MYO9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.93225986
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77537725
3negative regulation of cell killing (GO:0031342)4.77537725
4positive thymic T cell selection (GO:0045059)4.09411379
5positive regulation by symbiont of host defense response (GO:0052509)4.05770534
6modulation by symbiont of host defense response (GO:0052031)4.05770534
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05770534
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05770534
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.05770534
10modulation by symbiont of host immune response (GO:0052553)4.05770534
11detection of other organism (GO:0098543)3.93684337
12response to muramyl dipeptide (GO:0032495)3.90961140
13regulation of gamma-delta T cell differentiation (GO:0045586)3.87843542
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.79315210
15detection of bacterium (GO:0016045)3.76274617
16regulation of gamma-delta T cell activation (GO:0046643)3.68992967
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61723921
18regulation of interferon-beta biosynthetic process (GO:0045357)3.61663792
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59759716
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59759716
21detection of molecule of bacterial origin (GO:0032490)3.57068721
22detection of external biotic stimulus (GO:0098581)3.49700429
23antigen processing and presentation of endogenous antigen (GO:0019883)3.42474017
24apoptotic cell clearance (GO:0043277)3.41702572
25regulation of mast cell degranulation (GO:0043304)3.41637623
26regulation of B cell receptor signaling pathway (GO:0050855)3.35634760
27regulation of leukocyte degranulation (GO:0043300)3.32342743
28NIK/NF-kappaB signaling (GO:0038061)3.25517898
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.25297927
30negative thymic T cell selection (GO:0045060)3.22528007
31positive regulation of B cell differentiation (GO:0045579)3.22396406
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20544563
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17658598
34thymic T cell selection (GO:0045061)3.16523267
35negative T cell selection (GO:0043383)3.13911510
36detection of biotic stimulus (GO:0009595)3.13334726
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13049443
38positive regulation of histone deacetylation (GO:0031065)3.11383230
39negative regulation of interleukin-12 production (GO:0032695)3.11158902
40regulation of mast cell activation involved in immune response (GO:0033006)3.09662830
41cortical actin cytoskeleton organization (GO:0030866)3.08475001
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05805512
43regulation of integrin activation (GO:0033623)3.02819398
44macrophage activation involved in immune response (GO:0002281)3.02421670
45tolerance induction (GO:0002507)3.00102049
46positive T cell selection (GO:0043368)2.99906274
47macrophage activation (GO:0042116)2.99807849
48T-helper 1 type immune response (GO:0042088)2.98150399
49interferon-gamma-mediated signaling pathway (GO:0060333)2.95836837
50regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.94741763
51response to type I interferon (GO:0034340)2.92163682
52cellular response to type I interferon (GO:0071357)2.91967516
53type I interferon signaling pathway (GO:0060337)2.91967516
54positive regulation of interferon-alpha production (GO:0032727)2.90608261
55negative regulation of granulocyte differentiation (GO:0030853)2.90146758
56defense response to protozoan (GO:0042832)2.88870722
57positive regulation of cellular amide metabolic process (GO:0034250)2.88194497
58natural killer cell differentiation (GO:0001779)2.87530820
59B cell receptor signaling pathway (GO:0050853)2.86748397
60negative regulation of leukocyte mediated immunity (GO:0002704)2.84663395
61response to laminar fluid shear stress (GO:0034616)2.83078447
62response to protozoan (GO:0001562)2.82115598
63positive regulation of mast cell activation (GO:0033005)2.82102751
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.80992992
65neutrophil activation involved in immune response (GO:0002283)2.80493704
66regulation of T-helper 2 cell differentiation (GO:0045628)2.80485568
67mannose metabolic process (GO:0006013)2.79760628
68leukocyte aggregation (GO:0070486)2.79306071
69modulation by symbiont of host cellular process (GO:0044068)2.79056243
70regulation of B cell differentiation (GO:0045577)2.78907162
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78249175
72pinocytosis (GO:0006907)2.78226399
73negative regulation of T cell mediated immunity (GO:0002710)2.77361554
74microglial cell activation (GO:0001774)2.76792777
75T cell migration (GO:0072678)2.76606482
76negative regulation of cytokine production involved in immune response (GO:0002719)2.76555288
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.76184258
78regulation of interferon-alpha production (GO:0032647)2.76128634
79regulation of antigen processing and presentation (GO:0002577)2.74778851
80respiratory burst (GO:0045730)2.74622126
81T cell selection (GO:0045058)2.74465635
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.74018514
83cell adhesion mediated by integrin (GO:0033627)2.72995834
84regulation of mast cell activation (GO:0033003)2.72148788
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68099817
86regulation of macrophage cytokine production (GO:0010935)2.67639991
87cytoplasmic mRNA processing body assembly (GO:0033962)2.65867379
88histone H3-K4 trimethylation (GO:0080182)2.65715102
89regulation of regulated secretory pathway (GO:1903305)2.63575378
90I-kappaB phosphorylation (GO:0007252)2.63158923
91germinal center formation (GO:0002467)2.57395448
92positive regulation of mast cell degranulation (GO:0043306)2.56344436
93positive regulation of mast cell activation involved in immune response (GO:0033008)2.56344436
94cortical cytoskeleton organization (GO:0030865)2.56301561
95immunoglobulin mediated immune response (GO:0016064)2.56085560
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55146828
97positive regulation of leukocyte degranulation (GO:0043302)2.54923488
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54891247
99response to host (GO:0075136)2.54891247
100response to host defenses (GO:0052200)2.54891247
101positive regulation of natural killer cell differentiation (GO:0032825)2.54742770
102regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.53245673
103amino sugar catabolic process (GO:0046348)2.52920882
104regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52898753
105positive regulation of p38MAPK cascade (GO:1900745)2.52396901
106regulation of tolerance induction (GO:0002643)2.52066807
107neutrophil activation (GO:0042119)2.51900639
108response to host immune response (GO:0052572)2.49949553
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49949553
110leukocyte cell-cell adhesion (GO:0007159)2.48541733
111antigen processing and presentation via MHC class Ib (GO:0002475)2.47391981
112natural killer cell mediated cytotoxicity (GO:0042267)2.47320335
113natural killer cell mediated immunity (GO:0002228)2.47320335
114response to peptidoglycan (GO:0032494)2.46563759
115NLS-bearing protein import into nucleus (GO:0006607)2.45893339
116granulocyte activation (GO:0036230)2.43312158
117substrate-dependent cell migration (GO:0006929)2.41504889
118growth hormone receptor signaling pathway (GO:0060396)2.41376019
119response to fluid shear stress (GO:0034405)2.38587867
120B cell homeostasis (GO:0001782)2.38396985
121regulation of ARF GTPase activity (GO:0032312)2.38217732
122neutrophil mediated immunity (GO:0002446)2.36289385
123protein localization to endosome (GO:0036010)2.35820045
124histone H3-K4 methylation (GO:0051568)2.33912556
125myeloid cell activation involved in immune response (GO:0002275)2.32021558
126cellular extravasation (GO:0045123)2.31807680
127negative regulation of interleukin-6 production (GO:0032715)2.31152205
128endodermal cell differentiation (GO:0035987)2.30532451
129heterotypic cell-cell adhesion (GO:0034113)2.29646635
130myeloid dendritic cell activation (GO:0001773)2.29532170
131myeloid dendritic cell differentiation (GO:0043011)2.27897236
132negative regulation of erythrocyte differentiation (GO:0045647)2.27776039
133positive regulation of antigen processing and presentation (GO:0002579)2.26868423
134positive regulation of cell adhesion mediated by integrin (GO:0033630)2.26847194
135integrin-mediated signaling pathway (GO:0007229)2.25245500
136nuclear pore complex assembly (GO:0051292)2.25102726
137germ cell migration (GO:0008354)2.22478617
138regulation of cholesterol storage (GO:0010885)2.22129875
139positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20862305
140negative regulation of phagocytosis (GO:0050765)2.20138560
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.19970389
142regulation of T cell tolerance induction (GO:0002664)2.18489156
143receptor catabolic process (GO:0032801)2.18141684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.13201041
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.88162013
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52149328
4E2F7_22180533_ChIP-Seq_HELA_Human3.46349871
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.28679943
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.21467004
7MYC_22102868_ChIP-Seq_BL_Human3.13121743
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.89179683
9* VDR_21846776_ChIP-Seq_THP-1_Human2.88256925
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78287175
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69023489
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.63127991
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.61281538
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57407850
15TCF7_22412390_ChIP-Seq_EML_Mouse2.50970118
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38685544
17KDM2B_26808549_Chip-Seq_DND41_Human2.29791561
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23995643
19MAF_26560356_Chip-Seq_TH1_Human2.21404796
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21094818
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21031260
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.19035136
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.18515546
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17062643
25SCL_19346495_ChIP-Seq_HPC-7_Human2.15186970
26* VDR_24763502_ChIP-Seq_THP-1_Human2.09021831
27* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03994412
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02624836
29* SPI1_23127762_ChIP-Seq_K562_Human2.01777084
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01395037
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00774892
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98206074
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.96335825
34UTX_26944678_Chip-Seq_JUKART_Human1.95910845
35RUNX_20019798_ChIP-Seq_JUKART_Human1.92358226
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86864751
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83146219
38MYB_26560356_Chip-Seq_TH2_Human1.82261868
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79079996
40* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78600082
41MYB_26560356_Chip-Seq_TH1_Human1.75843069
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.73171520
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72703788
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68469954
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64350229
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53666269
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53603313
48SPI1_23547873_ChIP-Seq_NB4_Human1.50477447
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50280980
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.47834936
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41462802
52LXR_22292898_ChIP-Seq_THP-1_Human1.36933094
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36766481
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35176154
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35039634
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34863813
57PU_27001747_Chip-Seq_BMDM_Mouse1.33772175
58MAF_26560356_Chip-Seq_TH2_Human1.33735003
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32685458
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32063376
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31944764
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31579858
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30833087
64NCOR1_26117541_ChIP-Seq_K562_Human1.24002071
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.23741633
66RACK7_27058665_Chip-Seq_MCF-7_Human1.18743527
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17445672
68GATA3_27048872_Chip-Seq_THYMUS_Human1.17145718
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16204207
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13934390
71CLOCK_20551151_ChIP-Seq_293T_Human1.13445365
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13058731
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12137608
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.12057935
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11409999
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.10594554
77KDM2B_26808549_Chip-Seq_K562_Human1.10335340
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.10013295
79* VDR_24787735_ChIP-Seq_THP-1_Human1.09104051
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07600176
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06536272
82* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06504002
83GATA1_19941826_ChIP-Seq_K562_Human1.06154287
84* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05871780
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05307089
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05178616
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01852239
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01803254
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01386570
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01376095
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00395054
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.99896792
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99884331
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99081838
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.99003778
96ATF3_27146783_Chip-Seq_COLON_Human0.98132680
97* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97343368
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97201095
99TFEB_21752829_ChIP-Seq_HELA_Human0.96664000
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96589033
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96589033
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96545101
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96183336
104* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96049640
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95785599
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95781648
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95436558
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94545688
109BCOR_27268052_Chip-Seq_Bcells_Human0.93209603
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93182411
111GATA2_19941826_ChIP-Seq_K562_Human0.92684160
112TP53_22127205_ChIP-Seq_IMR90_Human0.91807148
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90386883
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89335426
115* BRD4_25478319_ChIP-Seq_HGPS_Human0.86835926
116UBF1/2_26484160_Chip-Seq_HMECs_Human0.86545309
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86065531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.26438960
2MP0003303_peritoneal_inflammation3.52741493
3MP0003300_gastrointestinal_ulcer2.95842042
4MP0003724_increased_susceptibility_to2.89164787
5MP0003705_abnormal_hypodermis_morpholog2.78294331
6MP0001835_abnormal_antigen_presentation2.56559807
7MP0009278_abnormal_bone_marrow2.53126769
8MP0004510_myositis2.50621167
9MP0003436_decreased_susceptibility_to2.39163972
10MP0010352_gastrointestinal_tract_polyps2.34520910
11MP0000685_abnormal_immune_system2.34472622
12MP0008438_abnormal_cutaneous_collagen2.30634618
13MP0003566_abnormal_cell_adhesion2.28766091
14MP0005058_abnormal_lysosome_morphology2.28634292
15MP0005076_abnormal_cell_differentiation2.23835687
16MP0005387_immune_system_phenotype2.12413234
17MP0001790_abnormal_immune_system2.12413234
18MP0005451_abnormal_body_composition2.10182838
19MP0003172_abnormal_lysosome_physiology2.10020160
20MP0001800_abnormal_humoral_immune2.06323803
21MP0002396_abnormal_hematopoietic_system2.02763644
22MP0002166_altered_tumor_susceptibility1.97179713
23* MP0002452_abnormal_antigen_presenting1.93123702
24* MP0002419_abnormal_innate_immunity1.88468878
25MP0008260_abnormal_autophagy1.86744892
26MP0005464_abnormal_platelet_physiology1.84614680
27MP0005000_abnormal_immune_tolerance1.84177641
28MP0004808_abnormal_hematopoietic_stem1.82385798
29MP0002723_abnormal_immune_serum1.76537531
30MP0004947_skin_inflammation1.72285299
31MP0003091_abnormal_cell_migration1.71023943
32* MP0002420_abnormal_adaptive_immunity1.69953744
33* MP0001819_abnormal_immune_cell1.69232270
34MP0010307_abnormal_tumor_latency1.65552783
35MP0003045_fibrosis1.64996597
36MP0005671_abnormal_response_to1.64001506
37MP0002405_respiratory_system_inflammati1.62409603
38MP0005174_abnormal_tail_pigmentation1.62145549
39MP0002398_abnormal_bone_marrow1.61414608
40MP0005025_abnormal_response_to1.60719762
41MP0005023_abnormal_wound_healing1.57399721
42MP0001545_abnormal_hematopoietic_system1.54486400
43MP0005397_hematopoietic_system_phenotyp1.54486400
44MP0002006_tumorigenesis1.53048242
45MP0003763_abnormal_thymus_physiology1.51901462
46MP0006082_CNS_inflammation1.50477862
47MP0003075_altered_response_to1.44600655
48MP0003448_altered_tumor_morphology1.44527402
49MP0001958_emphysema1.43205903
50MP0003279_aneurysm1.41902651
51* MP0000716_abnormal_immune_system1.41572882
52MP0000733_abnormal_muscle_development1.41482749
53MP0000689_abnormal_spleen_morphology1.41352301
54MP0000371_diluted_coat_color1.39072971
55MP0002933_joint_inflammation1.34794383
56MP0002722_abnormal_immune_system1.34744183
57MP0001873_stomach_inflammation1.34636944
58MP0003690_abnormal_glial_cell1.33987230
59MP0001533_abnormal_skeleton_physiology1.31461765
60MP0010155_abnormal_intestine_physiology1.27014640
61MP0009785_altered_susceptibility_to1.26398713
62MP0000703_abnormal_thymus_morphology1.23786806
63MP0009764_decreased_sensitivity_to1.19234103
64MP0002998_abnormal_bone_remodeling1.19213341
65* MP0002429_abnormal_blood_cell1.18241291
66MP0003191_abnormal_cellular_cholesterol1.14658408
67MP0009840_abnormal_foam_cell1.14504804
68MP0000858_altered_metastatic_potential1.13935035
69MP0001845_abnormal_inflammatory_respons1.13190514
70MP0009333_abnormal_splenocyte_physiolog1.11804906
71MP0001853_heart_inflammation1.11591023
72MP0002877_abnormal_melanocyte_morpholog1.09156770
73MP0004185_abnormal_adipocyte_glucose1.07564076
74MP0005257_abnormal_intraocular_pressure1.07358440
75MP0002148_abnormal_hypersensitivity_rea1.07000481
76MP0003453_abnormal_keratinocyte_physiol1.05517189
77MP0000465_gastrointestinal_hemorrhage1.04669909
78MP0008004_abnormal_stomach_pH1.04448577
79MP0004883_abnormal_blood_vessel1.03895944
80MP0000767_abnormal_smooth_muscle1.01162213
81MP0004381_abnormal_hair_follicle1.00862176
82MP0005166_decreased_susceptibility_to1.00277994
83MP0003329_amyloid_beta_deposits0.99999340
84MP0001243_abnormal_dermal_layer0.95700294
85MP0005164_abnormal_response_to0.95119249
86MP0003866_abnormal_defecation0.94347802
87MP0001915_intracranial_hemorrhage0.94173268
88MP0005275_abnormal_skin_tensile0.92732379
89MP0001849_ear_inflammation0.90619244
90MP0001851_eye_inflammation0.89602110
91MP0000015_abnormal_ear_pigmentation0.87924707
92MP0008961_abnormal_basal_metabolism0.85092531
93MP0003656_abnormal_erythrocyte_physiolo0.84764074
94MP0002060_abnormal_skin_morphology0.82632981
95MP0000249_abnormal_blood_vessel0.81722578
96MP0000490_abnormal_crypts_of0.81268751
97MP0003828_pulmonary_edema0.80815551
98MP0005310_abnormal_salivary_gland0.80206599
99MP0001663_abnormal_digestive_system0.78857415
100MP0005621_abnormal_cell_physiology0.78520892
101MP0010630_abnormal_cardiac_muscle0.78023435
102MP0008469_abnormal_protein_level0.78013678
103MP0002254_reproductive_system_inflammat0.77807388
104MP0000920_abnormal_myelination0.77032692
105MP0000604_amyloidosis0.75069713
106MP0005390_skeleton_phenotype0.74541186
107MP0003183_abnormal_peptide_metabolism0.74455779
108MP0000343_altered_response_to0.74167637
109MP0002168_other_aberrant_phenotype0.73907074
110MP0002019_abnormal_tumor_incidence0.73513963
111MP0005409_darkened_coat_color0.73267127
112MP0004858_abnormal_nervous_system0.71768466
113MP0005666_abnormal_adipose_tissue0.71228861
114MP0002925_abnormal_cardiovascular_devel0.71119476
115MP0003795_abnormal_bone_structure0.70274478
116MP0006054_spinal_hemorrhage0.67554956
117MP0002138_abnormal_hepatobiliary_system0.67236579
118MP0000350_abnormal_cell_proliferation0.66811175
119MP0009763_increased_sensitivity_to0.66385910
120MP0002075_abnormal_coat/hair_pigmentati0.63381593

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.56755027
2Recurrent abscess formation (HP:0002722)3.43497817
3Eczematoid dermatitis (HP:0000976)3.30125138
4Orchitis (HP:0100796)3.27270231
5Recurrent bacterial skin infections (HP:0005406)3.17085117
6Abnormality of the fingertips (HP:0001211)2.98166173
7Optic neuritis (HP:0100653)2.97970462
8Retrobulbar optic neuritis (HP:0100654)2.97970462
9Recurrent fungal infections (HP:0002841)2.92524419
10Recurrent viral infections (HP:0004429)2.87022784
11Chronic obstructive pulmonary disease (HP:0006510)2.83113198
12Obstructive lung disease (HP:0006536)2.83113198
13Systemic lupus erythematosus (HP:0002725)2.78137109
14Colitis (HP:0002583)2.69682520
15Autoimmune thrombocytopenia (HP:0001973)2.63486680
16Absent frontal sinuses (HP:0002688)2.59640097
17Vasculitis (HP:0002633)2.58510780
18Increased density of long bones (HP:0006392)2.58453630
19Shallow orbits (HP:0000586)2.57239005
20Inflammation of the large intestine (HP:0002037)2.52450043
21Vacuolated lymphocytes (HP:0001922)2.52149315
22Hematochezia (HP:0002573)2.51623552
23Mitral valve prolapse (HP:0001634)2.50749298
24Protrusio acetabuli (HP:0003179)2.48111256
25Periodontitis (HP:0000704)2.47644777
26Gastrointestinal stroma tumor (HP:0100723)2.47428317
27Cellulitis (HP:0100658)2.47160128
28Gastrointestinal inflammation (HP:0004386)2.46157728
29Osteolytic defects of the hand bones (HP:0009699)2.45606610
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.45606610
31Increased cerebral lipofuscin (HP:0011813)2.45488666
32Aortic aneurysm (HP:0004942)2.44818694
33Gastrointestinal infarctions (HP:0005244)2.43377802
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.37979172
35Myocardial infarction (HP:0001658)2.37087893
36Pulmonary infiltrates (HP:0002113)2.34622692
37Recurrent gram-negative bacterial infections (HP:0005420)2.33024565
38Ulnar bowing (HP:0003031)2.32933561
39Premature rupture of membranes (HP:0001788)2.32914887
40Recurrent cutaneous fungal infections (HP:0011370)2.30993873
41Chronic mucocutaneous candidiasis (HP:0002728)2.30993873
42Mucopolysacchariduria (HP:0008155)2.30424161
43Urinary glycosaminoglycan excretion (HP:0003541)2.30424161
44Peritonitis (HP:0002586)2.29097142
45Recurrent skin infections (HP:0001581)2.27777946
46Hyperacusis (HP:0010780)2.27633824
47Gingivitis (HP:0000230)2.23677177
48Spondylolisthesis (HP:0003302)2.22546441
49Urticaria (HP:0001025)2.19465325
50Hemoptysis (HP:0002105)2.18927131
51Amyloidosis (HP:0011034)2.18437338
52Pustule (HP:0200039)2.17788060
53Panhypogammaglobulinemia (HP:0003139)2.17149782
54Genu recurvatum (HP:0002816)2.17019654
55Ankle contracture (HP:0006466)2.16136471
56Elevated erythrocyte sedimentation rate (HP:0003565)2.15774299
57Myositis (HP:0100614)2.15684441
58Dilatation of the ascending aorta (HP:0005111)2.15058672
59Mediastinal lymphadenopathy (HP:0100721)2.13547684
60Disproportionate tall stature (HP:0001519)2.12856876
61Upper limb amyotrophy (HP:0009129)2.12415208
62Distal upper limb amyotrophy (HP:0007149)2.12415208
63Neurofibrillary tangles (HP:0002185)2.11709748
64Neuronal loss in central nervous system (HP:0002529)2.11601049
65Restrictive lung disease (HP:0002091)2.11242114
66Keratoconjunctivitis sicca (HP:0001097)2.11078737
67Encephalitis (HP:0002383)2.09856148
68Increased connective tissue (HP:0009025)2.09579295
69Epistaxis (HP:0000421)2.09468433
70Urethral obstruction (HP:0000796)2.08401427
71Thoracic kyphosis (HP:0002942)2.07646321
72Aortic dissection (HP:0002647)2.07058032
73Interstitial pulmonary disease (HP:0006530)2.03373823
74Purpura (HP:0000979)2.03217301
75Abnormality of the thoracic spine (HP:0100711)2.03202895
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03071821
77Spinal cord lesions (HP:0100561)1.99652537
78Syringomyelia (HP:0003396)1.99652537
79Upper motor neuron abnormality (HP:0002127)1.99427694
80Distal lower limb amyotrophy (HP:0008944)1.98983153
81Frequent falls (HP:0002359)1.96271725
82Abnormal platelet volume (HP:0011876)1.95891454
83Arterial thrombosis (HP:0004420)1.95447172
84Aneurysm (HP:0002617)1.94729839
85Persistence of primary teeth (HP:0006335)1.91697459
86Obstructive sleep apnea (HP:0002870)1.90606918
87Macroorchidism (HP:0000053)1.90585318
88Gingival bleeding (HP:0000225)1.90193239
89Slow saccadic eye movements (HP:0000514)1.89936177
90Cerebral inclusion bodies (HP:0100314)1.88997617
91Axonal loss (HP:0003447)1.88846548
92Broad face (HP:0000283)1.88265721
93Cervical subluxation (HP:0003308)1.87745324
94Segmental peripheral demyelination/remyelination (HP:0003481)1.87618910
95Viral hepatitis (HP:0006562)1.86920570
96Lymphopenia (HP:0001888)1.86621712
97Abnormality of macrophages (HP:0004311)1.85255587
98Hand muscle atrophy (HP:0009130)1.85182287
99T lymphocytopenia (HP:0005403)1.84912856
100Spontaneous hematomas (HP:0007420)1.84120966
101Thin bony cortex (HP:0002753)1.82719889
102Keratoconjunctivitis (HP:0001096)1.82262013
103Loss of speech (HP:0002371)1.81434574
104Abnormality of the peritoneum (HP:0002585)1.80060439
105Narrow palate (HP:0000189)1.79774379
106Petechiae (HP:0000967)1.79448140
107Acrocyanosis (HP:0001063)1.79301394
108Vertebral compression fractures (HP:0002953)1.78778634
109Increased mean platelet volume (HP:0011877)1.78650169
110Emphysema (HP:0002097)1.78476427
111Polygenic inheritance (HP:0010982)1.78272654
112Increased serum ferritin (HP:0003281)1.78244906
113Atrophic scars (HP:0001075)1.77822007
114Hepatosplenomegaly (HP:0001433)1.77024730
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.76767988
116Chronic otitis media (HP:0000389)1.76692398
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.76492305
118Abnormality of T cell number (HP:0011839)1.76297928
119Dysostosis multiplex (HP:0000943)1.76180614
120Disinhibition (HP:0000734)1.76131862
121Short 4th metacarpal (HP:0010044)1.75847457
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75847457
123High pitched voice (HP:0001620)1.74616077
124Leukocytosis (HP:0001974)1.73696125
125Prolonged bleeding time (HP:0003010)1.72650769
126Osteomyelitis (HP:0002754)1.70421391
127Radial bowing (HP:0002986)1.69749301
128Chest pain (HP:0100749)1.69213950
129Increased IgE level (HP:0003212)1.68761702
130Stomatitis (HP:0010280)1.68690573
131Abnormality of liposaccharide metabolism (HP:0010968)1.67564897
132Abnormality of glycosphingolipid metabolism (HP:0004343)1.67564897
133Abnormality of glycolipid metabolism (HP:0010969)1.67564897
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66302878
135Striae distensae (HP:0001065)1.65911169
136Nasal polyposis (HP:0100582)1.65017692
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63787127
138Meningitis (HP:0001287)1.63739797
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63224577
140Abnormality of polysaccharide metabolism (HP:0011012)1.63224577
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63224577
142Agammaglobulinemia (HP:0004432)1.63154926
143Thick nail (HP:0001805)1.63154127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.67240353
2EEF2K3.24055068
3TRIB33.15425114
4MAP4K13.14144488
5CDK122.84886077
6TTN2.77530395
7MAP3K102.71213223
8PKN22.64856400
9TYK22.09459600
10JAK32.03703742
11CAMK1D1.99750740
12ERN11.91620296
13MAP2K31.87681298
14PTK61.80802134
15CAMK1G1.75623785
16STK101.74613417
17SIK21.73843053
18ZAP701.70169192
19MAP3K141.66665870
20KIT1.65076121
21SMG11.64823084
22CDC42BPA1.64326138
23JAK11.63656982
24RIPK11.61734679
25TBK11.59022741
26EPHB11.54264643
27CSF1R1.45831766
28HCK1.40239522
29TAOK21.39241800
30MAP3K111.36974969
31CSK1.35283826
32RIPK41.34058124
33TRPM71.32966165
34MAP3K131.28768729
35IKBKB1.28220541
36RPS6KA41.23301899
37TNK21.21887144
38TGFBR21.20486186
39LRRK21.19125249
40SIK11.18840395
41FGFR41.18376779
42CHUK1.15514536
43MAP3K11.14953953
44DMPK1.14830261
45PDGFRA1.13156179
46ITK1.12789604
47BMX1.12381375
48PAK41.08985594
49MATK1.07503381
50BLK1.06939254
51IKBKE1.06388154
52CDK61.06254040
53MTOR1.05942512
54FGFR31.03344689
55FES1.02690400
56SIK31.02274945
57PDGFRB0.98143006
58ICK0.97719571
59NEK20.97118560
60KSR20.97009264
61LCK0.96440706
62BTK0.95471276
63GRK60.95440015
64SCYL20.95146758
65PRKCH0.90231364
66TAOK30.89951492
67CLK10.87053695
68BRD40.86212277
69NME20.85103842
70ALK0.84099186
71FGR0.82674638
72IRAK20.82025671
73MAP3K60.81265436
74MAP3K70.80202396
75JAK20.80052784
76MAPK70.79700262
77SYK0.79232432
78PDPK10.79053474
79MARK30.78041629
80PIM10.76797240
81MOS0.75520770
82TAOK10.74987653
83CDK40.74130613
84IRAK40.74098817
85PDK10.73486954
86PTK20.72607369
87BMPR20.72500965
88TXK0.71564061
89PAK20.71469541
90MAPK120.71108283
91STK40.71047832
92GRK70.68829589
93HIPK20.68762746
94DDR20.67001572
95RPS6KC10.65601895
96RPS6KL10.65601895
97RET0.63639748
98IRAK10.63182622
99TESK20.62961873
100EGFR0.62116204
101FLT30.61032923
102STK30.59522012
103CDK90.58400398
104CAMKK10.58314281
105RPS6KB20.57390692
106MAP3K80.56758843
107NEK90.52322427
108IRAK30.52152364
109MARK20.51976376
110PRKD20.50995765
111MAPK110.50256743
112LYN0.48022193
113EPHA30.44428903
114CDC70.43494912
115YES10.42348736
116SGK30.41887495
117ABL10.41707033
118NLK0.41670850
119MAP3K30.40577322
120MAPK40.40411672
121TYRO30.40006701
122MELK0.37853638
123FYN0.36832547
124ATR0.36537515
125RPS6KA20.35783114
126INSR0.35691306
127MAPKAPK20.35106722
128RPS6KA60.34733557

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.34360360
2Osteoclast differentiation_Homo sapiens_hsa043802.30560459
3B cell receptor signaling pathway_Homo sapiens_hsa046622.14912091
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.97088245
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.90541817
6Chronic myeloid leukemia_Homo sapiens_hsa052201.89708163
7Autoimmune thyroid disease_Homo sapiens_hsa053201.75438056
8Primary immunodeficiency_Homo sapiens_hsa053401.71552586
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66453087
10Toxoplasmosis_Homo sapiens_hsa051451.63950376
11Measles_Homo sapiens_hsa051621.62865496
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54777495
13T cell receptor signaling pathway_Homo sapiens_hsa046601.49862823
14Acute myeloid leukemia_Homo sapiens_hsa052211.47915181
15Asthma_Homo sapiens_hsa053101.47875185
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.47029547
17Tuberculosis_Homo sapiens_hsa051521.46577057
18Small cell lung cancer_Homo sapiens_hsa052221.45037009
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44417448
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44224950
21Staphylococcus aureus infection_Homo sapiens_hsa051501.42413471
22TNF signaling pathway_Homo sapiens_hsa046681.40960994
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40018005
24Viral myocarditis_Homo sapiens_hsa054161.39669062
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39399549
26Pancreatic cancer_Homo sapiens_hsa052121.37972917
27Antigen processing and presentation_Homo sapiens_hsa046121.37707383
28Malaria_Homo sapiens_hsa051441.37098623
29Shigellosis_Homo sapiens_hsa051311.36608488
30Lysine degradation_Homo sapiens_hsa003101.35873415
31Apoptosis_Homo sapiens_hsa042101.33745655
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.30531477
33Type I diabetes mellitus_Homo sapiens_hsa049401.30070871
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29890449
35Platelet activation_Homo sapiens_hsa046111.28236750
36Influenza A_Homo sapiens_hsa051641.27371894
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25797909
38Rheumatoid arthritis_Homo sapiens_hsa053231.25638861
39Proteoglycans in cancer_Homo sapiens_hsa052051.24930800
40Chemokine signaling pathway_Homo sapiens_hsa040621.24559293
41Hematopoietic cell lineage_Homo sapiens_hsa046401.22241208
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.21915890
43Hepatitis B_Homo sapiens_hsa051611.21617505
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20914733
45Pertussis_Homo sapiens_hsa051331.20215026
46MicroRNAs in cancer_Homo sapiens_hsa052061.19149608
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.18739473
48Focal adhesion_Homo sapiens_hsa045101.15713695
49Herpes simplex infection_Homo sapiens_hsa051681.15300743
50Amoebiasis_Homo sapiens_hsa051461.12888479
51Salmonella infection_Homo sapiens_hsa051321.09153757
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08478173
53Lysosome_Homo sapiens_hsa041421.07674756
54mTOR signaling pathway_Homo sapiens_hsa041501.06177173
55Notch signaling pathway_Homo sapiens_hsa043301.06089288
56VEGF signaling pathway_Homo sapiens_hsa043701.05380118
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.04240433
58Adherens junction_Homo sapiens_hsa045201.01671235
59Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01248823
60Non-small cell lung cancer_Homo sapiens_hsa052230.97660934
61Insulin resistance_Homo sapiens_hsa049310.95948106
62HTLV-I infection_Homo sapiens_hsa051660.95846633
63Legionellosis_Homo sapiens_hsa051340.95637036
64Viral carcinogenesis_Homo sapiens_hsa052030.95160326
65Caffeine metabolism_Homo sapiens_hsa002320.94711347
66ECM-receptor interaction_Homo sapiens_hsa045120.94510531
67African trypanosomiasis_Homo sapiens_hsa051430.91893295
68Prolactin signaling pathway_Homo sapiens_hsa049170.91524701
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91320580
70Colorectal cancer_Homo sapiens_hsa052100.87672456
71Other glycan degradation_Homo sapiens_hsa005110.86289892
72Prion diseases_Homo sapiens_hsa050200.85433031
73Hepatitis C_Homo sapiens_hsa051600.84613311
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83519336
75Type II diabetes mellitus_Homo sapiens_hsa049300.82759042
76GnRH signaling pathway_Homo sapiens_hsa049120.79811660
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79130380
78Glioma_Homo sapiens_hsa052140.77602406
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77211285
80Dorso-ventral axis formation_Homo sapiens_hsa043200.75505969
81HIF-1 signaling pathway_Homo sapiens_hsa040660.75473879
82Endocytosis_Homo sapiens_hsa041440.73828178
83Renal cell carcinoma_Homo sapiens_hsa052110.72673708
84Endometrial cancer_Homo sapiens_hsa052130.72307525
85Prostate cancer_Homo sapiens_hsa052150.72213095
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.71210923
87Inositol phosphate metabolism_Homo sapiens_hsa005620.69177540
88Graft-versus-host disease_Homo sapiens_hsa053320.67922791
89FoxO signaling pathway_Homo sapiens_hsa040680.66253238
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.65779218
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64228052
92ErbB signaling pathway_Homo sapiens_hsa040120.63522027
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63326016
94Choline metabolism in cancer_Homo sapiens_hsa052310.61791607
95Epstein-Barr virus infection_Homo sapiens_hsa051690.61432175
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60814263
97Phagosome_Homo sapiens_hsa041450.60543201
98Rap1 signaling pathway_Homo sapiens_hsa040150.60473374
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.60357633
100MAPK signaling pathway_Homo sapiens_hsa040100.59749893
101Pathways in cancer_Homo sapiens_hsa052000.58392200
102Estrogen signaling pathway_Homo sapiens_hsa049150.57380100
103p53 signaling pathway_Homo sapiens_hsa041150.56314587
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56225953
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56215306
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55135464
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55134661
108Bladder cancer_Homo sapiens_hsa052190.54934087
109Allograft rejection_Homo sapiens_hsa053300.54646856
110Dilated cardiomyopathy_Homo sapiens_hsa054140.54223815
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.51842951
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48050379
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46408741

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