MYOCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.19995806
2myofibril assembly (GO:0030239)8.76990661
3actin-myosin filament sliding (GO:0033275)8.16654750
4muscle filament sliding (GO:0030049)8.16654750
5cardiac muscle contraction (GO:0060048)7.51809820
6cardiac muscle tissue morphogenesis (GO:0055008)7.51485534
7cardiac muscle cell development (GO:0055013)7.41929578
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.15018262
9actin-mediated cell contraction (GO:0070252)7.04172475
10cardiac cell development (GO:0055006)7.00542447
11ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.94867696
12cardiac muscle hypertrophy (GO:0003300)6.89167554
13muscle tissue morphogenesis (GO:0060415)6.73200728
14adult heart development (GO:0007512)6.60694080
15negative regulation of potassium ion transmembrane transport (GO:1901380)6.56128157
16striated muscle hypertrophy (GO:0014897)6.48068136
17actomyosin structure organization (GO:0031032)6.40070502
18regulation of relaxation of muscle (GO:1901077)6.27033811
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.24140218
20heart contraction (GO:0060047)6.17532350
21heart process (GO:0003015)6.17532350
22regulation of actin filament-based movement (GO:1903115)5.96052736
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.87774193
24muscle hypertrophy (GO:0014896)5.80471855
25regulation of cardioblast differentiation (GO:0051890)5.73465866
26regulation of sarcomere organization (GO:0060297)5.65284341
27regulation of the force of heart contraction (GO:0002026)5.60236791
28bundle of His cell to Purkinje myocyte communication (GO:0086069)5.52606338
29striated muscle contraction (GO:0006941)5.52144813
30sequestering of extracellular ligand from receptor (GO:0035581)5.51483353
31ventricular cardiac muscle cell action potential (GO:0086005)5.47901868
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.45482326
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.44468930
34heart trabecula formation (GO:0060347)5.39304440
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.30682409
36actin filament-based movement (GO:0030048)5.28810311
37tricarboxylic acid cycle (GO:0006099)5.27413904
38regulation of striated muscle contraction (GO:0006942)5.08420894
39negative regulation of hormone biosynthetic process (GO:0032353)5.04318759
40regulation of skeletal muscle contraction (GO:0014819)4.98527098
41atrioventricular valve morphogenesis (GO:0003181)4.91214601
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.68405747
43ventricular cardiac muscle cell development (GO:0055015)4.63742523
44pericardium development (GO:0060039)4.58775059
45cell communication by electrical coupling (GO:0010644)4.56270393
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53681223
47negative regulation of protein localization to cell surface (GO:2000009)4.51483564
48* negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.48355521
49cell communication involved in cardiac conduction (GO:0086065)4.48184943
50cardiac chamber formation (GO:0003207)4.46195762
51plasma membrane repair (GO:0001778)4.44796047
52cardiac muscle adaptation (GO:0014887)4.43943180
53cardiac muscle hypertrophy in response to stress (GO:0014898)4.43943180
54muscle hypertrophy in response to stress (GO:0003299)4.43943180
55* negative regulation of striated muscle cell apoptotic process (GO:0010664)4.42696089
56atrial septum morphogenesis (GO:0060413)4.42458338
57negative regulation of hormone metabolic process (GO:0032351)4.40623409
58regulation of glucocorticoid metabolic process (GO:0031943)4.33503467
59endocardial cushion development (GO:0003197)4.23586069
60regulation of transforming growth factor beta2 production (GO:0032909)4.22542001
61ATP synthesis coupled proton transport (GO:0015986)4.21260578
62energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21260578
63cell migration involved in heart development (GO:0060973)4.20981233
64carnitine shuttle (GO:0006853)4.16857712
65regulation of membrane repolarization (GO:0060306)4.15679490
66endocardial cushion morphogenesis (GO:0003203)4.13290365
67regulation of heart rate (GO:0002027)4.10654148
68regulation of cardiac muscle contraction (GO:0055117)4.08356988
69bone trabecula formation (GO:0060346)4.06472205
70outflow tract septum morphogenesis (GO:0003148)4.04570666
71desmosome organization (GO:0002934)4.00942258
72striated muscle cell development (GO:0055002)4.00701895
73response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.00565194
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.00534507
75cardiac muscle cell action potential (GO:0086001)3.99623643
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.98554675
77cardiac muscle cell action potential involved in contraction (GO:0086002)3.95906916
78regulation of cell communication by electrical coupling (GO:0010649)3.95009436
79regulation of ATP catabolic process (GO:1903289)3.92534190
80regulation of ATPase activity (GO:0043462)3.92534190
81regulation of cardiac muscle cell contraction (GO:0086004)3.92044343
82relaxation of cardiac muscle (GO:0055119)3.91812216
83cardiac right ventricle morphogenesis (GO:0003215)3.77163214
84trabecula formation (GO:0060343)3.76565330
85embryonic heart tube development (GO:0035050)3.74887422
86positive regulation of heart growth (GO:0060421)3.74037138
87regulation of heart contraction (GO:0008016)3.73383479
88oxidative phosphorylation (GO:0006119)3.71674312
89regulation of cardiac muscle cell proliferation (GO:0060043)3.69917410
90mesenchyme morphogenesis (GO:0072132)3.68622877
91* positive regulation of cardiac muscle tissue development (GO:0055025)3.67740128
92sarcoplasmic reticulum calcium ion transport (GO:0070296)3.63662598
93regulation of acyl-CoA biosynthetic process (GO:0050812)3.61725563
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.61492243
95cardiac conduction (GO:0061337)3.56254886
96* regulation of muscle contraction (GO:0006937)3.54158330
97positive regulation of cardiac muscle tissue growth (GO:0055023)3.53342723
98positive regulation of cardiac muscle cell proliferation (GO:0060045)3.52922379
99gap junction assembly (GO:0016264)3.52114591
100regulation of heart rate by cardiac conduction (GO:0086091)3.51264559
101relaxation of smooth muscle (GO:0044557)3.49769767
102* regulation of cardiac muscle tissue development (GO:0055024)3.49424490
103fatty acid transmembrane transport (GO:1902001)3.46776998
104cardiac muscle tissue development (GO:0048738)3.46198742
105muscle cell development (GO:0055001)3.44302402
106negative regulation of potassium ion transport (GO:0043267)3.43027620
107cardiac septum development (GO:0003279)3.41785181
108heart valve morphogenesis (GO:0003179)3.41279129
109positive regulation of heart rate (GO:0010460)3.41191025
110embryonic foregut morphogenesis (GO:0048617)3.40888040
111regulation of coenzyme metabolic process (GO:0051196)3.38619474
112regulation of cofactor metabolic process (GO:0051193)3.38619474
113muscle contraction (GO:0006936)3.37627561
114respiratory electron transport chain (GO:0022904)3.36672040
115regulation of cardioblast proliferation (GO:0003264)3.32065223
116regulation of secondary heart field cardioblast proliferation (GO:0003266)3.32065223
117cardiac ventricle formation (GO:0003211)3.31295251
118positive regulation of heart contraction (GO:0045823)3.28755280
119* regulation of striated muscle cell apoptotic process (GO:0010662)3.28476204
120electron transport chain (GO:0022900)3.27787674
121positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.27011702
122membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.24263634
123regulation of heart growth (GO:0060420)3.21705467
124regulation of cardiac muscle tissue growth (GO:0055021)3.20440745
125muscle system process (GO:0003012)3.20199168
126venous blood vessel morphogenesis (GO:0048845)3.19547003
127cartilage morphogenesis (GO:0060536)3.18803644
128relaxation of muscle (GO:0090075)3.17863323
129epithelial cell-cell adhesion (GO:0090136)3.11967513
130positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.05285423
131cardiac septum morphogenesis (GO:0060411)3.02877712
132extracellular regulation of signal transduction (GO:1900115)3.01637091
133extracellular negative regulation of signal transduction (GO:1900116)3.01637091
134heart morphogenesis (GO:0003007)3.00545442
135regulation of tight junction assembly (GO:2000810)3.00385974
136endoderm formation (GO:0001706)2.95120506
137cardiac myofibril assembly (GO:0055003)10.4325132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse6.56785783
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43657095
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02057135
4MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.01338633
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.97250987
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.97250987
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.80944305
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.69853990
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.69840673
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.49628653
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.22727352
12TRIM28_21343339_ChIP-Seq_HEK293_Human3.00518373
13GATA4_21415370_ChIP-Seq_HL-1_Mouse2.84971307
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.73814128
15* ISL1_27105846_Chip-Seq_CPCs_Mouse2.43979315
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.25943412
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18970812
18EZH2_22144423_ChIP-Seq_EOC_Human2.06876780
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.01276425
20NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.00683476
21NRF2_20460467_ChIP-Seq_MEFs_Mouse1.92937161
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.92937161
23* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76924329
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72948253
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71944096
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70787804
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68697463
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67492377
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.67279291
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66490967
31TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.65780713
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65630712
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59202210
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58351504
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50385870
36BRD4_25478319_ChIP-Seq_HGPS_Human1.44643102
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43139713
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42229645
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41936192
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41936192
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41181885
42TP53_18474530_ChIP-ChIP_U2OS_Human1.40594580
43P300_19829295_ChIP-Seq_ESCs_Human1.40066857
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.38303814
45TAF15_26573619_Chip-Seq_HEK293_Human1.37242938
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36890832
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35543555
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33374346
49* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28617360
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28299326
51CJUN_26792858_Chip-Seq_BT549_Human1.27459554
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.26134249
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25410878
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25330343
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23607176
56BCAT_22108803_ChIP-Seq_LS180_Human1.22303345
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21322735
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21320100
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20757109
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20554743
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18960570
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18324743
63TP53_16413492_ChIP-PET_HCT116_Human1.17910765
64VDR_22108803_ChIP-Seq_LS180_Human1.16385181
65* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15071242
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14228456
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14033262
68FUS_26573619_Chip-Seq_HEK293_Human1.13739095
69GATA1_22025678_ChIP-Seq_K562_Human1.12149505
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11992891
71* SMAD3_21741376_ChIP-Seq_HESCs_Human1.11221952
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09772312
73STAT3_23295773_ChIP-Seq_U87_Human1.08264188
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.07088606
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06910406
76EOMES_21245162_ChIP-Seq_HESCs_Human1.05483440
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05111252
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04940855
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04789363
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04065635
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04045636
82TCF4_23295773_ChIP-Seq_U87_Human1.03569491
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.03162491
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02791442
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.02391890
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02288688
87* SMAD4_21799915_ChIP-Seq_A2780_Human1.01037210
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00516802
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00469097
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00084943
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99337663
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98958379
93ZNF274_21170338_ChIP-Seq_K562_Hela0.98765299
94CLOCK_20551151_ChIP-Seq_293T_Human0.97802058
95JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97683471
96AHR_22903824_ChIP-Seq_MCF-7_Human0.97092867
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97072131
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96406238
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95318842
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95289263
101TCF4_18268006_ChIP-ChIP_LS174T_Human0.95237648
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94914035
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94248706
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92805759
105* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92637742
106SOX2_21211035_ChIP-Seq_LN229_Gbm0.92060930
107MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92035146
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89931848
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89879305
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89253442
111* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88323603
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87187158
113* SMAD3_21741376_ChIP-Seq_EPCs_Human0.86707492
114GBX2_23144817_ChIP-Seq_PC3_Human0.86346113
115RNF2_27304074_Chip-Seq_ESCs_Mouse0.85424050
116TBL1_22424771_ChIP-Seq_293T_Human0.85241763
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83767796
118AR_19668381_ChIP-Seq_PC3_Human0.82131566
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80969199
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78836096
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.78639762
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.77237224
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76750859
124* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75754377
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.75565858
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75335453
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.73252376
128VDR_24787735_ChIP-Seq_THP-1_Human0.72337237
129ZNF263_19887448_ChIP-Seq_K562_Human0.71829769
130GF1_26923725_Chip-Seq_HPCs_Mouse0.71790288
131DROSHA_22980978_ChIP-Seq_HELA_Human0.71118286
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.70225699
133* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69875687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.69401174
2MP0002837_dystrophic_cardiac_calcinosis5.64873520
3MP0004215_abnormal_myocardial_fiber4.61717081
4MP0004036_abnormal_muscle_relaxation4.59403163
5MP0000749_muscle_degeneration4.18255106
6MP0000751_myopathy4.07857089
7MP0005330_cardiomyopathy4.07670751
8MP0003646_muscle_fatigue3.91183001
9MP0002972_abnormal_cardiac_muscle3.64803888
10MP0008775_abnormal_heart_ventricle3.56764215
11MP0003137_abnormal_impulse_conducting3.06043980
12MP0004087_abnormal_muscle_fiber2.92462661
13MP0004510_myositis2.92219339
14MP0005620_abnormal_muscle_contractility2.92057884
15MP0010630_abnormal_cardiac_muscle2.91083044
16MP0006138_congestive_heart_failure2.79414202
17MP0005385_cardiovascular_system_phenoty2.77704451
18MP0001544_abnormal_cardiovascular_syste2.77704451
19MP0003828_pulmonary_edema2.68589885
20MP0004085_abnormal_heartbeat2.47390466
21MP0002127_abnormal_cardiovascular_syste2.36432031
22MP0004484_altered_response_of2.36117964
23MP0002106_abnormal_muscle_physiology2.29784133
24MP0003221_abnormal_cardiomyocyte_apopto2.27188587
25MP0002102_abnormal_ear_morphology2.23643704
26MP0000750_abnormal_muscle_regeneration2.19712238
27MP0004145_abnormal_muscle_electrophysio2.18390516
28MP0000462_abnormal_digestive_system2.06855412
29MP0002269_muscular_atrophy1.97728719
30MP0003567_abnormal_fetal_cardiomyocyte1.96639149
31MP0003950_abnormal_plasma_membrane1.91133833
32MP0001958_emphysema1.89415975
33MP0005369_muscle_phenotype1.87750157
34MP0003890_abnormal_embryonic-extraembry1.75018070
35MP0005451_abnormal_body_composition1.68559210
36MP0004233_abnormal_muscle_weight1.65086694
37MP0003122_maternal_imprinting1.64577299
38MP0000534_abnormal_ureter_morphology1.60829186
39MP0000759_abnormal_skeletal_muscle1.53954217
40MP0004130_abnormal_muscle_cell1.47062962
41MP0003279_aneurysm1.40956012
42MP0000747_muscle_weakness1.39453671
43MP0006054_spinal_hemorrhage1.32519467
44* MP0000266_abnormal_heart_morphology1.31711977
45MP0004272_abnormal_basement_membrane1.22738534
46MP0010368_abnormal_lymphatic_system1.20362373
47MP0006036_abnormal_mitochondrial_physio1.19444183
48MP0010030_abnormal_orbit_morphology1.19128463
49MP0009384_cardiac_valve_regurgitation1.14537596
50MP0005508_abnormal_skeleton_morphology1.07279209
51MP0001661_extended_life_span1.06998968
52MP0002332_abnormal_exercise_endurance1.03831752
53MP0003566_abnormal_cell_adhesion1.03785009
54MP0005623_abnormal_meninges_morphology1.02452500
55MP0008004_abnormal_stomach_pH0.99776888
56MP0002234_abnormal_pharynx_morphology0.98974921
57MP0003091_abnormal_cell_migration0.98908298
58MP0000343_altered_response_to0.97645805
59MP0002128_abnormal_blood_circulation0.95077164
60MP0003121_genomic_imprinting0.94594892
61MP0005257_abnormal_intraocular_pressure0.91433403
62MP0001299_abnormal_eye_distance/0.91195965
63MP0005248_abnormal_Harderian_gland0.89921402
64MP0003123_paternal_imprinting0.88934104
65MP0005670_abnormal_white_adipose0.88692368
66MP0000230_abnormal_systemic_arterial0.87688264
67MP0002697_abnormal_eye_size0.85673285
68MP0005165_increased_susceptibility_to0.83856545
69MP0003283_abnormal_digestive_organ0.79994289
70MP0003385_abnormal_body_wall0.79033956
71MP0000538_abnormal_urinary_bladder0.77397504
72MP0003941_abnormal_skin_development0.76173855
73MP0009053_abnormal_anal_canal0.74683626
74MP0001879_abnormal_lymphatic_vessel0.74549257
75* MP0002925_abnormal_cardiovascular_devel0.73947517
76MP0002254_reproductive_system_inflammat0.73711122
77MP0002233_abnormal_nose_morphology0.73165107
78MP0000013_abnormal_adipose_tissue0.70431935
79MP0002115_abnormal_skeleton_extremities0.70079134
80MP0005666_abnormal_adipose_tissue0.69967206
81* MP0002088_abnormal_embryonic_growth/wei0.69544774
82MP0002109_abnormal_limb_morphology0.69445447
83MP0002108_abnormal_muscle_morphology0.69195828
84* MP0003984_embryonic_growth_retardation0.68241195
85MP0005503_abnormal_tendon_morphology0.68097234
86MP0000049_abnormal_middle_ear0.67489370
87MP0006035_abnormal_mitochondrial_morpho0.67467846
88MP0005023_abnormal_wound_healing0.66267028
89MP0003755_abnormal_palate_morphology0.65985560
90MP0000163_abnormal_cartilage_morphology0.65727014
91MP0000432_abnormal_head_morphology0.65295732
92MP0002084_abnormal_developmental_patter0.64943079
93MP0005197_abnormal_uvea_morphology0.63124259
94* MP0000767_abnormal_smooth_muscle0.62993536
95MP0005595_abnormal_vascular_smooth0.58757800
96MP0008438_abnormal_cutaneous_collagen0.58466340
97* MP0001784_abnormal_fluid_regulation0.53990979
98* MP0001614_abnormal_blood_vessel0.53153454
99MP0003806_abnormal_nucleotide_metabolis0.53081340
100MP0005266_abnormal_metabolism0.46869721
101MP0003935_abnormal_craniofacial_develop0.44366478
102* MP0001672_abnormal_embryogenesis/_devel0.43491182
103* MP0005380_embryogenesis_phenotype0.43491182
104MP0003705_abnormal_hypodermis_morpholog0.42929870
105MP0005367_renal/urinary_system_phenotyp0.42434732
106MP0000516_abnormal_urinary_system0.42434732
107MP0005388_respiratory_system_phenotype0.41457771
108MP0002133_abnormal_respiratory_system0.41457771
109MP0009697_abnormal_copulation0.40317278
110MP0005187_abnormal_penis_morphology0.39879056
111MP0005375_adipose_tissue_phenotype0.39797929
112MP0000733_abnormal_muscle_development0.39697857
113MP0002249_abnormal_larynx_morphology0.37413120
114MP0002638_abnormal_pupillary_reflex0.35677659
115MP0000537_abnormal_urethra_morphology0.35536454
116MP0000762_abnormal_tongue_morphology0.35382220
117* MP0003948_abnormal_gas_homeostasis0.34206330
118MP0001175_abnormal_lung_morphology0.33936253
119MP0009250_abnormal_appendicular_skeleto0.33565848
120MP0003115_abnormal_respiratory_system0.33038583
121MP0005377_hearing/vestibular/ear_phenot0.32533693
122MP0003878_abnormal_ear_physiology0.32533693
123MP0000428_abnormal_craniofacial_morphol0.29931019
124MP0005275_abnormal_skin_tensile0.29481281
125MP0009672_abnormal_birth_weight0.24645896
126MP0001727_abnormal_embryo_implantation0.24430555
127MP0002282_abnormal_trachea_morphology0.23998057
128MP0003119_abnormal_digestive_system0.23806898
129MP0003937_abnormal_limbs/digits/tail_de0.23380716
130MP0003942_abnormal_urinary_system0.23368553

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)9.17637154
2Ventricular tachycardia (HP:0004756)7.33405575
3Atrial fibrillation (HP:0005110)6.99391353
4Primary atrial arrhythmia (HP:0001692)6.50723080
5Calf muscle hypertrophy (HP:0008981)6.43696430
6Supraventricular tachycardia (HP:0004755)6.29246612
7Supraventricular arrhythmia (HP:0005115)6.17173183
8Lipoatrophy (HP:0100578)6.14070950
9Abnormality of the left ventricular outflow tract (HP:0011103)5.90942553
10Subaortic stenosis (HP:0001682)5.90942553
11Muscle hypertrophy of the lower extremities (HP:0008968)5.70173331
12Exercise-induced muscle cramps (HP:0003710)5.60154697
13Abnormality of the calf musculature (HP:0001430)5.48471394
14Right ventricular cardiomyopathy (HP:0011663)5.36164185
15Syncope (HP:0001279)5.27135254
16Aortic dissection (HP:0002647)5.02778005
17Prolonged QT interval (HP:0001657)4.79682461
18Exercise-induced myalgia (HP:0003738)4.74562328
19Ventricular arrhythmia (HP:0004308)4.72807353
20Dilated cardiomyopathy (HP:0001644)4.72317836
21Muscle fiber splitting (HP:0003555)4.68128382
22Palpitations (HP:0001962)4.48065647
23Hyporeflexia of lower limbs (HP:0002600)4.43090482
24Premature rupture of membranes (HP:0001788)4.42479654
25Bundle branch block (HP:0011710)4.19971319
26EMG: myopathic abnormalities (HP:0003458)3.99603295
27Asymmetric septal hypertrophy (HP:0001670)3.78379440
28Myoglobinuria (HP:0002913)3.74736418
29Heart block (HP:0012722)3.68818192
30Atrioventricular block (HP:0001678)3.61945810
31Ventricular fibrillation (HP:0001663)3.57954489
32Abnormal EKG (HP:0003115)3.50906565
33Abnormal atrioventricular conduction (HP:0005150)3.46330755
34Congenital malformation of the right heart (HP:0011723)3.43117469
35Double outlet right ventricle (HP:0001719)3.43117469
36Left ventricular hypertrophy (HP:0001712)3.35666858
37Mitral valve prolapse (HP:0001634)3.20924572
38Arterial tortuosity (HP:0005116)3.19308272
39Vascular tortuosity (HP:0004948)3.14176961
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.98152648
41Rhabdomyolysis (HP:0003201)2.97038602
42Palmoplantar keratoderma (HP:0000982)2.95947721
43Hypoplastic left heart (HP:0004383)2.94681904
44Protrusio acetabuli (HP:0003179)2.93242381
45Ragged-red muscle fibers (HP:0003200)2.89575789
46Patent foramen ovale (HP:0001655)2.88859665
47Increased connective tissue (HP:0009025)2.87827779
48Limited hip movement (HP:0008800)2.80138001
49Soft skin (HP:0000977)2.76230696
50Acute necrotizing encephalopathy (HP:0006965)2.61590561
51Abnormal mitochondria in muscle tissue (HP:0008316)2.59651057
52Aneurysm (HP:0002617)2.59120168
53Bicuspid aortic valve (HP:0001647)2.58798701
54Vitreoretinal degeneration (HP:0000655)2.56854011
55Type 1 muscle fiber predominance (HP:0003803)2.54030044
56Myotonia (HP:0002486)2.48721612
57Neck muscle weakness (HP:0000467)2.48019082
58Dilatation of the ascending aorta (HP:0005111)2.46028416
59Distal lower limb muscle weakness (HP:0009053)2.43767999
60Hepatic necrosis (HP:0002605)2.40118374
61Diaphragmatic weakness (HP:0009113)2.38214851
62Pulmonary artery stenosis (HP:0004415)2.36561409
63Rimmed vacuoles (HP:0003805)2.33320596
64Spondylolisthesis (HP:0003302)2.32831160
65Neoplasm of the adrenal gland (HP:0100631)2.31630891
66Preauricular pit (HP:0004467)2.29121509
67Periauricular skin pits (HP:0100277)2.29121509
68Abnormality of the foot musculature (HP:0001436)2.28817112
69Knee flexion contracture (HP:0006380)2.27454053
70Hypoplastic heart (HP:0001961)2.27118210
71Conjunctival hamartoma (HP:0100780)2.25141332
72Partial duplication of thumb phalanx (HP:0009944)2.24646397
73Partial duplication of the phalanx of hand (HP:0009999)2.21158233
74Exercise intolerance (HP:0003546)2.18705728
75Preaxial foot polydactyly (HP:0001841)2.15216971
76Mitochondrial inheritance (HP:0001427)2.14301648
77Sudden cardiac death (HP:0001645)2.11753613
78Atrophic scars (HP:0001075)2.11460708
79Progressive macrocephaly (HP:0004481)2.09728646
80Ectopia lentis (HP:0001083)2.09341939
81Congestive heart failure (HP:0001635)2.08931313
82Hypoplastic ischia (HP:0003175)2.08465001
83Increased CSF lactate (HP:0002490)2.07431541
84Pheochromocytoma (HP:0002666)2.07379977
85Abnormality of glycolysis (HP:0004366)2.05943204
86Increased serum pyruvate (HP:0003542)2.05943204
87Fragile skin (HP:0001030)2.05345824
88Hypoglycemic coma (HP:0001325)2.05092666
89Steppage gait (HP:0003376)2.04959690
90Hepatocellular necrosis (HP:0001404)2.04792409
91Myelomeningocele (HP:0002475)2.04558721
92Generalized muscle weakness (HP:0003324)2.03014043
93Acute encephalopathy (HP:0006846)2.02863934
94Cerebral aneurysm (HP:0004944)1.99942305
95Bell-shaped thorax (HP:0001591)1.99853007
96Bladder diverticulum (HP:0000015)1.99569294
97Mildly elevated creatine phosphokinase (HP:0008180)1.97551792
98Wide anterior fontanel (HP:0000260)1.97375203
99Overgrowth (HP:0001548)1.96608304
100Lymphangioma (HP:0100764)1.94810920
101Transposition of the great arteries (HP:0001669)1.94453348
102Abnormal connection of the cardiac segments (HP:0011545)1.94453348
103Abnormal ventriculo-arterial connection (HP:0011563)1.94453348
104Abnormal umbilical cord blood vessels (HP:0011403)1.93360142
105Single umbilical artery (HP:0001195)1.93360142
106Abnormality of the fetal cardiovascular system (HP:0010948)1.93360142
107Neonatal short-limb short stature (HP:0008921)1.93343269
108Disproportionate tall stature (HP:0001519)1.91710832
109Foot dorsiflexor weakness (HP:0009027)1.90636079
110Skin pits (HP:0100276)1.89449270
111Ketoacidosis (HP:0001993)1.88707418
112Areflexia of lower limbs (HP:0002522)1.88500264
113Muscle stiffness (HP:0003552)1.84863435
114Pancreatic islet-cell hyperplasia (HP:0004510)1.83790854
115Coronal craniosynostosis (HP:0004440)1.82979967
116EMG: neuropathic changes (HP:0003445)1.82799578
117Abnormality of dentin (HP:0010299)1.81854909
118Abnormality of the ischium (HP:0003174)1.80627757
119Bradycardia (HP:0001662)1.80539942
120Mitral regurgitation (HP:0001653)1.80424910
121Mesomelia (HP:0003027)1.80012317
122Peritonitis (HP:0002586)1.79866645
123Difficulty running (HP:0009046)1.77622693
124Infantile muscular hypotonia (HP:0008947)1.77526305
125Scapular winging (HP:0003691)1.77207917
126Cerebral edema (HP:0002181)1.76793031
127Neuroendocrine neoplasm (HP:0100634)1.74943379
128Coarctation of aorta (HP:0001680)1.71049075
129Elbow flexion contracture (HP:0002987)1.70655854
130Wormian bones (HP:0002645)1.70480244
131Ankle contracture (HP:0006466)1.69512638
132Abnormal pancreas size (HP:0012094)1.68446438
133Chorioretinal atrophy (HP:0000533)1.68412937
134Respiratory failure (HP:0002878)1.68363877
135Hypoplasia of the iris (HP:0007676)1.67827595
136Aortic aneurysm (HP:0004942)1.65329051
137Blue sclerae (HP:0000592)1.65298752
138Muscular dystrophy (HP:0003560)1.65097637
139Increased muscle lipid content (HP:0009058)1.64709210
140Broad metatarsal (HP:0001783)1.63949684
141Abnormality of the lumbar spine (HP:0100712)1.63935806
142Abnormality of the tricuspid valve (HP:0001702)1.62422712
143Hip contracture (HP:0003273)1.60983731
144Complete atrioventricular canal defect (HP:0001674)1.60819010
145Lactic acidosis (HP:0003128)1.60538187
146Dicarboxylic aciduria (HP:0003215)1.59833573
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.59833573
148Hamartoma of the eye (HP:0010568)1.59319060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.16591454
2MYLK5.70382875
3STK243.83163665
4TTN3.46714541
5DMPK3.35903259
6ZAK3.21441722
7PIK3CA3.00459179
8PKN22.92148745
9LMTK22.83306775
10STK38L2.53684725
11PHKG12.36010864
12PHKG22.36010864
13ACVR1B2.13662834
14CDC42BPA1.96900911
15NEK91.93703981
16PDK41.91824666
17PDK31.91824666
18TIE11.77568478
19MUSK1.69577674
20DDR21.65669653
21ILK1.56020341
22PIK3CG1.35894639
23BCKDK1.35360817
24ROCK11.33517185
25INSRR1.28927345
26NEK11.27196945
27TRIB31.19029203
28TRPM71.18296186
29CAMK2D1.16447902
30STK41.16058911
31PAK31.15642374
32PTK2B1.06058784
33LIMK11.05759456
34FLT31.05013785
35WNK41.03977570
36PRKD11.03928751
37PDK21.03785050
38BMPR1B1.03384188
39DAPK31.01875284
40GRK71.00934691
41PTK20.92666927
42TNIK0.86488776
43MAPKAPK30.84650643
44RET0.80294845
45STK30.79431881
46MAP3K50.79258212
47PRKAA20.78760490
48PLK40.77463711
49NUAK10.74976091
50WNK10.74679582
51CAMK10.73812706
52PINK10.73047324
53MAP3K30.71458321
54PKN10.71006817
55LATS10.70803599
56MAPK120.69710281
57PAK20.69294225
58NLK0.68603433
59MET0.67608691
60MAP3K70.64484926
61STK390.63361480
62PRKAA10.62067919
63PDGFRB0.61842492
64KDR0.60934268
65FRK0.59950751
66EPHB20.57922916
67ERBB40.57565050
68PRKD30.56715953
69PDGFRA0.56601376
70ROCK20.55988074
71BRSK20.55504502
72RIPK10.55474956
73CAMK2A0.53725752
74PRKACB0.52014088
75TESK10.50008576
76CAMK40.49772301
77PRKCE0.44991801
78RPS6KC10.44117964
79RPS6KL10.44117964
80MAP2K10.43366981
81STK380.42329115
82PRKG10.41145740
83PRKACA0.41067919
84MAP2K30.40618527
85CAMK1G0.33892984
86RPS6KA60.33695355
87PBK0.32851691
88MAPK40.31064712
89MAP3K100.30661605
90LATS20.30637402
91PRKD20.30548976
92TGFBR20.30158981
93MAP3K60.29260341
94AKT20.29226946
95PRKG20.28598491
96ERBB30.25870518
97MARK30.25749239
98PNCK0.25644220
99PRKACG0.25440563
100CAMK2G0.24900951
101AKT30.24426596
102RAF10.23614917
103NME20.23123338
104FGFR10.22940098
105GSK3A0.22479558
106PRKCQ0.19909742
107SGK20.19631461
108RPS6KA20.19230277
109PRKCH0.18074510
110BCR0.17749737
111MAPK70.15942835
112EPHA40.15815315
113CDK40.15695975
114PAK10.14619533
115SGK30.14396774
116AKT10.14348346
117ADRBK10.14263420
118TGFBR10.14218758
119MKNK20.11677069
120PAK40.11669675
121PRPF4B0.11666039
122MAP3K120.11611184
123EEF2K0.11265679
124FER0.11240939
125MAPKAPK20.10586725
126IGF1R0.09803664
127MTOR0.09104986
128BLK0.08329570
129PTK60.07559887
130SGK10.07330037
131SIK10.06258575
132PLK20.04860274
133MELK0.04628310

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.60951962
2Cardiac muscle contraction_Homo sapiens_hsa042605.50366636
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.89639665
4Dilated cardiomyopathy_Homo sapiens_hsa054144.79386220
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.57015696
6Parkinsons disease_Homo sapiens_hsa050123.33914276
7Oxidative phosphorylation_Homo sapiens_hsa001903.21092776
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.99680176
9Propanoate metabolism_Homo sapiens_hsa006402.49337919
10Alzheimers disease_Homo sapiens_hsa050102.37707511
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.26452617
12Carbon metabolism_Homo sapiens_hsa012002.26014465
13Huntingtons disease_Homo sapiens_hsa050162.25881899
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03680219
15Fatty acid degradation_Homo sapiens_hsa000711.95212244
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85695397
17Viral myocarditis_Homo sapiens_hsa054161.65873521
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54776597
19Fatty acid metabolism_Homo sapiens_hsa012121.54350692
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.46003500
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45804499
22Pyruvate metabolism_Homo sapiens_hsa006201.45409004
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35156966
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18460379
25Biosynthesis of amino acids_Homo sapiens_hsa012301.15195594
26Focal adhesion_Homo sapiens_hsa045101.14552043
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12188529
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08179992
29Fatty acid elongation_Homo sapiens_hsa000621.08080614
30HIF-1 signaling pathway_Homo sapiens_hsa040661.03442400
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02943045
32Glucagon signaling pathway_Homo sapiens_hsa049221.02500192
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02464434
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.01969485
35Tight junction_Homo sapiens_hsa045301.00975099
36ECM-receptor interaction_Homo sapiens_hsa045120.92478258
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89175482
38Calcium signaling pathway_Homo sapiens_hsa040200.88157395
39Insulin resistance_Homo sapiens_hsa049310.85249680
40Starch and sucrose metabolism_Homo sapiens_hsa005000.84465710
41Galactose metabolism_Homo sapiens_hsa000520.82159475
42Adherens junction_Homo sapiens_hsa045200.80278731
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79148844
44Oxytocin signaling pathway_Homo sapiens_hsa049210.77938681
45Endometrial cancer_Homo sapiens_hsa052130.77194590
46Lysine degradation_Homo sapiens_hsa003100.73917720
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.72833754
48Fructose and mannose metabolism_Homo sapiens_hsa000510.69871473
49Insulin signaling pathway_Homo sapiens_hsa049100.66755372
50Butanoate metabolism_Homo sapiens_hsa006500.65503546
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.65242407
52Pancreatic secretion_Homo sapiens_hsa049720.63494287
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63114177
54Type II diabetes mellitus_Homo sapiens_hsa049300.61230023
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60825850
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.60706478
57PPAR signaling pathway_Homo sapiens_hsa033200.56542145
58Mineral absorption_Homo sapiens_hsa049780.56285532
59cAMP signaling pathway_Homo sapiens_hsa040240.54412681
60Axon guidance_Homo sapiens_hsa043600.51824921
61Choline metabolism in cancer_Homo sapiens_hsa052310.51645204
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51516095
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50543740
64Circadian entrainment_Homo sapiens_hsa047130.48191131
65Renin secretion_Homo sapiens_hsa049240.48110627
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47511281
67Thyroid hormone synthesis_Homo sapiens_hsa049180.45811683
68Prostate cancer_Homo sapiens_hsa052150.45755139
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.44978916
70Malaria_Homo sapiens_hsa051440.43690889
71AMPK signaling pathway_Homo sapiens_hsa041520.42919155
72Proteoglycans in cancer_Homo sapiens_hsa052050.42287717
73Tryptophan metabolism_Homo sapiens_hsa003800.42212791
74Phenylalanine metabolism_Homo sapiens_hsa003600.42101089
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41991427
76Hippo signaling pathway_Homo sapiens_hsa043900.41441349
77Insulin secretion_Homo sapiens_hsa049110.40830854
78Basal cell carcinoma_Homo sapiens_hsa052170.38362962
79Salivary secretion_Homo sapiens_hsa049700.38282755
80Dorso-ventral axis formation_Homo sapiens_hsa043200.38050572
81GnRH signaling pathway_Homo sapiens_hsa049120.37879635
82Colorectal cancer_Homo sapiens_hsa052100.37843897
83TGF-beta signaling pathway_Homo sapiens_hsa043500.37567500
84Circadian rhythm_Homo sapiens_hsa047100.37048225
85Amoebiasis_Homo sapiens_hsa051460.34821433
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34740493
87Glycerolipid metabolism_Homo sapiens_hsa005610.33788324
88Arginine and proline metabolism_Homo sapiens_hsa003300.33371976
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32364071
90Thyroid cancer_Homo sapiens_hsa052160.31315095
91Sulfur metabolism_Homo sapiens_hsa009200.30838015
92Glioma_Homo sapiens_hsa052140.30411435
93Pancreatic cancer_Homo sapiens_hsa052120.29941367
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29044409
95Serotonergic synapse_Homo sapiens_hsa047260.26638541
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25703192
97Ovarian steroidogenesis_Homo sapiens_hsa049130.25307818
98beta-Alanine metabolism_Homo sapiens_hsa004100.25182617
99Chronic myeloid leukemia_Homo sapiens_hsa052200.24866195
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24597263
101Bile secretion_Homo sapiens_hsa049760.24471568
102Fatty acid biosynthesis_Homo sapiens_hsa000610.24204415
103Hedgehog signaling pathway_Homo sapiens_hsa043400.24187258
104Olfactory transduction_Homo sapiens_hsa047400.23542919
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23287570
106Metabolic pathways_Homo sapiens_hsa011000.21340503
107Tyrosine metabolism_Homo sapiens_hsa003500.20497662
108Morphine addiction_Homo sapiens_hsa050320.20398418
109Protein digestion and absorption_Homo sapiens_hsa049740.20378958
110Small cell lung cancer_Homo sapiens_hsa052220.20067655
111Ras signaling pathway_Homo sapiens_hsa040140.19890384
112Gastric acid secretion_Homo sapiens_hsa049710.17916871
113Pathways in cancer_Homo sapiens_hsa052000.17655373
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17439347
115Melanogenesis_Homo sapiens_hsa049160.16242510
116Wnt signaling pathway_Homo sapiens_hsa043100.12720935
117Peroxisome_Homo sapiens_hsa041460.12585728
118Platelet activation_Homo sapiens_hsa046110.12072551
119Rap1 signaling pathway_Homo sapiens_hsa040150.11684337
120RNA degradation_Homo sapiens_hsa030180.11552235
121Taste transduction_Homo sapiens_hsa047420.11471802
122Melanoma_Homo sapiens_hsa052180.11010901
123FoxO signaling pathway_Homo sapiens_hsa040680.06416736
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05558118
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.03747509
126MicroRNAs in cancer_Homo sapiens_hsa052060.03263331
127Cholinergic synapse_Homo sapiens_hsa047250.01359541
128Gap junction_Homo sapiens_hsa045400.01179614
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.00050142
130MAPK signaling pathway_Homo sapiens_hsa040100.00033050
131Renal cell carcinoma_Homo sapiens_hsa05211-0.0015397
132HTLV-I infection_Homo sapiens_hsa05166-0.0010109

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