MYT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.50353324
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49387362
3behavioral response to nicotine (GO:0035095)4.48294183
4pyrimidine nucleobase catabolic process (GO:0006208)4.41193045
5establishment of mitochondrion localization (GO:0051654)4.40472957
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39923990
7cell migration in hindbrain (GO:0021535)4.37261564
8axonal fasciculation (GO:0007413)4.32196481
9neurotransmitter-gated ion channel clustering (GO:0072578)4.15127692
10response to pheromone (GO:0019236)4.15097164
11cerebellar Purkinje cell differentiation (GO:0021702)4.00689319
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.91403885
13neuron recognition (GO:0008038)3.86728201
14layer formation in cerebral cortex (GO:0021819)3.84628801
15mitochondrion transport along microtubule (GO:0047497)3.79275444
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.79275444
17dendritic spine morphogenesis (GO:0060997)3.77821975
18innervation (GO:0060384)3.75375010
19central nervous system projection neuron axonogenesis (GO:0021952)3.71642165
20dendrite morphogenesis (GO:0048813)3.69739987
21regulation of synaptic vesicle exocytosis (GO:2000300)3.57752850
22cerebellum development (GO:0021549)3.51647291
23glutamate secretion (GO:0014047)3.49619269
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43752542
25synaptic vesicle maturation (GO:0016188)3.42459833
26protein localization to synapse (GO:0035418)3.39439952
27synaptic vesicle exocytosis (GO:0016079)3.36017807
28locomotory exploration behavior (GO:0035641)3.34592785
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30668471
30mating behavior (GO:0007617)3.26532149
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25770793
32cell differentiation in hindbrain (GO:0021533)3.24786860
33neuromuscular synaptic transmission (GO:0007274)3.22865386
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.22214950
35vocalization behavior (GO:0071625)3.17579764
36nucleobase catabolic process (GO:0046113)3.15870664
37axon extension (GO:0048675)3.15673179
38axon ensheathment in central nervous system (GO:0032291)3.15337340
39central nervous system myelination (GO:0022010)3.15337340
40positive regulation of synapse maturation (GO:0090129)3.14703843
41synapse assembly (GO:0007416)3.11819589
42adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.11783467
43regulation of synaptic vesicle transport (GO:1902803)3.09460431
44auditory behavior (GO:0031223)3.06520872
45substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.05927167
46substrate-independent telencephalic tangential migration (GO:0021826)3.05927167
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04167125
48retinal ganglion cell axon guidance (GO:0031290)3.03761507
49endocrine pancreas development (GO:0031018)3.02488848
50presynaptic membrane organization (GO:0097090)3.01934232
51dendritic spine organization (GO:0097061)3.01601690
52central nervous system neuron axonogenesis (GO:0021955)3.00341634
53membrane depolarization during action potential (GO:0086010)2.99612599
54synaptic transmission, glutamatergic (GO:0035249)2.99015523
55positive regulation of dendritic spine morphogenesis (GO:0061003)2.98894801
56postsynaptic membrane organization (GO:0001941)2.96909168
57forebrain neuron differentiation (GO:0021879)2.95639928
58neuron fate specification (GO:0048665)2.95166189
59neurotransmitter secretion (GO:0007269)2.94386640
60neurofilament cytoskeleton organization (GO:0060052)2.92732501
61hippocampus development (GO:0021766)2.92621331
62calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.91265660
63insulin secretion (GO:0030073)2.90446004
64regulation of respiratory gaseous exchange (GO:0043576)2.88549074
65negative regulation of axonogenesis (GO:0050771)2.87950093
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87938808
67glandular epithelial cell differentiation (GO:0002067)2.86697624
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86456761
69cerebellar Purkinje cell layer development (GO:0021680)2.85974222
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.85597885
71spinal cord motor neuron differentiation (GO:0021522)2.85537278
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.85155852
73chemosensory behavior (GO:0007635)2.85154645
74epithelial cell fate commitment (GO:0072148)2.82504231
75nonmotile primary cilium assembly (GO:0035058)2.81263713
76synaptic transmission, cholinergic (GO:0007271)2.80790805
77retinal rod cell development (GO:0046548)2.80654642
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.80647962
79synaptic vesicle endocytosis (GO:0048488)2.80442392
80cell communication by electrical coupling (GO:0010644)2.79777034
81photoreceptor cell development (GO:0042461)2.79414552
82neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.77561503
83regulation of postsynaptic membrane potential (GO:0060078)2.77497353
84regulation of synapse structural plasticity (GO:0051823)2.76779953
85regulation of glutamate receptor signaling pathway (GO:1900449)2.76772193
86neurotransmitter transport (GO:0006836)2.75975401
87positive regulation of synapse assembly (GO:0051965)2.75611246
88cerebellar granule cell differentiation (GO:0021707)2.75360055
89presynaptic membrane assembly (GO:0097105)2.75341122
90stress granule assembly (GO:0034063)2.75078824
91cerebral cortex radially oriented cell migration (GO:0021799)2.74639028
92positive regulation of membrane potential (GO:0045838)2.73709655
93negative regulation of axon extension (GO:0030517)2.73456464
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72877349
95regulation of synapse assembly (GO:0051963)2.71321374
96cornea development in camera-type eye (GO:0061303)2.70974772
97dendrite development (GO:0016358)2.69846022
98detection of light stimulus involved in visual perception (GO:0050908)2.69106884
99detection of light stimulus involved in sensory perception (GO:0050962)2.69106884
100regulation of neurotransmitter secretion (GO:0046928)2.68660902
101axonogenesis (GO:0007409)2.68432279
102eye photoreceptor cell development (GO:0042462)2.67344027
103startle response (GO:0001964)2.66776878
104astrocyte differentiation (GO:0048708)2.65225833
105regulation of neuronal synaptic plasticity (GO:0048168)2.65089767
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63739130
107spinal cord development (GO:0021510)2.62654822
108synapse organization (GO:0050808)2.62315699
109response to auditory stimulus (GO:0010996)2.62219329
110neuronal ion channel clustering (GO:0045161)2.61917348
111regulation of synapse maturation (GO:0090128)2.61670503
112photoreceptor cell maintenance (GO:0045494)2.61493167
113glutamate receptor signaling pathway (GO:0007215)2.61479182
114neuron-neuron synaptic transmission (GO:0007270)2.61457833
115regulation of respiratory system process (GO:0044065)2.61373194
116hindbrain development (GO:0030902)2.60990756
117membrane hyperpolarization (GO:0060081)2.60151268
118neuron migration (GO:0001764)2.59847739
119cell differentiation in spinal cord (GO:0021515)2.58185506
120mechanosensory behavior (GO:0007638)2.57541929
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.56220122
122neuronal action potential propagation (GO:0019227)2.55971965
123exploration behavior (GO:0035640)2.55252922
124transmission of nerve impulse (GO:0019226)2.53294225
125sympathetic nervous system development (GO:0048485)2.52801160
126glandular epithelial cell development (GO:0002068)2.51938296
127ganglion development (GO:0061548)2.51918219
128regulation of vesicle fusion (GO:0031338)2.51763216
129gamma-aminobutyric acid transport (GO:0015812)2.51142636
130homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.50906598
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50729828
132central nervous system neuron differentiation (GO:0021953)2.49646423
133adult walking behavior (GO:0007628)2.49594016
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.49404871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90226797
2GBX2_23144817_ChIP-Seq_PC3_Human3.04812361
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.78117826
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64956075
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60659259
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.59363271
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55303995
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51983996
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.49692362
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47393908
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47393908
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38255284
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37484724
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32439584
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.28301027
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.25880695
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24129123
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19028881
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18508990
20IGF1R_20145208_ChIP-Seq_DFB_Human2.17267768
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07372898
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05223851
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.05149460
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02333847
25DROSHA_22980978_ChIP-Seq_HELA_Human2.00502086
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.00468461
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88984828
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87484549
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81508776
30ZNF274_21170338_ChIP-Seq_K562_Hela1.81244804
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.78999548
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78778378
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76639944
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72557916
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67885689
36* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.65037567
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63381922
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56602690
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54727503
40RNF2_27304074_Chip-Seq_NSC_Mouse1.54470856
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.48169636
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.47738329
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47618173
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46167772
45SMAD4_21799915_ChIP-Seq_A2780_Human1.39942856
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30543673
47TAF15_26573619_Chip-Seq_HEK293_Human1.29824065
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29021981
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26487987
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24668327
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24225687
52STAT3_23295773_ChIP-Seq_U87_Human1.23816058
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.23279653
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22864985
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22774393
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22552060
57AR_19668381_ChIP-Seq_PC3_Human1.22441450
58P300_19829295_ChIP-Seq_ESCs_Human1.22433332
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20669466
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20091908
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18976915
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17954936
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16143473
64AHR_22903824_ChIP-Seq_MCF-7_Human1.15265094
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14731324
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14731324
67KDM2B_26808549_Chip-Seq_K562_Human1.14248944
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12863835
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12585072
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.11081930
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10735651
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10617702
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.10346012
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.09579580
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09456311
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09374861
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08034309
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.07349307
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06577036
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05624669
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05398990
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04828693
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04195946
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03637008
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.03357602
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02995333
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02774957
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02715952
89AR_25329375_ChIP-Seq_VCAP_Human1.01788516
90RUNX2_22187159_ChIP-Seq_PCA_Human1.00656363
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00626330
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00610149
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.00516359
94AR_21572438_ChIP-Seq_LNCaP_Human1.00451851
95TCF4_23295773_ChIP-Seq_U87_Human1.00224019
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98708697
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98493948
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.97607179
99FUS_26573619_Chip-Seq_HEK293_Human0.97563278
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96015529
101P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95765880
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.95125490
103* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95119447
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93006842
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92145309
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91652405
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91621681
108VDR_22108803_ChIP-Seq_LS180_Human0.91361126
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91146277
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90906628
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89929075
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88661929
113CTCF_27219007_Chip-Seq_Bcells_Human0.86393598
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85422293
115* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84235834
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84129220
117CBP_20019798_ChIP-Seq_JUKART_Human0.84061291
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84061291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.50987903
2MP0002822_catalepsy3.08846205
3MP0004270_analgesia2.82164606
4MP0006072_abnormal_retinal_apoptosis2.81910246
5MP0005423_abnormal_somatic_nervous2.72684587
6MP0000778_abnormal_nervous_system2.57243096
7MP0003635_abnormal_synaptic_transmissio2.44088428
8MP0003880_abnormal_central_pattern2.41464757
9MP0002184_abnormal_innervation2.40348476
10MP0006276_abnormal_autonomic_nervous2.38204449
11MP0005645_abnormal_hypothalamus_physiol2.37868746
12MP0002638_abnormal_pupillary_reflex2.36712657
13MP0006292_abnormal_olfactory_placode2.30540338
14MP0005551_abnormal_eye_electrophysiolog2.25393198
15MP0003787_abnormal_imprinting2.24388417
16MP0008789_abnormal_olfactory_epithelium2.23412681
17MP0002653_abnormal_ependyma_morphology2.20245495
18MP0002734_abnormal_mechanical_nocicepti2.19691862
19MP0002909_abnormal_adrenal_gland2.15831380
20MP0003123_paternal_imprinting2.12768360
21MP0001968_abnormal_touch/_nociception2.10310318
22MP0005394_taste/olfaction_phenotype2.09387669
23MP0005499_abnormal_olfactory_system2.09387669
24MP0002063_abnormal_learning/memory/cond2.03668494
25MP0005253_abnormal_eye_physiology1.98002647
26MP0000631_abnormal_neuroendocrine_gland1.93014010
27MP0005646_abnormal_pituitary_gland1.90146769
28MP0000955_abnormal_spinal_cord1.89315072
29MP0001984_abnormal_olfaction1.86863506
30MP0003283_abnormal_digestive_organ1.86553893
31MP0002735_abnormal_chemical_nociception1.82376125
32MP0005187_abnormal_penis_morphology1.81607991
33MP0002751_abnormal_autonomic_nervous1.76962420
34MP0010386_abnormal_urinary_bladder1.75811756
35MP0009046_muscle_twitch1.73145501
36MP0002572_abnormal_emotion/affect_behav1.73027748
37MP0002067_abnormal_sensory_capabilities1.71927423
38MP0004811_abnormal_neuron_physiology1.71376938
39MP0002557_abnormal_social/conspecific_i1.70197623
40MP0002272_abnormal_nervous_system1.69848583
41MP0002882_abnormal_neuron_morphology1.69627661
42MP0009745_abnormal_behavioral_response1.69540218
43MP0002733_abnormal_thermal_nociception1.68395077
44MP0004858_abnormal_nervous_system1.66949360
45MP0002736_abnormal_nociception_after1.64830946
46MP0002064_seizures1.63197327
47MP0001486_abnormal_startle_reflex1.62834329
48MP0001502_abnormal_circadian_rhythm1.58546728
49MP0003183_abnormal_peptide_metabolism1.57180644
50MP0003122_maternal_imprinting1.50950179
51MP0001970_abnormal_pain_threshold1.45746177
52MP0008877_abnormal_DNA_methylation1.45154106
53MP0000569_abnormal_digit_pigmentation1.41922014
54* MP0001944_abnormal_pancreas_morphology1.39535931
55MP0004885_abnormal_endolymph1.37944972
56MP0009780_abnormal_chondrocyte_physiolo1.37890851
57MP0002752_abnormal_somatic_nervous1.36346156
58MP0004133_heterotaxia1.30781840
59MP0002152_abnormal_brain_morphology1.29346814
60MP0008569_lethality_at_weaning1.27892743
61MP0002234_abnormal_pharynx_morphology1.26422783
62MP0004742_abnormal_vestibular_system1.26358993
63MP0003890_abnormal_embryonic-extraembry1.24503852
64MP0001905_abnormal_dopamine_level1.24251046
65MP0003861_abnormal_nervous_system1.23962683
66MP0000678_abnormal_parathyroid_gland1.22236303
67MP0001986_abnormal_taste_sensitivity1.22146191
68MP0004043_abnormal_pH_regulation1.18341644
69MP0008961_abnormal_basal_metabolism1.18144814
70MP0002229_neurodegeneration1.17259008
71MP0003121_genomic_imprinting1.16444308
72MP0004145_abnormal_muscle_electrophysio1.15089507
73MP0002102_abnormal_ear_morphology1.14514447
74* MP0002693_abnormal_pancreas_physiology1.13908712
75MP0005195_abnormal_posterior_eye1.12923874
76MP0005386_behavior/neurological_phenoty1.12136709
77MP0004924_abnormal_behavior1.12136709
78MP0001188_hyperpigmentation1.10926600
79MP0003879_abnormal_hair_cell1.07147779
80MP0001440_abnormal_grooming_behavior1.06533327
81MP0002066_abnormal_motor_capabilities/c1.06372222
82MP0001324_abnormal_eye_pigmentation1.04081778
83MP0001529_abnormal_vocalization1.02954084
84MP0001485_abnormal_pinna_reflex0.97269974
85MP0005391_vision/eye_phenotype0.96041017
86MP0003633_abnormal_nervous_system0.95228053
87MP0001270_distended_abdomen0.94758043
88MP0002069_abnormal_eating/drinking_beha0.94129642
89MP0001299_abnormal_eye_distance/0.91831969
90MP0002877_abnormal_melanocyte_morpholog0.91265449
91MP0000049_abnormal_middle_ear0.91222157
92MP0003119_abnormal_digestive_system0.90987609
93MP0005248_abnormal_Harderian_gland0.90311627
94MP0003329_amyloid_beta_deposits0.90126502
95MP0005379_endocrine/exocrine_gland_phen0.89727991
96MP0003634_abnormal_glial_cell0.88164482
97MP0000013_abnormal_adipose_tissue0.87146608
98MP0002163_abnormal_gland_morphology0.85956620
99MP0003385_abnormal_body_wall0.85179519
100MP0001501_abnormal_sleep_pattern0.84908581
101MP0005257_abnormal_intraocular_pressure0.84659675
102MP0003938_abnormal_ear_development0.84636573
103MP0003631_nervous_system_phenotype0.83065508
104MP0008995_early_reproductive_senescence0.81672592
105MP0005220_abnormal_exocrine_pancreas0.81332982
106MP0000026_abnormal_inner_ear0.80370211
107MP0002938_white_spotting0.78645047
108MP0004142_abnormal_muscle_tone0.78546328
109MP0001963_abnormal_hearing_physiology0.76909029
110MP0005409_darkened_coat_color0.75753619
111MP0003137_abnormal_impulse_conducting0.74841433
112MP0000566_synostosis0.74469141
113MP0000534_abnormal_ureter_morphology0.74461241
114MP0004085_abnormal_heartbeat0.71433515
115MP0001943_abnormal_respiration0.70922013
116* MP0002081_perinatal_lethality0.70470970
117MP0002116_abnormal_craniofacial_bone0.67273471
118MP0003632_abnormal_nervous_system0.67270865
119MP0002177_abnormal_outer_ear0.66718377
120MP0002090_abnormal_vision0.66403644
121MP0001177_atelectasis0.65847365
122MP0008872_abnormal_physiological_respon0.65574648

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.84436910
2Congenital stationary night blindness (HP:0007642)3.80574806
3Central scotoma (HP:0000603)3.38153255
4Polyphagia (HP:0002591)3.36718358
5Progressive cerebellar ataxia (HP:0002073)3.34307779
6Agitation (HP:0000713)3.33177852
7Hyperventilation (HP:0002883)3.31817365
8Abnormal rod and cone electroretinograms (HP:0008323)3.10270541
9Visual hallucinations (HP:0002367)3.03705434
10Febrile seizures (HP:0002373)3.03344636
11Bony spicule pigmentary retinopathy (HP:0007737)3.03222870
12Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90142885
13Abnormality of macular pigmentation (HP:0008002)2.89770739
14Focal motor seizures (HP:0011153)2.88191490
15Abnormality of the labia minora (HP:0012880)2.82347897
16Focal seizures (HP:0007359)2.80962979
17Pendular nystagmus (HP:0012043)2.71260945
18Myokymia (HP:0002411)2.67232070
19Abnormality of calcium-phosphate metabolism (HP:0100530)2.64692899
20Urinary bladder sphincter dysfunction (HP:0002839)2.61689740
21Abnormal eating behavior (HP:0100738)2.59578280
22Insomnia (HP:0100785)2.56963251
23Pachygyria (HP:0001302)2.55648530
24Action tremor (HP:0002345)2.48797058
25Elfin facies (HP:0004428)2.47936899
26Epileptic encephalopathy (HP:0200134)2.47700214
27EEG with generalized epileptiform discharges (HP:0011198)2.47297885
28Type II diabetes mellitus (HP:0005978)2.45251364
29Pheochromocytoma (HP:0002666)2.44887782
30Macroorchidism (HP:0000053)2.44875495
31Spastic gait (HP:0002064)2.43457570
32Hyperinsulinemic hypoglycemia (HP:0000825)2.43307420
33Abnormality of the parathyroid morphology (HP:0011766)2.42434743
34Scotoma (HP:0000575)2.42241183
35Fetal akinesia sequence (HP:0001989)2.40261768
36Neoplasm of the heart (HP:0100544)2.39948992
37Hypsarrhythmia (HP:0002521)2.39843619
38Epileptiform EEG discharges (HP:0011182)2.39431966
39Hyperacusis (HP:0010780)2.36745245
40Medial flaring of the eyebrow (HP:0010747)2.36204552
41Truncal ataxia (HP:0002078)2.34450471
42Severe visual impairment (HP:0001141)2.34160384
43Excessive salivation (HP:0003781)2.31607077
44Drooling (HP:0002307)2.31607077
45Sleep apnea (HP:0010535)2.30599557
46Retinal dysplasia (HP:0007973)2.29987372
47Failure to thrive in infancy (HP:0001531)2.29112692
48Exotropia (HP:0000577)2.28785928
49Amblyopia (HP:0000646)2.27582908
50Hypoglycemic seizures (HP:0002173)2.25703332
51Poor suck (HP:0002033)2.25688089
52Genetic anticipation (HP:0003743)2.23969636
53Nephrogenic diabetes insipidus (HP:0009806)2.22305610
54Intestinal atresia (HP:0011100)2.20389326
55Abnormality of the lower motor neuron (HP:0002366)2.19357824
56Urinary urgency (HP:0000012)2.19320027
57Symptomatic seizures (HP:0011145)2.19052582
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.18587292
59Hypoplasia of the fovea (HP:0007750)2.18587292
60Congenital primary aphakia (HP:0007707)2.18529037
61Congenital malformation of the right heart (HP:0011723)2.17510325
62Double outlet right ventricle (HP:0001719)2.17510325
63Limb dystonia (HP:0002451)2.17164005
64Decreased central vision (HP:0007663)2.15214832
65Hypothermia (HP:0002045)2.13252928
66Hypoplasia of the brainstem (HP:0002365)2.10398231
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10398231
68Abolished electroretinogram (ERG) (HP:0000550)2.10069320
69Supranuclear gaze palsy (HP:0000605)2.08595250
70Nephronophthisis (HP:0000090)2.08348868
71Shawl scrotum (HP:0000049)2.05981702
72Vaginal atresia (HP:0000148)2.05348637
73Renovascular hypertension (HP:0100817)2.04522646
74Abnormal pancreas size (HP:0012094)2.03355106
75Hemiparesis (HP:0001269)2.01550513
76Genital tract atresia (HP:0001827)2.01327653
77Menstrual irregularities (HP:0000858)2.00926721
78Morphological abnormality of the pyramidal tract (HP:0002062)1.99357851
79Overriding aorta (HP:0002623)1.98738603
80Chorioretinal atrophy (HP:0000533)1.98725278
81Oligodactyly (hands) (HP:0001180)1.98697650
82Depression (HP:0000716)1.98640450
83Gaze-evoked nystagmus (HP:0000640)1.97848389
84Neuroendocrine neoplasm (HP:0100634)1.96959843
85Atonic seizures (HP:0010819)1.95610121
86Neoplasm of the adrenal cortex (HP:0100641)1.95509497
87Insulin-resistant diabetes mellitus (HP:0000831)1.95013884
88Abnormality of the fovea (HP:0000493)1.94424148
89Hypoplasia of the corpus callosum (HP:0002079)1.94356849
90Torticollis (HP:0000473)1.93312964
91Broad-based gait (HP:0002136)1.92754786
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92299980
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.92299980
94Absence seizures (HP:0002121)1.91536972
95Impaired smooth pursuit (HP:0007772)1.91036859
96Abnormality of the corticospinal tract (HP:0002492)1.90828958
97Poor coordination (HP:0002370)1.88873566
98Pancreatic fibrosis (HP:0100732)1.87939753
99Papillary thyroid carcinoma (HP:0002895)1.87482293
100Status epilepticus (HP:0002133)1.87200901
101Abnormality of midbrain morphology (HP:0002418)1.84882780
102Molar tooth sign on MRI (HP:0002419)1.84882780
103Anteriorly placed anus (HP:0001545)1.84827560
104True hermaphroditism (HP:0010459)1.84396588
105Oligodactyly (HP:0012165)1.84026649
106Lissencephaly (HP:0001339)1.83678635
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83349721
108Specific learning disability (HP:0001328)1.82754707
109Anxiety (HP:0000739)1.81535719
110Renal duplication (HP:0000075)1.80330076
111Esotropia (HP:0000565)1.80171963
112Dyschromatopsia (HP:0007641)1.79746992
113Anosmia (HP:0000458)1.79129901
114Ankle clonus (HP:0011448)1.78188073
115Chronic hepatic failure (HP:0100626)1.77718243
116Growth hormone deficiency (HP:0000824)1.77710116
117Megalencephaly (HP:0001355)1.77701974
118Dialeptic seizures (HP:0011146)1.76646364
119Spastic tetraplegia (HP:0002510)1.76022541
120Abnormality of the aortic arch (HP:0012303)1.75989006
121Gait imbalance (HP:0002141)1.75758519
122Abnormality of ocular smooth pursuit (HP:0000617)1.75690558
123Peripheral hypomyelination (HP:0007182)1.75498557
124Impaired vibration sensation in the lower limbs (HP:0002166)1.75035639
125Narrow forehead (HP:0000341)1.74367442
126Hepatoblastoma (HP:0002884)1.74301109
127Amyotrophic lateral sclerosis (HP:0007354)1.73845338
128Septo-optic dysplasia (HP:0100842)1.73521670
129Hypercortisolism (HP:0001578)1.72884903
130Anomalous pulmonary venous return (HP:0010772)1.72816258
131Abnormality of salivation (HP:0100755)1.71961166
132Labial hypoplasia (HP:0000066)1.71907534
133Type II lissencephaly (HP:0007260)1.71016576
134Attenuation of retinal blood vessels (HP:0007843)1.70785823
135Decreased circulating renin level (HP:0003351)1.69914428
136Pancreatic cysts (HP:0001737)1.68708660
137Absent speech (HP:0001344)1.68640140
138Anophthalmia (HP:0000528)1.68563211
139Aqueductal stenosis (HP:0002410)1.68521239
140Protruding tongue (HP:0010808)1.68458819
141Hyperthyroidism (HP:0000836)1.68355466
142Optic nerve hypoplasia (HP:0000609)1.68062429
143Intellectual disability, severe (HP:0010864)1.67909004
144Inappropriate behavior (HP:0000719)1.67766524
145Deep palmar crease (HP:0006191)1.67069888
146Generalized tonic-clonic seizures (HP:0002069)1.67044818
147Rib fusion (HP:0000902)1.66873898
148Termporal pattern (HP:0011008)1.66780797
149Insidious onset (HP:0003587)1.66780797
150Restlessness (HP:0000711)1.66451867
151Pointed chin (HP:0000307)1.65960301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.30031298
2ERBB33.60684694
3NTRK33.52546663
4INSRR2.90506365
5NTRK22.30230641
6UHMK12.24851022
7MAP3K42.21953644
8PRPF4B1.99271332
9KSR11.98542776
10SIK21.93836342
11SIK31.92259471
12MAPK131.88816612
13MINK11.87385124
14MAP3K91.79352092
15HIPK21.77033865
16FRK1.72960407
17WNK31.64206554
18PAK61.63899646
19IRAK21.60430688
20MAP2K71.53862207
21DYRK21.50909196
22SGK2231.50303778
23SGK4941.50303778
24TNIK1.50081531
25PASK1.49312182
26CASK1.46423288
27BMPR21.39504603
28MAP3K21.38588767
29PRKD31.36948408
30BCR1.36105773
31PINK11.33273545
32TAOK21.23113401
33EPHB21.21176272
34EPHA31.18527033
35WNK41.17884595
36CDC42BPA1.17457331
37SGK21.15606699
38BRD41.13366379
39CAMKK21.13000054
40CDK51.11338771
41PKN11.07434230
42PAK31.05772933
43DYRK1B1.05701826
44CAMKK11.03870313
45PDGFRA1.02872299
46DYRK1A1.01231631
47CAMK1D1.00915388
48TYRO31.00843743
49SRPK10.99063621
50PNCK0.97969621
51ERBB20.97812499
52RET0.95123003
53NTRK10.94435817
54MAP4K20.94282684
55RPS6KA20.91480633
56ICK0.89684415
57CAMK1G0.88072179
58EPHA40.86730507
59IRAK10.84001673
60BMPR1B0.83699826
61MAP2K40.81865551
62CAMK10.80908315
63CSNK1G20.80039633
64PLK20.77850796
65PRKCG0.77476355
66KSR20.76891827
67TRIM280.76012112
68LIMK10.73992690
69MARK20.73574357
70ADRBK20.73073595
71FER0.71005532
72PTK20.69494588
73CDK30.68470306
74WNK10.66629402
75SGK30.66384523
76DAPK20.65756878
77PRKAA10.65210862
78PHKG20.64574666
79PHKG10.64574666
80CSNK1A1L0.63937383
81GRK10.62756858
82CSNK1G10.62653847
83YES10.60822498
84STK390.60228641
85MAPK150.59779428
86CSNK1G30.58989935
87PRKCZ0.58222630
88CDK180.57944323
89GRK50.57298912
90TNK20.55928687
91NEK60.55082844
92CSNK1E0.55072274
93CAMK2A0.54884865
94CDK190.54845421
95CDK140.54133978
96SGK10.52238136
97MAPK90.51692784
98CDK150.49723680
99ADRBK10.49575311
100OXSR10.48807302
101CSNK1D0.48528746
102AKT30.48226807
103PRKCH0.47858200
104CAMK2B0.47403923
105PRKACA0.46970028
106MAP3K60.46075132
107FGFR20.45756955
108ROCK10.45354069
109PTK60.44890216
110GSK3B0.44829699
111DYRK30.44538687
112CSNK1A10.44402515
113PRKG10.43498248
114STK380.43124697
115MAPK100.42852442
116RPS6KA30.42807658
117CDK11A0.42342175
118RIPK10.42242397
119PRKCE0.42148155
120MAPK80.41907157
121CAMK40.40285540
122STK38L0.40228406
123STK110.37560048
124BRSK10.37155118
125PRKDC0.35463264
126CAMK2G0.28339741
127PRKACB0.27478651

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.06403367
2Nicotine addiction_Homo sapiens_hsa050332.74518497
3Phototransduction_Homo sapiens_hsa047442.69553261
4Insulin secretion_Homo sapiens_hsa049112.59833062
5Synaptic vesicle cycle_Homo sapiens_hsa047212.54672790
6GABAergic synapse_Homo sapiens_hsa047272.35482451
7Type II diabetes mellitus_Homo sapiens_hsa049302.18523794
8Circadian entrainment_Homo sapiens_hsa047132.16565472
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16545847
10Glutamatergic synapse_Homo sapiens_hsa047242.10682324
11Morphine addiction_Homo sapiens_hsa050322.06165963
12Dopaminergic synapse_Homo sapiens_hsa047282.06005914
13Taste transduction_Homo sapiens_hsa047421.98967007
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96661733
15Cholinergic synapse_Homo sapiens_hsa047251.91484806
16Cocaine addiction_Homo sapiens_hsa050301.83379381
17Olfactory transduction_Homo sapiens_hsa047401.79698741
18Amphetamine addiction_Homo sapiens_hsa050311.79055230
19Long-term potentiation_Homo sapiens_hsa047201.78950032
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75170442
21Serotonergic synapse_Homo sapiens_hsa047261.72805710
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70454365
23Axon guidance_Homo sapiens_hsa043601.65523944
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41816432
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39991517
26Long-term depression_Homo sapiens_hsa047301.37588522
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36235321
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29935380
29Endometrial cancer_Homo sapiens_hsa052131.28111339
30Butanoate metabolism_Homo sapiens_hsa006501.25771466
31Gap junction_Homo sapiens_hsa045401.24261160
32Circadian rhythm_Homo sapiens_hsa047101.20644003
33GnRH signaling pathway_Homo sapiens_hsa049121.19572888
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12543674
35Estrogen signaling pathway_Homo sapiens_hsa049151.12339093
36Alcoholism_Homo sapiens_hsa050341.11641418
37ErbB signaling pathway_Homo sapiens_hsa040121.10856430
38Renin secretion_Homo sapiens_hsa049241.10509635
39Oxytocin signaling pathway_Homo sapiens_hsa049211.09869024
40Glioma_Homo sapiens_hsa052141.04373373
41Salivary secretion_Homo sapiens_hsa049701.04248390
42cAMP signaling pathway_Homo sapiens_hsa040241.01485464
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98732420
44mTOR signaling pathway_Homo sapiens_hsa041500.97756222
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97180089
46Gastric acid secretion_Homo sapiens_hsa049710.93375514
47Type I diabetes mellitus_Homo sapiens_hsa049400.92358855
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92102295
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91684581
50Vibrio cholerae infection_Homo sapiens_hsa051100.90656188
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89714789
52Oxidative phosphorylation_Homo sapiens_hsa001900.89637262
53Prolactin signaling pathway_Homo sapiens_hsa049170.89015081
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87644079
55Colorectal cancer_Homo sapiens_hsa052100.84904278
56Melanogenesis_Homo sapiens_hsa049160.83666191
57Steroid biosynthesis_Homo sapiens_hsa001000.83197036
58Pancreatic secretion_Homo sapiens_hsa049720.82577297
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80746774
60Hedgehog signaling pathway_Homo sapiens_hsa043400.80446046
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80240870
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80183281
63Parkinsons disease_Homo sapiens_hsa050120.80151544
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.79695565
65N-Glycan biosynthesis_Homo sapiens_hsa005100.79190092
66Dorso-ventral axis formation_Homo sapiens_hsa043200.77567163
67Ether lipid metabolism_Homo sapiens_hsa005650.77132069
68Calcium signaling pathway_Homo sapiens_hsa040200.76145664
69Renal cell carcinoma_Homo sapiens_hsa052110.75559410
70Choline metabolism in cancer_Homo sapiens_hsa052310.74830553
71Wnt signaling pathway_Homo sapiens_hsa043100.73325252
72Oocyte meiosis_Homo sapiens_hsa041140.73134311
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70559597
74Insulin signaling pathway_Homo sapiens_hsa049100.69416576
75Thyroid hormone synthesis_Homo sapiens_hsa049180.69190556
76Collecting duct acid secretion_Homo sapiens_hsa049660.68029073
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67453804
78Notch signaling pathway_Homo sapiens_hsa043300.67444401
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66712150
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66643854
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66359571
82Alzheimers disease_Homo sapiens_hsa050100.66224005
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66067061
84MAPK signaling pathway_Homo sapiens_hsa040100.65684116
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65301925
86Regulation of autophagy_Homo sapiens_hsa041400.65169829
87Linoleic acid metabolism_Homo sapiens_hsa005910.64015862
88Glucagon signaling pathway_Homo sapiens_hsa049220.63853786
89Ovarian steroidogenesis_Homo sapiens_hsa049130.63327963
90Inositol phosphate metabolism_Homo sapiens_hsa005620.62968069
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.60993159
92mRNA surveillance pathway_Homo sapiens_hsa030150.60796701
93Non-small cell lung cancer_Homo sapiens_hsa052230.60130351
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.56358530
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56301269
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55786933
97Basal cell carcinoma_Homo sapiens_hsa052170.55484675
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55155901
99VEGF signaling pathway_Homo sapiens_hsa043700.54571262
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54072273
101Bile secretion_Homo sapiens_hsa049760.54020891
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53263496
103Prion diseases_Homo sapiens_hsa050200.53227443
104Rap1 signaling pathway_Homo sapiens_hsa040150.53173927
105Fatty acid biosynthesis_Homo sapiens_hsa000610.51714592
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51396531
107Ras signaling pathway_Homo sapiens_hsa040140.51243906
108Protein export_Homo sapiens_hsa030600.50604054
109Chronic myeloid leukemia_Homo sapiens_hsa052200.50404621
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49226691
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.48889095
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47714174
113Huntingtons disease_Homo sapiens_hsa050160.46867596
114AMPK signaling pathway_Homo sapiens_hsa041520.46576848
115Cardiac muscle contraction_Homo sapiens_hsa042600.45389740
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45045437
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44883510
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44086011
119Lysine degradation_Homo sapiens_hsa003100.43177847
120Dilated cardiomyopathy_Homo sapiens_hsa054140.42816853
121Hippo signaling pathway_Homo sapiens_hsa043900.41619628

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