

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | skeletal muscle fiber development (GO:0048741) | 9.70294475 |
| 2 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 9.57091705 |
| 3 | actin filament-based movement (GO:0030048) | 8.71137865 |
| 4 | myotube cell development (GO:0014904) | 8.31413099 |
| 5 | striated muscle contraction (GO:0006941) | 6.84659060 |
| 6 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 6.80402862 |
| 7 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 6.75670210 |
| 8 | skeletal muscle adaptation (GO:0043501) | 6.62904393 |
| 9 | muscle cell fate commitment (GO:0042693) | 6.41030607 |
| 10 | sarcomere organization (GO:0045214) | 6.40317126 |
| 11 | response to inactivity (GO:0014854) | 6.40276677 |
| 12 | regulation of actin filament-based movement (GO:1903115) | 5.92524016 |
| 13 | muscle contraction (GO:0006936) | 5.86125640 |
| 14 | positive regulation of myotube differentiation (GO:0010831) | 5.83980782 |
| 15 | striated muscle atrophy (GO:0014891) | 5.82128016 |
| 16 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.78589093 |
| 17 | skeletal muscle tissue regeneration (GO:0043403) | 5.68348874 |
| 18 | cardiac muscle hypertrophy (GO:0003300) | 5.65636502 |
| 19 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.57259324 |
| 20 | cytidine deamination (GO:0009972) | 5.55461523 |
| 21 | cytidine metabolic process (GO:0046087) | 5.55461523 |
| 22 | cytidine catabolic process (GO:0006216) | 5.55461523 |
| 23 | muscle fiber development (GO:0048747) | 5.52035206 |
| 24 | response to muscle activity (GO:0014850) | 5.48586721 |
| 25 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.41776913 |
| 26 | striated muscle hypertrophy (GO:0014897) | 5.36962631 |
| 27 | myofibril assembly (GO:0030239) | 5.35847608 |
| 28 | muscle system process (GO:0003012) | 5.22025769 |
| 29 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 5.18684821 |
| 30 | muscle atrophy (GO:0014889) | 5.08789943 |
| 31 | muscle cell cellular homeostasis (GO:0046716) | 4.89723350 |
| 32 | skeletal muscle tissue development (GO:0007519) | 4.88481641 |
| 33 | myoblast fusion (GO:0007520) | 4.84203293 |
| 34 | muscle hypertrophy (GO:0014896) | 4.82831527 |
| 35 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.77057811 |
| 36 | striated muscle adaptation (GO:0014888) | 4.74268318 |
| 37 | adult heart development (GO:0007512) | 4.70486998 |
| 38 | muscle tissue morphogenesis (GO:0060415) | 4.68209319 |
| 39 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.64837624 |
| 40 | myotube differentiation (GO:0014902) | 4.62491026 |
| 41 | actomyosin structure organization (GO:0031032) | 4.62316473 |
| 42 | regulation of cell communication by electrical coupling (GO:0010649) | 4.61158060 |
| 43 | positive regulation of myoblast differentiation (GO:0045663) | 4.55594744 |
| 44 | regulation of myoblast differentiation (GO:0045661) | 4.50730122 |
| 45 | muscle organ development (GO:0007517) | 4.49676025 |
| 46 | muscle structure development (GO:0061061) | 4.40747107 |
| 47 | NADH metabolic process (GO:0006734) | 4.40293627 |
| 48 | syncytium formation by plasma membrane fusion (GO:0000768) | 4.36459234 |
| 49 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.31675442 |
| 50 | regulation of the force of heart contraction (GO:0002026) | 4.27584293 |
| 51 | creatine metabolic process (GO:0006600) | 4.25542695 |
| 52 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 4.21471966 |
| 53 | striated muscle cell development (GO:0055002) | 4.18854771 |
| 54 | syncytium formation (GO:0006949) | 4.15543531 |
| 55 | regulation of skeletal muscle cell differentiation (GO:2001014) | 4.13685979 |
| 56 | cardiac cell development (GO:0055006) | 4.13523996 |
| 57 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.12470193 |
| 58 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.05770190 |
| 59 | regulation of relaxation of muscle (GO:1901077) | 4.03544529 |
| 60 | glucan biosynthetic process (GO:0009250) | 3.98733559 |
| 61 | glycogen biosynthetic process (GO:0005978) | 3.98733559 |
| 62 | carnitine shuttle (GO:0006853) | 3.95784466 |
| 63 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.93129469 |
| 64 | heart process (GO:0003015) | 3.91385178 |
| 65 | heart contraction (GO:0060047) | 3.91385178 |
| 66 | muscle adaptation (GO:0043500) | 3.89093748 |
| 67 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.86710474 |
| 68 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.78499768 |
| 69 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.75554827 |
| 70 | muscle hypertrophy in response to stress (GO:0003299) | 3.75554827 |
| 71 | cardiac muscle adaptation (GO:0014887) | 3.75554827 |
| 72 | regulation of myotube differentiation (GO:0010830) | 3.74174198 |
| 73 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.70374190 |
| 74 | negative regulation of protein localization to cell surface (GO:2000009) | 3.67015210 |
| 75 | response to caffeine (GO:0031000) | 3.63285880 |
| 76 | cardiac myofibril assembly (GO:0055003) | 3.59920878 |
| 77 | cardiac muscle contraction (GO:0060048) | 3.58523825 |
| 78 | muscle cell development (GO:0055001) | 3.58079955 |
| 79 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.55138542 |
| 80 | regulation of sarcomere organization (GO:0060297) | 3.54611614 |
| 81 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.52224925 |
| 82 | fatty acid transmembrane transport (GO:1902001) | 3.51845746 |
| 83 | regulation of skeletal muscle fiber development (GO:0048742) | 3.51620322 |
| 84 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.50360064 |
| 85 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.50360064 |
| 86 | 2-oxoglutarate metabolic process (GO:0006103) | 3.47515889 |
| 87 | neuromuscular synaptic transmission (GO:0007274) | 3.46413666 |
| 88 | purine nucleotide salvage (GO:0032261) | 3.44556829 |
| 89 | regulation of muscle contraction (GO:0006937) | 3.42563190 |
| 90 | regulation of ATPase activity (GO:0043462) | 3.42243995 |
| 91 | regulation of ATP catabolic process (GO:1903289) | 3.42243995 |
| 92 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.41596693 |
| 93 | positive regulation of cation channel activity (GO:2001259) | 3.40195362 |
| 94 | regulation of sequestering of triglyceride (GO:0010889) | 3.39769601 |
| 95 | skeletal muscle cell differentiation (GO:0035914) | 3.39557488 |
| 96 | glycogen catabolic process (GO:0005980) | 3.38930975 |
| 97 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.36699622 |
| 98 | regulation of heart rate (GO:0002027) | 3.34705349 |
| 99 | positive regulation of skeletal muscle tissue development (GO:0048643) | 3.32595298 |
| 100 | response to activity (GO:0014823) | 3.31885247 |
| 101 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.29318453 |
| 102 | tricarboxylic acid cycle (GO:0006099) | 3.29313312 |
| 103 | regulation of coenzyme metabolic process (GO:0051196) | 3.29214359 |
| 104 | regulation of cofactor metabolic process (GO:0051193) | 3.29214359 |
| 105 | cell communication involved in cardiac conduction (GO:0086065) | 3.23654537 |
| 106 | striated muscle tissue development (GO:0014706) | 3.23528926 |
| 107 | regulation of cardiac muscle contraction (GO:0055117) | 3.23356122 |
| 108 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.23280689 |
| 109 | glucan catabolic process (GO:0009251) | 3.20388014 |
| 110 | regulation of striated muscle contraction (GO:0006942) | 3.19890838 |
| 111 | musculoskeletal movement (GO:0050881) | 3.17572634 |
| 112 | multicellular organismal movement (GO:0050879) | 3.17572634 |
| 113 | negative regulation of muscle hypertrophy (GO:0014741) | 3.12006466 |
| 114 | regulation of p38MAPK cascade (GO:1900744) | 3.10456501 |
| 115 | regulation of membrane repolarization (GO:0060306) | 3.09702679 |
| 116 | neuromuscular junction development (GO:0007528) | 3.08500810 |
| 117 | negative regulation of muscle contraction (GO:0045932) | 3.01956415 |
| 118 | cellular polysaccharide catabolic process (GO:0044247) | 2.96327366 |
| 119 | negative regulation of cAMP-mediated signaling (GO:0043951) | 2.94218611 |
| 120 | polysaccharide catabolic process (GO:0000272) | 2.91594766 |
| 121 | carnitine transmembrane transport (GO:1902603) | 2.90291733 |
| 122 | glycogen metabolic process (GO:0005977) | 2.89373156 |
| 123 | regulation of calcium ion transmembrane transport (GO:1903169) | 2.85640893 |
| 124 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 2.85640893 |
| 125 | muscle tissue development (GO:0060537) | 2.85285216 |
| 126 | glucan metabolic process (GO:0044042) | 2.84629004 |
| 127 | cellular glucan metabolic process (GO:0006073) | 2.84629004 |
| 128 | cardiac muscle cell development (GO:0055013) | 2.84539513 |
| 129 | regulation of muscle system process (GO:0090257) | 2.82925743 |
| 130 | muscle filament sliding (GO:0030049) | 14.0826072 |
| 131 | actin-myosin filament sliding (GO:0033275) | 14.0826072 |
| 132 | skeletal muscle contraction (GO:0003009) | 12.5962790 |
| 133 | actin-mediated cell contraction (GO:0070252) | 11.6475029 |
| 134 | plasma membrane repair (GO:0001778) | 11.2236949 |
| 135 | regulation of skeletal muscle contraction (GO:0014819) | 10.3049768 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.41832590 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.54882834 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.01155949 |
| 4 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.70377940 |
| 5 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.65594532 |
| 6 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.85175385 |
| 7 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.79947960 |
| 8 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.69016503 |
| 9 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.67928153 |
| 10 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.63422941 |
| 11 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.56867212 |
| 12 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 2.45954687 |
| 13 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.44252533 |
| 14 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.44252533 |
| 15 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.21143859 |
| 16 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.08175074 |
| 17 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.06801682 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 1.96657128 |
| 19 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.96028825 |
| 20 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.93003719 |
| 21 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.90134291 |
| 22 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.85183481 |
| 23 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.82258936 |
| 24 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.77798932 |
| 25 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.74549334 |
| 26 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.73589766 |
| 27 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.72887192 |
| 28 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.71906335 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71673642 |
| 30 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.66816739 |
| 31 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.65029410 |
| 32 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.63459398 |
| 33 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.57164955 |
| 34 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.47797533 |
| 35 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.45626824 |
| 36 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.44965909 |
| 37 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.43612758 |
| 38 | CJUN_26792858_Chip-Seq_BT549_Human | 1.35627451 |
| 39 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.33845035 |
| 40 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.32800430 |
| 41 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.31630768 |
| 42 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.30070361 |
| 43 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.25853341 |
| 44 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.25447999 |
| 45 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.24288692 |
| 46 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.23787429 |
| 47 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.21637663 |
| 48 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.21241144 |
| 49 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.19847665 |
| 50 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.18396693 |
| 51 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.17533121 |
| 52 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.16234035 |
| 53 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.16106911 |
| 54 | GATA1_22025678_ChIP-Seq_K562_Human | 1.15157854 |
| 55 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.15077524 |
| 56 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.14602757 |
| 57 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.14167458 |
| 58 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.09659255 |
| 59 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.09560812 |
| 60 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.08270500 |
| 61 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.06747796 |
| 62 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.05539016 |
| 63 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05222034 |
| 64 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.03444331 |
| 65 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.03444331 |
| 66 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.03326389 |
| 67 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.02522635 |
| 68 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.02164876 |
| 69 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.01306297 |
| 70 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.00343762 |
| 71 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.98834625 |
| 72 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.98157773 |
| 73 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.98157773 |
| 74 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.98110057 |
| 75 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.97953714 |
| 76 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97513426 |
| 77 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.96326602 |
| 78 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.95796465 |
| 79 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.95350092 |
| 80 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.95033034 |
| 81 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94770642 |
| 82 | * CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.94578899 |
| 83 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.94574273 |
| 84 | * CTCF_21964334_Chip-Seq_Bcells_Human | 0.94281265 |
| 85 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.93853823 |
| 86 | * SA1_27219007_Chip-Seq_Bcells_Human | 0.93022342 |
| 87 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.92537333 |
| 88 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.91548762 |
| 89 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.90805088 |
| 90 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.90022007 |
| 91 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.89801675 |
| 92 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.89452442 |
| 93 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.89387341 |
| 94 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.89228291 |
| 95 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.88750796 |
| 96 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.88505457 |
| 97 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.88319767 |
| 98 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.87810232 |
| 99 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.87409397 |
| 100 | CBP_21632823_ChIP-Seq_H3396_Human | 0.87283418 |
| 101 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.87216027 |
| 102 | * GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.86766080 |
| 103 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.86436505 |
| 104 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.86436505 |
| 105 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.85651276 |
| 106 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.85415398 |
| 107 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.85101899 |
| 108 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.84397378 |
| 109 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.84257665 |
| 110 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.84255280 |
| 111 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.84148295 |
| 112 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.82860939 |
| 113 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.82416066 |
| 114 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.82281181 |
| 115 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.82056453 |
| 116 | STAT3_23295773_ChIP-Seq_U87_Human | 0.81639033 |
| 117 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.81580849 |
| 118 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.81473510 |
| 119 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.80867439 |
| 120 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.80713624 |
| 121 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.80523296 |
| 122 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80313714 |
| 123 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.79932238 |
| 124 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.79895877 |
| 125 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.79720947 |
| 126 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.79526239 |
| 127 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.79299131 |
| 128 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.78967914 |
| 129 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.78908237 |
| 130 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.78311334 |
| 131 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.78301098 |
| 132 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.77375285 |
| 133 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.77308948 |
| 134 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 0.77277044 |
| 135 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.76885446 |
| 136 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.76490381 |
| 137 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.76406406 |
| 138 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.76379096 |
| 139 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.75995741 |
| 140 | * KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.75650670 |
| 141 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.75278783 |
| 142 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.75270906 |
| 143 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.74780688 |
| 144 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.74592269 |
| 145 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.74198977 |
| 146 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.73705512 |
| 147 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.73227524 |
| 148 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.72645124 |
| 149 | ATF3_27146783_Chip-Seq_COLON_Human | 0.72393723 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000749_muscle_degeneration | 6.73714163 |
| 2 | MP0004145_abnormal_muscle_electrophysio | 6.26731045 |
| 3 | MP0000751_myopathy | 6.23463143 |
| 4 | MP0003646_muscle_fatigue | 5.18243099 |
| 5 | MP0000747_muscle_weakness | 4.57109415 |
| 6 | MP0002106_abnormal_muscle_physiology | 4.10388574 |
| 7 | MP0000750_abnormal_muscle_regeneration | 3.82416656 |
| 8 | MP0000759_abnormal_skeletal_muscle | 3.79914636 |
| 9 | MP0002837_dystrophic_cardiac_calcinosis | 3.71850985 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.61534888 |
| 11 | MP0000733_abnormal_muscle_development | 3.60769390 |
| 12 | MP0005369_muscle_phenotype | 3.50210011 |
| 13 | MP0004036_abnormal_muscle_relaxation | 3.29610722 |
| 14 | MP0002269_muscular_atrophy | 3.17951989 |
| 15 | MP0005620_abnormal_muscle_contractility | 2.80460130 |
| 16 | MP0004270_analgesia | 2.47558216 |
| 17 | MP0004130_abnormal_muscle_cell | 2.43620191 |
| 18 | MP0002108_abnormal_muscle_morphology | 2.39991902 |
| 19 | MP0005330_cardiomyopathy | 2.27581711 |
| 20 | MP0004233_abnormal_muscle_weight | 2.24979651 |
| 21 | MP0004084_abnormal_cardiac_muscle | 2.10254252 |
| 22 | MP0002971_abnormal_brown_adipose | 1.93092551 |
| 23 | MP0000013_abnormal_adipose_tissue | 1.87341392 |
| 24 | MP0004215_abnormal_myocardial_fiber | 1.79301582 |
| 25 | MP0002332_abnormal_exercise_endurance | 1.74905007 |
| 26 | MP0004484_altered_response_of | 1.69845651 |
| 27 | MP0003950_abnormal_plasma_membrane | 1.68692042 |
| 28 | MP0002972_abnormal_cardiac_muscle | 1.62046684 |
| 29 | MP0004185_abnormal_adipocyte_glucose | 1.50141001 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.42948212 |
| 31 | MP0010630_abnormal_cardiac_muscle | 1.34835346 |
| 32 | MP0005666_abnormal_adipose_tissue | 1.30099732 |
| 33 | MP0005275_abnormal_skin_tensile | 1.20463081 |
| 34 | MP0005375_adipose_tissue_phenotype | 1.14109913 |
| 35 | MP0001661_extended_life_span | 1.13797627 |
| 36 | MP0002234_abnormal_pharynx_morphology | 1.05397805 |
| 37 | MP0001544_abnormal_cardiovascular_syste | 1.00449040 |
| 38 | MP0005385_cardiovascular_system_phenoty | 1.00449040 |
| 39 | MP0005266_abnormal_metabolism | 0.94384770 |
| 40 | MP0000003_abnormal_adipose_tissue | 0.93124631 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 0.92179397 |
| 42 | MP0003705_abnormal_hypodermis_morpholog | 0.88756980 |
| 43 | MP0000762_abnormal_tongue_morphology | 0.85545654 |
| 44 | MP0003221_abnormal_cardiomyocyte_apopto | 0.84388039 |
| 45 | MP0005165_increased_susceptibility_to | 0.83944939 |
| 46 | MP0003137_abnormal_impulse_conducting | 0.80260784 |
| 47 | MP0000579_abnormal_nail_morphology | 0.74474719 |
| 48 | MP0009780_abnormal_chondrocyte_physiolo | 0.73979727 |
| 49 | MP0010368_abnormal_lymphatic_system | 0.71957586 |
| 50 | MP0001542_abnormal_bone_strength | 0.71431122 |
| 51 | MP0001299_abnormal_eye_distance/ | 0.69881029 |
| 52 | MP0006138_congestive_heart_failure | 0.68471562 |
| 53 | MP0003941_abnormal_skin_development | 0.66838222 |
| 54 | MP0002249_abnormal_larynx_morphology | 0.65978153 |
| 55 | MP0004134_abnormal_chest_morphology | 0.65116430 |
| 56 | MP0005670_abnormal_white_adipose | 0.64088266 |
| 57 | MP0000372_irregular_coat_pigmentation | 0.62925814 |
| 58 | MP0009250_abnormal_appendicular_skeleto | 0.61631511 |
| 59 | MP0002796_impaired_skin_barrier | 0.61292456 |
| 60 | MP0005503_abnormal_tendon_morphology | 0.59425720 |
| 61 | MP0008775_abnormal_heart_ventricle | 0.59012300 |
| 62 | MP0005167_abnormal_blood-brain_barrier | 0.57959944 |
| 63 | MP0002139_abnormal_hepatobiliary_system | 0.57063460 |
| 64 | MP0005319_abnormal_enzyme/_coenzyme | 0.57016522 |
| 65 | MP0002127_abnormal_cardiovascular_syste | 0.56419605 |
| 66 | MP0008438_abnormal_cutaneous_collagen | 0.55343895 |
| 67 | MP0002128_abnormal_blood_circulation | 0.55067950 |
| 68 | MP0005451_abnormal_body_composition | 0.54958029 |
| 69 | MP0006035_abnormal_mitochondrial_morpho | 0.51572606 |
| 70 | MP0000230_abnormal_systemic_arterial | 0.49399507 |
| 71 | MP0003879_abnormal_hair_cell | 0.48931422 |
| 72 | MP0002638_abnormal_pupillary_reflex | 0.47848272 |
| 73 | MP0000343_altered_response_to | 0.47135779 |
| 74 | MP0004043_abnormal_pH_regulation | 0.47021529 |
| 75 | MP0003828_pulmonary_edema | 0.46757062 |
| 76 | MP0002138_abnormal_hepatobiliary_system | 0.46331825 |
| 77 | MP0005085_abnormal_gallbladder_physiolo | 0.45778549 |
| 78 | MP0000266_abnormal_heart_morphology | 0.45057062 |
| 79 | MP0002078_abnormal_glucose_homeostasis | 0.44337694 |
| 80 | MP0005452_abnormal_adipose_tissue | 0.44274378 |
| 81 | MP0005334_abnormal_fat_pad | 0.44106567 |
| 82 | MP0005501_abnormal_skin_physiology | 0.44072802 |
| 83 | MP0002822_catalepsy | 0.43306964 |
| 84 | MP0002114_abnormal_axial_skeleton | 0.43154640 |
| 85 | MP0010030_abnormal_orbit_morphology | 0.41005527 |
| 86 | MP0002734_abnormal_mechanical_nocicepti | 0.39830153 |
| 87 | MP0003252_abnormal_bile_duct | 0.39725742 |
| 88 | MP0004510_myositis | 0.39485045 |
| 89 | MP0005360_urolithiasis | 0.39393073 |
| 90 | MP0001243_abnormal_dermal_layer | 0.39233457 |
| 91 | MP0003566_abnormal_cell_adhesion | 0.38804746 |
| 92 | MP0005166_decreased_susceptibility_to | 0.38799129 |
| 93 | MP0003656_abnormal_erythrocyte_physiolo | 0.38530121 |
| 94 | MP0006276_abnormal_autonomic_nervous | 0.38428504 |
| 95 | MP0009115_abnormal_fat_cell | 0.37907230 |
| 96 | MP0002060_abnormal_skin_morphology | 0.37348828 |
| 97 | MP0005376_homeostasis/metabolism_phenot | 0.36649431 |
| 98 | MP0001346_abnormal_lacrimal_gland | 0.36281764 |
| 99 | MP0002896_abnormal_bone_mineralization | 0.36009630 |
| 100 | MP0005623_abnormal_meninges_morphology | 0.34714715 |
| 101 | MP0003948_abnormal_gas_homeostasis | 0.34586034 |
| 102 | MP0002254_reproductive_system_inflammat | 0.34372081 |
| 103 | MP0005187_abnormal_penis_morphology | 0.34030335 |
| 104 | MP0003045_fibrosis | 0.32969502 |
| 105 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.31987624 |
| 106 | MP0004147_increased_porphyrin_level | 0.31908503 |
| 107 | MP0001984_abnormal_olfaction | 0.29779566 |
| 108 | MP0001943_abnormal_respiration | 0.29712458 |
| 109 | MP0002118_abnormal_lipid_homeostasis | 0.29254885 |
| 110 | MP0005332_abnormal_amino_acid | 0.29121627 |
| 111 | MP0009384_cardiac_valve_regurgitation | 0.29026446 |
| 112 | MP0000767_abnormal_smooth_muscle | 0.28811941 |
| 113 | MP0008961_abnormal_basal_metabolism | 0.28559308 |
| 114 | MP0008569_lethality_at_weaning | 0.28484437 |
| 115 | MP0004085_abnormal_heartbeat | 0.28473580 |
| 116 | MP0003959_abnormal_lean_body | 0.28251853 |
| 117 | MP0005535_abnormal_body_temperature | 0.28145861 |
| 118 | MP0004142_abnormal_muscle_tone | 0.25813370 |
| 119 | MP0004272_abnormal_basement_membrane | 0.25630188 |
| 120 | MP0003567_abnormal_fetal_cardiomyocyte | 0.20769270 |
| 121 | MP0005386_behavior/neurological_phenoty | 0.20566159 |
| 122 | MP0004924_abnormal_behavior | 0.20566159 |
| 123 | MP0003279_aneurysm | 0.19680681 |
| 124 | MP0005595_abnormal_vascular_smooth | 0.19568254 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Type 1 muscle fiber predominance (HP:0003803) | 8.99552861 |
| 2 | Distal arthrogryposis (HP:0005684) | 7.66966150 |
| 3 | Myopathic facies (HP:0002058) | 6.31646377 |
| 4 | Round ear (HP:0100830) | 6.05514682 |
| 5 | Exercise-induced myalgia (HP:0003738) | 6.01913379 |
| 6 | Ulnar deviation of the wrist (HP:0003049) | 6.00624045 |
| 7 | Calcaneovalgus deformity (HP:0001848) | 5.15106239 |
| 8 | Fetal akinesia sequence (HP:0001989) | 5.07520017 |
| 9 | Muscle hypertrophy of the lower extremities (HP:0008968) | 5.01326896 |
| 10 | Calf muscle hypertrophy (HP:0008981) | 4.91354743 |
| 11 | Muscle fiber splitting (HP:0003555) | 4.87950188 |
| 12 | Exercise-induced muscle cramps (HP:0003710) | 4.86777172 |
| 13 | Deformed tarsal bones (HP:0008119) | 4.75702383 |
| 14 | Malignant hyperthermia (HP:0002047) | 4.67797872 |
| 15 | Absent phalangeal crease (HP:0006109) | 4.60337800 |
| 16 | Bundle branch block (HP:0011710) | 4.60331052 |
| 17 | Hyporeflexia of lower limbs (HP:0002600) | 4.53258178 |
| 18 | Difficulty running (HP:0009046) | 4.41794158 |
| 19 | EMG: myopathic abnormalities (HP:0003458) | 4.39308516 |
| 20 | Abnormality of skeletal muscle fiber size (HP:0012084) | 4.09475953 |
| 21 | Abnormality of the calf musculature (HP:0001430) | 3.97002534 |
| 22 | Abnormal finger flexion creases (HP:0006143) | 3.86901934 |
| 23 | Neck muscle weakness (HP:0000467) | 3.84226213 |
| 24 | Ventricular tachycardia (HP:0004756) | 3.81976545 |
| 25 | Popliteal pterygium (HP:0009756) | 3.80168712 |
| 26 | Abnormality of the neuromuscular junction (HP:0003398) | 3.73798572 |
| 27 | Fatigable weakness (HP:0003473) | 3.73798572 |
| 28 | Increased connective tissue (HP:0009025) | 3.73636165 |
| 29 | Weak cry (HP:0001612) | 3.55480715 |
| 30 | Bulbar palsy (HP:0001283) | 3.49229294 |
| 31 | Frequent falls (HP:0002359) | 3.42356210 |
| 32 | Lipoatrophy (HP:0100578) | 3.40687743 |
| 33 | Abnormality of placental membranes (HP:0011409) | 3.40122610 |
| 34 | Amniotic constriction ring (HP:0009775) | 3.40122610 |
| 35 | Type 2 muscle fiber atrophy (HP:0003554) | 3.33971940 |
| 36 | Increased variability in muscle fiber diameter (HP:0003557) | 3.32557607 |
| 37 | Dilated cardiomyopathy (HP:0001644) | 3.32336274 |
| 38 | Aplasia of the musculature (HP:0100854) | 3.23832499 |
| 39 | Difficulty climbing stairs (HP:0003551) | 3.22579079 |
| 40 | Hip contracture (HP:0003273) | 3.22226593 |
| 41 | Myoglobinuria (HP:0002913) | 3.11376855 |
| 42 | Gowers sign (HP:0003391) | 3.11374109 |
| 43 | Mildly elevated creatine phosphokinase (HP:0008180) | 3.11032120 |
| 44 | Abnormality of the calcaneus (HP:0008364) | 3.04490399 |
| 45 | Muscle stiffness (HP:0003552) | 3.04056457 |
| 46 | Slender build (HP:0001533) | 2.99569579 |
| 47 | Muscle fiber atrophy (HP:0100295) | 2.97099264 |
| 48 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.89724602 |
| 49 | Heart block (HP:0012722) | 2.85714574 |
| 50 | Rimmed vacuoles (HP:0003805) | 2.84890145 |
| 51 | Generalized muscle weakness (HP:0003324) | 2.83287542 |
| 52 | Areflexia of lower limbs (HP:0002522) | 2.79967111 |
| 53 | Myotonia (HP:0002486) | 2.77291544 |
| 54 | Atrial fibrillation (HP:0005110) | 2.73396725 |
| 55 | Abnormal atrioventricular conduction (HP:0005150) | 2.67513597 |
| 56 | Distal lower limb muscle weakness (HP:0009053) | 2.63600080 |
| 57 | Akinesia (HP:0002304) | 2.61363297 |
| 58 | Ventricular arrhythmia (HP:0004308) | 2.60532655 |
| 59 | Facial diplegia (HP:0001349) | 2.60106957 |
| 60 | Syncope (HP:0001279) | 2.59373736 |
| 61 | Right ventricular cardiomyopathy (HP:0011663) | 2.55870786 |
| 62 | Rhabdomyolysis (HP:0003201) | 2.53807747 |
| 63 | EMG: neuropathic changes (HP:0003445) | 2.52793915 |
| 64 | Distal lower limb amyotrophy (HP:0008944) | 2.50308740 |
| 65 | Spinal rigidity (HP:0003306) | 2.48579166 |
| 66 | Primary atrial arrhythmia (HP:0001692) | 2.47793464 |
| 67 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.46890607 |
| 68 | Subaortic stenosis (HP:0001682) | 2.46890607 |
| 69 | Progressive muscle weakness (HP:0003323) | 2.45549283 |
| 70 | Scapular winging (HP:0003691) | 2.43884338 |
| 71 | Easy fatigability (HP:0003388) | 2.38473108 |
| 72 | Supraventricular tachycardia (HP:0004755) | 2.37538480 |
| 73 | Abnormality of the foot musculature (HP:0001436) | 2.36893904 |
| 74 | Pelvic girdle muscle weakness (HP:0003749) | 2.33597533 |
| 75 | Shoulder girdle muscle weakness (HP:0003547) | 2.32583018 |
| 76 | Supraventricular arrhythmia (HP:0005115) | 2.30599985 |
| 77 | Sudden death (HP:0001699) | 2.29227114 |
| 78 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.25021036 |
| 79 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.25021036 |
| 80 | Limited hip movement (HP:0008800) | 2.21163044 |
| 81 | Asymmetric septal hypertrophy (HP:0001670) | 2.20843009 |
| 82 | Metatarsus adductus (HP:0001840) | 2.17454829 |
| 83 | Proximal amyotrophy (HP:0007126) | 2.14532853 |
| 84 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 2.11314178 |
| 85 | Foot dorsiflexor weakness (HP:0009027) | 2.10501333 |
| 86 | Ragged-red muscle fibers (HP:0003200) | 2.08945026 |
| 87 | Breech presentation (HP:0001623) | 2.08591505 |
| 88 | Ulnar deviation of finger (HP:0009465) | 2.08331469 |
| 89 | Ventricular fibrillation (HP:0001663) | 2.07525532 |
| 90 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.02833734 |
| 91 | Muscle fiber inclusion bodies (HP:0100299) | 11.5111353 |
| 92 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 10.8983498 |
| 93 | Nemaline bodies (HP:0003798) | 10.7298848 |
| 94 | Waddling gait (HP:0002515) | 1.98238564 |
| 95 | Trismus (HP:0000211) | 1.97987723 |
| 96 | Atrioventricular block (HP:0001678) | 1.97563523 |
| 97 | Palpitations (HP:0001962) | 1.97235863 |
| 98 | Limb-girdle muscle atrophy (HP:0003797) | 1.92387138 |
| 99 | Thin ribs (HP:0000883) | 1.91841827 |
| 100 | Nonprogressive disorder (HP:0003680) | 1.90285129 |
| 101 | Long clavicles (HP:0000890) | 1.89231054 |
| 102 | Pterygium (HP:0001059) | 1.87693512 |
| 103 | Muscular dystrophy (HP:0003560) | 1.87299609 |
| 104 | Left ventricular hypertrophy (HP:0001712) | 1.86088411 |
| 105 | Lower limb amyotrophy (HP:0007210) | 1.85286541 |
| 106 | Hypoplastic heart (HP:0001961) | 1.84740080 |
| 107 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.81644652 |
| 108 | Steppage gait (HP:0003376) | 1.76663659 |
| 109 | Hypoplastic ischia (HP:0003175) | 1.74803546 |
| 110 | Hyperkalemia (HP:0002153) | 1.72632536 |
| 111 | Ulnar deviation of the hand or of fingers of the hand (HP:0001193) | 1.72021678 |
| 112 | Limb-girdle muscle weakness (HP:0003325) | 1.70714755 |
| 113 | Prolonged QT interval (HP:0001657) | 1.68843619 |
| 114 | Tarsal synostosis (HP:0008368) | 1.67666548 |
| 115 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.61067786 |
| 116 | Cystic hygroma (HP:0000476) | 1.56776593 |
| 117 | Arthrogryposis multiplex congenita (HP:0002804) | 1.55331815 |
| 118 | Webbed neck (HP:0000465) | 1.54861715 |
| 119 | Synostosis involving bones of the feet (HP:0009140) | 1.53685002 |
| 120 | Synostosis involving bones of the lower limbs (HP:0009138) | 1.53685002 |
| 121 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.53408447 |
| 122 | Exercise intolerance (HP:0003546) | 1.51948226 |
| 123 | Paralysis (HP:0003470) | 1.51196303 |
| 124 | Abnormal EKG (HP:0003115) | 1.51010900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PIK3CG | 5.69334211 |
| 2 | TTN | 4.71332591 |
| 3 | MUSK | 3.64000067 |
| 4 | PHKG2 | 2.64111890 |
| 5 | PHKG1 | 2.64111890 |
| 6 | NME1 | 2.62944747 |
| 7 | TRIB3 | 2.57024840 |
| 8 | MAP2K3 | 2.12046531 |
| 9 | OBSCN | 11.4698136 |
| 10 | MYLK | 1.93712150 |
| 11 | MOS | 1.92247492 |
| 12 | PINK1 | 1.83047734 |
| 13 | MAP3K7 | 1.71774858 |
| 14 | DMPK | 1.65676648 |
| 15 | PDK3 | 1.62442661 |
| 16 | PDK4 | 1.62442661 |
| 17 | MAPK12 | 1.54741635 |
| 18 | NEK1 | 1.50277516 |
| 19 | MARK1 | 1.26039684 |
| 20 | PDK2 | 1.24078016 |
| 21 | AKT2 | 1.12862509 |
| 22 | MAP3K3 | 1.03388391 |
| 23 | PKN2 | 1.02449095 |
| 24 | MAP2K4 | 0.94920271 |
| 25 | MAPKAPK3 | 0.91501432 |
| 26 | MAP2K6 | 0.89490065 |
| 27 | BCKDK | 0.87510380 |
| 28 | TAOK2 | 0.81502131 |
| 29 | FRK | 0.78470204 |
| 30 | CAMK4 | 0.72896337 |
| 31 | ZAK | 0.72506645 |
| 32 | MAP2K1 | 0.71975891 |
| 33 | PIM2 | 0.71709108 |
| 34 | PAK3 | 0.71246942 |
| 35 | EPHB1 | 0.70531595 |
| 36 | MAPK11 | 0.70457967 |
| 37 | PIK3CA | 0.70233649 |
| 38 | STK24 | 0.59599183 |
| 39 | NEK9 | 0.58654145 |
| 40 | CAMK1 | 0.55257935 |
| 41 | MAP3K5 | 0.55078311 |
| 42 | TRPM7 | 0.54509590 |
| 43 | ILK | 0.50872400 |
| 44 | CAMK2G | 0.49417040 |
| 45 | CAMK2B | 0.48756928 |
| 46 | PRKAA1 | 0.48307076 |
| 47 | LATS1 | 0.48282911 |
| 48 | INSRR | 0.47967799 |
| 49 | RIPK1 | 0.47743543 |
| 50 | ERBB3 | 0.47501924 |
| 51 | SIK1 | 0.46800010 |
| 52 | EPHA3 | 0.45171856 |
| 53 | SGK2 | 0.43317430 |
| 54 | LIMK1 | 0.43219840 |
| 55 | ROCK1 | 0.42597350 |
| 56 | PRKAA2 | 0.42038640 |
| 57 | ERN1 | 0.41673841 |
| 58 | TAOK1 | 0.39493902 |
| 59 | MAPK7 | 0.38429077 |
| 60 | PTK6 | 0.37842062 |
| 61 | MAP3K10 | 0.37206679 |
| 62 | CDK6 | 0.37203326 |
| 63 | MARK3 | 0.35940932 |
| 64 | MAPK13 | 0.33563901 |
| 65 | MAP3K11 | 0.33124703 |
| 66 | PRKG1 | 0.32656007 |
| 67 | GRK7 | 0.32516121 |
| 68 | RPS6KL1 | 0.31332795 |
| 69 | RPS6KC1 | 0.31332795 |
| 70 | RPS6KA6 | 0.30963936 |
| 71 | TGFBR2 | 0.30432092 |
| 72 | MAPK4 | 0.29278186 |
| 73 | DYRK1B | 0.27209539 |
| 74 | ICK | 0.26513427 |
| 75 | CDC42BPA | 0.26305982 |
| 76 | STK38L | 0.25893113 |
| 77 | FLT3 | 0.25876193 |
| 78 | RPS6KA1 | 0.25276898 |
| 79 | PTK2B | 0.24551517 |
| 80 | SGK1 | 0.23994964 |
| 81 | SGK494 | 0.23780495 |
| 82 | SGK223 | 0.23780495 |
| 83 | PRKCE | 0.23591334 |
| 84 | RPS6KB1 | 0.23179172 |
| 85 | PDPK1 | 0.22388741 |
| 86 | FGFR4 | 0.21387920 |
| 87 | MAP3K6 | 0.21306892 |
| 88 | RPS6KA3 | 0.21152633 |
| 89 | MST1R | 0.20511465 |
| 90 | EEF2K | 0.20331176 |
| 91 | KSR2 | 0.19876258 |
| 92 | PDGFRA | 0.19708996 |
| 93 | PKN1 | 0.19377671 |
| 94 | PRKG2 | 0.19141052 |
| 95 | NLK | 0.18031962 |
| 96 | PRKACB | 0.18031577 |
| 97 | LATS2 | 0.17591758 |
| 98 | PDK1 | 0.16685283 |
| 99 | MAP3K13 | 0.16497223 |
| 100 | STK4 | 0.16018997 |
| 101 | RPS6KB2 | 0.15041490 |
| 102 | PRKACA | 0.14598560 |
| 103 | TBK1 | 0.13919473 |
| 104 | STK11 | 0.13514706 |
| 105 | TIE1 | 0.12641301 |
| 106 | CAMK2A | 0.12135153 |
| 107 | BMX | 0.12083164 |
| 108 | MARK2 | 0.11798463 |
| 109 | EPHB2 | 0.11620873 |
| 110 | SGK3 | 0.11488809 |
| 111 | WNK1 | 0.11382226 |
| 112 | PAK4 | 0.11128480 |
| 113 | TNIK | 0.11066270 |
| 114 | BMPR1B | 0.10924832 |
| 115 | DDR2 | 0.10482355 |
| 116 | FER | 0.09557516 |
| 117 | CDK14 | 0.09145825 |
| 118 | CDK15 | 0.09113279 |
| 119 | PRKD1 | 0.08506824 |
| 120 | DAPK2 | 0.08467446 |
| 121 | ROCK2 | 0.07765886 |
| 122 | CDK18 | 0.07753929 |
| 123 | CDK11A | 0.06883716 |
| 124 | MTOR | 0.05814262 |
| 125 | MAPK10 | 0.05712507 |
| 126 | MAP3K1 | 0.05244758 |
| 127 | MAPKAPK2 | 0.03958213 |
| 128 | CAMK2D | 0.03806094 |
| 129 | CDK8 | 0.03717129 |
| 130 | FGFR3 | 0.03094332 |
| 131 | ABL1 | 0.01783411 |
| 132 | CCNB1 | 0.01110723 |
| 133 | PRKACG | 0.00867168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 4.50729844 |
| 2 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 4.00403475 |
| 3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.99007942 |
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 3.84882578 |
| 5 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.52322658 |
| 6 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.45928327 |
| 7 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.19352037 |
| 8 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.66138347 |
| 9 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.46103954 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.30486035 |
| 11 | Carbon metabolism_Homo sapiens_hsa01200 | 1.99245034 |
| 12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.83556196 |
| 13 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.69121767 |
| 14 | Tight junction_Homo sapiens_hsa04530 | 1.68491690 |
| 15 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.63762945 |
| 16 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.61874250 |
| 17 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.60370499 |
| 18 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.56815762 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.55601346 |
| 20 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.55596239 |
| 21 | Insulin resistance_Homo sapiens_hsa04931 | 1.48766027 |
| 22 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.39362343 |
| 23 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.39211076 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33735270 |
| 25 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.29148493 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28468772 |
| 27 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.14950661 |
| 28 | Galactose metabolism_Homo sapiens_hsa00052 | 1.08597438 |
| 29 | Focal adhesion_Homo sapiens_hsa04510 | 1.06759404 |
| 30 | Circadian rhythm_Homo sapiens_hsa04710 | 1.05725023 |
| 31 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.03862180 |
| 32 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.03794304 |
| 33 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.03144988 |
| 34 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.96499485 |
| 35 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.96024382 |
| 36 | Alzheimers disease_Homo sapiens_hsa05010 | 0.94863642 |
| 37 | Parkinsons disease_Homo sapiens_hsa05012 | 0.94647990 |
| 38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.94135018 |
| 39 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.94038646 |
| 40 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.93760858 |
| 41 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.92197443 |
| 42 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89301989 |
| 43 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.87022151 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.85498759 |
| 45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83794712 |
| 46 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.79480196 |
| 47 | Circadian entrainment_Homo sapiens_hsa04713 | 0.76543049 |
| 48 | Salivary secretion_Homo sapiens_hsa04970 | 0.75841657 |
| 49 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.73985911 |
| 50 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.72939666 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.69049390 |
| 52 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.67266710 |
| 53 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.65113000 |
| 54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.64289202 |
| 55 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.63707730 |
| 56 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.63586757 |
| 57 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.62812134 |
| 58 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.59283664 |
| 59 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.58091757 |
| 60 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.57937460 |
| 61 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.56763336 |
| 62 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.56351687 |
| 63 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.54968537 |
| 64 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.54522396 |
| 65 | Amoebiasis_Homo sapiens_hsa05146 | 0.52151043 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.52128730 |
| 67 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.51058854 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.50527838 |
| 69 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.48059316 |
| 70 | Olfactory transduction_Homo sapiens_hsa04740 | 0.47881943 |
| 71 | Huntingtons disease_Homo sapiens_hsa05016 | 0.46060694 |
| 72 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45555238 |
| 73 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.45193966 |
| 74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.44336377 |
| 75 | Phototransduction_Homo sapiens_hsa04744 | 0.43185358 |
| 76 | Bile secretion_Homo sapiens_hsa04976 | 0.41951738 |
| 77 | Long-term potentiation_Homo sapiens_hsa04720 | 0.41777049 |
| 78 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.40967851 |
| 79 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.40796166 |
| 80 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.40740663 |
| 81 | Histidine metabolism_Homo sapiens_hsa00340 | 0.39643473 |
| 82 | ABC transporters_Homo sapiens_hsa02010 | 0.39264773 |
| 83 | Adherens junction_Homo sapiens_hsa04520 | 0.39249764 |
| 84 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.39222477 |
| 85 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.39138982 |
| 86 | Renin secretion_Homo sapiens_hsa04924 | 0.38973363 |
| 87 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37895289 |
| 88 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.37827470 |
| 89 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.37647578 |
| 90 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.37517278 |
| 91 | Platelet activation_Homo sapiens_hsa04611 | 0.35537502 |
| 92 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.35229347 |
| 93 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.34644846 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.33335216 |
| 95 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.32732436 |
| 96 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.32285328 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32103736 |
| 98 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.29307668 |
| 99 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.29227134 |
| 100 | Insulin secretion_Homo sapiens_hsa04911 | 0.28751134 |
| 101 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.28324095 |
| 102 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.28157702 |
| 103 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.27656639 |
| 104 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26320828 |
| 105 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.25322413 |
| 106 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.25222988 |
| 107 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.25080336 |
| 108 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.24261861 |
| 109 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.22421233 |
| 110 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.22268923 |
| 111 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.21982041 |
| 112 | Long-term depression_Homo sapiens_hsa04730 | 0.19827223 |
| 113 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.19404904 |
| 114 | Lysine degradation_Homo sapiens_hsa00310 | 0.18293703 |
| 115 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.17257488 |
| 116 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.16757260 |
| 117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.16631707 |
| 118 | Mineral absorption_Homo sapiens_hsa04978 | 0.13740633 |
| 119 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.12797028 |
| 120 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.11283571 |
| 121 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.11237957 |
| 122 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.10679402 |
| 123 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.10574499 |
| 124 | Bladder cancer_Homo sapiens_hsa05219 | 0.10413162 |
| 125 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.09975960 |

