MYRFL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)7.66596324
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.60634121
3vitamin A metabolic process (GO:0006776)6.86073094
4regulation of bile acid biosynthetic process (GO:0070857)6.67568086
5positive regulation of guanylate cyclase activity (GO:0031284)6.44422728
6virion attachment to host cell (GO:0019062)6.42126862
7adhesion of symbiont to host cell (GO:0044650)6.42126862
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.28485438
9actin filament depolymerization (GO:0030042)6.18976416
10digestive system process (GO:0022600)5.80492766
11modified amino acid transport (GO:0072337)5.46966528
12drug catabolic process (GO:0042737)5.34083364
13epoxygenase P450 pathway (GO:0019373)5.26284115
14UDP-N-acetylglucosamine metabolic process (GO:0006047)5.10474223
15flavonoid metabolic process (GO:0009812)5.09331489
16adhesion of symbiont to host (GO:0044406)5.05420296
17fat-soluble vitamin biosynthetic process (GO:0042362)4.92112076
18cellular glucuronidation (GO:0052695)4.82594117
19glucuronate metabolic process (GO:0019585)4.74053295
20uronic acid metabolic process (GO:0006063)4.74053295
21NADH metabolic process (GO:0006734)4.70618927
22intestinal epithelial cell development (GO:0060576)4.69677815
23response to hepatocyte growth factor (GO:0035728)4.69213605
24cellular response to hepatocyte growth factor stimulus (GO:0035729)4.69213605
25positive regulation of lipoprotein lipase activity (GO:0051006)4.69111210
26positive regulation of triglyceride lipase activity (GO:0061365)4.69111210
27positive regulation of glycoprotein biosynthetic process (GO:0010560)4.64918808
28regulation of cGMP biosynthetic process (GO:0030826)4.62709343
29glucose 6-phosphate metabolic process (GO:0051156)4.59497698
30plasma lipoprotein particle assembly (GO:0034377)4.59416543
31peptide hormone processing (GO:0016486)4.59115715
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59043895
33hormone catabolic process (GO:0042447)4.57643973
34lipoprotein metabolic process (GO:0042157)4.55841499
35regulation of cholesterol esterification (GO:0010872)4.48070988
36digestion (GO:0007586)4.43808992
37phospholipid efflux (GO:0033700)4.40845760
38regulation of triglyceride catabolic process (GO:0010896)4.38809801
39protein-lipid complex assembly (GO:0065005)4.36269987
40drinking behavior (GO:0042756)4.29748625
41purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.26278787
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.26278787
43peptide catabolic process (GO:0043171)4.18087203
44very-low-density lipoprotein particle assembly (GO:0034379)4.13031384
45drug metabolic process (GO:0017144)4.12766851
46positive regulation of respiratory burst (GO:0060267)4.07970205
47transepithelial transport (GO:0070633)4.04946159
48lipoprotein transport (GO:0042953)4.03843792
49cholesterol efflux (GO:0033344)4.03062796
50cholesterol homeostasis (GO:0042632)4.01266048
51diacylglycerol metabolic process (GO:0046339)4.00494612
52sulfate transmembrane transport (GO:1902358)3.98369841
53sterol homeostasis (GO:0055092)3.96043105
54antibacterial humoral response (GO:0019731)3.95468799
55disruption of cells of other organism (GO:0044364)3.92426448
56killing of cells of other organism (GO:0031640)3.92426448
57regulation of cGMP metabolic process (GO:0030823)3.90417961
58defense response to fungus (GO:0050832)3.90008163
59positive regulation of glycoprotein metabolic process (GO:1903020)3.87740558
60antimicrobial humoral response (GO:0019730)3.86900012
61ventricular cardiac muscle cell action potential (GO:0086005)3.82181189
62purine nucleotide salvage (GO:0032261)3.81558773
63cholesterol transport (GO:0030301)3.75669898
64sterol transport (GO:0015918)3.75669898
65sulfur compound transport (GO:0072348)3.73665475
66regulation of systemic arterial blood pressure by hormone (GO:0001990)3.72695379
67regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.72695379
68endocrine process (GO:0050886)3.72695379
69positive regulation of cGMP biosynthetic process (GO:0030828)3.71165091
70protein targeting to Golgi (GO:0000042)3.69362617
71vitamin transmembrane transport (GO:0035461)3.67061879
72establishment of protein localization to Golgi (GO:0072600)3.62694425
73regulation of cholesterol homeostasis (GO:2000188)3.62066216
74thyroid hormone metabolic process (GO:0042403)3.60307106
75bile acid and bile salt transport (GO:0015721)3.55658657
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.54222699
77sperm capacitation (GO:0048240)3.51398918
78bicarbonate transport (GO:0015701)3.45057065
79maintenance of gastrointestinal epithelium (GO:0030277)3.43045063
80sphingomyelin metabolic process (GO:0006684)3.43002552
81regulation of digestive system process (GO:0044058)3.41709517
82retrograde transport, vesicle recycling within Golgi (GO:0000301)3.40916804
83arginine metabolic process (GO:0006525)3.40710045
84alkaloid metabolic process (GO:0009820)3.40105242
85sperm motility (GO:0030317)3.39859263
86sulfate transport (GO:0008272)3.36708766
87innate immune response in mucosa (GO:0002227)3.36193487
88proline transport (GO:0015824)3.35109677
89negative regulation of cholesterol transport (GO:0032375)3.34804149
90negative regulation of sterol transport (GO:0032372)3.34804149
91cobalamin metabolic process (GO:0009235)3.33961142
92receptor guanylyl cyclase signaling pathway (GO:0007168)3.33285814
93cellular carbohydrate catabolic process (GO:0044275)3.31722730
94polyol transport (GO:0015791)3.31325967
95oligosaccharide catabolic process (GO:0009313)3.30775735
96regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.29670054
97auditory receptor cell differentiation (GO:0042491)3.26822505
98negative regulation of digestive system process (GO:0060457)3.23166844
99regulation of protein glycosylation (GO:0060049)3.22320661
100heme transport (GO:0015886)3.20829564
101regulation of systemic arterial blood pressure (GO:0003073)3.20453332
102endocrine pancreas development (GO:0031018)3.20040823
103fat-soluble vitamin metabolic process (GO:0006775)3.19921487
104regulation of actin nucleation (GO:0051125)3.19359712
105membrane repolarization during action potential (GO:0086011)3.16942403
106positive regulation of cGMP metabolic process (GO:0030825)3.15436444
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15103186
108trophectodermal cell differentiation (GO:0001829)3.14756359
109cellular ketone body metabolic process (GO:0046950)3.12893587
110sulfation (GO:0051923)3.12142279
111fusion of sperm to egg plasma membrane (GO:0007342)3.10671657
112sexual reproduction (GO:0019953)3.10569434
113regulation of viral release from host cell (GO:1902186)3.07258461
114positive regulation of fatty acid biosynthetic process (GO:0045723)3.07177065
115drug transmembrane transport (GO:0006855)3.06754919
116O-glycan processing (GO:0016266)3.05438427
117transcytosis (GO:0045056)3.04782955
118positive regulation of glycolytic process (GO:0045821)3.03059155
119negative regulation of keratinocyte proliferation (GO:0010839)3.01064045
120fructose metabolic process (GO:0006000)3.00863087
121vitamin biosynthetic process (GO:0009110)3.00785980
122glycerol metabolic process (GO:0006071)2.99109754
123renal system process involved in regulation of blood volume (GO:0001977)2.98299541
124glycolipid catabolic process (GO:0019377)2.97760130
125bile acid metabolic process (GO:0008206)2.97650388
126urea cycle (GO:0000050)2.96864132
127urea metabolic process (GO:0019627)2.96864132
128glycosphingolipid catabolic process (GO:0046479)2.95407974
129phenylpropanoid metabolic process (GO:0009698)2.95307128
130response to hydroperoxide (GO:0033194)2.94813834
131protein localization to Golgi apparatus (GO:0034067)2.94656755
132desmosome organization (GO:0002934)2.94211881
133acrosome reaction (GO:0007340)2.92885887
134vitamin transport (GO:0051180)2.92340435
135drug transport (GO:0015893)2.90822156
136kidney morphogenesis (GO:0060993)2.90476589
137striated muscle atrophy (GO:0014891)2.90358168
138regulation of cellular extravasation (GO:0002691)2.88911560
139alditol metabolic process (GO:0019400)2.88677835
140nonribosomal peptide biosynthetic process (GO:0019184)2.87718386
141calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87504558
142cellular response to nitric oxide (GO:0071732)2.87320927
143homocysteine metabolic process (GO:0050667)2.87097363
144ceramide catabolic process (GO:0046514)2.85923443
145glycosylceramide metabolic process (GO:0006677)2.82929855
146coenzyme catabolic process (GO:0009109)2.78938111
147carnitine transport (GO:0015879)2.77795650
148amino-acid betaine transport (GO:0015838)2.77795650
149phenol-containing compound catabolic process (GO:0019336)2.77616636
150sphingolipid catabolic process (GO:0030149)2.77500254
151mRNA modification (GO:0016556)2.72780919
152negative regulation of gene silencing (GO:0060969)2.72458787
153lactate metabolic process (GO:0006089)2.72215494
154intestinal absorption (GO:0050892)13.1604027
155intestinal cholesterol absorption (GO:0030299)12.4035869
156angiotensin maturation (GO:0002003)11.7239410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.09113448
2SOX2_27498859_Chip-Seq_STOMACH_Mouse4.12206346
3HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.70119246
4GATA4_25053715_ChIP-Seq_YYC3_Human3.48729536
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35708104
6GATA6_25053715_ChIP-Seq_YYC3_Human3.25831147
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97335502
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76354869
9SOX2_20726797_ChIP-Seq_SW620_Human2.62597783
10AR_21909140_ChIP-Seq_LNCAP_Human2.56901778
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53219149
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.49869838
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35906734
14GATA1_22025678_ChIP-Seq_K562_Human2.31772199
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.28344940
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.20241686
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.12487583
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.08649738
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05009718
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01572131
21TP63_17297297_ChIP-ChIP_HaCaT_Human10.5019488
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97977840
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97675972
24FUS_26573619_Chip-Seq_HEK293_Human1.95534816
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.94951883
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90178292
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87815693
28P300_19829295_ChIP-Seq_ESCs_Human1.83968380
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.83370690
30BCAT_22108803_ChIP-Seq_LS180_Human1.81715381
31KLF5_25053715_ChIP-Seq_YYC3_Human1.81358659
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.78838616
33VDR_22108803_ChIP-Seq_LS180_Human1.75377543
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.75229511
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74733248
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69092987
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67096136
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66710982
39CBP_20019798_ChIP-Seq_JUKART_Human1.66710982
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.62873651
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60521918
42TCF4_22108803_ChIP-Seq_LS180_Human1.58780633
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.58336863
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58235267
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58206432
46ATF3_27146783_Chip-Seq_COLON_Human1.57540598
47AR_25329375_ChIP-Seq_VCAP_Human1.57382053
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55867585
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.55092007
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.55092007
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53974302
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53652246
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.53239616
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.53118144
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51426740
56ZNF263_19887448_ChIP-Seq_K562_Human1.50292043
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48431842
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.48297868
59TAF15_26573619_Chip-Seq_HEK293_Human1.47799691
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47119183
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.47087176
62ER_23166858_ChIP-Seq_MCF-7_Human1.46462667
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.44709503
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44107888
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43553783
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42568196
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41289133
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40158040
69RACK7_27058665_Chip-Seq_MCF-7_Human1.39621048
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37670940
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36900765
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.35857663
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35475182
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35260296
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.34841948
76NANOG_19829295_ChIP-Seq_ESCs_Human1.34543847
77SOX2_19829295_ChIP-Seq_ESCs_Human1.34543847
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.34485769
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33475244
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.32863966
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31461695
82AHR_22903824_ChIP-Seq_MCF-7_Human1.30699245
83RBPJ_21746931_ChIP-Seq_IB4_Human1.30320314
84PHF8_20622853_ChIP-Seq_HELA_Human1.29211436
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27990949
86ZNF274_21170338_ChIP-Seq_K562_Hela1.27811439
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26290025
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25918820
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25502820
90ETV1_20927104_ChIP-Seq_GIST48_Human1.24784044
91CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24639911
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24425539
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24216061
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24092790
95TBL1_22424771_ChIP-Seq_293T_Human1.22634201
96NFYB_21822215_ChIP-Seq_K562_Human1.22178354
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21880091
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21713075
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21500380
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21500380
101TAF2_19829295_ChIP-Seq_ESCs_Human1.21035155
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20748808
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20398148
104ERG_20517297_ChIP-Seq_VCAP_Human1.20337476
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20282622
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20082293
107CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19956737
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19595191
109GATA2_19941826_ChIP-Seq_K562_Human1.19175481
110STAT3_23295773_ChIP-Seq_U87_Human1.18334069
111IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17647254
112TP63_23658742_ChIP-Seq_EP156T_Human1.17536956
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17511249
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17436058
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17405818
116NFYA_21822215_ChIP-Seq_K562_Human1.17232745
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15479474
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14172362
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13592223
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12413021
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12037859
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.11386320
123CBP_21632823_ChIP-Seq_H3396_Human1.11152792
124NCOR_22424771_ChIP-Seq_293T_Human1.10599021
125SMAD4_21799915_ChIP-Seq_A2780_Human1.09024889
126ESR1_21235772_ChIP-Seq_MCF-7_Human1.08617128
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.08373312
128CEBPB_22108803_ChIP-Seq_LS180_Human1.07825486
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07459938
130AR_20517297_ChIP-Seq_VCAP_Human1.06734747
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.05070323
132MYC_19829295_ChIP-Seq_ESCs_Human1.03909572
133TP53_16413492_ChIP-PET_HCT116_Human1.03587046
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.02734560
135KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02212900
136SALL1_21062744_ChIP-ChIP_HESCs_Human1.02162025
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00752222
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.98241150
139TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97812118
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95496483
141NANOG_20526341_ChIP-Seq_ESCs_Human0.95124516
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94979023
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94676610
144TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94470898
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94097297
146STAT1_17558387_ChIP-Seq_HELA_Human0.93916782
147CREB1_26743006_Chip-Seq_LNCaP_Human0.93245616
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93038057
149CLOCK_20551151_ChIP-Seq_293T_Human0.91399417
150EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90919867
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89898247
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88720195
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87513950
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87513950
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86206925
156PHF8_20622854_ChIP-Seq_HELA_Human0.85068229
157CDX2_22108803_ChIP-Seq_LS180_Human0.83670009
158SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77943496
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.77709926
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77139919
161SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77112853
162KAP1_27257070_Chip-Seq_ESCs_Mouse0.75706980
163NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74548439
164FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74364722
165NANOG_18692474_ChIP-Seq_MESCs_Mouse0.73778620
166EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73251004
167EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73243521
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73142984
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.73070577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.63978662
2MP0001666_abnormal_nutrient_absorption5.90699888
3MP0009840_abnormal_foam_cell4.82633704
4MP0004264_abnormal_extraembryonic_tissu3.98550923
5MP0000462_abnormal_digestive_system3.72232994
6MP0010234_abnormal_vibrissa_follicle3.57532792
7MP0003195_calcinosis3.48035217
8MP0005085_abnormal_gallbladder_physiolo3.42219354
9MP0003183_abnormal_peptide_metabolism3.26647458
10MP0002139_abnormal_hepatobiliary_system3.19806665
11MP0003283_abnormal_digestive_organ2.99726691
12MP0003252_abnormal_bile_duct2.90172175
13MP0003866_abnormal_defecation2.56261669
14MP0008875_abnormal_xenobiotic_pharmacok2.45753053
15MP0005410_abnormal_fertilization2.43703202
16MP0010329_abnormal_lipoprotein_level2.39059332
17MP0004147_increased_porphyrin_level2.32041919
18MP0004019_abnormal_vitamin_homeostasis2.23457933
19MP0000537_abnormal_urethra_morphology2.10920500
20MP0009379_abnormal_foot_pigmentation2.09759340
21MP0005670_abnormal_white_adipose2.05757449
22MP0005377_hearing/vestibular/ear_phenot1.96708041
23MP0003878_abnormal_ear_physiology1.96708041
24MP0005365_abnormal_bile_salt1.94452652
25MP0001873_stomach_inflammation1.84643512
26MP0002822_catalepsy1.82875734
27MP0003300_gastrointestinal_ulcer1.80484524
28MP0010352_gastrointestinal_tract_polyps1.76429977
29MP0005084_abnormal_gallbladder_morpholo1.74491176
30MP0005381_digestive/alimentary_phenotyp1.74434403
31MP0001663_abnormal_digestive_system1.65474381
32MP0001664_abnormal_digestion1.65230266
33MP0000490_abnormal_crypts_of1.62833341
34MP0000538_abnormal_urinary_bladder1.58370100
35MP0010155_abnormal_intestine_physiology1.57134726
36MP0000477_abnormal_intestine_morphology1.54190323
37MP0003868_abnormal_feces_composition1.50053875
38MP0009697_abnormal_copulation1.48741435
39MP0003693_abnormal_embryo_hatching1.45274534
40MP0001501_abnormal_sleep_pattern1.43935544
41MP0003718_maternal_effect1.41283245
42MP0004043_abnormal_pH_regulation1.39517310
43MP0003806_abnormal_nucleotide_metabolis1.35682279
44MP0002102_abnormal_ear_morphology1.32436950
45MP0003705_abnormal_hypodermis_morpholog1.32077958
46MP0005448_abnormal_energy_balance1.30279111
47MP0003950_abnormal_plasma_membrane1.27680214
48MP0002089_abnormal_postnatal_growth/wei1.25984011
49MP0002796_impaired_skin_barrier1.13693285
50MP0008004_abnormal_stomach_pH1.12303124
51MP0005409_darkened_coat_color1.09369562
52MP0003191_abnormal_cellular_cholesterol1.08654285
53MP0000383_abnormal_hair_follicle1.08396127
54MP0008775_abnormal_heart_ventricle1.06772251
55MP0002254_reproductive_system_inflammat1.06575584
56MP0009643_abnormal_urine_homeostasis1.06170689
57MP0005332_abnormal_amino_acid1.05472519
58MP0002234_abnormal_pharynx_morphology1.03528877
59MP0005535_abnormal_body_temperature1.03488776
60MP0001849_ear_inflammation0.97870319
61MP0004782_abnormal_surfactant_physiolog0.95442580
62MP0003011_delayed_dark_adaptation0.94539722
63MP0001756_abnormal_urination0.91922680
64MP0003787_abnormal_imprinting0.90967278
65MP0005379_endocrine/exocrine_gland_phen0.89709072
66MP0003698_abnormal_male_reproductive0.89250706
67MP0008872_abnormal_physiological_respon0.88668707
68MP0005645_abnormal_hypothalamus_physiol0.88412645
69MP0005451_abnormal_body_composition0.87402114
70MP0008877_abnormal_DNA_methylation0.85617129
71MP0003879_abnormal_hair_cell0.83465936
72MP0006054_spinal_hemorrhage0.82370329
73MP0002118_abnormal_lipid_homeostasis0.81038639
74MP0005395_other_phenotype0.80825529
75MP0005174_abnormal_tail_pigmentation0.80215555
76MP0002909_abnormal_adrenal_gland0.79902451
77MP0002098_abnormal_vibrissa_morphology0.79765687
78MP0005551_abnormal_eye_electrophysiolog0.79481874
79MP0003119_abnormal_digestive_system0.78643401
80MP0003315_abnormal_perineum_morphology0.78408075
81MP0002078_abnormal_glucose_homeostasis0.77190806
82MP0005266_abnormal_metabolism0.77009020
83MP0010678_abnormal_skin_adnexa0.76294732
84MP0001764_abnormal_homeostasis0.74662133
85MP0003953_abnormal_hormone_level0.74566157
86MP0009053_abnormal_anal_canal0.73987957
87MP0001485_abnormal_pinna_reflex0.73642620
88MP0004270_analgesia0.73618975
89MP0000609_abnormal_liver_physiology0.73197186
90MP0000613_abnormal_salivary_gland0.72302627
91MP0001929_abnormal_gametogenesis0.71378929
92MP0002163_abnormal_gland_morphology0.68429459
93MP0004085_abnormal_heartbeat0.67620225
94MP0000427_abnormal_hair_cycle0.67404745
95MP0000230_abnormal_systemic_arterial0.67149383
96MP0005167_abnormal_blood-brain_barrier0.66973737
97MP0004947_skin_inflammation0.66954277
98MP0001765_abnormal_ion_homeostasis0.64999470
99MP0006138_congestive_heart_failure0.64857869
100MP0002127_abnormal_cardiovascular_syste0.64194508
101MP0002876_abnormal_thyroid_physiology0.63789994
102MP0009384_cardiac_valve_regurgitation0.63739190
103MP0000516_abnormal_urinary_system0.63109585
104MP0005367_renal/urinary_system_phenotyp0.63109585
105MP0005319_abnormal_enzyme/_coenzyme0.63072438
106MP0005501_abnormal_skin_physiology0.62869649
107MP0002138_abnormal_hepatobiliary_system0.62377645
108MP0000467_abnormal_esophagus_morphology0.62364506
109MP0004484_altered_response_of0.61810055
110MP0009780_abnormal_chondrocyte_physiolo0.61516919
111MP0003938_abnormal_ear_development0.61000763
112MP0003453_abnormal_keratinocyte_physiol0.60063307
113MP0002693_abnormal_pancreas_physiology0.59310769
114MP0005636_abnormal_mineral_homeostasis0.59118196
115MP0002277_abnormal_respiratory_mucosa0.58751810
116MP0004957_abnormal_blastocyst_morpholog0.58596961
117MP0001216_abnormal_epidermal_layer0.56510600
118MP0002069_abnormal_eating/drinking_beha0.55115262
119MP0002136_abnormal_kidney_physiology0.54923355
120MP0001293_anophthalmia0.54883678
121MP0001730_embryonic_growth_arrest0.54819460
122MP0003123_paternal_imprinting0.54370396
123MP0000013_abnormal_adipose_tissue0.53654160
124MP0001440_abnormal_grooming_behavior0.53212584
125MP0002160_abnormal_reproductive_system0.53180215
126MP0002090_abnormal_vision0.52308478
127MP0005166_decreased_susceptibility_to0.51476923
128MP0002837_dystrophic_cardiac_calcinosis0.51436070
129MP0000678_abnormal_parathyroid_gland0.50299440
130MP0000566_synostosis0.49388521
131MP0005408_hypopigmentation0.46566778
132MP0005376_homeostasis/metabolism_phenot0.45434491
133MP0005310_abnormal_salivary_gland0.44883190
134MP0001188_hyperpigmentation0.43776946
135MP0010307_abnormal_tumor_latency0.43595412
136MP0004215_abnormal_myocardial_fiber0.39599657
137MP0000470_abnormal_stomach_morphology0.39460213
138MP0000377_abnormal_hair_follicle0.39337300
139MP0000015_abnormal_ear_pigmentation0.38395571
140MP0009642_abnormal_blood_homeostasis0.37347250
141MP0003828_pulmonary_edema0.37029082

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.93083470
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.80645758
3Hypobetalipoproteinemia (HP:0003563)6.48114671
4Acanthocytosis (HP:0001927)6.45001687
5Right ventricular cardiomyopathy (HP:0011663)5.80360550
6Malnutrition (HP:0004395)5.72251420
7Conjugated hyperbilirubinemia (HP:0002908)5.07114536
8Hydroxyprolinuria (HP:0003080)4.71265926
9Abnormality of proline metabolism (HP:0010907)4.71265926
10Autoimmune thrombocytopenia (HP:0001973)4.67350686
11Widely patent fontanelles and sutures (HP:0004492)4.47528981
12Pigmentary retinal degeneration (HP:0001146)4.25822758
13Ventricular fibrillation (HP:0001663)4.13951559
14Fat malabsorption (HP:0002630)3.97731714
15Poikilocytosis (HP:0004447)3.75309952
16Hyperglycinuria (HP:0003108)3.74773678
17Chronic diarrhea (HP:0002028)3.68792628
18Cupped ribs (HP:0000887)3.64142485
19Autoimmune hemolytic anemia (HP:0001890)3.63470415
20Abnormality of the vitamin B12 metabolism (HP:0004341)3.59904804
21Hyperinsulinemic hypoglycemia (HP:0000825)3.47450380
22Congenital sensorineural hearing impairment (HP:0008527)3.47241778
23Hypolipoproteinemia (HP:0010981)3.45362373
24Glycosuria (HP:0003076)3.43984086
25Abnormality of urine glucose concentration (HP:0011016)3.43984086
26Wide cranial sutures (HP:0010537)3.36414447
27Rectal prolapse (HP:0002035)3.35998688
28Abnormality of vitamin B metabolism (HP:0004340)3.32620160
29Hyperphosphatemia (HP:0002905)3.24292839
30Gastrointestinal dysmotility (HP:0002579)3.23313406
31Syncope (HP:0001279)3.19756113
32Abdominal distention (HP:0003270)3.15927449
33Abnormal biliary tract morphology (HP:0012440)3.05198554
34Abnormal glucose tolerance (HP:0001952)3.03543654
35Metabolic alkalosis (HP:0200114)2.92548921
36Bundle branch block (HP:0011710)2.92480671
37Abnormality of renin-angiotensin system (HP:0000847)2.84148532
38Mesangial abnormality (HP:0001966)2.80657800
39Decreased circulating renin level (HP:0003351)2.76863647
40Palpitations (HP:0001962)2.76371757
41Pustule (HP:0200039)2.75654851
42Increased purine levels (HP:0004368)2.75203137
43Hyperuricemia (HP:0002149)2.75203137
44Dehydration (HP:0001944)2.73404362
45Abnormality of vitamin metabolism (HP:0100508)2.72228288
46Thin bony cortex (HP:0002753)2.66821730
47Hypothermia (HP:0002045)2.66507340
48Potter facies (HP:0002009)2.66052508
49Facial shape deformation (HP:0011334)2.66052508
50Increased mean platelet volume (HP:0011877)2.65991498
51Abnormality of serine family amino acid metabolism (HP:0010894)2.63958133
52Abnormality of glycine metabolism (HP:0010895)2.63958133
53Hypoglycemic coma (HP:0001325)2.62862416
54Nephrolithiasis (HP:0000787)2.61102739
55Confusion (HP:0001289)2.60422914
56Progressive sensorineural hearing impairment (HP:0000408)2.60416413
57Mildly elevated creatine phosphokinase (HP:0008180)2.58087470
58Male infertility (HP:0003251)2.56787511
59Abnormality of small intestinal villus morphology (HP:0011472)2.56465416
60Villous atrophy (HP:0011473)2.56465416
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52241094
62Hyperactive renin-angiotensin system (HP:0000841)2.51972936
63Symptomatic seizures (HP:0011145)2.48914795
64Hypoglycemic seizures (HP:0002173)2.48691815
65Progressive hearing impairment (HP:0001730)2.48644293
66Pili torti (HP:0003777)2.47404008
67Hypophosphatemia (HP:0002148)2.42716418
68Late onset (HP:0003584)2.41196636
69Ketoacidosis (HP:0001993)2.40619226
70Increased circulating renin level (HP:0000848)2.36195948
71Abnormal pancreas size (HP:0012094)2.35912791
72Ventricular tachycardia (HP:0004756)2.34884119
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34018786
74Megaloblastic anemia (HP:0001889)2.32579061
75Increased IgE level (HP:0003212)2.28852122
76Hypotension (HP:0002615)2.28187199
77Abnormality of magnesium homeostasis (HP:0004921)2.28088971
78Generalized aminoaciduria (HP:0002909)2.27753410
79Ventricular arrhythmia (HP:0004308)2.27223836
80Abnormality of the gastric mucosa (HP:0004295)2.27045370
81Woolly hair (HP:0002224)2.26970176
82Alkalosis (HP:0001948)2.26081886
83Focal segmental glomerulosclerosis (HP:0000097)2.24004813
84Reticulocytosis (HP:0001923)2.24002014
85B lymphocytopenia (HP:0010976)2.23944806
86Abnormality of B cell number (HP:0010975)2.23944806
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23899892
88Nausea (HP:0002018)2.23881904
89Hypercholesterolemia (HP:0003124)2.23414637
90Dicarboxylic aciduria (HP:0003215)2.23033862
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23033862
92Hypophosphatemic rickets (HP:0004912)2.21033314
93Abnormal platelet volume (HP:0011876)2.20522706
94Delayed epiphyseal ossification (HP:0002663)2.18575005
95Intrahepatic cholestasis (HP:0001406)2.18409246
96Abnormality of purine metabolism (HP:0004352)2.17641446
97Sensory axonal neuropathy (HP:0003390)2.15393867
98Enlarged epiphyses (HP:0010580)2.15340391
99Gout (HP:0001997)2.14574302
100Abnormality of renal excretion (HP:0011036)2.13990820
101Severe combined immunodeficiency (HP:0004430)2.12278277
102Posterior subcapsular cataract (HP:0007787)2.12021340
103Urethral obstruction (HP:0000796)2.09578110
104Cheilitis (HP:0100825)2.09095154
105Congenital malformation of the right heart (HP:0011723)2.08974854
106Double outlet right ventricle (HP:0001719)2.08974854
107Steatorrhea (HP:0002570)2.08161011
108Abnormality of sulfur amino acid metabolism (HP:0004339)2.07043894
109Protuberant abdomen (HP:0001538)2.06927996
110Proximal tubulopathy (HP:0000114)2.05630484
111Milia (HP:0001056)2.05551940
112Breast hypoplasia (HP:0003187)2.01263133
113Combined immunodeficiency (HP:0005387)2.01009174
114Hyperphosphaturia (HP:0003109)1.99819659
115Myopathic facies (HP:0002058)1.99746148
116Lethargy (HP:0001254)1.98999727
117Xanthomatosis (HP:0000991)1.98239384
118Tongue fasciculations (HP:0001308)1.97600578
119Hyperglycemia (HP:0003074)1.97038152
120Fragile skin (HP:0001030)1.96852161
121Ketosis (HP:0001946)1.95222232
122Hypokalemia (HP:0002900)1.93860682
123Abnormal urine phosphate concentration (HP:0012599)1.93719402
124Tetany (HP:0001281)1.92896634
125Subcapsular cataract (HP:0000523)1.92172106
126Prolonged QT interval (HP:0001657)1.91952590
127Severe visual impairment (HP:0001141)1.91944544
128Abnormality of the costochondral junction (HP:0000919)1.91393122
129Methylmalonic aciduria (HP:0012120)1.91268016
130Abnormality of potassium homeostasis (HP:0011042)1.90428209
131Biliary tract neoplasm (HP:0100574)1.90299864
132Glomerulosclerosis (HP:0000096)1.89264185
133Hyperammonemia (HP:0001987)1.88000321
134Abnormality of endocrine pancreas physiology (HP:0012093)1.87137533
135Abnormality of the pancreatic islet cells (HP:0006476)1.87137533
136Metabolic acidosis (HP:0001942)1.87028625
137Muscle fibrillation (HP:0010546)1.86501962
138Polycythemia (HP:0001901)1.84854290
139Chronic hepatic failure (HP:0100626)1.82309669
140Micronodular cirrhosis (HP:0001413)1.81674826
141Alopecia of scalp (HP:0002293)1.81303279
142Insulin-resistant diabetes mellitus (HP:0000831)1.81079617
143Abnormal albumin level (HP:0012116)1.77564250
144Hypoalbuminemia (HP:0003073)1.77564250
145Abnormal urine output (HP:0012590)1.77520189
146Epidermoid cyst (HP:0200040)1.73027827
147Flat acetabular roof (HP:0003180)1.72922361
148Curly hair (HP:0002212)1.72392891
149Abnormality of nucleobase metabolism (HP:0010932)1.72267908
150Goiter (HP:0000853)1.71690446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.00011909
2FRK5.72480548
3MST45.22395379
4TNIK4.82394720
5MST1R3.67527125
6PRKG23.39149874
7AKT33.27544382
8NME13.14496135
9EPHA22.83408045
10NUAK12.78391189
11GRK62.60507801
12PLK42.43066446
13EIF2AK12.26840165
14MAP2K22.21790043
15BMPR1B2.16935480
16FGFR22.03972900
17TRIM282.00098612
18RIPK11.95642413
19CASK1.92074146
20MAP3K101.88630103
21TTK1.87013561
22INSRR1.84600392
23MAP2K61.80255917
24PTK61.77961591
25PDK21.73703054
26EPHB21.48738963
27FGFR31.38064928
28MAP3K21.35747319
29STK241.34691045
30PDK31.32457857
31PDK41.32457857
32PBK1.29396294
33STK391.27424929
34STK101.16298042
35MAP3K81.15054560
36LATS11.05962898
37IRAK11.05525489
38MAP3K111.02758592
39MET1.00031029
40EPHA40.98333847
41TESK10.95463787
42PRKCI0.93731220
43TAOK30.91990774
44IRAK30.89708088
45AURKB0.89681282
46MAP3K90.85313994
47PIK3CA0.83648566
48DYRK30.81717973
49ERBB20.78951430
50DAPK20.77312602
51PRKCE0.76857343
52MAP3K40.75315545
53PRKAA20.73317357
54PLK20.72971912
55EPHA30.71331589
56PTK20.70964469
57EPHB10.69801315
58EIF2AK30.66683629
59MYLK0.65550987
60TAF10.64512935
61ADRBK20.62631474
62WNK30.62116359
63STK30.61641000
64NEK10.60793214
65DDR20.59207981
66PHKG10.58063846
67PHKG20.58063846
68NTRK30.57619238
69BUB10.57446616
70PRKAA10.57186854
71TESK20.56843269
72PTK2B0.56261715
73MAPK110.56191085
74TSSK60.55622807
75PRKCZ0.53618647
76TAOK10.53329231
77TIE10.53135950
78RIPK40.52600899
79PAK40.52051836
80MAP2K10.51709855
81MAP4K20.49679250
82FER0.49548347
83NEK20.49333200
84ERN10.48007731
85PASK0.46436757
86KSR20.45905228
87BCR0.45548093
88PAK30.45099020
89STK38L0.41793776
90MKNK20.41287964
91ZAK0.39664952
92BMX0.39539842
93TLK10.39429121
94PDPK10.38938622
95GRK10.38554882
96MAP4K10.37131178
97CSNK1G10.36741577
98WNK40.35729449
99NEK60.35388736
100FGFR40.34351629
101PAK10.34332820
102PRKG10.34050934
103CSNK1A10.33548775
104MAP3K10.33070396
105OXSR10.32705354
106PLK30.32635278
107AKT20.32045831
108MAP3K70.31442987
109CHUK0.31205626
110MAP3K30.31199785
111MATK0.31019622
112MAP2K70.30400633
113LATS20.29932635
114CDK120.29916228
115STK110.29621338
116CSNK1E0.28352218
117MELK0.28228169
118CSNK1G30.28037740
119PLK10.25655811
120NLK0.25145596
121WEE10.25063073
122ALK0.24604045
123ACVR1B0.24488202
124MAPKAPK30.24112245
125PRKACA0.24040536
126CAMK2D0.23793090
127SCYL20.23599736
128CDK40.23502913
129CAMK2A0.23089800
130PRKCA0.22767198
131ROCK10.22441666
132PRKCG0.21415806
133PNCK0.21268824
134LIMK10.21102722
135DMPK0.20756566
136CHEK20.19877892
137BRSK20.19199351
138PDK10.18724873
139STK40.17706100
140JAK10.17151755
141PRKACG0.16397630
142PRKCD0.15583359
143MUSK0.15479884
144ERBB40.14549922
145MAPKAPK20.14393768
146MAP3K120.14332822
147CAMK2G0.14190534
148PRKCQ0.13951359

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.03190592
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.15381784
3Renin-angiotensin system_Homo sapiens_hsa046144.87933497
4Vitamin digestion and absorption_Homo sapiens_hsa049774.21439607
5Mineral absorption_Homo sapiens_hsa049784.13266031
6Galactose metabolism_Homo sapiens_hsa000522.92445664
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.78948638
8Caffeine metabolism_Homo sapiens_hsa002322.66490316
9Protein digestion and absorption_Homo sapiens_hsa049742.40756052
10Starch and sucrose metabolism_Homo sapiens_hsa005002.39741243
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.32703266
12Fructose and mannose metabolism_Homo sapiens_hsa000512.23170826
13Folate biosynthesis_Homo sapiens_hsa007902.21438480
14Bile secretion_Homo sapiens_hsa049762.10068841
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06678866
16Histidine metabolism_Homo sapiens_hsa003401.91436928
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78693238
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.63858199
19Sulfur metabolism_Homo sapiens_hsa009201.58599852
20Glutathione metabolism_Homo sapiens_hsa004801.56461715
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51096394
22Nitrogen metabolism_Homo sapiens_hsa009101.50719910
23Arginine and proline metabolism_Homo sapiens_hsa003301.44236393
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41421277
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.36342753
26Glycerolipid metabolism_Homo sapiens_hsa005611.34866145
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34783780
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33158745
29Tryptophan metabolism_Homo sapiens_hsa003801.28011685
30Sphingolipid metabolism_Homo sapiens_hsa006001.27311557
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19909584
32Arginine biosynthesis_Homo sapiens_hsa002201.14846338
33Fatty acid degradation_Homo sapiens_hsa000711.14319702
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11292338
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10902513
36PPAR signaling pathway_Homo sapiens_hsa033201.07074530
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06341506
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04767646
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04229787
40Propanoate metabolism_Homo sapiens_hsa006400.99352591
41Pentose phosphate pathway_Homo sapiens_hsa000300.98092325
42Tight junction_Homo sapiens_hsa045300.88841483
43Carbon metabolism_Homo sapiens_hsa012000.87499564
44Phenylalanine metabolism_Homo sapiens_hsa003600.84364275
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83680809
46beta-Alanine metabolism_Homo sapiens_hsa004100.83460665
47Thyroid hormone synthesis_Homo sapiens_hsa049180.78985688
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.78778859
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78571524
50Pyruvate metabolism_Homo sapiens_hsa006200.76672680
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.75140101
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.74482364
53ABC transporters_Homo sapiens_hsa020100.66710068
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60269840
55Biosynthesis of amino acids_Homo sapiens_hsa012300.55364433
56Regulation of autophagy_Homo sapiens_hsa041400.54913990
57Type I diabetes mellitus_Homo sapiens_hsa049400.53225922
58Pancreatic secretion_Homo sapiens_hsa049720.53188253
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53027014
60Retinol metabolism_Homo sapiens_hsa008300.50827309
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44893715
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.43718993
63Arachidonic acid metabolism_Homo sapiens_hsa005900.43413314
64Gastric acid secretion_Homo sapiens_hsa049710.41695941
65Fatty acid elongation_Homo sapiens_hsa000620.40997419
66N-Glycan biosynthesis_Homo sapiens_hsa005100.39648085
67Linoleic acid metabolism_Homo sapiens_hsa005910.38938238
68Insulin resistance_Homo sapiens_hsa049310.38672424
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.36231021
70Tyrosine metabolism_Homo sapiens_hsa003500.35176024
71Vitamin B6 metabolism_Homo sapiens_hsa007500.33470537
72Selenocompound metabolism_Homo sapiens_hsa004500.32593315
73Metabolic pathways_Homo sapiens_hsa011000.32452524
74Chemical carcinogenesis_Homo sapiens_hsa052040.32370303
75Steroid biosynthesis_Homo sapiens_hsa001000.31789279
76Cocaine addiction_Homo sapiens_hsa050300.31573900
77Adherens junction_Homo sapiens_hsa045200.30874547
78Salmonella infection_Homo sapiens_hsa051320.29276656
79Serotonergic synapse_Homo sapiens_hsa047260.28151161
80Type II diabetes mellitus_Homo sapiens_hsa049300.27134626
81Phototransduction_Homo sapiens_hsa047440.26541156
82Amphetamine addiction_Homo sapiens_hsa050310.25794784
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25435429
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25202612
85African trypanosomiasis_Homo sapiens_hsa051430.25132365
86Lysine degradation_Homo sapiens_hsa003100.24485900
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24130347
88Hepatitis C_Homo sapiens_hsa051600.24038775
89Purine metabolism_Homo sapiens_hsa002300.23847644
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22285314
91Olfactory transduction_Homo sapiens_hsa047400.22238464
92GnRH signaling pathway_Homo sapiens_hsa049120.20032330
93Protein export_Homo sapiens_hsa030600.19601616
94Collecting duct acid secretion_Homo sapiens_hsa049660.19303451
95Fatty acid metabolism_Homo sapiens_hsa012120.19188632
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18993627
97Glucagon signaling pathway_Homo sapiens_hsa049220.18502093
98Taste transduction_Homo sapiens_hsa047420.18209225
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17620786
100Thyroid cancer_Homo sapiens_hsa052160.14770435
101Salivary secretion_Homo sapiens_hsa049700.14603658
102Fatty acid biosynthesis_Homo sapiens_hsa000610.13702788
103Ovarian steroidogenesis_Homo sapiens_hsa049130.13401287
104Butanoate metabolism_Homo sapiens_hsa006500.12224586
105Ether lipid metabolism_Homo sapiens_hsa005650.11939215
106Inositol phosphate metabolism_Homo sapiens_hsa005620.11495117
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10015482
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.09979305
109Insulin secretion_Homo sapiens_hsa049110.09695505
110AMPK signaling pathway_Homo sapiens_hsa041520.08369418
111Other glycan degradation_Homo sapiens_hsa005110.07429181
112Vibrio cholerae infection_Homo sapiens_hsa051100.07309941
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06948779
114Bladder cancer_Homo sapiens_hsa052190.06119934
115Hematopoietic cell lineage_Homo sapiens_hsa046400.05037215
116Asthma_Homo sapiens_hsa053100.04028678
117Dopaminergic synapse_Homo sapiens_hsa047280.03983099
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03674788
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02932801
120Alzheimers disease_Homo sapiens_hsa050100.02843121
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02449222
122Cardiac muscle contraction_Homo sapiens_hsa042600.00460710
123Influenza A_Homo sapiens_hsa05164-0.0309296
124Huntingtons disease_Homo sapiens_hsa05016-0.0271970
125Legionellosis_Homo sapiens_hsa05134-0.0167563
126Renin secretion_Homo sapiens_hsa04924-0.0159856
127Peroxisome_Homo sapiens_hsa04146-0.0153636
128Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0072634

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