ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	7.79463159
2	viral transcription (GO:0019083)	6.88008619
3	translational termination (GO:0006415)	6.47580142
4	ribosomal small subunit assembly (GO:0000028)	6.08252069
5	translational elongation (GO:0006414)	5.80172321
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.57729966
7	cotranslational protein targeting to membrane (GO:0006613)	5.45411485
8	protein targeting to ER (GO:0045047)	5.45219322
9	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.32512524
10	maturation of SSU-rRNA (GO:0030490)	5.28893437
11	GTP biosynthetic process (GO:0006183)	5.27293400
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.23799525
13	protein complex biogenesis (GO:0070271)	5.20224582
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.19025214
15	ATP synthesis coupled proton transport (GO:0015986)	5.18019621
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.18019621
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.15826569
18	UTP biosynthetic process (GO:0006228)	5.14556159
19	protein localization to endoplasmic reticulum (GO:0070972)	5.13597028
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.07613922
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.07613922
22	NADH dehydrogenase complex assembly (GO:0010257)	5.07613922
23	viral life cycle (GO:0019058)	5.07304159
24	cellular protein complex disassembly (GO:0043624)	4.96818551
25	mitochondrial respiratory chain complex assembly (GO:0033108)	4.92295295
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.86508483
27	UTP metabolic process (GO:0046051)	4.72220287
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.60123428
29	respiratory electron transport chain (GO:0022904)	4.55644376
30	guanosine-containing compound biosynthetic process (GO:1901070)	4.55572216
31	electron transport chain (GO:0022900)	4.51442539
32	chaperone-mediated protein transport (GO:0072321)	4.45318114
33	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.43606638
34	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.43506506
35	base-excision repair, AP site formation (GO:0006285)	4.42580644
36	protein complex disassembly (GO:0043241)	4.40400757
37	translational initiation (GO:0006413)	4.40323335
38	pyrimidine nucleotide catabolic process (GO:0006244)	4.37207160
39	CTP biosynthetic process (GO:0006241)	4.31585547
40	CTP metabolic process (GO:0046036)	4.31585547
41	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.27703532
42	regulation of mitochondrial translation (GO:0070129)	4.19160152
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.18057689
44	macromolecular complex disassembly (GO:0032984)	4.14396462
45	pseudouridine synthesis (GO:0001522)	4.08130547
46	cellular component biogenesis (GO:0044085)	4.02705732
47	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	4.01079869
48	translation (GO:0006412)	3.99762879
49	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.96090947
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.87487535
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.87287149
52	protein targeting to mitochondrion (GO:0006626)	3.86047467
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.79537131
54	cytochrome complex assembly (GO:0017004)	3.74657362
55	establishment of protein localization to mitochondrion (GO:0072655)	3.72279419
56	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.70455706
57	peptidyl-histidine modification (GO:0018202)	3.66440251
58	protein targeting to membrane (GO:0006612)	3.64110882
59	ncRNA 3-end processing (GO:0043628)	3.56099475
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51881248
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51881248
62	respiratory chain complex IV assembly (GO:0008535)	3.50087821
63	iron-sulfur cluster assembly (GO:0016226)	3.46289868
64	metallo-sulfur cluster assembly (GO:0031163)	3.46289868
65	protein neddylation (GO:0045116)	3.43640151
66	ATP biosynthetic process (GO:0006754)	3.43338314
67	ribosomal large subunit biogenesis (GO:0042273)	3.39008971
68	rRNA processing (GO:0006364)	3.38501632
69	deoxyribonucleotide catabolic process (GO:0009264)	3.37480509
70	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.35382818
71	termination of RNA polymerase III transcription (GO:0006386)	3.35382818
72	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.34752327
73	protein localization to mitochondrion (GO:0070585)	3.33862192
74	DNA deamination (GO:0045006)	3.27281653
75	rRNA metabolic process (GO:0016072)	3.26896478
76	oxidative phosphorylation (GO:0006119)	3.23985041
77	nucleoside triphosphate biosynthetic process (GO:0009142)	3.20029010
78	mRNA catabolic process (GO:0006402)	3.19731918
79	GMP metabolic process (GO:0046037)	3.19236494
80	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.07421772
81	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.05800657
82	deoxyribose phosphate catabolic process (GO:0046386)	3.03377470
83	transcription from mitochondrial promoter (GO:0006390)	2.98559522
84	tRNA processing (GO:0008033)	2.97805681
85	RNA catabolic process (GO:0006401)	2.96830533
86	negative regulation of telomere maintenance (GO:0032205)	2.95851721
87	hydrogen ion transmembrane transport (GO:1902600)	2.95046382
88	mitochondrial transport (GO:0006839)	2.92522850
89	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.92457537
90	GDP-mannose metabolic process (GO:0019673)	2.89650867
91	tRNA modification (GO:0006400)	2.89582786
92	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.88934928
93	2-deoxyribonucleotide metabolic process (GO:0009394)	2.87083970
94	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.86697469
95	nucleoside diphosphate phosphorylation (GO:0006165)	2.86135745
96	inner mitochondrial membrane organization (GO:0007007)	2.85930180
97	pyrimidine nucleotide metabolic process (GO:0006220)	2.85588234
98	ncRNA processing (GO:0034470)	2.83572851
99	protein targeting (GO:0006605)	2.82432652
100	rRNA modification (GO:0000154)	2.81975295

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.75931510
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.37302947
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.34182667
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.99541464
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.91141601
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.85244435
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.62141950
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.60930707
9	XRN2_22483619_ChIP-Seq_HELA_Human	2.46779692
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41085811
11	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.32455567
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.31363935
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.29481079
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.28474253
15	VDR_21846776_ChIP-Seq_THP-1_Human	2.15467751
16	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.15311940
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11125252
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10969459
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.08659440
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.05646602
21	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.97771602
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.95878562
23	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.90667170
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.86218167
25	P68_20966046_ChIP-Seq_HELA_Human	1.81158707
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.79607134
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.79579525
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.79538820
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.77823033
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.77697947
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.75840896
32	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.71718024
33	DCP1A_22483619_ChIP-Seq_HELA_Human	1.71659574
34	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.67356431
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.66988739
36	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.66571832
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65964965
38	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.61776194
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60674905
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.57891857
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.57632878
42	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.56098751
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.55026173
44	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53487453
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.53218653
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49274009
47	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.49232162
48	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.48326474
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.47741067
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47528742
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46213631
52	MYC_22102868_ChIP-Seq_BL_Human	1.41233332
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.40208507
54	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.38238645
55	PHF8_20622854_ChIP-Seq_HELA_Human	1.36752676
56	ZNF263_19887448_ChIP-Seq_K562_Human	1.35334822
57	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.33711278
58	E2F1_20622854_ChIP-Seq_HELA_Human	1.32982190
59	BCOR_27268052_Chip-Seq_Bcells_Human	1.31835237
60	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.31420511
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.29589607
62	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.29444842
63	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28819446
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28619432
65	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.28280623
66	CTCF_27219007_Chip-Seq_Bcells_Human	1.28060314
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.24285297
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.23478548
69	CTCF_20526341_ChIP-Seq_ESCs_Human	1.22249628
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.21466203
71	SA1_27219007_Chip-Seq_Bcells_Human	1.21319955
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.20772397
73	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19546006
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.16605710
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13299573
76	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.12060228
77	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.10865379
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10263314
79	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.09660690
80	ERA_21632823_ChIP-Seq_H3396_Human	1.08478132
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.08014834
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.07677617
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.07641094
84	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.07199333
85	MAF_26560356_Chip-Seq_TH2_Human	1.06848708
86	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.05899713
87	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.04827850
88	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04730149
89	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.03560980
90	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.03048450
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02060511
92	SMC4_20622854_ChIP-Seq_HELA_Human	0.99962980
93	P300_27268052_Chip-Seq_Bcells_Human	0.99741498
94	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.99025552
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98533972
96	CTCF_21964334_Chip-Seq_Bcells_Human	0.98139202
97	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.97361922
98	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95944727
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95850621
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.95784319

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.98564521
2	MP0002163_abnormal_gland_morphology	3.60033574
3	MP0003123_paternal_imprinting	3.37274221
4	MP0006292_abnormal_olfactory_placode	3.17134776
5	MP0002234_abnormal_pharynx_morphology	2.66323190
6	MP0002160_abnormal_reproductive_system	2.22523250
7	MP0005379_endocrine/exocrine_gland_phen	2.01441049
8	MP0005646_abnormal_pituitary_gland	2.01173261
9	MP0003787_abnormal_imprinting	1.97048371
10	MP0000678_abnormal_parathyroid_gland	1.96420523
11	MP0003693_abnormal_embryo_hatching	1.95607513
12	MP0002837_dystrophic_cardiac_calcinosis	1.92936130
13	MP0008058_abnormal_DNA_repair	1.92446584
14	MP0006036_abnormal_mitochondrial_physio	1.89169085
15	MP0005645_abnormal_hypothalamus_physiol	1.82870406
16	MP0001905_abnormal_dopamine_level	1.76093817
17	MP0001529_abnormal_vocalization	1.70974450
18	MP0000049_abnormal_middle_ear	1.70341925
19	MP0001968_abnormal_touch/_nociception	1.68250579
20	MP0004133_heterotaxia	1.65999911
21	MP0005389_reproductive_system_phenotype	1.65187507
22	MP0002736_abnormal_nociception_after	1.60158691
23	MP0002653_abnormal_ependyma_morphology	1.53696355
24	MP0001919_abnormal_reproductive_system	1.51738134
25	MP0004145_abnormal_muscle_electrophysio	1.44481385
26	MP0003186_abnormal_redox_activity	1.40758099
27	MP0004858_abnormal_nervous_system	1.40548375
28	MP0002249_abnormal_larynx_morphology	1.39631753
29	MP0008872_abnormal_physiological_respon	1.39630612
30	MP0003786_premature_aging	1.38538073
31	MP0000566_synostosis	1.38426798
32	MP0006276_abnormal_autonomic_nervous	1.38391347
33	MP0001188_hyperpigmentation	1.37917365
34	MP0010094_abnormal_chromosome_stability	1.37154050
35	MP0003121_genomic_imprinting	1.35997805
36	MP0003111_abnormal_nucleus_morphology	1.35792231
37	MP0004142_abnormal_muscle_tone	1.34241293
38	MP0002876_abnormal_thyroid_physiology	1.31972867
39	MP0000631_abnormal_neuroendocrine_gland	1.28855561
40	MP0002822_catalepsy	1.27622990
41	MP0005670_abnormal_white_adipose	1.24604137
42	MP0005499_abnormal_olfactory_system	1.24357740
43	MP0005394_taste/olfaction_phenotype	1.24357740
44	MP0002938_white_spotting	1.23228921
45	MP0008932_abnormal_embryonic_tissue	1.22552509
46	MP0002557_abnormal_social/conspecific_i	1.21860648
47	MP0008789_abnormal_olfactory_epithelium	1.20936472
48	MP0006035_abnormal_mitochondrial_morpho	1.20786435
49	MP0001944_abnormal_pancreas_morphology	1.16579123
50	MP0005451_abnormal_body_composition	1.15038836
51	MP0005423_abnormal_somatic_nervous	1.14418343
52	MP0003880_abnormal_central_pattern	1.13843085
53	MP0008875_abnormal_xenobiotic_pharmacok	1.12278088
54	MP0009046_muscle_twitch	1.12240977
55	MP0009745_abnormal_behavioral_response	1.11772132
56	MP0002210_abnormal_sex_determination	1.09424646
57	MP0009053_abnormal_anal_canal	1.09114985
58	MP0000681_abnormal_thyroid_gland	1.09031005
59	MP0003315_abnormal_perineum_morphology	1.08283422
60	MP0009333_abnormal_splenocyte_physiolog	1.08261526
61	MP0000538_abnormal_urinary_bladder	1.06106014
62	MP0000372_irregular_coat_pigmentation	1.05295608
63	MP0005551_abnormal_eye_electrophysiolog	1.04921348
64	MP0005220_abnormal_exocrine_pancreas	1.03738667
65	MP0003122_maternal_imprinting	1.03083431
66	MP0002733_abnormal_thermal_nociception	1.00785636
67	MP0003283_abnormal_digestive_organ	1.00209222
68	MP0001764_abnormal_homeostasis	0.97909228
69	MP0003938_abnormal_ear_development	0.96526021
70	MP0002064_seizures	0.95954046
71	MP0005332_abnormal_amino_acid	0.95846372
72	MP0003942_abnormal_urinary_system	0.94955376
73	MP0004147_increased_porphyrin_level	0.93738998
74	MP0002184_abnormal_innervation	0.88593198
75	MP0002693_abnormal_pancreas_physiology	0.88489798
76	MP0010030_abnormal_orbit_morphology	0.88000643
77	MP0001873_stomach_inflammation	0.87659551
78	MP0008995_early_reproductive_senescence	0.87182995
79	MP0003646_muscle_fatigue	0.86636227
80	MP0002272_abnormal_nervous_system	0.84348626
81	MP0003077_abnormal_cell_cycle	0.84087988
82	MP0001348_abnormal_lacrimal_gland	0.83102886
83	MP0001145_abnormal_male_reproductive	0.82910869
84	MP0003011_delayed_dark_adaptation	0.82069664
85	MP0002752_abnormal_somatic_nervous	0.80813796
86	MP0000026_abnormal_inner_ear	0.79691212
87	MP0005360_urolithiasis	0.78486234
88	MP0001970_abnormal_pain_threshold	0.78193909
89	MP0001270_distended_abdomen	0.76965725
90	MP0002572_abnormal_emotion/affect_behav	0.76922424
91	MP0003137_abnormal_impulse_conducting	0.74583890
92	MP0000653_abnormal_sex_gland	0.72157867
93	MP0002928_abnormal_bile_duct	0.70771208
94	MP0006072_abnormal_retinal_apoptosis	0.70741344
95	MP0003698_abnormal_male_reproductive	0.69682512
96	MP0005195_abnormal_posterior_eye	0.69550895
97	MP0000955_abnormal_spinal_cord	0.69471812
98	MP0003635_abnormal_synaptic_transmissio	0.69024292
99	MP0002063_abnormal_learning/memory/cond	0.68575928
100	MP0000750_abnormal_muscle_regeneration	0.68218786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.13020338
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.00597835
3	Mitochondrial inheritance (HP:0001427)	4.86843734
4	Acute encephalopathy (HP:0006846)	4.53721310
5	Hepatocellular necrosis (HP:0001404)	4.50186234
6	Abnormality of cells of the erythroid lineage (HP:0012130)	4.45847950
7	Abnormal number of erythroid precursors (HP:0012131)	4.36579834
8	Increased CSF lactate (HP:0002490)	4.36080151
9	Hepatic necrosis (HP:0002605)	4.33207792
10	Progressive macrocephaly (HP:0004481)	4.11112365
11	Reticulocytopenia (HP:0001896)	4.00349283
12	Increased intramyocellular lipid droplets (HP:0012240)	3.52640878
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.51865156
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.51865156
15	Increased hepatocellular lipid droplets (HP:0006565)	3.44970182
16	Lipid accumulation in hepatocytes (HP:0006561)	3.42004149
17	Hyperthyroidism (HP:0000836)	3.36560867
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.31625467
19	Increased muscle lipid content (HP:0009058)	3.30780037
20	Renal Fanconi syndrome (HP:0001994)	3.27529218
21	Microretrognathia (HP:0000308)	3.17416849
22	Increased serum lactate (HP:0002151)	3.16345270
23	Cerebral edema (HP:0002181)	3.08881862
24	Lactic acidosis (HP:0003128)	3.05425212
25	3-Methylglutaconic aciduria (HP:0003535)	2.99553753
26	Macrocytic anemia (HP:0001972)	2.98838925
27	Type II lissencephaly (HP:0007260)	2.84518631
28	Exercise intolerance (HP:0003546)	2.73624215
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.73577810
30	Respiratory failure (HP:0002878)	2.64156940
31	Testicular atrophy (HP:0000029)	2.55681927
32	Pallor (HP:0000980)	2.54762079
33	Absent thumb (HP:0009777)	2.51850773
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50421248
35	Broad distal phalanx of finger (HP:0009836)	2.48065905
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.46576307
37	Respiratory difficulties (HP:0002880)	2.40617202
38	Squamous cell carcinoma (HP:0002860)	2.34928829
39	Optic disc pallor (HP:0000543)	2.34801242
40	Myokymia (HP:0002411)	2.29503042
41	Truncus arteriosus (HP:0001660)	2.28752020
42	Progressive microcephaly (HP:0000253)	2.26322335
43	Microvesicular hepatic steatosis (HP:0001414)	2.25452217
44	Double outlet right ventricle (HP:0001719)	2.23368376
45	Congenital malformation of the right heart (HP:0011723)	2.23368376
46	Congenital stationary night blindness (HP:0007642)	2.21017781
47	Concave nail (HP:0001598)	2.20010649
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.19951761
49	Dicarboxylic aciduria (HP:0003215)	2.19951761
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.17519304
51	Exertional dyspnea (HP:0002875)	2.16749402
52	Aplasia/Hypoplasia of the patella (HP:0006498)	2.15149395
53	Retinal dysplasia (HP:0007973)	2.14873527
54	Abnormality of midbrain morphology (HP:0002418)	2.14416928
55	Molar tooth sign on MRI (HP:0002419)	2.14416928
56	Emotional lability (HP:0000712)	2.12654858
57	Severe muscular hypotonia (HP:0006829)	2.12297972
58	Leukodystrophy (HP:0002415)	2.06960406
59	Sclerocornea (HP:0000647)	2.06597791
60	Cerebral hypomyelination (HP:0006808)	2.02457981
61	Hyperglycinemia (HP:0002154)	2.00882232
62	Generalized aminoaciduria (HP:0002909)	2.00848737
63	Abnormality of urine glucose concentration (HP:0011016)	2.00374131
64	Glycosuria (HP:0003076)	2.00374131
65	Lethargy (HP:0001254)	1.98475842
66	Renal cortical cysts (HP:0000803)	1.96396410
67	CNS demyelination (HP:0007305)	1.94858285
68	Pancreatic fibrosis (HP:0100732)	1.90672265
69	Abnormality of magnesium homeostasis (HP:0004921)	1.89786691
70	Patellar aplasia (HP:0006443)	1.86886073
71	Opisthotonus (HP:0002179)	1.86116312
72	Aplastic anemia (HP:0001915)	1.84116732
73	Cerebellar dysplasia (HP:0007033)	1.83671904
74	Pendular nystagmus (HP:0012043)	1.83142900
75	Pancreatic cysts (HP:0001737)	1.83037743
76	Abnormality of DNA repair (HP:0003254)	1.82661940
77	Ketosis (HP:0001946)	1.82462232
78	Cleft eyelid (HP:0000625)	1.81450164
79	Pancytopenia (HP:0001876)	1.76647860
80	Horseshoe kidney (HP:0000085)	1.75903176
81	Abnormality of renal resorption (HP:0011038)	1.75806556
82	Rectal prolapse (HP:0002035)	1.72351408
83	Abnormal glycosylation (HP:0012345)	1.71984458
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.71984458
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.71984458
86	Abnormal protein glycosylation (HP:0012346)	1.71984458
87	Hypoplasia of the radius (HP:0002984)	1.69191595
88	Pachygyria (HP:0001302)	1.68186602
89	Lissencephaly (HP:0001339)	1.67872042
90	Abnormality of the aortic arch (HP:0012303)	1.65996160
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.61036779
92	Abnormality of alanine metabolism (HP:0010916)	1.61036779
93	Hyperalaninemia (HP:0003348)	1.61036779
94	Gliosis (HP:0002171)	1.60811249
95	Cerebral palsy (HP:0100021)	1.58555886
96	Methylmalonic aciduria (HP:0012120)	1.58389351
97	Delayed CNS myelination (HP:0002188)	1.57904952
98	Septate vagina (HP:0001153)	1.57442601
99	Blindness (HP:0000618)	1.57383086
100	Abnormality of the renal cortex (HP:0011035)	1.57186604

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.58757981
2	TLK1	4.04314270
3	STK16	3.76179322
4	VRK2	3.21056529
5	BCKDK	2.57060236
6	ZAK	2.45331825
7	PIM2	2.38358654
8	MAP3K11	2.04866594
9	TRIB3	1.96528439
10	KDR	1.89719865
11	IRAK3	1.88397059
12	SMG1	1.78306088
13	ARAF	1.76957617
14	BUB1	1.76607389
15	DYRK2	1.74384037
16	TESK2	1.70078676
17	ABL2	1.60357101
18	WNK4	1.56945337
19	ILK	1.55915179
20	VRK1	1.52385984
21	RPS6KA5	1.51843492
22	NME1	1.49963143
23	AURKA	1.43025208
24	PRKCI	1.36598923
25	LRRK2	1.32874997
26	BRAF	1.32010130
27	MAP4K2	1.31754235
28	CDC7	1.30640260
29	ADRBK2	1.29597253
30	CHEK2	1.26842544
31	CSNK1G3	1.19292301
32	DAPK3	1.16449703
33	SIK1	1.04229537
34	RPS6KB2	1.04021964
35	GRK1	1.03650665
36	CDK8	0.99643359
37	FRK	0.98087291
38	MAP4K1	0.97514684
39	ATR	0.95829832
40	MUSK	0.94702605
41	ICK	0.92772581
42	CAMKK1	0.92623294
43	IKBKB	0.86208861
44	MAP2K7	0.85681372
45	MAP2K6	0.85313095
46	SIK2	0.85250865
47	CSNK1G2	0.84879206
48	MAPKAPK3	0.82939157
49	STK4	0.82780330
50	PKN1	0.79809093
51	BRSK1	0.79754783
52	INSRR	0.78373002
53	RPS6KA6	0.78302954
54	CSNK1A1L	0.75969023
55	CSNK1G1	0.75570274
56	MAPK13	0.75415521
57	PRKD3	0.75221819
58	MAP2K2	0.73227780
59	HIPK2	0.71917628
60	PINK1	0.70929424
61	EEF2K	0.68511049
62	CAMK1	0.68254314
63	TAOK2	0.68125619
64	MAPK11	0.67894149
65	RPS6KC1	0.67583492
66	RPS6KL1	0.67583492
67	PHKG2	0.66200657
68	PHKG1	0.66200657
69	DAPK1	0.63952230
70	ERN1	0.63720334
71	CDK7	0.63207224
72	LIMK1	0.59823639
73	NEK2	0.59819784
74	NUAK1	0.59191996
75	TNK2	0.57327286
76	AURKB	0.55974934
77	CSNK2A2	0.55531656
78	CDK19	0.54782282
79	TESK1	0.54635738
80	BMPR1B	0.53209653
81	PLK1	0.52767182
82	CSNK2A1	0.51740558
83	AKT2	0.51584755
84	PRKCG	0.51046526
85	DAPK2	0.49758113
86	RPS6KA2	0.46743045
87	CSNK1A1	0.46560023
88	IRAK2	0.46130635
89	TXK	0.45317233
90	ADRBK1	0.44661489
91	PAK1	0.43383722
92	PKN2	0.43225882
93	GRK6	0.40242711
94	RPS6KA1	0.38316305
95	RPS6KA4	0.38226572
96	CCNB1	0.38114507
97	CAMKK2	0.37933940
98	STK11	0.37829922
99	MINK1	0.37225015
100	EPHB2	0.36823063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.09936517
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.61858076
3	Sulfur relay system_Homo sapiens_hsa04122	3.89841980
4	Parkinsons disease_Homo sapiens_hsa05012	3.75037907
5	RNA polymerase_Homo sapiens_hsa03020	2.91396355
6	DNA replication_Homo sapiens_hsa03030	2.83167677
7	Huntingtons disease_Homo sapiens_hsa05016	2.69699907
8	Base excision repair_Homo sapiens_hsa03410	2.55208663
9	Alzheimers disease_Homo sapiens_hsa05010	2.54152513
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.52171078
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.45194321
12	Proteasome_Homo sapiens_hsa03050	2.15645042
13	Homologous recombination_Homo sapiens_hsa03440	2.02178336
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96941631
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92444371
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.91710156
17	One carbon pool by folate_Homo sapiens_hsa00670	1.85557513
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57301118
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49476782
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.49145330
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.44584465
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.42766107
23	Spliceosome_Homo sapiens_hsa03040	1.34091245
24	Purine metabolism_Homo sapiens_hsa00230	1.30299056
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.28250154
26	Mismatch repair_Homo sapiens_hsa03430	1.27214247
27	Sulfur metabolism_Homo sapiens_hsa00920	1.24003263
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22266794
29	Folate biosynthesis_Homo sapiens_hsa00790	1.12484082
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10951276
31	Protein export_Homo sapiens_hsa03060	1.09509707
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.07186474
33	Alcoholism_Homo sapiens_hsa05034	1.05865188
34	Phototransduction_Homo sapiens_hsa04744	1.04944953
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.00779181
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99456949
37	Metabolic pathways_Homo sapiens_hsa01100	0.98624196
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94088196
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93796776
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93781618
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87244521
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86638257
43	Butanoate metabolism_Homo sapiens_hsa00650	0.85142356
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.83117999
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.80528428
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79380369
47	RNA degradation_Homo sapiens_hsa03018	0.76557390
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75470205
49	Peroxisome_Homo sapiens_hsa04146	0.74465927
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71099056
51	RNA transport_Homo sapiens_hsa03013	0.70691066
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68956004
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67465272
54	Fatty acid elongation_Homo sapiens_hsa00062	0.65982191
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.64676036
56	Glutathione metabolism_Homo sapiens_hsa00480	0.63928466
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.62020852
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.60393692
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59809293
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59518882
61	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.58634357
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55404495
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54196844
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.53783505
65	Basal transcription factors_Homo sapiens_hsa03022	0.51897331
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49488437
67	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48835531
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.47328099
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.44037988
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43628889
71	Carbon metabolism_Homo sapiens_hsa01200	0.42094631
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39629760
73	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37491200
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35228080
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.30975136
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28903436
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.28401001
78	Galactose metabolism_Homo sapiens_hsa00052	0.28089202
79	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.27435078
80	Asthma_Homo sapiens_hsa05310	0.27263926
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26791974
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.26355728
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.25625515
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.23721137
85	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23110299
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22588660
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21943378
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21092433
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20246655
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18570579
91	Pentose phosphate pathway_Homo sapiens_hsa00030	0.18101543
92	Propanoate metabolism_Homo sapiens_hsa00640	0.17385779
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.16604536
94	p53 signaling pathway_Homo sapiens_hsa04115	0.15603721
95	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.15290528
96	Cell cycle_Homo sapiens_hsa04110	0.14784976
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.12458779
98	Lysine degradation_Homo sapiens_hsa00310	0.12034148
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.10804514
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.10742458

MZT2A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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