N6AMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.31606171
2protein complex biogenesis (GO:0070271)4.71276040
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62624182
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.62624182
5NADH dehydrogenase complex assembly (GO:0010257)4.62624182
6cilium or flagellum-dependent cell motility (GO:0001539)4.38399774
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30922557
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21492503
9ATP synthesis coupled proton transport (GO:0015986)4.21492503
10respiratory electron transport chain (GO:0022904)4.14492920
11electron transport chain (GO:0022900)4.03368054
12daunorubicin metabolic process (GO:0044597)4.01364172
13polyketide metabolic process (GO:0030638)4.01364172
14doxorubicin metabolic process (GO:0044598)4.01364172
15mitochondrial respiratory chain complex assembly (GO:0033108)3.99440709
16intraciliary transport (GO:0042073)3.97393737
17mannosylation (GO:0097502)3.81450681
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67964228
19positive regulation of protein homodimerization activity (GO:0090073)3.57500928
20proteasome assembly (GO:0043248)3.53267778
21termination of RNA polymerase III transcription (GO:0006386)3.47706921
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.47706921
23cilium movement (GO:0003341)3.41374488
24respiratory chain complex IV assembly (GO:0008535)3.40921332
25behavioral response to ethanol (GO:0048149)3.40674580
26dopamine transport (GO:0015872)3.38975996
27presynaptic membrane assembly (GO:0097105)3.37956243
28cytochrome complex assembly (GO:0017004)3.37365508
29regulation of mitochondrial translation (GO:0070129)3.33640283
30DNA double-strand break processing (GO:0000729)3.29013052
31epithelial cilium movement (GO:0003351)3.27618735
32photoreceptor cell maintenance (GO:0045494)3.22546327
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22394106
34presynaptic membrane organization (GO:0097090)3.19072012
35signal peptide processing (GO:0006465)3.16800226
36L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15639780
37superoxide anion generation (GO:0042554)3.14985919
38protein neddylation (GO:0045116)3.14315739
39cilium morphogenesis (GO:0060271)3.10308699
40neuron cell-cell adhesion (GO:0007158)3.08517407
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07877024
42chaperone-mediated protein transport (GO:0072321)3.07728401
43resolution of meiotic recombination intermediates (GO:0000712)3.07133560
44cilium organization (GO:0044782)2.98340211
45regulation of cilium movement (GO:0003352)2.97464062
46nucleotide transmembrane transport (GO:1901679)2.96038340
47cilium assembly (GO:0042384)2.94917583
48GPI anchor biosynthetic process (GO:0006506)2.94144618
49nonmotile primary cilium assembly (GO:0035058)2.94101907
50synapsis (GO:0007129)2.93350369
51axoneme assembly (GO:0035082)2.92675976
52reciprocal DNA recombination (GO:0035825)2.88695096
53reciprocal meiotic recombination (GO:0007131)2.88695096
54cell differentiation involved in metanephros development (GO:0072202)2.87456390
55axonemal dynein complex assembly (GO:0070286)2.81803561
56positive regulation of male gonad development (GO:2000020)2.79247389
57UDP-N-acetylglucosamine metabolic process (GO:0006047)2.77397192
58developmental pigmentation (GO:0048066)2.74711275
59eosinophil chemotaxis (GO:0048245)2.74652057
60hydrogen ion transmembrane transport (GO:1902600)2.74098021
61branched-chain amino acid catabolic process (GO:0009083)2.73956322
62negative regulation of myoblast differentiation (GO:0045662)2.72890595
63detection of calcium ion (GO:0005513)2.72601946
64postsynaptic membrane organization (GO:0001941)2.72277463
65double-strand break repair via nonhomologous end joining (GO:0006303)2.71940555
66non-recombinational repair (GO:0000726)2.71940555
67RNA capping (GO:0036260)2.71723173
687-methylguanosine RNA capping (GO:0009452)2.71723173
697-methylguanosine mRNA capping (GO:0006370)2.71547468
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70164231
71somatic hypermutation of immunoglobulin genes (GO:0016446)2.70164231
72glycoside metabolic process (GO:0016137)2.69745077
73protein prenylation (GO:0018342)2.69487991
74prenylation (GO:0097354)2.69487991
75monoubiquitinated protein deubiquitination (GO:0035520)2.68836196
76regulation of male gonad development (GO:2000018)2.67526323
77DNA deamination (GO:0045006)2.67152398
78inner mitochondrial membrane organization (GO:0007007)2.65709949
79aminoglycoside antibiotic metabolic process (GO:0030647)2.62100091
80response to nitrosative stress (GO:0051409)2.61549470
81nucleoside diphosphate catabolic process (GO:0009134)2.61368959
82GPI anchor metabolic process (GO:0006505)2.60130412
83mesenchymal cell differentiation involved in renal system development (GO:2001012)2.60119981
84mesenchymal cell differentiation involved in kidney development (GO:0072161)2.60119981
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59351209
86peptidyl-histidine modification (GO:0018202)2.57432623
87proton transport (GO:0015992)2.57324123
88seminiferous tubule development (GO:0072520)2.56657599
89kynurenine metabolic process (GO:0070189)2.56126081
90replication fork processing (GO:0031297)2.55397035
91positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.54843484
92amino acid salvage (GO:0043102)2.54689383
93L-methionine salvage (GO:0071267)2.54689383
94L-methionine biosynthetic process (GO:0071265)2.54689383
95biotin metabolic process (GO:0006768)2.53222576
96indole-containing compound catabolic process (GO:0042436)2.52520032
97indolalkylamine catabolic process (GO:0046218)2.52520032
98tryptophan catabolic process (GO:0006569)2.52520032
99regulation of helicase activity (GO:0051095)2.52373447
100hydrogen transport (GO:0006818)2.49797718
101cellular component assembly involved in morphogenesis (GO:0010927)2.49462575
102deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.48506342
103transcription elongation from RNA polymerase I promoter (GO:0006362)2.47842900
104double-strand break repair via homologous recombination (GO:0000724)2.47563988
105recombinational repair (GO:0000725)2.47157828
106tRNA methylation (GO:0030488)2.46667128
107eosinophil migration (GO:0072677)2.44936118
108neural tube formation (GO:0001841)2.44136665
109phagosome maturation (GO:0090382)2.43922653
110positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.43779160
111lymphoid progenitor cell differentiation (GO:0002320)2.43002946
112preassembly of GPI anchor in ER membrane (GO:0016254)2.42870409
113mitochondrial RNA metabolic process (GO:0000959)2.42596477
114cullin deneddylation (GO:0010388)2.42364603
115protein targeting to mitochondrion (GO:0006626)2.41725377
116otic vesicle formation (GO:0030916)2.41565546
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41481127
118long-chain fatty acid biosynthetic process (GO:0042759)2.39724768
119motile cilium assembly (GO:0044458)2.39667599
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.39470402
121cellular response to interferon-beta (GO:0035458)2.39409646
122indolalkylamine metabolic process (GO:0006586)2.38945406
123dendritic cell chemotaxis (GO:0002407)2.36495087
124response to interferon-beta (GO:0035456)2.36033991
125positive regulation of developmental pigmentation (GO:0048087)2.32928704
126negative regulation of heart rate (GO:0010459)2.31946407
127regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.30330951
128startle response (GO:0001964)2.30086538
129embryonic foregut morphogenesis (GO:0048617)2.28655666
130C-terminal protein lipidation (GO:0006501)2.28617948
131fibroblast migration (GO:0010761)2.28578642
132protein localization to cilium (GO:0061512)2.28421137
133regulation of platelet aggregation (GO:0090330)2.28279609
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.27932738
135adenosine metabolic process (GO:0046085)2.27683341
136limb development (GO:0060173)2.27454577
137appendage development (GO:0048736)2.27454577
138auditory receptor cell stereocilium organization (GO:0060088)2.27278669
139viral protein processing (GO:0019082)2.27035808
140regulation of gene silencing by RNA (GO:0060966)2.26842293
141regulation of posttranscriptional gene silencing (GO:0060147)2.26842293
142regulation of gene silencing by miRNA (GO:0060964)2.26842293
143regulation of DNA endoreduplication (GO:0032875)2.26694798
144serotonin receptor signaling pathway (GO:0007210)2.26232238
145glucosamine-containing compound catabolic process (GO:1901072)2.26197817
146water-soluble vitamin biosynthetic process (GO:0042364)2.25927146
147termination of RNA polymerase I transcription (GO:0006363)2.25430627
148negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.25303914
149regulation of timing of cell differentiation (GO:0048505)2.24550556
150inner ear receptor stereocilium organization (GO:0060122)2.23370264
151oxidative demethylation (GO:0070989)2.22913624
152establishment of protein localization to mitochondrion (GO:0072655)2.21210951
153retinal cone cell development (GO:0046549)2.20854655
154glycolipid biosynthetic process (GO:0009247)2.20769739
155negative regulation of response to food (GO:0032096)2.19152437
156negative regulation of appetite (GO:0032099)2.19152437
157methionine biosynthetic process (GO:0009086)2.18616298
158DNA ligation (GO:0006266)2.18148379
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.17065392
160left/right axis specification (GO:0070986)2.16721598
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.15419429
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.15419429
163opioid receptor signaling pathway (GO:0038003)2.14925924
164DNA integration (GO:0015074)2.14754814
165RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.14428368
166aerobic respiration (GO:0009060)2.13940681
167C-terminal protein amino acid modification (GO:0018410)2.13808041
168regulation of pigment cell differentiation (GO:0050932)2.13289928
169negative regulation of homotypic cell-cell adhesion (GO:0034111)2.13213346
170protein deneddylation (GO:0000338)2.13169325
171regulation of acyl-CoA biosynthetic process (GO:0050812)2.13153067
172tryptophan metabolic process (GO:0006568)2.12953441
173GTP biosynthetic process (GO:0006183)2.12942047
174behavioral response to nicotine (GO:0035095)2.12876562
175ribonucleoprotein complex disassembly (GO:0032988)2.12125215
176histone H2A acetylation (GO:0043968)2.11337347
177regulation of skeletal muscle contraction (GO:0014819)2.10915492
178retinal rod cell development (GO:0046548)2.10451466
179negative regulation of transcription regulatory region DNA binding (GO:2000678)2.09513045
180reflex (GO:0060004)2.08696705
181cellular response to sterol (GO:0036315)2.08486833
182acrosome assembly (GO:0001675)2.06862676
183regulation of hippo signaling (GO:0035330)2.06596263
184regulation of cardioblast differentiation (GO:0051890)2.05941631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.33406530
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10644207
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.07938762
4TAF15_26573619_Chip-Seq_HEK293_Human2.83959493
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.62978648
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60331167
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57511057
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55910660
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50863043
10ZNF274_21170338_ChIP-Seq_K562_Hela2.41116508
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27686590
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23358552
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22235817
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16558915
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12078793
16FUS_26573619_Chip-Seq_HEK293_Human2.08598845
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.01484421
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.00831772
19EZH2_22144423_ChIP-Seq_EOC_Human1.99451056
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98456398
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98198656
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96839964
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95031251
24P300_19829295_ChIP-Seq_ESCs_Human1.91155156
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87739255
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85677867
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.85250892
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.80271682
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78579691
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.73632122
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73219099
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.71225252
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70692609
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70333495
35STAT3_23295773_ChIP-Seq_U87_Human1.65461296
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65457366
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64568943
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.62942396
39EWS_26573619_Chip-Seq_HEK293_Human1.60904188
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60227462
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60083645
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58678679
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.58361843
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56998740
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56130662
46CBP_20019798_ChIP-Seq_JUKART_Human1.56094557
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56094557
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53965340
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.52687918
50ER_23166858_ChIP-Seq_MCF-7_Human1.52317416
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52312735
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51808815
53P53_22387025_ChIP-Seq_ESCs_Mouse1.51799502
54VDR_22108803_ChIP-Seq_LS180_Human1.51300698
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50060325
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.49901270
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49402483
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.47426013
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45913010
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45743308
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44601250
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.44312878
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44212415
64IGF1R_20145208_ChIP-Seq_DFB_Human1.44071965
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43905921
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42388471
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42191937
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41482743
69IRF1_19129219_ChIP-ChIP_H3396_Human1.40323277
70RNF2_27304074_Chip-Seq_NSC_Mouse1.40040048
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.39288443
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38706827
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38358107
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37609349
75TCF4_23295773_ChIP-Seq_U87_Human1.36364800
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35439057
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34383280
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34288172
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34252948
80SMAD4_21799915_ChIP-Seq_A2780_Human1.33869895
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33636340
82MYC_18940864_ChIP-ChIP_HL60_Human1.33331025
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31739471
84P300_18555785_Chip-Seq_ESCs_Mouse1.30392243
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.30250061
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.29872066
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29726999
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29684917
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29156115
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29156115
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28138808
92* VDR_23849224_ChIP-Seq_CD4+_Human1.27750699
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27257504
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.26354865
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26214331
96ELK1_19687146_ChIP-ChIP_HELA_Human1.23271565
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23057665
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22897199
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22788431
100TCF4_22108803_ChIP-Seq_LS180_Human1.22248217
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.22240774
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20913303
103AR_25329375_ChIP-Seq_VCAP_Human1.20394217
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20113865
105* PIAS1_25552417_ChIP-Seq_VCAP_Human1.19367915
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.19248534
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.18963264
108ZFX_18555785_Chip-Seq_ESCs_Mouse1.18866927
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16372902
110BCAT_22108803_ChIP-Seq_LS180_Human1.15701684
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.15156532
112* NANOG_19829295_ChIP-Seq_ESCs_Human1.14535127
113* SOX2_19829295_ChIP-Seq_ESCs_Human1.14535127
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.14482710
115IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13752512
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.13720789
117CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11818494
118TP53_22573176_ChIP-Seq_HFKS_Human1.11524320
119* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10921758
120PU1_27457419_Chip-Seq_LIVER_Mouse1.10060587
121AR_21572438_ChIP-Seq_LNCaP_Human1.09661008
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09522823
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09002239
124* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08692138
125* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07303112
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.07165401
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.06845947
128JUN_21703547_ChIP-Seq_K562_Human1.06842206
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06515974
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05191963
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05070711
132* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04021245
133RUNX2_22187159_ChIP-Seq_PCA_Human1.03659019
134* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02980363
135RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02471030
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02021988
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02021988
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.01863757
139ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01759814
140FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00057890
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98314512
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98314512
143CDX2_22108803_ChIP-Seq_LS180_Human0.96290499
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94473392
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93639943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.54589963
2MP0006292_abnormal_olfactory_placode3.08097814
3MP0001188_hyperpigmentation2.87933057
4MP0002736_abnormal_nociception_after2.73109202
5MP0005645_abnormal_hypothalamus_physiol2.69892580
6MP0005171_absent_coat_pigmentation2.67804209
7MP0001986_abnormal_taste_sensitivity2.54206232
8MP0009379_abnormal_foot_pigmentation2.40667271
9MP0005646_abnormal_pituitary_gland2.36604323
10MP0006276_abnormal_autonomic_nervous2.29037000
11MP0000566_synostosis2.27590528
12MP0001968_abnormal_touch/_nociception2.27445498
13MP0003941_abnormal_skin_development2.26958694
14MP0010386_abnormal_urinary_bladder2.18299784
15MP0001529_abnormal_vocalization2.14743741
16MP0004142_abnormal_muscle_tone2.01390906
17MP0003890_abnormal_embryonic-extraembry1.97976805
18MP0005379_endocrine/exocrine_gland_phen1.95708015
19MP0003567_abnormal_fetal_cardiomyocyte1.93463456
20MP0002638_abnormal_pupillary_reflex1.91351752
21MP0001905_abnormal_dopamine_level1.91141135
22MP0002735_abnormal_chemical_nociception1.91038207
23MP0002876_abnormal_thyroid_physiology1.87089879
24MP0005409_darkened_coat_color1.82811647
25MP0002132_abnormal_respiratory_system1.76549296
26MP0009745_abnormal_behavioral_response1.74913610
27MP0000015_abnormal_ear_pigmentation1.69719783
28MP0002938_white_spotting1.69554313
29MP0002148_abnormal_hypersensitivity_rea1.69492526
30MP0003937_abnormal_limbs/digits/tail_de1.68233006
31MP0000372_irregular_coat_pigmentation1.66932592
32MP0009697_abnormal_copulation1.60358729
33MP0004145_abnormal_muscle_electrophysio1.58666111
34MP0005174_abnormal_tail_pigmentation1.57086371
35MP0003136_yellow_coat_color1.56947689
36MP0002163_abnormal_gland_morphology1.53652715
37MP0002234_abnormal_pharynx_morphology1.50986086
38MP0001293_anophthalmia1.49895400
39MP0003950_abnormal_plasma_membrane1.49642393
40MP0001486_abnormal_startle_reflex1.49012684
41MP0002160_abnormal_reproductive_system1.47086647
42MP0005423_abnormal_somatic_nervous1.46396866
43MP0008260_abnormal_autophagy1.43801753
44MP0008877_abnormal_DNA_methylation1.42479406
45MP0002272_abnormal_nervous_system1.40725884
46MP0006072_abnormal_retinal_apoptosis1.39848681
47MP0000749_muscle_degeneration1.36612298
48MP0008789_abnormal_olfactory_epithelium1.36111212
49MP0002067_abnormal_sensory_capabilities1.35653274
50MP0002064_seizures1.35553394
51MP0002572_abnormal_emotion/affect_behav1.34685574
52MP0004742_abnormal_vestibular_system1.32374610
53MP0001984_abnormal_olfaction1.31431654
54MP0002733_abnormal_thermal_nociception1.30727579
55MP0001299_abnormal_eye_distance/1.30229105
56MP0005671_abnormal_response_to1.29871013
57MP0010094_abnormal_chromosome_stability1.29636131
58MP0001661_extended_life_span1.28598469
59MP0009046_muscle_twitch1.28387864
60MP0008995_early_reproductive_senescence1.26620338
61MP0002277_abnormal_respiratory_mucosa1.26477059
62MP0003718_maternal_effect1.25795339
63MP0002233_abnormal_nose_morphology1.24142817
64MP0003195_calcinosis1.23797266
65MP0001970_abnormal_pain_threshold1.22535475
66MP0003724_increased_susceptibility_to1.22223398
67MP0002557_abnormal_social/conspecific_i1.21412184
68MP0001501_abnormal_sleep_pattern1.18737368
69MP0003119_abnormal_digestive_system1.18160950
70MP0002653_abnormal_ependyma_morphology1.17984099
71MP0002095_abnormal_skin_pigmentation1.16136036
72MP0003635_abnormal_synaptic_transmissio1.14573447
73MP0005187_abnormal_penis_morphology1.14544559
74MP0000049_abnormal_middle_ear1.13668914
75MP0000026_abnormal_inner_ear1.10613590
76MP0002102_abnormal_ear_morphology1.09315689
77MP0009785_altered_susceptibility_to1.08743727
78MP0001502_abnormal_circadian_rhythm1.07812034
79MP0002210_abnormal_sex_determination1.07041296
80MP0003122_maternal_imprinting1.06962189
81MP0010030_abnormal_orbit_morphology1.06487943
82MP0001929_abnormal_gametogenesis1.05863764
83MP0000778_abnormal_nervous_system1.05012854
84MP0003137_abnormal_impulse_conducting1.04365207
85MP0005367_renal/urinary_system_phenotyp1.03922989
86MP0000516_abnormal_urinary_system1.03922989
87MP0001963_abnormal_hearing_physiology1.03241445
88MP0002127_abnormal_cardiovascular_syste1.02495941
89MP0000569_abnormal_digit_pigmentation1.01330290
90MP0003942_abnormal_urinary_system1.01279816
91MP0009384_cardiac_valve_regurgitation1.00933280
92MP0005391_vision/eye_phenotype1.00660450
93MP0002184_abnormal_innervation1.00144372
94MP0001835_abnormal_antigen_presentation0.99258380
95MP0002751_abnormal_autonomic_nervous0.99228941
96MP0002822_catalepsy0.98759571
97MP0003698_abnormal_male_reproductive0.97075642
98MP0009250_abnormal_appendicular_skeleto0.96869543
99MP0008007_abnormal_cellular_replicative0.96277153
100MP0001145_abnormal_male_reproductive0.95503372
101MP0004924_abnormal_behavior0.95441911
102MP0005386_behavior/neurological_phenoty0.95441911
103MP0000653_abnormal_sex_gland0.93696023
104MP0002063_abnormal_learning/memory/cond0.92138289
105MP0001764_abnormal_homeostasis0.92045420
106MP0002734_abnormal_mechanical_nocicepti0.91699930
107MP0000631_abnormal_neuroendocrine_gland0.91565951
108MP0000681_abnormal_thyroid_gland0.91099189
109MP0002928_abnormal_bile_duct0.89897808
110MP0003077_abnormal_cell_cycle0.89364910
111MP0004084_abnormal_cardiac_muscle0.89330191
112MP0000538_abnormal_urinary_bladder0.89018259
113MP0001286_abnormal_eye_development0.88980213
114MP0002282_abnormal_trachea_morphology0.88713293
115MP0005389_reproductive_system_phenotype0.88530241
116MP0005499_abnormal_olfactory_system0.88366104
117MP0005394_taste/olfaction_phenotype0.88366104
118MP0008932_abnormal_embryonic_tissue0.87124908
119MP0009780_abnormal_chondrocyte_physiolo0.87036977
120MP0006035_abnormal_mitochondrial_morpho0.86315025
121MP0002697_abnormal_eye_size0.86153576
122MP0003183_abnormal_peptide_metabolism0.85173985
123MP0003755_abnormal_palate_morphology0.84981677
124MP0003221_abnormal_cardiomyocyte_apopto0.84770680
125MP0004134_abnormal_chest_morphology0.84450156
126MP0000678_abnormal_parathyroid_gland0.84415524
127MP0002090_abnormal_vision0.83914836
128MP0000427_abnormal_hair_cycle0.83904357
129MP0006054_spinal_hemorrhage0.83868894
130MP0005195_abnormal_posterior_eye0.83820328
131* MP0004957_abnormal_blastocyst_morpholog0.83802648
132MP0004133_heterotaxia0.83274521
133MP0001542_abnormal_bone_strength0.82986900
134MP0005167_abnormal_blood-brain_barrier0.82533446
135MP0004085_abnormal_heartbeat0.81733690
136MP0002837_dystrophic_cardiac_calcinosis0.81440372
137MP0003786_premature_aging0.81054292
138MP0003121_genomic_imprinting0.81030951
139* MP0002084_abnormal_developmental_patter0.79410729
140MP0003693_abnormal_embryo_hatching0.79082795
141MP0001440_abnormal_grooming_behavior0.78837036
142MP0003787_abnormal_imprinting0.78742781
143MP0002269_muscular_atrophy0.78508169
144MP0004381_abnormal_hair_follicle0.78331419
145MP0004043_abnormal_pH_regulation0.78128301
146MP0002752_abnormal_somatic_nervous0.77980681
147MP0008057_abnormal_DNA_replication0.77979444
148MP0010368_abnormal_lymphatic_system0.77546489
149MP0005000_abnormal_immune_tolerance0.76098675
150MP0004147_increased_porphyrin_level0.76056902
151MP0008058_abnormal_DNA_repair0.75159420
152MP0001186_pigmentation_phenotype0.74753613
153MP0005551_abnormal_eye_electrophysiolog0.73926784
154MP0005075_abnormal_melanosome_morpholog0.73035019
155MP0001485_abnormal_pinna_reflex0.71316299
156MP0002419_abnormal_innate_immunity0.70568252
157MP0005257_abnormal_intraocular_pressure0.70099325
158MP0001790_abnormal_immune_system0.68417602
159MP0005387_immune_system_phenotype0.68417602
160MP0004484_altered_response_of0.66907863
161MP0003646_muscle_fatigue0.63963393
162MP0005503_abnormal_tendon_morphology0.63727254
163MP0005253_abnormal_eye_physiology0.63033789
164MP0002177_abnormal_outer_ear0.61986478
165MP0002249_abnormal_larynx_morphology0.61419766
166MP0004215_abnormal_myocardial_fiber0.60451783

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.24679034
2Mitochondrial inheritance (HP:0001427)4.69711905
3Abnormal mitochondria in muscle tissue (HP:0008316)4.52497623
4Progressive macrocephaly (HP:0004481)4.32348707
5Hypothermia (HP:0002045)4.08994788
6Increased CSF lactate (HP:0002490)3.97014873
7Increased hepatocellular lipid droplets (HP:0006565)3.90548686
8Acute encephalopathy (HP:0006846)3.88235053
9Renal Fanconi syndrome (HP:0001994)3.69429569
10Hepatocellular necrosis (HP:0001404)3.51572368
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48290237
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.38738848
133-Methylglutaconic aciduria (HP:0003535)3.24202088
14Nephronophthisis (HP:0000090)3.15882958
15Lipid accumulation in hepatocytes (HP:0006561)3.15635773
16Gonadal dysgenesis (HP:0000133)3.14621684
17Cerebellar dysplasia (HP:0007033)3.11697981
18Chronic hepatic failure (HP:0100626)3.02474622
19Hepatic necrosis (HP:0002605)2.98710195
20Abnormal hair whorl (HP:0010721)2.94831736
21Optic disc pallor (HP:0000543)2.93778556
22Focal motor seizures (HP:0011153)2.93589958
23Occipital encephalocele (HP:0002085)2.75861355
24True hermaphroditism (HP:0010459)2.75399461
25Exertional dyspnea (HP:0002875)2.74874532
26Abnormality of the renal medulla (HP:0100957)2.72521143
27Patchy hypopigmentation of hair (HP:0011365)2.68640179
28Exercise intolerance (HP:0003546)2.68262187
29Abnormality of renal resorption (HP:0011038)2.67521199
30Volvulus (HP:0002580)2.67388970
31Colon cancer (HP:0003003)2.62838023
32Poor coordination (HP:0002370)2.59213376
33Type I transferrin isoform profile (HP:0003642)2.57457013
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.54525973
35Tubulointerstitial nephritis (HP:0001970)2.54115990
36Hyperglycinemia (HP:0002154)2.53573404
37Increased serum lactate (HP:0002151)2.52175876
38Lactic acidosis (HP:0003128)2.49723233
39Pancreatic fibrosis (HP:0100732)2.49179034
40Abnormal ciliary motility (HP:0012262)2.48598205
41White forelock (HP:0002211)2.48519926
42Intestinal atresia (HP:0011100)2.45281514
43Cystic liver disease (HP:0006706)2.40094490
44Medial flaring of the eyebrow (HP:0010747)2.38967213
45Febrile seizures (HP:0002373)2.38717277
46Epileptic encephalopathy (HP:0200134)2.35332607
47Submucous cleft hard palate (HP:0000176)2.33613417
48Parakeratosis (HP:0001036)2.32858509
49Microvesicular hepatic steatosis (HP:0001414)2.32018978
50Congenital sensorineural hearing impairment (HP:0008527)2.30345931
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27193678
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27193678
53Respiratory failure (HP:0002878)2.26805501
54Anencephaly (HP:0002323)2.26327024
55Cerebral edema (HP:0002181)2.26020385
56Respiratory difficulties (HP:0002880)2.25427155
57Abnormal respiratory motile cilium physiology (HP:0012261)2.23810247
58Postaxial foot polydactyly (HP:0001830)2.23395151
59Bifid tongue (HP:0010297)2.23360175
60Increased intramyocellular lipid droplets (HP:0012240)2.20477327
61Gaze-evoked nystagmus (HP:0000640)2.19630658
62Rimmed vacuoles (HP:0003805)2.18553337
63Hyperglycinuria (HP:0003108)2.15154536
64Bile duct proliferation (HP:0001408)2.14333668
65Abnormal biliary tract physiology (HP:0012439)2.14333668
66Abnormality of incisor morphology (HP:0011063)2.14006110
67Congenital hepatic fibrosis (HP:0002612)2.11614049
68Sclerocornea (HP:0000647)2.11149449
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10703102
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.10703102
71Conical tooth (HP:0000698)2.10523770
72Central scotoma (HP:0000603)2.07870276
73Abnormal lung lobation (HP:0002101)2.07519480
74Type 2 muscle fiber atrophy (HP:0003554)2.07209121
75Nephrogenic diabetes insipidus (HP:0009806)2.05986804
76Leukodystrophy (HP:0002415)2.03680759
77Broad foot (HP:0001769)2.01559143
78Abnormality of the ileum (HP:0001549)1.99191147
79Postaxial hand polydactyly (HP:0001162)1.97001358
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96330103
81Abnormal sex determination (HP:0012244)1.95822239
82Sex reversal (HP:0012245)1.95822239
83Increased IgM level (HP:0003496)1.95750821
84Pancreatic cysts (HP:0001737)1.95505905
85Exercise-induced muscle cramps (HP:0003710)1.93521413
86Preaxial foot polydactyly (HP:0001841)1.93105285
87Renal tubular dysfunction (HP:0000124)1.92933613
88Abnormality of glycine metabolism (HP:0010895)1.90823402
89Abnormality of serine family amino acid metabolism (HP:0010894)1.90823402
90Congenital primary aphakia (HP:0007707)1.90724641
91Rhinitis (HP:0012384)1.90343749
92X-linked dominant inheritance (HP:0001423)1.86516581
93Abnormality of the axillary hair (HP:0100134)1.85760990
94Abnormality of secondary sexual hair (HP:0009888)1.85760990
95Thyroid-stimulating hormone excess (HP:0002925)1.84804800
96Abnormality of the renal cortex (HP:0011035)1.84059238
97Retinal dysplasia (HP:0007973)1.83594260
98Osteomalacia (HP:0002749)1.82989971
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.82058228
100Gait imbalance (HP:0002141)1.82005084
101Supernumerary spleens (HP:0009799)1.81169183
102Oculomotor apraxia (HP:0000657)1.80930408
103Optic nerve hypoplasia (HP:0000609)1.80799385
104Decreased circulating renin level (HP:0003351)1.80400858
105Aplasia/Hypoplasia of the tibia (HP:0005772)1.79973402
106Progressive external ophthalmoplegia (HP:0000590)1.79533283
107Chromsome breakage (HP:0040012)1.79058755
108Sloping forehead (HP:0000340)1.78773053
109Aplasia cutis congenita (HP:0001057)1.78107891
110Dandy-Walker malformation (HP:0001305)1.77665801
111Aplasia/Hypoplasia of the lens (HP:0008063)1.77322409
112Nonprogressive disorder (HP:0003680)1.76315190
113Abnormality of dental color (HP:0011073)1.76191914
114Astigmatism (HP:0000483)1.75974135
115Bony spicule pigmentary retinopathy (HP:0007737)1.75455091
116Reticulocytopenia (HP:0001896)1.74954078
117Nasolacrimal duct obstruction (HP:0000579)1.74819118
118Aganglionic megacolon (HP:0002251)1.74113532
119Scotoma (HP:0000575)1.74071683
120Abnormality of the corticospinal tract (HP:0002492)1.74045815
121Testicular neoplasm (HP:0010788)1.74035218
122Abnormality of the labia minora (HP:0012880)1.74003027
123Tubular atrophy (HP:0000092)1.72494147
124Proximal tubulopathy (HP:0000114)1.72019524
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71909751
126Abnormal protein N-linked glycosylation (HP:0012347)1.71909751
127Abnormal protein glycosylation (HP:0012346)1.71909751
128Abnormal glycosylation (HP:0012345)1.71909751
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70648545
130Abnormality of chromosome stability (HP:0003220)1.69328037
131Hyperphosphaturia (HP:0003109)1.69274550
132Abnormality of midbrain morphology (HP:0002418)1.69125653
133Molar tooth sign on MRI (HP:0002419)1.69125653
134Prominent nasal bridge (HP:0000426)1.68560230
135Genital tract atresia (HP:0001827)1.68367727
136CNS demyelination (HP:0007305)1.67612440
137Decreased testicular size (HP:0008734)1.67474512
138Abnormality of the lacrimal duct (HP:0011481)1.66881998
139Embryonal renal neoplasm (HP:0011794)1.66835470
140Meckel diverticulum (HP:0002245)1.66313643
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66244748
142Reduced antithrombin III activity (HP:0001976)1.65574850
143Retrobulbar optic neuritis (HP:0100654)1.65517912
144Optic neuritis (HP:0100653)1.65517912
145Abnormal pupillary function (HP:0007686)1.65119693
146Abnormality of urine glucose concentration (HP:0011016)1.64751380
147Glycosuria (HP:0003076)1.64751380
148Absent/shortened dynein arms (HP:0200106)1.64201444
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.64201444
150Aplasia/hypoplasia of the uterus (HP:0008684)1.63555177
151Vaginal atresia (HP:0000148)1.62923828
152Hyperventilation (HP:0002883)1.61703863
153Preaxial hand polydactyly (HP:0001177)1.61659656
154Male pseudohermaphroditism (HP:0000037)1.59634237
155Attenuation of retinal blood vessels (HP:0007843)1.59354591
156Dry hair (HP:0011359)1.58293940
157Abnormality of the renal collecting system (HP:0004742)1.58231187
158Renal cortical cysts (HP:0000803)1.57989833
159Median cleft lip (HP:0000161)1.57259029
160Esotropia (HP:0000565)1.56551609
161Type II lissencephaly (HP:0007260)1.55382403
162Abnormality of the nasolacrimal system (HP:0000614)1.54684335
163Abnormal respiratory motile cilium morphology (HP:0005938)1.54285370
164Abnormal respiratory epithelium morphology (HP:0012253)1.54285370
165Short tibia (HP:0005736)1.53876134
166Abnormality of the parietal bone (HP:0002696)1.52554781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.15554186
2CASK4.45363517
3MAP3K123.76608005
4TIE13.65516292
5STK163.38825639
6TRIM283.24948692
7TNIK2.56387300
8MUSK2.48995958
9ADRBK22.30049529
10MAP2K72.28547366
11SIK32.25135205
12TXK2.05177967
13IRAK42.04184770
14IRAK32.01451426
15NME12.00307373
16BMPR1B1.99947078
17GRK71.90152577
18ZAK1.88390257
19BMPR21.87002005
20LATS11.67109293
21BRSK21.66417101
22CSNK1G11.60739842
23MYLK1.56835889
24YES11.55821908
25NEK61.53393622
26AKT31.52980438
27MST41.49338085
28PIK3CG1.48248179
29RIPK41.46014222
30MAPK131.45945473
31NTRK31.45447895
32VRK11.43792305
33MAP4K21.36836645
34TEC1.33529795
35PNCK1.31311337
36MAP3K141.29998394
37WEE11.28769877
38TGFBR11.27901844
39MKNK21.25356593
40MAPKAPK51.20755549
41PLK31.19788608
42FER1.17922383
43MKNK11.17826321
44NME21.17678498
45PINK11.15894011
46BUB11.14945804
47CDK81.11197308
48EIF2AK21.10897749
49CSNK1A1L1.10684649
50CSNK1G31.09878714
51NLK1.08952390
52STK241.07573285
53CSNK1G21.06091797
54TTK1.04183864
55SRPK11.04073706
56PBK1.03076280
57VRK21.02382077
58KIT1.00801801
59CDK31.00544137
60PLK20.97853968
61IRAK10.96660789
62PIM20.96181933
63PRPF4B0.94859575
64INSRR0.91752093
65GRK50.91118575
66OBSCN0.89071025
67PRKCE0.87894692
68CDC70.84467679
69STK30.83984596
70PLK10.83081108
71SGK20.81503517
72PDK20.81124317
73TAF10.79014424
74PAK30.78879031
75CCNB10.78142157
76OXSR10.77414022
77EIF2AK10.73620657
78IRAK20.73350601
79IKBKB0.70781978
80ADRBK10.68653233
81TSSK60.67661634
82MAP3K40.67586619
83TAOK20.67139412
84TNK20.65949053
85CAMK2A0.65808787
86EIF2AK30.63548604
87FGFR20.61760854
88CHEK20.61432879
89FES0.60750353
90STK38L0.59383225
91ATM0.58576670
92ERBB30.57764142
93ATR0.57750934
94BRSK10.57712576
95NUAK10.57241466
96DYRK1A0.55164683
97DAPK10.53198870
98SYK0.52903114
99STK390.51808743
100LYN0.51373009
101TLK10.50498274
102DYRK30.50339234
103SGK2230.49156941
104SGK4940.49156941
105BRAF0.49129372
106CAMK2B0.48699298
107CAMK2D0.47667182
108IKBKE0.47627643
109FGFR10.46922661
110NEK10.45546366
111MAPK70.44741799
112WNK30.44644661
113PRKACA0.44387771
114MAP2K40.44021890
115BCR0.42847655
116MAPK150.40266268
117GRK10.38718708
118PLK40.38309999
119EPHB20.37057346
120PTK2B0.36548538
121AURKB0.35073621
122RPS6KA50.34947374
123CDK190.34709907
124PRKACB0.34597079
125PIK3CA0.33971113
126BRD40.33134016
127CHEK10.32723228
128PRKG10.32174951
129PRKCD0.32030610
130PRKCG0.31761456
131BTK0.31375800
132PRKCQ0.31155947
133PHKG10.31116747
134PHKG20.31116747
135CSNK1D0.31078360
136DYRK20.30894321
137EPHA40.30074626
138MAP3K50.29862135
139LCK0.29427013
140CSNK2A10.29277984
141PRKAA10.29177558
142CSNK1A10.29151118
143MAP2K60.28841310
144PRKAA20.28818348
145PRKDC0.28616047
146PRKCA0.28262284
147ACVR1B0.25809997

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.60996259
2Parkinsons disease_Homo sapiens_hsa050123.64591674
3Protein export_Homo sapiens_hsa030603.03220017
4Propanoate metabolism_Homo sapiens_hsa006402.94394213
5Alzheimers disease_Homo sapiens_hsa050102.88730571
6RNA polymerase_Homo sapiens_hsa030202.69220862
7Huntingtons disease_Homo sapiens_hsa050162.64794530
8Ribosome_Homo sapiens_hsa030102.38954664
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35837736
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29662257
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14223953
12Butanoate metabolism_Homo sapiens_hsa006502.08595004
13Collecting duct acid secretion_Homo sapiens_hsa049662.07505792
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04993390
15Proteasome_Homo sapiens_hsa030502.03505614
16Nicotine addiction_Homo sapiens_hsa050331.97653082
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95372512
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71437923
19Rheumatoid arthritis_Homo sapiens_hsa053231.71321302
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69933687
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68286159
22Non-homologous end-joining_Homo sapiens_hsa034501.63231235
23Selenocompound metabolism_Homo sapiens_hsa004501.62426256
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.59105302
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56658523
26Cardiac muscle contraction_Homo sapiens_hsa042601.55289411
27Graft-versus-host disease_Homo sapiens_hsa053321.53511422
28Basal transcription factors_Homo sapiens_hsa030221.46142954
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41779726
30Serotonergic synapse_Homo sapiens_hsa047261.41734801
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39381544
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.36239572
33Tryptophan metabolism_Homo sapiens_hsa003801.30367049
34Homologous recombination_Homo sapiens_hsa034401.27418419
35RNA degradation_Homo sapiens_hsa030181.26088651
36Vibrio cholerae infection_Homo sapiens_hsa051101.24296003
37Arachidonic acid metabolism_Homo sapiens_hsa005901.22045857
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21777781
39Allograft rejection_Homo sapiens_hsa053301.21681646
40Taste transduction_Homo sapiens_hsa047421.20617720
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18642753
42RNA transport_Homo sapiens_hsa030131.17457311
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16967651
44Pyrimidine metabolism_Homo sapiens_hsa002401.16540169
45Vitamin B6 metabolism_Homo sapiens_hsa007501.15589069
46Pyruvate metabolism_Homo sapiens_hsa006201.15296933
47beta-Alanine metabolism_Homo sapiens_hsa004101.14201637
48Synaptic vesicle cycle_Homo sapiens_hsa047211.11824582
49Base excision repair_Homo sapiens_hsa034101.11677549
50Peroxisome_Homo sapiens_hsa041461.11599559
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09748544
52One carbon pool by folate_Homo sapiens_hsa006701.09691531
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.09637438
54ABC transporters_Homo sapiens_hsa020101.09388101
55Type I diabetes mellitus_Homo sapiens_hsa049401.06504023
56Sphingolipid metabolism_Homo sapiens_hsa006001.05477727
57Morphine addiction_Homo sapiens_hsa050321.05182462
58Fatty acid degradation_Homo sapiens_hsa000711.03950743
59DNA replication_Homo sapiens_hsa030301.02139106
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01536513
61Phototransduction_Homo sapiens_hsa047441.00932084
62Fanconi anemia pathway_Homo sapiens_hsa034600.97519803
63Autoimmune thyroid disease_Homo sapiens_hsa053200.96244636
64Purine metabolism_Homo sapiens_hsa002300.95215274
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94137200
66Cell cycle_Homo sapiens_hsa041100.93137779
67Fatty acid metabolism_Homo sapiens_hsa012120.91697482
68Phagosome_Homo sapiens_hsa041450.90709965
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90560363
70Steroid biosynthesis_Homo sapiens_hsa001000.90386497
71Hedgehog signaling pathway_Homo sapiens_hsa043400.89214329
72Chemical carcinogenesis_Homo sapiens_hsa052040.88819813
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.87775751
74Glutathione metabolism_Homo sapiens_hsa004800.87220799
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86365894
76Arginine and proline metabolism_Homo sapiens_hsa003300.86340571
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86339356
78Hematopoietic cell lineage_Homo sapiens_hsa046400.85779548
79Regulation of autophagy_Homo sapiens_hsa041400.85718616
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83971739
81Nucleotide excision repair_Homo sapiens_hsa034200.83885637
82Retinol metabolism_Homo sapiens_hsa008300.81850750
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81054237
84Lysine degradation_Homo sapiens_hsa003100.80281287
85African trypanosomiasis_Homo sapiens_hsa051430.79826951
86N-Glycan biosynthesis_Homo sapiens_hsa005100.79191582
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78895371
88Asthma_Homo sapiens_hsa053100.78543027
89Nitrogen metabolism_Homo sapiens_hsa009100.78338503
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77637053
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76089585
92Circadian entrainment_Homo sapiens_hsa047130.75468823
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74861018
94Primary immunodeficiency_Homo sapiens_hsa053400.74822380
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73615884
96Calcium signaling pathway_Homo sapiens_hsa040200.73608994
97Basal cell carcinoma_Homo sapiens_hsa052170.72297758
98mRNA surveillance pathway_Homo sapiens_hsa030150.71941143
99Caffeine metabolism_Homo sapiens_hsa002320.70760394
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69971489
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.68788805
102GABAergic synapse_Homo sapiens_hsa047270.68772353
103TGF-beta signaling pathway_Homo sapiens_hsa043500.68732592
104Glutamatergic synapse_Homo sapiens_hsa047240.68567618
105Amphetamine addiction_Homo sapiens_hsa050310.66564961
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.65853698
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64719104
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64494762
109Oocyte meiosis_Homo sapiens_hsa041140.63468422
110Hippo signaling pathway_Homo sapiens_hsa043900.62982170
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62295433
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62215804
113Carbon metabolism_Homo sapiens_hsa012000.61949544
114Insulin secretion_Homo sapiens_hsa049110.60277142
115Sulfur relay system_Homo sapiens_hsa041220.59738241
116Ether lipid metabolism_Homo sapiens_hsa005650.56271297
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55691433
118Olfactory transduction_Homo sapiens_hsa047400.55625287
119Long-term depression_Homo sapiens_hsa047300.55200770
120Folate biosynthesis_Homo sapiens_hsa007900.54357372
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53605666
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53348801
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52468758
124Spliceosome_Homo sapiens_hsa030400.52398829
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51489271
126Mismatch repair_Homo sapiens_hsa034300.50473658
127Metabolic pathways_Homo sapiens_hsa011000.50147024
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49784829
129Tight junction_Homo sapiens_hsa045300.48562447
130Fatty acid elongation_Homo sapiens_hsa000620.47851541
131p53 signaling pathway_Homo sapiens_hsa041150.47645926
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47353043
133Linoleic acid metabolism_Homo sapiens_hsa005910.46358188
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45461533
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45400986
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44852258
137Malaria_Homo sapiens_hsa051440.43636061
138Pertussis_Homo sapiens_hsa051330.41102639
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40804379
140Measles_Homo sapiens_hsa051620.38830190
141Renin secretion_Homo sapiens_hsa049240.38371224
142Other glycan degradation_Homo sapiens_hsa005110.37949451
143Dopaminergic synapse_Homo sapiens_hsa047280.37864952
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37155664
145Legionellosis_Homo sapiens_hsa051340.36219217
146Cocaine addiction_Homo sapiens_hsa050300.35823692
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.35176197
148Cholinergic synapse_Homo sapiens_hsa047250.33567038
149Tuberculosis_Homo sapiens_hsa051520.33383423
150Sulfur metabolism_Homo sapiens_hsa009200.32951924
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30688522
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26498379
153Long-term potentiation_Homo sapiens_hsa047200.26287591
154Leishmaniasis_Homo sapiens_hsa051400.25078696
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25021518
156Circadian rhythm_Homo sapiens_hsa047100.23568334

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