glucokinase activity (GO:0033131)3.94917731
33regulation of dendritic cell antigen processing and presentation (GO:0002604)3.93203288
34protein homotrimerization (GO:0070207)3.86107182
35activation of Rac GTPase activity (GO:0032863)3.82291360
36prepulse inhibition (GO:0060134)3.80143883
37cellular response to cadmium ion (GO:0071276)3.70878373
38short-term memory (GO:0007614)3.59074956
39iron ion import (GO:0097286)3.58225843
40positive regulation of toll-like receptor signaling pathway (GO:0034123)3.57896301
41regulation of metalloenzyme activity (GO:0048552)3.55587536
42UDP-N-acetylglucosamine metabolic process (GO:0006047)3.54499652
43acrosome reaction (GO:0007340)3.52237549
44regulation of mast cell degranulation (GO:0043304)3.48310868
45positive regulation of interferon-beta production (GO:0032728)3.46669318
46disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.41007073
47killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.41007073
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.36480704
49regulation of antigen processing and presentation (GO:0002577)3.32746200
50chondroitin sulfate catabolic process (GO:0030207)3.24610078
51regulation of interferon-beta production (GO:0032648)3.23080038
52regulation of mast cell activation involved in immune response (GO:0033006)3.22597930
53fusion of sperm to egg plasma membrane (GO:0007342)3.22246185
54long term synaptic depression (GO:0060292)3.15104254
55cellular response to heat (GO:0034605)3.09852695
56import into cell (GO:0098657)3.07052086
57regulation of RNA export from nucleus (GO:0046831)3.03547222
58negative regulation of telomere maintenance (GO:0032205)3.02740740
59axonemal dynein complex assembly (GO:0070286)3.02568154
60lysosome organization (GO:0007040)2.97290146
61lytic vacuole organization (GO:0080171)2.97290146
62phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96658680
63positive regulation of antigen processing and presentation (GO:0002579)2.90901622
64positive regulation of chemokine production (GO:0032722)2.87692396
65binding of sperm to zona pellucida (GO:0007339)2.86373426
66antigen processing and presentation of endogenous antigen (GO:0019883)2.85535498
67negative regulation of B cell apoptotic process (GO:0002903)2.85310349
68neutrophil activation (GO:0042119)2.85059736
69positive regulation of interferon-gamma production (GO:0032729)2.84787216
70regulation of cilium movement (GO:0003352)2.83002978
71positive regulation of T cell apoptotic process (GO:0070234)2.82623895
72regulation of Cdc42 GTPase activity (GO:0043088)2.79501642
73epithelial structure maintenance (GO:0010669)2.79232502
74leukocyte mediated cytotoxicity (GO:0001909)2.77699003
75negative regulation of calcium ion transport into cytosol (GO:0010523)2.72476109
76granulocyte activation (GO:0036230)2.71973587
77dopamine transport (GO:0015872)2.69845733
78biotin metabolic process (GO:0006768)2.69318003
79retinal cone cell development (GO:0046549)2.68640893
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.67496346
81positive regulation of mast cell degranulation (GO:0043306)2.67496346
82type I interferon signaling pathway (GO:0060337)2.66629447
83cellular response to type I interferon (GO:0071357)2.66629447
84cranial suture morphogenesis (GO:0060363)2.66185721
85positive regulation of DNA recombination (GO:0045911)2.66048302
86regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.66034410
87response to type I interferon (GO:0034340)2.65335970
88positive regulation of histone deacetylation (GO:0031065)2.65139776
89positive regulation of CREB transcription factor activity (GO:0032793)2.63026299
90ether lipid metabolic process (GO:0046485)2.62545582
91myeloid cell activation involved in immune response (GO:0002275)2.61086388
92macrophage activation involved in immune response (GO:0002281)2.60149834
93short-chain fatty acid metabolic process (GO:0046459)2.59831928
94sperm-egg recognition (GO:0035036)2.59604372
95prostaglandin biosynthetic process (GO:0001516)2.55022969
96prostanoid biosynthetic process (GO:0046457)2.55022969
97regulation of B cell receptor signaling pathway (GO:0050855)2.54641639
98detection of bacterium (GO:0016045)2.54330588
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53485249
100epithelial cilium movement (GO:0003351)2.52329612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.64147933
2MYC_22102868_ChIP-Seq_BL_Human4.30986757
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.27899883
4SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.01288846
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.75405568
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.64377150
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80426917
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.71009599
9SPI1_23127762_ChIP-Seq_K562_Human2.65042742
10FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.55895989
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.46112577
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.44338726
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31798587
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22256695
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.20919624
16SPI1_23547873_ChIP-Seq_NB4_Human2.01583824
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95255985
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.82988970
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73609151
20VDR_24763502_ChIP-Seq_THP-1_Human1.72516191
21NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.70822705
22VDR_21846776_ChIP-Seq_THP-1_Human1.70377578
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60130080
24UTX_26944678_Chip-Seq_JUKART_Human1.58958573
25BCL6_27268052_Chip-Seq_Bcells_Human1.56866492
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55899428
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52991452
28SCL_19346495_ChIP-Seq_HPC-7_Human1.51857201
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49181333
30CIITA_25753668_ChIP-Seq_RAJI_Human1.47407752
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45997039
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43500825
33DROSHA_22980978_ChIP-Seq_HELA_Human1.42333602
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40534176
35MAF_26560356_Chip-Seq_TH1_Human1.40165571
36SMC4_20622854_ChIP-Seq_HELA_Human1.33633242
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.29973374
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29424912
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28649733
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.27972721
41GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27759776
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.27509004
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26359678
44GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26199448
45MYB_26560356_Chip-Seq_TH2_Human1.25626702
46TCF7_22412390_ChIP-Seq_EML_Mouse1.24597335
47LXR_22292898_ChIP-Seq_THP-1_Human1.24554994
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23972669
49P68_20966046_ChIP-Seq_HELA_Human1.22506460
50P300_27268052_Chip-Seq_Bcells_Human1.21795656
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20726717
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17900806
53MYB_26560356_Chip-Seq_TH1_Human1.17084245
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15253194
55VDR_23849224_ChIP-Seq_CD4+_Human1.13981076
56GATA3_27048872_Chip-Seq_THYMUS_Human1.12842662
57PHF8_20622854_ChIP-Seq_HELA_Human1.12401591
58SOX11_22085726_ChIP-Seq_ESNs_Mouse1.11366765
59E2F1_20622854_ChIP-Seq_HELA_Human1.10582855
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10367503
61CSB_26484114_Chip-Seq_FIBROBLAST_Human1.09696952
62CTCF_20526341_ChIP-Seq_ESCs_Human1.07141851
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06197033
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06121789
65GABP_19822575_ChIP-Seq_HepG2_Human1.05917603
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.05748312
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05609227
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05090559
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04559588
70MAF_26560356_Chip-Seq_TH2_Human1.03044390
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00958623
72TP63_22573176_ChIP-Seq_HFKS_Human0.98890254
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98876836
74NANOG_20526341_ChIP-Seq_ESCs_Human0.98656030
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.97760625
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97447734
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96055503
78GATA3_26560356_Chip-Seq_TH1_Human0.95988520
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.94388935
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.94386073
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93872696
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93715102
83CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92616732
84BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.92168984
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92108771
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90446851
87FLI1_21867929_ChIP-Seq_CD8_Mouse0.89918875
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89790464
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88117001
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.87169626
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85512496
92STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85509833
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85307825
94SPI1_20517297_ChIP-Seq_HL60_Human0.85222041
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84800454
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84451196
97BCOR_27268052_Chip-Seq_Bcells_Human0.84198755
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.84150632
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83534738
100XRN2_22483619_ChIP-Seq_HELA_Human0.82076108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.95561343
2MP0003950_abnormal_plasma_membrane4.24834722
3MP0003172_abnormal_lysosome_physiology3.74304674
4MP0009379_abnormal_foot_pigmentation3.54895601
5MP0003191_abnormal_cellular_cholesterol3.11136237
6MP0001800_abnormal_humoral_immune2.66578665
7MP0001502_abnormal_circadian_rhythm2.65186744
8MP0005174_abnormal_tail_pigmentation2.63449993
9MP0004043_abnormal_pH_regulation2.61184858
10MP0001879_abnormal_lymphatic_vessel2.44924313
11MP0008004_abnormal_stomach_pH2.44388530
12MP0005387_immune_system_phenotype2.44117461
13MP0001790_abnormal_immune_system2.44117461
14MP0009384_cardiac_valve_regurgitation2.42512674
15MP0005410_abnormal_fertilization2.25480618
16MP0005645_abnormal_hypothalamus_physiol2.16523764
17MP0003186_abnormal_redox_activity2.07671956
18MP0006292_abnormal_olfactory_placode2.04163875
19MP0003279_aneurysm2.03850904
20MP0002234_abnormal_pharynx_morphology2.00975431
21MP0003878_abnormal_ear_physiology1.96291053
22MP0005377_hearing/vestibular/ear_phenot1.96291053
23MP0004084_abnormal_cardiac_muscle1.94414550
24MP0002452_abnormal_antigen_presenting1.92488836
25MP0003787_abnormal_imprinting1.87350065
26MP0004742_abnormal_vestibular_system1.85496931
27MP0006138_congestive_heart_failure1.84569390
28MP0001986_abnormal_taste_sensitivity1.80886566
29MP0002295_abnormal_pulmonary_circulatio1.78396162
30MP0002723_abnormal_immune_serum1.75109541
31MP0003879_abnormal_hair_cell1.71939898
32MP0001299_abnormal_eye_distance/1.67370870
33MP0004147_increased_porphyrin_level1.65401952
34MP0002420_abnormal_adaptive_immunity1.63370725
35MP0001819_abnormal_immune_cell1.61207311
36MP0005584_abnormal_enzyme/coenzyme_acti1.53968268
37MP0000689_abnormal_spleen_morphology1.35961687
38MP0004142_abnormal_muscle_tone1.31862519
39MP0006276_abnormal_autonomic_nervous1.31803607
40MP0005166_decreased_susceptibility_to1.31436561
41MP0002398_abnormal_bone_marrow1.30507512
42MP0003656_abnormal_erythrocyte_physiolo1.30177961
43MP0005025_abnormal_response_to1.28630639
44MP0001835_abnormal_antigen_presentation1.28258070
45MP0002638_abnormal_pupillary_reflex1.25302528
46MP0003436_decreased_susceptibility_to1.25023961
47MP0004510_myositis1.18767304
48MP0003690_abnormal_glial_cell1.16582244
49MP0003221_abnormal_cardiomyocyte_apopto1.15816887
50MP0000015_abnormal_ear_pigmentation1.15328051
51MP0000343_altered_response_to1.12701779
52MP0006035_abnormal_mitochondrial_morpho1.12131401
53MP0005058_abnormal_lysosome_morphology1.11655351
54MP0003763_abnormal_thymus_physiology1.09585122
55MP0005671_abnormal_response_to1.02490955
56MP0000538_abnormal_urinary_bladder1.02446660
57MP0001764_abnormal_homeostasis1.00928920
58MP0000716_abnormal_immune_system1.00814205
59MP0000733_abnormal_muscle_development0.98542727
60MP0009697_abnormal_copulation0.96959737
61MP0002419_abnormal_innate_immunity0.95080554
62MP0001849_ear_inflammation0.91876641
63MP0002722_abnormal_immune_system0.90357041
64MP0003300_gastrointestinal_ulcer0.88007887
65MP0002177_abnormal_outer_ear0.85795408
66MP0001905_abnormal_dopamine_level0.83816155
67MP0001501_abnormal_sleep_pattern0.83664379
68MP0000747_muscle_weakness0.83516227
69MP0005551_abnormal_eye_electrophysiolog0.80950400
70MP0002405_respiratory_system_inflammati0.80516779
71MP0005310_abnormal_salivary_gland0.80002224
72MP0001968_abnormal_touch/_nociception0.79535549
73MP0005023_abnormal_wound_healing0.79474484
74MP0002429_abnormal_blood_cell0.79037552
75MP0002063_abnormal_learning/memory/cond0.78871914
76MP0009785_altered_susceptibility_to0.78620510
77MP0003075_altered_response_to0.76550216
78MP0003183_abnormal_peptide_metabolism0.72553834
79MP0004036_abnormal_muscle_relaxation0.71316725
80MP0001845_abnormal_inflammatory_respons0.70760532
81MP0008874_decreased_physiological_sensi0.70685252
82MP0002095_abnormal_skin_pigmentation0.66854172
83MP0009053_abnormal_anal_canal0.66007644
84MP0002067_abnormal_sensory_capabilities0.65576501
85MP0009703_decreased_birth_body0.65528729
86MP0004859_abnormal_synaptic_plasticity0.65471041
87MP0004484_altered_response_of0.64424481
88MP0002229_neurodegeneration0.62645130
89MP0003303_peritoneal_inflammation0.62610398
90MP0009745_abnormal_behavioral_response0.60386747
91MP0001188_hyperpigmentation0.59945416
92MP0002572_abnormal_emotion/affect_behav0.59315655
93MP0003828_pulmonary_edema0.58622791
94MP0005452_abnormal_adipose_tissue0.55554728
95MP0000230_abnormal_systemic_arterial0.55520559
96MP0005451_abnormal_body_composition0.54758717
97MP0001756_abnormal_urination0.54627232
98MP0001486_abnormal_startle_reflex0.52128071
99MP0008469_abnormal_protein_level0.50416352
100MP0010329_abnormal_lipoprotein_level0.50380709

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.21507054
2Cervical subluxation (HP:0003308)7.80156195
3Cellulitis (HP:0100658)5.85214695
4Recurrent pneumonia (HP:0006532)5.80965266
5Eczematoid dermatitis (HP:0000976)5.42255309
6Chronic sinusitis (HP:0011109)5.13482814
7Recurrent bronchitis (HP:0002837)5.12631616
8Broad face (HP:0000283)4.62505746
9Hyperglycinemia (HP:0002154)4.36925024
10Recurrent lower respiratory tract infections (HP:0002783)4.35587804
11Meningitis (HP:0001287)4.10613534
12Osteomyelitis (HP:0002754)4.09145160
13J-shaped sella turcica (HP:0002680)4.07198541
14Papilloma (HP:0012740)3.97296153
15Verrucae (HP:0200043)3.97296153
16Recurrent gram-negative bacterial infections (HP:0005420)3.97211538
17Obstructive sleep apnea (HP:0002870)3.73311626
18Mediastinal lymphadenopathy (HP:0100721)3.65174063
19Flared iliac wings (HP:0002869)3.62505057
20Papilledema (HP:0001085)3.48907365
21Bronchitis (HP:0012387)3.41314913
22Hypoplasia of the odontoid process (HP:0003311)3.40594818
23Chronic obstructive pulmonary disease (HP:0006510)3.32331928
24Obstructive lung disease (HP:0006536)3.32331928
25Recurrent bacterial skin infections (HP:0005406)3.11660211
26Recurrent fungal infections (HP:0002841)3.04294676
27Sepsis (HP:0100806)3.02886747
28Abnormality of macrophages (HP:0004311)2.92651388
29Deformed sella turcica (HP:0002681)2.89802943
30Renal cortical cysts (HP:0000803)2.79182709
31Abnormality of the odontoid process (HP:0003310)2.77265293
32Recurrent otitis media (HP:0000403)2.68830563
33Gastrointestinal stroma tumor (HP:0100723)2.67855301
34Limb hypertonia (HP:0002509)2.65939863
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63555805
36Abnormality of alanine metabolism (HP:0010916)2.63555805
37Hyperalaninemia (HP:0003348)2.63555805
38Dehydration (HP:0001944)2.60930489
39Recurrent abscess formation (HP:0002722)2.59174593
40Inflammation of the large intestine (HP:0002037)2.58442144
41Nephronophthisis (HP:0000090)2.57415477
42Urinary glycosaminoglycan excretion (HP:0003541)2.55446946
43Mucopolysacchariduria (HP:0008155)2.55446946
44Colitis (HP:0002583)2.46038786
45Hypoplastic labia majora (HP:0000059)2.44371770
46Progressive microcephaly (HP:0000253)2.42092347
47Sleep apnea (HP:0010535)2.41889785
48Recurrent sinusitis (HP:0011108)2.40152959
49Biconcave vertebral bodies (HP:0004586)2.39157632
50Gastrointestinal inflammation (HP:0004386)2.39077779
51Skin rash (HP:0000988)2.37752705
52Neurodegeneration (HP:0002180)2.36892100
53Abnormality of transition element cation homeostasis (HP:0011030)2.36659056
54Increased serum ferritin (HP:0003281)2.35589071
55Lymphopenia (HP:0001888)2.34125471
56Abnormality of glycine metabolism (HP:0010895)2.29666639
57Abnormality of serine family amino acid metabolism (HP:0010894)2.29666639
58Thrombocytosis (HP:0001894)2.28560811
59Restrictive lung disease (HP:0002091)2.26130144
60Abnormality of the labia majora (HP:0012881)2.24760488
61Abnormality of the sella turcica (HP:0002679)2.24679913
62Asplenia (HP:0001746)2.24269703
63Abnormality of iron homeostasis (HP:0011031)2.23664350
64Hepatosplenomegaly (HP:0001433)2.22712915
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22617327
66Abnormality of polysaccharide metabolism (HP:0011012)2.22617327
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22617327
68Cerebral palsy (HP:0100021)2.16146916
69Abnormality of the renal medulla (HP:0100957)2.11108683
70Small hand (HP:0200055)2.11028867
71Oligodactyly (HP:0012165)2.08066516
72Encephalitis (HP:0002383)2.06815019
73Hemorrhage of the eye (HP:0011885)2.06762289
74Trigonocephaly (HP:0000243)2.02757010
75Long palpebral fissure (HP:0000637)1.99358541
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.98847505
77Abnormality of the renal cortex (HP:0011035)1.96763891
78Panhypogammaglobulinemia (HP:0003139)1.96348712
79Growth hormone deficiency (HP:0000824)1.94482078
80Oligodactyly (hands) (HP:0001180)1.94142714
81Gingivitis (HP:0000230)1.93322084
82Microvesicular hepatic steatosis (HP:0001414)1.93210199
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.90722340
84Spinal canal stenosis (HP:0003416)1.89851042
85Diplopia (HP:0000651)1.84757860
86Abnormality of binocular vision (HP:0011514)1.84757860
87Labial hypoplasia (HP:0000066)1.84726804
88Renal duplication (HP:0000075)1.84594768
89Myoglobinuria (HP:0002913)1.83764969
90Neutropenia (HP:0001875)1.83207691
913-Methylglutaconic aciduria (HP:0003535)1.83165524
92Hypoplastic female external genitalia (HP:0012815)1.81171582
93Recurrent skin infections (HP:0001581)1.79302638
94Skin ulcer (HP:0200042)1.79103337
95Lymphoma (HP:0002665)1.79054969
96Severe visual impairment (HP:0001141)1.76506117
97Dysostosis multiplex (HP:0000943)1.74663089
98Recurrent viral infections (HP:0004429)1.74280813
99Abnormality of serum amino acid levels (HP:0003112)1.73043728
100Aortic regurgitation (HP:0001659)1.69647649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.05083552
2MAP3K134.44030630
3MAP3K34.35692147
4DDR23.03378264
5IRAK42.83169042
6BMPR22.66007293
7PKN12.63600331
8MAP3K62.23986031
9BLK2.13728129
10MAP2K72.05845887
11MAPK152.04638612
12MAPK131.96916842
13KDR1.94130813
14NTRK21.93811569
15TLK11.88482515
16ILK1.85226923
17TYK21.83445591
18GRK61.79722136
19KIT1.77889451
20EPHA41.76472056
21MAP3K51.75526756
22FRK1.60638342
23PIM21.58213242
24TAOK21.48485996
25NTRK11.45953714
26PRKD21.43141361
27BRAF1.39932328
28MAPK121.38278533
29MAPK111.29964378
30CDK121.27286222
31EIF2AK11.27185530
32RAF11.26138416
33MAP3K41.23383111
34PRKD11.22816716
35LYN1.13802174
36CAMK2B1.06863310
37IKBKB1.04610059
38PBK0.99050702
39FYN0.99011491
40ICK0.93032252
41CAMK2G0.92350200
42DAPK10.91725375
43JAK10.87531388
44DAPK30.85223612
45MAP4K20.84653751
46SYK0.84207672
47STK380.82297405
48ZAP700.79761364
49LCK0.78876595
50PRKCE0.78556985
51DMPK0.77715779
52STK390.77367147
53DYRK1B0.75653242
54KSR20.75503233
55TAOK10.74914064
56MAP3K90.69684947
57YES10.69418020
58TESK20.64504873
59JAK20.64392465
60BRD40.62871918
61CAMK10.62476789
62TBK10.62014688
63MST40.59577705
64RIPK40.58105474
65WNK40.58022781
66PRKCQ0.56767130
67MAPK40.56363314
68RET0.54804484
69PRKCD0.54361403
70PRKD30.53410769
71MAP3K110.53156048
72ROCK20.52962385
73PDGFRA0.51042883
74PAK10.50929585
75KSR10.49758909
76FLT30.49252305
77ZAK0.47637840
78BTK0.46327555
79EPHB20.45995361
80DYRK1A0.45183655
81MST1R0.45152302
82GRK10.42834907
83IKBKE0.42627785
84PINK10.40783352
85RPS6KA40.40270024
86MAP2K30.39892286
87CDK30.39337338
88CDK140.38725380
89CAMK2D0.38577820
90PRKCZ0.37604371
91PTK2B0.36068763
92TEC0.35629093
93ADRBK10.33842647
94CSK0.33090928
95CAMK2A0.32832957
96CDK50.29533720
97CSNK1D0.28615249
98PRKAA10.27109597
99RPS6KA20.26694376
100NTRK30.25903539

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.30624009
2Primary immunodeficiency_Homo sapiens_hsa053403.39812266
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.01330437
4Graft-versus-host disease_Homo sapiens_hsa053322.82744592
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.65229970
6Autoimmune thyroid disease_Homo sapiens_hsa053202.57792852
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38043782
8Antigen processing and presentation_Homo sapiens_hsa046122.36252538
9Allograft rejection_Homo sapiens_hsa053302.35634514
10Asthma_Homo sapiens_hsa053102.30971876
11Non-homologous end-joining_Homo sapiens_hsa034502.22275125
12Leishmaniasis_Homo sapiens_hsa051401.82916237
13Viral myocarditis_Homo sapiens_hsa054161.82812713
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74614379
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72383971
16Osteoclast differentiation_Homo sapiens_hsa043801.66577131
17Type I diabetes mellitus_Homo sapiens_hsa049401.63464544
18Base excision repair_Homo sapiens_hsa034101.58303026
19Hematopoietic cell lineage_Homo sapiens_hsa046401.57068803
20Herpes simplex infection_Homo sapiens_hsa051681.56309736
21Mineral absorption_Homo sapiens_hsa049781.55565829
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45434904
23Rheumatoid arthritis_Homo sapiens_hsa053231.36786807
24Tuberculosis_Homo sapiens_hsa051521.35597010
25Morphine addiction_Homo sapiens_hsa050321.33706208
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30379301
27Mismatch repair_Homo sapiens_hsa034301.27919512
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21069100
29Synaptic vesicle cycle_Homo sapiens_hsa047211.20172643
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17916940
31Toxoplasmosis_Homo sapiens_hsa051451.16576134
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15375665
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10184311
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10148745
35Phagosome_Homo sapiens_hsa041451.09453092
36Cocaine addiction_Homo sapiens_hsa050301.09306974
37Epstein-Barr virus infection_Homo sapiens_hsa051691.08430620
38Shigellosis_Homo sapiens_hsa051311.05907416
39Propanoate metabolism_Homo sapiens_hsa006401.03114437
40Staphylococcus aureus infection_Homo sapiens_hsa051501.02842006
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01297948
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99544192
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97459716
44Influenza A_Homo sapiens_hsa051640.94711167
45Choline metabolism in cancer_Homo sapiens_hsa052310.92361965
46Inositol phosphate metabolism_Homo sapiens_hsa005620.87824702
47Chemokine signaling pathway_Homo sapiens_hsa040620.87269008
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.85804014
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79035932
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78238870
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.77502451
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76338098
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.75212385
54Legionellosis_Homo sapiens_hsa051340.74139282
55Salmonella infection_Homo sapiens_hsa051320.73827164
56HTLV-I infection_Homo sapiens_hsa051660.73743679
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72955341
58Measles_Homo sapiens_hsa051620.72238697
59Proteasome_Homo sapiens_hsa030500.71190547
60Endocytosis_Homo sapiens_hsa041440.70610594
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.67877677
62RNA polymerase_Homo sapiens_hsa030200.65701069
63Serotonergic synapse_Homo sapiens_hsa047260.65106005
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.64762157
65TNF signaling pathway_Homo sapiens_hsa046680.61723107
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61223481
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61170850
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59825858
69Malaria_Homo sapiens_hsa051440.59807904
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58903372
71Hepatitis C_Homo sapiens_hsa051600.55066328
72Cholinergic synapse_Homo sapiens_hsa047250.54348487
73FoxO signaling pathway_Homo sapiens_hsa040680.54001665
74Nicotine addiction_Homo sapiens_hsa050330.53825988
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53776379
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53141082
77Chronic myeloid leukemia_Homo sapiens_hsa052200.52953507
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.52697692
79Hepatitis B_Homo sapiens_hsa051610.49795174
80Olfactory transduction_Homo sapiens_hsa047400.48134508
81Protein export_Homo sapiens_hsa030600.46675696
82Notch signaling pathway_Homo sapiens_hsa043300.46673270
83Viral carcinogenesis_Homo sapiens_hsa052030.45457321
84Circadian rhythm_Homo sapiens_hsa047100.41953065
85Non-small cell lung cancer_Homo sapiens_hsa052230.41738440
86Pancreatic cancer_Homo sapiens_hsa052120.39262581
87Arachidonic acid metabolism_Homo sapiens_hsa005900.38675699
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37995293
89Alcoholism_Homo sapiens_hsa050340.37776680
90Galactose metabolism_Homo sapiens_hsa000520.36014830
91Ras signaling pathway_Homo sapiens_hsa040140.35536738
92Glutamatergic synapse_Homo sapiens_hsa047240.34792984
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33152152
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33107301
95Ether lipid metabolism_Homo sapiens_hsa005650.32702783
96Pyrimidine metabolism_Homo sapiens_hsa002400.29291282
97DNA replication_Homo sapiens_hsa030300.28647033
98T cell receptor signaling pathway_Homo sapiens_hsa046600.27223069
99Colorectal cancer_Homo sapiens_hsa052100.27064965
100Homologous recombination_Homo sapiens_hsa034400.26689015

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