MZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)5.85152042
2negative regulation of erythrocyte differentiation (GO:0045647)5.20838480
3cellular response to ATP (GO:0071318)4.58253613
4DNA integration (GO:0015074)4.50927396
5semaphorin-plexin signaling pathway (GO:0071526)4.40547103
6proline biosynthetic process (GO:0006561)4.27658899
7regulation of ARF GTPase activity (GO:0032312)4.21958121
8replication fork processing (GO:0031297)4.15096004
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.15084653
10DNA strand renaturation (GO:0000733)4.12272978
11positive regulation of protein kinase C signaling (GO:0090037)4.11655346
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.09810005
13histone H4 deacetylation (GO:0070933)4.04419709
14histone H3 deacetylation (GO:0070932)3.96549153
15regulation of hydrogen peroxide metabolic process (GO:0010310)3.90501397
16auditory receptor cell stereocilium organization (GO:0060088)3.89593182
17positive regulation of dendritic spine morphogenesis (GO:0061003)3.83404376
18transcription from mitochondrial promoter (GO:0006390)3.80970162
19negative regulation of cell size (GO:0045792)3.79406858
20presynaptic membrane assembly (GO:0097105)3.75005945
21keratinocyte development (GO:0003334)3.73695677
22proline metabolic process (GO:0006560)3.69404998
23regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.68365383
24epithelial cilium movement (GO:0003351)3.62189871
25neuron cell-cell adhesion (GO:0007158)3.62120891
26positive regulation of histone deacetylation (GO:0031065)3.57582256
27retina layer formation (GO:0010842)3.56353726
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53493572
29negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.51198642
30positive regulation of CREB transcription factor activity (GO:0032793)3.49714794
31inner ear receptor stereocilium organization (GO:0060122)3.44083347
32face development (GO:0060324)3.41705000
33histone H3-K4 trimethylation (GO:0080182)3.41584177
34cilium or flagellum-dependent cell motility (GO:0001539)3.39983965
35cilium movement (GO:0003341)3.39932021
36poly(A)+ mRNA export from nucleus (GO:0016973)3.39823560
37phosphatidylglycerol biosynthetic process (GO:0006655)3.38930051
38axonemal dynein complex assembly (GO:0070286)3.38565799
39GDP-mannose metabolic process (GO:0019673)3.34698187
40synaptic vesicle endocytosis (GO:0048488)3.34511303
41presynaptic membrane organization (GO:0097090)3.32235249
42negative regulation of heart rate (GO:0010459)3.31365058
43regulation of respiratory system process (GO:0044065)3.28808845
44positive regulation of developmental pigmentation (GO:0048087)3.28721087
45regulation of timing of cell differentiation (GO:0048505)3.27858220
46positive regulation of protein homooligomerization (GO:0032464)3.26767246
47oxidative demethylation (GO:0070989)3.24744547
48regulation of ARF protein signal transduction (GO:0032012)3.24581715
49cellular response to virus (GO:0098586)3.24432531
50cell-cell junction maintenance (GO:0045217)3.22417334
51limb bud formation (GO:0060174)3.19795285
52DNA ligation (GO:0006266)3.18355119
53negative regulation of Ras GTPase activity (GO:0034261)3.15380961
54endothelial cell chemotaxis (GO:0035767)3.14211644
55righting reflex (GO:0060013)3.11814212
56regulation of cytokine production involved in inflammatory response (GO:1900015)3.10908055
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.10295356
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10125756
59DNA deamination (GO:0045006)3.09602121
60regulation of cAMP-dependent protein kinase activity (GO:2000479)3.08672121
61postsynaptic membrane organization (GO:0001941)3.06419898
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.06324897
63transmission of nerve impulse (GO:0019226)3.06193777
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04053409
65head development (GO:0060322)3.03388295
66lateral sprouting from an epithelium (GO:0060601)3.03274015
67response to muramyl dipeptide (GO:0032495)3.02148074
68glutamate receptor signaling pathway (GO:0007215)3.02059689
69UV protection (GO:0009650)3.01327695
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00854654
71atrioventricular valve morphogenesis (GO:0003181)2.98148077
72cell migration in hindbrain (GO:0021535)2.97730127
73cerebral cortex radially oriented cell migration (GO:0021799)2.97415096
74regulation of synapse structural plasticity (GO:0051823)2.97081427
75regulation of respiratory gaseous exchange (GO:0043576)2.96463936
76sensory perception of taste (GO:0050909)2.95955082
77positive regulation of circadian rhythm (GO:0042753)2.92253546
78modulation by virus of host process (GO:0019054)2.92157334
79regulation of cholesterol metabolic process (GO:0090181)2.91926693
80protein localization to synapse (GO:0035418)2.89855056
81positive regulation of dendritic spine development (GO:0060999)2.89449267
82regulation of development, heterochronic (GO:0040034)2.88781881
83negative regulation of appetite (GO:0032099)2.86268423
84negative regulation of response to food (GO:0032096)2.86268423
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85085570
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82643554
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81083046
88response to misfolded protein (GO:0051788)2.79967116
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77938518
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76138745
91gamma-aminobutyric acid signaling pathway (GO:0007214)2.75811809
92serotonin receptor signaling pathway (GO:0007210)2.74979634
93axoneme assembly (GO:0035082)2.74646577
94positive regulation of Rap GTPase activity (GO:0032854)2.74463545
95positive regulation of protein deacetylation (GO:0090312)2.73999032
96opioid receptor signaling pathway (GO:0038003)2.73368234
97positive regulation of synapse maturation (GO:0090129)2.72757630
98startle response (GO:0001964)2.72048459
99vocalization behavior (GO:0071625)2.70164434
100positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68576671
101central nervous system projection neuron axonogenesis (GO:0021952)2.67869447
102regulation of chromatin binding (GO:0035561)2.65419521
103positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65391178
104positive regulation of DNA repair (GO:0045739)2.65376603
105adenosine receptor signaling pathway (GO:0001973)2.64941557
106negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.64685412
107cellular anion homeostasis (GO:0030002)2.64450331
108regulation of cholesterol biosynthetic process (GO:0045540)2.64329462
109sulfate transmembrane transport (GO:1902358)2.64256116
110negative regulation of neurotransmitter secretion (GO:0046929)2.63475195
111urinary tract smooth muscle contraction (GO:0014848)2.63412400
112embryonic process involved in female pregnancy (GO:0060136)2.63405182
113regulation of histone H3-K27 methylation (GO:0061085)2.63157027
114positive regulation of synapse assembly (GO:0051965)2.61494787
115glial cell migration (GO:0008347)2.60929373
116G-protein coupled receptor internalization (GO:0002031)2.59915159
117neuron fate specification (GO:0048665)2.59513905
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.59026079
119DNA double-strand break processing (GO:0000729)2.57948779
120histone H3-K4 methylation (GO:0051568)2.57156933
121negative regulation of neurotransmitter transport (GO:0051589)2.56375282
122adult feeding behavior (GO:0008343)2.56278169
123long-chain fatty acid biosynthetic process (GO:0042759)2.55093546
124embryonic camera-type eye development (GO:0031076)2.54934667
125regulation of gamma-delta T cell differentiation (GO:0045586)2.54873476
126negative regulation of granulocyte differentiation (GO:0030853)2.53928778
127regulation of integrin activation (GO:0033623)2.53578918
128sympathetic nervous system development (GO:0048485)2.53056930
129thymic T cell selection (GO:0045061)2.52805708
130neuron recognition (GO:0008038)2.51598982
131single strand break repair (GO:0000012)2.51564580
132regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50464963
133retrograde transport, endosome to Golgi (GO:0042147)2.49697601
134cranial nerve morphogenesis (GO:0021602)2.49323742
135regulation of skeletal muscle contraction (GO:0014819)2.48510734
136histone H3-K9 modification (GO:0061647)2.47653292
137regulation of mitochondrial depolarization (GO:0051900)2.47552909
138regulation of fatty acid beta-oxidation (GO:0031998)2.46556758
139axon ensheathment in central nervous system (GO:0032291)2.46545957
140central nervous system myelination (GO:0022010)2.46545957
141convergent extension (GO:0060026)2.46531385
142lung epithelium development (GO:0060428)2.46266612
143mesenchymal cell differentiation involved in renal system development (GO:2001012)2.45572094
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.45572094
145negative regulation of cell cycle arrest (GO:0071157)2.45283222
146activation of JUN kinase activity (GO:0007257)2.45077810
147cardiolipin metabolic process (GO:0032048)2.44692116
148sulfate transport (GO:0008272)2.44237733
149synaptic transmission, glutamatergic (GO:0035249)2.43551158
150positive thymic T cell selection (GO:0045059)2.42544410
151neuronal action potential propagation (GO:0019227)2.41943829
152cornea development in camera-type eye (GO:0061303)2.41913363
153positive regulation of meiosis (GO:0045836)2.40475310
154negative regulation of myotube differentiation (GO:0010832)2.40463876
155motile cilium assembly (GO:0044458)2.39602662
156regulation of protein homooligomerization (GO:0032462)2.39447645
157forebrain neuron differentiation (GO:0021879)2.39396691
158regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38364492
159stress granule assembly (GO:0034063)2.38354420
160dendritic spine morphogenesis (GO:0060997)2.37934520
161phosphate ion homeostasis (GO:0055062)2.37617971
162trivalent inorganic anion homeostasis (GO:0072506)2.37617971
163cell volume homeostasis (GO:0006884)2.36355542
164snRNA metabolic process (GO:0016073)2.36316895
165histone deacetylation (GO:0016575)2.36187977
166cell junction maintenance (GO:0034331)2.35940288
167regulation of cilium movement (GO:0003352)2.35186707
168osteoblast development (GO:0002076)2.34678783
169regulation of sensory perception (GO:0051931)2.34280258
170regulation of histone deacetylation (GO:0031063)2.32337940
171sex determination (GO:0007530)2.31417813
172histone H3-K9 demethylation (GO:0033169)2.30161902
173regulation of Rap GTPase activity (GO:0032317)2.29858015
174camera-type eye morphogenesis (GO:0048593)2.29193107
175establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29124187
176mitochondrion transport along microtubule (GO:0047497)2.29124187
177regulation of monocyte differentiation (GO:0045655)2.25388371
178regulation of synapse maturation (GO:0090128)2.25291474
179intracellular estrogen receptor signaling pathway (GO:0030520)2.25109346
180modulation by symbiont of host cellular process (GO:0044068)2.24824499
181histone lysine methylation (GO:0034968)2.24390134
182protein kinase C signaling (GO:0070528)2.21620199
183regulation of gamma-delta T cell activation (GO:0046643)2.20800268
184apoptotic process involved in morphogenesis (GO:0060561)2.19996200
185protein carboxylation (GO:0018214)2.18342307
186peptidyl-glutamic acid carboxylation (GO:0017187)2.18342307
187activation of Rac GTPase activity (GO:0032863)2.18080386
188ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.17925374
189synaptic vesicle exocytosis (GO:0016079)2.17046348
190entrainment of circadian clock by photoperiod (GO:0043153)2.16538099
191protein retention in ER lumen (GO:0006621)2.16453088
192insulin-like growth factor receptor signaling pathway (GO:0048009)2.16338751
193snRNA processing (GO:0016180)2.14327783
194diacylglycerol metabolic process (GO:0046339)2.12490960
195collecting duct development (GO:0072044)2.11814663
196histone deubiquitination (GO:0016578)2.11607275
197protein deacetylation (GO:0006476)2.11343483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67756147
2GBX2_23144817_ChIP-Seq_PC3_Human3.70970370
3* VDR_21846776_ChIP-Seq_THP-1_Human3.53830783
4LXR_22292898_ChIP-Seq_THP-1_Human3.31495131
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.90827160
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77233209
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.76333068
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.70935645
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.67116538
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.64626885
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.61584165
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60997791
13P68_20966046_ChIP-Seq_HELA_Human2.54820843
14KDM2B_26808549_Chip-Seq_DND41_Human2.51039573
15MYC_22102868_ChIP-Seq_BL_Human2.47956602
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43233150
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.41846736
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40393808
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.35580723
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.31616446
21TCF7_22412390_ChIP-Seq_EML_Mouse2.31382043
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.30217839
23* RACK7_27058665_Chip-Seq_MCF-7_Human2.26468121
24VDR_22108803_ChIP-Seq_LS180_Human2.26008906
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25581012
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22375468
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17044472
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16731057
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12820896
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12820896
31KDM2B_26808549_Chip-Seq_K562_Human2.12574119
32RNF2_27304074_Chip-Seq_NSC_Mouse2.10719532
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.03313596
34SMC4_20622854_ChIP-Seq_HELA_Human2.02110053
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02018545
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01816136
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01495744
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01495744
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01495744
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.98289337
41CTCF_27219007_Chip-Seq_Bcells_Human1.97995178
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97536869
43CREB1_26743006_Chip-Seq_LNCaP_Human1.94165155
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.93391162
45MAF_26560356_Chip-Seq_TH2_Human1.93236140
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93145451
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92829287
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.89872841
49REST_21632747_ChIP-Seq_MESCs_Mouse1.86017521
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.85485937
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85266883
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.83397008
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82486596
54AR_21572438_ChIP-Seq_LNCaP_Human1.82436708
55BCL6_27268052_Chip-Seq_Bcells_Human1.81896271
56VDR_24763502_ChIP-Seq_THP-1_Human1.79264601
57MAF_26560356_Chip-Seq_TH1_Human1.78556307
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.78244612
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78119094
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77960712
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77427119
62BCOR_27268052_Chip-Seq_Bcells_Human1.77149046
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.76462338
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72751599
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72071222
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.69496162
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69359371
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68901956
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68192911
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66190546
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.66148282
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64377737
73* PHF8_20622854_ChIP-Seq_HELA_Human1.63867909
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60098630
75E2F1_20622854_ChIP-Seq_HELA_Human1.59868954
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59372399
77TAF15_26573619_Chip-Seq_HEK293_Human1.59149111
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58853594
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58437009
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58119765
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58076122
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56206440
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56139748
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53449464
85* UTX_26944678_Chip-Seq_JUKART_Human1.53068647
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.50323065
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47679216
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47049323
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.46639425
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.46416190
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45559017
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45554900
93TP53_22127205_ChIP-Seq_IMR90_Human1.45473232
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44523709
95P300_18555785_Chip-Seq_ESCs_Mouse1.44352567
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.44110362
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.43935665
98P300_19829295_ChIP-Seq_ESCs_Human1.43752338
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42905610
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41792727
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.41229192
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39988990
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.39793726
104* NCOR1_26117541_ChIP-Seq_K562_Human1.36958944
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36390521
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.36189323
107FUS_26573619_Chip-Seq_HEK293_Human1.35913807
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35891281
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35648048
110TP63_22573176_ChIP-Seq_HFKS_Human1.35250557
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.34667402
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33959662
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.33721702
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.32964952
115P53_22387025_ChIP-Seq_ESCs_Mouse1.31516647
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.31312582
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31285223
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30739167
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30532173
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30197232
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.29229053
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.28899904
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28556111
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28556111
125KLF4_18555785_Chip-Seq_ESCs_Mouse1.27007853
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26301922
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.26213301
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25845366
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.25788974
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25007313
131SA1_27219007_Chip-Seq_Bcells_Human1.24666584
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.24571715
133TP63_17297297_ChIP-ChIP_HaCaT_Human1.23528869
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.23414236
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.22762632
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22186247
137CTCF_21964334_Chip-Seq_Bcells_Human1.21793394
138ESRRB_18555785_Chip-Seq_ESCs_Mouse1.21746187
139DROSHA_22980978_ChIP-Seq_HELA_Human1.21633617
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21552431
141RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21416506
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.20895376
143RUNX1_22412390_ChIP-Seq_EML_Mouse1.20097304
144OCT4_19829295_ChIP-Seq_ESCs_Human1.19925396
145RARB_27405468_Chip-Seq_BRAIN_Mouse1.18564939
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18216714
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17849238
148REST_18959480_ChIP-ChIP_MESCs_Mouse1.17826627
149SCL_19346495_ChIP-Seq_HPC-7_Human1.17245715
150CTCF_18555785_Chip-Seq_ESCs_Mouse1.15354383
151* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15209563
152CIITA_25753668_ChIP-Seq_RAJI_Human1.14986018
153YY1_22570637_ChIP-Seq_MALME-3M_Human1.13986970
154SMAD4_21799915_ChIP-Seq_A2780_Human1.13367507
155EZH2_27294783_Chip-Seq_NPCs_Mouse1.12696370
156P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12486402
157ETS1_21867929_ChIP-Seq_TH2_Mouse1.12372007
158GATA1_19941826_ChIP-Seq_K562_Human1.12349726
159ZFX_18555785_Chip-Seq_ESCs_Mouse1.12182208
160SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11589540
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10364652
162POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09962766
163SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09290991
164CTCF_20526341_ChIP-Seq_ESCs_Human1.09151560
165MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08639623
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07728424
167WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07120512
168VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06777385
169PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06239104
170RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06185081
171IGF1R_20145208_ChIP-Seq_DFB_Human1.05646033
172CTCF_26484167_Chip-Seq_Bcells_Mouse1.05248188
173SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05047888
174SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04907311
175PU1_27457419_Chip-Seq_LIVER_Mouse1.03587748
176ZNF263_19887448_ChIP-Seq_K562_Human1.03336862
177PIAS1_25552417_ChIP-Seq_VCAP_Human1.03074784
178TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02821495
179LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02083919
180JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01903833
181* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00907731
182CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00290470
183EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00104980
184STAT3_23295773_ChIP-Seq_U87_Human0.99842304
185KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99657769
186P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98741929
187TBL1_22424771_ChIP-Seq_293T_Human0.98530332
188LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97632363
189NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97225451
190* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97205158
191ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96225676
192PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95582546
193TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94801695
194GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94419225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation3.92168845
2MP0003136_yellow_coat_color3.88673518
3MP0006292_abnormal_olfactory_placode3.62183783
4MP0003880_abnormal_central_pattern3.25285993
5MP0009278_abnormal_bone_marrow3.12470180
6MP0003172_abnormal_lysosome_physiology3.02170525
7MP0001188_hyperpigmentation2.88421588
8MP0005076_abnormal_cell_differentiation2.83792267
9MP0002102_abnormal_ear_morphology2.76268348
10MP0003705_abnormal_hypodermis_morpholog2.72693931
11MP0005083_abnormal_biliary_tract2.64992921
12MP0008057_abnormal_DNA_replication2.62637679
13MP0005058_abnormal_lysosome_morphology2.27578391
14MP0008995_early_reproductive_senescence2.25233857
15MP0000566_synostosis2.23445364
16MP0002249_abnormal_larynx_morphology2.21310439
17MP0004858_abnormal_nervous_system2.17985770
18MP0009046_muscle_twitch2.14447181
19MP0005645_abnormal_hypothalamus_physiol2.13682901
20MP0000015_abnormal_ear_pigmentation2.09820468
21MP0001348_abnormal_lacrimal_gland2.09188768
22MP0006072_abnormal_retinal_apoptosis2.07327436
23MP0002009_preneoplasia2.05576331
24MP0001486_abnormal_startle_reflex2.04262141
25MP0000003_abnormal_adipose_tissue2.01403297
26MP0004859_abnormal_synaptic_plasticity1.98967345
27MP0000678_abnormal_parathyroid_gland1.96102313
28MP0005409_darkened_coat_color1.95563799
29MP0003436_decreased_susceptibility_to1.91793184
30MP0004130_abnormal_muscle_cell1.90349001
31MP0005174_abnormal_tail_pigmentation1.90080581
32MP0001545_abnormal_hematopoietic_system1.87635694
33MP0005397_hematopoietic_system_phenotyp1.87635694
34MP0003879_abnormal_hair_cell1.86504038
35MP0004142_abnormal_muscle_tone1.85369173
36MP0002572_abnormal_emotion/affect_behav1.84668513
37MP0001849_ear_inflammation1.84150141
38MP0003635_abnormal_synaptic_transmissio1.77251308
39MP0009745_abnormal_behavioral_response1.75841578
40MP0000778_abnormal_nervous_system1.73308023
41MP0000751_myopathy1.71975227
42MP0001958_emphysema1.68960037
43MP0002064_seizures1.66780786
44MP0002933_joint_inflammation1.66463734
45MP0004510_myositis1.65311383
46MP0002063_abnormal_learning/memory/cond1.65036741
47MP0002272_abnormal_nervous_system1.59733703
48MP0004133_heterotaxia1.56611584
49MP0003938_abnormal_ear_development1.56351141
50MP0005423_abnormal_somatic_nervous1.55625604
51MP0000026_abnormal_inner_ear1.55337463
52MP0010030_abnormal_orbit_morphology1.54436413
53MP0004742_abnormal_vestibular_system1.54424611
54MP0005375_adipose_tissue_phenotype1.50439636
55MP0009384_cardiac_valve_regurgitation1.50112292
56MP0001968_abnormal_touch/_nociception1.48700664
57MP0000049_abnormal_middle_ear1.48056672
58MP0001873_stomach_inflammation1.44042082
59MP0001485_abnormal_pinna_reflex1.43638718
60MP0008877_abnormal_DNA_methylation1.41228250
61MP0002277_abnormal_respiratory_mucosa1.40820720
62MP0002067_abnormal_sensory_capabilities1.39272558
63MP0004381_abnormal_hair_follicle1.38376589
64MP0000013_abnormal_adipose_tissue1.36671632
65MP0003787_abnormal_imprinting1.35817724
66MP0001970_abnormal_pain_threshold1.34723987
67MP0005646_abnormal_pituitary_gland1.34192408
68MP0008875_abnormal_xenobiotic_pharmacok1.33211350
69MP0003453_abnormal_keratinocyte_physiol1.33185362
70MP0005666_abnormal_adipose_tissue1.29948570
71MP0005551_abnormal_eye_electrophysiolog1.29052524
72MP0002184_abnormal_innervation1.28839684
73MP0000631_abnormal_neuroendocrine_gland1.26023358
74MP0001440_abnormal_grooming_behavior1.25706068
75MP0001765_abnormal_ion_homeostasis1.25613894
76MP0005253_abnormal_eye_physiology1.24727424
77MP0001963_abnormal_hearing_physiology1.23682141
78MP0002735_abnormal_chemical_nociception1.23571023
79MP0002733_abnormal_thermal_nociception1.23229626
80MP0003303_peritoneal_inflammation1.22984016
81MP0001502_abnormal_circadian_rhythm1.20903712
82MP0004043_abnormal_pH_regulation1.20483513
83MP0001664_abnormal_digestion1.20404892
84MP0002557_abnormal_social/conspecific_i1.17685043
85MP0003279_aneurysm1.17391768
86MP0005377_hearing/vestibular/ear_phenot1.17119243
87MP0003878_abnormal_ear_physiology1.17119243
88MP0006276_abnormal_autonomic_nervous1.16830831
89MP0002752_abnormal_somatic_nervous1.16811463
90MP0003890_abnormal_embryonic-extraembry1.16120466
91MP0001986_abnormal_taste_sensitivity1.16038851
92MP0002822_catalepsy1.14208125
93MP0004947_skin_inflammation1.12578063
94MP0004185_abnormal_adipocyte_glucose1.11939709
95MP0002751_abnormal_autonomic_nervous1.11899529
96MP0000462_abnormal_digestive_system1.10623501
97MP0003786_premature_aging1.08918075
98MP0001529_abnormal_vocalization1.07104987
99MP0002736_abnormal_nociception_after1.06979407
100MP0000762_abnormal_tongue_morphology1.06657295
101MP0000538_abnormal_urinary_bladder1.05193899
102MP0002734_abnormal_mechanical_nocicepti1.05082532
103MP0004270_analgesia1.04841763
104MP0002638_abnormal_pupillary_reflex1.04127599
105MP0002882_abnormal_neuron_morphology1.03821899
106MP0000955_abnormal_spinal_cord1.02875735
107MP0008260_abnormal_autophagy1.02725554
108MP0004233_abnormal_muscle_weight1.01658169
109MP0001501_abnormal_sleep_pattern0.99870563
110MP0002163_abnormal_gland_morphology0.99662327
111MP0001756_abnormal_urination0.97766288
112MP0005379_endocrine/exocrine_gland_phen0.96933714
113MP0010386_abnormal_urinary_bladder0.96817549
114MP0000750_abnormal_muscle_regeneration0.96231780
115MP0001905_abnormal_dopamine_level0.95211951
116MP0003755_abnormal_palate_morphology0.92860469
117MP0005220_abnormal_exocrine_pancreas0.92685988
118MP0009250_abnormal_appendicular_skeleto0.92624856
119MP0000579_abnormal_nail_morphology0.92624488
120MP0005365_abnormal_bile_salt0.92565034
121MP0008058_abnormal_DNA_repair0.91674213
122MP0004134_abnormal_chest_morphology0.91599863
123MP0003385_abnormal_body_wall0.91518973
124MP0000470_abnormal_stomach_morphology0.91438743
125MP0003137_abnormal_impulse_conducting0.90717627
126MP0005670_abnormal_white_adipose0.90586173
127MP0003763_abnormal_thymus_physiology0.90494469
128MP0002116_abnormal_craniofacial_bone0.90180276
129MP0003941_abnormal_skin_development0.90125004
130MP0001984_abnormal_olfaction0.88754622
131MP0002932_abnormal_joint_morphology0.88386244
132MP0003091_abnormal_cell_migration0.88052336
133MP0003948_abnormal_gas_homeostasis0.86828515
134MP0002066_abnormal_motor_capabilities/c0.86356241
135MP0005195_abnormal_posterior_eye0.85660953
136MP0003329_amyloid_beta_deposits0.85154916
137MP0002089_abnormal_postnatal_growth/wei0.85072542
138MP0009931_abnormal_skin_appearance0.84169017
139MP0000747_muscle_weakness0.84144443
140MP0002938_white_spotting0.84095988
141MP0002396_abnormal_hematopoietic_system0.83630887
142MP0003119_abnormal_digestive_system0.83426168
143MP0003656_abnormal_erythrocyte_physiolo0.82643513
144MP0003937_abnormal_limbs/digits/tail_de0.82301241
145MP0000681_abnormal_thyroid_gland0.80984057
146MP0005360_urolithiasis0.80531720
147MP0004145_abnormal_muscle_electrophysio0.79910176
148MP0005075_abnormal_melanosome_morpholog0.78892346
149MP0002152_abnormal_brain_morphology0.78781615
150MP0005535_abnormal_body_temperature0.78646050
151MP0004808_abnormal_hematopoietic_stem0.78261043
152MP0001340_abnormal_eyelid_morphology0.78061627
153MP0008789_abnormal_olfactory_epithelium0.77584605
154MP0002653_abnormal_ependyma_morphology0.76899180
155MP0003718_maternal_effect0.76655632
156MP0002282_abnormal_trachea_morphology0.75981132
157MP0005451_abnormal_body_composition0.74373892
158MP0008569_lethality_at_weaning0.73752986
159MP0005448_abnormal_energy_balance0.71143946
160MP0001663_abnormal_digestive_system0.70837475
161MP0001661_extended_life_span0.70265801
162MP0003866_abnormal_defecation0.65853634
163MP0009643_abnormal_urine_homeostasis0.65437601
164MP0001270_distended_abdomen0.64980067
165MP0002970_abnormal_white_adipose0.64118797
166MP0002971_abnormal_brown_adipose0.63369920
167MP0003115_abnormal_respiratory_system0.62449095
168MP0000703_abnormal_thymus_morphology0.62373362
169MP0003045_fibrosis0.62180943
170MP0002132_abnormal_respiratory_system0.61679659
171MP0005501_abnormal_skin_physiology0.61295525
172MP0010155_abnormal_intestine_physiology0.61022659
173MP0002398_abnormal_bone_marrow0.60707437
174MP0003183_abnormal_peptide_metabolism0.59462723
175MP0005499_abnormal_olfactory_system0.59371338
176MP0005394_taste/olfaction_phenotype0.59371338
177MP0002136_abnormal_kidney_physiology0.59007221

Predicted human phenotypes

RankGene SetZ-score
1Thin bony cortex (HP:0002753)4.77217326
2Obstructive sleep apnea (HP:0002870)4.72625416
3Abnormal respiratory motile cilium morphology (HP:0005938)4.37494830
4Abnormal respiratory epithelium morphology (HP:0012253)4.37494830
5Broad face (HP:0000283)3.97751856
6Concave nail (HP:0001598)3.94872207
7Abnormal ciliary motility (HP:0012262)3.83048616
8Absent/shortened dynein arms (HP:0200106)3.67768905
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.67768905
10Septo-optic dysplasia (HP:0100842)3.65210852
11Febrile seizures (HP:0002373)3.55608252
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55415182
13Ulnar bowing (HP:0003031)3.50444717
14Abnormality of the fingertips (HP:0001211)3.50097378
15Turricephaly (HP:0000262)3.44434524
16Focal motor seizures (HP:0011153)3.42566748
17Cervical subluxation (HP:0003308)3.34071885
18Hemorrhage of the eye (HP:0011885)3.29943667
19Rib fusion (HP:0000902)3.27699482
20Atelectasis (HP:0100750)3.24874892
21Increased IgM level (HP:0003496)3.22528087
22Abnormal respiratory motile cilium physiology (HP:0012261)3.20213024
23Hyperacusis (HP:0010780)3.09477055
24Testicular atrophy (HP:0000029)3.04434502
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03907605
26Intestinal atresia (HP:0011100)3.01599494
27Joint stiffness (HP:0001387)2.97029709
28Alacrima (HP:0000522)2.92615755
29Median cleft lip (HP:0000161)2.81128128
30Metaphyseal cupping (HP:0003021)2.75389961
31Rectovaginal fistula (HP:0000143)2.74236744
32Rectal fistula (HP:0100590)2.74236744
33Optic nerve hypoplasia (HP:0000609)2.73880619
34J-shaped sella turcica (HP:0002680)2.71810307
35Rectal prolapse (HP:0002035)2.66416121
36Duplicated collecting system (HP:0000081)2.64434657
37Absent septum pellucidum (HP:0001331)2.64047036
38Male infertility (HP:0003251)2.62975330
39Decreased lacrimation (HP:0000633)2.59617554
40Mucopolysacchariduria (HP:0008155)2.58414498
41Urinary glycosaminoglycan excretion (HP:0003541)2.58414498
42Chromsome breakage (HP:0040012)2.57658582
43Abnormality of polysaccharide metabolism (HP:0011012)2.56420616
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56420616
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56420616
46Absent radius (HP:0003974)2.52237312
47Stridor (HP:0010307)2.49972252
48Epileptic encephalopathy (HP:0200134)2.49791515
49Bronchomalacia (HP:0002780)2.47622131
50Amelogenesis imperfecta (HP:0000705)2.46268253
51Aplasia involving forearm bones (HP:0009822)2.44211792
52Absent forearm bone (HP:0003953)2.44211792
53Distal upper limb amyotrophy (HP:0007149)2.41162930
54Upper limb amyotrophy (HP:0009129)2.41162930
55Medial flaring of the eyebrow (HP:0010747)2.40155596
56Intestinal fistula (HP:0100819)2.39558389
57Cerebral aneurysm (HP:0004944)2.39380886
58Facial hemangioma (HP:0000329)2.37958988
59Abnormality of the nasal septum (HP:0000419)2.37863351
60Thickened helices (HP:0000391)2.37139280
61Abnormality of the renal collecting system (HP:0004742)2.35857851
62Easy fatigability (HP:0003388)2.34723578
63Genetic anticipation (HP:0003743)2.34376734
64Gait imbalance (HP:0002141)2.34229099
65Atonic seizures (HP:0010819)2.30477620
66Aplasia of the musculature (HP:0100854)2.29193462
67Aplasia cutis congenita (HP:0001057)2.29102626
68Abnormality of the septum pellucidum (HP:0007375)2.26953755
69Pointed chin (HP:0000307)2.25423649
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25399071
71Congenital primary aphakia (HP:0007707)2.24039636
72Thin ribs (HP:0000883)2.21212556
73Spinal canal stenosis (HP:0003416)2.18139875
74Hyperthyroidism (HP:0000836)2.16808710
75Coronal craniosynostosis (HP:0004440)2.16656243
76Nasal polyposis (HP:0100582)2.15181283
77Colitis (HP:0002583)2.13999160
78Akinesia (HP:0002304)2.13759124
79Nephrogenic diabetes insipidus (HP:0009806)2.12439946
80Abnormality of male internal genitalia (HP:0000022)2.11986681
81Popliteal pterygium (HP:0009756)2.10798849
82Abnormal sex determination (HP:0012244)2.09632274
83Sex reversal (HP:0012245)2.09632274
84Dysostosis multiplex (HP:0000943)2.09551447
85Upper limb muscle weakness (HP:0003484)2.09495430
86Supernumerary spleens (HP:0009799)2.09157583
87Osteomalacia (HP:0002749)2.08688843
88Clumsiness (HP:0002312)2.07926531
89Anophthalmia (HP:0000528)2.07186534
90Vaginal fistula (HP:0004320)2.05833452
91Narrow nasal bridge (HP:0000446)2.05238043
92White forelock (HP:0002211)2.04956480
93Mitral regurgitation (HP:0001653)2.04314821
94Anomalous pulmonary venous return (HP:0010772)2.01939512
95Truncus arteriosus (HP:0001660)2.01596151
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00915648
97Abnormality of the thoracic spine (HP:0100711)2.00498136
98Biconcave vertebral bodies (HP:0004586)1.99817988
99Papilledema (HP:0001085)1.98761875
100Decreased central vision (HP:0007663)1.98724691
101Spina bifida occulta (HP:0003298)1.95645295
102Abnormality of the nasal mucosa (HP:0000433)1.95057986
103Increased number of teeth (HP:0011069)1.93825022
104Sleep apnea (HP:0010535)1.93597646
105Patchy hypopigmentation of hair (HP:0011365)1.93062288
106Congenital sensorineural hearing impairment (HP:0008527)1.92999366
107Myopathic facies (HP:0002058)1.92400081
108Lymphangioma (HP:0100764)1.92128051
109Hypoplasia of the ulna (HP:0003022)1.91915234
110Duplication of thumb phalanx (HP:0009942)1.91781744
111Severe visual impairment (HP:0001141)1.91518961
112Emphysema (HP:0002097)1.90966791
113Broad distal phalanx of finger (HP:0009836)1.90783464
114Anteriorly placed anus (HP:0001545)1.90613897
115Reticulocytosis (HP:0001923)1.90590745
116Annular pancreas (HP:0001734)1.90489961
117Ankle clonus (HP:0011448)1.89611937
118Attenuation of retinal blood vessels (HP:0007843)1.89378134
119Fetal akinesia sequence (HP:0001989)1.88570754
120Male pseudohermaphroditism (HP:0000037)1.88156811
121Tented upper lip vermilion (HP:0010804)1.88054471
122Shallow orbits (HP:0000586)1.87516578
123Hand muscle atrophy (HP:0009130)1.87208871
124Gastroesophageal reflux (HP:0002020)1.85485111
125Dislocated radial head (HP:0003083)1.85288580
126Long palpebral fissure (HP:0000637)1.85139955
127Broad metatarsal (HP:0001783)1.84343020
128Hypertriglyceridemia (HP:0002155)1.84059064
129Abnormality of secondary sexual hair (HP:0009888)1.84019533
130Abnormality of the axillary hair (HP:0100134)1.84019533
131Thoracic kyphosis (HP:0002942)1.83851414
132Rhinitis (HP:0012384)1.82266112
133Lip pit (HP:0100267)1.81242850
134Precocious puberty (HP:0000826)1.80820282
135Nephronophthisis (HP:0000090)1.80677679
136Abnormality of the pulmonary veins (HP:0011718)1.80414584
137Hypotelorism (HP:0000601)1.79709675
138Germ cell neoplasia (HP:0100728)1.79270610
139Renal agenesis (HP:0000104)1.79135145
140Abnormality of the radial head (HP:0003995)1.78743655
141Capillary hemangiomas (HP:0005306)1.78248320
142Abnormality of the ileum (HP:0001549)1.77914088
143Squamous cell carcinoma (HP:0002860)1.77900526
144Focal seizures (HP:0007359)1.77837691
145Bowing of the arm (HP:0006488)1.77532144
146Bowed forearm bones (HP:0003956)1.77532144
147Exercise-induced myalgia (HP:0003738)1.76822501
148Congenital stationary night blindness (HP:0007642)1.76813827
149Aplasia/Hypoplasia of the lens (HP:0008063)1.76586466
150Long eyelashes (HP:0000527)1.76239639
151Nasolacrimal duct obstruction (HP:0000579)1.76178194
152Absent thumb (HP:0009777)1.76099722
153Ectopic anus (HP:0004397)1.75151151
154Short thumb (HP:0009778)1.74363398
155Bowel incontinence (HP:0002607)1.74054244
156Hamartoma (HP:0010566)1.73776333
157Broad-based gait (HP:0002136)1.73767489
158Morphological abnormality of the middle ear (HP:0008609)1.72962550
159Flat acetabular roof (HP:0003180)1.72344029
160Overfolded helix (HP:0000396)1.72012609
161Gastrointestinal atresia (HP:0002589)1.71835114
162Genital tract atresia (HP:0001827)1.71226223
163Bell-shaped thorax (HP:0001591)1.71196021
164Small hand (HP:0200055)1.71014155
165Aortic regurgitation (HP:0001659)1.70999724
166Hypochromic microcytic anemia (HP:0004840)1.70863522
167Tubulointerstitial nephritis (HP:0001970)1.70814556
168Vaginal atresia (HP:0000148)1.70001205
169Bifid uvula (HP:0000193)1.69929319
170Parakeratosis (HP:0001036)1.69748769
171Volvulus (HP:0002580)1.68567782
172Poikiloderma (HP:0001029)1.67746272
173Neoplasm of the heart (HP:0100544)1.67162997
174Abnormality of the aortic arch (HP:0012303)1.65930566
175Gastrointestinal inflammation (HP:0004386)1.65664587
176Nuclear cataract (HP:0100018)1.63432197
177Deformed sella turcica (HP:0002681)1.63377892
178Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63305110
179Mesangial abnormality (HP:0001966)1.61804844
180Delayed epiphyseal ossification (HP:0002663)1.60026835
181Neonatal onset (HP:0003623)1.59696883
182Seborrheic dermatitis (HP:0001051)1.59347802
183Patellar aplasia (HP:0006443)1.58552965
184Broad palm (HP:0001169)1.58020509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.47341509
2MAPK154.13386430
3CASK3.67309721
4SIK13.18781186
5ICK3.16255109
6BLK3.13570015
7FGR3.00041487
8ERN12.94446003
9MAP3K62.79070641
10PRPF4B2.50916765
11DDR22.49707272
12TNIK2.41767667
13YES12.25104131
14EEF2K2.15396277
15UHMK12.06732878
16EPHA42.04673789
17MKNK21.99840663
18MAP2K31.95864112
19PINK11.88654115
20PRKD21.83518950
21MAP4K11.78002586
22SMG11.70658485
23CDK121.65286787
24NTRK31.61254697
25STK161.53123077
26MAP3K71.50860166
27MAP2K71.47467973
28INSRR1.43697678
29AKT31.42906321
30RPS6KA21.41206765
31SIK21.37784565
32PKN21.36253024
33PRKD31.35816595
34CSK1.34962150
35NEK61.34911467
36GRK61.33519214
37MATK1.33451546
38RIPK11.32186019
39CAMKK11.29530826
40DAPK11.22417395
41MTOR1.20680705
42ZAP701.20657771
43EPHB11.18002520
44MAPK121.15911657
45MST1R1.15769049
46MAPK131.15497512
47BMPR21.14874961
48TNK21.13690294
49MAP2K61.13514911
50PIM21.12183374
51NTRK21.11463928
52CAMK1D1.10456571
53MAP3K101.09792732
54SIK31.07773166
55PKN11.05724150
56ADRBK21.02272294
57WNK41.01565355
58EPHA21.01359258
59GRK71.01097284
60CAMK2B0.99872445
61TYRO30.96341424
62TBK10.95824760
63FGFR40.95794586
64MAP2K40.93342133
65CAMK2A0.91536565
66PDPK10.91523061
67CDC42BPA0.91222009
68MUSK0.91193486
69IRAK20.90378343
70BMX0.89526609
71GRK10.88114643
72TAOK10.87948144
73BTK0.87323900
74PHKG10.87111093
75PHKG20.87111093
76PTK60.86899569
77RIPK40.86616025
78DYRK20.85053031
79MKNK10.84879759
80FES0.81628825
81IRAK40.80332189
82MARK10.80148367
83EIF2AK20.79848854
84WNK10.79010101
85MAP3K110.78860511
86CDK30.78234032
87KIT0.77535735
88CLK10.77346937
89PRKCH0.75948285
90IRAK30.75840174
91TRPM70.73799539
92LMTK20.71756997
93IRAK10.71551810
94MAPK110.71516167
95CDK190.71316505
96CDK70.70255711
97TESK20.70080024
98OXSR10.69414707
99MAP2K20.66786323
100TXK0.65313996
101WNK30.64121160
102MAPK80.63303632
103EPHB20.62094142
104RET0.61836651
105CAMK2D0.61459501
106NME10.61148139
107ERBB20.60285978
108TYK20.58868391
109IKBKE0.58541227
110PRKD10.58477824
111BMPR1B0.58389417
112CAMK1G0.58065698
113STK110.57943558
114TLK10.57672071
115SGK10.57488403
116MARK20.55740450
117PDGFRA0.55621725
118LYN0.55600535
119DYRK1B0.54935625
120RPS6KC10.54009288
121RPS6KL10.54009288
122CAMK2G0.52816081
123PDK10.52580864
124CHEK20.52395474
125PRKCE0.51611158
126MAPK70.51463816
127TTN0.51456573
128DAPK20.51379251
129DYRK1A0.50467209
130STK390.49743735
131PRKAA10.48259901
132NUAK10.48039602
133MAP3K40.46389187
134SGK30.46387881
135HIPK20.46387522
136STK38L0.46293900
137MAP3K10.45872670
138CAMK10.45704692
139SGK4940.44651769
140SGK2230.44651769
141MAPK100.44628278
142PAK60.44456399
143HCK0.43733411
144CDK50.43053084
145RPS6KA10.42257387
146GSK3A0.41920552
147KDR0.41188059
148RPS6KA60.40523855
149PTK20.40423431
150* MAPK30.40391776
151ZAK0.40332418
152PNCK0.40050265
153TAOK20.39677611
154BCR0.38987700
155DMPK0.38835498
156DYRK30.38310921
157PDGFRB0.37919307
158CDK40.37677790
159CAMK40.37210159
160RAF10.36342697
161PRKACA0.35674560
162SYK0.35131211
163PLK20.34674410
164MAP3K130.33667513
165PRKG10.33440862
166PRKAA20.31146886
167STK380.29975456
168ARAF0.29773028

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80267847
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93501049
3Other glycan degradation_Homo sapiens_hsa005112.74633081
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.56542967
5Fatty acid biosynthesis_Homo sapiens_hsa000612.55426418
6Phototransduction_Homo sapiens_hsa047442.42251331
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.39835429
8Fanconi anemia pathway_Homo sapiens_hsa034602.36997871
9Taste transduction_Homo sapiens_hsa047422.25198504
10Sulfur relay system_Homo sapiens_hsa041222.13375550
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10442553
12Morphine addiction_Homo sapiens_hsa050322.05280667
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00412003
14Serotonergic synapse_Homo sapiens_hsa047261.86854697
15VEGF signaling pathway_Homo sapiens_hsa043701.83654489
16Glutamatergic synapse_Homo sapiens_hsa047241.82542599
17GABAergic synapse_Homo sapiens_hsa047271.81131458
18Mismatch repair_Homo sapiens_hsa034301.73835402
19Circadian rhythm_Homo sapiens_hsa047101.68582796
20Homologous recombination_Homo sapiens_hsa034401.68016171
21Fructose and mannose metabolism_Homo sapiens_hsa000511.67498981
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65185250
23Olfactory transduction_Homo sapiens_hsa047401.58499663
24Acute myeloid leukemia_Homo sapiens_hsa052211.53905063
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.51183383
26mTOR signaling pathway_Homo sapiens_hsa041501.43026875
27Circadian entrainment_Homo sapiens_hsa047131.42155612
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41394229
29Lysine degradation_Homo sapiens_hsa003101.40116245
30Base excision repair_Homo sapiens_hsa034101.39994847
31Hedgehog signaling pathway_Homo sapiens_hsa043401.38078647
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36226667
33Axon guidance_Homo sapiens_hsa043601.35147451
34Phospholipase D signaling pathway_Homo sapiens_hsa040721.33766123
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.33673046
36Non-small cell lung cancer_Homo sapiens_hsa052231.31397034
37Calcium signaling pathway_Homo sapiens_hsa040201.31143928
38Wnt signaling pathway_Homo sapiens_hsa043101.29080668
39Chronic myeloid leukemia_Homo sapiens_hsa052201.28003267
40Inositol phosphate metabolism_Homo sapiens_hsa005621.27549685
41Salivary secretion_Homo sapiens_hsa049701.26908263
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.25499676
43Long-term depression_Homo sapiens_hsa047301.24780193
44Amphetamine addiction_Homo sapiens_hsa050311.23296245
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20016448
46ABC transporters_Homo sapiens_hsa020101.17936398
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13858340
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12050715
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12032567
50Oxidative phosphorylation_Homo sapiens_hsa001901.07950861
51Ether lipid metabolism_Homo sapiens_hsa005651.07059685
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05774389
53Arachidonic acid metabolism_Homo sapiens_hsa005901.05201167
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04109144
55Dopaminergic synapse_Homo sapiens_hsa047281.00980573
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99811704
57Autoimmune thyroid disease_Homo sapiens_hsa053200.99135771
58Insulin resistance_Homo sapiens_hsa049310.98669790
59B cell receptor signaling pathway_Homo sapiens_hsa046620.97854667
60Basal cell carcinoma_Homo sapiens_hsa052170.97488793
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96920933
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95938766
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94356645
64Sphingolipid metabolism_Homo sapiens_hsa006000.94159212
65Insulin signaling pathway_Homo sapiens_hsa049100.91765311
66Arginine and proline metabolism_Homo sapiens_hsa003300.91726295
67AMPK signaling pathway_Homo sapiens_hsa041520.91671695
68Notch signaling pathway_Homo sapiens_hsa043300.90819796
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88763027
70Synaptic vesicle cycle_Homo sapiens_hsa047210.88436167
71Hepatitis C_Homo sapiens_hsa051600.88235155
72Renin secretion_Homo sapiens_hsa049240.87886064
73Endometrial cancer_Homo sapiens_hsa052130.87861762
74Pancreatic cancer_Homo sapiens_hsa052120.87548506
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.86951262
76Choline metabolism in cancer_Homo sapiens_hsa052310.86109534
77Ras signaling pathway_Homo sapiens_hsa040140.85519062
78Cholinergic synapse_Homo sapiens_hsa047250.84708254
79Insulin secretion_Homo sapiens_hsa049110.84658169
80Steroid biosynthesis_Homo sapiens_hsa001000.84467376
81Nucleotide excision repair_Homo sapiens_hsa034200.83970084
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82716780
83Endocytosis_Homo sapiens_hsa041440.81180741
84Collecting duct acid secretion_Homo sapiens_hsa049660.80781759
85Osteoclast differentiation_Homo sapiens_hsa043800.80779468
86ErbB signaling pathway_Homo sapiens_hsa040120.80491861
87Oxytocin signaling pathway_Homo sapiens_hsa049210.80488076
88Gap junction_Homo sapiens_hsa045400.78644572
89Estrogen signaling pathway_Homo sapiens_hsa049150.78363728
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77146133
91cAMP signaling pathway_Homo sapiens_hsa040240.76958413
92Hippo signaling pathway_Homo sapiens_hsa043900.76449825
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75917321
94Alzheimers disease_Homo sapiens_hsa050100.75902256
95Linoleic acid metabolism_Homo sapiens_hsa005910.75695027
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75630838
97Non-homologous end-joining_Homo sapiens_hsa034500.74300172
98Cardiac muscle contraction_Homo sapiens_hsa042600.72758047
99Mineral absorption_Homo sapiens_hsa049780.72402700
100Long-term potentiation_Homo sapiens_hsa047200.72125407
101Glioma_Homo sapiens_hsa052140.71415472
102Bladder cancer_Homo sapiens_hsa052190.71359848
103MAPK signaling pathway_Homo sapiens_hsa040100.71358632
104Cocaine addiction_Homo sapiens_hsa050300.70373706
105Huntingtons disease_Homo sapiens_hsa050160.70266152
106Prolactin signaling pathway_Homo sapiens_hsa049170.69430596
107Colorectal cancer_Homo sapiens_hsa052100.69278052
108Bile secretion_Homo sapiens_hsa049760.68073497
109Primary immunodeficiency_Homo sapiens_hsa053400.65424217
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63629595
111Lysosome_Homo sapiens_hsa041420.63515248
112Type II diabetes mellitus_Homo sapiens_hsa049300.62964806
113Fatty acid elongation_Homo sapiens_hsa000620.62184150
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61765620
115Dorso-ventral axis formation_Homo sapiens_hsa043200.61642574
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61561054
117Melanogenesis_Homo sapiens_hsa049160.61379510
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61238580
119Rheumatoid arthritis_Homo sapiens_hsa053230.60411741
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.59768591
121GnRH signaling pathway_Homo sapiens_hsa049120.59190675
122T cell receptor signaling pathway_Homo sapiens_hsa046600.58721302
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.58579661
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57591144
125FoxO signaling pathway_Homo sapiens_hsa040680.57522694
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56845036
127African trypanosomiasis_Homo sapiens_hsa051430.56794943
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56483440
129Glucagon signaling pathway_Homo sapiens_hsa049220.56482613
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56305430
131Graft-versus-host disease_Homo sapiens_hsa053320.56166935
132Renal cell carcinoma_Homo sapiens_hsa052110.56100751
133Basal transcription factors_Homo sapiens_hsa030220.55883816
134mRNA surveillance pathway_Homo sapiens_hsa030150.54672768
135TNF signaling pathway_Homo sapiens_hsa046680.54513902
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.54295767
137Melanoma_Homo sapiens_hsa052180.53774138
138Platelet activation_Homo sapiens_hsa046110.52972061
139Phenylalanine metabolism_Homo sapiens_hsa003600.52810410
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51406227
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51212110
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51077392
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49951272
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49573336
145Gastric acid secretion_Homo sapiens_hsa049710.48964954
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.48763979
147Hepatitis B_Homo sapiens_hsa051610.48562506
148TGF-beta signaling pathway_Homo sapiens_hsa043500.48521437
149Glycerolipid metabolism_Homo sapiens_hsa005610.47726942
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45526820
151Parkinsons disease_Homo sapiens_hsa050120.45407940
152Rap1 signaling pathway_Homo sapiens_hsa040150.45304190
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45092238
154Asthma_Homo sapiens_hsa053100.44051920
155Allograft rejection_Homo sapiens_hsa053300.43787941
156Leishmaniasis_Homo sapiens_hsa051400.42926220
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42775955
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42202077
159Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41488299
160DNA replication_Homo sapiens_hsa030300.41006315
161Ovarian steroidogenesis_Homo sapiens_hsa049130.39959203
162Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38564151
163Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36908586
164Pancreatic secretion_Homo sapiens_hsa049720.36004794

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