MYOC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr9.99742224
2keratan sulfate catabolic process (GO:0042340)8.98522876
3regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 8.71258155
4lung epithelium development (GO:0060428)8.70498377
5embryonic camera-type eye development (GO:0031076)7.91950867
6limb bud formation (GO:0060174)7.81146275
7protein localization to cell surface (GO:0034394)7.41269347
8organ growth (GO:0035265)7.37014908
9muscle cell fate commitment (GO:0042693)7.34216059
10camera-type eye morphogenesis (GO:0048593)6.87766305
11genitalia morphogenesis (GO:0035112)6.85452985
12cornea development in camera-type eye (GO:0061303)6.82301642
13white fat cell differentiation (GO:0050872)6.75047309
14bicarbonate transport (GO:0015701)6.48712221
15mesonephros development (GO:0001823)6.24573188
16branch elongation of an epithelium (GO:0060602)6.10916052
17myoblast migration (GO:0051451)6.08469079
18extracellular matrix assembly (GO:0085029)5.99343947
19induction of positive chemotaxis (GO:0050930)5.85219383
20kidney morphogenesis (GO:0060993)5.84293969
21positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)5.52175188
22lung secretory cell differentiation (GO:0061140)5.50543111
23keratinocyte proliferation (GO:0043616)5.25277069
24negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.23470475
25regulation of skeletal muscle contraction (GO:0014819)4.87161320
26organ induction (GO:0001759)4.82343545
27embryonic digestive tract morphogenesis (GO:0048557)4.81322919
28cellular sodium ion homeostasis (GO:0006883)4.79118058
29keratan sulfate biosynthetic process (GO:0018146)4.74029040
30axis elongation (GO:0003401)4.68077742
31muscle filament sliding (GO:0030049)4.62315709
32actin-myosin filament sliding (GO:0033275)4.62315709
33morphogenesis of an epithelial fold (GO:0060571)4.60967422
34protein heterotrimerization (GO:0070208)4.55882304
35negative regulation of cell cycle arrest (GO:0071157)4.48716646
36epithelial cell-cell adhesion (GO:0090136)4.47274770
37organ formation (GO:0048645)4.37091331
38sarcoplasmic reticulum calcium ion transport (GO:0070296)4.33096284
39regulation of keratinocyte proliferation (GO:0010837)4.17251315
40smooth muscle cell differentiation (GO:0051145)4.08296243
41positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)4.07131622
42establishment of mitotic spindle orientation (GO:0000132)4.00826404
43regulation of bile acid biosynthetic process (GO:0070857)3.95153691
44plasma membrane repair (GO:0001778)3.94356776
45thyroid gland development (GO:0030878)3.93311415
46extracellular fibril organization (GO:0043206)3.92343570
47peptidyl-proline hydroxylation (GO:0019511)3.91551437
48keratan sulfate metabolic process (GO:0042339)3.90436155
49collagen fibril organization (GO:0030199)3.90106298
50cell migration involved in heart development (GO:0060973)3.88347207
51actin-mediated cell contraction (GO:0070252)3.85931587
52regulation of digestive system process (GO:0044058)3.83967947
53venous blood vessel morphogenesis (GO:0048845)3.82814284
54regulation of cholesterol homeostasis (GO:2000188)3.80862074
55regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.77172607
56cardiac muscle cell proliferation (GO:0060038)3.70056059
57skeletal muscle contraction (GO:0003009)3.69980338
58establishment of spindle orientation (GO:0051294)3.68695523
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.67411301
60mesenchymal cell differentiation (GO:0048762)3.65351020
61prostate gland epithelium morphogenesis (GO:0060740)3.64063181
62complement activation, alternative pathway (GO:0006957)3.63421106
63glomerular filtration (GO:0003094)3.61925216
64ERK1 and ERK2 cascade (GO:0070371)3.61854099
65skeletal muscle fiber development (GO:0048741)3.61708643
66positive regulation of p38MAPK cascade (GO:1900745)3.57308441
67striated muscle cell proliferation (GO:0014855)3.50948710
68muscle cell migration (GO:0014812)3.48779793
69regulation of p38MAPK cascade (GO:1900744)3.46029472
70tissue regeneration (GO:0042246)3.45124829
71fibril organization (GO:0097435)3.39675122
72cellular response to cadmium ion (GO:0071276)3.38870325
73vitamin A metabolic process (GO:0006776)3.38662250
74positive chemotaxis (GO:0050918)3.34876353
75neuronal action potential propagation (GO:0019227)3.34134474
76negative regulation of heart growth (GO:0061117)3.33634168
77negative regulation of cardiac muscle tissue growth (GO:0055022)3.33634168
78establishment of mitotic spindle localization (GO:0040001)3.32854185
79response to leptin (GO:0044321)3.31965469
80protein hydroxylation (GO:0018126)3.30189851
81renal filtration (GO:0097205)3.29676499
82regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.29648458
83peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.28902417
84behavioral response to pain (GO:0048266)3.26568294
85endothelial cell morphogenesis (GO:0001886)3.21156848
86establishment of nucleus localization (GO:0040023)3.15353541
87* skeletal muscle adaptation (GO:0043501)3.13102446
88positive regulation of positive chemotaxis (GO:0050927)3.12106417
894-hydroxyproline metabolic process (GO:0019471)3.11420595
90sulfur compound catabolic process (GO:0044273)3.11088331
91myotube cell development (GO:0014904)3.10764269
92regulation of plasminogen activation (GO:0010755)3.10697514
93hair follicle morphogenesis (GO:0031069)3.08154181
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08122985
95actin filament-based movement (GO:0030048)3.06427898
96branching involved in salivary gland morphogenesis (GO:0060445)3.05513603
97bone trabecula formation (GO:0060346)2.98753159
98regulation of positive chemotaxis (GO:0050926)2.96610337
99collagen metabolic process (GO:0032963)2.95814998
100sequestering of extracellular ligand from receptor (GO:0035581)2.94912401
101barbed-end actin filament capping (GO:0051016)2.94627546
102skin morphogenesis (GO:0043589)2.92190490
103prostaglandin biosynthetic process (GO:0001516)2.91928215
104prostanoid biosynthetic process (GO:0046457)2.91928215
105fluid transport (GO:0042044)2.91132466
106regulation of activin receptor signaling pathway (GO:0032925)2.91127741
107creatine metabolic process (GO:0006600)2.90277833
108growth hormone secretion (GO:0030252)2.90022097
109synaptic vesicle maturation (GO:0016188)2.88232390
110multicellular organismal macromolecule metabolic process (GO:0044259)2.86877226
111positive regulation of Notch signaling pathway (GO:0045747)2.86801125
112regulation of circadian sleep/wake cycle (GO:0042749)2.86332950
113regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.86332950
114regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85921426
115locomotory exploration behavior (GO:0035641)2.84972781
116sodium ion export (GO:0071436)2.84411110
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.84399410
118regulation of complement activation (GO:0030449)2.81223220
119regulation of cell communication by electrical coupling (GO:0010649)2.80940344
120lymph vessel development (GO:0001945)2.80457996
121positive regulation of neutrophil chemotaxis (GO:0090023)2.80120019
122positive regulation of neutrophil migration (GO:1902624)2.80120019
123regulation of fibroblast migration (GO:0010762)2.79812805
124eye morphogenesis (GO:0048592)2.79788069
125collagen catabolic process (GO:0030574)2.79484867
126striated muscle contraction (GO:0006941)2.79204450
127positive regulation of granulocyte chemotaxis (GO:0071624)2.78523761
128glycogen catabolic process (GO:0005980)2.77880582
129muscle cell proliferation (GO:0033002)2.77682804
130dopaminergic neuron differentiation (GO:0071542)2.77658759
131potassium ion import (GO:0010107)2.77234163
132developmental induction (GO:0031128)2.76942995
133positive regulation of steroid biosynthetic process (GO:0010893)2.76638935
134myoblast fusion (GO:0007520)2.76331501
135cellular response to nitric oxide (GO:0071732)2.75858905
136sodium ion homeostasis (GO:0055078)2.74152467
137response to prostaglandin E (GO:0034695)2.73571779
138regulation of organ formation (GO:0003156)2.73558735
139cyclooxygenase pathway (GO:0019371)2.72505215
140cellular potassium ion homeostasis (GO:0030007)2.72008308
141multicellular organismal metabolic process (GO:0044236)2.70646748
142phosphate ion transmembrane transport (GO:0035435)2.67821297
143prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.66760507
144blood circulation (GO:0008015)2.66147209
145negative regulation of muscle hypertrophy (GO:0014741)2.65501978
146cellular response to electrical stimulus (GO:0071257)2.65335448
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65155557
148cell-cell signaling involved in cell fate commitment (GO:0045168)2.65066642
149transepithelial transport (GO:0070633)2.63453132
150polyol transport (GO:0015791)2.63069380
151temperature homeostasis (GO:0001659)2.62821779
152myofibril assembly (GO:0030239)2.62482734
153glutamate secretion (GO:0014047)2.62347336
154multicellular organismal catabolic process (GO:0044243)2.61295539
155metanephric nephron tubule development (GO:0072234)2.60690560
156metanephric tubule development (GO:0072170)2.60690560
157neuromuscular junction development (GO:0007528)2.60406917
158pancreas development (GO:0031016)2.57915107
159positive regulation of small GTPase mediated signal transduction (GO:0051057)2.57651839
160glucan catabolic process (GO:0009251)2.56583994
161regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.55531756
162cytolysis (GO:0019835)2.52403500
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51713906
164regulation of protein activation cascade (GO:2000257)2.50597697
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50019992
166cellular polysaccharide biosynthetic process (GO:0033692)2.48037336
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47661445
168polysaccharide biosynthetic process (GO:0000271)2.47645745
169L-amino acid import (GO:0043092)2.46403016
170neuromuscular synaptic transmission (GO:0007274)2.45235629
171blood vessel maturation (GO:0001955)2.43484458
172regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41449159
173detection of molecule of bacterial origin (GO:0032490)2.41303280
174sarcomere organization (GO:0045214)2.40497318
175regulation of cardiac muscle cell differentiation (GO:2000725)2.40105017
176negative regulation of complement activation (GO:0045916)2.39899688
177positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.39843796
178glycosaminoglycan catabolic process (GO:0006027)2.39650092
179carnitine shuttle (GO:0006853)2.37146885
180regulation of calcium ion transmembrane transport (GO:1903169)2.37027961
181regulation of calcium ion transmembrane transporter activity (GO:1901019)2.37027961
182polysaccharide catabolic process (GO:0000272)2.36184752
183synaptic vesicle docking involved in exocytosis (GO:0016081)2.36095932
184muscle contraction (GO:0006936)2.35343561
185oxygen transport (GO:0015671)2.35178347
186ovulation cycle (GO:0042698)2.33821409
187glycosaminoglycan biosynthetic process (GO:0006024)2.32755734
188glomerular basement membrane development (GO:0032836)14.5655566
189mesenchymal-epithelial cell signaling (GO:0060638)12.0117442
190otic vesicle formation (GO:0030916)11.6475845
191regulation of branching involved in salivary gland morphogenesis (GO:0060693)10.3948746
192radial glial cell differentiation (GO:0060019)10.2416648
193lateral sprouting from an epithelium (GO:0060601)10.1652149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.68976433
2HIF1A_21447827_ChIP-Seq_MCF-7_Human2.79417281
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.74331060
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44143577
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37572627
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37572627
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32528114
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27005494
9DROSHA_22980978_ChIP-Seq_HELA_Human2.25142475
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23862134
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19500630
12AR_21572438_ChIP-Seq_LNCaP_Human2.18705295
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16385761
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13763791
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11711999
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07760748
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04006445
18STAT3_19079543_ChIP-ChIP_MESCs_Mouse2.01536817
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99713224
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.98621694
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98275351
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90303415
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89952841
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.89844024
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86149204
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.83929277
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83767566
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.80908002
29PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.79347566
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.77514015
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.73768190
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.71901445
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71324922
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71250435
35* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67946484
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55840766
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53677310
38* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47621075
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46191833
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43978399
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40094429
42CJUN_26792858_Chip-Seq_BT549_Human1.39290802
43GBX2_23144817_ChIP-Seq_PC3_Human1.39264672
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.39106855
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.37990999
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.35287869
47CLOCK_20551151_ChIP-Seq_293T_Human1.32749512
48KDM2B_26808549_Chip-Seq_K562_Human1.31505886
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.31493600
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.31146001
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29974066
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29803173
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29318193
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.28916071
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28368267
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25636113
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.24976554
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23197847
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23171277
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.23086238
61* RXR_22158963_ChIP-Seq_LIVER_Mouse1.22292867
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20155183
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19083720
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17888389
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.16516234
66TP53_16413492_ChIP-PET_HCT116_Human1.15882654
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.15689320
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.15689320
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15283501
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12533393
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09892602
72STAT1_20625510_ChIP-Seq_HELA_Human1.08730234
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06613098
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06613098
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06452397
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06210345
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.06028505
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05658146
79TP53_18474530_ChIP-ChIP_U2OS_Human1.05193103
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04951932
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03954036
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03915261
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02815101
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.02813227
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02710589
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.02533230
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02467121
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02436285
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.01621811
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01431895
91MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01124730
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00930030
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00842844
94LXR_22292898_ChIP-Seq_THP-1_Human1.00310021
95* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98854170
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98360343
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.98345818
98RXR_22108803_ChIP-Seq_LS180_Human0.97419878
99AR_19668381_ChIP-Seq_PC3_Human0.97316922
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.96936099
101SMAD4_21799915_ChIP-Seq_A2780_Human0.96198377
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.95535743
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94736185
104* CTCF_27219007_Chip-Seq_Bcells_Human0.94699736
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.94259425
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94115081
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93792373
108AR_25329375_ChIP-Seq_VCAP_Human0.93153684
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.92838919
110ZNF263_19887448_ChIP-Seq_K562_Human0.92576920
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91661081
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.90734065
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90031141
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89915963
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89682382
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89056052
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88798142
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87278844
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86911419
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86722605
121AHR_22903824_ChIP-Seq_MCF-7_Human0.86563227
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86353184
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85526396
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85306936
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.84526449
126EOMES_21245162_ChIP-Seq_HESCs_Human0.84507900
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.84033412
128RING1B_27294783_Chip-Seq_NPCs_Mouse0.83848458
129REST_21632747_ChIP-Seq_MESCs_Mouse0.82953869
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82036871
131KDM2B_26808549_Chip-Seq_DND41_Human0.81617930
132BCAT_22108803_ChIP-Seq_LS180_Human0.80775885
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80669860
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80645944
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80389419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.50112181
2MP0002102_abnormal_ear_morphology6.92423458
3MP0005275_abnormal_skin_tensile6.70406216
4MP0008438_abnormal_cutaneous_collagen5.80001609
5MP0000751_myopathy4.66399517
6MP0002132_abnormal_respiratory_system4.03259451
7MP0001661_extended_life_span4.02603769
8MP0005248_abnormal_Harderian_gland3.93214001
9MP0004145_abnormal_muscle_electrophysio3.83347575
10MP0002108_abnormal_muscle_morphology3.35434892
11MP0000749_muscle_degeneration3.13825503
12MP0003646_muscle_fatigue3.04730438
13MP0000747_muscle_weakness2.95804147
14MP0002277_abnormal_respiratory_mucosa2.50188631
15MP0004859_abnormal_synaptic_plasticity2.47102284
16MP0004742_abnormal_vestibular_system2.42763054
17MP0005369_muscle_phenotype2.39566368
18MP0001958_emphysema2.25048055
19MP0002106_abnormal_muscle_physiology2.23756546
20MP0003705_abnormal_hypodermis_morpholog2.08371463
21MP0010030_abnormal_orbit_morphology2.06843266
22MP0002909_abnormal_adrenal_gland2.04694237
23MP0000750_abnormal_muscle_regeneration2.01495885
24MP0003878_abnormal_ear_physiology10.0125227
25MP0005377_hearing/vestibular/ear_phenot10.0125227
26MP0000759_abnormal_skeletal_muscle1.96472020
27MP0004087_abnormal_muscle_fiber1.93792746
28MP0005508_abnormal_skeleton_morphology1.87670162
29MP0004036_abnormal_muscle_relaxation1.82477817
30MP0004130_abnormal_muscle_cell1.79964892
31MP0002837_dystrophic_cardiac_calcinosis1.71007648
32MP0006072_abnormal_retinal_apoptosis1.69513029
33MP0004270_analgesia1.68765323
34MP0002269_muscular_atrophy1.63614720
35MP0002060_abnormal_skin_morphology1.63521916
36MP0001756_abnormal_urination1.60079400
37MP0003279_aneurysm1.51821790
38MP0009780_abnormal_chondrocyte_physiolo1.48496283
39MP0004272_abnormal_basement_membrane1.45237160
40MP0005620_abnormal_muscle_contractility1.43516595
41MP0004858_abnormal_nervous_system1.43170714
42MP0002090_abnormal_vision1.41202433
43MP0000566_synostosis1.39536135
44MP0003075_altered_response_to1.37977437
45MP0001502_abnormal_circadian_rhythm1.36881302
46MP0005193_abnormal_anterior_eye1.32334254
47MP0000013_abnormal_adipose_tissue1.30352164
48MP0004233_abnormal_muscle_weight1.28852685
49MP0000733_abnormal_muscle_development1.26015455
50MP0006054_spinal_hemorrhage1.24192551
51MP0003011_delayed_dark_adaptation1.22201185
52MP0002009_preneoplasia1.22198095
53MP0005670_abnormal_white_adipose1.16580775
54MP0003635_abnormal_synaptic_transmissio1.16011254
55MP0004185_abnormal_adipocyte_glucose1.11053601
56MP0008569_lethality_at_weaning1.09540451
57MP0005330_cardiomyopathy1.09311631
58MP0003938_abnormal_ear_development1.06448619
59MP0002295_abnormal_pulmonary_circulatio1.06311161
60MP0009250_abnormal_appendicular_skeleto1.06256405
61MP0004043_abnormal_pH_regulation1.05638588
62MP0003879_abnormal_hair_cell1.05038755
63MP0000026_abnormal_inner_ear1.04754039
64MP0001299_abnormal_eye_distance/1.04235164
65MP0002796_impaired_skin_barrier1.03592786
66MP0002933_joint_inflammation0.97570358
67MP0000613_abnormal_salivary_gland0.92798686
68MP0005390_skeleton_phenotype0.92665128
69MP0003045_fibrosis0.89855659
70MP0010368_abnormal_lymphatic_system0.88463716
71MP0003303_peritoneal_inflammation0.85817558
72MP0003567_abnormal_fetal_cardiomyocyte0.82397626
73MP0004484_altered_response_of0.80960109
74MP0009384_cardiac_valve_regurgitation0.80913105
75MP0004215_abnormal_myocardial_fiber0.79981640
76MP0000163_abnormal_cartilage_morphology0.79717079
77MP0002089_abnormal_postnatal_growth/wei0.78230250
78MP0004084_abnormal_cardiac_muscle0.77551147
79MP0001501_abnormal_sleep_pattern0.77099578
80MP0009046_muscle_twitch0.76846460
81MP0002697_abnormal_eye_size0.76599375
82MP0005197_abnormal_uvea_morphology0.76019918
83MP0005171_absent_coat_pigmentation0.75143984
84MP0003690_abnormal_glial_cell0.75069539
85MP0001963_abnormal_hearing_physiology0.74607581
86MP0002896_abnormal_bone_mineralization0.74487521
87MP0002332_abnormal_exercise_endurance0.73186776
88MP0003329_amyloid_beta_deposits0.72678931
89MP0000762_abnormal_tongue_morphology0.72420593
90MP0005332_abnormal_amino_acid0.72199832
91MP0002876_abnormal_thyroid_physiology0.72062229
92MP0005076_abnormal_cell_differentiation0.71933827
93MP0005666_abnormal_adipose_tissue0.71141581
94MP0009643_abnormal_urine_homeostasis0.71058962
95MP0004134_abnormal_chest_morphology0.70846359
96MP0009745_abnormal_behavioral_response0.70817242
97MP0002006_tumorigenesis0.70662255
98MP0002064_seizures0.70526670
99MP0003385_abnormal_body_wall0.70170897
100MP0000579_abnormal_nail_morphology0.69853323
101MP0010771_integument_phenotype0.69738425
102MP0003115_abnormal_respiratory_system0.69170768
103MP0002115_abnormal_skeleton_extremities0.69100430
104MP0000230_abnormal_systemic_arterial0.68892446
105MP0003941_abnormal_skin_development0.68334420
106MP0002063_abnormal_learning/memory/cond0.68323138
107MP0002166_altered_tumor_susceptibility0.68065860
108MP0002971_abnormal_brown_adipose0.67516435
109MP0005375_adipose_tissue_phenotype0.66920001
110MP0008961_abnormal_basal_metabolism0.66612120
111MP0000343_altered_response_to0.65742851
112MP0004510_myositis0.65209275
113MP0005165_increased_susceptibility_to0.64330345
114MP0002972_abnormal_cardiac_muscle0.63838054
115MP0003283_abnormal_digestive_organ0.61946252
116MP0005623_abnormal_meninges_morphology0.61578216
117MP0010630_abnormal_cardiac_muscle0.61508131
118MP0000767_abnormal_smooth_muscle0.61482782
119MP0002734_abnormal_mechanical_nocicepti0.61206066
120MP0003633_abnormal_nervous_system0.60852644
121MP0001243_abnormal_dermal_layer0.57972536
122MP0003119_abnormal_digestive_system0.57541897
123MP0002272_abnormal_nervous_system0.56605733
124MP0002136_abnormal_kidney_physiology0.56559001
125MP0005253_abnormal_eye_physiology0.56467915
126MP0005388_respiratory_system_phenotype0.56341253
127MP0002133_abnormal_respiratory_system0.56341253
128MP0000003_abnormal_adipose_tissue0.56123139
129MP0005365_abnormal_bile_salt0.54521659
130MP0003091_abnormal_cell_migration0.53621415
131MP0001879_abnormal_lymphatic_vessel0.53557927
132MP0002932_abnormal_joint_morphology0.51338307
133MP0001177_atelectasis0.51333511
134MP0003937_abnormal_limbs/digits/tail_de0.50542129
135MP0000372_irregular_coat_pigmentation0.50428264
136MP0004085_abnormal_heartbeat0.50178519
137MP0001486_abnormal_startle_reflex0.49722169
138MP0000534_abnormal_ureter_morphology0.49587601
139MP0003959_abnormal_lean_body0.49544515
140MP0001544_abnormal_cardiovascular_syste0.49296985
141MP0005385_cardiovascular_system_phenoty0.49296985
142MP0005023_abnormal_wound_healing0.48811291
143MP0002184_abnormal_innervation0.48781636
144MP0005391_vision/eye_phenotype0.48245836
145MP0004885_abnormal_endolymph0.48145101
146MP0005451_abnormal_body_composition0.46582825
147MP0009115_abnormal_fat_cell0.45385606
148MP0001485_abnormal_pinna_reflex0.45347193
149MP0000639_abnormal_adrenal_gland0.38675656
150MP0000569_abnormal_digit_pigmentation0.36206364
151MP0002135_abnormal_kidney_morphology0.35854452
152MP0002177_abnormal_outer_ear0.35060129
153MP0001614_abnormal_blood_vessel0.34875182
154MP0002092_abnormal_eye_morphology0.34749447
155MP0002128_abnormal_blood_circulation0.33940218
156MP0003942_abnormal_urinary_system0.32783628
157MP0000627_abnormal_mammary_gland0.32768332
158MP0006036_abnormal_mitochondrial_physio0.32060109
159MP0003828_pulmonary_edema0.31730418
160MP0005584_abnormal_enzyme/coenzyme_acti0.31589721
161MP0005379_endocrine/exocrine_gland_phen0.31346324
162MP0005535_abnormal_body_temperature0.31317411
163MP0010329_abnormal_lipoprotein_level0.30924072

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)9.39838405
2Aplasia involving bones of the extremities (HP:0009825)8.66337770
3Aplasia involving bones of the upper limbs (HP:0009823)8.66337770
4Aplasia of the phalanges of the hand (HP:0009802)8.66337770
5Partial duplication of thumb phalanx (HP:0009944)8.02041109
6Partial duplication of the phalanx of hand (HP:0009999)7.54613208
7Type 1 muscle fiber predominance (HP:0003803)7.40286961
8Nephritis (HP:0000123)6.74186994
9Alacrima (HP:0000522)6.44394005
10Increased connective tissue (HP:0009025)6.36683364
11Recurrent corneal erosions (HP:0000495)5.94884714
12Abnormality of incisor morphology (HP:0011063)5.92096590
13Exercise-induced myalgia (HP:0003738)5.84392262
14Muscle fiber splitting (HP:0003555)5.81042056
15Protrusio acetabuli (HP:0003179)5.67556401
16Muscle fiber inclusion bodies (HP:0100299)5.66221526
17Conical tooth (HP:0000698)5.65612480
18Decreased lacrimation (HP:0000633)5.43662294
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.33463415
20Round ear (HP:0100830)5.26902256
21Corneal erosion (HP:0200020)5.17551959
22Exercise-induced muscle cramps (HP:0003710)5.10922540
23Nemaline bodies (HP:0003798)4.92085284
24Nasolacrimal duct obstruction (HP:0000579)4.74925219
25Mixed hearing impairment (HP:0000410)4.74523336
26Flat cornea (HP:0007720)4.69924408
27Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.58122354
28Increased variability in muscle fiber diameter (HP:0003557)4.54632222
29Abnormality of skeletal muscle fiber size (HP:0012084)4.39268687
30Xerostomia (HP:0000217)4.36463812
31Broad metatarsal (HP:0001783)4.32952826
32Slender build (HP:0001533)4.27678995
33Abnormality of the salivary glands (HP:0010286)4.24632100
34Muscle hypertrophy of the lower extremities (HP:0008968)4.22345668
35Ankle contracture (HP:0006466)4.20518181
36Corneal dystrophy (HP:0001131)4.15321789
37Duplication of thumb phalanx (HP:0009942)4.05267293
38Aplasia of the musculature (HP:0100854)4.02594026
39Distal arthrogryposis (HP:0005684)3.95837419
40Calf muscle hypertrophy (HP:0008981)3.88858167
41Abnormality of the lacrimal duct (HP:0011481)3.81474758
42Abnormality of permanent molar morphology (HP:0011071)3.72674114
43Abnormality of the dental root (HP:0006486)3.72674114
44Taurodontia (HP:0000679)3.72674114
45Spinal rigidity (HP:0003306)3.71610481
46Concave nail (HP:0001598)3.71207049
47Hyperkalemia (HP:0002153)3.70554878
48Ulnar deviation of the wrist (HP:0003049)3.69945562
49Difficulty running (HP:0009046)3.65989038
50Broad hallux (HP:0010055)3.64274014
51Polar cataract (HP:0010696)3.62866395
52Follicular hyperkeratosis (HP:0007502)3.59341199
53Abnormality of the nasolacrimal system (HP:0000614)3.55277629
54Abnormality of molar morphology (HP:0011070)3.54653917
55Abnormality of molar (HP:0011077)3.54653917
56Hyporeflexia of lower limbs (HP:0002600)3.53372960
57Myopathic facies (HP:0002058)3.49984982
58Abnormality of the dental pulp (HP:0006479)3.38229745
59Mildly elevated creatine phosphokinase (HP:0008180)3.37105135
60Abnormality of the musculature of the hand (HP:0001421)3.35148109
61Premature rupture of membranes (HP:0001788)3.30864770
62Calcaneovalgus deformity (HP:0001848)3.27690190
63Muscle stiffness (HP:0003552)3.25373824
64Myotonia (HP:0002486)3.22394909
65EMG: myopathic abnormalities (HP:0003458)3.16871133
66Myoglobinuria (HP:0002913)3.16201099
67Deformed tarsal bones (HP:0008119)3.11383151
68Wrist flexion contracture (HP:0001239)3.04331036
69Broad toe (HP:0001837)3.01794434
70Soft skin (HP:0000977)2.97490244
71Abnormality of the calf musculature (HP:0001430)2.96791399
72Stage 5 chronic kidney disease (HP:0003774)2.94921453
73Striae distensae (HP:0001065)2.93385225
74Hypoplasia of the ulna (HP:0003022)2.82174180
75Absent phalangeal crease (HP:0006109)2.81914201
76Heterochromia iridis (HP:0001100)2.81762511
77Preaxial foot polydactyly (HP:0001841)2.73317638
78Complement deficiency (HP:0004431)2.71555073
79Achilles tendon contracture (HP:0001771)2.61389243
80Hematuria (HP:0000790)2.58546781
81Proximal amyotrophy (HP:0007126)2.58393863
82Bronchomalacia (HP:0002780)2.57638370
83Rectal prolapse (HP:0002035)2.56569931
84Abnormality of the antihelix (HP:0009738)2.55658932
85Mitral valve prolapse (HP:0001634)2.53224333
86Shallow orbits (HP:0000586)2.50510696
87Limb-girdle muscle weakness (HP:0003325)2.49138364
88Abnormality of the incisor (HP:0000676)2.46473443
89Absent radius (HP:0003974)2.41175635
90Cerebral aneurysm (HP:0004944)2.40626943
91Difficulty climbing stairs (HP:0003551)2.37147025
92Abnormality of the Achilles tendon (HP:0005109)2.36418467
93Cupped ear (HP:0000378)2.34761986
94Amyloidosis (HP:0011034)2.33025839
95Aortic dissection (HP:0002647)2.32332614
96Frequent falls (HP:0002359)2.31854640
97Abnormal finger flexion creases (HP:0006143)2.30417800
98Bladder diverticulum (HP:0000015)2.29884046
99Increased corneal curvature (HP:0100692)2.29512768
100Keratoconus (HP:0000563)2.29512768
101Overfolded helix (HP:0000396)2.29343710
102Hyponatremia (HP:0002902)2.29177348
103Neonatal short-limb short stature (HP:0008921)2.27197555
104Absent forearm bone (HP:0003953)2.25839683
105Aplasia involving forearm bones (HP:0009822)2.25839683
106Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.25241511
107Abnormality of the radial head (HP:0003995)2.23648663
108Exostoses (HP:0100777)2.21356353
109Ridged nail (HP:0001807)2.19800133
110Hyperextensible skin (HP:0000974)2.19028025
111Recurrent gram-negative bacterial infections (HP:0005420)2.18862713
112Abnormally folded helix (HP:0008544)2.18032933
113Cubitus valgus (HP:0002967)2.17188582
114Hypoplastic ischia (HP:0003175)2.16544837
115Bulbar palsy (HP:0001283)2.16224456
116Dilatation of the ascending aorta (HP:0005111)2.14851220
117Aplasia/Hypoplasia of the ulna (HP:0006495)2.13556305
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12017856
119Aplasia/Hypoplasia of the earlobes (HP:0009906)2.11813563
120Muscular dystrophy (HP:0003560)2.07944335
121Neck muscle weakness (HP:0000467)2.06289271
122Hypoplasia of the radius (HP:0002984)2.05398825
123Abnormality of the middle phalanges of the hand (HP:0009833)2.05257453
124Atrophic scars (HP:0001075)2.03724816
125Aplasia/Hypoplasia involving the musculature (HP:0001460)2.02981230
126Narrow nasal bridge (HP:0000446)2.02909305
127Abnormality of sodium homeostasis (HP:0010931)2.00647641
128Hypoventilation (HP:0002791)2.00075860
129Turricephaly (HP:0000262)1.98027104
130Sudden death (HP:0001699)1.97856151
131Tarsal synostosis (HP:0008368)1.93565516
132Vertebral compression fractures (HP:0002953)1.92970707
133Nephrotic syndrome (HP:0000100)1.91165491
134Abnormality of complement system (HP:0005339)1.89544522
135Distal lower limb muscle weakness (HP:0009053)1.89524618
136Bell-shaped thorax (HP:0001591)1.88835129
137Abnormality of the ischium (HP:0003174)1.88680104
138Abnormality of the left ventricular outflow tract (HP:0011103)1.88594101
139Subaortic stenosis (HP:0001682)1.88594101
140Generalized amyotrophy (HP:0003700)1.88500995
141Arterial tortuosity (HP:0005116)1.87796562
142Rhabdomyolysis (HP:0003201)1.86463058
143Cervical subluxation (HP:0003308)1.86354334
144Synostosis involving the elbow (HP:0003938)1.85449663
145Humeroradial synostosis (HP:0003041)1.85449663
146Fragile skin (HP:0001030)1.84609040
147Hypophosphatemia (HP:0002148)1.84480975
148Congenital glaucoma (HP:0001087)1.83955710
149Genu recurvatum (HP:0002816)1.83643055
150Hip contracture (HP:0003273)1.83037112
151Pulmonary artery stenosis (HP:0004415)1.82507606
152Malignant hyperthermia (HP:0002047)1.82315482
153Pterygium (HP:0001059)1.82279672
154Hyperactive renin-angiotensin system (HP:0000841)1.81707841
155Asymmetric septal hypertrophy (HP:0001670)1.81297487
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80822648
157Joint laxity (HP:0001388)1.80494341
158Vascular tortuosity (HP:0004948)1.79908351
159Focal motor seizures (HP:0011153)1.77971321
160Hypoplasia of the iris (HP:0007676)1.77322550
161Shoulder girdle muscle weakness (HP:0003547)1.76244796
162Abnormality of the calcaneus (HP:0008364)1.76014943
163Biconcave vertebral bodies (HP:0004586)1.75723051
164Abnormality of the musculature of the pelvis (HP:0001469)1.73528463
165Abnormality of the hip-girdle musculature (HP:0001445)1.73528463
166Synostosis involving bones of the lower limbs (HP:0009138)1.73391399
167Synostosis involving bones of the feet (HP:0009140)1.73391399
168Vascular calcification (HP:0004934)1.72853357
169Abnormality of primary teeth (HP:0006481)1.72594037
170Pelvic girdle muscle weakness (HP:0003749)1.72556631
171Hypoplasia of dental enamel (HP:0006297)1.71117071
172Anterior segment dysgenesis (HP:0007700)1.70487912
173Limited hip movement (HP:0008800)1.69667373
174Limited elbow extension (HP:0001377)1.68729626
175Aplasia/Hypoplasia of the lens (HP:0008063)1.67944170
176Nonprogressive disorder (HP:0003680)1.67938183
177Hypodontia (HP:0000668)1.67246558
178Distal lower limb amyotrophy (HP:0008944)1.66273167
179Microdontia (HP:0000691)1.65756743
180Aortic aneurysm (HP:0004942)1.64956489
181Cardiovascular calcification (HP:0011915)1.62568668
182Postural instability (HP:0002172)1.61152154
183Bilateral sensorineural hearing impairment (HP:0008619)1.54258065
184Nephrocalcinosis (HP:0000121)1.53962052
185Renal tubular acidosis (HP:0001947)1.52119408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.96989405
2PHKG23.83189166
3PHKG13.83189166
4TTN3.79951817
5TRPM73.17206414
6GRK72.90454484
7CAMK2B2.87990540
8TRIB32.83428119
9DDR22.56651144
10RIPK12.53360690
11RIPK42.33098100
12NME12.09888013
13ARAF2.08440581
14MAP3K72.06468091
15DAPK22.05250064
16MAP3K91.92652856
17DMPK1.76748474
18PRKD31.75681331
19NTRK31.69375076
20PINK11.69210651
21MAPK151.69180414
22NLK1.62066915
23MAP2K41.55992675
24ERN11.54373236
25MAPK71.47604583
26PDGFRA1.47547116
27KSR21.45063873
28SIK11.43128321
29PIK3CG1.41487544
30MST1R1.40397727
31EPHA41.35658537
32PAK61.27229432
33MAP2K31.24322332
34TAOK11.20633077
35EPHB11.17423677
36MAP3K61.15796966
37MAP3K41.13138250
38MAPK121.12409542
39PRKCH1.12347491
40PIK3CA1.08527206
41PDK41.08269014
42PDK31.08269014
43AKT21.08262089
44LATS21.07817871
45MAPK41.04409057
46FER1.04020952
47GRK11.03819811
48STK381.02075943
49MAP3K30.98130554
50STK100.97256630
51PDK20.96013132
52MKNK10.95247033
53MUSK0.94668853
54NTRK20.94580494
55ADRBK10.92655517
56FGFR40.92139838
57NTRK10.89326541
58ICK0.88156138
59BMX0.87817522
60EPHA30.87563044
61PAK40.83682025
62LMTK20.82491787
63TBK10.81905933
64NEK10.81239361
65IRAK10.80503609
66PTK2B0.80014908
67MINK10.79549794
68EIF2AK20.79419813
69RET0.78540451
70CSK0.78368298
71MYLK0.77360145
72PAK30.77279550
73MAPKAPK30.77182873
74CAMKK10.76750518
75YES10.75784227
76LATS10.75371688
77FGFR20.74573185
78MAP3K20.72514005
79RPS6KL10.71744215
80RPS6KC10.71744215
81MAPKAPK50.71713925
82TGFBR20.71523057
83PRKD10.69768731
84FGFR10.68659029
85MAP3K10.68276432
86TSSK60.67825967
87SGK20.67700794
88CDK50.66924999
89TIE10.62683291
90NEK60.62027541
91JAK20.61974059
92RPS6KA60.59977358
93TESK10.58579767
94GRK50.58143164
95SGK30.57958866
96TYRO30.55286679
97PKN20.55283080
98PRKAA20.55155717
99PTK60.53654426
100FGFR30.53318915
101TNIK0.53132840
102MAP2K10.52361993
103CAMK1G0.51961873
104IRAK20.51661186
105MTOR0.51121979
106CAMK2G0.51098491
107PDGFRB0.50291641
108CAMK10.49206707
109PRKD20.48893030
110STK110.48583836
111KSR10.47840585
112SGK4940.47426853
113SGK2230.47426853
114SGK10.47294085
115RAF10.47288512
116MARK20.46890097
117PDPK10.46086270
118IKBKE0.45357917
119ROCK10.44827986
120PRKAA10.44827110
121MAP3K130.44804878
122JAK10.44795577
123TYK20.44462832
124PAK20.43934637
125FLT30.43137249
126MAP2K60.42677602
127GSK3A0.42244589
128PKN10.41448355
129PDK10.40234786
130MAP2K20.40052782
131ERBB40.39244682
132RPS6KA30.39079941
133MOS0.38936440
134STK38L0.38762946
135MET0.38615869
136UHMK10.37689541
137INSR0.35437728
138MAPK30.34631184
139PRKACA0.33814299
140ABL20.29969125
141EEF2K0.28781076
142MAP3K140.28247534
143ROCK20.27918422
144BRAF0.26937442
145HIPK20.25021572
146PRKACG0.22253211
147NEK90.21122404

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.68260967
2ECM-receptor interaction_Homo sapiens_hsa045122.95017710
3Small cell lung cancer_Homo sapiens_hsa052222.37117335
4Melanoma_Homo sapiens_hsa052182.25535625
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.15446176
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08720727
7Dilated cardiomyopathy_Homo sapiens_hsa054142.06849138
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99681791
9Protein digestion and absorption_Homo sapiens_hsa049741.86404825
10Focal adhesion_Homo sapiens_hsa045101.79210856
11Malaria_Homo sapiens_hsa051441.71778715
12Prion diseases_Homo sapiens_hsa050201.70104784
13Gastric acid secretion_Homo sapiens_hsa049711.67043300
14Pyruvate metabolism_Homo sapiens_hsa006201.66352081
15Oxytocin signaling pathway_Homo sapiens_hsa049211.64891785
16Tryptophan metabolism_Homo sapiens_hsa003801.63710145
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60319472
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57652980
19GnRH signaling pathway_Homo sapiens_hsa049121.49460977
20Pentose phosphate pathway_Homo sapiens_hsa000301.44228002
21Circadian entrainment_Homo sapiens_hsa047131.42881616
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42710818
23Calcium signaling pathway_Homo sapiens_hsa040201.41251605
24Cardiac muscle contraction_Homo sapiens_hsa042601.37432081
25Carbon metabolism_Homo sapiens_hsa012001.36715529
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34069124
27Circadian rhythm_Homo sapiens_hsa047101.30860930
28Long-term potentiation_Homo sapiens_hsa047201.29130196
29Salivary secretion_Homo sapiens_hsa049701.27047998
30Lysine degradation_Homo sapiens_hsa003101.26508643
31GABAergic synapse_Homo sapiens_hsa047271.25779751
32Insulin secretion_Homo sapiens_hsa049111.25669395
33Histidine metabolism_Homo sapiens_hsa003401.20981258
34Insulin resistance_Homo sapiens_hsa049311.19430960
35Renin secretion_Homo sapiens_hsa049241.17612243
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17016308
37Type II diabetes mellitus_Homo sapiens_hsa049301.16501967
38Glutamatergic synapse_Homo sapiens_hsa047241.16215517
39Estrogen signaling pathway_Homo sapiens_hsa049151.15936335
40Nicotine addiction_Homo sapiens_hsa050331.15661621
41Olfactory transduction_Homo sapiens_hsa047401.15586073
42Amphetamine addiction_Homo sapiens_hsa050311.15444602
43PPAR signaling pathway_Homo sapiens_hsa033201.15420085
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.15392759
45Fructose and mannose metabolism_Homo sapiens_hsa000511.14520177
46Glucagon signaling pathway_Homo sapiens_hsa049221.13908767
47Inositol phosphate metabolism_Homo sapiens_hsa005621.13596060
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13560979
49Insulin signaling pathway_Homo sapiens_hsa049101.12272820
50Pathways in cancer_Homo sapiens_hsa052001.11641124
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09667229
52Dorso-ventral axis formation_Homo sapiens_hsa043201.08193532
53Amoebiasis_Homo sapiens_hsa051461.07925025
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07360797
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06417152
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.04200095
57Cholinergic synapse_Homo sapiens_hsa047251.02348298
58beta-Alanine metabolism_Homo sapiens_hsa004101.01870641
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01009541
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00446956
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99716638
62Synaptic vesicle cycle_Homo sapiens_hsa047210.98796766
63Melanogenesis_Homo sapiens_hsa049160.95711505
64Biosynthesis of amino acids_Homo sapiens_hsa012300.95140695
65Glioma_Homo sapiens_hsa052140.94697589
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94691909
67Fatty acid metabolism_Homo sapiens_hsa012120.92359841
68Phenylalanine metabolism_Homo sapiens_hsa003600.91166072
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89248821
70Dopaminergic synapse_Homo sapiens_hsa047280.85352517
71Long-term depression_Homo sapiens_hsa047300.85082827
72MAPK signaling pathway_Homo sapiens_hsa040100.84412343
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84109281
74cAMP signaling pathway_Homo sapiens_hsa040240.83426448
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81742059
76Morphine addiction_Homo sapiens_hsa050320.81646702
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81046602
78Galactose metabolism_Homo sapiens_hsa000520.80066913
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79392347
80Arachidonic acid metabolism_Homo sapiens_hsa005900.78608004
81Ras signaling pathway_Homo sapiens_hsa040140.78589630
82VEGF signaling pathway_Homo sapiens_hsa043700.78389810
83Fatty acid biosynthesis_Homo sapiens_hsa000610.77355588
84Arginine biosynthesis_Homo sapiens_hsa002200.76987442
85Bile secretion_Homo sapiens_hsa049760.76540446
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76391251
87Starch and sucrose metabolism_Homo sapiens_hsa005000.76067273
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74959181
89Proteoglycans in cancer_Homo sapiens_hsa052050.74339691
90Gap junction_Homo sapiens_hsa045400.72283155
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68682659
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.67994646
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64890010
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64540495
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.64365617
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63792088
97Tight junction_Homo sapiens_hsa045300.62733722
98Arginine and proline metabolism_Homo sapiens_hsa003300.62664957
99Platelet activation_Homo sapiens_hsa046110.62233727
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61783895
101Cocaine addiction_Homo sapiens_hsa050300.60477326
102Complement and coagulation cascades_Homo sapiens_hsa046100.59961447
103Axon guidance_Homo sapiens_hsa043600.59173251
104AMPK signaling pathway_Homo sapiens_hsa041520.58197852
105Hedgehog signaling pathway_Homo sapiens_hsa043400.56152524
106Pancreatic secretion_Homo sapiens_hsa049720.55786280
107TGF-beta signaling pathway_Homo sapiens_hsa043500.55175031
108Fatty acid elongation_Homo sapiens_hsa000620.53562061
109Vitamin B6 metabolism_Homo sapiens_hsa007500.53541542
110Choline metabolism in cancer_Homo sapiens_hsa052310.53429535
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53199417
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52847940
113Tyrosine metabolism_Homo sapiens_hsa003500.52002474
114ErbB signaling pathway_Homo sapiens_hsa040120.51932450
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.51566310
116mTOR signaling pathway_Homo sapiens_hsa041500.50748244
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49925967
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48944778
119Rap1 signaling pathway_Homo sapiens_hsa040150.48207348
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48155149
121Bladder cancer_Homo sapiens_hsa052190.47513009
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46557399
123Propanoate metabolism_Homo sapiens_hsa006400.45868643
124Basal cell carcinoma_Homo sapiens_hsa052170.45041287
125Wnt signaling pathway_Homo sapiens_hsa043100.44775570
126HIF-1 signaling pathway_Homo sapiens_hsa040660.44645724
127Adherens junction_Homo sapiens_hsa045200.44626631
128Renal cell carcinoma_Homo sapiens_hsa052110.43836306
129Ovarian steroidogenesis_Homo sapiens_hsa049130.43781785
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43534029
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.43189619
132Fatty acid degradation_Homo sapiens_hsa000710.42680782
133Thyroid hormone synthesis_Homo sapiens_hsa049180.42552113
134Serotonergic synapse_Homo sapiens_hsa047260.42130193
135Glycerolipid metabolism_Homo sapiens_hsa005610.41864035
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39213258
137Alzheimers disease_Homo sapiens_hsa050100.38392948
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37727714
139Parkinsons disease_Homo sapiens_hsa050120.35547214
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.33552561
141ABC transporters_Homo sapiens_hsa020100.31995442
142Oxidative phosphorylation_Homo sapiens_hsa001900.22286297
143Glutathione metabolism_Homo sapiens_hsa004800.18091358
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17698233
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16223583

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