MYOZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle fiber development (GO:0048741)8.27081109
2actin filament-based movement (GO:0030048)8.05874723
3plasma membrane repair (GO:0001778)7.12054389
4myotube cell development (GO:0014904)7.08029129
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.07043951
6glycogen catabolic process (GO:0005980)6.94841662
7striated muscle contraction (GO:0006941)6.81571186
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.59423064
9sarcomere organization (GO:0045214)6.57742962
10skeletal muscle tissue regeneration (GO:0043403)6.56323434
11glucan catabolic process (GO:0009251)6.50914551
12creatine metabolic process (GO:0006600)6.48641974
13purine nucleotide salvage (GO:0032261)6.15699650
14cellular polysaccharide catabolic process (GO:0044247)6.07787691
15striated muscle atrophy (GO:0014891)6.02935263
16pyrimidine ribonucleoside catabolic process (GO:0046133)6.00808709
17carnitine shuttle (GO:0006853)6.00760858
18response to muscle activity (GO:0014850)5.83534040
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.81774886
20polysaccharide catabolic process (GO:0000272)5.81766547
21cytidine catabolic process (GO:0006216)5.74265758
22cytidine deamination (GO:0009972)5.74265758
23cytidine metabolic process (GO:0046087)5.74265758
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.70993321
25regulation of cell communication by electrical coupling (GO:0010649)5.68131119
26muscle contraction (GO:0006936)5.64079841
27response to inactivity (GO:0014854)5.61142279
28striated muscle adaptation (GO:0014888)5.31984172
29IMP metabolic process (GO:0046040)5.26664782
30glycogen biosynthetic process (GO:0005978)5.25014993
31glucan biosynthetic process (GO:0009250)5.25014993
32muscle atrophy (GO:0014889)5.24650259
33fatty acid transmembrane transport (GO:1902001)5.05387094
34muscle system process (GO:0003012)5.01747260
35muscle fiber development (GO:0048747)5.00345795
36NADH metabolic process (GO:0006734)4.98238512
37positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.79707285
38regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.76459846
39cardiac muscle hypertrophy (GO:0003300)4.62044828
40glycogen metabolic process (GO:0005977)4.61062658
41glucan metabolic process (GO:0044042)4.51902268
42cellular glucan metabolic process (GO:0006073)4.51902268
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.49996201
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.44609869
45carnitine transmembrane transport (GO:1902603)4.44496088
46striated muscle hypertrophy (GO:0014897)4.41053531
47fructose metabolic process (GO:0006000)4.33978141
48regulation of acyl-CoA biosynthetic process (GO:0050812)4.33852389
49* myofibril assembly (GO:0030239)4.33830836
50muscle adaptation (GO:0043500)4.31820037
51neuronal action potential propagation (GO:0019227)4.20605108
52negative regulation of muscle hypertrophy (GO:0014741)4.18556173
53muscle cell fate commitment (GO:0042693)4.18555546
54negative regulation of skeletal muscle tissue development (GO:0048642)4.14197675
55muscle organ morphogenesis (GO:0048644)4.12849181
562-oxoglutarate metabolic process (GO:0006103)4.10921929
57IMP biosynthetic process (GO:0006188)4.08114343
58amino-acid betaine transport (GO:0015838)4.05783009
59carnitine transport (GO:0015879)4.05783009
60response to activity (GO:0014823)4.04224522
61regulation of skeletal muscle cell differentiation (GO:2001014)4.04190108
62* actomyosin structure organization (GO:0031032)4.03675714
63regulation of relaxation of muscle (GO:1901077)4.02268677
64gluconeogenesis (GO:0006094)3.98182709
65muscle hypertrophy (GO:0014896)3.95270282
66cardiac muscle contraction (GO:0060048)3.92965405
67regulation of cofactor metabolic process (GO:0051193)3.92836314
68regulation of coenzyme metabolic process (GO:0051196)3.92836314
69cellular carbohydrate catabolic process (GO:0044275)3.89407787
70muscle tissue morphogenesis (GO:0060415)3.88602784
71muscle organ development (GO:0007517)3.85736235
72cellular response to dexamethasone stimulus (GO:0071549)3.84245821
73muscle cell cellular homeostasis (GO:0046716)3.83129776
74muscle structure development (GO:0061061)3.80759910
75regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.77519076
76neuromuscular synaptic transmission (GO:0007274)3.75527719
77striated muscle cell development (GO:0055002)3.72346006
78adult heart development (GO:0007512)3.71247324
79cardiac muscle tissue morphogenesis (GO:0055008)3.65122287
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.60318538
81negative regulation of calcium ion transmembrane transport (GO:1903170)3.60318538
82myotube differentiation (GO:0014902)3.60204751
83response to dexamethasone (GO:0071548)3.58398037
84hexose biosynthetic process (GO:0019319)3.55971715
85regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.55439526
86skeletal muscle tissue development (GO:0007519)3.54134533
87tricarboxylic acid cycle (GO:0006099)3.50367921
88negative regulation of muscle contraction (GO:0045932)3.49685933
89cardiac muscle cell development (GO:0055013)3.48016925
90regulation of calcium ion transmembrane transporter activity (GO:1901019)3.44136811
91regulation of calcium ion transmembrane transport (GO:1903169)3.44136811
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.42333340
93cardiac muscle hypertrophy in response to stress (GO:0014898)3.41482213
94muscle hypertrophy in response to stress (GO:0003299)3.41482213
95cardiac muscle adaptation (GO:0014887)3.41482213
96negative regulation of potassium ion transmembrane transport (GO:1901380)3.39706996
97striated muscle tissue development (GO:0014706)3.39046463
98heart process (GO:0003015)3.35110054
99heart contraction (GO:0060047)3.35110054
100regulation of striated muscle contraction (GO:0006942)3.31417240
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31390555
102ubiquinone biosynthetic process (GO:0006744)3.30281866
103positive regulation of myotube differentiation (GO:0010831)3.29740256
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27296263
105syncytium formation by plasma membrane fusion (GO:0000768)3.26957192
106myoblast fusion (GO:0007520)3.26148386
107cellular polysaccharide metabolic process (GO:0044264)3.24637935
108cardiac cell development (GO:0055006)3.22305094
109relaxation of muscle (GO:0090075)3.22007501
110positive regulation of cation channel activity (GO:2001259)3.20587271
111regulation of sulfur metabolic process (GO:0042762)3.19234400
112regulation of actin filament-based movement (GO:1903115)3.17293497
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.17272166
114muscle cell development (GO:0055001)3.16947658
115cardiac myofibril assembly (GO:0055003)3.13913590
116positive regulation of myoblast differentiation (GO:0045663)3.13648164
117negative regulation of cAMP-mediated signaling (GO:0043951)3.12313004
118cellular polysaccharide biosynthetic process (GO:0033692)3.11540169
119neuromuscular junction development (GO:0007528)3.08221083
120polysaccharide biosynthetic process (GO:0000271)3.06532008
121regulation of myoblast differentiation (GO:0045661)3.00752854
122muscle filament sliding (GO:0030049)13.1763294
123actin-myosin filament sliding (GO:0033275)13.1763294
124regulation of skeletal muscle contraction (GO:0014819)12.8222461
125skeletal muscle contraction (GO:0003009)11.5011532
126actin-mediated cell contraction (GO:0070252)10.7875679
127sarcoplasmic reticulum calcium ion transport (GO:0070296)10.5741948
128skeletal muscle adaptation (GO:0043501)10.2435953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.50994243
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45413764
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.49241076
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42390473
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.28199103
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.25918217
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.80577773
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46203496
9TBX20_22080862_ChIP-Seq_HEART_Mouse2.44702183
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.44702183
11ZNF263_19887448_ChIP-Seq_K562_Human2.44149178
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.38094087
13* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.35576344
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20978214
15AR_21572438_ChIP-Seq_LNCaP_Human2.19598974
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04936247
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.84232252
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83495346
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.81948292
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.75056875
21* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.71622819
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71301181
23CTCF_27219007_Chip-Seq_Bcells_Human1.70892847
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68769826
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63279627
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62476043
27CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.57682287
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.54783756
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48772882
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47676542
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.47627153
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42781167
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.41282871
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40089586
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38812468
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37142302
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.35896379
38SA1_27219007_Chip-Seq_Bcells_Human1.34094703
39STAT1_20625510_ChIP-Seq_HELA_Human1.32924752
40CLOCK_20551151_ChIP-Seq_293T_Human1.30877401
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26765093
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26740288
43EZH2_22144423_ChIP-Seq_EOC_Human1.26633295
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.24966492
45* FOXH1_21741376_ChIP-Seq_ESCs_Human1.24409540
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21791762
47SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20568753
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19588450
49IGF1R_20145208_ChIP-Seq_DFB_Human1.18565770
50DROSHA_22980978_ChIP-Seq_HELA_Human1.15486224
51STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14387140
52CBP_20019798_ChIP-Seq_JUKART_Human1.13265367
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13265367
54GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12882553
55* OCT4_20526341_ChIP-Seq_ESCs_Human1.10460496
56* KDM2B_26808549_Chip-Seq_DND41_Human1.10246099
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07415196
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07104429
59* CTCF_21964334_Chip-Seq_Bcells_Human1.06764533
60* RARB_27405468_Chip-Seq_BRAIN_Mouse1.06683296
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06272603
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05967321
63CREB1_26743006_Chip-Seq_LNCaP_Human1.05947625
64SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05811570
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.05654829
66* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04327999
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03574585
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03289107
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.02692586
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02469124
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02448936
72MYC_27129775_Chip-Seq_CORNEA_Mouse1.02411603
73RACK7_27058665_Chip-Seq_MCF-7_Human1.02314341
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01094132
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99726803
76ELF1_20517297_ChIP-Seq_JURKAT_Human0.99686225
77EZH2_27294783_Chip-Seq_ESCs_Mouse0.98435577
78TP53_20018659_ChIP-ChIP_R1E_Mouse0.98282408
79P68_20966046_ChIP-Seq_HELA_Human0.98139258
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.97604748
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97193213
82E2F1_20622854_ChIP-Seq_HELA_Human0.96826422
83LXR_22292898_ChIP-Seq_THP-1_Human0.96029169
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95549612
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.95240033
86OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94603233
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94314642
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.94124749
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93975217
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93398624
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91941221
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91889071
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.91855858
94* NANOG_20526341_ChIP-Seq_ESCs_Human0.90913462
95* SPI1_20517297_ChIP-Seq_HL60_Human0.90587141
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89615858
97* RAC3_21632823_ChIP-Seq_H3396_Human0.89151395
98BCL6_27268052_Chip-Seq_Bcells_Human0.88940494
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88720163
100TP63_22573176_ChIP-Seq_HFKS_Human0.88491089
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88394535
102* CTCF_26484167_Chip-Seq_Bcells_Mouse0.88141844
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.87880773
104CJUN_26792858_Chip-Seq_BT549_Human0.87361933
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86307858
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86278818
107ATF3_27146783_Chip-Seq_COLON_Human0.86036291
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85807804
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85666029
110P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85381891
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85365779
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85179593
113OCT1_27270436_Chip-Seq_PROSTATE_Human0.84958954
114* CEBPB_22108803_ChIP-Seq_LS180_Human0.84717383
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84704478
116CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84556518
117* TCF7_22412390_ChIP-Seq_EML_Mouse0.83292277
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83171889
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.83089027
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82709473
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82360953
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82283537
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82044422
124LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.81938030
125FLI1_27457419_Chip-Seq_LIVER_Mouse0.81039691
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80436488
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80326457
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80069059
129NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80069059
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79663716
131EGR1_19032775_ChIP-ChIP_M12_Human0.79037918
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.75904940
133HTT_18923047_ChIP-ChIP_STHdh_Human0.75792997
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.73596812
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72750180
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.71070529
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.70287288
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69786489
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.69038227
140* DPY_21335234_ChIP-Seq_ESCs_Mouse0.68917385
141GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68337629
142GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67955722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.50267799
2MP0003646_muscle_fatigue6.55601727
3MP0000751_myopathy5.80471594
4* MP0000749_muscle_degeneration5.78493872
5MP0000747_muscle_weakness4.70696613
6MP0004036_abnormal_muscle_relaxation4.22579648
7* MP0002106_abnormal_muscle_physiology4.21697056
8* MP0000759_abnormal_skeletal_muscle3.85724386
9MP0002269_muscular_atrophy3.71570608
10* MP0005369_muscle_phenotype3.51990109
11MP0002837_dystrophic_cardiac_calcinosis3.46462016
12MP0004130_abnormal_muscle_cell3.46243964
13* MP0004087_abnormal_muscle_fiber3.37742719
14MP0005620_abnormal_muscle_contractility3.29151327
15MP0004233_abnormal_muscle_weight2.75261378
16MP0000733_abnormal_muscle_development2.44710090
17* MP0000750_abnormal_muscle_regeneration2.26495436
18MP0002108_abnormal_muscle_morphology2.12776832
19MP0006036_abnormal_mitochondrial_physio1.98327484
20MP0005330_cardiomyopathy1.90790228
21MP0004185_abnormal_adipocyte_glucose1.80586673
22MP0004084_abnormal_cardiac_muscle1.65514345
23MP0002971_abnormal_brown_adipose1.42712711
24MP0005666_abnormal_adipose_tissue1.41974627
25MP0004270_analgesia1.38881540
26MP0002972_abnormal_cardiac_muscle1.30923792
27MP0004484_altered_response_of1.27295670
28MP0004215_abnormal_myocardial_fiber1.26979381
29MP0003806_abnormal_nucleotide_metabolis1.26815860
30MP0003221_abnormal_cardiomyocyte_apopto1.21754696
31MP0010630_abnormal_cardiac_muscle1.20355569
32* MP0002332_abnormal_exercise_endurance1.11613400
33MP0005275_abnormal_skin_tensile1.09841078
34MP0001661_extended_life_span1.09496833
35MP0005375_adipose_tissue_phenotype1.05998654
36MP0003950_abnormal_plasma_membrane1.05007750
37MP0000013_abnormal_adipose_tissue1.03597567
38MP0006035_abnormal_mitochondrial_morpho1.03325496
39MP0002822_catalepsy1.03054097
40MP0003705_abnormal_hypodermis_morpholog1.01062811
41MP0004134_abnormal_chest_morphology0.96273080
42MP0005385_cardiovascular_system_phenoty0.87395942
43MP0001544_abnormal_cardiovascular_syste0.87395942
44MP0000372_irregular_coat_pigmentation0.82908060
45MP0003656_abnormal_erythrocyte_physiolo0.82119489
46MP0009780_abnormal_chondrocyte_physiolo0.78423366
47MP0004147_increased_porphyrin_level0.77366020
48MP0009250_abnormal_appendicular_skeleto0.76598071
49MP0002234_abnormal_pharynx_morphology0.72755323
50MP0000762_abnormal_tongue_morphology0.71882959
51MP0001299_abnormal_eye_distance/0.71230168
52MP0003137_abnormal_impulse_conducting0.70546292
53MP0008961_abnormal_basal_metabolism0.68625608
54MP0004043_abnormal_pH_regulation0.67413844
55MP0005334_abnormal_fat_pad0.65832291
56* MP0005266_abnormal_metabolism0.64505806
57MP0003879_abnormal_hair_cell0.63462407
58MP0002078_abnormal_glucose_homeostasis0.62500962
59MP0000003_abnormal_adipose_tissue0.57499001
60MP0000343_altered_response_to0.55634765
61MP0005670_abnormal_white_adipose0.55340390
62MP0002127_abnormal_cardiovascular_syste0.54852890
63MP0008775_abnormal_heart_ventricle0.54337041
64MP0000266_abnormal_heart_morphology0.53914215
65MP0002089_abnormal_postnatal_growth/wei0.52834403
66MP0010030_abnormal_orbit_morphology0.51653653
67MP0005083_abnormal_biliary_tract0.49194015
68MP0005584_abnormal_enzyme/coenzyme_acti0.48598247
69MP0005452_abnormal_adipose_tissue0.48471022
70MP0002896_abnormal_bone_mineralization0.47558174
71MP0003959_abnormal_lean_body0.46774489
72MP0008569_lethality_at_weaning0.45262703
73MP0003045_fibrosis0.44102205
74MP0001346_abnormal_lacrimal_gland0.43768602
75MP0005167_abnormal_blood-brain_barrier0.43601354
76MP0009672_abnormal_birth_weight0.43511772
77MP0002796_impaired_skin_barrier0.43238320
78MP0000579_abnormal_nail_morphology0.41616829
79MP0002638_abnormal_pupillary_reflex0.40018876
80MP0001243_abnormal_dermal_layer0.37340748
81MP0002114_abnormal_axial_skeleton0.37092254
82MP0004510_myositis0.35443097
83MP0000383_abnormal_hair_follicle0.35433033
84MP0001849_ear_inflammation0.35421576
85MP0006138_congestive_heart_failure0.35226287
86MP0002734_abnormal_mechanical_nocicepti0.35131847
87MP0005319_abnormal_enzyme/_coenzyme0.35085861
88MP0005503_abnormal_tendon_morphology0.34984298
89MP0003948_abnormal_gas_homeostasis0.32953745
90MP0009115_abnormal_fat_cell0.32308199
91MP0005451_abnormal_body_composition0.31728742
92MP0000230_abnormal_systemic_arterial0.28913883
93MP0005423_abnormal_somatic_nervous0.27983376
94MP0005332_abnormal_amino_acid0.27694838
95MP0008438_abnormal_cutaneous_collagen0.24950613
96MP0005165_increased_susceptibility_to0.24745083
97* MP0005376_homeostasis/metabolism_phenot0.24513153
98MP0005535_abnormal_body_temperature0.24425591
99MP0003567_abnormal_fetal_cardiomyocyte0.24313095
100MP0005166_decreased_susceptibility_to0.24157869
101MP0002118_abnormal_lipid_homeostasis0.23757457
102MP0004085_abnormal_heartbeat0.23754702
103MP0008770_decreased_survivor_rate0.23708828
104MP0001943_abnormal_respiration0.22252439
105MP0005187_abnormal_penis_morphology0.21903473
106MP0003195_calcinosis0.21900938
107MP0004858_abnormal_nervous_system0.21119252
108MP0003828_pulmonary_edema0.20770994
109MP0006276_abnormal_autonomic_nervous0.20614675
110MP0002128_abnormal_blood_circulation0.20429010
111MP0001853_heart_inflammation0.20128521
112MP0003385_abnormal_body_wall0.20036493
113* MP0002066_abnormal_motor_capabilities/c0.19943321
114MP0000427_abnormal_hair_cycle0.18429797
115MP0002249_abnormal_larynx_morphology0.18217735
116MP0010678_abnormal_skin_adnexa0.16855292
117MP0002109_abnormal_limb_morphology0.16753536
118MP0002932_abnormal_joint_morphology0.16587132
119MP0002067_abnormal_sensory_capabilities0.14957655
120MP0004197_abnormal_fetal_growth/weight/0.14131140
121MP0003941_abnormal_skin_development0.12845397
122MP0002876_abnormal_thyroid_physiology0.12395294
123MP0005645_abnormal_hypothalamus_physiol0.12226262

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.92643472
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.55308120
3Nemaline bodies (HP:0003798)8.99355362
4Exercise-induced myalgia (HP:0003738)8.88259224
5Exercise-induced muscle cramps (HP:0003710)8.14520640
6Distal arthrogryposis (HP:0005684)7.75722838
7Type 1 muscle fiber predominance (HP:0003803)7.36230904
8Muscle hypertrophy of the lower extremities (HP:0008968)6.90988932
9Myopathic facies (HP:0002058)6.83507877
10Round ear (HP:0100830)6.45166668
11Ulnar deviation of the wrist (HP:0003049)6.33462379
12Calf muscle hypertrophy (HP:0008981)6.08697427
13Calcaneovalgus deformity (HP:0001848)5.53249106
14Difficulty running (HP:0009046)5.42710062
15Myoglobinuria (HP:0002913)5.29559044
16Muscle fiber splitting (HP:0003555)5.18154049
17Absent phalangeal crease (HP:0006109)5.13197805
18Deformed tarsal bones (HP:0008119)5.08616245
19Muscle stiffness (HP:0003552)4.85355380
20Hyporeflexia of lower limbs (HP:0002600)4.75088225
21EMG: myopathic abnormalities (HP:0003458)4.51589974
22Rhabdomyolysis (HP:0003201)4.47509231
23Increased connective tissue (HP:0009025)4.39193418
24Abnormal finger flexion creases (HP:0006143)4.29951711
25Myotonia (HP:0002486)4.16250276
26Abnormality of the calf musculature (HP:0001430)4.03748810
27Abnormality of skeletal muscle fiber size (HP:0012084)3.81021588
28Subaortic stenosis (HP:0001682)3.62001144
29Abnormality of the left ventricular outflow tract (HP:0011103)3.62001144
30Rimmed vacuoles (HP:0003805)3.53806211
31Malignant hyperthermia (HP:0002047)3.52266030
32Neck muscle weakness (HP:0000467)3.51894319
33Increased variability in muscle fiber diameter (HP:0003557)3.39291788
34Abnormality of the calcaneus (HP:0008364)3.35166467
35Difficulty climbing stairs (HP:0003551)3.29590340
36Frequent falls (HP:0002359)3.26079751
37Shoulder girdle muscle weakness (HP:0003547)3.25554952
38Pelvic girdle muscle weakness (HP:0003749)3.25262100
39Abnormality of the musculature of the pelvis (HP:0001469)3.13739459
40Abnormality of the hip-girdle musculature (HP:0001445)3.13739459
41Areflexia of lower limbs (HP:0002522)3.12197110
42Hyperkalemia (HP:0002153)3.03126368
43Asymmetric septal hypertrophy (HP:0001670)2.83989461
44Slender build (HP:0001533)2.76120801
45Bundle branch block (HP:0011710)2.75924576
46Paralysis (HP:0003470)2.63268871
47Sudden death (HP:0001699)2.55619571
48Fatigable weakness (HP:0003473)2.53901065
49Abnormality of the neuromuscular junction (HP:0003398)2.53901065
50EMG: neuropathic changes (HP:0003445)2.48373559
51Distal lower limb muscle weakness (HP:0009053)2.45785972
52Muscular dystrophy (HP:0003560)2.36167091
53Mildly elevated creatine phosphokinase (HP:0008180)2.27171222
54Hypoplastic ischia (HP:0003175)2.22775160
55Limb-girdle muscle weakness (HP:0003325)2.22481086
56Generalized muscle weakness (HP:0003324)2.22453552
57Metatarsus adductus (HP:0001840)2.21634078
58Nonprogressive disorder (HP:0003680)2.16337729
59Spinal rigidity (HP:0003306)2.16246562
60Bulbar palsy (HP:0001283)2.15673143
61Ulnar deviation of finger (HP:0009465)2.15445004
62Proximal amyotrophy (HP:0007126)2.13697760
63Centrally nucleated skeletal muscle fibers (HP:0003687)2.10936918
64Abnormality of the shoulder girdle musculature (HP:0001435)2.04598994
65Facial diplegia (HP:0001349)2.00872704
66Scapular winging (HP:0003691)1.98834531
67Gowers sign (HP:0003391)1.95612838
68Abnormality of the foot musculature (HP:0001436)1.95059741
69Abnormality of the ischium (HP:0003174)1.94697165
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90721491
71Limb-girdle muscle atrophy (HP:0003797)1.90310833
72Distal lower limb amyotrophy (HP:0008944)1.87809597
73Weak cry (HP:0001612)1.85108154
74Popliteal pterygium (HP:0009756)1.84928786
75Progressive muscle weakness (HP:0003323)1.80996583
76Foot dorsiflexor weakness (HP:0009027)1.80407942
77Achilles tendon contracture (HP:0001771)1.79717122
78Waddling gait (HP:0002515)1.79341213
79Heart block (HP:0012722)1.77485383
80Tarsal synostosis (HP:0008368)1.73719166
81Fetal akinesia sequence (HP:0001989)1.69014340
82Ragged-red muscle fibers (HP:0003200)1.68731480
83Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.68309247
84Abnormal atrioventricular conduction (HP:0005150)1.66841515
85Ventricular tachycardia (HP:0004756)1.64843029
86Increased purine levels (HP:0004368)1.63406077
87Hyperuricemia (HP:0002149)1.63406077
88Abnormality of the Achilles tendon (HP:0005109)1.63359792
89Increased density of long bones (HP:0006392)1.63054726
90Stridor (HP:0010307)1.61215954
91Type 2 muscle fiber atrophy (HP:0003554)1.60668210
92Cholelithiasis (HP:0001081)1.59459661
93Short palpebral fissure (HP:0012745)1.59187435
94Synostosis involving bones of the lower limbs (HP:0009138)1.56233138
95Synostosis involving bones of the feet (HP:0009140)1.56233138
96Abnormality of potassium homeostasis (HP:0011042)1.55927295
97Adducted thumb (HP:0001181)1.53945007
98Gout (HP:0001997)1.53855321
99Hip contracture (HP:0003273)1.52747216
100Limited hip movement (HP:0008800)1.51458869
101Increased intramyocellular lipid droplets (HP:0012240)1.48983253
102Muscle fiber atrophy (HP:0100295)1.48907342
103Respiratory insufficiency due to muscle weakness (HP:0002747)1.48063430
104Oligomenorrhea (HP:0000876)1.47838437
105Ventricular arrhythmia (HP:0004308)1.47132267
106Congenital hip dislocation (HP:0001374)1.43609753
107Exercise intolerance (HP:0003546)1.42464382
108Long clavicles (HP:0000890)1.41913643
109Lipoatrophy (HP:0100578)1.40974855
110Abnormal gallbladder morphology (HP:0012437)1.40470906
111Lower limb amyotrophy (HP:0007210)1.38305332
112Dilated cardiomyopathy (HP:0001644)1.38257371
113Increased muscle lipid content (HP:0009058)1.37780276
114Abnormality of placental membranes (HP:0011409)1.33340880
115Amniotic constriction ring (HP:0009775)1.33340880
116Steppage gait (HP:0003376)1.30684260
117Breech presentation (HP:0001623)1.22463737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.62814117
2TTN6.28401088
3PHKG15.75611053
4PHKG25.75611053
5NME14.47897484
6PIK3CG3.73395413
7MAP2K32.98502768
8NEK12.36385874
9MAP3K72.15183724
10PINK12.05121309
11PDK41.85182105
12PDK31.85182105
13TRIB31.75478636
14PIK3CA1.70053451
15DMPK1.68786626
16MAP2K41.66958070
17MAPK121.63078906
18BCKDK1.53199360
19MAP2K61.47147121
20PDK21.24793096
21MUSK1.15939995
22MAP3K30.96898894
23MARK10.94909765
24PRKAA20.91923011
25NEK90.90766369
26MAPKAPK30.86280882
27PRKAA10.84891420
28STK240.81266447
29TAOK20.78890382
30ERBB30.75268129
31TRPM70.74052518
32ZAK0.68771299
33MAP3K130.65116290
34MAPK110.64000030
35PKN20.60797815
36MAP3K110.59002544
37CAMK40.58553568
38SIK10.55924968
39CAMK2G0.55100618
40AKT20.54586229
41TAOK10.52229044
42EPHB10.47347521
43RIPK10.45300070
44LIMK10.44504748
45ILK0.42936316
46CAMK10.40661324
47CAMK2B0.39549263
48CAMK2A0.39470091
49PTK60.38127601
50EEF2K0.33801614
51MAP3K60.33379383
52SGK10.33041485
53TBK10.30589829
54SGK20.30300331
55KSR20.28560382
56MAP3K50.28427561
57PRKACB0.27572588
58PKN10.27053134
59PRKG10.26817052
60RPS6KB10.26382326
61MAPK130.26233798
62MAP3K10.24871882
63RPS6KA30.23965967
64MAP3K100.23560156
65CDK190.21675351
66MAPK40.20155132
67MAPK70.19493354
68PRPF4B0.19273834
69ARAF0.18959386
70PRKACA0.18705838
71MARK20.17825816
72ROCK10.16607786
73PDPK10.15374716
74CAMK1G0.15365679
75TIE10.15350550
76INSRR0.14943843
77TYK20.14895474
78DAPK20.14280967
79PRKD10.13359224
80MAP2K10.13217313
81PDK10.13028486
82LATS10.12268472
83RPS6KL10.12172837
84RPS6KC10.12172837
85SGK4940.12163331
86SGK2230.12163331
87PAK60.10350446
88TGFBR20.09922320
89RAF10.09629452
90ZAP700.09619730
91MOS0.08715368
92RPS6KA60.08365323
93RPS6KA10.07831281
94LATS20.07238951
95MARK30.07145899
96DYRK1B0.06949192
97FGFR10.06861337
98BRAF0.06499628
99BMX0.06408109
100LRRK20.05628406
101NLK0.05574219
102PRKACG0.04858192
103MAPK100.03992640
104MST1R0.03310775
105ERN10.03189265
106SGK30.03159724
107GSK3A0.03064042
108CAMK2D0.03004359
109JAK20.02904304
110MTOR0.02532183
111GSK3B0.02029543
112STK110.01925539
113CSNK1D0.01834558
114ICK0.01774004
115CCNB10.01579656
116PTK2B0.01481803
117MAPK80.01292706
118KSR10.00841652
119RET-0.0322443
120MAPK9-0.0254948
121RPS6KB2-0.0246570
122FER-0.0208607
123PRKDC-0.0188632
124ROCK2-0.0183257
125RPS6KA2-0.0142896
126FLT3-0.0035921

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.24149910
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.22611635
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.70949991
4Cardiac muscle contraction_Homo sapiens_hsa042603.63199897
5Dilated cardiomyopathy_Homo sapiens_hsa054143.34540169
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.26457220
7Starch and sucrose metabolism_Homo sapiens_hsa005003.17876448
8Glucagon signaling pathway_Homo sapiens_hsa049222.48594000
9Circadian rhythm_Homo sapiens_hsa047102.45691430
10Insulin signaling pathway_Homo sapiens_hsa049102.36131263
11Propanoate metabolism_Homo sapiens_hsa006402.33161178
12Oxytocin signaling pathway_Homo sapiens_hsa049212.32387629
13Carbon metabolism_Homo sapiens_hsa012002.21447537
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.20888171
15Insulin resistance_Homo sapiens_hsa049312.18347219
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90764289
17Galactose metabolism_Homo sapiens_hsa000521.90009965
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.81913013
19Calcium signaling pathway_Homo sapiens_hsa040201.76228650
20AMPK signaling pathway_Homo sapiens_hsa041521.75743360
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75463075
22Parkinsons disease_Homo sapiens_hsa050121.70776146
23Fructose and mannose metabolism_Homo sapiens_hsa000511.67556199
24Alzheimers disease_Homo sapiens_hsa050101.63003237
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60786192
26Biosynthesis of amino acids_Homo sapiens_hsa012301.55703029
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54910778
28Pyruvate metabolism_Homo sapiens_hsa006201.41827142
29Oxidative phosphorylation_Homo sapiens_hsa001901.40787295
30Tight junction_Homo sapiens_hsa045301.37657145
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33631852
32Viral myocarditis_Homo sapiens_hsa054161.31685389
33Arginine and proline metabolism_Homo sapiens_hsa003301.30843094
34Fatty acid degradation_Homo sapiens_hsa000711.30760278
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28345055
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25976425
37Pentose phosphate pathway_Homo sapiens_hsa000301.24099809
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.10580576
39Gastric acid secretion_Homo sapiens_hsa049711.06527113
40Focal adhesion_Homo sapiens_hsa045101.03438572
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02278552
42GnRH signaling pathway_Homo sapiens_hsa049120.99135060
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98748355
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.96522842
45FoxO signaling pathway_Homo sapiens_hsa040680.94129386
46Fatty acid metabolism_Homo sapiens_hsa012120.93509934
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86686896
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78914678
49Arginine biosynthesis_Homo sapiens_hsa002200.78603916
50HIF-1 signaling pathway_Homo sapiens_hsa040660.75585654
51mTOR signaling pathway_Homo sapiens_hsa041500.73753844
52VEGF signaling pathway_Homo sapiens_hsa043700.72033658
53Renin secretion_Homo sapiens_hsa049240.67531123
54Huntingtons disease_Homo sapiens_hsa050160.66703785
55MAPK signaling pathway_Homo sapiens_hsa040100.64889097
56Fatty acid biosynthesis_Homo sapiens_hsa000610.61192850
57Platelet activation_Homo sapiens_hsa046110.55795302
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52911899
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52423912
60PPAR signaling pathway_Homo sapiens_hsa033200.51475802
61Insulin secretion_Homo sapiens_hsa049110.49856243
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.48203799
63Type II diabetes mellitus_Homo sapiens_hsa049300.45637361
64beta-Alanine metabolism_Homo sapiens_hsa004100.44461398
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44265165
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44098479
67Salivary secretion_Homo sapiens_hsa049700.42124761
68Amoebiasis_Homo sapiens_hsa051460.41799140
69Adherens junction_Homo sapiens_hsa045200.38293672
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36426582
71Proteoglycans in cancer_Homo sapiens_hsa052050.35698782
72Tryptophan metabolism_Homo sapiens_hsa003800.34111932
73Long-term depression_Homo sapiens_hsa047300.33214943
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29870838
75Lysine degradation_Homo sapiens_hsa003100.29838104
76Butanoate metabolism_Homo sapiens_hsa006500.29788209
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29167607
78Glioma_Homo sapiens_hsa052140.27177694
79Histidine metabolism_Homo sapiens_hsa003400.25061214
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24934114
81Renal cell carcinoma_Homo sapiens_hsa052110.24882211
82Regulation of autophagy_Homo sapiens_hsa041400.24840732
83Amphetamine addiction_Homo sapiens_hsa050310.22624967
84cAMP signaling pathway_Homo sapiens_hsa040240.22346963
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19319081
86Tyrosine metabolism_Homo sapiens_hsa003500.18112148
87Phenylalanine metabolism_Homo sapiens_hsa003600.17026755
88Cholinergic synapse_Homo sapiens_hsa047250.16865032
89Thyroid cancer_Homo sapiens_hsa052160.16577545
90Pancreatic secretion_Homo sapiens_hsa049720.15955851
91Nitrogen metabolism_Homo sapiens_hsa009100.14511469
92Fatty acid elongation_Homo sapiens_hsa000620.13628602
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12092174
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11756485
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11533724
96Prolactin signaling pathway_Homo sapiens_hsa049170.11511853
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10861967
98Peroxisome_Homo sapiens_hsa041460.10846378
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10012714
100Long-term potentiation_Homo sapiens_hsa047200.09996580
101Circadian entrainment_Homo sapiens_hsa047130.09816506
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09600635
103Sulfur metabolism_Homo sapiens_hsa009200.09377487
104Oocyte meiosis_Homo sapiens_hsa041140.09257076
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09178212
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.09010022
107Melanogenesis_Homo sapiens_hsa049160.08502106
108Metabolic pathways_Homo sapiens_hsa011000.08474278
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.08230109
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.07751073
111Bile secretion_Homo sapiens_hsa049760.07011637
112Olfactory transduction_Homo sapiens_hsa047400.06865177
113Sulfur relay system_Homo sapiens_hsa041220.06330045
114ECM-receptor interaction_Homo sapiens_hsa045120.05793545
115Purine metabolism_Homo sapiens_hsa002300.05613708
116Linoleic acid metabolism_Homo sapiens_hsa005910.05419163
117ABC transporters_Homo sapiens_hsa020100.03592879

Most similar genes based on co-expression Upload to Enrichr

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