MYRIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.39359030
2synaptic vesicle maturation (GO:0016188)6.15033457
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.82660432
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63951129
5synaptic vesicle exocytosis (GO:0016079)5.53072126
6locomotory exploration behavior (GO:0035641)5.44470668
7glutamate secretion (GO:0014047)5.37339583
8vocalization behavior (GO:0071625)5.36053619
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.20297812
10regulation of synaptic vesicle exocytosis (GO:2000300)5.04353802
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98918724
12regulation of glutamate receptor signaling pathway (GO:1900449)4.79360143
13regulation of synaptic vesicle transport (GO:1902803)4.51492282
14neurotransmitter secretion (GO:0007269)4.51373804
15protein localization to synapse (GO:0035418)4.46940571
16regulation of neuronal synaptic plasticity (GO:0048168)4.39981900
17neuronal action potential propagation (GO:0019227)4.30450308
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.27983823
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24638735
20layer formation in cerebral cortex (GO:0021819)4.23062036
21cellular potassium ion homeostasis (GO:0030007)4.22220217
22exploration behavior (GO:0035640)4.20572765
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16741372
24neuron cell-cell adhesion (GO:0007158)4.14947092
25regulation of synapse structural plasticity (GO:0051823)4.13878158
26sodium ion export (GO:0071436)4.10595215
27cerebellar granule cell differentiation (GO:0021707)4.05594391
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.02826065
29synaptic transmission, glutamatergic (GO:0035249)3.94943519
30amino acid import (GO:0043090)3.93588581
31glutamate receptor signaling pathway (GO:0007215)3.92761735
32cellular sodium ion homeostasis (GO:0006883)3.88119662
33long-term memory (GO:0007616)3.85333954
34neuron-neuron synaptic transmission (GO:0007270)3.82745518
35dendritic spine morphogenesis (GO:0060997)3.79223761
36neurotransmitter transport (GO:0006836)3.74197542
37proline transport (GO:0015824)3.72052580
38positive regulation of membrane potential (GO:0045838)3.71186713
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68726680
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63171552
41neurotransmitter-gated ion channel clustering (GO:0072578)3.61857197
42neuromuscular process controlling posture (GO:0050884)3.60179211
43cerebellar Purkinje cell differentiation (GO:0021702)3.59350102
44gamma-aminobutyric acid transport (GO:0015812)3.59275154
45regulation of postsynaptic membrane potential (GO:0060078)3.58077809
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52291608
47activation of protein kinase A activity (GO:0034199)3.52142741
48synaptic vesicle endocytosis (GO:0048488)3.50082790
49regulation of neurotransmitter levels (GO:0001505)3.46381495
50regulation of synaptic plasticity (GO:0048167)3.45701568
51regulation of neurotransmitter secretion (GO:0046928)3.44902765
52negative regulation of dendrite morphogenesis (GO:0050774)3.43409075
53central nervous system myelination (GO:0022010)3.40353017
54axon ensheathment in central nervous system (GO:0032291)3.40353017
55positive regulation of synapse maturation (GO:0090129)3.39666513
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39070571
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.38102456
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.37801562
59neuron recognition (GO:0008038)3.37251443
60membrane hyperpolarization (GO:0060081)3.36160341
61regulation of dendritic spine morphogenesis (GO:0061001)3.32521128
62long-term synaptic potentiation (GO:0060291)3.30364889
63regulation of vesicle fusion (GO:0031338)3.29873347
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29710498
65cell communication by electrical coupling (GO:0010644)3.29592648
66transmission of nerve impulse (GO:0019226)3.26415452
67serotonin metabolic process (GO:0042428)3.22516409
68positive regulation of neurotransmitter transport (GO:0051590)3.22053551
69regulation of neurotransmitter transport (GO:0051588)3.21750467
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.19548496
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18879757
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18710815
73regulation of ARF protein signal transduction (GO:0032012)3.16200070
74neuromuscular process controlling balance (GO:0050885)3.15914143
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12977509
76neurotransmitter uptake (GO:0001504)3.12920750
77axonal fasciculation (GO:0007413)3.11377994
78response to histamine (GO:0034776)3.11089227
79positive regulation of neurotransmitter secretion (GO:0001956)3.10859312
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10592638
81L-amino acid import (GO:0043092)3.08608841
82cytoskeletal anchoring at plasma membrane (GO:0007016)3.08102839
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08021432
84behavioral fear response (GO:0001662)3.07985367
85behavioral defense response (GO:0002209)3.07985367
86innervation (GO:0060384)3.06828181
87membrane depolarization (GO:0051899)3.03262841
88regulation of synapse maturation (GO:0090128)3.03262056
89membrane depolarization during action potential (GO:0086010)3.02908812
90intraspecies interaction between organisms (GO:0051703)3.02516470
91social behavior (GO:0035176)3.02516470
92mating behavior (GO:0007617)3.01400375
93regulation of clathrin-mediated endocytosis (GO:2000369)3.01171280
94dendrite morphogenesis (GO:0048813)2.99706916
95glycine transport (GO:0015816)2.99213640
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97547036
97regulation of voltage-gated calcium channel activity (GO:1901385)2.97169382
98L-phenylalanine catabolic process (GO:0006559)2.96985706
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.96985706
100acidic amino acid transport (GO:0015800)2.96167824
101prepulse inhibition (GO:0060134)2.95888998
102neuronal ion channel clustering (GO:0045161)2.95587939
103positive regulation of synaptic transmission (GO:0050806)2.94338960
104fear response (GO:0042596)2.93704416
105response to auditory stimulus (GO:0010996)2.93306968
106regulation of cell communication by electrical coupling (GO:0010649)2.93173641
107potassium ion import (GO:0010107)2.92994491
108righting reflex (GO:0060013)2.91729256
109regulation of synaptic transmission (GO:0050804)2.91089672
110learning (GO:0007612)2.90722564
111positive regulation of dendritic spine development (GO:0060999)2.90092116
112synaptic transmission (GO:0007268)2.90055971
113auditory behavior (GO:0031223)2.89512002
114potassium ion homeostasis (GO:0055075)2.89234144
115startle response (GO:0001964)2.88635652
116regulation of dendritic spine development (GO:0060998)2.88217184
117cerebellar Purkinje cell layer development (GO:0021680)2.87105027
118postsynaptic membrane organization (GO:0001941)2.85447510
119primary amino compound metabolic process (GO:1901160)2.83299789
120presynaptic membrane organization (GO:0097090)2.76964211
121cell communication involved in cardiac conduction (GO:0086065)2.73954663
122dendritic spine organization (GO:0097061)2.65906451
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64905882
124L-phenylalanine metabolic process (GO:0006558)2.64905882
125dicarboxylic acid transport (GO:0006835)2.64263459
126cell differentiation in hindbrain (GO:0021533)2.63729227
127negative regulation of dendrite development (GO:2000171)2.60901573
128presynaptic membrane assembly (GO:0097105)2.59080003
129L-glutamate transport (GO:0015813)2.56528967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63101604
2* GBX2_23144817_ChIP-Seq_PC3_Human3.11250986
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00025731
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93523857
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93310298
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66051417
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66051417
8REST_21632747_ChIP-Seq_MESCs_Mouse2.61757939
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52589443
10DROSHA_22980978_ChIP-Seq_HELA_Human2.50589371
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49823184
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48403871
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47726503
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.45957777
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43404984
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36909547
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.36443262
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22317597
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.16190705
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15669113
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15481047
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10706180
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02124772
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95675615
25AR_21572438_ChIP-Seq_LNCaP_Human1.91904242
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87367957
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87108475
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80307412
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78290957
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73724356
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65741079
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64721999
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63804821
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.62178216
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57351345
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50019335
37* ERG_21242973_ChIP-ChIP_JURKAT_Human1.46446042
38TAF15_26573619_Chip-Seq_HEK293_Human1.46180339
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.45337207
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.43799680
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37297045
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33659906
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.31145324
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.29791223
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28814506
46P300_19829295_ChIP-Seq_ESCs_Human1.28458390
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26738625
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26419937
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25671441
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25558216
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.24664719
52* AR_19668381_ChIP-Seq_PC3_Human1.24076717
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24076158
54ZNF274_21170338_ChIP-Seq_K562_Hela1.24025546
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23622042
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23511801
57* STAT3_23295773_ChIP-Seq_U87_Human1.21677304
58AR_25329375_ChIP-Seq_VCAP_Human1.21500056
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21201311
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20219394
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19990467
62* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19764366
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19236324
64IGF1R_20145208_ChIP-Seq_DFB_Human1.17224079
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15088055
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14646190
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.14506173
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14479471
69KDM2B_26808549_Chip-Seq_K562_Human1.14018929
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13546180
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.13336722
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.10465587
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10330760
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.09902430
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09240198
76AHR_22903824_ChIP-Seq_MCF-7_Human1.08967358
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08956067
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08114843
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07120833
80* TCF4_23295773_ChIP-Seq_U87_Human1.06409448
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04646728
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03838781
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03601420
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02738703
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02336962
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01560049
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01555279
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99733044
89SMAD3_21741376_ChIP-Seq_HESCs_Human0.99552206
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99283220
91EP300_21415370_ChIP-Seq_HL-1_Mouse0.99087944
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98713000
93TP53_16413492_ChIP-PET_HCT116_Human0.98583459
94RNF2_27304074_Chip-Seq_NSC_Mouse0.98065031
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98028749
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.97190504
97* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96882748
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.94893581
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94518349
100* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93545708
101RXR_22108803_ChIP-Seq_LS180_Human0.92797929
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92667448
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92309650
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92221706
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.91600884
106* RUNX2_22187159_ChIP-Seq_PCA_Human0.90813424
107* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89761317
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89322617
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88413811
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88413811
111* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87437896
112* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86404898
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85738252
114BCAT_22108803_ChIP-Seq_LS180_Human0.85506152
115* LXR_22158963_ChIP-Seq_LIVER_Mouse0.83721484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.59400630
2MP0003880_abnormal_central_pattern4.72685820
3MP0003635_abnormal_synaptic_transmissio4.13779551
4MP0004270_analgesia3.63777790
5MP0009745_abnormal_behavioral_response3.31630507
6MP0002063_abnormal_learning/memory/cond3.26424051
7MP0002064_seizures3.14973794
8MP0009046_muscle_twitch3.12573658
9MP0005423_abnormal_somatic_nervous3.07079425
10MP0002572_abnormal_emotion/affect_behav2.76246447
11MP0002822_catalepsy2.67606959
12MP0001968_abnormal_touch/_nociception2.66615537
13MP0001486_abnormal_startle_reflex2.64727460
14MP0002272_abnormal_nervous_system2.56832144
15MP0001501_abnormal_sleep_pattern2.55469395
16MP0002734_abnormal_mechanical_nocicepti2.55306140
17MP0003011_delayed_dark_adaptation2.35104376
18MP0002139_abnormal_hepatobiliary_system2.31958176
19MP0009780_abnormal_chondrocyte_physiolo2.00471115
20MP0001440_abnormal_grooming_behavior1.98992521
21MP0002909_abnormal_adrenal_gland1.89489182
22MP0002733_abnormal_thermal_nociception1.87367607
23MP0006276_abnormal_autonomic_nervous1.85042840
24MP0001970_abnormal_pain_threshold1.84815638
25MP0008569_lethality_at_weaning1.83395589
26MP0002067_abnormal_sensory_capabilities1.83176875
27MP0005551_abnormal_eye_electrophysiolog1.82416922
28MP0002736_abnormal_nociception_after1.80110806
29MP0005646_abnormal_pituitary_gland1.74378118
30MP0005386_behavior/neurological_phenoty1.73361675
31MP0004924_abnormal_behavior1.73361675
32MP0002735_abnormal_chemical_nociception1.70888950
33MP0002557_abnormal_social/conspecific_i1.70157882
34MP0003787_abnormal_imprinting1.68247115
35MP0002184_abnormal_innervation1.66642966
36MP0004811_abnormal_neuron_physiology1.65383299
37MP0003879_abnormal_hair_cell1.65188793
38MP0003329_amyloid_beta_deposits1.64529018
39MP0000778_abnormal_nervous_system1.63557234
40MP0001984_abnormal_olfaction1.54515855
41MP0003868_abnormal_feces_composition1.52894856
42MP0004858_abnormal_nervous_system1.52674147
43MP0001502_abnormal_circadian_rhythm1.49762221
44MP0005645_abnormal_hypothalamus_physiol1.47494476
45MP0002882_abnormal_neuron_morphology1.45916171
46MP0004885_abnormal_endolymph1.42032228
47MP0000955_abnormal_spinal_cord1.38078774
48MP0005085_abnormal_gallbladder_physiolo1.37584420
49MP0002066_abnormal_motor_capabilities/c1.36062313
50MP0001905_abnormal_dopamine_level1.33549133
51MP0003633_abnormal_nervous_system1.33082664
52MP0003122_maternal_imprinting1.31911376
53MP0000569_abnormal_digit_pigmentation1.27382078
54MP0005365_abnormal_bile_salt1.24790377
55MP0001529_abnormal_vocalization1.13740924
56MP0002229_neurodegeneration1.12653982
57MP0003631_nervous_system_phenotype1.12584375
58MP0005167_abnormal_blood-brain_barrier1.12223748
59MP0010386_abnormal_urinary_bladder1.10723224
60MP0008875_abnormal_xenobiotic_pharmacok1.10637517
61MP0000751_myopathy1.08710583
62MP0008872_abnormal_physiological_respon1.08614979
63MP0002090_abnormal_vision1.07795507
64MP0002152_abnormal_brain_morphology1.04862841
65MP0004142_abnormal_muscle_tone1.04068162
66MP0004145_abnormal_muscle_electrophysio1.04060311
67MP0006072_abnormal_retinal_apoptosis1.02611483
68MP0002638_abnormal_pupillary_reflex1.01986801
69MP0003123_paternal_imprinting1.00878428
70MP0005360_urolithiasis1.00451086
71MP0005253_abnormal_eye_physiology0.95590421
72MP0008961_abnormal_basal_metabolism0.94191766
73MP0004085_abnormal_heartbeat0.94037648
74MP0005535_abnormal_body_temperature0.93297908
75MP0003075_altered_response_to0.92198001
76MP0005187_abnormal_penis_morphology0.91453502
77MP0002069_abnormal_eating/drinking_beha0.89984844
78MP0001188_hyperpigmentation0.89185005
79MP0001666_abnormal_nutrient_absorption0.88054101
80MP0008874_decreased_physiological_sensi0.88042110
81MP0001986_abnormal_taste_sensitivity0.87230503
82MP0004215_abnormal_myocardial_fiber0.87111952
83MP0004484_altered_response_of0.85759238
84MP0010368_abnormal_lymphatic_system0.84246174
85MP0003690_abnormal_glial_cell0.84107365
86MP0002752_abnormal_somatic_nervous0.83891427
87MP0001177_atelectasis0.82829544
88MP0004147_increased_porphyrin_level0.82296711
89MP0005409_darkened_coat_color0.81991645
90MP0000013_abnormal_adipose_tissue0.78775678
91MP0003632_abnormal_nervous_system0.78489636
92MP0004130_abnormal_muscle_cell0.77103039
93MP0001963_abnormal_hearing_physiology0.76964591
94MP0002837_dystrophic_cardiac_calcinosis0.76706168
95MP0003634_abnormal_glial_cell0.76333881
96MP0004742_abnormal_vestibular_system0.74821400
97MP0004233_abnormal_muscle_weight0.74672108
98MP0010329_abnormal_lipoprotein_level0.74176858
99MP0005623_abnormal_meninges_morphology0.74061367
100MP0000631_abnormal_neuroendocrine_gland0.73209494
101MP0002138_abnormal_hepatobiliary_system0.72199071
102MP0005394_taste/olfaction_phenotype0.71998234
103MP0005499_abnormal_olfactory_system0.71998234
104MP0010234_abnormal_vibrissa_follicle0.68373204
105MP0001664_abnormal_digestion0.68330668
106MP0003283_abnormal_digestive_organ0.68119509
107MP0000604_amyloidosis0.60426260
108MP0000920_abnormal_myelination0.60344019
109MP0003646_muscle_fatigue0.60314236
110MP0004510_myositis0.60302875
111MP0003195_calcinosis0.58063559
112MP0003137_abnormal_impulse_conducting0.57136224
113MP0005195_abnormal_posterior_eye0.57021938
114MP0002234_abnormal_pharynx_morphology0.55059755
115MP0005248_abnormal_Harderian_gland0.54573819
116MP0001943_abnormal_respiration0.54145139
117MP0003183_abnormal_peptide_metabolism0.53668427
118MP0001485_abnormal_pinna_reflex0.52661340
119MP0005670_abnormal_white_adipose0.52064813
120MP0010769_abnormal_survival0.51385169
121MP0008877_abnormal_DNA_methylation0.51270123
122MP0005171_absent_coat_pigmentation0.50696187
123MP0003252_abnormal_bile_duct0.50242608
124MP0002876_abnormal_thyroid_physiology0.49856820

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.66885759
2Myokymia (HP:0002411)6.56123079
3Focal seizures (HP:0007359)5.67378018
4Visual hallucinations (HP:0002367)5.23378881
5Epileptic encephalopathy (HP:0200134)4.90742655
6Febrile seizures (HP:0002373)4.59631033
7Atonic seizures (HP:0010819)4.43015275
8Progressive cerebellar ataxia (HP:0002073)4.35743270
9Absence seizures (HP:0002121)4.30483915
10Generalized tonic-clonic seizures (HP:0002069)4.04500483
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.00482449
12Action tremor (HP:0002345)3.92916033
13Dialeptic seizures (HP:0011146)3.82439263
14Obstructive sleep apnea (HP:0002870)3.34758231
15Broad-based gait (HP:0002136)3.34056621
16Supranuclear gaze palsy (HP:0000605)3.33374717
17Ankle clonus (HP:0011448)3.31758783
18Gaze-evoked nystagmus (HP:0000640)3.31433068
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.31124813
20Impaired vibration sensation in the lower limbs (HP:0002166)3.28689167
21Dysdiadochokinesis (HP:0002075)3.27264845
22Deep venous thrombosis (HP:0002625)3.23512997
23Depression (HP:0000716)3.22223108
24Mutism (HP:0002300)3.21103745
25Urinary bladder sphincter dysfunction (HP:0002839)3.17893449
26Poor eye contact (HP:0000817)3.13766506
27Postural instability (HP:0002172)3.09317048
28Amblyopia (HP:0000646)3.07578468
29Genetic anticipation (HP:0003743)3.06468095
30Dysmetria (HP:0001310)3.03907482
31Abnormal eating behavior (HP:0100738)3.03825100
32Anxiety (HP:0000739)3.03349945
33Papilledema (HP:0001085)3.00939259
34Truncal ataxia (HP:0002078)2.99436473
35Ventricular fibrillation (HP:0001663)2.91996270
36Central scotoma (HP:0000603)2.90793755
37Complement deficiency (HP:0004431)2.90507437
38Impaired social interactions (HP:0000735)2.83959508
39Abnormal social behavior (HP:0012433)2.83959508
40Hyperventilation (HP:0002883)2.81259314
41Hemiparesis (HP:0001269)2.76458878
42Scanning speech (HP:0002168)2.65729673
43Urinary urgency (HP:0000012)2.63787947
44Abnormality of macular pigmentation (HP:0008002)2.61449045
45Impaired smooth pursuit (HP:0007772)2.61105200
46Hemiplegia (HP:0002301)2.60521958
47Abnormality of the lower motor neuron (HP:0002366)2.58314221
48Excessive salivation (HP:0003781)2.57154685
49Drooling (HP:0002307)2.57154685
50Tetraplegia (HP:0002445)2.56892751
51Peripheral hypomyelination (HP:0007182)2.56213022
52Congenital stationary night blindness (HP:0007642)2.48998687
53Dysmetric saccades (HP:0000641)2.48279185
54Torticollis (HP:0000473)2.47710563
55Intention tremor (HP:0002080)2.43549577
56Spastic gait (HP:0002064)2.43273934
57Epileptiform EEG discharges (HP:0011182)2.36427529
58Stereotypic behavior (HP:0000733)2.35937860
59Status epilepticus (HP:0002133)2.35763401
60Sleep apnea (HP:0010535)2.35174622
61Akinesia (HP:0002304)2.32543983
62Bradykinesia (HP:0002067)2.31466722
63Abnormality of ocular smooth pursuit (HP:0000617)2.31008361
64EEG with generalized epileptiform discharges (HP:0011198)2.29164995
65Insidious onset (HP:0003587)2.27169407
66Termporal pattern (HP:0011008)2.27169407
67Progressive inability to walk (HP:0002505)2.25522819
68Focal dystonia (HP:0004373)2.24842564
69Impaired vibratory sensation (HP:0002495)2.24633513
70Neurofibrillary tangles (HP:0002185)2.21811296
71Megalencephaly (HP:0001355)2.20617236
72Apathy (HP:0000741)2.19604999
73Abnormality of binocular vision (HP:0011514)2.18544206
74Diplopia (HP:0000651)2.18544206
75Scotoma (HP:0000575)2.16907236
76Cerebral inclusion bodies (HP:0100314)2.16654678
77Fetal akinesia sequence (HP:0001989)2.16526035
78Absent speech (HP:0001344)2.16513083
79Generalized myoclonic seizures (HP:0002123)2.14160179
80Lower limb muscle weakness (HP:0007340)2.13978743
81Prolonged partial thromboplastin time (HP:0003645)2.12592056
82Cerebral hypomyelination (HP:0006808)2.12131236
83Hypsarrhythmia (HP:0002521)2.10850028
84Intrahepatic cholestasis (HP:0001406)2.10803965
85Hyperthyroidism (HP:0000836)2.04292226
86Agitation (HP:0000713)2.04248686
87Bundle branch block (HP:0011710)2.03305120
88Abnormal EKG (HP:0003115)2.02278920
89Polyphagia (HP:0002591)2.01323108
90Limb dystonia (HP:0002451)1.99152401
91Increased circulating renin level (HP:0000848)1.99091593
92Abnormality of complement system (HP:0005339)1.99021108
93Craniofacial dystonia (HP:0012179)1.98861560
94Inability to walk (HP:0002540)1.97636728
95Prolonged QT interval (HP:0001657)1.97180636
96Pheochromocytoma (HP:0002666)1.97035244
97Diminished motivation (HP:0000745)1.96741914
98Incomplete penetrance (HP:0003829)1.96364138
99Abnormality of the corticospinal tract (HP:0002492)1.95843859
100Choroideremia (HP:0001139)1.95831760
101Spinal canal stenosis (HP:0003416)1.95322196
102Hyperlipoproteinemia (HP:0010980)1.95272642
103Annular pancreas (HP:0001734)1.95240886
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94801781
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.94801781
106Morphological abnormality of the pyramidal tract (HP:0002062)1.92604485
107Choreoathetosis (HP:0001266)1.92365510
108Gait ataxia (HP:0002066)1.91020472
109Blue irides (HP:0000635)1.83441043
110Heart block (HP:0012722)1.81116568
111Insomnia (HP:0100785)1.80957498
112Lower limb asymmetry (HP:0100559)1.80456204
113Rigidity (HP:0002063)1.79873364
114Gonadotropin excess (HP:0000837)1.79566773
115Pointed chin (HP:0000307)1.79383541
116Specific learning disability (HP:0001328)1.78393591
117Rapidly progressive (HP:0003678)1.78347492
118Clonus (HP:0002169)1.77079858
119Hypoventilation (HP:0002791)1.76930377
120Joint hemorrhage (HP:0005261)1.76667291
121Neuronal loss in central nervous system (HP:0002529)1.75789115
122Syncope (HP:0001279)1.75481056
123Bony spicule pigmentary retinopathy (HP:0007737)1.73813145
124Abnormality of salivation (HP:0100755)1.73386953
125Delusions (HP:0000746)1.72746880
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71425395
127Psychosis (HP:0000709)1.71298941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51023369
2EPHA44.15813649
3MAP3K94.08508810
4MAP3K43.19994043
5TIE13.18307736
6PAK62.68626991
7DAPK22.67624250
8PRKD32.52736215
9MAP2K72.46126483
10MINK12.44494575
11MARK12.31261541
12KSR22.30645040
13NTRK22.12793451
14MAP2K42.00216870
15NTRK11.99865318
16CAMKK11.92053388
17MAP3K121.81377031
18STK381.67771542
19RIPK41.59224188
20MAP3K131.57956516
21KSR11.54371178
22CDK51.53572833
23DAPK11.45159552
24GRK51.39728254
25PLK21.32232721
26ARAF1.27299398
27PNCK1.23285506
28CAMKK21.19892142
29TYRO31.17560568
30CDK191.17364745
31STK391.17317744
32MAPK131.16583506
33CASK1.16506262
34TNIK1.15859537
35CAMK11.14526444
36TAOK11.12655295
37SIK21.10269269
38LATS21.10136632
39FES1.08710728
40PRKCG1.06866868
41UHMK11.06233751
42MAP3K21.06149543
43CAMK1G1.04590137
44FGFR21.03632999
45PRPF4B1.00950777
46CAMK2A1.00316499
47PAK31.00127764
48STK110.97269691
49PRKCH0.95983387
50PINK10.95091989
51AKT30.94770557
52SGK2230.92446719
53SGK4940.92446719
54RET0.88112772
55PHKG10.87688776
56PHKG20.87688776
57LMTK20.85132013
58RIPK10.84763931
59RAF10.82836664
60CDK150.77050397
61CDK180.76916528
62PTK2B0.75993229
63MAP3K60.75673983
64CDK140.73747464
65SGK20.72798679
66MARK20.72135703
67SGK10.70854291
68CSNK1G20.69352475
69PKN10.69212079
70SGK30.68277638
71MAP3K70.67653791
72CAMK2B0.66839983
73PDK10.66267194
74OXSR10.65656646
75CDK11A0.65326018
76PRKG20.65059259
77ALK0.64396289
78DYRK1A0.64010188
79PDPK10.63222640
80MAP3K10.60492024
81BMPR20.59520213
82NEK10.56296905
83DDR20.55864111
84TRIB30.54711334
85CAMK40.54087131
86MUSK0.54081559
87TNK20.53837466
88RPS6KA30.53205103
89PRKCZ0.52317791
90EEF2K0.51896597
91DMPK0.51054340
92FER0.50704945
93MAPK100.49294247
94CAMK1D0.48836163
95CDC42BPA0.46490102
96PRKG10.46313231
97PRKCE0.46096482
98MAP2K10.45622481
99CAMK2D0.44546415
100CAMK2G0.42392279
101WNK10.41456158
102FRK0.41019612
103NME10.40425470
104NEK60.39670845
105ROCK20.39166129
106BRAF0.38620803
107WNK30.38406394
108PRKD20.37601851
109PRKD10.36680712
110MAPKAPK50.36604643
111DAPK30.36558422
112ROCK10.35930603
113FYN0.35523567
114MAPK120.35293627
115CCNB10.35092256
116PRKCA0.33302339
117ICK0.32507347
118CSNK1D0.31406740
119CSNK1A10.31003124

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46581689
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21932023
3Olfactory transduction_Homo sapiens_hsa047402.74055994
4GABAergic synapse_Homo sapiens_hsa047272.67154158
5Circadian entrainment_Homo sapiens_hsa047132.56595347
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56576930
7Glutamatergic synapse_Homo sapiens_hsa047242.46683717
8Long-term potentiation_Homo sapiens_hsa047202.41661385
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40594131
10Morphine addiction_Homo sapiens_hsa050322.39245403
11Amphetamine addiction_Homo sapiens_hsa050312.29849213
12Salivary secretion_Homo sapiens_hsa049702.21180450
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19835625
14Insulin secretion_Homo sapiens_hsa049112.12205627
15Dopaminergic synapse_Homo sapiens_hsa047282.07588724
16Gastric acid secretion_Homo sapiens_hsa049711.91193480
17Cholinergic synapse_Homo sapiens_hsa047251.88748271
18Histidine metabolism_Homo sapiens_hsa003401.87944015
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85421574
20Phototransduction_Homo sapiens_hsa047441.81801526
21Phenylalanine metabolism_Homo sapiens_hsa003601.76305075
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68084168
23Renin secretion_Homo sapiens_hsa049241.67862710
24Serotonergic synapse_Homo sapiens_hsa047261.66392972
25Oxytocin signaling pathway_Homo sapiens_hsa049211.64309501
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.63656384
27Vitamin B6 metabolism_Homo sapiens_hsa007501.62260251
28Taste transduction_Homo sapiens_hsa047421.61911490
29Nitrogen metabolism_Homo sapiens_hsa009101.60490501
30Cocaine addiction_Homo sapiens_hsa050301.60038207
31Long-term depression_Homo sapiens_hsa047301.56205828
32Calcium signaling pathway_Homo sapiens_hsa040201.51790664
33GnRH signaling pathway_Homo sapiens_hsa049121.47872617
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42717233
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42400265
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33098171
37cAMP signaling pathway_Homo sapiens_hsa040241.30697912
38Gap junction_Homo sapiens_hsa045401.28285967
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25408473
40Caffeine metabolism_Homo sapiens_hsa002321.23481015
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18639898
42Type II diabetes mellitus_Homo sapiens_hsa049301.17847786
43Retinol metabolism_Homo sapiens_hsa008301.16638118
44Complement and coagulation cascades_Homo sapiens_hsa046101.13840539
45Collecting duct acid secretion_Homo sapiens_hsa049661.13507065
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12774993
47Estrogen signaling pathway_Homo sapiens_hsa049151.11526421
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10466545
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10248666
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09315712
51Glioma_Homo sapiens_hsa052141.09176333
52Tyrosine metabolism_Homo sapiens_hsa003501.09119350
53Pancreatic secretion_Homo sapiens_hsa049721.06001917
54Arginine and proline metabolism_Homo sapiens_hsa003301.05861349
55Dorso-ventral axis formation_Homo sapiens_hsa043201.05363694
56beta-Alanine metabolism_Homo sapiens_hsa004101.00184903
57Melanogenesis_Homo sapiens_hsa049160.99066928
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.98510602
59Cardiac muscle contraction_Homo sapiens_hsa042600.98292005
60Axon guidance_Homo sapiens_hsa043600.96877542
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95190198
62ErbB signaling pathway_Homo sapiens_hsa040120.94929837
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.91746649
64Dilated cardiomyopathy_Homo sapiens_hsa054140.89894542
65Fatty acid biosynthesis_Homo sapiens_hsa000610.84107143
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83904210
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80144600
68Oocyte meiosis_Homo sapiens_hsa041140.79752926
69Fatty acid degradation_Homo sapiens_hsa000710.78655078
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77733746
71Choline metabolism in cancer_Homo sapiens_hsa052310.77227163
72Butanoate metabolism_Homo sapiens_hsa006500.76718383
73ABC transporters_Homo sapiens_hsa020100.76350108
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.75609500
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75568477
76Circadian rhythm_Homo sapiens_hsa047100.75523264
77Thyroid hormone synthesis_Homo sapiens_hsa049180.74152909
78Chemical carcinogenesis_Homo sapiens_hsa052040.73889123
79Vibrio cholerae infection_Homo sapiens_hsa051100.73424819
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71679162
81MAPK signaling pathway_Homo sapiens_hsa040100.70919413
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68748152
83Bile secretion_Homo sapiens_hsa049760.66291001
84VEGF signaling pathway_Homo sapiens_hsa043700.64616409
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63841907
86PPAR signaling pathway_Homo sapiens_hsa033200.63656718
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62441561
88Ras signaling pathway_Homo sapiens_hsa040140.62349562
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62280476
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61621125
91Tryptophan metabolism_Homo sapiens_hsa003800.61009204
92Glucagon signaling pathway_Homo sapiens_hsa049220.60066738
93mTOR signaling pathway_Homo sapiens_hsa041500.59872965
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.57052875
95Rap1 signaling pathway_Homo sapiens_hsa040150.56807562
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55853948
97Inositol phosphate metabolism_Homo sapiens_hsa005620.55480209
98Ovarian steroidogenesis_Homo sapiens_hsa049130.52850335
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.52080610
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50903446
101Endocytosis_Homo sapiens_hsa041440.50690922
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48818012
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.48440185
104Renal cell carcinoma_Homo sapiens_hsa052110.48314297
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47986146
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47630170
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47031951
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45330007
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44956168
110Type I diabetes mellitus_Homo sapiens_hsa049400.43288791
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42799844
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41548703
113Alcoholism_Homo sapiens_hsa050340.40689596
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40480078
115Endometrial cancer_Homo sapiens_hsa052130.40381776
116Insulin signaling pathway_Homo sapiens_hsa049100.40042570
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39320849
118Non-small cell lung cancer_Homo sapiens_hsa052230.37956471
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.37782949
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37146301
121Wnt signaling pathway_Homo sapiens_hsa043100.37125146
122Linoleic acid metabolism_Homo sapiens_hsa005910.36090111
123Prion diseases_Homo sapiens_hsa050200.33408325
124Chemokine signaling pathway_Homo sapiens_hsa040620.30289991
125African trypanosomiasis_Homo sapiens_hsa051430.30152998
126Mineral absorption_Homo sapiens_hsa049780.27203400
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27184973
128Arginine biosynthesis_Homo sapiens_hsa002200.26170832
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25675724
130Tight junction_Homo sapiens_hsa045300.24947000

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »