MYPOP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.90403193
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89156815
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62480749
4locomotory exploration behavior (GO:0035641)5.61513549
5synaptic vesicle exocytosis (GO:0016079)5.19559507
6regulation of synaptic vesicle exocytosis (GO:2000300)5.13826523
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12693380
8vocalization behavior (GO:0071625)5.00092635
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86351639
10neuronal action potential propagation (GO:0019227)4.79328659
11glutamate secretion (GO:0014047)4.73942115
12regulation of synaptic vesicle transport (GO:1902803)4.47478112
13regulation of glutamate receptor signaling pathway (GO:1900449)4.46454268
14neuron cell-cell adhesion (GO:0007158)4.37695405
15protein localization to synapse (GO:0035418)4.36206831
16neurotransmitter secretion (GO:0007269)4.34302801
17regulation of synapse structural plasticity (GO:0051823)4.30621815
18layer formation in cerebral cortex (GO:0021819)4.27639047
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.23263762
20exploration behavior (GO:0035640)4.22046977
21regulation of neuronal synaptic plasticity (GO:0048168)4.21442853
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.21093436
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16071182
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.14497729
25regulation of early endosome to late endosome transport (GO:2000641)4.06172087
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.05098875
27negative regulation of erythrocyte differentiation (GO:0045647)3.95344444
28ribosomal small subunit biogenesis (GO:0042274)3.83950683
29neuromuscular process controlling posture (GO:0050884)3.82460325
30positive regulation of synaptic transmission, GABAergic (GO:0032230)3.78893710
31proline transport (GO:0015824)3.74455155
32gamma-aminobutyric acid transport (GO:0015812)3.74074962
33regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73898109
34dendritic spine morphogenesis (GO:0060997)3.71031258
35synaptic transmission, glutamatergic (GO:0035249)3.69028712
36cellular potassium ion homeostasis (GO:0030007)3.68875624
37long-term memory (GO:0007616)3.68795316
38sodium ion export (GO:0071436)3.59035877
39positive regulation of protein dephosphorylation (GO:0035307)3.56430179
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54876396
41neurotransmitter transport (GO:0006836)3.54502272
42positive regulation of membrane potential (GO:0045838)3.53912264
43glycine transport (GO:0015816)3.53780980
44neuron-neuron synaptic transmission (GO:0007270)3.53686486
45activation of protein kinase A activity (GO:0034199)3.53286849
46glutamate receptor signaling pathway (GO:0007215)3.47770141
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47037660
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44513667
49tooth mineralization (GO:0034505)3.43144567
50regulation of vesicle fusion (GO:0031338)3.42723806
51neuromuscular process controlling balance (GO:0050885)3.39916617
52transmission of nerve impulse (GO:0019226)3.39695227
53positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.38319575
54regulation of postsynaptic membrane potential (GO:0060078)3.36447655
55regulation of neurotransmitter secretion (GO:0046928)3.34776011
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34263569
57regulation of synaptic plasticity (GO:0048167)3.34127165
58NIK/NF-kappaB signaling (GO:0038061)3.31726762
59cerebellar Purkinje cell differentiation (GO:0021702)3.31550244
60neurotransmitter-gated ion channel clustering (GO:0072578)3.28950625
61neuronal ion channel clustering (GO:0045161)3.26075866
62regulation of neurotransmitter levels (GO:0001505)3.25781163
63neuron recognition (GO:0008038)3.23617842
64regulation of dendritic spine morphogenesis (GO:0061001)3.23420016
65protein localization to endosome (GO:0036010)3.21288966
66synaptic vesicle endocytosis (GO:0048488)3.21251626
67calcium ion-dependent exocytosis (GO:0017156)3.19411215
68protein maturation by protein folding (GO:0022417)3.18592840
69regulation of ARF protein signal transduction (GO:0032012)3.16543734
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14544766
71cell migration in hindbrain (GO:0021535)3.14127902
72auditory behavior (GO:0031223)3.13992267
73creatine metabolic process (GO:0006600)3.13478515
74positive regulation of synapse maturation (GO:0090129)3.12967832
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12181055
76regulation of neurotransmitter transport (GO:0051588)3.11217851
77membrane depolarization during action potential (GO:0086010)3.10945897
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09812670
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08311132
80gamma-aminobutyric acid signaling pathway (GO:0007214)3.06924067
81focal adhesion assembly (GO:0048041)3.05608902
82cell-substrate adherens junction assembly (GO:0007045)3.05608902
83long-term synaptic potentiation (GO:0060291)3.05424438
84response to acidic pH (GO:0010447)3.04595574
85mating behavior (GO:0007617)3.04391927
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04168350
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03859883
88membrane depolarization (GO:0051899)3.03069794
89response to parathyroid hormone (GO:0071107)3.01914835
90membrane hyperpolarization (GO:0060081)3.01686412
91modulation by virus of host process (GO:0019054)3.00107929
92prepulse inhibition (GO:0060134)2.99838926
93cell-cell junction maintenance (GO:0045217)2.98781123
94cell communication by electrical coupling (GO:0010644)2.98647322
95adherens junction assembly (GO:0034333)2.98407680
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.98002489
97modulation by symbiont of host cellular process (GO:0044068)2.95124526
98intraspecies interaction between organisms (GO:0051703)2.94907864
99social behavior (GO:0035176)2.94907864
100regulation of oxidative phosphorylation (GO:0002082)2.93618501
101response to auditory stimulus (GO:0010996)2.93325458
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90527105
103positive regulation of neurotransmitter transport (GO:0051590)2.89828346
104regulation of synaptic transmission (GO:0050804)2.89258377
105dendrite morphogenesis (GO:0048813)2.88862609
106activation of Rac GTPase activity (GO:0032863)2.88552989
107positive regulation of dendritic spine development (GO:0060999)2.87693003
108positive regulation of synaptic transmission (GO:0050806)2.86853227
109regulation of protein dephosphorylation (GO:0035304)2.85937538
110cerebellar granule cell differentiation (GO:0021707)2.85697718
111neuromuscular process (GO:0050905)2.85436767
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83454101
113adult walking behavior (GO:0007628)2.82921972
114regulation of synaptic transmission, GABAergic (GO:0032228)2.82287966
115cerebellar Purkinje cell layer development (GO:0021680)2.82219744
116regulation of dendritic spine development (GO:0060998)2.82128278
117axonal fasciculation (GO:0007413)2.81793655
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.81652808
119regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80618215
120learning (GO:0007612)2.80431394
121postsynaptic membrane organization (GO:0001941)2.80185372
122regulation of voltage-gated calcium channel activity (GO:1901385)2.79329005
123synaptic transmission (GO:0007268)2.78453364
124regulation of synapse maturation (GO:0090128)2.76404621
125vesicle transport along microtubule (GO:0047496)2.76383738
126regulation of synaptic transmission, dopaminergic (GO:0032225)2.75179567
127apoptotic process involved in morphogenesis (GO:0060561)2.74719347
128positive regulation of neurotransmitter secretion (GO:0001956)2.73391960
129regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.70990387
130negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69957526
131signal complex assembly (GO:0007172)2.68165595
132protein targeting to plasma membrane (GO:0072661)2.67470222
133dopamine receptor signaling pathway (GO:0007212)2.64331393
134activation of MAPKKK activity (GO:0000185)2.64230723
135endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64187006
136negative regulation of cell size (GO:0045792)2.64116607
137amyloid precursor protein catabolic process (GO:0042987)2.63968815
138positive regulation of protein sumoylation (GO:0033235)2.60616894
139adenosine receptor signaling pathway (GO:0001973)2.58229026
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.55854481
141regulation of chromatin binding (GO:0035561)2.55118842
142viral transcription (GO:0019083)2.53605638
143positive regulation of myotube differentiation (GO:0010831)2.53354094
144outflow tract septum morphogenesis (GO:0003148)2.52389574
145phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50995890
146regulation of ARF GTPase activity (GO:0032312)2.46845922
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.46353125
148negative regulation of cell killing (GO:0031342)2.46353125
149regulation of extracellular matrix disassembly (GO:0010715)2.45635123
150mannose metabolic process (GO:0006013)2.44151736
151mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43969458
152protein retention in ER lumen (GO:0006621)2.41133190
153regulation of actin cytoskeleton reorganization (GO:2000249)2.40799024
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.39518096
155intracellular estrogen receptor signaling pathway (GO:0030520)2.35596348
156response to peptidoglycan (GO:0032494)2.34978737
157positive regulation of fibroblast migration (GO:0010763)2.34941004
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.32288724
159positive regulation of actin cytoskeleton reorganization (GO:2000251)2.32010755
160calcium-mediated signaling using intracellular calcium source (GO:0035584)2.31981334
161regulation of T-helper 2 cell differentiation (GO:0045628)2.31291971
162modulation by symbiont of host immune response (GO:0052553)2.30570800
163positive regulation by symbiont of host defense response (GO:0052509)2.30570800
164modulation by symbiont of host defense response (GO:0052031)2.30570800
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30570800
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.30570800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95631375
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.13655735
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98231599
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.96323800
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94731747
6REST_21632747_ChIP-Seq_MESCs_Mouse2.90072314
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89235786
8VDR_21846776_ChIP-Seq_THP-1_Human2.77414305
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74752657
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74752657
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.68433643
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65165466
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63330405
14GBX2_23144817_ChIP-Seq_PC3_Human2.49573513
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48151997
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.47023110
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46605916
18DROSHA_22980978_ChIP-Seq_HELA_Human2.46133747
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45398210
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45261563
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.45064707
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.40891248
23MYC_22102868_ChIP-Seq_BL_Human2.35048300
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33351095
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32947169
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29978556
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28199037
28* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25800348
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.25741590
30RACK7_27058665_Chip-Seq_MCF-7_Human2.20794917
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18630749
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15036883
33TET1_21451524_ChIP-Seq_MESCs_Mouse2.08539695
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.03788525
35SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01939694
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00698583
37P68_20966046_ChIP-Seq_HELA_Human1.91120415
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90543381
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88853662
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87067536
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84718689
42TCF7_22412390_ChIP-Seq_EML_Mouse1.83632582
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74202891
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71315953
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.70493785
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.66020674
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65115119
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59285949
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58725631
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57417636
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55025182
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52371168
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.50224144
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49522457
55KDM2B_26808549_Chip-Seq_K562_Human1.48429394
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.48199162
57VDR_24763502_ChIP-Seq_THP-1_Human1.47286352
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47060741
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46953139
60CREB1_26743006_Chip-Seq_LNCaP_Human1.46087953
61AR_21572438_ChIP-Seq_LNCaP_Human1.45364836
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43987492
63* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43104129
64ZNF263_19887448_ChIP-Seq_K562_Human1.42214513
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41774196
66ZNF274_21170338_ChIP-Seq_K562_Hela1.41485006
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38815163
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38093601
69MAF_26560356_Chip-Seq_TH2_Human1.37965923
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37852400
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37381873
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36849344
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35723287
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33863688
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33309852
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31149874
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30313150
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30180573
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.28870738
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28826986
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28555131
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.28292761
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27277183
84BCL6_27268052_Chip-Seq_Bcells_Human1.25666819
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24275642
86CTCF_27219007_Chip-Seq_Bcells_Human1.23288062
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.23261223
88BCOR_27268052_Chip-Seq_Bcells_Human1.22221018
89CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21489677
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21213936
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20494044
92MAF_26560356_Chip-Seq_TH1_Human1.20377620
93SMAD4_21799915_ChIP-Seq_A2780_Human1.20361440
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20245526
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.19834481
96SA1_27219007_Chip-Seq_Bcells_Human1.19275037
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19174070
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18822510
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.18803969
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17752501
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15385871
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15254908
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14164215
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12385906
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12196426
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11715806
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10705142
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10502849
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09708397
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09606225
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.09353714
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09165285
113AR_19668381_ChIP-Seq_PC3_Human1.08875876
114UTX_26944678_Chip-Seq_JUKART_Human1.08574903
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08461699
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06859884
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.06504912
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06499902
119ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05350339
120LXR_22292898_ChIP-Seq_THP-1_Human1.03170752
121TAF15_26573619_Chip-Seq_HEK293_Human1.02496316
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01790815
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01621339
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01512874
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.01314525
126CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00635279
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99916551
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99788371
129CTCF_21964334_Chip-Seq_Bcells_Human0.99439416
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.99296287
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99142743
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98403843
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98349912
134ETS1_21867929_ChIP-Seq_TH2_Mouse0.97600701
135RNF2_27304074_Chip-Seq_NSC_Mouse0.97545078
136PHF8_20622854_ChIP-Seq_HELA_Human0.97224065
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96993011
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96856731
139ATF3_27146783_Chip-Seq_COLON_Human0.96408953
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95453759
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.93832256
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93739711
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93090645
144SMC4_20622854_ChIP-Seq_HELA_Human0.91929319
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90536811
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89733983
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89608861
148* KLF4_19829295_ChIP-Seq_ESCs_Human0.89595310
149AR_25329375_ChIP-Seq_VCAP_Human0.88443063
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.87464606
151STAT3_23295773_ChIP-Seq_U87_Human0.87151972
152KDM2B_26808549_Chip-Seq_DND41_Human0.86676583
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86460011
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.86309563
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85598562
156OCT4_19829295_ChIP-Seq_ESCs_Human0.85474119
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.85152632
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84327716
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83577965
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82929197
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82693623
162TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82085502
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81549794
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.81516739
165GATA1_26923725_Chip-Seq_HPCs_Mouse0.79956643
166* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79244239
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78894423
168* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78766942
169AHR_22903824_ChIP-Seq_MCF-7_Human0.78608586
170* TCF4_23295773_ChIP-Seq_U87_Human0.76232217
171SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74100807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.29367293
2MP0003880_abnormal_central_pattern4.76517312
3MP0003635_abnormal_synaptic_transmissio4.04001258
4MP0004270_analgesia3.59282403
5MP0005451_abnormal_body_composition3.50169898
6MP0003705_abnormal_hypodermis_morpholog3.25872272
7MP0009745_abnormal_behavioral_response3.25583141
8MP0002063_abnormal_learning/memory/cond3.13167456
9MP0002064_seizures3.09344481
10MP0002822_catalepsy3.07000199
11MP0004510_myositis3.02583775
12MP0009046_muscle_twitch2.95585426
13MP0003123_paternal_imprinting2.88255663
14MP0001968_abnormal_touch/_nociception2.84343137
15MP0009379_abnormal_foot_pigmentation2.72767711
16MP0002272_abnormal_nervous_system2.65185341
17MP0005058_abnormal_lysosome_morphology2.64155830
18MP0002572_abnormal_emotion/affect_behav2.63284677
19MP0002734_abnormal_mechanical_nocicepti2.62841939
20MP0000678_abnormal_parathyroid_gland2.55510760
21MP0005423_abnormal_somatic_nervous2.39243442
22MP0001486_abnormal_startle_reflex2.36966940
23MP0002733_abnormal_thermal_nociception2.30010876
24MP0003303_peritoneal_inflammation2.23605087
25MP0002909_abnormal_adrenal_gland2.22531690
26MP0001970_abnormal_pain_threshold2.22424012
27MP0003329_amyloid_beta_deposits2.19972324
28MP0001501_abnormal_sleep_pattern2.18173043
29MP0002736_abnormal_nociception_after2.16687425
30MP0008569_lethality_at_weaning2.11685835
31MP0002249_abnormal_larynx_morphology2.11500150
32MP0008260_abnormal_autophagy2.06641035
33MP0001440_abnormal_grooming_behavior2.00696931
34MP0009780_abnormal_chondrocyte_physiolo1.99312843
35MP0004858_abnormal_nervous_system1.98305504
36MP0002735_abnormal_chemical_nociception1.96689325
37MP0009840_abnormal_foam_cell1.86203604
38MP0002067_abnormal_sensory_capabilities1.79417337
39MP0004811_abnormal_neuron_physiology1.76582408
40MP0006276_abnormal_autonomic_nervous1.76339891
41MP0000013_abnormal_adipose_tissue1.70511792
42MP0005410_abnormal_fertilization1.70296935
43MP0000955_abnormal_spinal_cord1.65152975
44MP0005623_abnormal_meninges_morphology1.60607596
45MP0000759_abnormal_skeletal_muscle1.60246533
46MP0004185_abnormal_adipocyte_glucose1.59830773
47MP0002184_abnormal_innervation1.58759109
48MP0002877_abnormal_melanocyte_morpholog1.57838715
49MP0002557_abnormal_social/conspecific_i1.57262086
50MP0003122_maternal_imprinting1.56331215
51MP0005386_behavior/neurological_phenoty1.55637074
52MP0004924_abnormal_behavior1.55637074
53MP0003879_abnormal_hair_cell1.54200824
54MP0010030_abnormal_orbit_morphology1.53023258
55MP0003436_decreased_susceptibility_to1.50295035
56MP0000778_abnormal_nervous_system1.49868419
57MP0002089_abnormal_postnatal_growth/wei1.49066893
58MP0009333_abnormal_splenocyte_physiolog1.46932747
59MP0002066_abnormal_motor_capabilities/c1.43713360
60MP0000750_abnormal_muscle_regeneration1.43543152
61MP0001529_abnormal_vocalization1.39140906
62MP0004142_abnormal_muscle_tone1.38230217
63MP0004885_abnormal_endolymph1.38021231
64MP0002882_abnormal_neuron_morphology1.37271791
65MP0003787_abnormal_imprinting1.34335876
66MP0005646_abnormal_pituitary_gland1.33724475
67MP0003633_abnormal_nervous_system1.33352662
68MP0001984_abnormal_olfaction1.32109521
69MP0000733_abnormal_muscle_development1.26911005
70MP0005645_abnormal_hypothalamus_physiol1.26532561
71MP0002234_abnormal_pharynx_morphology1.24896989
72MP0001346_abnormal_lacrimal_gland1.23727778
73MP0001905_abnormal_dopamine_level1.23444746
74MP0000751_myopathy1.20643845
75MP0004130_abnormal_muscle_cell1.18996782
76MP0000920_abnormal_myelination1.18423824
77MP0004145_abnormal_muscle_electrophysio1.16764830
78MP0003453_abnormal_keratinocyte_physiol1.16388881
79MP0010386_abnormal_urinary_bladder1.16365856
80MP0003283_abnormal_digestive_organ1.15553381
81MP0005375_adipose_tissue_phenotype1.14358881
82MP0008961_abnormal_basal_metabolism1.13044953
83MP0005076_abnormal_cell_differentiation1.09821537
84MP0003631_nervous_system_phenotype1.08224800
85MP0005666_abnormal_adipose_tissue1.08128911
86MP0002152_abnormal_brain_morphology1.07117272
87MP0000681_abnormal_thyroid_gland1.07047193
88MP0005166_decreased_susceptibility_to1.05384753
89MP0009278_abnormal_bone_marrow1.05206389
90MP0004087_abnormal_muscle_fiber1.05071851
91MP0001849_ear_inflammation1.05037325
92MP0003634_abnormal_glial_cell1.04040329
93MP0002837_dystrophic_cardiac_calcinosis1.03426198
94MP0001502_abnormal_circadian_rhythm1.03367715
95MP0006036_abnormal_mitochondrial_physio1.02897738
96MP0003191_abnormal_cellular_cholesterol0.99593847
97MP0003279_aneurysm0.99482023
98MP0002229_neurodegeneration0.97408250
99MP0002269_muscular_atrophy0.94428861
100MP0003690_abnormal_glial_cell0.92585699
101MP0005409_darkened_coat_color0.92477572
102MP0002796_impaired_skin_barrier0.92431922
103MP0000604_amyloidosis0.92244946
104MP0008874_decreased_physiological_sensi0.91701294
105MP0002069_abnormal_eating/drinking_beha0.89913981
106MP0002332_abnormal_exercise_endurance0.87883846
107MP0008872_abnormal_physiological_respon0.87196917
108MP0004043_abnormal_pH_regulation0.85969912
109MP0002653_abnormal_ependyma_morphology0.84652795
110MP0002106_abnormal_muscle_physiology0.83657782
111MP0004742_abnormal_vestibular_system0.83320830
112MP0000749_muscle_degeneration0.83027732
113MP0005330_cardiomyopathy0.82393579
114MP0004085_abnormal_heartbeat0.82297999
115MP0000003_abnormal_adipose_tissue0.80977470
116MP0005535_abnormal_body_temperature0.78929665
117MP0000858_altered_metastatic_potential0.78663418
118MP0004233_abnormal_muscle_weight0.78578177
119MP0003075_altered_response_to0.78271610
120MP0001348_abnormal_lacrimal_gland0.76643099
121MP0001853_heart_inflammation0.73890706
122MP0003632_abnormal_nervous_system0.72750728
123MP0000747_muscle_weakness0.70665025
124MP0005394_taste/olfaction_phenotype0.69912320
125MP0005499_abnormal_olfactory_system0.69912320
126MP0000631_abnormal_neuroendocrine_gland0.68870337
127MP0004947_skin_inflammation0.67422318
128MP0010234_abnormal_vibrissa_follicle0.66886561
129MP0003172_abnormal_lysosome_physiology0.66707467
130MP0002752_abnormal_somatic_nervous0.66624768
131MP0001963_abnormal_hearing_physiology0.66602441
132MP0001188_hyperpigmentation0.66549304
133MP0005025_abnormal_response_to0.65960171
134MP0009672_abnormal_birth_weight0.65766340
135MP0005501_abnormal_skin_physiology0.65389193
136MP0001299_abnormal_eye_distance/0.65006530
137MP0003137_abnormal_impulse_conducting0.64972402
138MP0005000_abnormal_immune_tolerance0.63902431
139MP0001533_abnormal_skeleton_physiology0.63064830
140MP0003698_abnormal_male_reproductive0.62662626
141MP0005670_abnormal_white_adipose0.62356536
142MP0002932_abnormal_joint_morphology0.61953975
143MP0005369_muscle_phenotype0.60763390
144MP0001177_atelectasis0.60503590
145MP0001943_abnormal_respiration0.59466361
146MP0002163_abnormal_gland_morphology0.58017396
147MP0003183_abnormal_peptide_metabolism0.57925076
148MP0005551_abnormal_eye_electrophysiolog0.57281882
149MP0002090_abnormal_vision0.57216747
150MP0001485_abnormal_pinna_reflex0.56610136
151MP0004381_abnormal_hair_follicle0.56414556
152MP0010630_abnormal_cardiac_muscle0.56335188
153MP0002998_abnormal_bone_remodeling0.56331652
154MP0003861_abnormal_nervous_system0.54614926
155MP0010769_abnormal_survival0.54055351
156MP0008877_abnormal_DNA_methylation0.53225950
157MP0002638_abnormal_pupillary_reflex0.52718854
158MP0003956_abnormal_body_size0.52437073
159MP0000569_abnormal_digit_pigmentation0.52425183

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.06966428
2Focal motor seizures (HP:0011153)6.65371207
3Focal seizures (HP:0007359)5.30564574
4Visual hallucinations (HP:0002367)5.14736095
5Atonic seizures (HP:0010819)4.75340092
6Supranuclear gaze palsy (HP:0000605)4.44412676
7Epileptic encephalopathy (HP:0200134)4.10250404
8Absence seizures (HP:0002121)3.98312342
9Action tremor (HP:0002345)3.82702244
10Progressive cerebellar ataxia (HP:0002073)3.69943280
11Ankle clonus (HP:0011448)3.60721318
12Obstructive sleep apnea (HP:0002870)3.56956847
13Dialeptic seizures (HP:0011146)3.46649840
14Febrile seizures (HP:0002373)3.43915742
15Double outlet right ventricle (HP:0001719)3.43113776
16Congenital malformation of the right heart (HP:0011723)3.43113776
17Generalized tonic-clonic seizures (HP:0002069)3.35761448
18Impaired vibration sensation in the lower limbs (HP:0002166)3.16725397
19Depression (HP:0000716)3.14855359
20Amblyopia (HP:0000646)3.14218344
21Hyperthyroidism (HP:0000836)3.06518000
22Neurofibrillary tangles (HP:0002185)3.01372483
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.98071776
24Dysmetria (HP:0001310)2.97657517
25Achilles tendon contracture (HP:0001771)2.97071156
26Cerebral inclusion bodies (HP:0100314)2.91076193
27Papilledema (HP:0001085)2.88084839
28Anxiety (HP:0000739)2.88046153
29Poor eye contact (HP:0000817)2.87019434
30Urinary bladder sphincter dysfunction (HP:0002839)2.86012341
31Abnormal eating behavior (HP:0100738)2.84551269
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82776491
33Spastic gait (HP:0002064)2.82710172
34Myopathic facies (HP:0002058)2.78190976
35Abnormality of the lower motor neuron (HP:0002366)2.75645859
36Truncus arteriosus (HP:0001660)2.75414307
37Dysdiadochokinesis (HP:0002075)2.74843239
38Postural instability (HP:0002172)2.72637422
39Megalencephaly (HP:0001355)2.72216918
40Impaired social interactions (HP:0000735)2.69019909
41Abnormal social behavior (HP:0012433)2.69019909
42Abnormality of the Achilles tendon (HP:0005109)2.66040159
43Broad-based gait (HP:0002136)2.65967721
44Hyperacusis (HP:0010780)2.64624863
45Truncal ataxia (HP:0002078)2.64466555
46Urinary urgency (HP:0000012)2.62449378
47Gaze-evoked nystagmus (HP:0000640)2.61670829
48Hemiparesis (HP:0001269)2.56803076
49Torticollis (HP:0000473)2.55197984
50Impaired smooth pursuit (HP:0007772)2.52949260
51Abnormality of skeletal muscle fiber size (HP:0012084)2.52857646
52Hyperparathyroidism (HP:0000843)2.52794342
53Insidious onset (HP:0003587)2.52641969
54Termporal pattern (HP:0011008)2.52641969
55Increased variability in muscle fiber diameter (HP:0003557)2.51246349
56Exercise-induced myalgia (HP:0003738)2.49019754
57Pheochromocytoma (HP:0002666)2.49009252
58Hypokinesia (HP:0002375)2.48332413
59Type 1 muscle fiber predominance (HP:0003803)2.48158460
60Vertebral compression fractures (HP:0002953)2.47035156
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45588601
62Mutism (HP:0002300)2.44307640
63Stridor (HP:0010307)2.43097303
64Distal lower limb muscle weakness (HP:0009053)2.41262115
65Ventricular fibrillation (HP:0001663)2.40244841
66Bundle branch block (HP:0011710)2.38485188
67Annular pancreas (HP:0001734)2.37145769
68Genetic anticipation (HP:0003743)2.36888972
69Abnormality of the corticospinal tract (HP:0002492)2.36828376
70Agitation (HP:0000713)2.36728433
71Rapidly progressive (HP:0003678)2.36084208
72Hemiplegia (HP:0002301)2.36062744
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33452971
74Focal dystonia (HP:0004373)2.31427104
75Muscle fiber inclusion bodies (HP:0100299)2.30254476
76Bulbar palsy (HP:0001283)2.29286006
77Hypercortisolism (HP:0001578)2.28069349
78Neuronal loss in central nervous system (HP:0002529)2.27748600
79Bradykinesia (HP:0002067)2.27584357
80Failure to thrive in infancy (HP:0001531)2.25078380
81Insomnia (HP:0100785)2.24708858
82Long palpebral fissure (HP:0000637)2.24692453
83Intention tremor (HP:0002080)2.22408858
84Round ear (HP:0100830)2.21921498
85Neuroendocrine neoplasm (HP:0100634)2.20867543
86Ragged-red muscle fibers (HP:0003200)2.20177031
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.19646592
88Ankyloglossia (HP:0010296)2.19638352
89Axonal loss (HP:0003447)2.19526909
90Lower limb muscle weakness (HP:0007340)2.19519023
91Stereotypic behavior (HP:0000733)2.18803434
92Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16450788
93Nemaline bodies (HP:0003798)2.16352062
94Craniofacial dystonia (HP:0012179)2.16057940
95Distal lower limb amyotrophy (HP:0008944)2.15670885
96Recurrent bacterial skin infections (HP:0005406)2.14844019
97Increased connective tissue (HP:0009025)2.13170555
98Deep palmar crease (HP:0006191)2.12856154
99EEG with generalized epileptiform discharges (HP:0011198)2.10719726
100Epileptiform EEG discharges (HP:0011182)2.09642873
101Testicular atrophy (HP:0000029)2.09414167
102Delusions (HP:0000746)2.08901547
103Dysmetric saccades (HP:0000641)2.08787145
104Recurrent abscess formation (HP:0002722)2.08725355
105Slow saccadic eye movements (HP:0000514)2.08552598
106Hyperventilation (HP:0002883)2.08542317
107Abnormality of ocular smooth pursuit (HP:0000617)2.08030366
108Hypoventilation (HP:0002791)2.07294311
109Absent/shortened dynein arms (HP:0200106)2.05593507
110Dynein arm defect of respiratory motile cilia (HP:0012255)2.05593507
111Progressive inability to walk (HP:0002505)2.05297529
112Impaired vibratory sensation (HP:0002495)2.05116837
113Hypsarrhythmia (HP:0002521)2.04551050
114Diplopia (HP:0000651)2.02237919
115Abnormality of binocular vision (HP:0011514)2.02237919
116Clonus (HP:0002169)2.02202310
117Abnormality of saccadic eye movements (HP:0000570)2.02089376
118Ulnar deviation of the wrist (HP:0003049)2.01100429
119Scanning speech (HP:0002168)2.00978269
120Pointed chin (HP:0000307)2.00875231
121Abnormal EKG (HP:0003115)2.00263752
122Progressive muscle weakness (HP:0003323)2.00135577
123Degeneration of the lateral corticospinal tracts (HP:0002314)1.99946330
124Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99946330
125Status epilepticus (HP:0002133)1.99490063
126Muscle stiffness (HP:0003552)1.98791940
127Slender build (HP:0001533)1.97800708
128Abnormality of oral frenula (HP:0000190)1.92992447
129Polygenic inheritance (HP:0010982)1.92962106
130Polyphagia (HP:0002591)1.92450920
131Bowel incontinence (HP:0002607)1.92058754
132Abnormality of liposaccharide metabolism (HP:0010968)1.91815336
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.91815336
134Abnormality of glycolipid metabolism (HP:0010969)1.91815336
135Hypertensive crisis (HP:0100735)1.91423338
136Psychosis (HP:0000709)1.91138252
137Abnormality of the tricuspid valve (HP:0001702)1.90865315
138Drooling (HP:0002307)1.90729668
139Excessive salivation (HP:0003781)1.90729668
140Resting tremor (HP:0002322)1.90648747
141Apathy (HP:0000741)1.90209375
142Limb dystonia (HP:0002451)1.90197703
143Distal upper limb amyotrophy (HP:0007149)1.89964003
144Upper limb amyotrophy (HP:0009129)1.89964003
145Generalized hypotonia (HP:0001290)1.88992358
146Diminished motivation (HP:0000745)1.87944158
147Asymmetric septal hypertrophy (HP:0001670)1.87469262
148Abnormality of the aortic arch (HP:0012303)1.87261546
149Dementia (HP:0000726)1.86794912
150Abnormal large intestine physiology (HP:0012700)1.85263268
151Progressive neurologic deterioration (HP:0002344)1.84180511
152EMG: myopathic abnormalities (HP:0003458)1.83719688
153Rigidity (HP:0002063)1.83389460
154Neoplasm of the peripheral nervous system (HP:0100007)1.82572933
155Genu recurvatum (HP:0002816)1.82469239
156Generalized myoclonic seizures (HP:0002123)1.82187504
157Spinal canal stenosis (HP:0003416)1.80678524
158Peripheral hypomyelination (HP:0007182)1.80340357
159Abnormality of macrophages (HP:0004311)1.78729616
160Athetosis (HP:0002305)1.78623707
161Tetraplegia (HP:0002445)1.77654867
162Myotonia (HP:0002486)1.77521127
163Abnormal ventriculo-arterial connection (HP:0011563)1.77431345
164Transposition of the great arteries (HP:0001669)1.77431345
165Abnormal connection of the cardiac segments (HP:0011545)1.77431345
166Gait ataxia (HP:0002066)1.77004862
167Lower limb amyotrophy (HP:0007210)1.76937163
168Dysostosis multiplex (HP:0000943)1.74370172
169Broad distal phalanx of finger (HP:0009836)1.74033939
170Nuclear cataract (HP:0100018)1.72848436
171Hypoplastic left heart (HP:0004383)1.72423514
172Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72148412
173Turricephaly (HP:0000262)1.71955647
174Cerebral aneurysm (HP:0004944)1.69356389
175Generalized amyotrophy (HP:0003700)1.68858886
176Increased serum ferritin (HP:0003281)1.67255933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.91416357
2MAP3K93.73641572
3SMG13.32497184
4PRKD33.26566629
5EPHA43.22849149
6MAP3K42.94879932
7IRAK32.94185431
8PAK62.72684681
9KSR22.63130193
10MINK12.55164728
11SIK12.47246202
12ERN12.40848765
13MAP3K112.33120388
14NME22.30790207
15CAMKK12.13449235
16NTRK12.12173856
17NTRK22.00463413
18MAP2K71.92739357
19MARK11.92244477
20DAPK21.91386006
21ARAF1.84434982
22MAP3K121.84107637
23TAOK21.82051101
24MAP2K41.79709907
25GRK51.73371129
26RIPK41.71994051
27MAP3K21.66090164
28BRAF1.63158651
29TYRO31.62970759
30IRAK21.62877702
31PNCK1.61148237
32EEF2K1.57106204
33TAOK11.54671401
34LATS21.51347971
35UHMK11.49360938
36CDK191.49337938
37MAP2K31.46811298
38STK161.46517091
39CAMKK21.44898738
40CDK51.44789187
41STK381.42027792
42KSR11.32736159
43VRK21.31423834
44SIK21.31410387
45PRKCH1.24448474
46IRAK41.23919652
47TAF11.23412996
48TTN1.22633972
49FES1.17545813
50ICK1.14332331
51DAPK11.13750791
52MAP3K131.09548284
53PRKCG1.08263724
54RET1.06593027
55MAPK121.05647756
56MAP4K11.05625760
57TRIB31.04709865
58MAP3K11.03661077
59STK111.00811096
60CDK121.00398068
61PRKG20.94483622
62WNK10.94354643
63LMTK20.93758695
64CDK150.92372775
65CDK180.91542700
66MARK20.91476609
67CDK140.89628728
68PDPK10.88802402
69PDK10.88387720
70PHKG10.88136907
71PHKG20.88136907
72RAF10.86800126
73PLK20.84462411
74ALK0.84147170
75TESK20.82506066
76CDK11A0.82355498
77OXSR10.82119234
78PAK30.82020562
79MAPK130.81042912
80PTK2B0.80960715
81CAMK2A0.80423041
82PINK10.79615414
83DMPK0.79285076
84RIPK10.78359012
85CAMK10.78271753
86WNK40.77837309
87STK390.77708125
88PRPF4B0.76340103
89MAPK110.75268806
90TNIK0.74560938
91GRK60.74358226
92TNK20.74253001
93CAMK1G0.72966459
94RPS6KA20.72577463
95LRRK20.71859359
96MAP3K30.68476738
97CAMK2B0.66225824
98PDK30.64628514
99PDK40.64628514
100MAP3K100.63443511
101SGK2230.61475586
102SGK4940.61475586
103ABL20.61355800
104MTOR0.60881532
105RPS6KL10.58003226
106RPS6KC10.58003226
107SIK30.57839704
108MAP3K80.57241504
109MAP2K20.56453815
110PDGFRA0.55948104
111AKT20.55931865
112HIPK20.55705161
113ROCK20.54765165
114PTK60.54251039
115TYK20.49599333
116ZAP700.48951248
117MOS0.48922088
118DDR20.48304575
119PKN20.47501798
120DAPK30.47480013
121CAMK2D0.46326780
122MAPK100.45785562
123CAMK2G0.44831782
124CDC42BPA0.44537107
125TESK10.44506460
126PTK20.43399069
127SGK10.42940908
128LIMK10.42724209
129RPS6KA30.41702579
130MAPK40.41122863
131PRKCZ0.41093144
132NME10.41071052
133DYRK1B0.40903755
134PRKD20.40048141
135AURKA0.39610773
136MAP2K10.39374088
137SCYL20.38352031
138CSNK1G20.38020558
139PIM20.37197822
140BMPR20.37187799
141FYN0.36543667
142RPS6KA60.36442336
143NEK60.36254581
144BRSK10.36003262
145ILK0.35252876
146DYRK1A0.34401583
147PRKCI0.34375969
148MAP3K60.34194919

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27844071
2Nicotine addiction_Homo sapiens_hsa050333.03541107
3Olfactory transduction_Homo sapiens_hsa047402.56259012
4Long-term potentiation_Homo sapiens_hsa047202.51008318
5GABAergic synapse_Homo sapiens_hsa047272.47634374
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45877227
7Circadian entrainment_Homo sapiens_hsa047132.35408072
8Amphetamine addiction_Homo sapiens_hsa050312.34091038
9Glutamatergic synapse_Homo sapiens_hsa047242.33961805
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27853085
11Morphine addiction_Homo sapiens_hsa050322.19534967
12Dopaminergic synapse_Homo sapiens_hsa047282.11717097
13Insulin secretion_Homo sapiens_hsa049112.06084382
14Salivary secretion_Homo sapiens_hsa049701.99071636
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98934171
16Other glycan degradation_Homo sapiens_hsa005111.93782030
17Cholinergic synapse_Homo sapiens_hsa047251.89407472
18Gastric acid secretion_Homo sapiens_hsa049711.87586074
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74658116
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73499014
21Vitamin B6 metabolism_Homo sapiens_hsa007501.71625222
22Cocaine addiction_Homo sapiens_hsa050301.68101439
23Sulfur relay system_Homo sapiens_hsa041221.65189063
24Renin secretion_Homo sapiens_hsa049241.61283420
25Oxytocin signaling pathway_Homo sapiens_hsa049211.60808217
26Taste transduction_Homo sapiens_hsa047421.58624098
27Long-term depression_Homo sapiens_hsa047301.57758378
28Ribosome_Homo sapiens_hsa030101.53208041
29GnRH signaling pathway_Homo sapiens_hsa049121.48911507
30Serotonergic synapse_Homo sapiens_hsa047261.48615727
31Acute myeloid leukemia_Homo sapiens_hsa052211.45772524
32Collecting duct acid secretion_Homo sapiens_hsa049661.44295766
33Notch signaling pathway_Homo sapiens_hsa043301.41141625
34B cell receptor signaling pathway_Homo sapiens_hsa046621.38149882
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37785001
36Calcium signaling pathway_Homo sapiens_hsa040201.36548474
37Bladder cancer_Homo sapiens_hsa052191.35209495
38Gap junction_Homo sapiens_hsa045401.32956841
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32526460
40Estrogen signaling pathway_Homo sapiens_hsa049151.28259067
41Type II diabetes mellitus_Homo sapiens_hsa049301.26094846
42Cardiac muscle contraction_Homo sapiens_hsa042601.26092066
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23629363
44Chronic myeloid leukemia_Homo sapiens_hsa052201.21601453
45Glioma_Homo sapiens_hsa052141.21281701
46Osteoclast differentiation_Homo sapiens_hsa043801.20473944
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19243289
48cAMP signaling pathway_Homo sapiens_hsa040241.16158955
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16023719
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15612804
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13203158
52Folate biosynthesis_Homo sapiens_hsa007901.11383146
53Melanogenesis_Homo sapiens_hsa049161.06769255
54Vibrio cholerae infection_Homo sapiens_hsa051101.06633073
55Dorso-ventral axis formation_Homo sapiens_hsa043201.05506770
56ErbB signaling pathway_Homo sapiens_hsa040121.04976319
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03180423
58Axon guidance_Homo sapiens_hsa043601.01399439
59Pentose phosphate pathway_Homo sapiens_hsa000301.00705999
60Galactose metabolism_Homo sapiens_hsa000520.95572110
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94142827
62Fructose and mannose metabolism_Homo sapiens_hsa000510.94087313
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.93839805
64Oocyte meiosis_Homo sapiens_hsa041140.92099126
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.91920736
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91762499
67VEGF signaling pathway_Homo sapiens_hsa043700.89044756
68Pancreatic secretion_Homo sapiens_hsa049720.88922392
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84607816
70Pancreatic cancer_Homo sapiens_hsa052120.84499113
71AMPK signaling pathway_Homo sapiens_hsa041520.84461609
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82550430
73Thyroid hormone synthesis_Homo sapiens_hsa049180.80687928
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.78622480
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78341938
76MAPK signaling pathway_Homo sapiens_hsa040100.76802613
77mTOR signaling pathway_Homo sapiens_hsa041500.74773725
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.74305441
79Choline metabolism in cancer_Homo sapiens_hsa052310.74292983
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73891641
81Dilated cardiomyopathy_Homo sapiens_hsa054140.73230985
82Glucagon signaling pathway_Homo sapiens_hsa049220.72974720
83Endocytosis_Homo sapiens_hsa041440.72285255
84Nitrogen metabolism_Homo sapiens_hsa009100.72018985
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.71769809
86Tuberculosis_Homo sapiens_hsa051520.70861276
87Alzheimers disease_Homo sapiens_hsa050100.70654338
88Lysosome_Homo sapiens_hsa041420.69505961
89Renal cell carcinoma_Homo sapiens_hsa052110.68997038
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68826795
91Thyroid cancer_Homo sapiens_hsa052160.67269274
92Insulin resistance_Homo sapiens_hsa049310.66781142
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.66669112
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66280133
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65664398
96Salmonella infection_Homo sapiens_hsa051320.64460316
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62767029
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61623435
99Ras signaling pathway_Homo sapiens_hsa040140.61299826
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60813923
101Rap1 signaling pathway_Homo sapiens_hsa040150.59136878
102Type I diabetes mellitus_Homo sapiens_hsa049400.58990030
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58912434
104Hepatitis B_Homo sapiens_hsa051610.57442413
105Hepatitis C_Homo sapiens_hsa051600.55026635
106Non-small cell lung cancer_Homo sapiens_hsa052230.54791793
107HIF-1 signaling pathway_Homo sapiens_hsa040660.54536265
108Oxidative phosphorylation_Homo sapiens_hsa001900.54341749
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54119599
110Alcoholism_Homo sapiens_hsa050340.51674924
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51462883
112T cell receptor signaling pathway_Homo sapiens_hsa046600.51045064
113Insulin signaling pathway_Homo sapiens_hsa049100.50938041
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49505344
115Parkinsons disease_Homo sapiens_hsa050120.49370283
116Prion diseases_Homo sapiens_hsa050200.48637294
117Inositol phosphate metabolism_Homo sapiens_hsa005620.48311981
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46536923
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45754986
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44756675
121Wnt signaling pathway_Homo sapiens_hsa043100.44570305
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43383241
123Endometrial cancer_Homo sapiens_hsa052130.41977038
124Phototransduction_Homo sapiens_hsa047440.41686819
125Bile secretion_Homo sapiens_hsa049760.39610430
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39243315
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38927537
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35739398
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34926883
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.34581311
131Hedgehog signaling pathway_Homo sapiens_hsa043400.34556009
132Chemokine signaling pathway_Homo sapiens_hsa040620.31859818
133Huntingtons disease_Homo sapiens_hsa050160.31754034
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31343350

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