MYOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striated muscle atrophy (GO:0014891)9.83791721
2muscle filament sliding (GO:0030049)9.63746313
3actin-myosin filament sliding (GO:0033275)9.63746313
4* skeletal muscle fiber development (GO:0048741)9.57207861
5positive regulation of skeletal muscle tissue development (GO:0048643)8.86488368
6response to stimulus involved in regulation of muscle adaptation (GO:0014874)8.85354541
7muscle atrophy (GO:0014889)8.47787379
8musculoskeletal movement (GO:0050881)8.24179587
9multicellular organismal movement (GO:0050879)8.24179587
10plasma membrane repair (GO:0001778)8.11992959
11actin-mediated cell contraction (GO:0070252)8.11981618
12* myotube cell development (GO:0014904)8.00276491
13myoblast fusion (GO:0007520)7.73827788
14positive regulation of myoblast differentiation (GO:0045663)7.69421651
15* positive regulation of myotube differentiation (GO:0010831)7.67877433
16syncytium formation by plasma membrane fusion (GO:0000768)7.10510176
17syncytium formation (GO:0006949)6.68565907
18regulation of skeletal muscle contraction (GO:0014819)6.52757877
19response to muscle activity (GO:0014850)6.52574362
20muscle cell cellular homeostasis (GO:0046716)6.38948392
21actin filament-based movement (GO:0030048)6.19260424
22sarcomere organization (GO:0045214)5.86152186
23regulation of protein heterodimerization activity (GO:0043497)5.45595858
24neuromuscular synaptic transmission (GO:0007274)5.44955360
25* regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.41741776
26mRNA transcription from RNA polymerase II promoter (GO:0042789)5.32387937
27striated muscle contraction (GO:0006941)5.22785570
28* muscle fiber development (GO:0048747)5.20531794
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.08588522
30sarcoplasmic reticulum calcium ion transport (GO:0070296)5.04464137
31* skeletal muscle tissue development (GO:0007519)5.01612963
32striated muscle adaptation (GO:0014888)4.98249288
33regulation of relaxation of muscle (GO:1901077)4.97414053
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.90238373
35skeletal muscle tissue regeneration (GO:0043403)4.89904017
36mRNA transcription (GO:0009299)4.88806135
37embryonic retina morphogenesis in camera-type eye (GO:0060059)4.83502925
38creatine metabolic process (GO:0006600)4.65863642
39* muscle organ development (GO:0007517)4.50652239
40neuromuscular junction development (GO:0007528)4.38948117
41* muscle structure development (GO:0061061)4.38664357
42regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.33736437
43* positive regulation of muscle cell differentiation (GO:0051149)4.32489854
44embryonic body morphogenesis (GO:0010172)4.26617859
45cardiac muscle contraction (GO:0060048)4.26097950
46muscle contraction (GO:0006936)4.23938368
47regulation of myoblast differentiation (GO:0045661)4.23309454
48cellular response to lithium ion (GO:0071285)4.21603692
49skeletal muscle cell differentiation (GO:0035914)4.15812986
50actomyosin structure organization (GO:0031032)4.14624733
51negative regulation of protein localization to cell surface (GO:2000009)4.12796257
52* striated muscle cell development (GO:0055002)4.09167519
53negative regulation of cell size (GO:0045792)4.02030779
54organ induction (GO:0001759)4.01359289
55postsynaptic membrane organization (GO:0001941)3.95113883
56muscle adaptation (GO:0043500)3.93781160
57muscle system process (GO:0003012)3.91952072
58regulation of striated muscle contraction (GO:0006942)3.90652800
59body morphogenesis (GO:0010171)3.90082045
60regulation of skeletal muscle cell differentiation (GO:2001014)3.88245491
61negative regulation of potassium ion transmembrane transport (GO:1901380)3.87883108
62glucan biosynthetic process (GO:0009250)3.87812307
63glycogen biosynthetic process (GO:0005978)3.87812307
64* muscle cell development (GO:0055001)3.86322246
65regulation of actin filament-based movement (GO:1903115)3.81654377
66embryonic camera-type eye development (GO:0031076)3.78529316
67response to activity (GO:0014823)3.76512255
68* regulation of myotube differentiation (GO:0010830)3.64838973
69regulation of sarcomere organization (GO:0060297)3.63946184
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.60875210
71regulation of skeletal muscle tissue development (GO:0048641)3.60600581
72muscle tissue morphogenesis (GO:0060415)3.58192510
73regulation of cell communication by electrical coupling (GO:0010649)3.57138922
74negative regulation of gluconeogenesis (GO:0045721)3.53934123
75* positive regulation of striated muscle cell differentiation (GO:0051155)3.47941094
76regulation of cardioblast proliferation (GO:0003264)3.46389832
77regulation of secondary heart field cardioblast proliferation (GO:0003266)3.46389832
78response to lithium ion (GO:0010226)3.44651735
79positive regulation of cell size (GO:0045793)3.41763732
80regulation of skeletal muscle fiber development (GO:0048742)3.39919517
81* regulation of muscle cell differentiation (GO:0051147)3.38320957
82negative regulation of muscle hypertrophy (GO:0014741)3.37288982
83face morphogenesis (GO:0060325)3.35392182
84* striated muscle tissue development (GO:0014706)3.32660463
85glycogen catabolic process (GO:0005980)3.32101138
86myofibril assembly (GO:0030239)3.30283839
87positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.28500245
88regulation of membrane repolarization (GO:0060306)3.28489782
89* cellular response to estradiol stimulus (GO:0071392)3.24547699
90positive regulation of muscle organ development (GO:0048636)3.21614766
91positive regulation of striated muscle tissue development (GO:0045844)3.21614766
92lens morphogenesis in camera-type eye (GO:0002089)3.20637119
93lens fiber cell differentiation (GO:0070306)3.18731320
94skeletal muscle adaptation (GO:0043501)3.17060459
95regulation of p38MAPK cascade (GO:1900744)3.12455142
96positive regulation of muscle tissue development (GO:1901863)3.11408631
97cranial nerve morphogenesis (GO:0021602)3.11078275
98regulation of glucose import in response to insulin stimulus (GO:2001273)3.10416452
99cardiac cell development (GO:0055006)3.10269146
100glucan catabolic process (GO:0009251)3.09004978
101heart contraction (GO:0060047)3.08871358
102heart process (GO:0003015)3.08871358
103regulation of muscle adaptation (GO:0043502)3.07494583
104regulation of muscle system process (GO:0090257)3.06117616
105cardiac muscle tissue morphogenesis (GO:0055008)3.05802412
106metanephric mesenchyme development (GO:0072075)3.04176108
107* muscle cell differentiation (GO:0042692)3.03645102
108myoblast migration (GO:0051451)3.01525541
109embryonic viscerocranium morphogenesis (GO:0048703)2.98060248
110cardiac myofibril assembly (GO:0055003)2.97619788
111outer ear morphogenesis (GO:0042473)2.97501869
112negative regulation of potassium ion transport (GO:0043267)2.97036863
113negative regulation of nitric-oxide synthase activity (GO:0051001)2.96715796
114regulation of calcium ion transmembrane transporter activity (GO:1901019)2.95991941
115regulation of calcium ion transmembrane transport (GO:1903169)2.95991941
116synaptic transmission, cholinergic (GO:0007271)2.95522840
117muscle organ morphogenesis (GO:0048644)2.94982699
118dopaminergic neuron differentiation (GO:0071542)2.94363035
119* muscle tissue development (GO:0060537)2.93365635
120plasma membrane fusion (GO:0045026)2.92560835
121positive regulation of protein depolymerization (GO:1901881)2.92419605
122regulation of alkaline phosphatase activity (GO:0010692)2.88701264
123NADH metabolic process (GO:0006734)2.85968381
124cellular polysaccharide catabolic process (GO:0044247)2.83391303
125negative regulation of fatty acid transport (GO:2000192)2.82901053
126response to parathyroid hormone (GO:0071107)2.81139975
127positive regulation of glycogen biosynthetic process (GO:0045725)2.79001412
128positive regulation of astrocyte differentiation (GO:0048711)2.75075442
129endochondral ossification (GO:0001958)2.70193138
130replacement ossification (GO:0036075)2.70193138
131kidney mesenchyme development (GO:0072074)2.63625007
132* regulation of striated muscle cell differentiation (GO:0051153)2.60839988
133regulation of organ formation (GO:0003156)2.56465874
134cardiac muscle cell development (GO:0055013)2.51396183
135skeletal muscle contraction (GO:0003009)11.3723511
136* muscle cell fate commitment (GO:0042693)10.4715013
137response to inactivity (GO:0014854)10.3956031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.65015389
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.22216211
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01535982
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.90537067
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.82111637
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.33157194
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19576524
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.07238256
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05033936
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.83468234
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.69885887
12CLOCK_20551151_ChIP-Seq_293T_Human2.59003526
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.49464303
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38530025
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.36193194
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32520434
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.28394419
18MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.25249849
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11622331
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.07272918
21P300_27058665_Chip-Seq_ZR-75-30cells_Human2.07035327
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04746578
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01526934
24TBX20_22080862_ChIP-Seq_HEART_Mouse2.00420493
25TBX20_22328084_ChIP-Seq_HEART_Mouse2.00420493
26* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00016274
27SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.97504869
28KDM2B_26808549_Chip-Seq_DND41_Human1.88658946
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88647972
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88392040
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.86560006
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78820838
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73753096
34RACK7_27058665_Chip-Seq_MCF-7_Human1.73333564
35ATF3_27146783_Chip-Seq_COLON_Human1.73266368
36ZNF263_19887448_ChIP-Seq_K562_Human1.65559749
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.65022758
38GATA4_21415370_ChIP-Seq_HL-1_Mouse1.63458974
39KDM2B_26808549_Chip-Seq_K562_Human1.63432355
40* ERG_21242973_ChIP-ChIP_JURKAT_Human1.62185992
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.61883616
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61861650
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61748066
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61253622
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.57972424
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.57514084
47CJUN_26792858_Chip-Seq_BT549_Human1.56163181
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54827665
49BRD4_25478319_ChIP-Seq_HGPS_Human1.53776346
50LXR_22292898_ChIP-Seq_THP-1_Human1.52500740
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51346623
52ZNF274_21170338_ChIP-Seq_K562_Hela1.49973529
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.49752850
54* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49428511
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48885089
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48102274
57* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47991413
58TCF7_22412390_ChIP-Seq_EML_Mouse1.47514079
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47340983
60* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47310254
61TP53_22127205_ChIP-Seq_IMR90_Human1.46769919
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46359998
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45016347
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.44747617
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43456498
66TP53_16413492_ChIP-PET_HCT116_Human1.43332767
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42741340
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.41144418
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40026759
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39327180
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39312317
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37638705
73* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37495575
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35746015
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33887782
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32088850
77* CTCF_26484167_Chip-Seq_Bcells_Mouse1.31832730
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30875808
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30224851
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.28836993
81CTCF_21964334_Chip-Seq_Bcells_Human1.28661064
82* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27728413
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27008633
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26572471
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25290952
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24536606
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24142064
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23732133
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23388861
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.23328098
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20650768
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20416312
93* MYC_27129775_Chip-Seq_CORNEA_Mouse1.19800268
94SOX11_22085726_ChIP-Seq_ESNs_Mouse1.19600952
95* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18928303
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17897559
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17121429
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15207384
99* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15199158
100CREB1_26743006_Chip-Seq_LNCaP_Human1.14625703
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.13685142
102* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13002013
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12675559
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11589066
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11589066
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10064096
107EZH2_22144423_ChIP-Seq_EOC_Human1.09693536
108TP53_23651856_ChIP-Seq_MEFs_Mouse1.08772758
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08111145
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06307405
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.06293301
112TP53_18474530_ChIP-ChIP_U2OS_Human1.06188877
113EGR1_19032775_ChIP-ChIP_M12_Human1.06001398
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04659141
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.03798588
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03043273
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02519641
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01024899
119SA1_27219007_Chip-Seq_Bcells_Human1.00457607
120GATA3_21867929_ChIP-Seq_CD8_Mouse0.99077454
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98457997
122* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96651612
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.96584850
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96525094
125CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96118066
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95595165
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95595165
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.93910381
129MYC_22102868_ChIP-Seq_BL_Human0.93795640
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92204722
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.91182136
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90872210
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90368582
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89458969
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88773761
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.88241414
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87446391
138CTCF_27219007_Chip-Seq_Bcells_Human0.87034470
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85581174
140VDR_21846776_ChIP-Seq_THP-1_Human0.85388713
141NFI_21473784_ChIP-Seq_ESCs_Mouse0.85117171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia5.56319161
2MP0000749_muscle_degeneration5.49412275
3* MP0000733_abnormal_muscle_development5.43677887
4MP0000751_myopathy5.28242321
5MP0004145_abnormal_muscle_electrophysio4.59850032
6MP0000747_muscle_weakness4.55653024
7* MP0000750_abnormal_muscle_regeneration4.32117145
8* MP0000759_abnormal_skeletal_muscle3.43725415
9MP0010030_abnormal_orbit_morphology3.33909453
10MP0004087_abnormal_muscle_fiber3.28134660
11* MP0002106_abnormal_muscle_physiology3.23645915
12MP0001542_abnormal_bone_strength2.95588017
13MP0003950_abnormal_plasma_membrane2.88913676
14* MP0005369_muscle_phenotype2.72606786
15MP0002269_muscular_atrophy2.67151728
16MP0005451_abnormal_body_composition2.51921303
17MP0004233_abnormal_muscle_weight2.49425261
18MP0009780_abnormal_chondrocyte_physiolo2.28366751
19MP0005623_abnormal_meninges_morphology2.14617737
20MP0002249_abnormal_larynx_morphology2.12136052
21MP0001299_abnormal_eye_distance/2.09228890
22MP0002837_dystrophic_cardiac_calcinosis2.03954109
23MP0002234_abnormal_pharynx_morphology1.94134847
24MP0004858_abnormal_nervous_system1.88578468
25MP0002877_abnormal_melanocyte_morpholog1.87029141
26MP0002971_abnormal_brown_adipose1.84385107
27* MP0002108_abnormal_muscle_morphology1.72132328
28MP0004084_abnormal_cardiac_muscle1.66658569
29MP0003705_abnormal_hypodermis_morpholog1.62252674
30MP0002734_abnormal_mechanical_nocicepti1.59966921
31MP0008438_abnormal_cutaneous_collagen1.59127706
32MP0005620_abnormal_muscle_contractility1.52031889
33MP0004036_abnormal_muscle_relaxation1.50255877
34MP0005330_cardiomyopathy1.48330701
35MP0001346_abnormal_lacrimal_gland1.45308306
36MP0004215_abnormal_myocardial_fiber1.28456826
37MP0002163_abnormal_gland_morphology1.28160621
38MP0010630_abnormal_cardiac_muscle1.26290675
39MP0003941_abnormal_skin_development1.20796873
40MP0002114_abnormal_axial_skeleton1.15908254
41MP0002127_abnormal_cardiovascular_syste1.14424937
42MP0002932_abnormal_joint_morphology1.13507396
43MP0002822_catalepsy1.11829693
44MP0004484_altered_response_of1.10169556
45MP0006138_congestive_heart_failure1.09645631
46MP0009250_abnormal_appendicular_skeleto1.04999979
47MP0005503_abnormal_tendon_morphology1.04098103
48MP0003385_abnormal_body_wall1.02901716
49MP0003091_abnormal_cell_migration1.01744962
50MP0005385_cardiovascular_system_phenoty0.99898590
51MP0000428_abnormal_craniofacial_morphol0.99857005
52MP0006036_abnormal_mitochondrial_physio0.98039222
53MP0000013_abnormal_adipose_tissue0.97205198
54MP0002972_abnormal_cardiac_muscle0.95017099
55MP0003942_abnormal_urinary_system0.94485288
56MP0003755_abnormal_palate_morphology0.94424722
57MP0003566_abnormal_cell_adhesion0.91524624
58MP0005076_abnormal_cell_differentiation0.91274370
59MP0003279_aneurysm0.89776426
60MP0001661_extended_life_span0.88197025
61MP0003137_abnormal_impulse_conducting0.86981632
62MP0003879_abnormal_hair_cell0.86506928
63MP0003115_abnormal_respiratory_system0.85232409
64MP0005266_abnormal_metabolism0.84404951
65MP0004197_abnormal_fetal_growth/weight/0.83850231
66MP0000767_abnormal_smooth_muscle0.82781570
67MP0004130_abnormal_muscle_cell0.79729964
68MP0000762_abnormal_tongue_morphology0.77743557
69MP0003221_abnormal_cardiomyocyte_apopto0.77117537
70MP0005275_abnormal_skin_tensile0.74801368
71MP0005248_abnormal_Harderian_gland0.73518114
72MP0000534_abnormal_ureter_morphology0.73083373
73MP0002896_abnormal_bone_mineralization0.72664726
74MP0001943_abnormal_respiration0.70660290
75MP0002233_abnormal_nose_morphology0.70514497
76MP0004272_abnormal_basement_membrane0.69708351
77MP0003122_maternal_imprinting0.69299972
78MP0000003_abnormal_adipose_tissue0.68556834
79MP0005508_abnormal_skeleton_morphology0.67581650
80MP0002089_abnormal_postnatal_growth/wei0.66147736
81MP0002184_abnormal_innervation0.65095400
82MP0001849_ear_inflammation0.62839226
83MP0003828_pulmonary_edema0.62420989
84MP0003045_fibrosis0.59924355
85MP0003646_muscle_fatigue0.58896478
86MP0003959_abnormal_lean_body0.58834716
87MP0000537_abnormal_urethra_morphology0.58005504
88MP0004510_myositis0.57521834
89MP0002081_perinatal_lethality0.55990662
90MP0005367_renal/urinary_system_phenotyp0.55154227
91MP0000516_abnormal_urinary_system0.55154227
92MP0009384_cardiac_valve_regurgitation0.55050848
93MP0000462_abnormal_digestive_system0.52746908
94MP0000858_altered_metastatic_potential0.52408279
95MP0000432_abnormal_head_morphology0.52107461
96MP0008775_abnormal_heart_ventricle0.51128929
97MP0003935_abnormal_craniofacial_develop0.51118331
98MP0003948_abnormal_gas_homeostasis0.50316716
99MP0002128_abnormal_blood_circulation0.49677443
100MP0005375_adipose_tissue_phenotype0.48539064
101MP0000955_abnormal_spinal_cord0.48475471
102MP0000266_abnormal_heart_morphology0.48389694
103MP0003011_delayed_dark_adaptation0.48371480
104MP0010368_abnormal_lymphatic_system0.46350523
105MP0000049_abnormal_middle_ear0.45461796
106MP0003567_abnormal_fetal_cardiomyocyte0.45385604
107MP0010352_gastrointestinal_tract_polyps0.44894113
108MP0000163_abnormal_cartilage_morphology0.44491471
109MP0008007_abnormal_cellular_replicative0.44260049
110MP0000678_abnormal_parathyroid_gland0.44167011
111MP0004185_abnormal_adipocyte_glucose0.42927042
112MP0001348_abnormal_lacrimal_gland0.42855901
113MP0005319_abnormal_enzyme/_coenzyme0.42744608
114MP0009672_abnormal_birth_weight0.42533877
115MP0002116_abnormal_craniofacial_bone0.42528419
116MP0005452_abnormal_adipose_tissue0.42090696
117MP0005197_abnormal_uvea_morphology0.41112553
118MP0001915_intracranial_hemorrhage0.40734673
119MP0002332_abnormal_exercise_endurance0.40584133
120MP0002113_abnormal_skeleton_development0.40058777
121MP0004134_abnormal_chest_morphology0.39549536
122MP0001544_abnormal_cardiovascular_syste0.39391547
123MP0004085_abnormal_heartbeat0.38735439
124MP0005666_abnormal_adipose_tissue0.38090710
125MP0002735_abnormal_chemical_nociception0.35739609
126MP0005670_abnormal_white_adipose0.34125407
127MP0001958_emphysema0.33560329
128MP0000467_abnormal_esophagus_morphology0.29462186
129MP0004883_abnormal_blood_vessel0.28854499
130MP0004043_abnormal_pH_regulation0.27036144
131MP0001175_abnormal_lung_morphology0.24602896

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)7.76985126
2Fetal akinesia sequence (HP:0001989)7.75300195
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.87267420
4Type 2 muscle fiber atrophy (HP:0003554)6.78880609
5Amniotic constriction ring (HP:0009775)6.77228287
6Abnormality of placental membranes (HP:0011409)6.77228287
7Malignant hyperthermia (HP:0002047)6.69756662
8Aplasia of the musculature (HP:0100854)6.69201851
9Muscle fiber inclusion bodies (HP:0100299)6.45672910
10Muscle fiber atrophy (HP:0100295)6.19430132
11Distal arthrogryposis (HP:0005684)6.01000034
12Fatigable weakness (HP:0003473)5.93666531
13Abnormality of the neuromuscular junction (HP:0003398)5.93666531
14Round ear (HP:0100830)5.83756108
15Nemaline bodies (HP:0003798)5.77292771
16Ulnar deviation of the wrist (HP:0003049)5.59289032
17Akinesia (HP:0002304)5.47886860
18Weak cry (HP:0001612)5.11051679
19Type 1 muscle fiber predominance (HP:0003803)5.01446238
20Calcaneovalgus deformity (HP:0001848)4.85226927
21Difficulty running (HP:0009046)4.48524937
22Muscle fiber splitting (HP:0003555)4.46992402
23Difficulty climbing stairs (HP:0003551)4.45174384
24Deformed tarsal bones (HP:0008119)4.44754123
25Thin ribs (HP:0000883)4.37630228
26Pterygium (HP:0001059)4.32509156
27Gowers sign (HP:0003391)4.32216656
28Absent phalangeal crease (HP:0006109)4.26819923
29Easy fatigability (HP:0003388)4.20097708
30Aplasia/Hypoplasia involving the musculature (HP:0001460)3.98649650
31Myopathic facies (HP:0002058)3.94885362
32Bulbar palsy (HP:0001283)3.85339185
33Abnormality of the calf musculature (HP:0001430)3.76549721
34Calf muscle hypertrophy (HP:0008981)3.59619884
35Hypoplastic heart (HP:0001961)3.56939851
36Abnormal finger flexion creases (HP:0006143)3.54809720
37Mildly elevated creatine phosphokinase (HP:0008180)3.51621555
38Cystic hygroma (HP:0000476)3.39788241
39EMG: myopathic abnormalities (HP:0003458)3.36846604
40Subaortic stenosis (HP:0001682)3.33841510
41Abnormality of the left ventricular outflow tract (HP:0011103)3.33841510
42Muscle hypertrophy of the lower extremities (HP:0008968)3.31466598
43Distal lower limb amyotrophy (HP:0008944)3.28988898
44Hip contracture (HP:0003273)3.27922531
45Chin dimple (HP:0010751)3.18141170
46Trismus (HP:0000211)3.14705431
47Abnormality of the calcaneus (HP:0008364)3.13278473
48Sudden death (HP:0001699)3.09871818
49Breech presentation (HP:0001623)3.09518284
50Increased connective tissue (HP:0009025)3.09489799
51Rhabdomyolysis (HP:0003201)3.04215480
52Hyporeflexia of lower limbs (HP:0002600)3.04013991
53Distal lower limb muscle weakness (HP:0009053)3.01239984
54Generalized muscle weakness (HP:0003324)2.93667800
55Abnormalities of placenta or umbilical cord (HP:0001194)2.93152701
56Muscle stiffness (HP:0003552)2.81499910
57Abnormality of skeletal muscle fiber size (HP:0012084)2.79052323
58Myoglobinuria (HP:0002913)2.76824990
59Asymmetric septal hypertrophy (HP:0001670)2.76795046
60Diminished movement (HP:0002374)2.63174876
61Short palpebral fissure (HP:0012745)2.58065183
62Lower limb amyotrophy (HP:0007210)2.56566569
63Respiratory insufficiency due to muscle weakness (HP:0002747)2.53571126
64Exercise-induced myalgia (HP:0003738)2.51998059
65Webbed neck (HP:0000465)2.48725295
66Poor suck (HP:0002033)2.42730635
67Depressed nasal tip (HP:0000437)2.38224701
68Increased variability in muscle fiber diameter (HP:0003557)2.37313425
69Nonprogressive disorder (HP:0003680)2.30988196
70Pelvic girdle muscle weakness (HP:0003749)2.30134420
71Rimmed vacuoles (HP:0003805)2.29302958
72Shoulder girdle muscle weakness (HP:0003547)2.29234717
73Limited hip movement (HP:0008800)2.28342316
74Neck muscle weakness (HP:0000467)2.27926529
75Anterior segment dysgenesis (HP:0007700)2.25879605
76Arthrogryposis multiplex congenita (HP:0002804)2.25785365
77Long clavicles (HP:0000890)2.25493549
78Scapular winging (HP:0003691)2.25255154
79Areflexia of lower limbs (HP:0002522)2.24312840
80Abnormality of the musculature of the pelvis (HP:0001469)2.20404213
81Abnormality of the hip-girdle musculature (HP:0001445)2.20404213
82Increased density of long bones (HP:0006392)2.17718506
83Spinal rigidity (HP:0003306)2.16269810
84Metatarsus adductus (HP:0001840)2.15760012
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.14752589
86Mask-like facies (HP:0000298)2.13573601
87Bundle branch block (HP:0011710)2.11136805
88Generalized amyotrophy (HP:0003700)2.08939238
89Hypoplastic ischia (HP:0003175)2.04761127
90Limb-girdle muscle atrophy (HP:0003797)2.04049235
91Abnormal auditory evoked potentials (HP:0006958)2.03354583
92Slender build (HP:0001533)2.02224395
93Exercise-induced muscle cramps (HP:0003710)1.98258949
94Knee flexion contracture (HP:0006380)1.95149599
95Distal upper limb amyotrophy (HP:0007149)1.90167128
96Upper limb amyotrophy (HP:0009129)1.90167128
97Nasal speech (HP:0001611)1.88436769
98Vertebral fusion (HP:0002948)1.86453235
99Neonatal respiratory distress (HP:0002643)1.81179644
100Testicular atrophy (HP:0000029)1.79866591
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79249383
102Proximal amyotrophy (HP:0007126)1.79199048
103Lipoatrophy (HP:0100578)1.78530268
104Symphalangism affecting the phalanges of the hand (HP:0009773)1.78371940
105Myotonia (HP:0002486)1.77015814
106Abnormality of the ischium (HP:0003174)1.75449693
107Frequent falls (HP:0002359)1.75259033
108Facial diplegia (HP:0001349)1.74486846
109Abnormality of the shoulder girdle musculature (HP:0001435)1.73424352
110Dilated cardiomyopathy (HP:0001644)1.72466431
111Limb-girdle muscle weakness (HP:0003325)1.68836611
112Ulnar deviation of finger (HP:0009465)1.64936266
113Progressive muscle weakness (HP:0003323)1.63610708
114Abnormality of the umbilical cord (HP:0010881)1.63268443
115Rocker bottom foot (HP:0001838)1.62823981
116Tarsal synostosis (HP:0008368)1.62733527
117EMG: neuropathic changes (HP:0003445)1.62355036
118Joint contractures involving the joints of the feet (HP:0100492)1.61121192
119Flexion contracture of toe (HP:0005830)1.61121192
120Bell-shaped thorax (HP:0001591)1.58063428
121Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.55184775
122Waddling gait (HP:0002515)1.54890932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.05872281
2PIK3CG4.21066247
3PIM23.19954613
4OBSCN2.99278109
5TTN2.54625670
6MAP3K102.43955837
7MUSK10.9652090
8CDK61.92426975
9ILK1.82219340
10YES11.78950366
11EPHB11.76222322
12PKN21.73616185
13PAK41.70605596
14CCNB11.67697039
15FGFR41.40244438
16AKT21.34382548
17LATS11.30809677
18PTK61.30262356
19MAPK121.19789523
20DDR21.18191779
21EEF2K1.13177268
22DYRK1B1.10698051
23ROCK21.09346508
24* CDK141.03453958
25RIPK11.01938290
26BCKDK1.01915390
27MTOR0.98727400
28LRRK20.97130825
29EPHB20.92311504
30SIK10.91121407
31MAPK110.90611628
32MAP3K70.89400001
33LATS20.88966234
34PINK10.88574972
35* CDK150.88399340
36ICK0.85296425
37PHKG10.85032471
38PHKG20.85032471
39BMX0.84284508
40PTK20.83164401
41LIMK10.82646038
42MAP3K50.82306010
43* CDK180.82302604
44PDGFRA0.82025254
45* CDK11A0.80299341
46CDK70.78391198
47* MOS0.77613232
48NME10.75800307
49FGFR10.73477322
50PAK20.73437580
51ROCK10.72630457
52DMPK0.68866653
53ALK0.68544497
54EPHA20.67130875
55MARK10.64138397
56CAMK2D0.61883972
57MAPKAPK30.60390162
58MAP2K40.60337068
59NEK10.59995831
60KSR20.58531175
61TAOK20.58404685
62MAPK70.56781138
63MARK20.56404659
64MAP3K130.55304077
65FER0.53532077
66MAP2K30.52954748
67DAPK30.52493047
68* MAP2K10.51485200
69ARAF0.51272477
70ERBB30.50545382
71PAK60.49757736
72TRPM70.48320485
73PRPF4B0.42980968
74KSR10.42676399
75RPS6KB20.42420579
76MST1R0.41399116
77CDK80.40066712
78MAPKAPK50.39713727
79TGFBR20.39528471
80ERN10.38166929
81CDK50.37823407
82PAK10.36881457
83PRKAA10.36261220
84DAPK20.36037780
85CAMK40.36011154
86PRKACB0.35571278
87PDK40.35082473
88PDK30.35082473
89PTK2B0.33930007
90CDK190.32242313
91RPS6KA30.31994336
92CAMK2B0.31826702
93MKNK20.31645375
94PRKD30.31408151
95PAK30.31252121
96TYRO30.30629371
97PRKAA20.30156230
98CAMK2A0.30117307
99PBK0.29995813
100MAPK40.29803946
101EPHA30.29773008
102STK110.29592633
103PRKCI0.29323609
104PDPK10.27883008
105PIK3CA0.27697560
106SGK30.26173510
107INSR0.25833710
108MAP2K60.25595293
109STK30.22824071
110PDK20.22800432
111MAPK90.22177189
112MELK0.21915275
113CDK40.21694864
114ERBB40.21584762
115HIPK20.21312357
116CDK90.20751982
117PRKG10.20587725
118PDGFRB0.20422085
119PRKACA0.19320552
120PRKG20.19240168
121TSSK60.18680631
122ABL20.17707883
123NEK90.17103085
124CAMK2G0.17015967
125MAPKAPK20.16602359
126CDK120.16556878
127AKT10.16049907
128BRAF0.15875849
129MKNK10.14399858
130RPS6KA40.14363177
131PDK10.12502930
132CSNK1D0.11944815
133SMG10.11364739
134PKN10.10874856
135RPS6KB10.10624059
136CAMK10.10363847
137CDC42BPA0.10334782
138RPS6KA10.09713873
139RAF10.09457072
140MAP3K10.08830701
141MAPK140.08688941
142VRK20.08422558
143* MAPK100.08349040

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.82337944
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.60709456
3Dilated cardiomyopathy_Homo sapiens_hsa054144.58575649
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.71070312
5Tight junction_Homo sapiens_hsa045302.60210605
6Focal adhesion_Homo sapiens_hsa045102.43847457
7Cardiac muscle contraction_Homo sapiens_hsa042602.40481427
8Proteoglycans in cancer_Homo sapiens_hsa052052.37904411
9Viral myocarditis_Homo sapiens_hsa054162.20168345
10Arginine and proline metabolism_Homo sapiens_hsa003302.05786542
11Chronic myeloid leukemia_Homo sapiens_hsa052201.95743323
12Bladder cancer_Homo sapiens_hsa052191.89773560
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78886704
14Arginine biosynthesis_Homo sapiens_hsa002201.77223933
15ECM-receptor interaction_Homo sapiens_hsa045121.69430037
16Oxytocin signaling pathway_Homo sapiens_hsa049211.64973627
17Adherens junction_Homo sapiens_hsa045201.64191488
18Pentose phosphate pathway_Homo sapiens_hsa000301.55611403
19Insulin signaling pathway_Homo sapiens_hsa049101.51782273
20Pyruvate metabolism_Homo sapiens_hsa006201.45432000
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39800666
22Glucagon signaling pathway_Homo sapiens_hsa049221.38372449
23Glioma_Homo sapiens_hsa052141.34643389
24Hippo signaling pathway_Homo sapiens_hsa043901.34280141
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29869337
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27602627
27Amoebiasis_Homo sapiens_hsa051461.27419025
28mTOR signaling pathway_Homo sapiens_hsa041501.22186830
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21184509
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17036985
31MAPK signaling pathway_Homo sapiens_hsa040101.16052775
32Melanoma_Homo sapiens_hsa052181.14679221
33MicroRNAs in cancer_Homo sapiens_hsa052061.13621925
34Alzheimers disease_Homo sapiens_hsa050101.13240994
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13152120
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.12736317
37Renal cell carcinoma_Homo sapiens_hsa052111.12640985
38TGF-beta signaling pathway_Homo sapiens_hsa043501.12280324
39Prion diseases_Homo sapiens_hsa050201.11815520
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.11196991
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10789198
42Basal cell carcinoma_Homo sapiens_hsa052171.08776067
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08711481
44Parkinsons disease_Homo sapiens_hsa050121.08516971
45HIF-1 signaling pathway_Homo sapiens_hsa040661.06508346
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06227930
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05762259
48Prostate cancer_Homo sapiens_hsa052151.05679416
49FoxO signaling pathway_Homo sapiens_hsa040681.05084186
50Fructose and mannose metabolism_Homo sapiens_hsa000511.04982865
51Axon guidance_Homo sapiens_hsa043601.04692073
52Hedgehog signaling pathway_Homo sapiens_hsa043401.04678125
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01627716
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.98508131
55Dorso-ventral axis formation_Homo sapiens_hsa043200.98392703
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97225152
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96881780
58Sulfur relay system_Homo sapiens_hsa041220.94539497
59Salmonella infection_Homo sapiens_hsa051320.94427165
60AMPK signaling pathway_Homo sapiens_hsa041520.94272308
61Acute myeloid leukemia_Homo sapiens_hsa052210.91903069
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90527396
63Gap junction_Homo sapiens_hsa045400.88499513
64Insulin resistance_Homo sapiens_hsa049310.88270462
65Melanogenesis_Homo sapiens_hsa049160.87334181
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84300825
67Pancreatic cancer_Homo sapiens_hsa052120.82295703
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80025802
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79234514
70ErbB signaling pathway_Homo sapiens_hsa040120.77391975
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.77236288
72Platelet activation_Homo sapiens_hsa046110.77001234
73Biosynthesis of amino acids_Homo sapiens_hsa012300.76482234
74Notch signaling pathway_Homo sapiens_hsa043300.75656605
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74914811
76VEGF signaling pathway_Homo sapiens_hsa043700.73356515
77HTLV-I infection_Homo sapiens_hsa051660.73290450
78Wnt signaling pathway_Homo sapiens_hsa043100.73053080
79Endometrial cancer_Homo sapiens_hsa052130.71288391
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71113600
81Fatty acid degradation_Homo sapiens_hsa000710.70658766
82Small cell lung cancer_Homo sapiens_hsa052220.70458624
83Non-small cell lung cancer_Homo sapiens_hsa052230.70065130
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69966746
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69769966
86GnRH signaling pathway_Homo sapiens_hsa049120.69439220
87p53 signaling pathway_Homo sapiens_hsa041150.69356562
88Renin secretion_Homo sapiens_hsa049240.69045485
89Propanoate metabolism_Homo sapiens_hsa006400.67147862
90Folate biosynthesis_Homo sapiens_hsa007900.64510840
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64101589
92Estrogen signaling pathway_Homo sapiens_hsa049150.63417027
93Starch and sucrose metabolism_Homo sapiens_hsa005000.62664407
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62599404
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62433352
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.61326167
97Carbon metabolism_Homo sapiens_hsa012000.59252167
98Gastric acid secretion_Homo sapiens_hsa049710.59175194
99Pathways in cancer_Homo sapiens_hsa052000.56814382
100Lysine degradation_Homo sapiens_hsa003100.56393950
101Cholinergic synapse_Homo sapiens_hsa047250.56357035
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56106591
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53233554
104Endocytosis_Homo sapiens_hsa041440.52949851
105Circadian rhythm_Homo sapiens_hsa047100.51809664
106Long-term potentiation_Homo sapiens_hsa047200.50010764
107Galactose metabolism_Homo sapiens_hsa000520.49966627
108Rap1 signaling pathway_Homo sapiens_hsa040150.49152158
109Oxidative phosphorylation_Homo sapiens_hsa001900.48827257
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47645270
111B cell receptor signaling pathway_Homo sapiens_hsa046620.46570305
112Colorectal cancer_Homo sapiens_hsa052100.46518039
113Hepatitis B_Homo sapiens_hsa051610.46241874
114beta-Alanine metabolism_Homo sapiens_hsa004100.45968959
115Viral carcinogenesis_Homo sapiens_hsa052030.44166305
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43584991
117One carbon pool by folate_Homo sapiens_hsa006700.42251039
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41723860
119Phenylalanine metabolism_Homo sapiens_hsa003600.41661333
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38734100
121Long-term depression_Homo sapiens_hsa047300.38383437
122Huntingtons disease_Homo sapiens_hsa050160.38303920
123Apoptosis_Homo sapiens_hsa042100.37744216
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35939921
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35367894
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34956529
127Calcium signaling pathway_Homo sapiens_hsa040200.33719417
128Epstein-Barr virus infection_Homo sapiens_hsa051690.31466514
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31318015
130Protein digestion and absorption_Homo sapiens_hsa049740.30179857
131Salivary secretion_Homo sapiens_hsa049700.29177998
132Thyroid cancer_Homo sapiens_hsa052160.29072062
133Fatty acid elongation_Homo sapiens_hsa000620.28593861
134cAMP signaling pathway_Homo sapiens_hsa040240.28343135
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22830130
136Ribosome_Homo sapiens_hsa030100.22563020
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21550417
138Circadian entrainment_Homo sapiens_hsa047130.21482696
139Histidine metabolism_Homo sapiens_hsa003400.21016986
140Nitrogen metabolism_Homo sapiens_hsa009100.18664012

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