MYO9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.53726623
2neuron cell-cell adhesion (GO:0007158)4.37195714
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.29686703
4vocalization behavior (GO:0071625)4.13567190
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.10599152
6synaptic vesicle maturation (GO:0016188)4.08555714
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98470753
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96822345
9protein localization to synapse (GO:0035418)3.93794322
10locomotory exploration behavior (GO:0035641)3.87731277
11glutamate receptor signaling pathway (GO:0007215)3.86921804
12establishment of protein localization to Golgi (GO:0072600)3.86859651
13interkinetic nuclear migration (GO:0022027)3.83528872
14glutamate secretion (GO:0014047)3.74780875
15dendritic spine morphogenesis (GO:0060997)3.70183618
16synaptic vesicle exocytosis (GO:0016079)3.69321042
17neuron recognition (GO:0008038)3.68172439
18regulation of synaptic vesicle exocytosis (GO:2000300)3.66088904
19presynaptic membrane assembly (GO:0097105)3.60505361
20regulation of glutamate receptor signaling pathway (GO:1900449)3.58240407
21axonal fasciculation (GO:0007413)3.58167882
22synaptic transmission, glutamatergic (GO:0035249)3.52971147
23neuron-neuron synaptic transmission (GO:0007270)3.48201920
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48061191
25layer formation in cerebral cortex (GO:0021819)3.42987192
26retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41841191
27exploration behavior (GO:0035640)3.37422309
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34885052
29proline transport (GO:0015824)3.34517316
30presynaptic membrane organization (GO:0097090)3.34461162
31neuronal action potential propagation (GO:0019227)3.33343177
32cerebellar Purkinje cell differentiation (GO:0021702)3.26948837
33nucleus localization (GO:0051647)3.26567691
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25953391
35regulation of dendritic spine morphogenesis (GO:0061001)3.23309836
36regulation of neuronal synaptic plasticity (GO:0048168)3.20606146
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.17280235
38regulation of synaptic vesicle transport (GO:1902803)3.12143120
39pericardium development (GO:0060039)3.10752227
40neurotransmitter secretion (GO:0007269)3.09279961
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09266812
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05040494
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04497771
44transmission of nerve impulse (GO:0019226)3.00588989
45gamma-aminobutyric acid signaling pathway (GO:0007214)2.99349517
46regulation of postsynaptic membrane potential (GO:0060078)2.99070759
47regulation of synapse structural plasticity (GO:0051823)2.95667389
48cell migration in hindbrain (GO:0021535)2.93651016
49dendrite morphogenesis (GO:0048813)2.93400822
50regulation of establishment of cell polarity (GO:2000114)2.90912939
51central nervous system projection neuron axonogenesis (GO:0021952)2.90271108
52cilium or flagellum-dependent cell motility (GO:0001539)2.89623876
53negative regulation of neurotransmitter transport (GO:0051589)2.89012445
54establishment of nucleus localization (GO:0040023)2.88707134
55negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88701818
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88059433
57regulation of pigment cell differentiation (GO:0050932)2.86502162
58cerebellar granule cell differentiation (GO:0021707)2.86365322
59innervation (GO:0060384)2.84586452
60regulation of synaptic transmission, glutamatergic (GO:0051966)2.84456924
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83393736
62vesicle transport along microtubule (GO:0047496)2.80871987
63membrane depolarization during action potential (GO:0086010)2.79993493
64long-term synaptic potentiation (GO:0060291)2.79875861
65piRNA metabolic process (GO:0034587)2.79385418
66lipid translocation (GO:0034204)2.79258369
67phospholipid translocation (GO:0045332)2.79258369
68behavioral defense response (GO:0002209)2.78731407
69behavioral fear response (GO:0001662)2.78731407
70regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78434184
71cytoplasmic mRNA processing body assembly (GO:0033962)2.78011216
72synaptic vesicle endocytosis (GO:0048488)2.77915310
73regulation of dendritic spine development (GO:0060998)2.77826328
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77733210
75postsynaptic membrane organization (GO:0001941)2.76234784
76long-term memory (GO:0007616)2.75524164
77protein K11-linked deubiquitination (GO:0035871)2.74633361
78positive regulation of cardiac muscle cell differentiation (GO:2000727)2.74585966
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73195139
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72407726
81synapse assembly (GO:0007416)2.72164032
82monoubiquitinated protein deubiquitination (GO:0035520)2.71186112
83response to histamine (GO:0034776)2.69887604
84phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69604638
85neurotransmitter transport (GO:0006836)2.69347916
86relaxation of cardiac muscle (GO:0055119)2.69221230
87otic vesicle formation (GO:0030916)2.68831686
88positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.68489293
89startle response (GO:0001964)2.67775775
90neurotransmitter-gated ion channel clustering (GO:0072578)2.67701149
91regulation of synaptic plasticity (GO:0048167)2.66714596
92regulation of neurotransmitter secretion (GO:0046928)2.66419360
93fear response (GO:0042596)2.66201454
94regulation of establishment or maintenance of cell polarity (GO:0032878)2.65908583
95membrane depolarization (GO:0051899)2.65362220
96Golgi to endosome transport (GO:0006895)2.64856226
97gamma-aminobutyric acid transport (GO:0015812)2.64782531
98genitalia morphogenesis (GO:0035112)2.64682941
99positive regulation of synapse maturation (GO:0090129)2.64633018
100dendritic spine organization (GO:0097061)2.61688297
101organelle transport along microtubule (GO:0072384)2.61312961
102synapse organization (GO:0050808)2.61010737
103positive regulation of membrane potential (GO:0045838)2.60809205
104neuromuscular process controlling balance (GO:0050885)2.60537880
105positive regulation of cardiac muscle hypertrophy (GO:0010613)2.60305899
106positive regulation of muscle hypertrophy (GO:0014742)2.60305899
107dendrite development (GO:0016358)2.58836183
108auditory behavior (GO:0031223)2.58229983
109learning (GO:0007612)2.56801997
110cellular potassium ion homeostasis (GO:0030007)2.56333558
111membrane hyperpolarization (GO:0060081)2.56299763
112nerve growth factor signaling pathway (GO:0038180)2.55198782
113response to auditory stimulus (GO:0010996)2.54268769
114protein targeting to Golgi (GO:0000042)2.53664885
115protein localization to Golgi apparatus (GO:0034067)2.52747384
116microtubule anchoring (GO:0034453)2.52586927
117regulation of hippo signaling (GO:0035330)2.52511493
118negative regulation of dendrite morphogenesis (GO:0050774)2.51929279
119L-amino acid import (GO:0043092)2.51880966
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51666071
121protein K48-linked deubiquitination (GO:0071108)2.51384399
122negative regulation of neurotransmitter secretion (GO:0046929)2.51347246
123prepulse inhibition (GO:0060134)2.48782851
124regulation of vesicle fusion (GO:0031338)2.48142950
125central nervous system neuron axonogenesis (GO:0021955)2.47725452
126positive regulation of dendritic spine morphogenesis (GO:0061003)2.47311064
127ventricular system development (GO:0021591)2.47210585
128neuronal ion channel clustering (GO:0045161)2.46551474
129cell differentiation in hindbrain (GO:0021533)2.46161896
130positive regulation of synapse assembly (GO:0051965)2.45699988
131regulation of cardiac muscle hypertrophy (GO:0010611)2.42496002
132limb bud formation (GO:0060174)2.42002189
133protein polyglutamylation (GO:0018095)2.39409319
134artery development (GO:0060840)2.39343853
135regulation of sarcomere organization (GO:0060297)2.39084677
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38089304
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.38089304
138regulation of translation, ncRNA-mediated (GO:0045974)2.38089304
139neural tube formation (GO:0001841)2.37256175
140DNA methylation involved in gamete generation (GO:0043046)2.37212004
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.37117630
142cAMP catabolic process (GO:0006198)2.36707389
143regulation of muscle hypertrophy (GO:0014743)2.36130243
144cerebral cortex radially oriented cell migration (GO:0021799)2.33493070
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33154414
146negative chemotaxis (GO:0050919)2.32569028
147cyclic nucleotide catabolic process (GO:0009214)2.31756454
148regulation of muscle adaptation (GO:0043502)2.31670785
149regulation of meiosis I (GO:0060631)2.31126513
150acrosome reaction (GO:0007340)2.30577064
151snRNA transcription (GO:0009301)2.29761591
152microtubule nucleation (GO:0007020)2.28715977
153lymphangiogenesis (GO:0001946)2.27250271
154cardiac muscle hypertrophy (GO:0003300)2.26967415
155regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.25768940
156negative regulation of protein localization to cell surface (GO:2000009)2.25600573
157dorsal/ventral axis specification (GO:0009950)2.25078487
158positive regulation of developmental pigmentation (GO:0048087)2.24189176
159centriole replication (GO:0007099)2.22951862
160limb development (GO:0060173)2.22466951
161appendage development (GO:0048736)2.22466951
162negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.22395983
163neuronal action potential (GO:0019228)2.22285553
164cardiac myofibril assembly (GO:0055003)2.21271611
165early endosome to late endosome transport (GO:0045022)2.20948341
166myofibril assembly (GO:0030239)2.19989765
167serotonin metabolic process (GO:0042428)2.18944017
168negative regulation of sodium ion transport (GO:0010766)2.18674711
169male meiosis (GO:0007140)2.18546983
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.17278342
171negative regulation of systemic arterial blood pressure (GO:0003085)2.17174472
172primary amino compound metabolic process (GO:1901160)2.15048924
173striated muscle hypertrophy (GO:0014897)2.14791695
174regulation of alkaline phosphatase activity (GO:0010692)2.14649775
175positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.13086938
176regulation of cell communication by electrical coupling (GO:0010649)2.12787508
177labyrinthine layer development (GO:0060711)2.12544838
178acrosome assembly (GO:0001675)2.12513001
179cilium movement (GO:0003341)2.12416336
180regulation of DNA endoreduplication (GO:0032875)2.12216820
181sperm motility (GO:0030317)2.10386238
182regulation of skeletal muscle cell differentiation (GO:2001014)2.09907737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91568679
2GBX2_23144817_ChIP-Seq_PC3_Human3.52619947
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88916588
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67340912
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50994912
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50033008
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44656243
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44043544
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21721959
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21721959
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12363272
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.10627991
13TAF15_26573619_Chip-Seq_HEK293_Human2.06536709
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02571505
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99063497
16REST_21632747_ChIP-Seq_MESCs_Mouse1.97837446
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97433933
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95847479
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94857082
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93461803
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89556193
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.88590529
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87870258
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.87724791
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87470753
26SMAD4_21799915_ChIP-Seq_A2780_Human1.86851386
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78720486
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76296477
29AR_21572438_ChIP-Seq_LNCaP_Human1.76159302
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75716182
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72778002
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72467235
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71232019
34DROSHA_22980978_ChIP-Seq_HELA_Human1.70899591
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.65448747
36P300_19829295_ChIP-Seq_ESCs_Human1.64766569
37EWS_26573619_Chip-Seq_HEK293_Human1.62561227
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.62510764
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62053959
40CBP_20019798_ChIP-Seq_JUKART_Human1.62053959
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61773905
42FUS_26573619_Chip-Seq_HEK293_Human1.60469078
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60271620
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.57814653
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49818726
46RNF2_27304074_Chip-Seq_NSC_Mouse1.49569468
47ZNF274_21170338_ChIP-Seq_K562_Hela1.49513405
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48737368
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47946288
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47634518
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47381144
52* STAT3_23295773_ChIP-Seq_U87_Human1.47307136
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.46579912
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.46406057
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45443027
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45273012
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45177180
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43288638
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42358299
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41634763
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.40036473
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.39415885
63IGF1R_20145208_ChIP-Seq_DFB_Human1.39380689
64TP53_16413492_ChIP-PET_HCT116_Human1.37814227
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37343798
66AHR_22903824_ChIP-Seq_MCF-7_Human1.37272153
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36768115
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.36598049
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.35885667
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.32072741
71TCF4_23295773_ChIP-Seq_U87_Human1.31090170
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30061579
73* AR_25329375_ChIP-Seq_VCAP_Human1.29203329
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27061814
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26600164
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26354211
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26113115
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25993026
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23268240
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23268240
81* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22772528
82* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22772528
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22165946
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.21986877
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.20059906
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20025234
87VDR_22108803_ChIP-Seq_LS180_Human1.19518155
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19054374
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.18845712
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.18700649
91RUNX2_22187159_ChIP-Seq_PCA_Human1.17329389
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17190106
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.16398766
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15718314
95TCF4_22108803_ChIP-Seq_LS180_Human1.14991829
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14796800
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14096693
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14019458
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13916466
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13760202
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13470160
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13141466
103* AR_19668381_ChIP-Seq_PC3_Human1.13010251
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12941534
105P53_22387025_ChIP-Seq_ESCs_Mouse1.12752362
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.11554875
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11519185
108ER_23166858_ChIP-Seq_MCF-7_Human1.11327896
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.10248579
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.09744653
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09604819
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09438568
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.09425303
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08474922
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.07139451
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06721987
117KDM2B_26808549_Chip-Seq_REH_Human1.06655650
118* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06599467
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06429931
120BCAT_22108803_ChIP-Seq_LS180_Human1.06104161
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05767623
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04438490
123TP53_18474530_ChIP-ChIP_U2OS_Human1.03469967
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.03220259
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02732006
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02667682
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01938999
128RING1B_27294783_Chip-Seq_ESCs_Mouse1.01932442
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.99570309
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98519432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.74227360
2MP0003880_abnormal_central_pattern3.99626981
3MP0004270_analgesia3.40425661
4MP0003635_abnormal_synaptic_transmissio3.29079074
5MP0009046_muscle_twitch2.88269506
6MP0009745_abnormal_behavioral_response2.73849148
7MP0002063_abnormal_learning/memory/cond2.73673520
8MP0002064_seizures2.56471415
9MP0002572_abnormal_emotion/affect_behav2.47624705
10MP0000569_abnormal_digit_pigmentation2.46159275
11MP0001486_abnormal_startle_reflex2.45984608
12MP0003787_abnormal_imprinting2.45301312
13MP0001968_abnormal_touch/_nociception2.43628533
14MP0008057_abnormal_DNA_replication2.36100178
15MP0000778_abnormal_nervous_system2.28633506
16MP0002272_abnormal_nervous_system2.25695159
17MP0002734_abnormal_mechanical_nocicepti2.25207587
18MP0005423_abnormal_somatic_nervous2.08804132
19MP0002735_abnormal_chemical_nociception1.95275131
20MP0001440_abnormal_grooming_behavior1.92458195
21MP0004858_abnormal_nervous_system1.90760395
22MP0002184_abnormal_innervation1.87840954
23MP0000383_abnormal_hair_follicle1.87114397
24MP0001501_abnormal_sleep_pattern1.84333395
25MP0006276_abnormal_autonomic_nervous1.81606427
26MP0002067_abnormal_sensory_capabilities1.80895100
27MP0005275_abnormal_skin_tensile1.78970745
28MP0002736_abnormal_nociception_after1.78360919
29MP0003122_maternal_imprinting1.72194437
30MP0008877_abnormal_DNA_methylation1.68790385
31MP0005503_abnormal_tendon_morphology1.66685838
32MP0000427_abnormal_hair_cycle1.66441747
33MP0009780_abnormal_chondrocyte_physiolo1.65994958
34MP0001984_abnormal_olfaction1.64574833
35MP0005410_abnormal_fertilization1.62150032
36MP0002733_abnormal_thermal_nociception1.61851038
37MP0005386_behavior/neurological_phenoty1.54119012
38MP0004924_abnormal_behavior1.54119012
39MP0010386_abnormal_urinary_bladder1.53829970
40MP0001970_abnormal_pain_threshold1.52733174
41MP0003646_muscle_fatigue1.51279439
42MP0000955_abnormal_spinal_cord1.51224769
43MP0003950_abnormal_plasma_membrane1.49898740
44MP0002557_abnormal_social/conspecific_i1.48568013
45MP0003121_genomic_imprinting1.48313158
46MP0005394_taste/olfaction_phenotype1.45825995
47MP0005499_abnormal_olfactory_system1.45825995
48MP0005623_abnormal_meninges_morphology1.45584404
49MP0003183_abnormal_peptide_metabolism1.44882735
50MP0001188_hyperpigmentation1.41840725
51MP0002882_abnormal_neuron_morphology1.41832951
52MP0004811_abnormal_neuron_physiology1.41560956
53MP0004036_abnormal_muscle_relaxation1.34103138
54MP0002160_abnormal_reproductive_system1.34047822
55MP0008569_lethality_at_weaning1.31969210
56MP0003937_abnormal_limbs/digits/tail_de1.30957724
57MP0005187_abnormal_penis_morphology1.29470379
58MP0010678_abnormal_skin_adnexa1.27476157
59MP0004084_abnormal_cardiac_muscle1.24643334
60MP0002102_abnormal_ear_morphology1.23614407
61MP0001879_abnormal_lymphatic_vessel1.22935138
62MP0001905_abnormal_dopamine_level1.20996156
63MP0001299_abnormal_eye_distance/1.19557598
64MP0001986_abnormal_taste_sensitivity1.18704495
65MP0005171_absent_coat_pigmentation1.17797698
66MP0005174_abnormal_tail_pigmentation1.17374043
67MP0004885_abnormal_endolymph1.16592247
68MP0002066_abnormal_motor_capabilities/c1.16461831
69MP0002822_catalepsy1.15729020
70MP0005646_abnormal_pituitary_gland1.13565991
71MP0002009_preneoplasia1.12839712
72MP0005551_abnormal_eye_electrophysiolog1.12646744
73MP0002152_abnormal_brain_morphology1.11625607
74MP0004742_abnormal_vestibular_system1.06890032
75MP0002127_abnormal_cardiovascular_syste1.05563917
76MP0004145_abnormal_muscle_electrophysio1.05101478
77MP0000920_abnormal_myelination1.02359414
78MP0003633_abnormal_nervous_system1.01442443
79MP0002752_abnormal_somatic_nervous1.01350752
80MP0006292_abnormal_olfactory_placode1.01340806
81MP0002638_abnormal_pupillary_reflex1.00864016
82MP0000631_abnormal_neuroendocrine_gland1.00833607
83MP0005645_abnormal_hypothalamus_physiol1.00107984
84MP0001177_atelectasis0.99839956
85MP0001529_abnormal_vocalization0.99561623
86MP0005409_darkened_coat_color0.98044534
87MP0003935_abnormal_craniofacial_develop0.97537883
88MP0000013_abnormal_adipose_tissue0.97426044
89MP0003631_nervous_system_phenotype0.97208636
90MP0001963_abnormal_hearing_physiology0.95887223
91MP0003698_abnormal_male_reproductive0.95813203
92MP0003634_abnormal_glial_cell0.95252287
93MP0003938_abnormal_ear_development0.92899159
94MP0004043_abnormal_pH_regulation0.91372287
95MP0001929_abnormal_gametogenesis0.91236673
96MP0002909_abnormal_adrenal_gland0.91018323
97MP0003632_abnormal_nervous_system0.90578450
98MP0002109_abnormal_limb_morphology0.90051289
99MP0001502_abnormal_circadian_rhythm0.89672586
100MP0003861_abnormal_nervous_system0.88091559
101MP0002837_dystrophic_cardiac_calcinosis0.88029811
102MP0003890_abnormal_embryonic-extraembry0.87870362
103MP0002229_neurodegeneration0.87763822
104MP0005670_abnormal_white_adipose0.87539446
105MP0003123_paternal_imprinting0.87326852
106MP0004130_abnormal_muscle_cell0.87164617
107MP0003119_abnormal_digestive_system0.86794556
108MP0005620_abnormal_muscle_contractility0.86373038
109MP0004085_abnormal_heartbeat0.85013015
110MP0004142_abnormal_muscle_tone0.84786172
111MP0001958_emphysema0.84666818
112MP0003329_amyloid_beta_deposits0.84634754
113MP0003879_abnormal_hair_cell0.83121333
114MP0002876_abnormal_thyroid_physiology0.82890511
115MP0003941_abnormal_skin_development0.81649361
116MP0004272_abnormal_basement_membrane0.81542559
117MP0002095_abnormal_skin_pigmentation0.81291165
118MP0000749_muscle_degeneration0.80818021
119MP0005389_reproductive_system_phenotype0.77303404
120MP0009384_cardiac_valve_regurgitation0.76554686
121MP0000647_abnormal_sebaceous_gland0.76067713
122MP0002108_abnormal_muscle_morphology0.75372703
123MP0008961_abnormal_basal_metabolism0.73291964
124MP0002210_abnormal_sex_determination0.72346691
125MP0003755_abnormal_palate_morphology0.72186346
126MP0003690_abnormal_glial_cell0.70699717
127MP0003045_fibrosis0.69926672
128MP0002751_abnormal_autonomic_nervous0.69135957
129MP0009250_abnormal_appendicular_skeleto0.69019120
130MP0008789_abnormal_olfactory_epithelium0.68671422
131MP0004134_abnormal_chest_morphology0.68364104
132MP0000751_myopathy0.67509667
133MP0000026_abnormal_inner_ear0.67330939
134MP0002233_abnormal_nose_morphology0.67194655
135MP0000534_abnormal_ureter_morphology0.66571015
136MP0001943_abnormal_respiration0.65846151
137MP0005253_abnormal_eye_physiology0.65809193
138MP0001485_abnormal_pinna_reflex0.63884185
139MP0006072_abnormal_retinal_apoptosis0.62397672
140MP0003137_abnormal_impulse_conducting0.62213235
141MP0003385_abnormal_body_wall0.61533146
142MP0004215_abnormal_myocardial_fiber0.61425811

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.27823082
2Focal seizures (HP:0007359)4.46840209
3Epileptic encephalopathy (HP:0200134)3.94792959
4Chronic hepatic failure (HP:0100626)3.87217902
5Febrile seizures (HP:0002373)3.85207125
6Atonic seizures (HP:0010819)3.71605441
7Myokymia (HP:0002411)3.68262382
8Abnormality of the ischium (HP:0003174)3.32222655
9Progressive cerebellar ataxia (HP:0002073)3.28841435
10Hyperventilation (HP:0002883)3.10986865
11Absent/shortened dynein arms (HP:0200106)3.08462401
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.08462401
13Abnormality of the lower motor neuron (HP:0002366)3.03132481
14Drooling (HP:0002307)3.01869040
15Excessive salivation (HP:0003781)3.01869040
16Absence seizures (HP:0002121)2.96842783
17Dialeptic seizures (HP:0011146)2.96298821
18Abnormality of the corticospinal tract (HP:0002492)2.91459802
19Broad-based gait (HP:0002136)2.86151395
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.75904232
21Action tremor (HP:0002345)2.75567784
22Gaze-evoked nystagmus (HP:0000640)2.71812576
23Pancreatic cysts (HP:0001737)2.68236644
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66875576
25Generalized tonic-clonic seizures (HP:0002069)2.65645149
26Absent speech (HP:0001344)2.64746164
27Visual hallucinations (HP:0002367)2.62445319
28Abnormality of the renal cortex (HP:0011035)2.62360658
29Amblyopia (HP:0000646)2.61431128
30Overgrowth (HP:0001548)2.54666327
31Aqueductal stenosis (HP:0002410)2.47370001
32Insidious onset (HP:0003587)2.47060910
33Termporal pattern (HP:0011008)2.47060910
34Tubulointerstitial nephritis (HP:0001970)2.46300268
35Truncal obesity (HP:0001956)2.44456203
36Abnormality of the renal medulla (HP:0100957)2.38980987
37Abnormal pancreas size (HP:0012094)2.32769806
38Hemiparesis (HP:0001269)2.32165178
39Supranuclear gaze palsy (HP:0000605)2.31877155
40Hypoplastic ischia (HP:0003175)2.30134901
41Urinary bladder sphincter dysfunction (HP:0002839)2.28943517
42Amyotrophic lateral sclerosis (HP:0007354)2.28254184
43Nephronophthisis (HP:0000090)2.24986510
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.23209795
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23209795
46Short chin (HP:0000331)2.22207845
47Genital tract atresia (HP:0001827)2.21979802
48Inappropriate behavior (HP:0000719)2.21138685
49Calf muscle hypertrophy (HP:0008981)2.20917478
50Hepatoblastoma (HP:0002884)2.18632432
51Genetic anticipation (HP:0003743)2.18479277
52Truncal ataxia (HP:0002078)2.18004582
53Fair hair (HP:0002286)2.16903137
54Abnormality of salivation (HP:0100755)2.16894817
55Abnormal respiratory motile cilium physiology (HP:0012261)2.15933824
56Absent frontal sinuses (HP:0002688)2.13950515
57Vaginal atresia (HP:0000148)2.13586870
58Short tibia (HP:0005736)2.12870232
59Tubular atrophy (HP:0000092)2.12337535
60Abnormal ciliary motility (HP:0012262)2.09834917
61Lip pit (HP:0100267)2.09531702
62Dysdiadochokinesis (HP:0002075)2.05175389
63Pancreatic fibrosis (HP:0100732)2.03309718
64Molar tooth sign on MRI (HP:0002419)2.01310976
65Abnormality of midbrain morphology (HP:0002418)2.01310976
66Ankle clonus (HP:0011448)1.99563711
67Aplasia of the phalanges of the hand (HP:0009802)1.98954379
68Aplasia involving bones of the extremities (HP:0009825)1.98954379
69Aplasia involving bones of the upper limbs (HP:0009823)1.98954379
70Morphological abnormality of the middle ear (HP:0008609)1.98845910
71Mutism (HP:0002300)1.98702572
72Exotropia (HP:0000577)1.96735658
73Protruding tongue (HP:0010808)1.96455926
74Dysmetria (HP:0001310)1.96421530
75Cutaneous syndactyly (HP:0012725)1.96182851
76Sensory axonal neuropathy (HP:0003390)1.91977069
77Widely spaced teeth (HP:0000687)1.91686778
78Type II lissencephaly (HP:0007260)1.91450918
79Neurofibrillary tangles (HP:0002185)1.91188957
80Poor coordination (HP:0002370)1.90976900
81Hypoplastic iliac wings (HP:0002866)1.90426880
82Muscle hypertrophy of the lower extremities (HP:0008968)1.87779058
83Cerebral inclusion bodies (HP:0100314)1.87692570
84Renal cortical cysts (HP:0000803)1.86956870
85Impaired vibration sensation in the lower limbs (HP:0002166)1.86782372
86Generalized hypopigmentation of hair (HP:0011358)1.84133775
87Limited hip movement (HP:0008800)1.83819481
88Lower limb muscle weakness (HP:0007340)1.83465340
89Heterotopia (HP:0002282)1.83415550
90Abnormal respiratory epithelium morphology (HP:0012253)1.83109181
91Abnormal respiratory motile cilium morphology (HP:0005938)1.83109181
92Narrow palate (HP:0000189)1.83029107
93Abnormality of the pubic bones (HP:0003172)1.82678852
94Hypoplasia of the iris (HP:0007676)1.82012496
95Hypoplastic labia majora (HP:0000059)1.81902371
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80897129
97Spastic gait (HP:0002064)1.80483693
98Hyperkalemia (HP:0002153)1.80482447
99Macroorchidism (HP:0000053)1.79605690
100Cystic liver disease (HP:0006706)1.78574316
101Cerebellar dysplasia (HP:0007033)1.77721937
102Tubulointerstitial abnormality (HP:0001969)1.77666390
103Inability to walk (HP:0002540)1.77332453
104Abnormality of the labia majora (HP:0012881)1.75784326
105Progressive inability to walk (HP:0002505)1.74652463
106Urinary urgency (HP:0000012)1.74212722
107Medial flaring of the eyebrow (HP:0010747)1.73621040
108Bilateral microphthalmos (HP:0007633)1.71957689
109Papillary thyroid carcinoma (HP:0002895)1.71355520
110Wide intermamillary distance (HP:0006610)1.70070008
111Relative macrocephaly (HP:0004482)1.70068034
112Long clavicles (HP:0000890)1.69538448
113Neoplasm of the heart (HP:0100544)1.69096411
114Nephrogenic diabetes insipidus (HP:0009806)1.69049289
115Blue irides (HP:0000635)1.68984255
116Epileptiform EEG discharges (HP:0011182)1.68837951
117Abnormality of the labia minora (HP:0012880)1.68630311
118True hermaphroditism (HP:0010459)1.68599419
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67838834
120Short 4th metacarpal (HP:0010044)1.67838834
121Cupped ear (HP:0000378)1.67267379
122Chromsome breakage (HP:0040012)1.67173278
123Pulmonic stenosis (HP:0001642)1.66973018
124Intention tremor (HP:0002080)1.66000928
125Volvulus (HP:0002580)1.65726733
126Megalencephaly (HP:0001355)1.65069502
127Optic nerve hypoplasia (HP:0000609)1.64981520
128Polydipsia (HP:0001959)1.64789355
129Abnormal drinking behavior (HP:0030082)1.64789355
130Osteomalacia (HP:0002749)1.64289392
131Anterior segment dysgenesis (HP:0007700)1.64159006
132Small hand (HP:0200055)1.63980013
133Abnormal biliary tract morphology (HP:0012440)1.63939584
134Midline defect of the nose (HP:0004122)1.63488244
135Buphthalmos (HP:0000557)1.63208803
136Clumsiness (HP:0002312)1.63175319
137Bell-shaped thorax (HP:0001591)1.63118353
138Cutaneous finger syndactyly (HP:0010554)1.61635395
139Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61557386
140Abnormality of incisor morphology (HP:0011063)1.61420667
141Ulnar claw (HP:0001178)1.61383245
142Poor eye contact (HP:0000817)1.60067484
143Gait imbalance (HP:0002141)1.60016492
144Abnormality of ocular smooth pursuit (HP:0000617)1.59752056
145Fetal akinesia sequence (HP:0001989)1.59302944
146Cubitus valgus (HP:0002967)1.58995140
147Bifid tongue (HP:0010297)1.58957831
148Deeply set eye (HP:0000490)1.58537172
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58384616
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.58246187
151Depression (HP:0000716)1.57748779
152Congenital primary aphakia (HP:0007707)1.57736825
153EEG with generalized epileptiform discharges (HP:0011198)1.57631314
154Abnormality of the calf musculature (HP:0001430)1.57599739
155Lower limb amyotrophy (HP:0007210)1.57423904
156Neoplasm of the oral cavity (HP:0100649)1.57412113
157Decreased lacrimation (HP:0000633)1.57128180
158Intellectual disability, moderate (HP:0002342)1.55846145
159Hamartoma of the eye (HP:0010568)1.55748472
160Open mouth (HP:0000194)1.54906273
161Short foot (HP:0001773)1.54668648
162Postural instability (HP:0002172)1.54371337
163Scanning speech (HP:0002168)1.54273751
164Specific learning disability (HP:0001328)1.53645292
165Abnormality of the astrocytes (HP:0100707)1.53507235
166Astrocytoma (HP:0009592)1.53507235
167Obstructive sleep apnea (HP:0002870)1.52170333
168Impaired vibratory sensation (HP:0002495)1.51913011
169Impaired smooth pursuit (HP:0007772)1.51729364
170Gastroesophageal reflux (HP:0002020)1.49836593
171Stereotypic behavior (HP:0000733)1.49574022
172Decreased motor nerve conduction velocity (HP:0003431)1.49336656
173Abnormality of the nasal septum (HP:0000419)1.48160761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.77901444
2EPHA43.38891283
3MARK13.15125768
4MAP3K42.70146887
5MAP3K92.59012801
6CASK2.57222373
7OBSCN2.41274800
8ACVR1B2.30346490
9GRK52.23186890
10MAP2K72.18407604
11PNCK2.06128888
12NTRK22.05983820
13MINK12.01071705
14NTRK11.86225903
15PLK21.78005892
16FGFR21.74268361
17RIPK41.69679880
18PAK61.65370470
19PINK11.64549148
20WNK11.63789405
21LATS11.63214146
22CDK121.60475181
23BRD41.58254631
24MAPK131.57740935
25DAPK21.56706966
26STK38L1.55775688
27MAP2K41.52159834
28TYRO31.44566611
29KSR11.40262387
30AKT31.39448542
31CAMK1G1.38220549
32STK391.37601995
33SIK21.31387188
34BMPR21.25298363
35CDK51.24420648
36FRK1.24160333
37BCR1.23319046
38PRPF4B1.22164964
39PDK41.21658159
40PDK31.21658159
41PIK3CA1.18116152
42OXSR11.17694115
43PIK3CG1.16484949
44ERBB31.14394349
45GRK71.13968617
46PRKD31.12849011
47SGK4941.10220749
48SGK2231.10220749
49TNIK1.08684900
50NUAK11.08199235
51KSR21.02497953
52WNK31.00208507
53PKN10.98616863
54SGK20.97491323
55CAMK2A0.97171610
56CAMKK10.96394704
57PTK2B0.96030615
58NLK0.95982790
59MARK20.94467780
60PRKCG0.91831147
61MAP3K130.90620072
62NEK90.88874491
63PDGFRB0.88086169
64STK110.87959712
65MET0.87690140
66MAP3K60.86239371
67SGK10.82825595
68PDK20.81850075
69CAMKK20.80541053
70PLK40.80112787
71PAK30.79909124
72CAMK1D0.79356606
73STK380.78625650
74GRK10.78323959
75UHMK10.78319436
76TRPM70.77188462
77MAP4K20.76571421
78STK30.75873998
79MAP3K20.75530240
80WNK40.74389716
81MAP3K70.72301524
82CAMK2B0.71763597
83DYRK1A0.69273133
84PRKAA10.67385525
85PRKCE0.66881925
86NEK60.66834350
87CSNK1G20.66563860
88DDR20.66433007
89FLT30.65504389
90LATS20.65345406
91CDK180.65118234
92PHKG20.65063064
93PHKG10.65063064
94FGR0.64162326
95SGK30.63925506
96FES0.63291364
97MELK0.63274402
98CDK140.62765068
99ADRBK20.62466997
100CDK150.62037785
101FGFR10.61736244
102CAMK40.60192359
103MAPK100.59110704
104ICK0.59068673
105PDGFRA0.58736656
106CDC42BPA0.58351511
107CDK190.57803668
108ADRBK10.55444152
109ZAK0.53439826
110SIK30.51686376
111RPS6KB10.51471436
112PRKAA20.51109937
113CSNK1D0.50653170
114MAPK70.50245213
115PRKACB0.50059139
116CDK11A0.49817512
117MYLK0.49385965
118RET0.48253617
119CAMK10.47679623
120DAPK10.47203485
121ERBB20.46463786
122RPS6KA30.46223863
123TLK10.45705502
124MAP3K120.45186821
125PRKCZ0.44892641
126MKNK20.44635153
127ROCK10.44431539
128PKN20.44038780
129PRKG10.43972025
130FER0.43816730
131DMPK0.42163320
132CAMK2D0.40238140
133ATM0.40175364
134BMPR1B0.39647247
135CCNB10.38550044
136MOS0.38437001
137GSK3B0.37300353
138INSRR0.36684424
139CSNK1G10.36089902
140TIE10.33639957

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29803398
2Long-term potentiation_Homo sapiens_hsa047202.41722855
3Glutamatergic synapse_Homo sapiens_hsa047242.40420215
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33605831
5Circadian entrainment_Homo sapiens_hsa047132.31474353
6GABAergic synapse_Homo sapiens_hsa047272.23257494
7Synaptic vesicle cycle_Homo sapiens_hsa047212.22928456
8Morphine addiction_Homo sapiens_hsa050322.13987830
9Olfactory transduction_Homo sapiens_hsa047402.09170728
10Amphetamine addiction_Homo sapiens_hsa050312.08136934
11Salivary secretion_Homo sapiens_hsa049701.93557299
12Dopaminergic synapse_Homo sapiens_hsa047281.91377039
13Taste transduction_Homo sapiens_hsa047421.87931551
14Renin secretion_Homo sapiens_hsa049241.87794128
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82221912
16Serotonergic synapse_Homo sapiens_hsa047261.79237345
17Long-term depression_Homo sapiens_hsa047301.73270657
18Cholinergic synapse_Homo sapiens_hsa047251.65564781
19Circadian rhythm_Homo sapiens_hsa047101.61379667
20Axon guidance_Homo sapiens_hsa043601.60161895
21Gastric acid secretion_Homo sapiens_hsa049711.55499495
22Oxytocin signaling pathway_Homo sapiens_hsa049211.53731384
23Insulin secretion_Homo sapiens_hsa049111.49334303
24ABC transporters_Homo sapiens_hsa020101.49118884
25Calcium signaling pathway_Homo sapiens_hsa040201.47809142
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46157597
27Dorso-ventral axis formation_Homo sapiens_hsa043201.43047554
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37646532
29Cocaine addiction_Homo sapiens_hsa050301.34931171
30cAMP signaling pathway_Homo sapiens_hsa040241.33444336
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33392485
32GnRH signaling pathway_Homo sapiens_hsa049121.31980077
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31699607
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30686323
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29839866
36Phototransduction_Homo sapiens_hsa047441.28001193
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24711492
38Gap junction_Homo sapiens_hsa045401.23625973
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23045024
40TGF-beta signaling pathway_Homo sapiens_hsa043501.18616268
41ErbB signaling pathway_Homo sapiens_hsa040121.17194111
42ECM-receptor interaction_Homo sapiens_hsa045121.15811197
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15344278
44Glioma_Homo sapiens_hsa052141.13717827
45Fanconi anemia pathway_Homo sapiens_hsa034601.13362153
46Type II diabetes mellitus_Homo sapiens_hsa049301.13243271
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13135552
48Collecting duct acid secretion_Homo sapiens_hsa049661.11797130
49Estrogen signaling pathway_Homo sapiens_hsa049151.10053717
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.04270555
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03886806
52Melanogenesis_Homo sapiens_hsa049161.02922946
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01703192
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.99860984
55Nitrogen metabolism_Homo sapiens_hsa009100.97840659
56Choline metabolism in cancer_Homo sapiens_hsa052310.96857546
57Oocyte meiosis_Homo sapiens_hsa041140.96720446
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92510722
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91357588
60Dilated cardiomyopathy_Homo sapiens_hsa054140.90583869
61Lysine degradation_Homo sapiens_hsa003100.90391354
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89960923
63MAPK signaling pathway_Homo sapiens_hsa040100.85535759
64Wnt signaling pathway_Homo sapiens_hsa043100.83166758
65FoxO signaling pathway_Homo sapiens_hsa040680.82152900
66Butanoate metabolism_Homo sapiens_hsa006500.81117955
67Inositol phosphate metabolism_Homo sapiens_hsa005620.80920427
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80578917
69Ras signaling pathway_Homo sapiens_hsa040140.80257678
70Fatty acid biosynthesis_Homo sapiens_hsa000610.78592957
71MicroRNAs in cancer_Homo sapiens_hsa052060.77540348
72Pancreatic secretion_Homo sapiens_hsa049720.76335575
73Rap1 signaling pathway_Homo sapiens_hsa040150.75812459
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74385454
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.73626569
76mTOR signaling pathway_Homo sapiens_hsa041500.72206821
77Renal cell carcinoma_Homo sapiens_hsa052110.71459562
78Hedgehog signaling pathway_Homo sapiens_hsa043400.69085602
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.69050905
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68960910
81Cardiac muscle contraction_Homo sapiens_hsa042600.68870752
82Basal transcription factors_Homo sapiens_hsa030220.67111148
83Platelet activation_Homo sapiens_hsa046110.66494177
84Vibrio cholerae infection_Homo sapiens_hsa051100.64505459
85Endometrial cancer_Homo sapiens_hsa052130.64006999
86Homologous recombination_Homo sapiens_hsa034400.63736413
87Protein digestion and absorption_Homo sapiens_hsa049740.62841235
88Ovarian steroidogenesis_Homo sapiens_hsa049130.62548628
89Prostate cancer_Homo sapiens_hsa052150.61318985
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61018880
91Alcoholism_Homo sapiens_hsa050340.60525997
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60108099
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60104178
94VEGF signaling pathway_Homo sapiens_hsa043700.59254234
95Vitamin B6 metabolism_Homo sapiens_hsa007500.57304887
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55709252
97Thyroid hormone synthesis_Homo sapiens_hsa049180.55663200
98African trypanosomiasis_Homo sapiens_hsa051430.54742402
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.54684235
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53317223
101Regulation of autophagy_Homo sapiens_hsa041400.53271429
102Small cell lung cancer_Homo sapiens_hsa052220.52560845
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52495031
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.50401202
105Colorectal cancer_Homo sapiens_hsa052100.49948106
106Tight junction_Homo sapiens_hsa045300.49907980
107Prolactin signaling pathway_Homo sapiens_hsa049170.49731122
108Endocytosis_Homo sapiens_hsa041440.49675040
109Melanoma_Homo sapiens_hsa052180.49255701
110Ether lipid metabolism_Homo sapiens_hsa005650.48700551
111Glucagon signaling pathway_Homo sapiens_hsa049220.46266296
112Hippo signaling pathway_Homo sapiens_hsa043900.45965534
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45374037
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45316911
115Non-small cell lung cancer_Homo sapiens_hsa052230.44715520
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44527280
117Chemokine signaling pathway_Homo sapiens_hsa040620.44502315
118Mineral absorption_Homo sapiens_hsa049780.44274954
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43637362
120Focal adhesion_Homo sapiens_hsa045100.43033308
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41926349
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41694195
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40690066
124Basal cell carcinoma_Homo sapiens_hsa052170.40656161
125Adherens junction_Homo sapiens_hsa045200.39584611

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