N4BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RNA export from nucleus (GO:0046831)5.79049634
2nuclear pore organization (GO:0006999)5.33933306
3nuclear pore complex assembly (GO:0051292)5.25613830
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.07476960
5mitotic sister chromatid cohesion (GO:0007064)5.05104018
6DNA unwinding involved in DNA replication (GO:0006268)4.86626607
7regulation of nucleobase-containing compound transport (GO:0032239)4.49960441
8DNA strand renaturation (GO:0000733)4.42446391
9hippo signaling (GO:0035329)4.34011075
10chromatin remodeling at centromere (GO:0031055)4.28027713
11glucocorticoid receptor signaling pathway (GO:0042921)4.27049184
12pre-miRNA processing (GO:0031054)4.22844153
13DNA double-strand break processing (GO:0000729)4.18302305
14negative regulation of DNA-dependent DNA replication (GO:2000104)4.07536991
15CENP-A containing nucleosome assembly (GO:0034080)4.04591838
16regulation of histone H3-K9 methylation (GO:0051570)3.90314456
17DNA duplex unwinding (GO:0032508)3.87521178
18DNA geometric change (GO:0032392)3.85503620
19protein localization to kinetochore (GO:0034501)3.85129959
20negative regulation of DNA repair (GO:0045738)3.82816221
21replication fork processing (GO:0031297)3.81306902
22pore complex assembly (GO:0046931)3.71781868
23histone exchange (GO:0043486)3.69715348
24monoubiquitinated protein deubiquitination (GO:0035520)3.68912742
25kinetochore organization (GO:0051383)3.65474040
26histone H3-K36 demethylation (GO:0070544)3.61920473
27regulation of DNA endoreduplication (GO:0032875)3.60548782
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.60095664
29negative regulation of histone methylation (GO:0031061)3.56678467
30protein localization to chromosome (GO:0034502)3.55299393
31regulation of centriole replication (GO:0046599)3.54736879
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54702268
33regulation of mitotic spindle checkpoint (GO:1903504)3.54702268
34mitotic chromosome condensation (GO:0007076)3.53556287
35centriole replication (GO:0007099)3.50256304
36negative regulation of thymocyte apoptotic process (GO:0070244)3.48698085
37DNA replication-independent nucleosome assembly (GO:0006336)3.47665145
38DNA replication-independent nucleosome organization (GO:0034724)3.47665145
39corticosteroid receptor signaling pathway (GO:0031958)3.46176555
40DNA replication-dependent nucleosome organization (GO:0034723)3.44312266
41DNA replication-dependent nucleosome assembly (GO:0006335)3.44312266
42protein localization to chromosome, centromeric region (GO:0071459)3.42331075
43mitotic G2/M transition checkpoint (GO:0044818)3.40199001
44sister chromatid segregation (GO:0000819)3.37512390
45germ cell migration (GO:0008354)3.34467171
46resolution of meiotic recombination intermediates (GO:0000712)3.34317741
47definitive hemopoiesis (GO:0060216)3.27408593
48recombinational repair (GO:0000725)3.24264903
49double-strand break repair via homologous recombination (GO:0000724)3.23044566
50protein-DNA complex disassembly (GO:0032986)3.20218684
51nucleosome disassembly (GO:0006337)3.20218684
52regulation of sister chromatid cohesion (GO:0007063)3.19524551
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.19299586
54histone mRNA catabolic process (GO:0071044)3.19126938
55folic acid-containing compound biosynthetic process (GO:0009396)3.18460771
56V(D)J recombination (GO:0033151)3.17073118
57attachment of spindle microtubules to kinetochore (GO:0008608)3.14724522
58regulation of helicase activity (GO:0051095)3.14482417
59postreplication repair (GO:0006301)3.14056437
60metaphase plate congression (GO:0051310)3.13433141
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12269339
62negative regulation of necroptotic process (GO:0060546)3.09892698
63DNA replication checkpoint (GO:0000076)3.09432058
64mitotic nuclear envelope disassembly (GO:0007077)3.09335133
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08459769
66kinetochore assembly (GO:0051382)3.08241224
67interkinetic nuclear migration (GO:0022027)3.07871689
68double-strand break repair via nonhomologous end joining (GO:0006303)3.06152782
69non-recombinational repair (GO:0000726)3.06152782
70DNA conformation change (GO:0071103)3.05146409
71meiotic chromosome segregation (GO:0045132)3.04050425
72mitotic G2 DNA damage checkpoint (GO:0007095)3.03013344
73ATP-dependent chromatin remodeling (GO:0043044)3.02370350
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00453207
75DNA ligation (GO:0006266)2.99956850
76positive regulation of chromosome segregation (GO:0051984)2.99274159
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97197805
78protein prenylation (GO:0018342)2.97146797
79prenylation (GO:0097354)2.97146797
80histone H2A monoubiquitination (GO:0035518)2.96690221
81mitotic metaphase plate congression (GO:0007080)2.95142505
82negative regulation of DNA recombination (GO:0045910)2.94182330
83mitotic spindle checkpoint (GO:0071174)2.94163654
84synapsis (GO:0007129)2.93155960
85somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92517619
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.92517619
87neural tube formation (GO:0001841)2.92442197
88protein K6-linked ubiquitination (GO:0085020)2.91306519
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90427043
90mitotic sister chromatid segregation (GO:0000070)2.89671020
91peptidyl-lysine trimethylation (GO:0018023)2.89110903
92positive regulation of histone H3-K4 methylation (GO:0051571)2.89058751
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88931388
94DNA catabolic process, exonucleolytic (GO:0000738)2.88507465
95intraciliary transport (GO:0042073)2.86824701
96negative regulation of RNA splicing (GO:0033119)2.85405152
97sister chromatid cohesion (GO:0007062)2.83944468
98histone mRNA metabolic process (GO:0008334)2.83473020
99spindle assembly checkpoint (GO:0071173)2.83448000
100regulation of sister chromatid segregation (GO:0033045)2.83067376
101regulation of mitotic sister chromatid separation (GO:0010965)2.83067376
102regulation of mitotic sister chromatid segregation (GO:0033047)2.83067376
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81886011
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.81886011
105regulation of translation, ncRNA-mediated (GO:0045974)2.81886011
106presynaptic membrane assembly (GO:0097105)2.81837194
107response to pheromone (GO:0019236)2.80011072
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79988623
109histone H3-K4 trimethylation (GO:0080182)2.79979409
110histone H3-K4 methylation (GO:0051568)2.79915779
111translesion synthesis (GO:0019985)2.79729731
112reciprocal meiotic recombination (GO:0007131)2.79685498
113reciprocal DNA recombination (GO:0035825)2.79685498
114nuclear envelope disassembly (GO:0051081)2.79477839
115membrane disassembly (GO:0030397)2.79477839
116histone H2A acetylation (GO:0043968)2.79101758
117RNA stabilization (GO:0043489)2.78930277
118mRNA stabilization (GO:0048255)2.78930277
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77993559
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.77008537
121DNA topological change (GO:0006265)2.76976897
122negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.76489310
123regulation of chromosome segregation (GO:0051983)2.76276352
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75267804
125positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75267804
126positive regulation of mitotic sister chromatid separation (GO:1901970)2.75267804
127microtubule anchoring (GO:0034453)2.74905695
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74791009
129pyrimidine nucleobase catabolic process (GO:0006208)2.74765646
130negative regulation of mRNA processing (GO:0050686)2.73667695
131mitotic spindle assembly checkpoint (GO:0007094)2.73520624
132mitotic DNA integrity checkpoint (GO:0044774)2.73285067
133histone lysine demethylation (GO:0070076)2.73026568
134spindle checkpoint (GO:0031577)2.70558646
135positive regulation of mRNA processing (GO:0050685)2.70554934
136regulation of double-strand break repair (GO:2000779)2.70501931
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70418516
138negative regulation of sister chromatid segregation (GO:0033046)2.70418516
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.70418516
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70418516
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.70277081
142negative regulation of chromosome segregation (GO:0051985)2.69674704
143cytoplasmic mRNA processing body assembly (GO:0033962)2.69490665
144histone H3-K9 methylation (GO:0051567)2.68738708
1453-UTR-mediated mRNA stabilization (GO:0070935)2.68484937
146regulation of DNA-dependent DNA replication (GO:0090329)2.67681728
147mitotic recombination (GO:0006312)2.67647606
148DNA strand elongation involved in DNA replication (GO:0006271)2.65836033
149regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.65706944
150intra-S DNA damage checkpoint (GO:0031573)2.60491295
151regulation of gene silencing by RNA (GO:0060966)2.56912685
152regulation of posttranscriptional gene silencing (GO:0060147)2.56912685
153regulation of gene silencing by miRNA (GO:0060964)2.56912685
154DNA damage response, detection of DNA damage (GO:0042769)2.56359690
155microtubule organizing center organization (GO:0031023)2.54914597
156ncRNA catabolic process (GO:0034661)2.54791242
157centrosome organization (GO:0051297)2.54193397
158regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54126349
159regulation of centrosome cycle (GO:0046605)2.54059457
160regulation of centrosome duplication (GO:0010824)2.53750843
161DNA strand elongation (GO:0022616)2.52271513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.87277331
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52918230
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.06951981
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.92026240
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58664895
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.24836069
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23848699
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.20777885
9IGF1R_20145208_ChIP-Seq_DFB_Human2.85851446
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74964142
11ZNF274_21170338_ChIP-Seq_K562_Hela2.66062676
12MYC_22102868_ChIP-Seq_BL_Human2.60630800
13FUS_26573619_Chip-Seq_HEK293_Human2.59656773
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47767192
15TAF15_26573619_Chip-Seq_HEK293_Human2.36245310
16AR_21909140_ChIP-Seq_LNCAP_Human2.36111929
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.29644576
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27039737
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22294634
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20211940
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19438394
22CIITA_25753668_ChIP-Seq_RAJI_Human2.18742376
23GBX2_23144817_ChIP-Seq_PC3_Human2.17294677
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15139720
25* P300_19829295_ChIP-Seq_ESCs_Human2.11979160
26VDR_22108803_ChIP-Seq_LS180_Human2.10659708
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04575170
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.03136187
29E2F7_22180533_ChIP-Seq_HELA_Human11.3978683
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93921006
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.89323895
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85450254
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.85398374
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84887253
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83695657
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.82961903
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.80282448
38SCL_19346495_ChIP-Seq_HPC-7_Human1.79405515
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75147383
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.72366901
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69303581
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66977540
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64583211
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63338289
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59235523
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58531075
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57360229
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54236868
49* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52331130
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51177164
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51151329
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49030919
53* TCF7_22412390_ChIP-Seq_EML_Mouse1.48080098
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46229654
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.45289269
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45139931
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43475038
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39247828
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38456844
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37320813
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36729041
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.36555235
63SMAD4_21799915_ChIP-Seq_A2780_Human1.36211204
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.35953170
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35935207
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35317853
67CBP_20019798_ChIP-Seq_JUKART_Human1.35113616
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35113616
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.34640390
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33301018
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33301018
72ER_23166858_ChIP-Seq_MCF-7_Human1.31022122
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30517823
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28419177
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28319720
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27641181
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.26459214
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26428958
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25927716
80* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25914323
81KDM5A_27292631_Chip-Seq_BREAST_Human1.24106505
82STAT3_23295773_ChIP-Seq_U87_Human1.23735157
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23634396
84FOXP3_21729870_ChIP-Seq_TREG_Human1.22166815
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.21171090
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19610344
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17420576
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16815827
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16693373
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15960981
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15492572
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14985733
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14905871
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14772656
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14354643
96* MYB_26560356_Chip-Seq_TH1_Human1.13618369
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13458894
98* TCF4_23295773_ChIP-Seq_U87_Human1.13265761
99AR_25329375_ChIP-Seq_VCAP_Human1.12862332
100BCAT_22108803_ChIP-Seq_LS180_Human1.12599202
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12558100
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10668211
103RNF2_27304074_Chip-Seq_NSC_Mouse1.10319720
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.10059306
105GATA1_22025678_ChIP-Seq_K562_Human1.09780462
106CHD1_26751641_Chip-Seq_LNCaP_Human1.09070928
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08893829
108* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08622530
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08621974
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08527738
111MYC_18940864_ChIP-ChIP_HL60_Human1.07448572
112TCF4_22108803_ChIP-Seq_LS180_Human1.06992004
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06909151
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06311741
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06173242
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.05651911
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04764403
118XRN2_22483619_ChIP-Seq_HELA_Human1.03779934
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03413441
120UTX_26944678_Chip-Seq_JUKART_Human1.03020185
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02292670
122RUNX2_22187159_ChIP-Seq_PCA_Human1.01244142
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00863468
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00304568
125NANOG_19829295_ChIP-Seq_ESCs_Human0.99362970
126SOX2_19829295_ChIP-Seq_ESCs_Human0.99362970
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98670418
128P53_22387025_ChIP-Seq_ESCs_Mouse0.96180858
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95989626
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95945613
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95840289
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94799946
133* MYB_26560356_Chip-Seq_TH2_Human0.94655093
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.93047688
135ELK1_19687146_ChIP-ChIP_HELA_Human0.92987011
136* TP53_22573176_ChIP-Seq_HFKS_Human0.92866806
137VDR_21846776_ChIP-Seq_THP-1_Human0.92495545
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.92359104
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91617248
140MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91207761
141* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90923359
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89084455
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.89081909
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88866077
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88803297
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88054024
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86582589
148* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86429718
149EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85436100
150MAF_26560356_Chip-Seq_TH1_Human0.85181384
151EWS_26573619_Chip-Seq_HEK293_Human0.85177466
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84072376
153CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83964900
154* VDR_23849224_ChIP-Seq_CD4+_Human0.81150754
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78619893
156TTF2_22483619_ChIP-Seq_HELA_Human0.76669188
157NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76103809
158ISL1_27105846_Chip-Seq_CPCs_Mouse0.74886652
159GABP_19822575_ChIP-Seq_HepG2_Human0.74877010
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.74863280
161POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74264920
162TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74244530
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74146895
164RUNX1_22412390_ChIP-Seq_EML_Mouse0.72883368
165STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.72679165
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72286446
167IRF1_19129219_ChIP-ChIP_H3396_Human0.72055874
168MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71725834
169POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.71551162
170KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70926744
171GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70009966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.67148524
2MP0010094_abnormal_chromosome_stability3.57465848
3MP0000569_abnormal_digit_pigmentation3.38460767
4MP0008057_abnormal_DNA_replication3.32722191
5MP0003123_paternal_imprinting3.21363545
6MP0003121_genomic_imprinting3.05388582
7MP0002396_abnormal_hematopoietic_system2.97640820
8MP0003122_maternal_imprinting2.89343695
9MP0002138_abnormal_hepatobiliary_system2.84406307
10MP0000537_abnormal_urethra_morphology2.76690552
11MP0003077_abnormal_cell_cycle2.68757600
12MP0003111_abnormal_nucleus_morphology2.62615895
13MP0003693_abnormal_embryo_hatching2.49953859
14MP0008058_abnormal_DNA_repair2.17036606
15MP0004808_abnormal_hematopoietic_stem1.94687310
16MP0003890_abnormal_embryonic-extraembry1.87521380
17MP0008007_abnormal_cellular_replicative1.77276143
18MP0001529_abnormal_vocalization1.77086376
19MP0006292_abnormal_olfactory_placode1.75765288
20MP0004957_abnormal_blastocyst_morpholog1.73551370
21MP0002938_white_spotting1.71049606
22MP0003567_abnormal_fetal_cardiomyocyte1.67333225
23MP0006072_abnormal_retinal_apoptosis1.63254530
24MP0003787_abnormal_imprinting1.61683064
25MP0003718_maternal_effect1.60481715
26MP0002009_preneoplasia1.58163746
27MP0000350_abnormal_cell_proliferation1.57676116
28MP0000631_abnormal_neuroendocrine_gland1.57226387
29MP0001672_abnormal_embryogenesis/_devel1.56083873
30MP0005380_embryogenesis_phenotype1.56083873
31MP0004133_heterotaxia1.55911607
32MP0008789_abnormal_olfactory_epithelium1.55759144
33MP0003119_abnormal_digestive_system1.55589052
34MP0003868_abnormal_feces_composition1.53834474
35MP0003984_embryonic_growth_retardation1.52553818
36MP0003136_yellow_coat_color1.52437090
37MP0008877_abnormal_DNA_methylation1.52268608
38MP0005076_abnormal_cell_differentiation1.50843744
39MP0002088_abnormal_embryonic_growth/wei1.50657424
40MP0005394_taste/olfaction_phenotype1.48883991
41MP0005499_abnormal_olfactory_system1.48883991
42MP0002751_abnormal_autonomic_nervous1.48103519
43MP0004264_abnormal_extraembryonic_tissu1.47817623
44MP0003941_abnormal_skin_development1.47296801
45MP0005174_abnormal_tail_pigmentation1.46080008
46MP0003252_abnormal_bile_duct1.43924359
47MP0002877_abnormal_melanocyte_morpholog1.43700677
48MP0010352_gastrointestinal_tract_polyps1.39501279
49MP0001293_anophthalmia1.39457032
50MP0003937_abnormal_limbs/digits/tail_de1.39300187
51MP0002084_abnormal_developmental_patter1.39204274
52MP0001984_abnormal_olfaction1.36422927
53MP0008932_abnormal_embryonic_tissue1.35887674
54MP0001730_embryonic_growth_arrest1.35385674
55MP0004197_abnormal_fetal_growth/weight/1.35259574
56MP0000778_abnormal_nervous_system1.34385256
57MP0009053_abnormal_anal_canal1.33817522
58MP0002086_abnormal_extraembryonic_tissu1.33742581
59MP0001915_intracranial_hemorrhage1.33297566
60MP0008995_early_reproductive_senescence1.33095353
61MP0005551_abnormal_eye_electrophysiolog1.30397265
62MP0005085_abnormal_gallbladder_physiolo1.29195771
63MP0001697_abnormal_embryo_size1.29060247
64MP0001188_hyperpigmentation1.25912779
65MP0003943_abnormal_hepatobiliary_system1.25157077
66MP0010307_abnormal_tumor_latency1.23649576
67MP0005253_abnormal_eye_physiology1.23594519
68MP0002085_abnormal_embryonic_tissue1.23543030
69MP0009703_decreased_birth_body1.21760325
70MP0009672_abnormal_birth_weight1.20015464
71MP0003195_calcinosis1.18868512
72MP0000490_abnormal_crypts_of1.17836485
73MP0000703_abnormal_thymus_morphology1.16993990
74MP0005084_abnormal_gallbladder_morpholo1.16937937
75MP0001929_abnormal_gametogenesis1.13711187
76MP0002102_abnormal_ear_morphology1.13121720
77MP0003763_abnormal_thymus_physiology1.12906242
78MP0000049_abnormal_middle_ear1.10039365
79MP0001485_abnormal_pinna_reflex1.09800211
80MP0009697_abnormal_copulation1.08977784
81MP0002254_reproductive_system_inflammat1.08029614
82MP0002928_abnormal_bile_duct1.07354802
83MP0003935_abnormal_craniofacial_develop1.05867539
84MP0003786_premature_aging1.05146984
85MP0002019_abnormal_tumor_incidence1.04609332
86MP0006276_abnormal_autonomic_nervous1.03550149
87MP0002234_abnormal_pharynx_morphology1.01941482
88MP0002398_abnormal_bone_marrow1.01810214
89MP0003861_abnormal_nervous_system1.01140748
90MP0002080_prenatal_lethality1.01116091
91MP0001177_atelectasis1.00222515
92MP0009278_abnormal_bone_marrow0.99860352
93MP0003880_abnormal_central_pattern0.99370536
94MP0000313_abnormal_cell_death0.98819827
95MP0005391_vision/eye_phenotype0.98783536
96MP0010030_abnormal_orbit_morphology0.98230689
97MP0005075_abnormal_melanosome_morpholog0.97649692
98MP0001286_abnormal_eye_development0.96578629
99MP0000647_abnormal_sebaceous_gland0.96121391
100MP0000427_abnormal_hair_cycle0.94813249
101MP0000428_abnormal_craniofacial_morphol0.94546717
102MP0001145_abnormal_male_reproductive0.94046108
103MP0000653_abnormal_sex_gland0.94043419
104MP0002736_abnormal_nociception_after0.93101761
105MP0002249_abnormal_larynx_morphology0.90802924
106MP0003942_abnormal_urinary_system0.90259915
107MP0002932_abnormal_joint_morphology0.90034711
108MP0002092_abnormal_eye_morphology0.88348555
109MP0005187_abnormal_penis_morphology0.88076343
110MP0005248_abnormal_Harderian_gland0.88018920
111MP0003698_abnormal_male_reproductive0.87879029
112MP0002233_abnormal_nose_morphology0.87512258
113MP0000566_synostosis0.87449703
114MP0003385_abnormal_body_wall0.87274247
115MP0000516_abnormal_urinary_system0.87016500
116MP0005367_renal/urinary_system_phenotyp0.87016500
117MP0002925_abnormal_cardiovascular_devel0.85009630
118MP0000432_abnormal_head_morphology0.83189560
119MP0001119_abnormal_female_reproductive0.82604266
120MP0005645_abnormal_hypothalamus_physiol0.82389799
121MP0002163_abnormal_gland_morphology0.80982704
122MP0000689_abnormal_spleen_morphology0.80716688
123MP0005195_abnormal_posterior_eye0.80550593
124MP0005397_hematopoietic_system_phenotyp0.80281118
125MP0001545_abnormal_hematopoietic_system0.80281118
126MP0005365_abnormal_bile_salt0.80280867
127MP0003755_abnormal_palate_morphology0.79985851
128MP0002722_abnormal_immune_system0.78814744
129MP0002697_abnormal_eye_size0.78252947
130MP0001299_abnormal_eye_distance/0.77370685
131MP0003300_gastrointestinal_ulcer0.75351251
132MP0003938_abnormal_ear_development0.74319548
133MP0006054_spinal_hemorrhage0.74088856
134MP0002111_abnormal_tail_morphology0.73779496
135MP0000372_irregular_coat_pigmentation0.73743375
136MP0001324_abnormal_eye_pigmentation0.73103971
137MP0001986_abnormal_taste_sensitivity0.72824080
138MP0002638_abnormal_pupillary_reflex0.72196411
139MP0002095_abnormal_skin_pigmentation0.70621790
140MP0003221_abnormal_cardiomyocyte_apopto0.69673835
141MP0002210_abnormal_sex_determination0.68665220
142MP0004147_increased_porphyrin_level0.68222895
143MP0002282_abnormal_trachea_morphology0.68143676
144MP0000733_abnormal_muscle_development0.67896962
145MP0010368_abnormal_lymphatic_system0.67028464
146MP0000383_abnormal_hair_follicle0.66920678
147MP0002116_abnormal_craniofacial_bone0.66677459

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.27979973
2Abnormality of the fingertips (HP:0001211)3.72621690
3Abnormal number of incisors (HP:0011064)3.64531008
4Selective tooth agenesis (HP:0001592)3.60470362
5Short 4th metacarpal (HP:0010044)3.53932828
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53932828
7Intestinal atresia (HP:0011100)3.28016943
8Abnormal biliary tract physiology (HP:0012439)3.25586964
9Bile duct proliferation (HP:0001408)3.25586964
10Abnormality of chromosome stability (HP:0003220)3.12216232
11Subacute progressive viral hepatitis (HP:0006572)3.12083447
12Prominent nose (HP:0000448)3.10677874
13Supernumerary spleens (HP:0009799)3.03551068
14Midline defect of the nose (HP:0004122)2.97379647
15Increased nuchal translucency (HP:0010880)2.96491121
16Intrahepatic cholestasis (HP:0001406)2.91024912
17IgM deficiency (HP:0002850)2.86471044
18Medulloblastoma (HP:0002885)2.79388869
19Ectopic kidney (HP:0000086)2.70076558
20Septo-optic dysplasia (HP:0100842)2.69465575
21Pancreatic cysts (HP:0001737)2.68348507
22Chromsome breakage (HP:0040012)2.65695495
23Abnormality of the phalanges of the hallux (HP:0010057)2.64911673
24Acute myeloid leukemia (HP:0004808)2.63973664
25High pitched voice (HP:0001620)2.63080548
26Pancreatic fibrosis (HP:0100732)2.55684738
27Abnormality of the 4th metacarpal (HP:0010012)2.52569138
28Truncal obesity (HP:0001956)2.51405280
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49596593
30Colon cancer (HP:0003003)2.46909372
31Papillary thyroid carcinoma (HP:0002895)2.45326395
32Rhabdomyosarcoma (HP:0002859)2.43622134
33Nephronophthisis (HP:0000090)2.40037688
34Heterotopia (HP:0002282)2.38498704
35Long eyelashes (HP:0000527)2.36960804
36Aqueductal stenosis (HP:0002410)2.36462351
37True hermaphroditism (HP:0010459)2.30180704
38Hyperglycinemia (HP:0002154)2.29961557
39Chronic hepatic failure (HP:0100626)2.29189767
40Neoplasm of the oral cavity (HP:0100649)2.28858819
41Genital tract atresia (HP:0001827)2.27406645
42Ependymoma (HP:0002888)2.27335400
43Cutis marmorata (HP:0000965)2.26691925
44Increased number of teeth (HP:0011069)2.25956232
45Oligodactyly (hands) (HP:0001180)2.25608504
46Gastrointestinal atresia (HP:0002589)2.25434674
47Stenosis of the external auditory canal (HP:0000402)2.24921296
48Abnormality of midbrain morphology (HP:0002418)2.23850089
49Molar tooth sign on MRI (HP:0002419)2.23850089
50Neoplasm of the small intestine (HP:0100833)2.22794291
51Macroorchidism (HP:0000053)2.22273577
52Acute lymphatic leukemia (HP:0006721)2.22200436
53Obsessive-compulsive behavior (HP:0000722)2.21871151
54Drooling (HP:0002307)2.19966992
55Hyperventilation (HP:0002883)2.18542135
56Viral hepatitis (HP:0006562)2.17788312
57Hypochromic microcytic anemia (HP:0004840)2.17724616
58Azoospermia (HP:0000027)2.16211628
59Birth length less than 3rd percentile (HP:0003561)2.15627445
60Medial flaring of the eyebrow (HP:0010747)2.15380332
61Broad palm (HP:0001169)2.14710948
62Abnormality of the incisor (HP:0000676)2.14252908
63Abnormality of the intervertebral disk (HP:0005108)2.14175979
64Proximal placement of thumb (HP:0009623)2.13779088
65Vaginal atresia (HP:0000148)2.13471303
66Abnormality of the duodenum (HP:0002246)2.12279480
67Squamous cell carcinoma (HP:0002860)2.11545801
68Deviation of the thumb (HP:0009603)2.10743677
69Renal cortical cysts (HP:0000803)2.10285121
70Optic nerve hypoplasia (HP:0000609)2.09962299
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.09053102
72Abnormality of the renal medulla (HP:0100957)2.07574644
73Sloping forehead (HP:0000340)2.07138827
74Neoplasm of striated muscle (HP:0009728)2.05731854
75Abnormality of the septum pellucidum (HP:0007375)2.05046753
76Astrocytoma (HP:0009592)2.04733987
77Abnormality of the astrocytes (HP:0100707)2.04733987
78Smooth philtrum (HP:0000319)2.03026634
79Abnormality of the preputium (HP:0100587)2.02362427
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02260834
81Neoplasm of the adrenal cortex (HP:0100641)2.01902774
82Small intestinal stenosis (HP:0012848)2.01835378
83Duodenal stenosis (HP:0100867)2.01835378
84Gonadotropin excess (HP:0000837)2.00273042
85Deep philtrum (HP:0002002)1.99309960
86Abnormal lung lobation (HP:0002101)1.99137989
87Bifid tongue (HP:0010297)1.98758486
88Impulsivity (HP:0100710)1.97788649
89Abnormality of monocarboxylic acid metabolism (HP:0010996)1.97694524
90Abolished electroretinogram (ERG) (HP:0000550)1.97131115
91Abnormal hair whorl (HP:0010721)1.95703755
92Excessive salivation (HP:0003781)1.95094582
93Congenital primary aphakia (HP:0007707)1.94889061
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.94466876
95Meckel diverticulum (HP:0002245)1.94050356
96Absent septum pellucidum (HP:0001331)1.93914451
97Abnormal spermatogenesis (HP:0008669)1.93105718
98Short tibia (HP:0005736)1.92149426
99Gait imbalance (HP:0002141)1.91095678
100Sacral dimple (HP:0000960)1.89863341
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.89861959
102Clubbing of toes (HP:0100760)1.89660028
103Abnormality of the renal cortex (HP:0011035)1.88825383
104Abnormality of homocysteine metabolism (HP:0010919)1.88360753
105Homocystinuria (HP:0002156)1.88360753
106Nephroblastoma (Wilms tumor) (HP:0002667)1.87776328
107Dandy-Walker malformation (HP:0001305)1.86307493
108Absent radius (HP:0003974)1.86233081
109Exostoses (HP:0100777)1.84905726
110Glioma (HP:0009733)1.84652479
111Anophthalmia (HP:0000528)1.84277340
112Embryonal neoplasm (HP:0002898)1.84014423
113Methylmalonic acidemia (HP:0002912)1.83665604
114Abnormality of the ileum (HP:0001549)1.83155898
115Preaxial hand polydactyly (HP:0001177)1.82342591
116Nephrogenic diabetes insipidus (HP:0009806)1.82272961
117Triphalangeal thumb (HP:0001199)1.81927122
118Abnormality of the labia minora (HP:0012880)1.81418593
119Myelodysplasia (HP:0002863)1.81342074
120IgA deficiency (HP:0002720)1.81163154
121Cafe-au-lait spot (HP:0000957)1.80451846
122Labial hypoplasia (HP:0000066)1.80277885
123Absent forearm bone (HP:0003953)1.80270361
124Aplasia involving forearm bones (HP:0009822)1.80270361
125Renal hypoplasia (HP:0000089)1.79406618
126Postaxial foot polydactyly (HP:0001830)1.79096714
127Abnormality of chromosome segregation (HP:0002916)1.79084185
128Atresia of the external auditory canal (HP:0000413)1.78883821
129Renal duplication (HP:0000075)1.77556097
130Facial hemangioma (HP:0000329)1.77311580
131Hepatoblastoma (HP:0002884)1.77204042
132Recurrent viral infections (HP:0004429)1.76620237
133Aplastic anemia (HP:0001915)1.76098565
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.75770737
135Pancreatic islet-cell hyperplasia (HP:0004510)1.75470823
136Embryonal renal neoplasm (HP:0011794)1.74925512
137Broad thumb (HP:0011304)1.74171648
138Gastrointestinal carcinoma (HP:0002672)1.73531346
139Malignant gastrointestinal tract tumors (HP:0006749)1.73531346
140Renovascular hypertension (HP:0100817)1.72779134
141Abnormality of the clitoris (HP:0000056)1.72494982
142Amaurosis fugax (HP:0100576)1.72492488
143Methylmalonic aciduria (HP:0012120)1.72231063
144Growth hormone deficiency (HP:0000824)1.71521221
145Hypoplastic female external genitalia (HP:0012815)1.71402357
146Thyroid carcinoma (HP:0002890)1.71194723
147Low anterior hairline (HP:0000294)1.71169992
148Hemivertebrae (HP:0002937)1.70658949
149Neoplasm of the rectum (HP:0100743)1.70652506
150Biliary tract neoplasm (HP:0100574)1.70446256
151Patellar aplasia (HP:0006443)1.69991554
152Poor coordination (HP:0002370)1.69517626
153Abnormality of the carotid arteries (HP:0005344)1.69495288
154Micropenis (HP:0000054)1.69034187
155Hepatocellular carcinoma (HP:0001402)1.68844413
156Clitoromegaly (HP:0000057)1.68733794
157Syringomyelia (HP:0003396)1.68584447
158Spinal cord lesions (HP:0100561)1.68584447
159Cortical dysplasia (HP:0002539)1.68436651
160Lissencephaly (HP:0001339)1.68382685
161Synophrys (HP:0000664)1.68340437
162Small hand (HP:0200055)1.68096536
163Neoplasm of the liver (HP:0002896)1.67684703
164Broad foot (HP:0001769)1.67376104
165Thyroiditis (HP:0100646)1.66984063
166Cupped ear (HP:0000378)1.66851078
167Tubulointerstitial nephritis (HP:0001970)1.66798699
168Trigonocephaly (HP:0000243)1.66210866
169Postaxial hand polydactyly (HP:0001162)1.66077744
170Limited elbow extension (HP:0001377)1.65866923
171Increased density of long bones (HP:0006392)1.65606854
172Esophageal atresia (HP:0002032)1.65142631
173Blepharitis (HP:0000498)1.65060238
174Broad-based gait (HP:0002136)1.64882908
175Stomach cancer (HP:0012126)1.64551662
176Protruding tongue (HP:0010808)1.64087231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK36.37322915
2STK244.43828791
3CDC73.68461197
4WNK33.16103854
5CDK122.94946139
6TNIK2.87997122
7MAP3K102.86612209
8TTK2.80048768
9TRIM282.72311659
10LATS12.50978517
11CASK2.31762238
12NEK22.31725134
13MAP3K42.26485090
14MAP4K22.15079384
15BCR2.11186783
16BMPR1B2.04334345
17STK102.02288546
18PKN21.99076459
19CDK41.95974499
20SRPK11.92679593
21BRD41.78755171
22PLK41.70231315
23CDK61.67797223
24EEF2K1.61817209
25EIF2AK31.58724073
26ATR1.56468626
27PTK61.53800100
28MKNK21.48603965
29ACVR1B1.48024843
30MKNK11.44989017
31MATK1.38790821
32PLK31.38081689
33TSSK61.36787900
34TAF11.35010010
35STK41.33556406
36EPHA31.32698726
37CDK191.24053669
38CHEK11.23331856
39NUAK11.23237510
40ATM1.20231478
41PLK11.20195802
42KIT1.19734586
43NEK11.16274842
44MST41.15892250
45WEE11.15338422
46CHEK21.13092332
47FLT31.11416454
48MAP2K71.11342904
49MAPK131.09086253
50DYRK21.07909849
51RPS6KB21.07315564
52TEC1.04363844
53CDK91.02697503
54CSNK1G20.98595927
55MTOR0.98260382
56LATS20.95333866
57BRSK20.94002869
58CDK70.92986020
59ALK0.92811105
60MELK0.92510589
61FGFR10.90768682
62CAMK1G0.90219709
63CDK20.88468463
64INSRR0.88042194
65AKT30.88021574
66AURKB0.87108641
67TGFBR10.85989658
68DYRK30.85926880
69PIM10.84489350
70CAMK1D0.83525658
71FGFR30.82828275
72MAP3K60.82192606
73GRK10.81880250
74TIE10.81441549
75PASK0.80276838
76PBK0.79608201
77MARK10.79316622
78MAP3K80.76996250
79TAOK30.75679631
80OXSR10.74126362
81PLK20.73870074
82FGFR20.73010421
83DMPK0.70409081
84FGFR40.69634142
85BTK0.67283988
86CDK10.66833545
87STK38L0.66114966
88RPS6KA40.65400982
89ZAK0.64498197
90MAP4K10.62888551
91NLK0.61765665
92CSNK1A1L0.59942973
93MAPK140.59606854
94STK390.59352297
95GRK60.56661955
96PRKCE0.55559647
97VRK10.54871890
98DYRK1A0.53876601
99CHUK0.52826400
100YES10.52712439
101CSNK1G10.51764918
102LRRK20.51630099
103CDK80.50786722
104VRK20.50747568
105PRKCG0.50655642
106ADRBK20.50538168
107SGK30.49726397
108CLK10.49486652
109WNK40.47638845
110CSNK1D0.46888140
111MINK10.45609582
112PAK30.45584168
113EPHA40.45471677
114MAPK10.42765923
115GSK3B0.41783107
116JAK30.41137026
117PNCK0.39579910
118MAP3K70.38977178
119ERBB30.38378234
120AKT10.38227076
121SGK20.38052685
122WNK10.37876872
123STK160.36782490
124CSNK2A10.35524713
125RPS6KA50.35370639
126PRKDC0.35356528
127RPS6KB10.34908231
128PINK10.34338121
129MAPK100.34064339
130NEK90.33708271
131CSNK1G30.33179749
132EIF2AK10.32875962
133NTRK20.32088511
134CSF1R0.31646309
135TLK10.31523455
136PRKACB0.31445179
137EGFR0.30233410
138EIF2AK20.29493120
139BUB10.28707751
140TYK20.27781519
141CSNK1E0.27709058
142CDK30.26554993
143MAPK90.25479654
144MAPK80.24813258
145FRK0.24756418

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.38834205
2One carbon pool by folate_Homo sapiens_hsa006703.01614152
3DNA replication_Homo sapiens_hsa030302.87434388
4Fanconi anemia pathway_Homo sapiens_hsa034602.80859170
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78001213
6Steroid biosynthesis_Homo sapiens_hsa001002.65451551
7Mismatch repair_Homo sapiens_hsa034302.59440974
8Protein export_Homo sapiens_hsa030602.52365771
9Non-homologous end-joining_Homo sapiens_hsa034502.51494542
10Homologous recombination_Homo sapiens_hsa034402.46375054
11Lysine degradation_Homo sapiens_hsa003102.22894073
12Propanoate metabolism_Homo sapiens_hsa006402.19449518
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18397237
14mRNA surveillance pathway_Homo sapiens_hsa030152.16364162
15Spliceosome_Homo sapiens_hsa030402.12715457
16Base excision repair_Homo sapiens_hsa034102.08368394
17RNA transport_Homo sapiens_hsa030132.06912207
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76041122
19RNA degradation_Homo sapiens_hsa030181.73875145
20Colorectal cancer_Homo sapiens_hsa052101.71032186
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64236649
22Phototransduction_Homo sapiens_hsa047441.52828453
23Small cell lung cancer_Homo sapiens_hsa052221.52218956
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51865795
25Basal cell carcinoma_Homo sapiens_hsa052171.51343902
26MicroRNAs in cancer_Homo sapiens_hsa052061.50539653
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49376496
28Viral carcinogenesis_Homo sapiens_hsa052031.44458006
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44179385
30Chronic myeloid leukemia_Homo sapiens_hsa052201.43219168
31Hippo signaling pathway_Homo sapiens_hsa043901.42859617
32Nicotine addiction_Homo sapiens_hsa050331.42353344
33Butanoate metabolism_Homo sapiens_hsa006501.40669697
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40629543
35Basal transcription factors_Homo sapiens_hsa030221.40154258
36Primary immunodeficiency_Homo sapiens_hsa053401.39817985
37Herpes simplex infection_Homo sapiens_hsa051681.38568378
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37140541
39Selenocompound metabolism_Homo sapiens_hsa004501.33537961
40p53 signaling pathway_Homo sapiens_hsa041151.31877586
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.31536875
42Endometrial cancer_Homo sapiens_hsa052131.30247629
43Nucleotide excision repair_Homo sapiens_hsa034201.28758265
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.27796018
45Systemic lupus erythematosus_Homo sapiens_hsa053221.22826083
46Proteasome_Homo sapiens_hsa030501.22241391
47Acute myeloid leukemia_Homo sapiens_hsa052211.13682567
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07874873
49HTLV-I infection_Homo sapiens_hsa051661.07467264
50B cell receptor signaling pathway_Homo sapiens_hsa046621.06832413
51Hepatitis B_Homo sapiens_hsa051611.06632257
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05601998
53Nitrogen metabolism_Homo sapiens_hsa009101.03600199
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02884863
55Prostate cancer_Homo sapiens_hsa052151.02327249
56TGF-beta signaling pathway_Homo sapiens_hsa043501.02022859
57Epstein-Barr virus infection_Homo sapiens_hsa051691.01443909
58Non-small cell lung cancer_Homo sapiens_hsa052230.98518990
59RNA polymerase_Homo sapiens_hsa030200.95970288
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94655933
61Pancreatic cancer_Homo sapiens_hsa052120.94120359
62FoxO signaling pathway_Homo sapiens_hsa040680.93743026
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.93687971
64Taste transduction_Homo sapiens_hsa047420.93621819
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92934329
66Oocyte meiosis_Homo sapiens_hsa041140.87761269
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87496205
68Regulation of autophagy_Homo sapiens_hsa041400.87223224
69Pyrimidine metabolism_Homo sapiens_hsa002400.85926575
70Peroxisome_Homo sapiens_hsa041460.85519092
71Pathways in cancer_Homo sapiens_hsa052000.85127784
72Wnt signaling pathway_Homo sapiens_hsa043100.84870570
73Notch signaling pathway_Homo sapiens_hsa043300.81568690
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81310569
75Adherens junction_Homo sapiens_hsa045200.80460765
76Antigen processing and presentation_Homo sapiens_hsa046120.79116430
77Caffeine metabolism_Homo sapiens_hsa002320.78633572
78Measles_Homo sapiens_hsa051620.75917552
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75823400
80ABC transporters_Homo sapiens_hsa020100.75652312
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74466473
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73282870
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.73227823
84Huntingtons disease_Homo sapiens_hsa050160.73203926
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72669748
86Viral myocarditis_Homo sapiens_hsa054160.72103237
87Toxoplasmosis_Homo sapiens_hsa051450.71953746
88Ether lipid metabolism_Homo sapiens_hsa005650.71792138
89Oxidative phosphorylation_Homo sapiens_hsa001900.71656269
90Linoleic acid metabolism_Homo sapiens_hsa005910.69142126
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68702671
92Thyroid cancer_Homo sapiens_hsa052160.68358771
93Parkinsons disease_Homo sapiens_hsa050120.68047950
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.66484372
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65571858
96Hematopoietic cell lineage_Homo sapiens_hsa046400.65129428
97Hedgehog signaling pathway_Homo sapiens_hsa043400.60068319
98Proteoglycans in cancer_Homo sapiens_hsa052050.59077457
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59065992
100Vitamin B6 metabolism_Homo sapiens_hsa007500.58547746
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.58057791
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57271840
103Fatty acid metabolism_Homo sapiens_hsa012120.57028996
104T cell receptor signaling pathway_Homo sapiens_hsa046600.56053960
105Apoptosis_Homo sapiens_hsa042100.55724662
106Complement and coagulation cascades_Homo sapiens_hsa046100.54746476
107Olfactory transduction_Homo sapiens_hsa047400.54516339
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.53600766
109Fat digestion and absorption_Homo sapiens_hsa049750.50047729
110Fatty acid elongation_Homo sapiens_hsa000620.48200633
111Vitamin digestion and absorption_Homo sapiens_hsa049770.47457592
112Retinol metabolism_Homo sapiens_hsa008300.47311230
113Influenza A_Homo sapiens_hsa051640.47119991
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.46699112
115TNF signaling pathway_Homo sapiens_hsa046680.45732486
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43468384
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.42895845
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42577330
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.42112069
120mTOR signaling pathway_Homo sapiens_hsa041500.41829147
121Insulin resistance_Homo sapiens_hsa049310.41543770
122beta-Alanine metabolism_Homo sapiens_hsa004100.41248622
123Metabolic pathways_Homo sapiens_hsa011000.40543346
124Choline metabolism in cancer_Homo sapiens_hsa052310.40157451
125N-Glycan biosynthesis_Homo sapiens_hsa005100.39924033
126Pyruvate metabolism_Homo sapiens_hsa006200.39723795
127Prolactin signaling pathway_Homo sapiens_hsa049170.39370036
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36797577
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35833703
130Dorso-ventral axis formation_Homo sapiens_hsa043200.35695366
131Hepatitis C_Homo sapiens_hsa051600.35191486
132Purine metabolism_Homo sapiens_hsa002300.35171221
133Alcoholism_Homo sapiens_hsa050340.35029008
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34344460
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34315066
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34009140
137Tryptophan metabolism_Homo sapiens_hsa003800.33910888
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33557551
139Tight junction_Homo sapiens_hsa045300.33309294
140GABAergic synapse_Homo sapiens_hsa047270.32818843
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32037299
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30214774
143Osteoclast differentiation_Homo sapiens_hsa043800.29768591
144Serotonergic synapse_Homo sapiens_hsa047260.29547134
145Platelet activation_Homo sapiens_hsa046110.28810404
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26656833
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26609282
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23159119
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23143994
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22734487
151Circadian rhythm_Homo sapiens_hsa047100.22297061
152Glutamatergic synapse_Homo sapiens_hsa047240.21714873
153Melanoma_Homo sapiens_hsa052180.21246520
154Dopaminergic synapse_Homo sapiens_hsa047280.20233178

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