ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.92507027
2	viral transcription (GO:0019083)	7.77015408
3	translational termination (GO:0006415)	7.18865652
4	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	6.93125656
5	ribosomal small subunit assembly (GO:0000028)	6.44759206
6	translational elongation (GO:0006414)	6.36449733
7	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.15999510
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.06321280
9	protein targeting to ER (GO:0045047)	5.96334741
10	cotranslational protein targeting to membrane (GO:0006613)	5.92036169
11	viral life cycle (GO:0019058)	5.77986603
12	protein localization to endoplasmic reticulum (GO:0070972)	5.68447433
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.67804715
14	maturation of SSU-rRNA (GO:0030490)	5.65047765
15	cellular protein complex disassembly (GO:0043624)	5.59905602
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.51293807
17	pyrimidine nucleotide catabolic process (GO:0006244)	5.21583515
18	protein complex disassembly (GO:0043241)	5.02104434
19	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.69620969
20	translational initiation (GO:0006413)	4.67617943
21	macromolecular complex disassembly (GO:0032984)	4.62498927
22	GTP biosynthetic process (GO:0006183)	4.54468591
23	UTP biosynthetic process (GO:0006228)	4.52402661
24	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.45049422
25	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.32384907
26	guanosine-containing compound biosynthetic process (GO:1901070)	4.29693703
27	protein maturation by protein folding (GO:0022417)	4.29619950
28	protein targeting to membrane (GO:0006612)	4.28656966
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28266366
30	ATP synthesis coupled proton transport (GO:0015986)	4.28266366
31	deoxyribonucleotide catabolic process (GO:0009264)	4.28023778
32	UTP metabolic process (GO:0046051)	4.15920743
33	2-deoxyribonucleotide biosynthetic process (GO:0009265)	4.13573410
34	deoxyribose phosphate biosynthetic process (GO:0046385)	4.13573410
35	chaperone-mediated protein transport (GO:0072321)	4.12074019
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.09770453
37	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.08097860
38	ribonucleoprotein complex biogenesis (GO:0022613)	4.04425436
39	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.95123373
40	deoxyribose phosphate catabolic process (GO:0046386)	3.93425213
41	CTP metabolic process (GO:0046036)	3.93212306
42	CTP biosynthetic process (GO:0006241)	3.93212306
43	regulation of mitochondrial translation (GO:0070129)	3.92841633
44	translation (GO:0006412)	3.88827521
45	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.84175113
46	protein complex biogenesis (GO:0070271)	3.80990832
47	cellular component biogenesis (GO:0044085)	3.75604606
48	GDP-mannose metabolic process (GO:0019673)	3.74908055
49	respiratory electron transport chain (GO:0022904)	3.73916306
50	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.71256659
51	oxidative phosphorylation (GO:0006119)	3.66948486
52	electron transport chain (GO:0022900)	3.65789694
53	UV protection (GO:0009650)	3.58866284
54	proline biosynthetic process (GO:0006561)	3.55273545
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55210136
56	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55210136
57	NADH dehydrogenase complex assembly (GO:0010257)	3.55210136
58	ribosomal large subunit biogenesis (GO:0042273)	3.55104468
59	ncRNA 3-end processing (GO:0043628)	3.52207470
60	protein targeting to mitochondrion (GO:0006626)	3.50642267
61	mitochondrial respiratory chain complex assembly (GO:0033108)	3.50328821
62	base-excision repair, AP site formation (GO:0006285)	3.47043661
63	nucleobase-containing small molecule interconversion (GO:0015949)	3.44508330
64	2-deoxyribonucleotide metabolic process (GO:0009394)	3.44287101
65	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.39366942
66	establishment of protein localization to mitochondrion (GO:0072655)	3.34830451
67	pseudouridine synthesis (GO:0001522)	3.31619168
68	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31112788
69	negative regulation of B cell apoptotic process (GO:0002903)	3.31053275
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.30453984
71	purine deoxyribonucleotide catabolic process (GO:0009155)	3.27697589
72	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.24666015
73	mRNA catabolic process (GO:0006402)	3.22493984
74	iron-sulfur cluster assembly (GO:0016226)	3.22266706
75	metallo-sulfur cluster assembly (GO:0031163)	3.22266706
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.21544643
77	establishment of protein localization to membrane (GO:0090150)	3.21225101
78	pentose metabolic process (GO:0019321)	3.20907797
79	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.16714048
80	deoxyribose phosphate metabolic process (GO:0019692)	3.09100986
81	protein targeting (GO:0006605)	3.07790748
82	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.04428724
83	nucleotide salvage (GO:0043173)	3.03600999
84	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.03099731
85	RNA catabolic process (GO:0006401)	3.01770710
86	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	2.99674122
87	pyrimidine nucleotide metabolic process (GO:0006220)	2.97519664
88	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.97334050
89	cytochrome complex assembly (GO:0017004)	2.91408052
90	ATP biosynthetic process (GO:0006754)	2.91291477
91	negative regulation of cell size (GO:0045792)	2.89574794
92	protein localization to mitochondrion (GO:0070585)	2.89403861
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.80322147
94	rRNA processing (GO:0006364)	2.79260423
95	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.73427547
96	pyrimidine nucleoside biosynthetic process (GO:0046134)	2.71720311
97	protein retention in ER lumen (GO:0006621)	2.71555996
98	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.67887126
99	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.67574796
100	deoxyribonucleotide metabolic process (GO:0009262)	2.66615803

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.46144724
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.10882292
3	VDR_21846776_ChIP-Seq_THP-1_Human	3.04532326
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.76007486
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.62829164
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.59311277
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.56669102
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.40702678
9	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.31227119
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.29718535
11	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.19217677
12	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.10227778
13	XRN2_22483619_ChIP-Seq_HELA_Human	2.05562677
14	MYC_22102868_ChIP-Seq_BL_Human	1.97830185
15	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.97352650
16	P68_20966046_ChIP-Seq_HELA_Human	1.94118942
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.93123495
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90681683
19	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.85156100
20	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.84627840
21	ZNF263_19887448_ChIP-Seq_K562_Human	1.80378432
22	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.74713870
23	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.74304402
24	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.69971309
25	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65595969
26	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.64707001
27	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.62876958
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.62688014
29	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.62271937
30	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.61422045
31	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.56840445
32	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.56279208
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.55898095
34	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53573748
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53530737
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.52192450
37	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.52060788
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49292838
39	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.48281347
40	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.47532882
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.44705379
42	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.43407607
43	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.41981247
44	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.41948525
45	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.41679028
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.38577482
47	KDM2B_26808549_Chip-Seq_DND41_Human	1.37902939
48	BCOR_27268052_Chip-Seq_Bcells_Human	1.37576873
49	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.37528484
50	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.34716967
51	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.34446426
52	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.34165172
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32371664
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.29019142
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28772218
56	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28636602
57	CTCF_27219007_Chip-Seq_Bcells_Human	1.28453580
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.26067955
59	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.25030714
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.24903551
61	MAF_26560356_Chip-Seq_TH2_Human	1.24200776
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.23371790
63	PHF8_20622854_ChIP-Seq_HELA_Human	1.22950512
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22644733
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.22280444
66	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.21344954
67	E2F7_22180533_ChIP-Seq_HELA_Human	1.21090106
68	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.20207097
69	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.20061138
70	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19188112
71	E2F1_20622854_ChIP-Seq_HELA_Human	1.18528213
72	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.18520662
73	VDR_24763502_ChIP-Seq_THP-1_Human	1.17523620
74	SA1_27219007_Chip-Seq_Bcells_Human	1.16750144
75	CTCF_21964334_Chip-Seq_Bcells_Human	1.15701556
76	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15634342
77	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.15010279
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.14185949
79	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.13474523
80	KDM5A_27292631_Chip-Seq_BREAST_Human	1.11097227
81	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.11093584
82	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.10872096
83	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10528882
84	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.10156697
85	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.09762700
86	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.09287608
87	CTCF_20526341_ChIP-Seq_ESCs_Human	1.08868214
88	CREB1_26743006_Chip-Seq_LNCaP_Human	1.07797779
89	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07249538
90	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.04544723
91	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.04429065
92	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.04407641
93	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.03878280
94	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.03413620
95	KDM2B_26808549_Chip-Seq_K562_Human	1.03084491
96	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.01952059
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01867291
98	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01122692
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99517466
100	TP53_22127205_ChIP-Seq_IMR90_Human	0.99509166

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.59531878
2	MP0003123_paternal_imprinting	3.55995278
3	MP0004858_abnormal_nervous_system	2.98366154
4	MP0002163_abnormal_gland_morphology	2.96366066
5	MP0005451_abnormal_body_composition	2.88376815
6	MP0005058_abnormal_lysosome_morphology	2.83972000
7	MP0000678_abnormal_parathyroid_gland	2.82913735
8	MP0002234_abnormal_pharynx_morphology	2.60332853
9	MP0006036_abnormal_mitochondrial_physio	2.53140745
10	MP0004185_abnormal_adipocyte_glucose	2.48105561
11	MP0003186_abnormal_redox_activity	2.36921049
12	MP0009278_abnormal_bone_marrow	2.24850279
13	MP0000681_abnormal_thyroid_gland	2.16457754
14	MP0002249_abnormal_larynx_morphology	2.10762687
15	MP0005670_abnormal_white_adipose	1.98948196
16	MP0002822_catalepsy	1.97005691
17	MP0009840_abnormal_foam_cell	1.92306884
18	MP0006292_abnormal_olfactory_placode	1.92040174
19	MP0009333_abnormal_splenocyte_physiolog	1.69352669
20	MP0005666_abnormal_adipose_tissue	1.63975894
21	MP0005379_endocrine/exocrine_gland_phen	1.62619379
22	MP0001905_abnormal_dopamine_level	1.58574829
23	MP0003806_abnormal_nucleotide_metabolis	1.47220009
24	MP0004859_abnormal_synaptic_plasticity	1.43671025
25	MP0003111_abnormal_nucleus_morphology	1.43640116
26	MP0001545_abnormal_hematopoietic_system	1.42659129
27	MP0005397_hematopoietic_system_phenotyp	1.42659129
28	MP0005375_adipose_tissue_phenotype	1.42494238
29	MP0003786_premature_aging	1.41091558
30	MP0000750_abnormal_muscle_regeneration	1.40433988
31	MP0000003_abnormal_adipose_tissue	1.33566021
32	MP0001188_hyperpigmentation	1.32571984
33	MP0005501_abnormal_skin_physiology	1.32190937
34	MP0000049_abnormal_middle_ear	1.31357977
35	MP0010030_abnormal_orbit_morphology	1.29153012
36	MP0002653_abnormal_ependyma_morphology	1.25264957
37	MP0002877_abnormal_melanocyte_morpholog	1.17833078
38	MP0001661_extended_life_span	1.16182716
39	MP0002160_abnormal_reproductive_system	1.14826031
40	MP0005646_abnormal_pituitary_gland	1.14490524
41	MP0003705_abnormal_hypodermis_morpholog	1.14318030
42	MP0008932_abnormal_embryonic_tissue	1.13739019
43	MP0001873_stomach_inflammation	1.10679299
44	MP0003329_amyloid_beta_deposits	1.07263825
45	MP0003787_abnormal_imprinting	1.05492543
46	MP0003075_altered_response_to	1.01180347
47	MP0008260_abnormal_autophagy	0.99853731
48	MP0001348_abnormal_lacrimal_gland	0.99805898
49	MP0003693_abnormal_embryo_hatching	0.98507502
50	MP0009053_abnormal_anal_canal	0.97494366
51	MP0003303_peritoneal_inflammation	0.96788822
52	MP0003879_abnormal_hair_cell	0.95992612
53	MP0003315_abnormal_perineum_morphology	0.94891729
54	MP0003172_abnormal_lysosome_physiology	0.93513558
55	MP0002089_abnormal_postnatal_growth/wei	0.92057287
56	MP0001764_abnormal_homeostasis	0.86854709
57	MP0002733_abnormal_thermal_nociception	0.84852093
58	MP0000313_abnormal_cell_death	0.82747408
59	MP0004147_increased_porphyrin_level	0.81842050
60	MP0001944_abnormal_pancreas_morphology	0.81463419
61	MP0001663_abnormal_digestive_system	0.81453571
62	MP0001881_abnormal_mammary_gland	0.79585440
63	MP0000759_abnormal_skeletal_muscle	0.79450918
64	MP0003283_abnormal_digestive_organ	0.78878263
65	MP0003942_abnormal_urinary_system	0.78100458
66	MP0006035_abnormal_mitochondrial_morpho	0.76860631
67	MP0005636_abnormal_mineral_homeostasis	0.76773937
68	MP0002132_abnormal_respiratory_system	0.75921359
69	MP0005381_digestive/alimentary_phenotyp	0.75675951
70	MP0005083_abnormal_biliary_tract	0.75632105
71	MP0000343_altered_response_to	0.74248144
72	MP0000490_abnormal_crypts_of	0.73203029
73	MP0001270_distended_abdomen	0.72804319
74	MP0005220_abnormal_exocrine_pancreas	0.72574632
75	MP0001968_abnormal_touch/_nociception	0.70554736
76	MP0003122_maternal_imprinting	0.69618869
77	MP0002736_abnormal_nociception_after	0.68741690
78	MP0005389_reproductive_system_phenotype	0.68451806
79	MP0005330_cardiomyopathy	0.67886228
80	MP0000358_abnormal_cell_content/	0.67876861
81	MP0001919_abnormal_reproductive_system	0.66994086
82	MP0009643_abnormal_urine_homeostasis	0.66070774
83	MP0004233_abnormal_muscle_weight	0.63999782
84	MP0004510_myositis	0.63429722
85	MP0005394_taste/olfaction_phenotype	0.62827720
86	MP0005499_abnormal_olfactory_system	0.62827720
87	MP0001727_abnormal_embryo_implantation	0.62743258
88	MP0000015_abnormal_ear_pigmentation	0.61660300
89	MP0005332_abnormal_amino_acid	0.60788913
90	MP0002837_dystrophic_cardiac_calcinosis	0.60058774
91	MP0005464_abnormal_platelet_physiology	0.59835021
92	MP0004130_abnormal_muscle_cell	0.59554598
93	MP0009384_cardiac_valve_regurgitation	0.59153519
94	MP0005645_abnormal_hypothalamus_physiol	0.58081636
95	MP0003385_abnormal_body_wall	0.57533339
96	MP0000858_altered_metastatic_potential	0.57480649
97	MP0004957_abnormal_blastocyst_morpholog	0.56823926
98	MP0001502_abnormal_circadian_rhythm	0.56772860
99	MP0001970_abnormal_pain_threshold	0.55847901
100	MP0008007_abnormal_cellular_replicative	0.55784634

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.01291893
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.64478498
3	Reticulocytopenia (HP:0001896)	4.60604906
4	Abnormal number of erythroid precursors (HP:0012131)	4.49080388
5	Acute necrotizing encephalopathy (HP:0006965)	4.31954184
6	Mitochondrial inheritance (HP:0001427)	4.20681929
7	Hepatocellular necrosis (HP:0001404)	4.14627353
8	Hyperthyroidism (HP:0000836)	4.14517195
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.01737257
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.00819470
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.00819470
12	Acute encephalopathy (HP:0006846)	3.85257897
13	Hepatic necrosis (HP:0002605)	3.79750243
14	Increased intramyocellular lipid droplets (HP:0012240)	3.75765041
15	Increased muscle lipid content (HP:0009058)	3.74856116
16	Increased CSF lactate (HP:0002490)	3.49073760
17	Broad distal phalanx of finger (HP:0009836)	3.43455169
18	Macrocytic anemia (HP:0001972)	3.34038996
19	Progressive macrocephaly (HP:0004481)	3.27559240
20	Ragged-red muscle fibers (HP:0003200)	3.26506034
21	Microretrognathia (HP:0000308)	3.13090809
22	Pallor (HP:0000980)	3.10374414
23	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.06075950
24	Myokymia (HP:0002411)	2.94820616
25	Truncus arteriosus (HP:0001660)	2.88939035
26	Renal Fanconi syndrome (HP:0001994)	2.88607115
27	Testicular atrophy (HP:0000029)	2.86728977
28	Exercise intolerance (HP:0003546)	2.80260221
29	Microvesicular hepatic steatosis (HP:0001414)	2.79240092
30	Achilles tendon contracture (HP:0001771)	2.73888879
31	Cerebral edema (HP:0002181)	2.73882040
32	Lactic acidosis (HP:0003128)	2.70203747
33	Progressive muscle weakness (HP:0003323)	2.64739203
34	Respiratory failure (HP:0002878)	2.61746581
35	Thrombocytosis (HP:0001894)	2.55591144
36	Visual hallucinations (HP:0002367)	2.55048831
37	Abnormality of reticulocytes (HP:0004312)	2.53835635
38	Hypertensive crisis (HP:0100735)	2.50078422
39	Abnormality of the Achilles tendon (HP:0005109)	2.39725841
40	Increased serum lactate (HP:0002151)	2.38223437
41	Increased hepatocellular lipid droplets (HP:0006565)	2.34723819
42	Hyperparathyroidism (HP:0000843)	2.33430030
43	Lipid accumulation in hepatocytes (HP:0006561)	2.31894815
44	Obstructive lung disease (HP:0006536)	2.28422172
45	Chronic obstructive pulmonary disease (HP:0006510)	2.28422172
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.24734309
47	Double outlet right ventricle (HP:0001719)	2.24475099
48	Congenital malformation of the right heart (HP:0011723)	2.24475099
49	Stridor (HP:0010307)	2.21982114
50	Vertebral compression fractures (HP:0002953)	2.19442910
51	Emotional lability (HP:0000712)	2.19097971
52	Dicarboxylic aciduria (HP:0003215)	2.16321681
53	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.16321681
54	Cerebral palsy (HP:0100021)	2.12934720
55	Myopathic facies (HP:0002058)	2.06746936
56	Muscle stiffness (HP:0003552)	2.05528068
57	Abnormality of the tricuspid valve (HP:0001702)	2.05329062
58	Respiratory difficulties (HP:0002880)	2.02573302
59	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.01555765
60	Prolonged neonatal jaundice (HP:0006579)	2.00573671
61	Progressive microcephaly (HP:0000253)	2.00122359
62	Multiple enchondromatosis (HP:0005701)	1.96704717
63	Petechiae (HP:0000967)	1.96337735
64	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.95439055
65	Opisthotonus (HP:0002179)	1.94298904
66	Agammaglobulinemia (HP:0004432)	1.90435388
67	Neoplasm of head and neck (HP:0012288)	1.90013933
68	Esophageal neoplasm (HP:0100751)	1.90013933
69	Growth hormone excess (HP:0000845)	1.88811219
70	Deep palmar crease (HP:0006191)	1.88274470
71	Rectal prolapse (HP:0002035)	1.85208349
72	Increased serum ferritin (HP:0003281)	1.83057314
73	3-Methylglutaconic aciduria (HP:0003535)	1.82974031
74	Bulbar palsy (HP:0001283)	1.82019650
75	Slender long bone (HP:0003100)	1.79240447
76	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.77499108
77	Hyperacusis (HP:0010780)	1.76977530
78	Thoracic kyphosis (HP:0002942)	1.76021206
79	Exertional dyspnea (HP:0002875)	1.75274348
80	Flat capital femoral epiphysis (HP:0003370)	1.74754740
81	Cellulitis (HP:0100658)	1.74205908
82	Atelectasis (HP:0100750)	1.74076380
83	Seborrheic dermatitis (HP:0001051)	1.73332705
84	Annular pancreas (HP:0001734)	1.73153782
85	Abnormality of the thoracic spine (HP:0100711)	1.73146842
86	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.70854578
87	Patent foramen ovale (HP:0001655)	1.70406450
88	Cleft eyelid (HP:0000625)	1.68481608
89	Hypoplastic left heart (HP:0004383)	1.68431351
90	Increased cerebral lipofuscin (HP:0011813)	1.67633890
91	Abnormal hemoglobin (HP:0011902)	1.67119566
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.66797973
93	Premature skin wrinkling (HP:0100678)	1.66454775
94	Athetosis (HP:0002305)	1.65994659
95	Dysphonia (HP:0001618)	1.65576299
96	Leukodystrophy (HP:0002415)	1.64704827
97	Partial duplication of the phalanx of hand (HP:0009999)	1.62812932
98	Abnormality of magnesium homeostasis (HP:0004921)	1.61507861
99	Rough bone trabeculation (HP:0100670)	1.61473433
100	Hypercalcemia (HP:0003072)	1.60438147

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.99654990
2	ARAF	3.43699917
3	VRK2	3.17599308
4	TRIB3	3.15644387
5	PIM2	3.11783209
6	MAP3K11	3.03963004
7	ERN1	2.95641779
8	IRAK3	2.82212717
9	BCKDK	2.70306124
10	SMG1	2.69247054
11	TESK2	2.37665040
12	TESK1	2.13754596
13	STK16	2.12784169
14	KDR	2.00745078
15	BRAF	2.00643617
16	ABL2	1.82926989
17	ICK	1.82838843
18	SCYL2	1.60286228
19	LRRK2	1.55703071
20	ILK	1.50841871
21	PRKD3	1.46217082
22	SIK1	1.44031084
23	TAOK2	1.42348705
24	PRPF4B	1.34622298
25	TLK1	1.28090673
26	AURKA	1.25529933
27	LIMK1	1.22937626
28	DAPK3	1.22465764
29	RPS6KB2	1.08971960
30	EEF2K	1.07412196
31	MAP2K3	1.07006199
32	BUB1	0.98310658
33	RPS6KL1	0.92444792
34	RPS6KC1	0.92444792
35	IRAK2	0.86785772
36	DAPK1	0.85642599
37	PRKCI	0.83829495
38	MAPKAPK3	0.83686939
39	MAP4K1	0.82969974
40	TAOK1	0.80694668
41	RPS6KA2	0.78506226
42	RPS6KA6	0.76727205
43	RPS6KA5	0.76133903
44	CDK8	0.72977239
45	MAP2K2	0.71861257
46	TTN	0.71178386
47	PKN2	0.70385152
48	MUSK	0.67012865
49	TBK1	0.65958814
50	EPHB2	0.64271108
51	MAPK11	0.63723670
52	PRKD2	0.63422847
53	MAP3K1	0.62864931
54	AKT2	0.62511859
55	CAMKK1	0.61805279
56	MAP3K8	0.61306023
57	HIPK2	0.61229035
58	CAMK2G	0.60793339
59	SIK2	0.60715716
60	CHEK2	0.60299670
61	MARK2	0.60297777
62	DYRK2	0.58919858
63	PDPK1	0.58598569
64	TNK2	0.58059796
65	GRK6	0.57964706
66	PAK1	0.56964589
67	CDC7	0.56521648
68	IKBKB	0.56027769
69	STK4	0.55383837
70	CDK7	0.52813903
71	VRK1	0.52365376
72	MAPK12	0.52007724
73	IRAK4	0.51952970
74	CDK19	0.51401316
75	CDK11A	0.47657476
76	GRK5	0.46472150
77	DMPK	0.45459180
78	MAP2K6	0.42298029
79	AURKB	0.41409881
80	EPHA2	0.41273808
81	CDK15	0.40237368
82	BRSK1	0.39777882
83	MAPK4	0.39491747
84	MTOR	0.39479939
85	CSNK1G3	0.38694503
86	CSNK2A2	0.38079812
87	RAF1	0.37659842
88	CDK14	0.36611238
89	NME1	0.35356400
90	CAMK1	0.34779093
91	ATR	0.33884803
92	CDK4	0.33284420
93	PRKG2	0.32194795
94	RPS6KA1	0.31739348
95	CDK18	0.29359309
96	PKN1	0.29204430
97	CAMK2D	0.29195268
98	PRKCD	0.28881029
99	CSNK2A1	0.28794785
100	MAP3K13	0.28548521

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.93893308
2	Sulfur relay system_Homo sapiens_hsa04122	4.73435052
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.94605460
4	Parkinsons disease_Homo sapiens_hsa05012	3.42910137
5	DNA replication_Homo sapiens_hsa03030	3.09051592
6	Base excision repair_Homo sapiens_hsa03410	2.95265997
7	Huntingtons disease_Homo sapiens_hsa05016	2.50821310
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.49123292
9	Alzheimers disease_Homo sapiens_hsa05010	2.43698270
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.40393806
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.85620306
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84615895
13	RNA polymerase_Homo sapiens_hsa03020	1.83786455
14	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.79268300
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.77949546
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.76133259
17	Pentose phosphate pathway_Homo sapiens_hsa00030	1.73522463
18	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.63173687
19	Folate biosynthesis_Homo sapiens_hsa00790	1.52667699
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52521839
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.49816362
22	Other glycan degradation_Homo sapiens_hsa00511	1.37215347
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.28455649
24	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.27567937
25	Galactose metabolism_Homo sapiens_hsa00052	1.26493596
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.25132687
27	Carbon metabolism_Homo sapiens_hsa01200	1.23340828
28	Fatty acid elongation_Homo sapiens_hsa00062	1.18458433
29	Glutathione metabolism_Homo sapiens_hsa00480	1.14042539
30	Sulfur metabolism_Homo sapiens_hsa00920	1.13913668
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13828214
32	Phenylalanine metabolism_Homo sapiens_hsa00360	1.13290260
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13273946
34	Spliceosome_Homo sapiens_hsa03040	1.08484210
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.05696363
36	Proteasome_Homo sapiens_hsa03050	1.05171959
37	Mismatch repair_Homo sapiens_hsa03430	1.03010485
38	One carbon pool by folate_Homo sapiens_hsa00670	1.00907454
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.00427289
40	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98092089
41	Bladder cancer_Homo sapiens_hsa05219	0.97691210
42	Purine metabolism_Homo sapiens_hsa00230	0.97343940
43	Homologous recombination_Homo sapiens_hsa03440	0.94673622
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.92224880
45	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89399045
46	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.87872458
47	Metabolic pathways_Homo sapiens_hsa01100	0.84669455
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84309483
49	Vibrio cholerae infection_Homo sapiens_hsa05110	0.81801270
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79633125
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74718603
52	VEGF signaling pathway_Homo sapiens_hsa04370	0.73049655
53	Prion diseases_Homo sapiens_hsa05020	0.69927934
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68018298
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.66985698
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65087837
57	Alcoholism_Homo sapiens_hsa05034	0.63711044
58	Notch signaling pathway_Homo sapiens_hsa04330	0.62869010
59	Acute myeloid leukemia_Homo sapiens_hsa05221	0.61314726
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60127318
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.58578020
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.55963720
63	Peroxisome_Homo sapiens_hsa04146	0.53768488
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53437111
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.53271340
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49446814
67	Non-small cell lung cancer_Homo sapiens_hsa05223	0.48159835
68	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45508409
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45239194
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.44063820
71	Lysosome_Homo sapiens_hsa04142	0.40429296
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39839540
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37810860
74	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.33543517
75	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.33232630
76	mTOR signaling pathway_Homo sapiens_hsa04150	0.31476519
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.26314102
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.24824588
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.24370486
80	Salmonella infection_Homo sapiens_hsa05132	0.23892042
81	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.23360397
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.23083723
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.22858209
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.21756008
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.18032593
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.17787340
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17429415
88	HTLV-I infection_Homo sapiens_hsa05166	0.16988021
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.16531455
90	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.16482076
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.14222150
92	Shigellosis_Homo sapiens_hsa05131	0.13806101
93	Pancreatic cancer_Homo sapiens_hsa05212	0.13162632
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.12748231
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.12051883
96	Endocytosis_Homo sapiens_hsa04144	0.09942087
97	Glioma_Homo sapiens_hsa05214	0.09624625
98	RNA transport_Homo sapiens_hsa03013	0.09148483
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.09139271
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.08495162

MZT2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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