MYO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.96927320
2central nervous system myelination (GO:0022010)5.96927320
3myelination (GO:0042552)3.78069511
4axon ensheathment (GO:0008366)3.77544687
5ensheathment of neurons (GO:0007272)3.77544687
6fatty acid elongation (GO:0030497)3.59915415
7L-amino acid import (GO:0043092)3.57250224
8negative regulation of neurotransmitter secretion (GO:0046929)3.20726489
9photoreceptor cell differentiation (GO:0046530)3.19714921
10eye photoreceptor cell differentiation (GO:0001754)3.19714921
11myelin maintenance (GO:0043217)3.15252568
12asymmetric protein localization (GO:0008105)3.12599285
13intestinal epithelial cell development (GO:0060576)3.12264850
14bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08536217
15axonal fasciculation (GO:0007413)3.07914115
16peptidyl-tyrosine autophosphorylation (GO:0038083)3.03995607
17apical protein localization (GO:0045176)3.00483084
18negative regulation of keratinocyte proliferation (GO:0010839)3.00441387
19embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99123768
20desmosome organization (GO:0002934)2.95820586
21sensory perception of smell (GO:0007608)2.87367057
22import into cell (GO:0098657)2.86316777
23negative regulation of neurotransmitter transport (GO:0051589)2.85013622
24oligodendrocyte differentiation (GO:0048709)2.84069955
25prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.81906154
26amino acid import (GO:0043090)2.81285792
27biotin metabolic process (GO:0006768)2.75678223
28calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74959561
29cellular potassium ion homeostasis (GO:0030007)2.68117693
30intraciliary transport (GO:0042073)2.62718430
31L-phenylalanine catabolic process (GO:0006559)2.61779294
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61779294
33neuron recognition (GO:0008038)2.60798486
34ectodermal placode formation (GO:0060788)2.56085423
35peripheral nervous system axon ensheathment (GO:0032292)2.55815076
36myelination in peripheral nervous system (GO:0022011)2.55815076
37regulation of keratinocyte proliferation (GO:0010837)2.55369210
38long-chain fatty acid biosynthetic process (GO:0042759)2.55106160
39potassium ion import (GO:0010107)2.51734093
40magnesium ion transport (GO:0015693)2.51425590
41very long-chain fatty acid metabolic process (GO:0000038)2.50303811
42protein localization to synapse (GO:0035418)2.47777233
43cholesterol biosynthetic process (GO:0006695)2.47629266
44keratinocyte development (GO:0003334)2.43781133
45long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43258744
46calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.42315190
47negative regulation of protein localization to cell surface (GO:2000009)2.41576819
48creatine metabolic process (GO:0006600)2.41554161
49drug transmembrane transport (GO:0006855)2.40991814
50negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.40854216
51transmission of nerve impulse (GO:0019226)2.40754673
52potassium ion homeostasis (GO:0055075)2.39605394
53polyol transport (GO:0015791)2.37377120
54branching involved in prostate gland morphogenesis (GO:0060442)2.36839013
55epithelial cell maturation (GO:0002070)2.36015063
56nonmotile primary cilium assembly (GO:0035058)2.33340986
57epithelial cilium movement (GO:0003351)2.32294995
58response to methylmercury (GO:0051597)2.31888642
59neuronal ion channel clustering (GO:0045161)2.31887680
60response to lipoprotein particle (GO:0055094)2.31832856
61presynaptic membrane assembly (GO:0097105)2.31045648
62adhesion of symbiont to host cell (GO:0044650)2.28575934
63virion attachment to host cell (GO:0019062)2.28575934
64retinal ganglion cell axon guidance (GO:0031290)2.27050858
65presynaptic membrane organization (GO:0097090)2.26908450
66artery development (GO:0060840)2.26813870
67embryonic foregut morphogenesis (GO:0048617)2.26432474
68limb bud formation (GO:0060174)2.24046196
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23571636
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.22407506
71fatty-acyl-CoA biosynthetic process (GO:0046949)2.22265518
72dendrite morphogenesis (GO:0048813)2.20859186
73chemosensory behavior (GO:0007635)2.19548519
74Sertoli cell development (GO:0060009)2.18538607
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.18515016
76L-phenylalanine metabolic process (GO:0006558)2.18515016
77cilium movement (GO:0003341)2.18174995
78nucleotide transmembrane transport (GO:1901679)2.18135208
79vocalization behavior (GO:0071625)2.18012065
80* synapse assembly (GO:0007416)2.17412235
81cellular glucuronidation (GO:0052695)2.16508683
82nerve growth factor signaling pathway (GO:0038180)2.16286792
83cardiac right ventricle morphogenesis (GO:0003215)2.15042493
84short-chain fatty acid metabolic process (GO:0046459)2.14144834
85glucuronate metabolic process (GO:0019585)2.13749484
86uronic acid metabolic process (GO:0006063)2.13749484
87substrate-independent telencephalic tangential migration (GO:0021826)2.12685797
88substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.12685797
89positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.10864975
90long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.10584533
91ectoderm development (GO:0007398)2.09165594
92sterol biosynthetic process (GO:0016126)2.08596711
93peptide biosynthetic process (GO:0043043)2.07580590
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.07105367
95regulation of bile acid biosynthetic process (GO:0070857)2.06937376
96ephrin receptor signaling pathway (GO:0048013)2.06444455
97mammary gland alveolus development (GO:0060749)2.06010356
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.05630371
99establishment of monopolar cell polarity (GO:0061162)2.05630371
100regulation of beta-amyloid formation (GO:1902003)2.05532320
101glycerophospholipid catabolic process (GO:0046475)2.04841929
102gamma-aminobutyric acid transport (GO:0015812)2.04610443
103regulation of heart rate by cardiac conduction (GO:0086091)2.04269300
104neuron cell-cell adhesion (GO:0007158)2.04191641
105neuronal action potential propagation (GO:0019227)2.03076103
106glutathione biosynthetic process (GO:0006750)2.02978038
107synaptic vesicle maturation (GO:0016188)2.02921461
108sodium ion export (GO:0071436)2.02623092
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.02386724
110polarized epithelial cell differentiation (GO:0030859)2.01946457
111regulation of lipoprotein metabolic process (GO:0050746)2.01737166
112iron ion import (GO:0097286)2.01331301
113dendritic spine organization (GO:0097061)2.01044248
114establishment of planar polarity (GO:0001736)2.00630358
115establishment of tissue polarity (GO:0007164)2.00630358
116nonribosomal peptide biosynthetic process (GO:0019184)2.00287506
117membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.99666044
118neurotransmitter catabolic process (GO:0042135)1.98731999
1193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)1.98506101
120purine ribonucleoside bisphosphate metabolic process (GO:0034035)1.98506101
121Golgi to plasma membrane protein transport (GO:0043001)1.97785415
122regulation of cilium movement (GO:0003352)1.96884410
123neuron remodeling (GO:0016322)1.96821289
124cilium morphogenesis (GO:0060271)1.96102613
125positive regulation of neurological system process (GO:0031646)1.96088380
126glycine transport (GO:0015816)1.95619960
127response to dietary excess (GO:0002021)1.94999535
128negative regulation of JUN kinase activity (GO:0043508)1.94979654
129peptidyl-cysteine modification (GO:0018198)1.94076639
130astrocyte development (GO:0014002)1.93897747
131fatty-acyl-CoA metabolic process (GO:0035337)1.93772326
132pyrimidine nucleobase catabolic process (GO:0006208)1.93116945
133acyl-CoA biosynthetic process (GO:0071616)1.92376943
134thioester biosynthetic process (GO:0035384)1.92376943
135response to redox state (GO:0051775)1.92118540
136homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.91966994
137mating behavior (GO:0007617)1.91651589
138protein polyglutamylation (GO:0018095)1.91474779
139establishment of protein localization to Golgi (GO:0072600)1.90548464
140cerebral cortex radially oriented cell migration (GO:0021799)1.89882801
141cellular response to cholesterol (GO:0071397)1.89873475
142transepithelial transport (GO:0070633)1.89747334
143cochlea development (GO:0090102)1.89659529
144ganglion development (GO:0061548)1.89596729
145regulation of clathrin-mediated endocytosis (GO:2000369)1.89584758
146hormone catabolic process (GO:0042447)1.89456440
147dendritic spine morphogenesis (GO:0060997)1.89019626
148auditory behavior (GO:0031223)1.88991124
149regulation of axon guidance (GO:1902667)1.88756197
150regulation of cholesterol biosynthetic process (GO:0045540)1.88461404
151nephron tubule formation (GO:0072079)1.88453098
152nucleobase catabolic process (GO:0046113)1.88220019
153nucleotide transport (GO:0006862)1.87837736
154C4-dicarboxylate transport (GO:0015740)1.87717132
155somite rostral/caudal axis specification (GO:0032525)1.87380146
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.86882608
157sex differentiation (GO:0007548)1.86659169
158cerebellar granule cell differentiation (GO:0021707)1.86146768
159negative regulation of axon guidance (GO:1902668)1.86127805
160positive regulation of potassium ion transport (GO:0043268)1.86065656
161membrane repolarization during action potential (GO:0086011)1.85748617
162cilium assembly (GO:0042384)1.85608136
163glandular epithelial cell differentiation (GO:0002067)1.85213484
164adhesion of symbiont to host (GO:0044406)1.84817177
165limb development (GO:0060173)1.84773625
166appendage development (GO:0048736)1.84773625
167tight junction assembly (GO:0070830)1.84546883
168Golgi to endosome transport (GO:0006895)1.84531078
169cerebellar Purkinje cell layer development (GO:0021680)1.84243747
170cilium organization (GO:0044782)1.84128845
171protein localization to Golgi apparatus (GO:0034067)1.83119987
172glial cell proliferation (GO:0014009)1.82947202
173phenol-containing compound catabolic process (GO:0019336)1.81803101
174cell communication involved in cardiac conduction (GO:0086065)1.81528656
175zinc ion transport (GO:0006829)1.81015108
176body morphogenesis (GO:0010171)1.79685328
177ventricular cardiac muscle cell action potential (GO:0086005)1.79678608
178protein targeting to Golgi (GO:0000042)1.79045817
179regulation of axon extension involved in axon guidance (GO:0048841)1.78081515
180toxin metabolic process (GO:0009404)1.77626030
181cardiac conduction (GO:0061337)1.77568627
182negative regulation of cytosolic calcium ion concentration (GO:0051481)1.77394903
183microtubule-based transport (GO:0010970)1.77385279
184central nervous system projection neuron axonogenesis (GO:0021952)1.76160266
185* synapse organization (GO:0050808)1.76031560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67189182
2GBX2_23144817_ChIP-Seq_PC3_Human2.53668756
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44634237
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21952641
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07700246
6EZH2_22144423_ChIP-Seq_EOC_Human1.99073280
7IGF1R_20145208_ChIP-Seq_DFB_Human1.93327370
8EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92797957
9RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92797957
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90317252
11MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89632065
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86471225
13CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85948740
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.85796448
15DROSHA_22980978_ChIP-Seq_HELA_Human1.85391747
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85095820
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83389166
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81527329
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.73810433
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71496611
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70624164
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.67297146
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.63980980
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61955267
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61815277
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.61732914
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61686119
28AR_21572438_ChIP-Seq_LNCaP_Human1.61054596
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.60511265
30FUS_26573619_Chip-Seq_HEK293_Human1.51782118
31AR_21909140_ChIP-Seq_LNCAP_Human1.51435588
32ZNF274_21170338_ChIP-Seq_K562_Hela1.50949265
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.49114618
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48061023
35* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47937061
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.45904827
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.40411530
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36153979
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36087690
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35547565
41RNF2_27304074_Chip-Seq_NSC_Mouse1.35034600
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34783117
43* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34755365
44AHR_22903824_ChIP-Seq_MCF-7_Human1.34563523
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34430163
46TAF15_26573619_Chip-Seq_HEK293_Human1.33474652
47AR_25329375_ChIP-Seq_VCAP_Human1.33050383
48* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32659605
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32463982
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.29419910
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.28122984
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28033041
53EWS_26573619_Chip-Seq_HEK293_Human1.26537133
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26277299
55VDR_22108803_ChIP-Seq_LS180_Human1.24470617
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.24060551
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.23427686
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21890031
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21041781
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20583177
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20583177
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20220303
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17068353
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16285506
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.16063958
66FOXA1_25552417_ChIP-Seq_VCAP_Human1.16053165
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.15210544
68STAT3_23295773_ChIP-Seq_U87_Human1.13570259
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13287931
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13141639
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11861575
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11687939
73* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10837542
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10357285
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08555249
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07935402
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07031215
78RUNX2_22187159_ChIP-Seq_PCA_Human1.06665307
79* TCF4_22108803_ChIP-Seq_LS180_Human1.06650231
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06543329
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06311633
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.05645572
83P300_19829295_ChIP-Seq_ESCs_Human1.04918129
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04828440
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.04492617
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04176469
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04070378
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04068939
89REST_21632747_ChIP-Seq_MESCs_Mouse1.03689982
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.03394351
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03364399
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02535375
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01914781
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.01555074
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.01202703
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01194849
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.00918060
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.00685740
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.99547317
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.99185842
101TP53_18474530_ChIP-ChIP_U2OS_Human0.99105772
102TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98559981
103TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98451407
104* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98000347
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.97281411
106TP53_16413492_ChIP-PET_HCT116_Human0.96602103
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96374130
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96287328
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96086925
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96052667
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.95966467
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95434920
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.95011264
114RXR_22108803_ChIP-Seq_LS180_Human0.94818744
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94615613
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.94299645
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94284369
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93412873
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.92757914
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92596672
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91738752
122* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91641002
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91611972
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90597029
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90326401
126* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90009499
127* SOX2_20726797_ChIP-Seq_SW620_Human0.89869459
128BCAT_22108803_ChIP-Seq_LS180_Human0.89836107
129ER_23166858_ChIP-Seq_MCF-7_Human0.89823327
130TCF4_23295773_ChIP-Seq_U87_Human0.89109440
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.88223173
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86975760
133AR_19668381_ChIP-Seq_PC3_Human0.86463120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.61994884
2MP0000920_abnormal_myelination2.75757014
3MP0004885_abnormal_endolymph2.75152217
4MP0003690_abnormal_glial_cell2.68683635
5MP0001984_abnormal_olfaction2.53739453
6MP0009780_abnormal_chondrocyte_physiolo2.43864554
7MP0004270_analgesia2.41375220
8MP0003123_paternal_imprinting2.37506718
9MP0005360_urolithiasis2.31420215
10MP0003195_calcinosis2.28457632
11MP0000537_abnormal_urethra_morphology2.25857331
12MP0003787_abnormal_imprinting2.12345385
13MP0003890_abnormal_embryonic-extraembry1.99983583
14MP0003329_amyloid_beta_deposits1.97642457
15* MP0001486_abnormal_startle_reflex1.97588586
16MP0004859_abnormal_synaptic_plasticity1.85659789
17* MP0001485_abnormal_pinna_reflex1.84507160
18MP0008875_abnormal_xenobiotic_pharmacok1.83328552
19MP0002139_abnormal_hepatobiliary_system1.83108662
20MP0003878_abnormal_ear_physiology1.77945046
21MP0005377_hearing/vestibular/ear_phenot1.77945046
22MP0000462_abnormal_digestive_system1.69553825
23MP0003122_maternal_imprinting1.68117422
24MP0003252_abnormal_bile_duct1.67271746
25MP0010678_abnormal_skin_adnexa1.67207680
26MP0003121_genomic_imprinting1.62876248
27MP0003634_abnormal_glial_cell1.59067745
28MP0010234_abnormal_vibrissa_follicle1.58829114
29MP0003880_abnormal_central_pattern1.52365399
30MP0003136_yellow_coat_color1.50554658
31* MP0002272_abnormal_nervous_system1.50345212
32MP0003950_abnormal_plasma_membrane1.48145026
33MP0000778_abnormal_nervous_system1.43223218
34MP0002064_seizures1.41763086
35MP0005187_abnormal_penis_morphology1.41640177
36MP0003635_abnormal_synaptic_transmissio1.41059365
37MP0004133_heterotaxia1.41038799
38MP0005085_abnormal_gallbladder_physiolo1.37811452
39MP0001666_abnormal_nutrient_absorption1.36634518
40MP0005332_abnormal_amino_acid1.36574034
41MP0005365_abnormal_bile_salt1.34860449
42MP0005646_abnormal_pituitary_gland1.34679390
43MP0002734_abnormal_mechanical_nocicepti1.29316672
44MP0005171_absent_coat_pigmentation1.29312473
45MP0001765_abnormal_ion_homeostasis1.28304638
46MP0003941_abnormal_skin_development1.27849601
47* MP0005551_abnormal_eye_electrophysiolog1.27310310
48* MP0004742_abnormal_vestibular_system1.27242243
49MP0004019_abnormal_vitamin_homeostasis1.26339418
50MP0009745_abnormal_behavioral_response1.24029956
51* MP0002229_neurodegeneration1.23591807
52MP0005367_renal/urinary_system_phenotyp1.22260741
53MP0000516_abnormal_urinary_system1.22260741
54MP0002822_catalepsy1.21951969
55MP0003315_abnormal_perineum_morphology1.21760750
56MP0002234_abnormal_pharynx_morphology1.21651949
57MP0000566_synostosis1.19180212
58MP0000383_abnormal_hair_follicle1.17853921
59MP0003937_abnormal_limbs/digits/tail_de1.17304120
60MP0003283_abnormal_digestive_organ1.16352211
61* MP0001963_abnormal_hearing_physiology1.15500965
62MP0003633_abnormal_nervous_system1.14616863
63MP0003755_abnormal_palate_morphology1.13168074
64MP0002938_white_spotting1.13137879
65MP0003942_abnormal_urinary_system1.13026375
66MP0010030_abnormal_orbit_morphology1.12641841
67MP0001299_abnormal_eye_distance/1.12247412
68MP0003632_abnormal_nervous_system1.11598283
69MP0005645_abnormal_hypothalamus_physiol1.11517865
70MP0002184_abnormal_innervation1.11498615
71MP0006276_abnormal_autonomic_nervous1.09746566
72MP0009384_cardiac_valve_regurgitation1.09165868
73MP0000534_abnormal_ureter_morphology1.08945533
74MP0000631_abnormal_neuroendocrine_gland1.08061717
75MP0003011_delayed_dark_adaptation1.07432610
76MP0002233_abnormal_nose_morphology1.07271000
77MP0002063_abnormal_learning/memory/cond1.06731631
78MP0001177_atelectasis1.06335194
79MP0001346_abnormal_lacrimal_gland1.05922678
80MP0002876_abnormal_thyroid_physiology1.05792149
81MP0000427_abnormal_hair_cycle1.04592615
82MP0009046_muscle_twitch1.03927750
83MP0005409_darkened_coat_color1.03571455
84MP0005248_abnormal_Harderian_gland1.03431820
85MP0005423_abnormal_somatic_nervous1.02125361
86MP0000538_abnormal_urinary_bladder1.01867577
87MP0003631_nervous_system_phenotype1.01279933
88MP0002572_abnormal_emotion/affect_behav0.99844058
89MP0009643_abnormal_urine_homeostasis0.99740844
90MP0004858_abnormal_nervous_system0.99376322
91MP0004782_abnormal_surfactant_physiolog0.99143799
92MP0000467_abnormal_esophagus_morphology0.98870358
93MP0008789_abnormal_olfactory_epithelium0.98113211
94MP0005499_abnormal_olfactory_system0.98066504
95MP0005394_taste/olfaction_phenotype0.98066504
96MP0002796_impaired_skin_barrier0.97886849
97MP0000013_abnormal_adipose_tissue0.97517871
98* MP0002882_abnormal_neuron_morphology0.97281765
99MP0003861_abnormal_nervous_system0.96758697
100MP0005167_abnormal_blood-brain_barrier0.94484599
101MP0001502_abnormal_circadian_rhythm0.93923258
102MP0002090_abnormal_vision0.93369332
103MP0003119_abnormal_digestive_system0.93171107
104MP0000762_abnormal_tongue_morphology0.92382169
105* MP0000026_abnormal_inner_ear0.92289957
106MP0005386_behavior/neurological_phenoty0.92083914
107MP0004924_abnormal_behavior0.92083914
108MP0008569_lethality_at_weaning0.92014348
109MP0004272_abnormal_basement_membrane0.91354507
110MP0001664_abnormal_digestion0.91262913
111MP0002118_abnormal_lipid_homeostasis0.90959050
112MP0001501_abnormal_sleep_pattern0.90918959
113MP0001440_abnormal_grooming_behavior0.90538318
114MP0000955_abnormal_spinal_cord0.89763451
115MP0002557_abnormal_social/conspecific_i0.89559197
116MP0003806_abnormal_nucleotide_metabolis0.89153697
117MP0004147_increased_porphyrin_level0.88464356
118MP0002098_abnormal_vibrissa_morphology0.88373242
119MP0003300_gastrointestinal_ulcer0.88059012
120MP0010368_abnormal_lymphatic_system0.86529921
121MP0001529_abnormal_vocalization0.86034785
122MP0000377_abnormal_hair_follicle0.85263848
123MP0002152_abnormal_brain_morphology0.84621345
124MP0000579_abnormal_nail_morphology0.83854537
125MP0002295_abnormal_pulmonary_circulatio0.83790238
126MP0008877_abnormal_DNA_methylation0.83741544
127MP0000003_abnormal_adipose_tissue0.83609362
128MP0002896_abnormal_bone_mineralization0.82346072
129MP0002697_abnormal_eye_size0.81865381
130MP0002160_abnormal_reproductive_system0.81738382
131MP0000647_abnormal_sebaceous_gland0.81172493
132MP0000604_amyloidosis0.81042467
133* MP0002752_abnormal_somatic_nervous0.80889304
134MP0003879_abnormal_hair_cell0.80880158
135* MP0002067_abnormal_sensory_capabilities0.78726089
136MP0001905_abnormal_dopamine_level0.78424413
137MP0006072_abnormal_retinal_apoptosis0.78129541
138MP0002653_abnormal_ependyma_morphology0.77382810
139MP0004134_abnormal_chest_morphology0.76503406
140* MP0002066_abnormal_motor_capabilities/c0.76469425
141MP0001944_abnormal_pancreas_morphology0.75894622
142MP0003936_abnormal_reproductive_system0.75792961
143MP0003935_abnormal_craniofacial_develop0.75589617
144MP0005253_abnormal_eye_physiology0.75368271
145MP0005195_abnormal_posterior_eye0.74473862
146MP0004264_abnormal_extraembryonic_tissu0.73534286
147MP0002909_abnormal_adrenal_gland0.73107498
148MP0002116_abnormal_craniofacial_bone0.72113809
149MP0000613_abnormal_salivary_gland0.71381859
150MP0001879_abnormal_lymphatic_vessel0.71279146
151MP0005220_abnormal_exocrine_pancreas0.71008002
152MP0002735_abnormal_chemical_nociception0.69471799
153MP0002069_abnormal_eating/drinking_beha0.68904888
154MP0002736_abnormal_nociception_after0.68684950

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)4.68243225
2Increased circulating renin level (HP:0000848)4.61849005
3Neurofibrillary tangles (HP:0002185)4.25084586
4Hypokalemic alkalosis (HP:0001949)4.10753868
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.93104274
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.93104274
7Hypomagnesemia (HP:0002917)3.60347195
8Aplasia involving bones of the extremities (HP:0009825)3.19986673
9Aplasia involving bones of the upper limbs (HP:0009823)3.19986673
10Aplasia of the phalanges of the hand (HP:0009802)3.19986673
11Cerebral inclusion bodies (HP:0100314)3.08423097
12Abnormality of renin-angiotensin system (HP:0000847)3.00203768
13Abnormality of the corticospinal tract (HP:0002492)2.97575158
14Abnormality of magnesium homeostasis (HP:0004921)2.91566992
15Hyperactive renin-angiotensin system (HP:0000841)2.90966790
16Intention tremor (HP:0002080)2.89978318
17Abnormality of chloride homeostasis (HP:0011422)2.87431074
18Hyperaldosteronism (HP:0000859)2.78748192
19Right ventricular cardiomyopathy (HP:0011663)2.66672820
20Abnormal urine output (HP:0012590)2.62769439
21Polyuria (HP:0000103)2.62348049
22Polydipsia (HP:0001959)2.61133734
23Abnormal drinking behavior (HP:0030082)2.61133734
24Onion bulb formation (HP:0003383)2.59496789
25Abnormal auditory evoked potentials (HP:0006958)2.53781159
26Abnormality of renal excretion (HP:0011036)2.52859987
27Intrahepatic cholestasis (HP:0001406)2.50929612
28Alkalosis (HP:0001948)2.50050709
29Peripheral hypomyelination (HP:0007182)2.49018845
30Humeroradial synostosis (HP:0003041)2.45742846
31Synostosis involving the elbow (HP:0003938)2.45742846
32Gait imbalance (HP:0002141)2.44702126
33Hypokalemia (HP:0002900)2.43587218
34Medial flaring of the eyebrow (HP:0010747)2.42196542
35Abnormal pancreas size (HP:0012094)2.41179317
36Hypoglycemic seizures (HP:0002173)2.39397707
37Megalencephaly (HP:0001355)2.39248851
38Retinal dysplasia (HP:0007973)2.38388389
39Hyperinsulinemic hypoglycemia (HP:0000825)2.36913989
40Hepatoblastoma (HP:0002884)2.34003940
41Renal salt wasting (HP:0000127)2.34000605
42Sensory axonal neuropathy (HP:0003390)2.32686935
43Abnormality of the middle phalanges of the toes (HP:0010183)2.32128581
44Spastic gait (HP:0002064)2.32032962
45Congenital primary aphakia (HP:0007707)2.31715152
46Supranuclear gaze palsy (HP:0000605)2.31496662
47Pancreatic fibrosis (HP:0100732)2.30298884
48Confusion (HP:0001289)2.28440187
49True hermaphroditism (HP:0010459)2.27267899
50Abnormality of potassium homeostasis (HP:0011042)2.26615224
51Nephronophthisis (HP:0000090)2.22511215
52Termporal pattern (HP:0011008)2.22505855
53Insidious onset (HP:0003587)2.22505855
54Facial shape deformation (HP:0011334)2.21858034
55Potter facies (HP:0002009)2.21858034
56Symptomatic seizures (HP:0011145)2.20570928
57Abnormality of midbrain morphology (HP:0002418)2.20560262
58Molar tooth sign on MRI (HP:0002419)2.20560262
59Ketoacidosis (HP:0001993)2.19252550
60Dysmetria (HP:0001310)2.18564464
61Genital tract atresia (HP:0001827)2.18050415
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17079275
63Myokymia (HP:0002411)2.17060540
64Chronic hepatic failure (HP:0100626)2.16489861
65Alacrima (HP:0000522)2.16265080
66Vaginal atresia (HP:0000148)2.14384814
67Abnormality of the renal medulla (HP:0100957)2.12152531
68Action tremor (HP:0002345)2.10926410
69Pancreatic cysts (HP:0001737)2.09440161
70Nephrogenic diabetes insipidus (HP:0009806)2.09374865
71Parakeratosis (HP:0001036)2.06901677
72Proximal tubulopathy (HP:0000114)2.05895642
73Abnormality of serine family amino acid metabolism (HP:0010894)2.05606164
74Abnormality of glycine metabolism (HP:0010895)2.05606164
75Thickened helices (HP:0000391)2.05442177
76Focal segmental glomerulosclerosis (HP:0000097)2.04616635
77Hypoplasia of the iris (HP:0007676)2.04520524
78Conjugated hyperbilirubinemia (HP:0002908)2.03079459
79Scanning speech (HP:0002168)1.98301975
80Split foot (HP:0001839)1.98178653
81Abnormality of the renal cortex (HP:0011035)1.96703188
82Tubular atrophy (HP:0000092)1.95662999
83Anteriorly placed anus (HP:0001545)1.95643714
84Labial hypoplasia (HP:0000066)1.95426865
85Rickets (HP:0002748)1.94536904
86Poor coordination (HP:0002370)1.94146795
87Congenital sensorineural hearing impairment (HP:0008527)1.93640071
88Clumsiness (HP:0002312)1.92897939
89Hypophosphatemic rickets (HP:0004912)1.92305591
90Hypoplastic labia majora (HP:0000059)1.92092385
91Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91634640
92Hypoglycemic coma (HP:0001325)1.91562267
93Glomerulosclerosis (HP:0000096)1.90375110
94Coronal craniosynostosis (HP:0004440)1.90168849
95Cystic liver disease (HP:0006706)1.90031150
96Absent eyebrow (HP:0002223)1.88900080
97Gout (HP:0001997)1.88319669
98Vascular calcification (HP:0004934)1.87741693
99Ileus (HP:0002595)1.87518863
100Abnormality of the labia minora (HP:0012880)1.85531415
101Ankle clonus (HP:0011448)1.85110082
102Tetany (HP:0001281)1.84871859
103Mixed hearing impairment (HP:0000410)1.84766027
104Lip pit (HP:0100267)1.83382240
105Tubulointerstitial nephritis (HP:0001970)1.83312455
106Curly hair (HP:0002212)1.82828519
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81245107
108Hyperglycinuria (HP:0003108)1.80797301
109Abnormality of permanent molar morphology (HP:0011071)1.79986009
110Abnormality of the dental root (HP:0006486)1.79986009
111Taurodontia (HP:0000679)1.79986009
112Shawl scrotum (HP:0000049)1.79532178
113Gonadotropin excess (HP:0000837)1.79111487
114Abnormality of calcium-phosphate metabolism (HP:0100530)1.77682262
115Bifid scrotum (HP:0000048)1.76294254
116Ketosis (HP:0001946)1.74690594
117Xanthomatosis (HP:0000991)1.74093128
118Protuberant abdomen (HP:0001538)1.72135543
119Enlarged kidneys (HP:0000105)1.71775619
120Bronchomalacia (HP:0002780)1.71451029
121Occipital encephalocele (HP:0002085)1.71209925
122Hyperglycinemia (HP:0002154)1.70627987
123Concave nail (HP:0001598)1.70196836
124Turricephaly (HP:0000262)1.69243188
125Hyperkalemia (HP:0002153)1.68777962
126Hypoplastic female external genitalia (HP:0012815)1.68139732
127Germ cell neoplasia (HP:0100728)1.66450944
128Postaxial hand polydactyly (HP:0001162)1.66375948
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.66231984
130Pheochromocytoma (HP:0002666)1.66152235
131Cupped ear (HP:0000378)1.65889241
132Abnormality of molar (HP:0011077)1.65688814
133Abnormality of molar morphology (HP:0011070)1.65688814
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.64588469
135Absent hair (HP:0002298)1.64490052
136Abnormality of the labia majora (HP:0012881)1.64371229
137Renal hypoplasia (HP:0000089)1.64291299
138Abnormal tarsal ossification (HP:0008369)1.63862612
139Septate vagina (HP:0001153)1.63543175
140Laryngomalacia (HP:0001601)1.63510766
141Large for gestational age (HP:0001520)1.63290618
142Cardiovascular calcification (HP:0011915)1.62767884
143Lower limb muscle weakness (HP:0007340)1.61698274
144Decreased lacrimation (HP:0000633)1.61358022
145Hyperventilation (HP:0002883)1.60177616
146Morphological abnormality of the inner ear (HP:0011390)1.59986440
147Abnormality of the axillary hair (HP:0100134)1.59014047
148Abnormality of secondary sexual hair (HP:0009888)1.59014047
149Segmental peripheral demyelination/remyelination (HP:0003481)1.58590201
150Bifid tongue (HP:0010297)1.58306415
151Drooling (HP:0002307)1.58050714
152Abolished electroretinogram (ERG) (HP:0000550)1.57741379
153Renal cortical cysts (HP:0000803)1.57151761
154Woolly hair (HP:0002224)1.56376195
155Abnormality of the dental pulp (HP:0006479)1.56161937
156Micropenis (HP:0000054)1.55968251
157Blue irides (HP:0000635)1.55912274
158Macroorchidism (HP:0000053)1.54487748
159Adrenal hypoplasia (HP:0000835)1.52510508
160Focal seizures (HP:0007359)1.51125641
161Male pseudohermaphroditism (HP:0000037)1.50466522
162Abnormality of the labia (HP:0000058)1.49408756
163Broad nasal tip (HP:0000455)1.48625686
164Postaxial foot polydactyly (HP:0001830)1.46511718
165Volvulus (HP:0002580)1.45845716
166Scrotal hypoplasia (HP:0000046)1.45590030
167EEG with generalized epileptiform discharges (HP:0011198)1.45534124
168Epileptiform EEG discharges (HP:0011182)1.45382463
169Decreased circulating renin level (HP:0003351)1.44613617
170Limb dystonia (HP:0002451)1.44565009
171Congenital malformation of the right heart (HP:0011723)1.44062018
172Double outlet right ventricle (HP:0001719)1.44062018
173Specific learning disability (HP:0001328)1.44058981
174Preaxial hand polydactyly (HP:0001177)1.43777249
175Amelogenesis imperfecta (HP:0000705)1.43515577
176Anal stenosis (HP:0002025)1.42953953
177Hypsarrhythmia (HP:0002521)1.42946694
178Tachypnea (HP:0002789)1.42328814
179Chronic bronchitis (HP:0004469)1.41664344
180Gaze-evoked nystagmus (HP:0000640)1.41640383
181Renal dysplasia (HP:0000110)1.41427337
182Short tibia (HP:0005736)1.41358179
183Absent eyelashes (HP:0000561)1.41174117
184Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.40997094
185Abnormality of the nasal septum (HP:0000419)1.40170688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.20973798
2OXSR14.37123656
3WNK43.40978820
4EPHA22.71596911
5EPHB12.61312646
6INSRR2.27869301
7MAPK152.10012066
8MAP3K22.03746192
9TNIK1.93284639
10MET1.92574175
11WNK11.88514708
12MST41.82555696
13EPHA41.82374431
14CAMK1D1.81579749
15WNK31.67146387
16FGFR21.65873469
17NTRK11.65785149
18STK38L1.65377655
19TRIM281.64798908
20SGK2231.61349312
21SGK4941.61349312
22PKN11.60970289
23NEK61.56566995
24PRKD31.52981397
25BCR1.52239451
26EPHB21.48578129
27FRK1.39264933
28LMTK21.38226526
29MAPK131.35345131
30MAP3K91.31044774
31CAMK2B1.27920040
32ICK1.26955608
33MINK11.25878833
34PHKG21.25331284
35PHKG11.25331284
36CSNK1A1L1.23565479
37TAF11.18842686
38MAPKAPK51.16721563
39MAP3K41.15559715
40PAK61.15332300
41CAMK2D1.13159874
42TYRO31.12553914
43BMPR1B1.11199162
44STK241.08994790
45ERBB31.08191215
46UHMK11.06912592
47FER1.02204730
48BRSK21.02147406
49HIPK20.99237530
50CASK0.97489496
51LATS10.96625675
52PKN20.96211494
53DDR20.95397947
54MAP3K120.95137849
55PRKCI0.95132017
56MAP2K20.94281087
57CAMK2G0.92622970
58ROCK20.92182585
59PRPF4B0.90920746
60CSNK1G10.90417133
61ERBB40.89798826
62PBK0.89665801
63CSNK1G20.88449570
64EPHA30.87146547
65NTRK30.85443245
66CDK50.85031609
67MAP4K20.84654591
68NUAK10.84513624
69CSNK1G30.84174743
70NTRK20.84070281
71PRKCE0.83430693
72TNK20.82509706
73IRAK20.81190623
74AKT30.81160588
75SIK10.80227046
76MARK20.80075607
77MST1R0.78775152
78PDPK10.78221029
79STK30.77725511
80PRKD10.77517680
81PRKCG0.75701024
82CAMK1G0.74381164
83MAP2K70.73658692
84PRKCH0.72229953
85CAMK2A0.71170654
86LATS20.70742652
87FGR0.70277619
88MARK10.67121730
89IRAK10.66539194
90STK160.64858432
91CSNK1E0.64747874
92PRKCQ0.64305230
93TIE10.64254475
94ACVR1B0.63482111
95SGK30.62231841
96MAP3K70.62153772
97PTK20.60914520
98GSK3A0.60680277
99CDK190.59316315
100PRKD20.59031962
101SGK20.58279755
102PLK20.56634764
103ERBB20.56448243
104PNCK0.56257731
105PRKAA10.55771046
106KSR20.55179517
107SIK30.55083804
108SGK10.55024863
109ROCK10.53881745
110BMX0.53664449
111PRKCZ0.53512825
112PTK60.52971388
113DAPK20.52413861
114FGFR10.52175783
115STK110.51803625
116PIK3CA0.51570914
117PINK10.51161830
118KSR10.50987291
119PDGFRB0.48815437
120DYRK1A0.48239500
121TRPM70.47836283
122WEE10.47789241
123MKNK20.47703369
124MAP3K10.47085352
125PRKAA20.47083193
126FYN0.46904957
127GRK10.46579941
128CSNK1A10.46122455
129DYRK20.44997920
130RIPK10.44758788
131DMPK0.44073258
132DYRK1B0.43300130
133STK380.41748077
134LIMK10.41515883
135* PAK30.40313515
136PRKG10.39681411
137CLK10.39464364
138BRD40.38263592
139ILK0.37688775
140CHUK0.37317780
141RPS6KB10.33484492
142MTOR0.33266737
143EEF2K0.33193137

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.52510661
2Sulfur metabolism_Homo sapiens_hsa009202.62297831
3Steroid biosynthesis_Homo sapiens_hsa001002.29672876
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15868281
5Butanoate metabolism_Homo sapiens_hsa006501.98861660
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97258941
7Fatty acid elongation_Homo sapiens_hsa000621.89985693
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.79797733
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74668995
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70755097
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58619046
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58403831
13Bile secretion_Homo sapiens_hsa049761.53917747
14Histidine metabolism_Homo sapiens_hsa003401.50713441
15Protein export_Homo sapiens_hsa030601.49655797
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44729111
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42105285
18Mineral absorption_Homo sapiens_hsa049781.38947849
19Olfactory transduction_Homo sapiens_hsa047401.36864634
20Gastric acid secretion_Homo sapiens_hsa049711.26985356
21Ether lipid metabolism_Homo sapiens_hsa005651.25895546
22Fatty acid metabolism_Homo sapiens_hsa012121.23289270
23GABAergic synapse_Homo sapiens_hsa047271.20696787
24Insulin secretion_Homo sapiens_hsa049111.18246589
25Phenylalanine metabolism_Homo sapiens_hsa003601.17080854
26Fatty acid degradation_Homo sapiens_hsa000711.16836953
27Hippo signaling pathway_Homo sapiens_hsa043901.15355623
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12799868
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12513626
30Sphingolipid metabolism_Homo sapiens_hsa006001.11845026
31Vitamin digestion and absorption_Homo sapiens_hsa049771.10828659
32Glutamatergic synapse_Homo sapiens_hsa047241.09516479
33Propanoate metabolism_Homo sapiens_hsa006401.08664782
34Caffeine metabolism_Homo sapiens_hsa002321.08394110
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.08281331
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.07120758
37Salivary secretion_Homo sapiens_hsa049701.06142592
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03115791
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01741237
40Circadian rhythm_Homo sapiens_hsa047101.00181400
41Fatty acid biosynthesis_Homo sapiens_hsa000610.99852133
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97511151
43ABC transporters_Homo sapiens_hsa020100.97020696
44Axon guidance_Homo sapiens_hsa043600.97012356
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96417988
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.95754718
47Peroxisome_Homo sapiens_hsa041460.94876588
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94661940
49Hedgehog signaling pathway_Homo sapiens_hsa043400.94498599
50Tryptophan metabolism_Homo sapiens_hsa003800.94321690
51Selenocompound metabolism_Homo sapiens_hsa004500.93921413
52Pancreatic secretion_Homo sapiens_hsa049720.92416495
53Chemical carcinogenesis_Homo sapiens_hsa052040.90701299
54Lysine degradation_Homo sapiens_hsa003100.90341789
55PPAR signaling pathway_Homo sapiens_hsa033200.90192259
56Arginine and proline metabolism_Homo sapiens_hsa003300.90188871
57Circadian entrainment_Homo sapiens_hsa047130.90180648
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89640770
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88590526
60Arginine biosynthesis_Homo sapiens_hsa002200.87456528
61Morphine addiction_Homo sapiens_hsa050320.87051734
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86997571
63Thyroid hormone synthesis_Homo sapiens_hsa049180.86883409
64Cocaine addiction_Homo sapiens_hsa050300.83527357
65Adherens junction_Homo sapiens_hsa045200.82894848
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82415301
67Retinol metabolism_Homo sapiens_hsa008300.82124600
68Tight junction_Homo sapiens_hsa045300.81648437
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81592695
70Basal transcription factors_Homo sapiens_hsa030220.81294336
71Basal cell carcinoma_Homo sapiens_hsa052170.80628829
72beta-Alanine metabolism_Homo sapiens_hsa004100.79495701
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79426138
74Dorso-ventral axis formation_Homo sapiens_hsa043200.77714974
75Protein digestion and absorption_Homo sapiens_hsa049740.77241200
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75091398
77Starch and sucrose metabolism_Homo sapiens_hsa005000.74075757
78Fat digestion and absorption_Homo sapiens_hsa049750.73990211
79Ovarian steroidogenesis_Homo sapiens_hsa049130.72401780
80Pyruvate metabolism_Homo sapiens_hsa006200.71417844
81Renin secretion_Homo sapiens_hsa049240.71414585
82Serotonergic synapse_Homo sapiens_hsa047260.70229993
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70170783
84Taste transduction_Homo sapiens_hsa047420.68811892
85Linoleic acid metabolism_Homo sapiens_hsa005910.66877131
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66689485
87Vibrio cholerae infection_Homo sapiens_hsa051100.66577454
88Cholinergic synapse_Homo sapiens_hsa047250.66226882
89AMPK signaling pathway_Homo sapiens_hsa041520.63241149
90Phototransduction_Homo sapiens_hsa047440.63006822
91cAMP signaling pathway_Homo sapiens_hsa040240.62772616
92Amphetamine addiction_Homo sapiens_hsa050310.62708408
93Glucagon signaling pathway_Homo sapiens_hsa049220.62627835
94Glycerolipid metabolism_Homo sapiens_hsa005610.61847547
95Glutathione metabolism_Homo sapiens_hsa004800.61683020
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.60690963
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59516209
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58303891
99Tyrosine metabolism_Homo sapiens_hsa003500.56767023
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56680457
101Dopaminergic synapse_Homo sapiens_hsa047280.55970742
102Type II diabetes mellitus_Homo sapiens_hsa049300.55918293
103Nicotine addiction_Homo sapiens_hsa050330.54787680
104Long-term depression_Homo sapiens_hsa047300.54002677
105Renin-angiotensin system_Homo sapiens_hsa046140.53407121
106Wnt signaling pathway_Homo sapiens_hsa043100.52934204
107Vitamin B6 metabolism_Homo sapiens_hsa007500.52216250
108TGF-beta signaling pathway_Homo sapiens_hsa043500.51678925
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.51168301
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50229787
111Gap junction_Homo sapiens_hsa045400.49879932
112Folate biosynthesis_Homo sapiens_hsa007900.48866146
113Melanogenesis_Homo sapiens_hsa049160.47593930
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.47139752
115Collecting duct acid secretion_Homo sapiens_hsa049660.46705340
116Synaptic vesicle cycle_Homo sapiens_hsa047210.46148945
117Notch signaling pathway_Homo sapiens_hsa043300.45858808
118Long-term potentiation_Homo sapiens_hsa047200.45462454
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44782266
120ECM-receptor interaction_Homo sapiens_hsa045120.44585170
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44114547
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41979699
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41554520
124Choline metabolism in cancer_Homo sapiens_hsa052310.41410217

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