MYOT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)9.17240142
2plasma membrane repair (GO:0001778)8.29170523
3actin filament-based movement (GO:0030048)7.81173748
4skeletal muscle fiber development (GO:0048741)7.35713228
5sarcomere organization (GO:0045214)7.08679487
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.97189440
7striated muscle contraction (GO:0006941)6.74317965
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.53664621
9myofibril assembly (GO:0030239)6.32163596
10myotube cell development (GO:0014904)6.28783692
11creatine metabolic process (GO:0006600)6.28383775
12glycogen catabolic process (GO:0005980)6.04968273
13skeletal muscle tissue regeneration (GO:0043403)6.00596446
14carnitine shuttle (GO:0006853)5.91843593
15pyrimidine ribonucleoside catabolic process (GO:0046133)5.79584293
16regulation of cell communication by electrical coupling (GO:0010649)5.78087733
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.77923510
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.73144107
19glucan catabolic process (GO:0009251)5.66197045
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.63505173
21striated muscle atrophy (GO:0014891)5.61945170
22cytidine catabolic process (GO:0006216)5.60971353
23cytidine deamination (GO:0009972)5.60971353
24cytidine metabolic process (GO:0046087)5.60971353
25response to muscle activity (GO:0014850)5.44832511
26* muscle contraction (GO:0006936)5.44736699
27response to inactivity (GO:0014854)5.36123057
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.32120055
29cellular polysaccharide catabolic process (GO:0044247)5.26816942
30striated muscle adaptation (GO:0014888)5.06435120
31polysaccharide catabolic process (GO:0000272)5.02523100
32fatty acid transmembrane transport (GO:1902001)5.02108329
33purine nucleotide salvage (GO:0032261)5.00542785
34actomyosin structure organization (GO:0031032)4.90214714
35muscle atrophy (GO:0014889)4.87219478
36glucan biosynthetic process (GO:0009250)4.87194263
37glycogen biosynthetic process (GO:0005978)4.87194263
38* muscle system process (GO:0003012)4.85628228
39regulation of acyl-CoA biosynthetic process (GO:0050812)4.85121971
40NADH metabolic process (GO:0006734)4.84233942
41muscle fiber development (GO:0048747)4.82295888
42regulation of relaxation of muscle (GO:1901077)4.79646437
43cardiac muscle hypertrophy (GO:0003300)4.78154029
44negative regulation of potassium ion transmembrane transport (GO:1901380)4.46452319
45carnitine transmembrane transport (GO:1902603)4.38538130
46regulation of cofactor metabolic process (GO:0051193)4.38134676
47regulation of coenzyme metabolic process (GO:0051196)4.38134676
48cardiac muscle contraction (GO:0060048)4.37984438
49IMP metabolic process (GO:0046040)4.34299488
50tricarboxylic acid cycle (GO:0006099)4.27119349
51fructose metabolic process (GO:0006000)4.21999036
52glycogen metabolic process (GO:0005977)4.19735218
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.19503922
54muscle cell fate commitment (GO:0042693)4.13764037
55muscle adaptation (GO:0043500)4.12698670
56positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.11772298
57cellular glucan metabolic process (GO:0006073)4.11273114
58glucan metabolic process (GO:0044042)4.11273114
59cardiac myofibril assembly (GO:0055003)4.10724798
60muscle hypertrophy (GO:0014896)4.07511825
61carnitine transport (GO:0015879)4.00175537
62amino-acid betaine transport (GO:0015838)4.00175537
63muscle organ morphogenesis (GO:0048644)3.95330518
64negative regulation of muscle hypertrophy (GO:0014741)3.92110641
65muscle tissue morphogenesis (GO:0060415)3.92016583
66myoblast fusion (GO:0007520)3.89843832
67gluconeogenesis (GO:0006094)3.88519349
68regulation of skeletal muscle cell differentiation (GO:2001014)3.83968022
69striated muscle cell development (GO:0055002)3.83357769
70response to activity (GO:0014823)3.83071179
71muscle organ development (GO:0007517)3.78298323
72adult heart development (GO:0007512)3.78054280
73muscle structure development (GO:0061061)3.74084393
74cardiac muscle tissue morphogenesis (GO:0055008)3.72845849
75muscle cell cellular homeostasis (GO:0046716)3.72469547
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.67991777
77heart contraction (GO:0060047)3.66387087
78heart process (GO:0003015)3.66387087
79negative regulation of calcium ion transmembrane transport (GO:1903170)3.61267797
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.61267797
81regulation of actin filament-based movement (GO:1903115)3.61208281
82regulation of sulfur metabolic process (GO:0042762)3.57961152
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57512437
84cellular response to dexamethasone stimulus (GO:0071549)3.54841792
85regulation of calcium ion transmembrane transporter activity (GO:1901019)3.54821885
86regulation of calcium ion transmembrane transport (GO:1903169)3.54821885
87negative regulation of skeletal muscle tissue development (GO:0048642)3.52844148
88regulation of striated muscle contraction (GO:0006942)3.52666320
89negative regulation of muscle contraction (GO:0045932)3.50241236
90cardiac muscle cell development (GO:0055013)3.49644134
91hexose biosynthetic process (GO:0019319)3.47741387
92skeletal muscle tissue development (GO:0007519)3.44125990
93positive regulation of myoblast differentiation (GO:0045663)3.44048010
94striated muscle tissue development (GO:0014706)3.43249905
95syncytium formation by plasma membrane fusion (GO:0000768)3.41052693
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.40588482
97cardiac muscle hypertrophy in response to stress (GO:0014898)3.39850175
98muscle hypertrophy in response to stress (GO:0003299)3.39850175
99cardiac muscle adaptation (GO:0014887)3.39850175
100myotube differentiation (GO:0014902)3.39683549
101negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.38522192
102ubiquinone biosynthetic process (GO:0006744)3.36710328
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.35603183
104neuronal action potential propagation (GO:0019227)3.32834470
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.32258984
106cellular carbohydrate catabolic process (GO:0044275)3.31100307
107positive regulation of myotube differentiation (GO:0010831)3.30979788
108response to dexamethasone (GO:0071548)3.30124095
109relaxation of muscle (GO:0090075)3.30022534
110IMP biosynthetic process (GO:0006188)3.27865489
111muscle cell development (GO:0055001)3.26176071
112cardiac cell development (GO:0055006)3.25775955
113negative regulation of cAMP-mediated signaling (GO:0043951)3.24224955
114neuromuscular synaptic transmission (GO:0007274)3.15936084
115regulation of membrane repolarization (GO:0060306)3.13840998
1162-oxoglutarate metabolic process (GO:0006103)3.06757352
117striated muscle hypertrophy (GO:0014897)3.04209144
118regulation of sequestering of triglyceride (GO:0010889)3.02581291
119regulation of myoblast differentiation (GO:0045661)3.00902946
120muscle filament sliding (GO:0030049)12.7566623
121actin-myosin filament sliding (GO:0033275)12.7566623
122regulation of skeletal muscle contraction (GO:0014819)11.5935981
123skeletal muscle contraction (GO:0003009)10.7430205
124actin-mediated cell contraction (GO:0070252)10.4634936
125sarcoplasmic reticulum calcium ion transport (GO:0070296)10.3613910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.62339281
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94418256
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.64668673
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.55467956
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.17151521
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13611096
7* TBX20_22080862_ChIP-Seq_HEART_Mouse2.85036586
8* TBX20_22328084_ChIP-Seq_HEART_Mouse2.85036586
9ZNF263_19887448_ChIP-Seq_K562_Human2.71883257
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51404149
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50363357
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39125812
13BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.33418061
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25748716
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.07327584
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.99122990
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88763059
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81716850
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78746904
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73395369
21CTCF_27219007_Chip-Seq_Bcells_Human1.70834491
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.68791115
23CTCF_21964334_ChIP-Seq_BJAB-B_Human1.67390246
24ZNF274_21170338_ChIP-Seq_K562_Hela1.67380127
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.65763901
26AR_21572438_ChIP-Seq_LNCaP_Human1.65404969
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64087624
28EZH2_22144423_ChIP-Seq_EOC_Human1.63114960
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59911902
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53565199
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53090394
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51548609
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49885216
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47449379
35IGF1R_20145208_ChIP-Seq_DFB_Human1.40580239
36CLOCK_20551151_ChIP-Seq_293T_Human1.37556249
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37264832
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33329278
39FOXH1_21741376_ChIP-Seq_ESCs_Human1.32896594
40GATA4_21415370_ChIP-Seq_HL-1_Mouse1.32876585
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31842145
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29846711
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28262663
44SA1_27219007_Chip-Seq_Bcells_Human1.28141403
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24820962
46OCT4_20526341_ChIP-Seq_ESCs_Human1.23610354
47CTCF_21964334_Chip-Seq_Bcells_Human1.20203883
48DROSHA_22980978_ChIP-Seq_HELA_Human1.19417496
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18520608
50KDM2B_26808549_Chip-Seq_DND41_Human1.17341826
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14755202
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.14280048
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12844927
54RACK7_27058665_Chip-Seq_MCF-7_Human1.12659535
55SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11445628
56STAT1_20625510_ChIP-Seq_HELA_Human1.10950247
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.10111816
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09866474
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.09439884
60SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07545830
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.07036315
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07001552
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05999100
64GBX2_23144817_ChIP-Seq_PC3_Human1.05610461
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04554450
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04241909
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04225575
68CBP_20019798_ChIP-Seq_JUKART_Human1.04225575
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02942076
70CREB1_26743006_Chip-Seq_LNCaP_Human1.00948377
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00702679
72NANOG_20526341_ChIP-Seq_ESCs_Human1.00646243
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.00493616
74P68_20966046_ChIP-Seq_HELA_Human0.99542685
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.99473025
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97688516
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97621295
78RXR_22158963_ChIP-Seq_LIVER_Mouse0.96887854
79PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96676889
80OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96436318
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96045389
82CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95745752
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95622543
84LXR_22292898_ChIP-Seq_THP-1_Human0.95591056
85SPI1_20517297_ChIP-Seq_HL60_Human0.95232702
86CJUN_26792858_Chip-Seq_BT549_Human0.94556932
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94466022
88HTT_18923047_ChIP-ChIP_STHdh_Human0.93943401
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93855332
90RAC3_21632823_ChIP-Seq_H3396_Human0.93767356
91ATF3_27146783_Chip-Seq_COLON_Human0.92787371
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91921542
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90873613
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90517949
95CEBPB_22108803_ChIP-Seq_LS180_Human0.90203948
96MYC_27129775_Chip-Seq_CORNEA_Mouse0.89838834
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88836360
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88836360
99* TP63_22573176_ChIP-Seq_HFKS_Human0.88629974
100E2F1_20622854_ChIP-Seq_HELA_Human0.88507145
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86864782
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86788845
103BCL6_27268052_Chip-Seq_Bcells_Human0.86660316
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86095984
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.86001730
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85713067
107GATA6_21074721_ChIP-Seq_CACO-2_Human0.85666506
108EZH2_27294783_Chip-Seq_ESCs_Mouse0.85049395
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.84724669
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.84696913
111P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84648895
112TCF7_22412390_ChIP-Seq_EML_Mouse0.84228233
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.84141194
114GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83428487
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.82882885
116ER_23166858_ChIP-Seq_MCF-7_Human0.82764672
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82649013
118CBP_21632823_ChIP-Seq_H3396_Human0.82584351
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82569158
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.82420210
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82071767
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81830746
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81652184
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81453935
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81421051
126PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80855056
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80853994
128OCT1_27270436_Chip-Seq_PROSTATE_Human0.80604849
129NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80160943
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79811638
131* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78400989
132CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76161259
133GATA1_22025678_ChIP-Seq_K562_Human0.74439981
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.73929986
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71862067
136NANOG_19829295_ChIP-Seq_ESCs_Human0.71734669
137SOX2_19829295_ChIP-Seq_ESCs_Human0.71734669
138EGR1_19032775_ChIP-ChIP_M12_Human0.70475509
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69663831
140GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.69117320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.34979442
2MP0003646_muscle_fatigue6.57367495
3MP0000749_muscle_degeneration6.22337847
4MP0000751_myopathy5.84497372
5MP0000747_muscle_weakness4.29945453
6MP0002837_dystrophic_cardiac_calcinosis4.11970275
7MP0002106_abnormal_muscle_physiology4.11479855
8MP0004036_abnormal_muscle_relaxation4.07917463
9MP0000759_abnormal_skeletal_muscle3.68386089
10MP0004087_abnormal_muscle_fiber3.50544802
11MP0002269_muscular_atrophy3.46949146
12MP0005369_muscle_phenotype3.43061634
13MP0004130_abnormal_muscle_cell3.33527672
14MP0000750_abnormal_muscle_regeneration3.26516030
15MP0005620_abnormal_muscle_contractility3.12540947
16MP0004233_abnormal_muscle_weight2.58203457
17MP0005330_cardiomyopathy2.33176406
18MP0004084_abnormal_cardiac_muscle2.27621006
19MP0000733_abnormal_muscle_development2.25538975
20MP0002332_abnormal_exercise_endurance2.15916063
21MP0002108_abnormal_muscle_morphology1.97055839
22MP0006036_abnormal_mitochondrial_physio1.96705806
23MP0004215_abnormal_myocardial_fiber1.92009957
24MP0004185_abnormal_adipocyte_glucose1.67542645
25MP0004484_altered_response_of1.63248185
26MP0002972_abnormal_cardiac_muscle1.62724126
27MP0005666_abnormal_adipose_tissue1.52142984
28MP0010630_abnormal_cardiac_muscle1.44038463
29MP0003221_abnormal_cardiomyocyte_apopto1.37171678
30MP0002971_abnormal_brown_adipose1.35112902
31MP0004270_analgesia1.21461916
32MP0001544_abnormal_cardiovascular_syste1.18729224
33MP0005385_cardiovascular_system_phenoty1.18729224
34MP0000013_abnormal_adipose_tissue1.18327823
35MP0005375_adipose_tissue_phenotype1.17283920
36MP0003950_abnormal_plasma_membrane1.14963270
37MP0002822_catalepsy1.10765724
38MP0001661_extended_life_span1.09538337
39MP0003806_abnormal_nucleotide_metabolis1.08598070
40MP0003137_abnormal_impulse_conducting1.07182309
41MP0005266_abnormal_metabolism1.04935433
42MP0006035_abnormal_mitochondrial_morpho0.98620243
43MP0002234_abnormal_pharynx_morphology0.90741291
44MP0008775_abnormal_heart_ventricle0.88537056
45MP0003705_abnormal_hypodermis_morpholog0.87822674
46MP0005275_abnormal_skin_tensile0.86710914
47MP0009780_abnormal_chondrocyte_physiolo0.77046592
48MP0000003_abnormal_adipose_tissue0.72943088
49MP0002127_abnormal_cardiovascular_syste0.72801796
50MP0004134_abnormal_chest_morphology0.70909395
51MP0006138_congestive_heart_failure0.70364099
52MP0005670_abnormal_white_adipose0.69703417
53MP0004043_abnormal_pH_regulation0.68007596
54MP0000343_altered_response_to0.67177856
55MP0004147_increased_porphyrin_level0.65588236
56MP0008961_abnormal_basal_metabolism0.64160263
57MP0000762_abnormal_tongue_morphology0.63349818
58MP0001299_abnormal_eye_distance/0.63264199
59MP0003879_abnormal_hair_cell0.61911906
60MP0000266_abnormal_heart_morphology0.61734238
61MP0005334_abnormal_fat_pad0.61115037
62MP0000372_irregular_coat_pigmentation0.60504187
63MP0003656_abnormal_erythrocyte_physiolo0.60462133
64MP0002078_abnormal_glucose_homeostasis0.60421042
65MP0009250_abnormal_appendicular_skeleto0.59386050
66MP0003828_pulmonary_edema0.55344181
67MP0004510_myositis0.52587496
68MP0004085_abnormal_heartbeat0.50263953
69MP0003045_fibrosis0.49040734
70MP0010030_abnormal_orbit_morphology0.48680727
71MP0005452_abnormal_adipose_tissue0.43059991
72MP0005584_abnormal_enzyme/coenzyme_acti0.41960039
73MP0005167_abnormal_blood-brain_barrier0.41536050
74MP0008569_lethality_at_weaning0.39768169
75MP0002896_abnormal_bone_mineralization0.38887769
76MP0003567_abnormal_fetal_cardiomyocyte0.38772276
77MP0002638_abnormal_pupillary_reflex0.38744523
78MP0000579_abnormal_nail_morphology0.38016555
79MP0005319_abnormal_enzyme/_coenzyme0.37511977
80MP0000230_abnormal_systemic_arterial0.35821787
81MP0005083_abnormal_biliary_tract0.35014062
82MP0003959_abnormal_lean_body0.34956821
83MP0001346_abnormal_lacrimal_gland0.34081909
84MP0002796_impaired_skin_barrier0.33129820
85MP0009672_abnormal_birth_weight0.32039355
86MP0002734_abnormal_mechanical_nocicepti0.31810758
87MP0009115_abnormal_fat_cell0.31490519
88MP0005451_abnormal_body_composition0.30580219
89MP0003948_abnormal_gas_homeostasis0.30349194
90MP0002089_abnormal_postnatal_growth/wei0.29970909
91MP0005535_abnormal_body_temperature0.28066697
92MP0002128_abnormal_blood_circulation0.28010909
93MP0001849_ear_inflammation0.27657571
94MP0005332_abnormal_amino_acid0.27063194
95MP0002114_abnormal_axial_skeleton0.26589259
96MP0005423_abnormal_somatic_nervous0.25992169
97MP0004142_abnormal_muscle_tone0.24778230
98MP0002118_abnormal_lipid_homeostasis0.24287439
99MP0001853_heart_inflammation0.24128646
100MP0005165_increased_susceptibility_to0.23813739
101MP0005376_homeostasis/metabolism_phenot0.22713990
102MP0003195_calcinosis0.21862737
103MP0002066_abnormal_motor_capabilities/c0.21742229
104MP0001243_abnormal_dermal_layer0.20616941
105MP0005503_abnormal_tendon_morphology0.20251848
106MP0005187_abnormal_penis_morphology0.20151766
107MP0005166_decreased_susceptibility_to0.20032295
108MP0008438_abnormal_cutaneous_collagen0.19702231
109MP0000383_abnormal_hair_follicle0.18114899
110MP0005645_abnormal_hypothalamus_physiol0.17469868
111MP0008770_decreased_survivor_rate0.17254490
112MP0001943_abnormal_respiration0.17117981
113MP0002067_abnormal_sensory_capabilities0.15219608
114MP0002249_abnormal_larynx_morphology0.15193988
115MP0006276_abnormal_autonomic_nervous0.15152604
116MP0002970_abnormal_white_adipose0.15057208
117MP0002876_abnormal_thyroid_physiology0.14819146
118MP0009697_abnormal_copulation0.13333554
119MP0004858_abnormal_nervous_system0.13159375
120MP0004924_abnormal_behavior0.13044679

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.77089229
2* Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.26349966
3Exercise-induced myalgia (HP:0003738)8.76954847
4Type 1 muscle fiber predominance (HP:0003803)8.08917699
5Exercise-induced muscle cramps (HP:0003710)7.87050437
6Distal arthrogryposis (HP:0005684)7.49949500
7Muscle hypertrophy of the lower extremities (HP:0008968)7.04740508
8Myopathic facies (HP:0002058)6.79116472
9Calf muscle hypertrophy (HP:0008981)6.43855085
10Round ear (HP:0100830)6.03936023
11Ulnar deviation of the wrist (HP:0003049)5.85608407
12Difficulty running (HP:0009046)5.47624357
13Myoglobinuria (HP:0002913)5.33364595
14Calcaneovalgus deformity (HP:0001848)5.09064634
15Absent phalangeal crease (HP:0006109)4.72685992
16Deformed tarsal bones (HP:0008119)4.66534463
17Increased connective tissue (HP:0009025)4.55644884
18Abnormality of the calf musculature (HP:0001430)4.48574311
19Rhabdomyolysis (HP:0003201)4.43216082
20* EMG: myopathic abnormalities (HP:0003458)4.24969472
21Myotonia (HP:0002486)4.18934266
22Abnormality of skeletal muscle fiber size (HP:0012084)4.08245874
23Abnormal finger flexion creases (HP:0006143)3.94943486
24* Hyporeflexia of lower limbs (HP:0002600)3.93327587
25* Muscle stiffness (HP:0003552)3.88049557
26Subaortic stenosis (HP:0001682)3.82479974
27Abnormality of the left ventricular outflow tract (HP:0011103)3.82479974
28* Muscle fiber splitting (HP:0003555)3.75369401
29Increased variability in muscle fiber diameter (HP:0003557)3.64437022
30Frequent falls (HP:0002359)3.45155242
31Difficulty climbing stairs (HP:0003551)3.44008763
32Malignant hyperthermia (HP:0002047)3.33399394
33Sudden death (HP:0001699)3.24689809
34* Neck muscle weakness (HP:0000467)3.20114521
35Asymmetric septal hypertrophy (HP:0001670)3.17391434
36Abnormality of the calcaneus (HP:0008364)3.02964461
37Hyperkalemia (HP:0002153)2.94765620
38Slender build (HP:0001533)2.76750890
39Distal lower limb muscle weakness (HP:0009053)2.75997526
40EMG: neuropathic changes (HP:0003445)2.67188704
41Fatigable weakness (HP:0003473)2.57568231
42Abnormality of the neuromuscular junction (HP:0003398)2.57568231
43Mildly elevated creatine phosphokinase (HP:0008180)2.52926246
44Paralysis (HP:0003470)2.44878221
45Generalized muscle weakness (HP:0003324)2.41843014
46Proximal amyotrophy (HP:0007126)2.41361338
47Facial diplegia (HP:0001349)2.41130691
48Ventricular tachycardia (HP:0004756)2.40145061
49Progressive muscle weakness (HP:0003323)2.38048722
50Bulbar palsy (HP:0001283)2.35438365
51Spinal rigidity (HP:0003306)2.33996773
52Hypoplastic ischia (HP:0003175)2.30759741
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.27770816
54* Areflexia of lower limbs (HP:0002522)2.27225444
55Scapular winging (HP:0003691)2.24538351
56Gowers sign (HP:0003391)2.23770324
57Distal lower limb amyotrophy (HP:0008944)2.23740600
58* Rimmed vacuoles (HP:0003805)2.23508086
59Popliteal pterygium (HP:0009756)2.21054708
60Limb-girdle muscle atrophy (HP:0003797)2.17639852
61Weak cry (HP:0001612)2.10251835
62Nonprogressive disorder (HP:0003680)2.08169804
63Ulnar deviation of finger (HP:0009465)2.03614402
64Type 2 muscle fiber atrophy (HP:0003554)2.01647593
65Abnormality of the ischium (HP:0003174)2.01470768
66Metatarsus adductus (HP:0001840)2.00564111
67* Muscle fiber inclusion bodies (HP:0100299)10.0224190
68Lipoatrophy (HP:0100578)1.97095711
69Hip contracture (HP:0003273)1.96279692
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95781085
71* Muscular dystrophy (HP:0003560)1.92552399
72Heart block (HP:0012722)1.89807046
73Dilated cardiomyopathy (HP:0001644)1.89362926
74Long clavicles (HP:0000890)1.86395522
75Muscle fiber atrophy (HP:0100295)1.84583129
76Fetal akinesia sequence (HP:0001989)1.82863251
77Abnormal atrioventricular conduction (HP:0005150)1.78204688
78Ragged-red muscle fibers (HP:0003200)1.73949452
79Lower limb amyotrophy (HP:0007210)1.66060384
80Bundle branch block (HP:0011710)1.65698965
81* Abnormality of the shoulder girdle musculature (HP:0001435)1.64667200
82Respiratory insufficiency due to muscle weakness (HP:0002747)1.63985485
83Cholelithiasis (HP:0001081)1.63644333
84Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.61910602
85Amniotic constriction ring (HP:0009775)1.60684532
86Abnormality of placental membranes (HP:0011409)1.60684532
87Foot dorsiflexor weakness (HP:0009027)1.58670804
88Exercise intolerance (HP:0003546)1.57734528
89Tarsal synostosis (HP:0008368)1.57173112
90Ventricular arrhythmia (HP:0004308)1.56976088
91Increased intramyocellular lipid droplets (HP:0012240)1.56269608
92Right ventricular cardiomyopathy (HP:0011663)1.54268483
93Increased purine levels (HP:0004368)1.54250235
94Hyperuricemia (HP:0002149)1.54250235
95Steppage gait (HP:0003376)1.53569796
96Abnormality of the foot musculature (HP:0001436)1.52832947
97Limited hip movement (HP:0008800)1.49772266
98Abnormality of potassium homeostasis (HP:0011042)1.49326010
99* Waddling gait (HP:0002515)1.48506323
100Short palpebral fissure (HP:0012745)1.47871669
101Increased muscle lipid content (HP:0009058)1.47268600
102* Limb-girdle muscle weakness (HP:0003325)1.46779807
103Stridor (HP:0010307)1.45720111
104Congenital hip dislocation (HP:0001374)1.45277215
105Adducted thumb (HP:0001181)1.45272715
106Palpitations (HP:0001962)1.44750982
107Easy fatigability (HP:0003388)1.43754104
108Abnormal gallbladder morphology (HP:0012437)1.43520771
109* Abnormality of the hip-girdle musculature (HP:0001445)1.43511074
110* Abnormality of the musculature of the pelvis (HP:0001469)1.43511074
111Gout (HP:0001997)1.42430645
112Synostosis involving bones of the lower limbs (HP:0009138)1.41443647
113Synostosis involving bones of the feet (HP:0009140)1.41443647
114Toxemia of pregnancy (HP:0100603)1.38568416
115Oligomenorrhea (HP:0000876)1.37843180
116Insulin-resistant diabetes mellitus (HP:0000831)1.30322886
117Diaphragmatic weakness (HP:0009113)1.25746883
118Neonatal hypotonia (HP:0001319)1.17237073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.55832495
2TTN6.37194404
3PHKG15.08419551
4PHKG25.08419551
5NME13.86691499
6PIK3CG3.71550584
7MAP2K32.65316993
8NEK12.27168302
9PINK12.14797981
10PDK32.13665861
11PDK42.13665861
12DMPK2.01161631
13MAP3K72.00847476
14TRIB31.84934421
15MUSK1.63493559
16BCKDK1.61345950
17MAPK121.55218639
18PIK3CA1.50457317
19MAP2K41.41809625
20PDK21.38667153
21MAP2K61.24083963
22CCNB11.07523090
23MAP3K30.98286980
24MARK10.95743749
25PKN20.91627558
26MAP3K130.88382917
27MAPKAPK30.84528385
28PRKAA20.83801505
29NEK90.81882122
30PRKAA10.80265080
31AKT20.68271990
32ZAK0.65281259
33ERBB30.63927132
34TRPM70.63906675
35STK240.62809468
36TAOK20.62386433
37MAPK110.57740237
38CAMK40.57464675
39CAMK2G0.54794241
40MAP3K110.54022376
41TAOK10.52057591
42RIPK10.50824584
43EPHB10.50768181
44TIE10.44768146
45ILK0.44375510
46SIK10.43976402
47CAMK10.40951999
48CAMK2B0.40913584
49PTK60.40497302
50ARAF0.39337120
51LIMK10.36470294
52MAP3K60.36380413
53PKN10.36059664
54SGK20.34910952
55MAP3K50.32313018
56RPS6KB10.31567179
57SGK10.30316960
58ROCK10.29487021
59MARK30.29262588
60TBK10.28624165
61PRKACB0.28457283
62MAPK130.28046496
63PRKD10.27629569
64INSRR0.27056836
65PRKG10.25750955
66EEF2K0.25247870
67TGFBR20.25115313
68MAP3K10.23082856
69RPS6KA30.21907829
70CAMK2D0.21611166
71RPS6KB20.20460545
72PRKACA0.20152670
73DAPK20.20029388
74MAP3K90.19879210
75MAPK40.19336984
76KSR20.17860833
77PDPK10.17764563
78SGK4940.16714273
79SGK2230.16714273
80MAPK70.16609833
81CDK190.15063506
82MARK20.14666269
83RAF10.14328674
84PDK10.14075599
85LATS10.13492899
86MAP2K10.12666132
87LATS20.11439090
88PRKG20.10468952
89ICK0.10384425
90PRPF4B0.10316881
91BRAF0.09668262
92MOS0.09372587
93MAP3K100.09034897
94PAK60.08728083
95RPS6KC10.08658338
96RPS6KL10.08658338
97TYK20.08576102
98FLT30.08273973
99RPS6KA10.08177086
100PRKACG0.07907529
101ZAP700.07515192
102DYRK1B0.06911873
103ERN10.06884642
104GSK3A0.06506535
105KSR10.06361100
106NLK0.06058287
107CAMK1G0.05726352
108RPS6KA60.05429316
109BMX0.05242984
110LMTK20.05148700
111STK110.04919963
112ROCK20.04849278
113SGK30.04377141
114MTOR0.04208795
115CAMK2A0.04183853
116JAK20.04060091
117LRRK20.04034284
118FER0.03462621
119PDGFRA0.03228510
120PTK2B0.02741065
121FGFR10.02545841
122GSK3B0.01942463
123MAPK80.01410384
124CSNK1D0.01159334
125MAPK100.01125281
126MAP3K4-0.0352018
127MAPK9-0.0301226
128FGFR3-0.0238026
129STK38-0.0105975
130RET-0.0017315

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.77923972
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.14922608
3Cardiac muscle contraction_Homo sapiens_hsa042603.86515073
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.63590072
5Dilated cardiomyopathy_Homo sapiens_hsa054143.51610875
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.47376126
7Starch and sucrose metabolism_Homo sapiens_hsa005002.73553527
8Propanoate metabolism_Homo sapiens_hsa006402.72499562
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53822455
10Carbon metabolism_Homo sapiens_hsa012002.28009373
11Glucagon signaling pathway_Homo sapiens_hsa049222.15483853
12Parkinsons disease_Homo sapiens_hsa050122.12076638
13Insulin signaling pathway_Homo sapiens_hsa049102.09948507
14Insulin resistance_Homo sapiens_hsa049311.94250309
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.93165359
16Circadian rhythm_Homo sapiens_hsa047101.92112967
17Oxytocin signaling pathway_Homo sapiens_hsa049211.92054319
18Oxidative phosphorylation_Homo sapiens_hsa001901.86875794
19Alzheimers disease_Homo sapiens_hsa050101.84890414
20Fatty acid degradation_Homo sapiens_hsa000711.79879178
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77308162
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72932907
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64216299
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.61824310
25Pyruvate metabolism_Homo sapiens_hsa006201.55755031
26Viral myocarditis_Homo sapiens_hsa054161.54939290
27AMPK signaling pathway_Homo sapiens_hsa041521.53683075
28Calcium signaling pathway_Homo sapiens_hsa040201.53333191
29Galactose metabolism_Homo sapiens_hsa000521.49665442
30Biosynthesis of amino acids_Homo sapiens_hsa012301.37517332
31Fatty acid metabolism_Homo sapiens_hsa012121.27634067
32Fructose and mannose metabolism_Homo sapiens_hsa000511.26312441
33Tight junction_Homo sapiens_hsa045301.25179450
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19841384
35Arginine and proline metabolism_Homo sapiens_hsa003301.19276408
36Nitrogen metabolism_Homo sapiens_hsa009101.18693090
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14531170
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12180722
39Huntingtons disease_Homo sapiens_hsa050161.01025602
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.99513373
41Focal adhesion_Homo sapiens_hsa045100.92266480
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89374226
43Gastric acid secretion_Homo sapiens_hsa049710.86385424
44Arginine biosynthesis_Homo sapiens_hsa002200.83150018
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81562832
46GnRH signaling pathway_Homo sapiens_hsa049120.81520099
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.79705303
48FoxO signaling pathway_Homo sapiens_hsa040680.77119569
49Pentose phosphate pathway_Homo sapiens_hsa000300.76373011
50Long-term potentiation_Homo sapiens_hsa047200.76263773
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74034364
52HIF-1 signaling pathway_Homo sapiens_hsa040660.71186568
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67536606
54PPAR signaling pathway_Homo sapiens_hsa033200.66514619
55Fatty acid biosynthesis_Homo sapiens_hsa000610.63863141
56Butanoate metabolism_Homo sapiens_hsa006500.63461142
57mTOR signaling pathway_Homo sapiens_hsa041500.61372319
58Renin secretion_Homo sapiens_hsa049240.61064853
59VEGF signaling pathway_Homo sapiens_hsa043700.59656988
60beta-Alanine metabolism_Homo sapiens_hsa004100.57275741
61MAPK signaling pathway_Homo sapiens_hsa040100.54353076
62Type II diabetes mellitus_Homo sapiens_hsa049300.50675164
63Insulin secretion_Homo sapiens_hsa049110.48994171
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45081375
65Platelet activation_Homo sapiens_hsa046110.44575591
66Fatty acid elongation_Homo sapiens_hsa000620.38701056
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.38651740
68Amoebiasis_Homo sapiens_hsa051460.36914035
69Regulation of autophagy_Homo sapiens_hsa041400.36651478
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36301653
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35166313
72Adherens junction_Homo sapiens_hsa045200.33808648
73Phenylalanine metabolism_Homo sapiens_hsa003600.33012324
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30994059
75Proteoglycans in cancer_Homo sapiens_hsa052050.30196465
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28451125
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28403924
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26641979
79Renal cell carcinoma_Homo sapiens_hsa052110.25947645
80Purine metabolism_Homo sapiens_hsa002300.24619459
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22373485
82Histidine metabolism_Homo sapiens_hsa003400.21468371
83Peroxisome_Homo sapiens_hsa041460.21370977
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20142861
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19645765
86Glioma_Homo sapiens_hsa052140.19536064
87Amphetamine addiction_Homo sapiens_hsa050310.19203863
88Tryptophan metabolism_Homo sapiens_hsa003800.18907158
89Olfactory transduction_Homo sapiens_hsa047400.17764451
90Fat digestion and absorption_Homo sapiens_hsa049750.17215228
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16980410
92Thyroid cancer_Homo sapiens_hsa052160.15956344
93Cholinergic synapse_Homo sapiens_hsa047250.15209990
94Linoleic acid metabolism_Homo sapiens_hsa005910.14546692
95Pancreatic secretion_Homo sapiens_hsa049720.14218848
96Long-term depression_Homo sapiens_hsa047300.13782649
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12731763
98Metabolic pathways_Homo sapiens_hsa011000.12456952
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12156870
100ABC transporters_Homo sapiens_hsa020100.11448647
101Circadian entrainment_Homo sapiens_hsa047130.10962057
102Melanogenesis_Homo sapiens_hsa049160.10908335
103Bile secretion_Homo sapiens_hsa049760.10378632
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.09591821
105Lysine degradation_Homo sapiens_hsa003100.09423525
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08983163
107Oocyte meiosis_Homo sapiens_hsa041140.08681351
108Prolactin signaling pathway_Homo sapiens_hsa049170.08276563
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07938622
110Salivary secretion_Homo sapiens_hsa049700.07462430
111cAMP signaling pathway_Homo sapiens_hsa040240.06239040
112ECM-receptor interaction_Homo sapiens_hsa045120.05903214
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05250241
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.05110168
115Tyrosine metabolism_Homo sapiens_hsa003500.05000102
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.03706179

Most similar genes based on co-expression Upload to Enrichr

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