MYT1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.66976153
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58552515
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.52560741
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40559442
5neuron cell-cell adhesion (GO:0007158)5.19998525
6synaptic vesicle exocytosis (GO:0016079)5.10414354
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.04824050
8locomotory exploration behavior (GO:0035641)5.01218129
9regulation of glutamate receptor signaling pathway (GO:1900449)4.98794899
10protein localization to synapse (GO:0035418)4.97221510
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.97039636
12synaptic vesicle maturation (GO:0016188)4.69892627
13glutamate receptor signaling pathway (GO:0007215)4.68295542
14regulation of synaptic vesicle exocytosis (GO:2000300)4.66431676
15glutamate secretion (GO:0014047)4.57546545
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.52720318
17synaptic transmission, glutamatergic (GO:0035249)4.37233628
18exploration behavior (GO:0035640)4.34893980
19neuronal action potential propagation (GO:0019227)4.34152777
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.31461513
21neuron-neuron synaptic transmission (GO:0007270)4.29292830
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.25431712
23neurotransmitter-gated ion channel clustering (GO:0072578)4.25400396
24neuron recognition (GO:0008038)4.23573727
25pyrimidine nucleobase catabolic process (GO:0006208)4.21188810
26regulation of synapse structural plasticity (GO:0051823)4.20708331
27regulation of synaptic vesicle transport (GO:1902803)4.19649933
28regulation of neuronal synaptic plasticity (GO:0048168)4.15226535
29layer formation in cerebral cortex (GO:0021819)4.06244864
30dendritic spine morphogenesis (GO:0060997)4.05504726
31neurotransmitter secretion (GO:0007269)4.03447785
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.96148700
33positive regulation of synapse maturation (GO:0090129)3.90039325
34presynaptic membrane assembly (GO:0097105)3.89928704
35long-term memory (GO:0007616)3.84774684
36gamma-aminobutyric acid transport (GO:0015812)3.82297200
37axonal fasciculation (GO:0007413)3.82164154
38postsynaptic membrane organization (GO:0001941)3.79168834
39regulation of postsynaptic membrane potential (GO:0060078)3.78706492
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.76058435
41positive regulation of membrane potential (GO:0045838)3.75785225
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73538864
43regulation of dendritic spine morphogenesis (GO:0061001)3.73028965
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.72972462
45transmission of nerve impulse (GO:0019226)3.70160030
46nucleobase catabolic process (GO:0046113)3.66983137
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64654206
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63441790
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.60688154
50presynaptic membrane organization (GO:0097090)3.58989403
51regulation of synaptic plasticity (GO:0048167)3.56227243
52long-term synaptic potentiation (GO:0060291)3.54045262
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.51040261
54response to histamine (GO:0034776)3.49021173
55behavioral response to nicotine (GO:0035095)3.48409715
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44000240
57proline transport (GO:0015824)3.41066059
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.40162821
59establishment of mitochondrion localization (GO:0051654)3.39492553
60behavioral fear response (GO:0001662)3.38350364
61behavioral defense response (GO:0002209)3.38350364
62synaptic vesicle endocytosis (GO:0048488)3.36405962
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.35675228
64negative regulation of dendrite development (GO:2000171)3.34047593
65neurotransmitter transport (GO:0006836)3.33967688
66positive regulation of neurotransmitter secretion (GO:0001956)3.32077567
67regulation of neurotransmitter secretion (GO:0046928)3.29818826
68serotonin metabolic process (GO:0042428)3.29176165
69mechanosensory behavior (GO:0007638)3.28502397
70auditory behavior (GO:0031223)3.27060006
71prepulse inhibition (GO:0060134)3.25200328
72membrane depolarization (GO:0051899)3.25101276
73adult walking behavior (GO:0007628)3.24962559
74regulation of vesicle fusion (GO:0031338)3.24796443
75synapse assembly (GO:0007416)3.24740463
76learning (GO:0007612)3.23754421
77behavioral response to cocaine (GO:0048148)3.23017846
78regulation of dendritic spine development (GO:0060998)3.22470041
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.21127678
80neuronal action potential (GO:0019228)3.20402024
81regulation of female receptivity (GO:0045924)3.18852295
82positive regulation of neurotransmitter transport (GO:0051590)3.18392705
83fear response (GO:0042596)3.18314601
84positive regulation of synapse assembly (GO:0051965)3.18147763
85dendrite morphogenesis (GO:0048813)3.17982868
86neuronal ion channel clustering (GO:0045161)3.17223565
87regulation of synapse maturation (GO:0090128)3.17163781
88regulation of glutamate secretion (GO:0014048)3.16846650
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16157122
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.15614660
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14209311
92startle response (GO:0001964)3.13263881
93positive regulation of dendritic spine development (GO:0060999)3.12480854
94central nervous system neuron axonogenesis (GO:0021955)3.11573470
95cerebellar Purkinje cell differentiation (GO:0021702)3.10466659
96activation of protein kinase A activity (GO:0034199)3.10287725
97membrane depolarization during action potential (GO:0086010)3.10171533
98cell migration in hindbrain (GO:0021535)3.08797466
99response to auditory stimulus (GO:0010996)3.08248100
100membrane hyperpolarization (GO:0060081)3.07870516
101neuromuscular process controlling balance (GO:0050885)3.05668487
102regulation of neurotransmitter transport (GO:0051588)3.05658415
103regulation of neurotransmitter levels (GO:0001505)3.05425655
104intraspecies interaction between organisms (GO:0051703)3.03179961
105social behavior (GO:0035176)3.03179961
106cellular potassium ion homeostasis (GO:0030007)3.02713849
107negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02708444
108striatum development (GO:0021756)3.02021232
109innervation (GO:0060384)3.01773299
110cerebellar granule cell differentiation (GO:0021707)3.00989034
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00641511
112central nervous system projection neuron axonogenesis (GO:0021952)2.99766813
113female mating behavior (GO:0060180)2.99758716
114cerebral cortex radially oriented cell migration (GO:0021799)2.98761802
115dendritic spine organization (GO:0097061)2.98092492
116primary amino compound metabolic process (GO:1901160)2.97636838
117regulation of voltage-gated calcium channel activity (GO:1901385)2.93841528
118synaptic transmission (GO:0007268)2.92457251
119neuromuscular synaptic transmission (GO:0007274)2.90920655
120adult behavior (GO:0030534)2.89222789
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86382653
122mitochondrion transport along microtubule (GO:0047497)2.86382653
123regulation of synapse assembly (GO:0051963)2.85228142
124glycosphingolipid biosynthetic process (GO:0006688)2.79954762
125axon ensheathment in central nervous system (GO:0032291)2.77964137
126central nervous system myelination (GO:0022010)2.77964137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.47538299
2GBX2_23144817_ChIP-Seq_PC3_Human3.96647009
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12211289
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11633745
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00264399
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.70478123
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64400665
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64400665
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63225564
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.60726972
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59983295
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49074172
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46134281
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41619781
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40101829
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39891397
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.33036285
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.20923929
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19963647
20* DROSHA_22980978_ChIP-Seq_HELA_Human2.19729529
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.14913534
22TAF15_26573619_Chip-Seq_HEK293_Human2.13967395
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12402024
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11071375
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04568018
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98323752
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92823050
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92805599
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91704390
30* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91410429
31AR_21572438_ChIP-Seq_LNCaP_Human1.87530492
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82631294
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75430850
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.73495288
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65114191
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64131547
37P300_19829295_ChIP-Seq_ESCs_Human1.61462308
38* VDR_22108803_ChIP-Seq_LS180_Human1.58187202
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54779179
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52528545
41ZNF274_21170338_ChIP-Seq_K562_Hela1.50520441
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50194859
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.49387556
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47759714
45IGF1R_20145208_ChIP-Seq_DFB_Human1.46844381
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44476982
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.44289038
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40983858
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39691590
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37111147
51* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35796184
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35601932
53AR_25329375_ChIP-Seq_VCAP_Human1.33316862
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32786002
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32142253
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31347762
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.30675319
58RNF2_27304074_Chip-Seq_NSC_Mouse1.28900102
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.26977067
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.26810596
61* STAT3_23295773_ChIP-Seq_U87_Human1.26355806
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.25408509
63EWS_26573619_Chip-Seq_HEK293_Human1.22485496
64* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22481481
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21894600
66FUS_26573619_Chip-Seq_HEK293_Human1.21319905
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21151070
68* AR_19668381_ChIP-Seq_PC3_Human1.16514794
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.15734679
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14869319
71* TCF4_23295773_ChIP-Seq_U87_Human1.14089026
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12637355
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12327591
74AHR_22903824_ChIP-Seq_MCF-7_Human1.10393970
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.10306174
76CBP_20019798_ChIP-Seq_JUKART_Human1.10020826
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10020826
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.09993461
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09542289
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09193749
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08616093
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.08024308
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05851379
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05811852
85* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05655747
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04987741
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04113261
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04113261
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03970078
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.03479513
91KDM2B_26808549_Chip-Seq_REH_Human1.03141801
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02959347
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01918665
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01403447
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01193651
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01130250
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01052108
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00994571
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00822809
100ER_23166858_ChIP-Seq_MCF-7_Human0.99936230
101* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99669918
102NANOG_18555785_Chip-Seq_ESCs_Mouse0.98655634
103TP53_18474530_ChIP-ChIP_U2OS_Human0.97285231
104* JUN_21703547_ChIP-Seq_K562_Human0.96819786
105TCF4_22108803_ChIP-Seq_LS180_Human0.95762680
106TP53_16413492_ChIP-PET_HCT116_Human0.95367316
107* SOX9_26525672_Chip-Seq_HEART_Mouse0.94352447
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94126730
109BCAT_22108803_ChIP-Seq_LS180_Human0.92999922
110* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91620249
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91389973
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91146249
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90004300
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.88650992
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88055121
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.86866066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.04512659
2MP0003880_abnormal_central_pattern5.21162762
3MP0003635_abnormal_synaptic_transmissio4.11936073
4MP0004270_analgesia3.70904794
5MP0009745_abnormal_behavioral_response3.46228258
6MP0002063_abnormal_learning/memory/cond3.41827984
7MP0002064_seizures3.08135719
8MP0002822_catalepsy3.06683291
9MP0001968_abnormal_touch/_nociception3.06304092
10MP0002572_abnormal_emotion/affect_behav2.89742780
11MP0009046_muscle_twitch2.85298451
12MP0005423_abnormal_somatic_nervous2.78783301
13MP0002734_abnormal_mechanical_nocicepti2.64785449
14MP0001486_abnormal_startle_reflex2.56737689
15MP0002272_abnormal_nervous_system2.56105659
16MP0002736_abnormal_nociception_after2.45425591
17MP0002735_abnormal_chemical_nociception2.40462785
18MP0001501_abnormal_sleep_pattern2.27139805
19MP0001440_abnormal_grooming_behavior2.26242667
20MP0006276_abnormal_autonomic_nervous2.08381871
21MP0000778_abnormal_nervous_system2.07486048
22MP0002733_abnormal_thermal_nociception2.04535390
23MP0002067_abnormal_sensory_capabilities2.02728534
24MP0002184_abnormal_innervation1.96405627
25MP0001970_abnormal_pain_threshold1.95852220
26MP0001984_abnormal_olfaction1.93206088
27MP0002557_abnormal_social/conspecific_i1.84594093
28MP0005386_behavior/neurological_phenoty1.81369205
29MP0004924_abnormal_behavior1.81369205
30MP0001529_abnormal_vocalization1.77841785
31MP0009780_abnormal_chondrocyte_physiolo1.72039004
32MP0008877_abnormal_DNA_methylation1.70124662
33MP0003787_abnormal_imprinting1.70107583
34MP0005646_abnormal_pituitary_gland1.69793276
35MP0005645_abnormal_hypothalamus_physiol1.68664604
36MP0002909_abnormal_adrenal_gland1.68577062
37MP0004811_abnormal_neuron_physiology1.65816390
38MP0008569_lethality_at_weaning1.65489900
39MP0001188_hyperpigmentation1.65488601
40MP0003329_amyloid_beta_deposits1.57372604
41MP0003879_abnormal_hair_cell1.53663864
42MP0000955_abnormal_spinal_cord1.48311373
43MP0004858_abnormal_nervous_system1.43255146
44MP0002882_abnormal_neuron_morphology1.42308806
45MP0002066_abnormal_motor_capabilities/c1.40694556
46MP0001905_abnormal_dopamine_level1.30225221
47MP0003122_maternal_imprinting1.26957317
48MP0001502_abnormal_circadian_rhythm1.26400054
49MP0004885_abnormal_endolymph1.26365241
50MP0004142_abnormal_muscle_tone1.26086992
51MP0010386_abnormal_urinary_bladder1.18600299
52MP0003633_abnormal_nervous_system1.14762110
53MP0002152_abnormal_brain_morphology1.14634864
54MP0005394_taste/olfaction_phenotype1.11150665
55MP0005499_abnormal_olfactory_system1.11150665
56MP0004147_increased_porphyrin_level1.07198182
57MP0001986_abnormal_taste_sensitivity1.06263156
58MP0004133_heterotaxia1.01624932
59MP0005409_darkened_coat_color1.01495176
60MP0002837_dystrophic_cardiac_calcinosis1.01073502
61MP0004043_abnormal_pH_regulation0.99788967
62MP0004742_abnormal_vestibular_system0.99575999
63MP0003631_nervous_system_phenotype0.98979428
64MP0002069_abnormal_eating/drinking_beha0.97890893
65MP0005551_abnormal_eye_electrophysiolog0.97833503
66MP0008872_abnormal_physiological_respon0.92081696
67MP0000631_abnormal_neuroendocrine_gland0.91448454
68MP0002229_neurodegeneration0.91165870
69MP0002876_abnormal_thyroid_physiology0.90823674
70MP0000751_myopathy0.90377080
71MP0003123_paternal_imprinting0.89392527
72MP0004085_abnormal_heartbeat0.88606326
73MP0004145_abnormal_muscle_electrophysio0.88459457
74MP0001963_abnormal_hearing_physiology0.87732868
75MP0005253_abnormal_eye_physiology0.87001716
76MP0002751_abnormal_autonomic_nervous0.85109095
77MP0002234_abnormal_pharynx_morphology0.84923625
78MP0003195_calcinosis0.84330069
79MP0006292_abnormal_olfactory_placode0.83029658
80MP0002752_abnormal_somatic_nervous0.82920284
81MP0008874_decreased_physiological_sensi0.82771736
82MP0001177_atelectasis0.80203239
83MP0005535_abnormal_body_temperature0.78825098
84MP0000569_abnormal_digit_pigmentation0.76682512
85MP0002638_abnormal_pupillary_reflex0.74743807
86MP0003119_abnormal_digestive_system0.73983213
87MP0000013_abnormal_adipose_tissue0.71576928
88MP0003137_abnormal_impulse_conducting0.70974103
89MP0003634_abnormal_glial_cell0.69554513
90MP0000920_abnormal_myelination0.68003042
91MP0001485_abnormal_pinna_reflex0.67945614
92MP0001664_abnormal_digestion0.66021863
93MP0003861_abnormal_nervous_system0.64860295
94MP0004215_abnormal_myocardial_fiber0.64593314
95MP0003632_abnormal_nervous_system0.64422447
96MP0000026_abnormal_inner_ear0.62897830
97MP0003690_abnormal_glial_cell0.62606775
98MP0003890_abnormal_embryonic-extraembry0.62552990
99MP0005195_abnormal_posterior_eye0.62460212
100MP0003938_abnormal_ear_development0.62448901
101MP0003283_abnormal_digestive_organ0.62175954
102MP0004484_altered_response_of0.61669388
103MP0000604_amyloidosis0.60736870
104MP0008961_abnormal_basal_metabolism0.60720334
105MP0002102_abnormal_ear_morphology0.58519224
106MP0003121_genomic_imprinting0.57104052
107MP0001943_abnormal_respiration0.54244760
108MP0006072_abnormal_retinal_apoptosis0.54051587
109MP0005187_abnormal_penis_morphology0.53237143
110MP0002082_postnatal_lethality0.53142872
111MP0010770_preweaning_lethality0.53142872
112MP0010769_abnormal_survival0.52489368
113MP0008789_abnormal_olfactory_epithelium0.51922222
114MP0002090_abnormal_vision0.51084082
115MP0010768_mortality/aging0.49605181
116MP0003956_abnormal_body_size0.49297797

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.06209456
2Myokymia (HP:0002411)6.24219228
3Focal seizures (HP:0007359)5.89009068
4Epileptic encephalopathy (HP:0200134)5.20615313
5Atonic seizures (HP:0010819)4.88034778
6Visual hallucinations (HP:0002367)4.87768642
7Febrile seizures (HP:0002373)4.79827330
8Hyperventilation (HP:0002883)4.40093588
9Absence seizures (HP:0002121)4.30749084
10Progressive cerebellar ataxia (HP:0002073)4.13414574
11Broad-based gait (HP:0002136)4.01625244
12Dialeptic seizures (HP:0011146)3.99141863
13Generalized tonic-clonic seizures (HP:0002069)3.93554057
14Poor eye contact (HP:0000817)3.47203976
15Amblyopia (HP:0000646)3.43598816
16Supranuclear gaze palsy (HP:0000605)3.32561544
17Excessive salivation (HP:0003781)3.27309960
18Drooling (HP:0002307)3.27309960
19Gaze-evoked nystagmus (HP:0000640)3.23531183
20Action tremor (HP:0002345)3.19682755
21Impaired vibration sensation in the lower limbs (HP:0002166)3.08287113
22Abnormal social behavior (HP:0012433)3.06015739
23Impaired social interactions (HP:0000735)3.06015739
24Truncal ataxia (HP:0002078)3.02570455
25Depression (HP:0000716)2.94066011
26Anxiety (HP:0000739)2.89397766
27Dysdiadochokinesis (HP:0002075)2.88200617
28Ankle clonus (HP:0011448)2.87127771
29Abnormal eating behavior (HP:0100738)2.83098769
30Epileptiform EEG discharges (HP:0011182)2.82030986
31Mutism (HP:0002300)2.80437731
32Absent speech (HP:0001344)2.76467034
33Dysmetria (HP:0001310)2.74632791
34Urinary bladder sphincter dysfunction (HP:0002839)2.72425855
35Protruding tongue (HP:0010808)2.69495816
36Progressive inability to walk (HP:0002505)2.66940709
37Cerebral inclusion bodies (HP:0100314)2.65772268
38Hemiparesis (HP:0001269)2.65510164
39Impaired smooth pursuit (HP:0007772)2.63465125
40EEG with generalized epileptiform discharges (HP:0011198)2.63441212
41Polyphagia (HP:0002591)2.56006611
42Abnormality of the lower motor neuron (HP:0002366)2.55859745
43Genetic anticipation (HP:0003743)2.55631990
44Stereotypic behavior (HP:0000733)2.55596163
45Neurofibrillary tangles (HP:0002185)2.54923868
46Limb dystonia (HP:0002451)2.53296909
47Inability to walk (HP:0002540)2.48837625
48Abnormality of binocular vision (HP:0011514)2.48671387
49Diplopia (HP:0000651)2.48671387
50Termporal pattern (HP:0011008)2.46230495
51Insidious onset (HP:0003587)2.46230495
52Scanning speech (HP:0002168)2.46080058
53Hypsarrhythmia (HP:0002521)2.44832306
54Type II lissencephaly (HP:0007260)2.41953038
55Urinary urgency (HP:0000012)2.41012519
56Torticollis (HP:0000473)2.39417656
57Amyotrophic lateral sclerosis (HP:0007354)2.38923256
58Lissencephaly (HP:0001339)2.35842504
59Abnormality of the corticospinal tract (HP:0002492)2.35782432
60Fetal akinesia sequence (HP:0001989)2.35433052
61Pancreatic fibrosis (HP:0100732)2.34662798
62Abnormality of the labia minora (HP:0012880)2.33993285
63Molar tooth sign on MRI (HP:0002419)2.33351165
64Abnormality of midbrain morphology (HP:0002418)2.33351165
65Nephronophthisis (HP:0000090)2.32526782
66Papilledema (HP:0001085)2.32463024
67Postural instability (HP:0002172)2.31801208
68Pancreatic cysts (HP:0001737)2.29970133
69Spastic gait (HP:0002064)2.29051488
70Gait imbalance (HP:0002141)2.27040013
71Focal dystonia (HP:0004373)2.26069090
72Abnormality of salivation (HP:0100755)2.22642871
73Blue irides (HP:0000635)2.22631287
74Bradykinesia (HP:0002067)2.20528740
75Retinal dysplasia (HP:0007973)2.20331314
76Abnormality of ocular smooth pursuit (HP:0000617)2.19889920
77Pachygyria (HP:0001302)2.17682756
78Widely spaced teeth (HP:0000687)2.14053546
79Inappropriate behavior (HP:0000719)2.13662874
80Status epilepticus (HP:0002133)2.11019020
81Impaired vibratory sensation (HP:0002495)2.06342935
82True hermaphroditism (HP:0010459)2.06210711
83Congenital stationary night blindness (HP:0007642)2.04461487
84Fair hair (HP:0002286)2.03594060
85Intellectual disability, severe (HP:0010864)2.03091413
86Agitation (HP:0000713)2.02256696
87Pheochromocytoma (HP:0002666)2.01973057
88Hemiplegia (HP:0002301)2.01716861
89Craniofacial dystonia (HP:0012179)2.00505486
90Generalized myoclonic seizures (HP:0002123)1.98873121
91Abnormality of the renal medulla (HP:0100957)1.97791625
92Dysmetric saccades (HP:0000641)1.96708850
93Spastic tetraplegia (HP:0002510)1.95232092
94Exotropia (HP:0000577)1.94474678
95Lower limb muscle weakness (HP:0007340)1.92171946
96Prolonged QT interval (HP:0001657)1.91644543
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90300074
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.90300074
99Hyperthyroidism (HP:0000836)1.89403926
100Incomplete penetrance (HP:0003829)1.89001868
101Gait ataxia (HP:0002066)1.88965434
102Specific learning disability (HP:0001328)1.87388404
103Optic nerve hypoplasia (HP:0000609)1.86519910
104Generalized hypopigmentation of hair (HP:0011358)1.85159714
105Chronic hepatic failure (HP:0100626)1.84621420
106Hypoplasia of the corpus callosum (HP:0002079)1.84225271
107Morphological abnormality of the pyramidal tract (HP:0002062)1.83667473
108Intention tremor (HP:0002080)1.83093936
109Akinesia (HP:0002304)1.82833705
110Megalencephaly (HP:0001355)1.81697447
111Psychosis (HP:0000709)1.81593321
112Failure to thrive in infancy (HP:0001531)1.81418886
113Hypoplasia of the brainstem (HP:0002365)1.80948249
114Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80948249
115Neuronal loss in central nervous system (HP:0002529)1.80593851
116Autism (HP:0000717)1.79140939
117Hepatoblastoma (HP:0002884)1.78998051
118Delusions (HP:0000746)1.77587862
119Spastic tetraparesis (HP:0001285)1.77483767
120Thickened helices (HP:0000391)1.77472207
121Dyskinesia (HP:0100660)1.77304903
122Genital tract atresia (HP:0001827)1.77244254
123Sleep apnea (HP:0010535)1.77230677
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.76102749
125Absent/shortened dynein arms (HP:0200106)1.76102749
126Congenital primary aphakia (HP:0007707)1.75807529
127Neuroendocrine neoplasm (HP:0100634)1.74444835
128Medial flaring of the eyebrow (HP:0010747)1.74084081
129Cerebral hypomyelination (HP:0006808)1.74044609
130Esotropia (HP:0000565)1.73354315
131Gastroesophageal reflux (HP:0002020)1.72521070
132Hypothermia (HP:0002045)1.71890088
133Nephrogenic diabetes insipidus (HP:0009806)1.71769553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80288632
2NTRK34.47016526
3MARK13.71814710
4MAP3K93.26858451
5FRK3.14261792
6MAP3K43.13450509
7CASK2.85822322
8MAP2K72.81009925
9MINK12.53989229
10RIPK42.42378771
11DAPK22.27225935
12MAP3K122.15510785
13NTRK22.07738331
14TNIK1.92675931
15MAP2K41.90850909
16PNCK1.82571860
17SIK21.80564266
18KSR11.75223150
19PAK61.74388381
20MAPK131.70964556
21PLK21.69870586
22DAPK11.61181750
23KSR21.59671897
24CDK51.52722573
25NTRK11.46617221
26PRPF4B1.45969629
27MAP4K21.45858425
28CAMKK11.43709919
29BMPR21.36337695
30PRKD31.32100588
31CDK191.32039645
32GRK51.31586220
33BMPR1B1.27889847
34ARAF1.26741455
35ADRBK21.25013775
36FES1.24938300
37PRKCG1.22043819
38UHMK11.08412809
39CAMK2A1.07358101
40CAMKK20.99431306
41CAMK2B0.98067881
42WNK40.92290245
43SGK2230.92202838
44SGK4940.92202838
45MAP3K20.91933362
46EPHA30.88989503
47PHKG10.88844595
48PHKG20.88844595
49SGK20.88548202
50INSRR0.87725118
51FGFR20.87044012
52DYRK1A0.86670954
53CDK180.86480349
54STK380.85100841
55ACVR1B0.84339193
56MAP3K130.84332387
57PTK2B0.82329266
58CDK150.82064696
59GRK10.81635112
60CDK140.80810679
61RAF10.76827899
62TYRO30.76142924
63OXSR10.75481662
64NME10.75023704
65CAMK10.74573021
66STK110.74352729
67MARK20.74239078
68SGK10.72597331
69AKT30.72300793
70LATS20.72089297
71WNK30.71270976
72CDK11A0.71256429
73CSNK1G20.68839443
74STK390.68264587
75CCNB10.68154437
76ERBB30.66182246
77SIK30.65884435
78FGR0.65573848
79CSNK1G30.63998824
80PRKCE0.63878919
81PAK30.60682645
82MKNK20.59903054
83SGK30.58720296
84CSNK1A1L0.58694262
85CSNK1G10.57857408
86PRKCZ0.57130983
87MAP3K60.57054922
88RET0.56911804
89PRKCH0.55039960
90PINK10.53292058
91TRIM280.52095538
92BCR0.51036582
93CAMK2D0.50481828
94CSNK1D0.50335573
95BRAF0.49167189
96TNK20.46670579
97GRK70.46577588
98PRKG10.46397160
99TAOK10.46208629
100ADRBK10.45277241
101CSNK1A10.44761051
102FER0.43176622
103RPS6KA30.42710011
104PDPK10.42698199
105TLK10.42568018
106MAP2K10.41309671
107CAMK1D0.41084250
108PDK10.40820276
109CAMK1G0.40600369
110FYN0.40546132
111MAP2K60.38066887
112MAPK100.38041638
113CAMK2G0.37952654
114CDC42BPA0.37583792
115PRKAA10.35979237
116MAPK120.35456482
117DYRK20.35301691
118RPS6KA20.35153485
119MAP3K10.34974928
120CSNK1E0.34827563
121PKN10.34675243
122PRKCB0.34292016
123PRKCA0.33456035
124CAMK40.33137605
125PRKACA0.32725596
126WNK10.32486689
127MAPK80.30216036
128PRKACB0.29107465
129GSK3B0.26020606

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12258542
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16525480
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88569309
4Olfactory transduction_Homo sapiens_hsa047402.86640744
5Long-term potentiation_Homo sapiens_hsa047202.78955163
6Circadian entrainment_Homo sapiens_hsa047132.78047438
7GABAergic synapse_Homo sapiens_hsa047272.74534685
8Glutamatergic synapse_Homo sapiens_hsa047242.69969761
9Morphine addiction_Homo sapiens_hsa050322.66513824
10Amphetamine addiction_Homo sapiens_hsa050312.58075346
11Dopaminergic synapse_Homo sapiens_hsa047282.32478477
12Salivary secretion_Homo sapiens_hsa049702.15057745
13Taste transduction_Homo sapiens_hsa047422.08156850
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03144638
15Insulin secretion_Homo sapiens_hsa049111.97396766
16Cholinergic synapse_Homo sapiens_hsa047251.92699278
17Serotonergic synapse_Homo sapiens_hsa047261.90291913
18Renin secretion_Homo sapiens_hsa049241.84332989
19Long-term depression_Homo sapiens_hsa047301.84157797
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77443418
21Cocaine addiction_Homo sapiens_hsa050301.76203280
22Gastric acid secretion_Homo sapiens_hsa049711.74673310
23Collecting duct acid secretion_Homo sapiens_hsa049661.71759470
24Calcium signaling pathway_Homo sapiens_hsa040201.69497330
25Oxytocin signaling pathway_Homo sapiens_hsa049211.68352455
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55060188
27GnRH signaling pathway_Homo sapiens_hsa049121.42710289
28Gap junction_Homo sapiens_hsa045401.41350400
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35056935
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31777573
31Axon guidance_Homo sapiens_hsa043601.30027866
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29452174
33cAMP signaling pathway_Homo sapiens_hsa040241.26997084
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19853084
35Butanoate metabolism_Homo sapiens_hsa006501.19535820
36Phototransduction_Homo sapiens_hsa047441.18800387
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11570509
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10647271
39Type II diabetes mellitus_Homo sapiens_hsa049301.09764704
40Estrogen signaling pathway_Homo sapiens_hsa049151.09521193
41Vibrio cholerae infection_Homo sapiens_hsa051101.07139705
42Glioma_Homo sapiens_hsa052141.04541330
43Cardiac muscle contraction_Homo sapiens_hsa042601.04053641
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03948564
45ErbB signaling pathway_Homo sapiens_hsa040121.02465519
46Melanogenesis_Homo sapiens_hsa049161.01933814
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98537657
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.94175400
49Oocyte meiosis_Homo sapiens_hsa041140.82537637
50Pancreatic secretion_Homo sapiens_hsa049720.81006517
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79975257
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78877296
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.78862329
54Ether lipid metabolism_Homo sapiens_hsa005650.78436998
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78106901
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77811705
57Nitrogen metabolism_Homo sapiens_hsa009100.76722782
58Alzheimers disease_Homo sapiens_hsa050100.75059967
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74776643
60Dorso-ventral axis formation_Homo sapiens_hsa043200.74491529
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.73683577
62Choline metabolism in cancer_Homo sapiens_hsa052310.71505369
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71432968
64MAPK signaling pathway_Homo sapiens_hsa040100.70787378
65Linoleic acid metabolism_Homo sapiens_hsa005910.70208496
66Thyroid hormone synthesis_Homo sapiens_hsa049180.65448396
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63637673
68Dilated cardiomyopathy_Homo sapiens_hsa054140.62374743
69Ras signaling pathway_Homo sapiens_hsa040140.60786424
70Oxidative phosphorylation_Homo sapiens_hsa001900.60561007
71Regulation of autophagy_Homo sapiens_hsa041400.59855109
72Bile secretion_Homo sapiens_hsa049760.59588177
73Alcoholism_Homo sapiens_hsa050340.58953913
74VEGF signaling pathway_Homo sapiens_hsa043700.58392527
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56663041
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55107885
77Glucagon signaling pathway_Homo sapiens_hsa049220.54796521
78Type I diabetes mellitus_Homo sapiens_hsa049400.54434760
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53745369
80Rap1 signaling pathway_Homo sapiens_hsa040150.53588540
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52699526
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.51758089
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50868764
84African trypanosomiasis_Homo sapiens_hsa051430.47334460
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.47201381
86Wnt signaling pathway_Homo sapiens_hsa043100.46989327
87Circadian rhythm_Homo sapiens_hsa047100.45893007
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44938623
89Inositol phosphate metabolism_Homo sapiens_hsa005620.44929024
90ABC transporters_Homo sapiens_hsa020100.44245104
91Fatty acid biosynthesis_Homo sapiens_hsa000610.42051494
92Parkinsons disease_Homo sapiens_hsa050120.42018009
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41522006
94Tryptophan metabolism_Homo sapiens_hsa003800.41384276
95Endometrial cancer_Homo sapiens_hsa052130.41280978
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39847524
97Renal cell carcinoma_Homo sapiens_hsa052110.39583563
98Prion diseases_Homo sapiens_hsa050200.37707234
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37158762
100Histidine metabolism_Homo sapiens_hsa003400.36794414
101Mineral absorption_Homo sapiens_hsa049780.36766012
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36750401
103Non-small cell lung cancer_Homo sapiens_hsa052230.36638651
104beta-Alanine metabolism_Homo sapiens_hsa004100.36125781
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35267334
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34184205
107mTOR signaling pathway_Homo sapiens_hsa041500.33605542
108Ovarian steroidogenesis_Homo sapiens_hsa049130.33022769
109Endocytosis_Homo sapiens_hsa041440.31226245
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30945103
111Insulin signaling pathway_Homo sapiens_hsa049100.30883985
112Selenocompound metabolism_Homo sapiens_hsa004500.30245978
113Huntingtons disease_Homo sapiens_hsa050160.29775017
114Vitamin B6 metabolism_Homo sapiens_hsa007500.29291985
115Colorectal cancer_Homo sapiens_hsa052100.27733336
116Chemokine signaling pathway_Homo sapiens_hsa040620.27618969
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26803593
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26323695
119Rheumatoid arthritis_Homo sapiens_hsa053230.25561836
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24739579
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24476245
122Hippo signaling pathway_Homo sapiens_hsa043900.24039582
123Peroxisome_Homo sapiens_hsa041460.21901196

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