NAA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.69313511
2viral transcription (GO:0019083)6.08221678
3DNA deamination (GO:0045006)5.91022156
4translational termination (GO:0006415)5.90001606
5ribosomal small subunit biogenesis (GO:0042274)5.57722017
6maturation of SSU-rRNA (GO:0030490)5.34039032
7translational elongation (GO:0006414)5.33240969
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.09736106
9DNA strand elongation involved in DNA replication (GO:0006271)5.00415749
10cotranslational protein targeting to membrane (GO:0006613)4.98891598
11protein targeting to ER (GO:0045047)4.96014174
12telomere maintenance via semi-conservative replication (GO:0032201)4.94990094
13translational initiation (GO:0006413)4.81601378
14protein maturation by protein folding (GO:0022417)4.80946825
15ribosomal large subunit biogenesis (GO:0042273)4.76304419
16DNA strand elongation (GO:0022616)4.75785351
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.71790775
18protein localization to endoplasmic reticulum (GO:0070972)4.70352495
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.70260540
20cellular protein complex disassembly (GO:0043624)4.62820297
21regulation of mitochondrial translation (GO:0070129)4.60252703
22viral life cycle (GO:0019058)4.60123800
23formation of translation preinitiation complex (GO:0001731)4.59289585
24DNA replication initiation (GO:0006270)4.45774752
25ribonucleoprotein complex biogenesis (GO:0022613)4.32084559
26DNA unwinding involved in DNA replication (GO:0006268)4.30988086
27telomere maintenance via recombination (GO:0000722)4.24306808
28protein complex disassembly (GO:0043241)4.15284093
29peptidyl-arginine omega-N-methylation (GO:0035247)4.14596611
30nucleobase-containing small molecule interconversion (GO:0015949)4.14213170
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00615479
32guanosine-containing compound biosynthetic process (GO:1901070)3.99454068
33translation (GO:0006412)3.97970959
34nucleobase biosynthetic process (GO:0046112)3.97613816
35protein targeting to mitochondrion (GO:0006626)3.96485755
36chaperone-mediated protein transport (GO:0072321)3.95706911
37mitotic recombination (GO:0006312)3.93188460
38macromolecular complex disassembly (GO:0032984)3.92868663
39ATP synthesis coupled proton transport (GO:0015986)3.90394462
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90394462
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.89868357
42pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.86389352
43GDP-mannose metabolic process (GO:0019673)3.85914426
44proteasome assembly (GO:0043248)3.84999502
45UTP biosynthetic process (GO:0006228)3.83971818
46telomere maintenance via telomere lengthening (GO:0010833)3.83765292
47rRNA processing (GO:0006364)3.78082783
48DNA replication checkpoint (GO:0000076)3.75047614
49ribosome biogenesis (GO:0042254)3.74371885
50pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.72104145
51spliceosomal snRNP assembly (GO:0000387)3.71576106
52nuclear envelope reassembly (GO:0031468)3.70831411
53mitotic nuclear envelope reassembly (GO:0007084)3.70831411
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.70579991
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.70330639
56pseudouridine synthesis (GO:0001522)3.68697639
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.68360763
58purine nucleobase biosynthetic process (GO:0009113)3.68181242
59GTP biosynthetic process (GO:0006183)3.66646633
60establishment of protein localization to mitochondrion (GO:0072655)3.64825474
61rRNA metabolic process (GO:0016072)3.63409580
62establishment of integrated proviral latency (GO:0075713)3.62733257
63proline biosynthetic process (GO:0006561)3.62489463
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.61935213
65CENP-A containing nucleosome assembly (GO:0034080)3.57033944
66histone arginine methylation (GO:0034969)3.54729315
67mRNA catabolic process (GO:0006402)3.51411582
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50995226
69protein localization to mitochondrion (GO:0070585)3.48758703
70CTP metabolic process (GO:0046036)3.48409400
71CTP biosynthetic process (GO:0006241)3.48409400
72cellular component biogenesis (GO:0044085)3.47629445
73folic acid-containing compound biosynthetic process (GO:0009396)3.46820449
74chromatin remodeling at centromere (GO:0031055)3.46144403
75peptidyl-histidine modification (GO:0018202)3.44705499
76respiratory electron transport chain (GO:0022904)3.44565252
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43284819
78UTP metabolic process (GO:0046051)3.42112917
79RNA catabolic process (GO:0006401)3.39900031
80IMP biosynthetic process (GO:0006188)3.39520961
81ribosome assembly (GO:0042255)3.38942560
82peptidyl-arginine methylation (GO:0018216)3.37823577
83peptidyl-arginine N-methylation (GO:0035246)3.37823577
84electron transport chain (GO:0022900)3.33810169
85transcription-coupled nucleotide-excision repair (GO:0006283)3.33451683
86iron-sulfur cluster assembly (GO:0016226)3.32648744
87metallo-sulfur cluster assembly (GO:0031163)3.32648744
88pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.32251633
89protein localization to kinetochore (GO:0034501)3.29317572
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26226660
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25325549
92negative regulation of ligase activity (GO:0051352)3.25325549
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24541896
94transcription elongation from RNA polymerase III promoter (GO:0006385)3.24255538
95termination of RNA polymerase III transcription (GO:0006386)3.24255538
96regulation of translational fidelity (GO:0006450)3.22563042
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21976660
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21803329
992-deoxyribonucleotide biosynthetic process (GO:0009265)3.21109848
100deoxyribose phosphate biosynthetic process (GO:0046385)3.21109848
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20168739
102protein targeting to membrane (GO:0006612)3.19709603
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.19387348
104viral mRNA export from host cell nucleus (GO:0046784)3.18821316
105DNA replication-independent nucleosome assembly (GO:0006336)3.17963768
106DNA replication-independent nucleosome organization (GO:0034724)3.17963768
107DNA replication-dependent nucleosome organization (GO:0034723)3.17300116
108DNA replication-dependent nucleosome assembly (GO:0006335)3.17300116
109rRNA modification (GO:0000154)3.16028814
110IMP metabolic process (GO:0046040)3.13878211
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13666776
112regulation of translational termination (GO:0006449)3.13589241
113spliceosomal complex assembly (GO:0000245)3.12177001
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11281084
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08015106
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04373757
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04373757
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03874682
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00981571
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00792293
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00792293
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00792293
123regulation of mammary gland epithelial cell proliferation (GO:0033599)2.99923021
124positive regulation of ligase activity (GO:0051351)2.98745177
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96321031
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.96321031
127regulation of cellular amino acid metabolic process (GO:0006521)2.96081018
128rRNA transcription (GO:0009303)2.95872696
129regulation of ubiquitin-protein transferase activity (GO:0051438)2.95838313
130L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94997301
131mitotic metaphase plate congression (GO:0007080)2.94935698
132cell cycle G1/S phase transition (GO:0044843)2.92403155
133G1/S transition of mitotic cell cycle (GO:0000082)2.92403155
134signal transduction involved in cell cycle checkpoint (GO:0072395)2.91612204
135negative regulation of RNA splicing (GO:0033119)2.91265527
136protein localization to chromosome, centromeric region (GO:0071459)2.90483346
137ncRNA processing (GO:0034470)2.88528326
138mitotic nuclear envelope disassembly (GO:0007077)2.85564387
1397-methylguanosine mRNA capping (GO:0006370)2.85397747
140pteridine-containing compound biosynthetic process (GO:0042559)2.85375408
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85037267
142kinetochore organization (GO:0051383)2.84498442
143oxidative phosphorylation (GO:0006119)2.82199271
144telomere organization (GO:0032200)2.81828647
145kinetochore assembly (GO:0051382)2.80657165
1467-methylguanosine RNA capping (GO:0009452)2.80335162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87753288
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45009984
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.36317417
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41933540
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.25538428
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.17004489
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16661965
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09605321
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07483147
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03666312
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03428957
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97937015
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90328381
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88604676
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85463570
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78404704
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74958459
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.69375277
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65857929
20XRN2_22483619_ChIP-Seq_HELA_Human2.57243607
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50534322
22VDR_23849224_ChIP-Seq_CD4+_Human2.34870899
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29309155
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19584640
25FOXP3_21729870_ChIP-Seq_TREG_Human2.15037412
26DCP1A_22483619_ChIP-Seq_HELA_Human2.12535767
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12040612
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06876316
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05848110
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02916546
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01486639
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94439835
33GABP_19822575_ChIP-Seq_HepG2_Human1.93004905
34TTF2_22483619_ChIP-Seq_HELA_Human1.91115913
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.85585207
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75496163
37CIITA_25753668_ChIP-Seq_RAJI_Human1.74864351
38MYC_22102868_ChIP-Seq_BL_Human1.73492644
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73057900
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.68611567
41ZNF263_19887448_ChIP-Seq_K562_Human1.65543777
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65235507
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61769275
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61117416
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61051293
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.59653166
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58273209
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58243578
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57959299
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57906710
51AR_21909140_ChIP-Seq_LNCAP_Human1.57044549
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.55249656
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54032726
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53455177
55ELK1_19687146_ChIP-ChIP_HELA_Human1.49573121
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48141945
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46702636
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43893235
59LXR_22292898_ChIP-Seq_THP-1_Human1.43830594
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42272968
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39554377
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36012898
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35911243
64VDR_21846776_ChIP-Seq_THP-1_Human1.33836433
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33391785
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32569223
67KDM5A_27292631_Chip-Seq_BREAST_Human1.30322989
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27289066
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.23458072
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23372016
71* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22845147
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22260245
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21809718
74RACK7_27058665_Chip-Seq_MCF-7_Human1.21677434
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19036686
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17988812
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.16979753
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16714832
79P68_20966046_ChIP-Seq_HELA_Human1.15709045
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15093144
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14593117
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13280046
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13245217
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.11735843
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11045852
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09066307
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08039217
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07294477
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06219189
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05941018
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05440936
92SPI1_23547873_ChIP-Seq_NB4_Human1.05134354
93MYC_18940864_ChIP-ChIP_HL60_Human1.04867261
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04644762
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04216651
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04076659
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03981799
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.03096530
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02612266
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.01829871
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.01247651
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00818215
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99788909
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98732070
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98597139
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97371496
107PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95584005
108BCL6_27268052_Chip-Seq_Bcells_Human0.95384268
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94898390
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94775536
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94369741
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92785857
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92290517
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92226041
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91038425
116TFEB_21752829_ChIP-Seq_HELA_Human0.88601986
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.86904057
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85448039
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84890136
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84027042
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83340352
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80935266
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79158841
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77190079
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.76994847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69015298
2MP0004957_abnormal_blastocyst_morpholog4.42572324
3MP0010094_abnormal_chromosome_stability4.08533258
4MP0003111_abnormal_nucleus_morphology3.97190629
5MP0003077_abnormal_cell_cycle3.76889126
6MP0008057_abnormal_DNA_replication3.33681926
7MP0002396_abnormal_hematopoietic_system3.23875666
8MP0008058_abnormal_DNA_repair3.07824534
9MP0005451_abnormal_body_composition3.04881126
10MP0002877_abnormal_melanocyte_morpholog2.74837380
11MP0008007_abnormal_cellular_replicative2.69780365
12MP0003806_abnormal_nucleotide_metabolis2.69412359
13MP0009379_abnormal_foot_pigmentation2.60578814
14MP0008932_abnormal_embryonic_tissue2.50290136
15MP0003763_abnormal_thymus_physiology2.28794784
16MP0000678_abnormal_parathyroid_gland2.28653808
17MP0000490_abnormal_crypts_of2.14921065
18MP0004233_abnormal_muscle_weight2.05332178
19MP0002249_abnormal_larynx_morphology2.03525022
20MP0001730_embryonic_growth_arrest2.03450220
21MP0009333_abnormal_splenocyte_physiolog2.00064980
22MP0005058_abnormal_lysosome_morphology1.97120254
23MP0003786_premature_aging1.94935269
24MP0005623_abnormal_meninges_morphology1.94019172
25MP0000350_abnormal_cell_proliferation1.90300256
26MP0003123_paternal_imprinting1.88847379
27MP0001661_extended_life_span1.73739979
28MP0005075_abnormal_melanosome_morpholog1.69897852
29MP0003186_abnormal_redox_activity1.62568746
30MP0005397_hematopoietic_system_phenotyp1.62568727
31MP0001545_abnormal_hematopoietic_system1.62568727
32MP0006036_abnormal_mitochondrial_physio1.62322982
33MP0002132_abnormal_respiratory_system1.61420119
34MP0002019_abnormal_tumor_incidence1.60589566
35MP0008260_abnormal_autophagy1.60050824
36MP0002398_abnormal_bone_marrow1.59551321
37MP0004185_abnormal_adipocyte_glucose1.58776740
38MP0002722_abnormal_immune_system1.55369104
39MP0000313_abnormal_cell_death1.55156470
40MP0001853_heart_inflammation1.54473955
41MP0000703_abnormal_thymus_morphology1.53625379
42MP0002234_abnormal_pharynx_morphology1.53305862
43MP0003705_abnormal_hypodermis_morpholog1.49684021
44MP0000537_abnormal_urethra_morphology1.48235698
45MP0000750_abnormal_muscle_regeneration1.48075197
46MP0001346_abnormal_lacrimal_gland1.48004910
47MP0000689_abnormal_spleen_morphology1.47923207
48MP0004808_abnormal_hematopoietic_stem1.44102648
49MP0004858_abnormal_nervous_system1.43222720
50MP0002080_prenatal_lethality1.41307751
51MP0010030_abnormal_orbit_morphology1.40595357
52MP0005330_cardiomyopathy1.40143361
53MP0006292_abnormal_olfactory_placode1.37255638
54MP0003718_maternal_effect1.36943852
55MP0000685_abnormal_immune_system1.36739393
56MP0010352_gastrointestinal_tract_polyps1.36641439
57MP0001697_abnormal_embryo_size1.35855435
58MP0006035_abnormal_mitochondrial_morpho1.30168168
59MP0002429_abnormal_blood_cell1.29301352
60MP0001727_abnormal_embryo_implantation1.29070564
61MP0000049_abnormal_middle_ear1.27540386
62MP0005671_abnormal_response_to1.27086297
63MP0006054_spinal_hemorrhage1.26706865
64MP0000749_muscle_degeneration1.25586336
65MP0000733_abnormal_muscle_development1.23397499
66MP0000003_abnormal_adipose_tissue1.22903128
67MP0005380_embryogenesis_phenotype1.22830589
68MP0001672_abnormal_embryogenesis/_devel1.22830589
69MP0004147_increased_porphyrin_level1.22006809
70MP0001835_abnormal_antigen_presentation1.21236095
71MP0002163_abnormal_gland_morphology1.17948393
72MP0009053_abnormal_anal_canal1.17678083
73MP0000716_abnormal_immune_system1.16712725
74MP0003567_abnormal_fetal_cardiomyocyte1.15433561
75MP0001873_stomach_inflammation1.12305115
76MP0003984_embryonic_growth_retardation1.12163890
77MP0000358_abnormal_cell_content/1.12042077
78MP0000759_abnormal_skeletal_muscle1.11329170
79MP0001849_ear_inflammation1.11017580
80MP0000681_abnormal_thyroid_gland1.10331531
81MP0003656_abnormal_erythrocyte_physiolo1.10283563
82MP0005670_abnormal_white_adipose1.09842578
83MP0002088_abnormal_embryonic_growth/wei1.08773567
84MP0002796_impaired_skin_barrier1.07082120
85MP0001800_abnormal_humoral_immune1.06767463
86MP0000858_altered_metastatic_potential1.04148912
87MP0010307_abnormal_tumor_latency1.02793207
88MP0002085_abnormal_embryonic_tissue1.01901742
89MP0002420_abnormal_adaptive_immunity0.99465098
90MP0005174_abnormal_tail_pigmentation0.99039851
91MP0001881_abnormal_mammary_gland0.98658804
92MP0008877_abnormal_DNA_methylation0.96571578
93MP0001819_abnormal_immune_cell0.96291043
94MP0008438_abnormal_cutaneous_collagen0.95811370
95MP0003315_abnormal_perineum_morphology0.95484466
96MP0002095_abnormal_skin_pigmentation0.94879896
97MP0009785_altered_susceptibility_to0.94517784
98MP0001764_abnormal_homeostasis0.92322416
99MP0002086_abnormal_extraembryonic_tissu0.91403813
100MP0000465_gastrointestinal_hemorrhage0.90606695
101MP0000343_altered_response_to0.90040819
102MP0002166_altered_tumor_susceptibility0.89930145
103MP0005025_abnormal_response_to0.88469556
104MP0003942_abnormal_urinary_system0.87716723
105MP0002405_respiratory_system_inflammati0.86491240
106MP0000747_muscle_weakness0.85182227
107MP0010155_abnormal_intestine_physiology0.84414687
108MP0003866_abnormal_defecation0.84330963
109MP0002084_abnormal_developmental_patter0.83794152
110MP0002723_abnormal_immune_serum0.83777621
111MP0000762_abnormal_tongue_morphology0.83348329
112MP0002269_muscular_atrophy0.82119959
113MP0002452_abnormal_antigen_presenting0.80748512
114MP0001293_anophthalmia0.80422125
115MP0009250_abnormal_appendicular_skeleto0.80344942
116MP0004197_abnormal_fetal_growth/weight/0.80296402
117MP0002177_abnormal_outer_ear0.80103223
118MP0008789_abnormal_olfactory_epithelium0.79820610
119MP0005266_abnormal_metabolism0.79457411
120MP0009672_abnormal_birth_weight0.79395450
121MP0009697_abnormal_copulation0.78760940
122MP0004381_abnormal_hair_follicle0.77092781
123MP0000751_myopathy0.75658739
124MP0005375_adipose_tissue_phenotype0.73955225
125MP0000477_abnormal_intestine_morphology0.73514600
126MP0004133_heterotaxia0.72163728
127MP0001529_abnormal_vocalization0.71282825
128MP0002160_abnormal_reproductive_system0.70940344
129MP0009840_abnormal_foam_cell0.69938233
130MP0002006_tumorigenesis0.69618404
131MP0003221_abnormal_cardiomyocyte_apopto0.69534693
132MP0002210_abnormal_sex_determination0.68232218
133MP0001188_hyperpigmentation0.66122065
134MP0002060_abnormal_skin_morphology0.65786885
135MP0002653_abnormal_ependyma_morphology0.65504296
136MP0005000_abnormal_immune_tolerance0.64818522
137MP0001145_abnormal_male_reproductive0.64657011
138MP0002938_white_spotting0.62640551
139MP0010771_integument_phenotype0.62256059
140MP0003385_abnormal_body_wall0.61753166
141MP0005621_abnormal_cell_physiology0.60791657
142MP0000467_abnormal_esophagus_morphology0.60685187
143MP0003453_abnormal_keratinocyte_physiol0.60181588
144MP0003436_decreased_susceptibility_to0.59767462
145MP0001919_abnormal_reproductive_system0.59720095
146MP0004782_abnormal_surfactant_physiolog0.59661377
147MP0005501_abnormal_skin_physiology0.59234128
148MP0001905_abnormal_dopamine_level0.57603123
149MP0005464_abnormal_platelet_physiology0.57414994
150MP0005384_cellular_phenotype0.56921328
151MP0005023_abnormal_wound_healing0.56707771
152MP0009931_abnormal_skin_appearance0.56495729
153MP0005394_taste/olfaction_phenotype0.56433407
154MP0005499_abnormal_olfactory_system0.56433407
155MP0005389_reproductive_system_phenotype0.56370530
156MP0002970_abnormal_white_adipose0.55945854
157MP0002114_abnormal_axial_skeleton0.55831272

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.64037278
2Abnormal number of erythroid precursors (HP:0012131)6.37913570
3Reticulocytopenia (HP:0001896)5.82384076
4Macrocytic anemia (HP:0001972)4.33057955
5Birth length less than 3rd percentile (HP:0003561)4.13309934
6Oral leukoplakia (HP:0002745)4.11922313
7Aplastic anemia (HP:0001915)4.07212170
8Pallor (HP:0000980)3.98386118
9Ragged-red muscle fibers (HP:0003200)3.52215826
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.49642982
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.49642982
12Hepatocellular necrosis (HP:0001404)3.44944312
13Thrombocytosis (HP:0001894)3.33559161
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.24092921
15Colon cancer (HP:0003003)3.23572168
16Testicular atrophy (HP:0000029)3.15788440
17Hepatic necrosis (HP:0002605)3.13301475
18Breast hypoplasia (HP:0003187)3.11175005
19Increased serum lactate (HP:0002151)3.09836136
20Mitochondrial inheritance (HP:0001427)3.00752812
21Type I transferrin isoform profile (HP:0003642)2.96325141
22Rough bone trabeculation (HP:0100670)2.93364893
23Cerebral edema (HP:0002181)2.89683500
24Increased CSF lactate (HP:0002490)2.89239021
25Cerebral hypomyelination (HP:0006808)2.86871256
263-Methylglutaconic aciduria (HP:0003535)2.85136557
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.84723273
28Broad distal phalanx of finger (HP:0009836)2.82588351
29Abnormality of the umbilical cord (HP:0010881)2.82266548
30Hypokinesia (HP:0002375)2.82006339
31Truncus arteriosus (HP:0001660)2.80739331
32Abnormal gallbladder physiology (HP:0012438)2.77254210
33Cholecystitis (HP:0001082)2.77254210
34Abnormality of the anterior horn cell (HP:0006802)2.74920179
35Degeneration of anterior horn cells (HP:0002398)2.74920179
36Abnormality of the preputium (HP:0100587)2.74500544
37IgM deficiency (HP:0002850)2.73407443
38Acute necrotizing encephalopathy (HP:0006965)2.70607172
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69257086
40Multiple enchondromatosis (HP:0005701)2.67453582
41Abnormal mitochondria in muscle tissue (HP:0008316)2.63938517
42Increased hepatocellular lipid droplets (HP:0006565)2.61253125
43Abnormality of the fetal cardiovascular system (HP:0010948)2.60287118
44Abnormal umbilical cord blood vessels (HP:0011403)2.60287118
45Single umbilical artery (HP:0001195)2.60287118
46Reduced antithrombin III activity (HP:0001976)2.59464129
47Hyperthyroidism (HP:0000836)2.55674563
48Hypertensive crisis (HP:0100735)2.53994613
49Abnormality of reticulocytes (HP:0004312)2.53473442
50Absent thumb (HP:0009777)2.50254988
51Pancytopenia (HP:0001876)2.50152804
5211 pairs of ribs (HP:0000878)2.46246342
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44403004
54Chromsome breakage (HP:0040012)2.43956894
55Premature graying of hair (HP:0002216)2.43924329
56Vertebral compression fractures (HP:0002953)2.43850784
57Lipid accumulation in hepatocytes (HP:0006561)2.43253028
58Achilles tendon contracture (HP:0001771)2.43232660
59Increased serum pyruvate (HP:0003542)2.43080207
60Abnormality of glycolysis (HP:0004366)2.43080207
61Hypoplastic left heart (HP:0004383)2.42439406
62Meckel diverticulum (HP:0002245)2.41909045
63Patellar aplasia (HP:0006443)2.41646104
64Increased intramyocellular lipid droplets (HP:0012240)2.38459280
65Abnormality of the ileum (HP:0001549)2.37890786
66Carpal bone hypoplasia (HP:0001498)2.37589455
67Myelodysplasia (HP:0002863)2.37355921
68Exertional dyspnea (HP:0002875)2.34885483
69Lactic acidosis (HP:0003128)2.33205747
70Cellular immunodeficiency (HP:0005374)2.32345130
71Aplasia/Hypoplasia of the patella (HP:0006498)2.31716994
72Opisthotonus (HP:0002179)2.31616855
73Trismus (HP:0000211)2.27667802
74Myopathic facies (HP:0002058)2.26147008
75Acute encephalopathy (HP:0006846)2.25946214
76Bone marrow hypocellularity (HP:0005528)2.25694139
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24714172
78Double outlet right ventricle (HP:0001719)2.24453727
79Congenital malformation of the right heart (HP:0011723)2.24453727
80Medulloblastoma (HP:0002885)2.23146061
81Abnormalities of placenta or umbilical cord (HP:0001194)2.22236057
82Respiratory difficulties (HP:0002880)2.19924655
83Abnormality of chromosome stability (HP:0003220)2.17034420
84Exercise intolerance (HP:0003546)2.15208746
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14305951
86Abnormal protein N-linked glycosylation (HP:0012347)2.14305951
87Abnormal protein glycosylation (HP:0012346)2.14305951
88Abnormal glycosylation (HP:0012345)2.14305951
89Increased muscle lipid content (HP:0009058)2.13798702
90Neoplasm of head and neck (HP:0012288)2.11636637
91Esophageal neoplasm (HP:0100751)2.11636637
92Basal cell carcinoma (HP:0002671)2.10194376
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.09518769
94Neoplasm of the pancreas (HP:0002894)2.09491046
95Abnormality of pyrimidine metabolism (HP:0004353)2.07460077
96Microvesicular hepatic steatosis (HP:0001414)2.06556435
97Muscle fiber atrophy (HP:0100295)2.06395551
98Abnormality of the Achilles tendon (HP:0005109)2.06255106
99Abnormal lung lobation (HP:0002101)2.06175452
100Lymphoma (HP:0002665)2.04534079
101Progressive muscle weakness (HP:0003323)2.04501509
102Squamous cell carcinoma (HP:0002860)2.04123453
103Small intestinal stenosis (HP:0012848)2.03955865
104Duodenal stenosis (HP:0100867)2.03955865
105Poikiloderma (HP:0001029)2.03602852
106Horseshoe kidney (HP:0000085)2.02691537
107Septate vagina (HP:0001153)2.00965095
108Asplenia (HP:0001746)2.00418639
109Triphalangeal thumb (HP:0001199)1.99801584
110Abnormal trabecular bone morphology (HP:0100671)1.99605436
111Abnormality of the tricuspid valve (HP:0001702)1.99382309
112Premature ovarian failure (HP:0008209)1.99231579
113* Microretrognathia (HP:0000308)1.98581704
114Entropion (HP:0000621)1.98476725
115Abnormality of the distal phalanges of the toes (HP:0010182)1.98369066
116Sparse eyelashes (HP:0000653)1.97867769
117Fasciculations (HP:0002380)1.97453350
118Hypoplastic heart (HP:0001961)1.96538525
119Emotional lability (HP:0000712)1.95363316
120Respiratory failure (HP:0002878)1.93701708
121Elevated erythrocyte sedimentation rate (HP:0003565)1.90454148
122Tracheoesophageal fistula (HP:0002575)1.88680229
123Abnormality of T cell physiology (HP:0011840)1.88134518
124Renal Fanconi syndrome (HP:0001994)1.88047464
125Petechiae (HP:0000967)1.88037108
126Agnosia (HP:0010524)1.87169359
127Secondary amenorrhea (HP:0000869)1.87072038
128Distal lower limb muscle weakness (HP:0009053)1.86274021
129Progressive macrocephaly (HP:0004481)1.85847847
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.84938921
131Cholelithiasis (HP:0001081)1.84397561
132Leukodystrophy (HP:0002415)1.83148649
133Generalized amyotrophy (HP:0003700)1.83074010
134Type 2 muscle fiber atrophy (HP:0003554)1.82848383
135Hypoparathyroidism (HP:0000829)1.82825911
136Amaurosis fugax (HP:0100576)1.82201652
137Unilateral renal agenesis (HP:0000122)1.82189169
138Glossoptosis (HP:0000162)1.80149996
139Premature rupture of membranes (HP:0001788)1.79475870
140Rhabdomyolysis (HP:0003201)1.76943618
141Death in infancy (HP:0001522)1.75298235
142Abnormality of the gallbladder (HP:0005264)1.73214560
143Stridor (HP:0010307)1.69751239
144Reticulocytosis (HP:0001923)1.69249383
145Seborrheic dermatitis (HP:0001051)1.68823794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02599482
2VRK24.48978351
3WEE13.88966349
4NME23.59937713
5EIF2AK13.32606728
6IRAK33.30632555
7SMG13.23452007
8STK163.19205437
9CDC73.00852035
10TRIB32.60911150
11TESK22.34713416
12EIF2AK32.34402634
13ARAF2.23871339
14VRK12.20817544
15ACVR1B2.17196963
16TLK12.16809215
17SRPK11.94997154
18TSSK61.93688376
19MAP4K11.88200777
20PASK1.84732254
21NEK21.83410234
22RPS6KB21.83145186
23BCKDK1.74556366
24KDR1.70834894
25CDK71.62839203
26BRSK21.56989434
27NEK11.52116153
28PIM21.51105622
29EEF2K1.48450566
30PLK11.48386716
31TGFBR11.47810524
32PDK21.45741371
33AURKB1.43107504
34PBK1.40461342
35MKNK11.40422566
36SCYL21.36093329
37ATR1.35662203
38TTK1.34804644
39ABL21.34208504
40DYRK31.25637860
41NME11.24788648
42ICK1.23546609
43AURKA1.22313471
44FLT31.20768534
45LRRK21.20484963
46PLK41.17947301
47PAK41.17697550
48CCNB11.11791326
49STK101.10646775
50CSNK1G31.10266560
51MAP3K81.10233072
52RPS6KA41.09925771
53BRSK11.07600884
54PRKD31.06167497
55TAF11.06062639
56CDK41.05819460
57CDK81.03671294
58MAP3K111.01435537
59CDK190.98758648
60ZAP700.97292871
61GRK60.96448307
62BLK0.95836880
63BTK0.92652071
64MAPKAPK30.89979455
65ERN10.88091462
66SIK10.87993498
67MAP3K100.87928217
68IRAK20.87656574
69MKNK20.86615681
70MST1R0.84451048
71MST40.83861747
72MAP2K30.82310578
73CSNK1A1L0.81841920
74STK40.80181713
75TEC0.79710718
76CHEK20.78077274
77ILK0.78012266
78CSNK2A20.74857570
79EIF2AK20.74047162
80TESK10.74004346
81CHEK10.73400808
82PIM10.72260882
83PLK30.71997668
84PKN20.71193516
85CSNK2A10.70638001
86TAOK20.68532209
87PAK10.65291066
88KIT0.60889593
89CLK10.60721131
90PRPF4B0.60429149
91TXK0.57978137
92DAPK10.56848603
93CSF1R0.54655527
94RAF10.54368921
95CSNK1G10.53563096
96CSNK1G20.51974646
97MAPKAPK50.51859673
98CDK20.50967818
99SYK0.50641515
100PRKCI0.49989546
101TTN0.49061893
102CAMK2G0.47774322
103CDK11A0.47516551
104SIK30.46104324
105ATM0.44977965
106MAP2K60.44911057
107IRAK40.44460149
108RPS6KA50.43895556
109CDK140.42858233
110BRAF0.42703180
111CDK150.42443898
112LYN0.40550059
113CDK180.39638491
114MAP2K20.38162626
115AKT20.37198604
116TYK20.37000275
117MAP3K120.36663505
118CDK90.35974048
119MYLK0.34685463
120NLK0.34410789
121ZAK0.34225937
122DYRK20.33724992
123LMTK20.32710740
124PTK20.32699623
125IKBKB0.32286083
126RPS6KL10.31710688
127RPS6KC10.31710688
128RPS6KA60.31358263
129CDK10.31011927
130EPHA20.29800432
131MAP3K30.29193361
132MAPK110.29134295
133TAOK10.28925794
134DAPK30.28367795
135LIMK10.28185903
136MAP3K10.26800686
137MTOR0.25860368
138MUSK0.24968464

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.21449800
2DNA replication_Homo sapiens_hsa030305.01938440
3Mismatch repair_Homo sapiens_hsa034304.06886260
4Proteasome_Homo sapiens_hsa030503.77488840
5RNA polymerase_Homo sapiens_hsa030203.32319090
6Spliceosome_Homo sapiens_hsa030403.16282209
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07662367
8Base excision repair_Homo sapiens_hsa034103.05350892
9Nucleotide excision repair_Homo sapiens_hsa034202.77115607
10Homologous recombination_Homo sapiens_hsa034402.75271514
11Pyrimidine metabolism_Homo sapiens_hsa002402.71124304
12RNA transport_Homo sapiens_hsa030132.43167110
13One carbon pool by folate_Homo sapiens_hsa006702.33995678
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26015833
15Cell cycle_Homo sapiens_hsa041101.94609635
16Fanconi anemia pathway_Homo sapiens_hsa034601.77667489
17RNA degradation_Homo sapiens_hsa030181.66916397
18Parkinsons disease_Homo sapiens_hsa050121.66238503
19Non-homologous end-joining_Homo sapiens_hsa034501.64469119
20Oxidative phosphorylation_Homo sapiens_hsa001901.54230903
21Fatty acid elongation_Homo sapiens_hsa000621.43664676
22Basal transcription factors_Homo sapiens_hsa030221.40457005
23Sulfur relay system_Homo sapiens_hsa041221.40357784
24Purine metabolism_Homo sapiens_hsa002301.38963135
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.34983092
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32507114
27Huntingtons disease_Homo sapiens_hsa050161.27538651
28Protein export_Homo sapiens_hsa030601.21639542
29Folate biosynthesis_Homo sapiens_hsa007901.17089460
30Pentose phosphate pathway_Homo sapiens_hsa000301.16914343
31Primary immunodeficiency_Homo sapiens_hsa053401.14992277
32p53 signaling pathway_Homo sapiens_hsa041151.13980505
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.10996223
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.07704537
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07561375
36Biosynthesis of amino acids_Homo sapiens_hsa012301.07492026
37Sulfur metabolism_Homo sapiens_hsa009201.06078058
38Vibrio cholerae infection_Homo sapiens_hsa051101.05912623
39mRNA surveillance pathway_Homo sapiens_hsa030151.04921333
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00705073
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97587598
42Epstein-Barr virus infection_Homo sapiens_hsa051690.94929972
43Systemic lupus erythematosus_Homo sapiens_hsa053220.94656643
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90683387
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89339293
46Alzheimers disease_Homo sapiens_hsa050100.84902886
47Carbon metabolism_Homo sapiens_hsa012000.83351933
48Antigen processing and presentation_Homo sapiens_hsa046120.80113978
49Glutathione metabolism_Homo sapiens_hsa004800.78694336
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78241216
51Other glycan degradation_Homo sapiens_hsa005110.74074270
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72302434
53Selenocompound metabolism_Homo sapiens_hsa004500.72273882
54Herpes simplex infection_Homo sapiens_hsa051680.68580462
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.63218994
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62187420
57Viral carcinogenesis_Homo sapiens_hsa052030.56883540
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56398860
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56374619
60N-Glycan biosynthesis_Homo sapiens_hsa005100.55842627
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54725503
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54101813
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51482435
64Galactose metabolism_Homo sapiens_hsa000520.51414877
65Metabolic pathways_Homo sapiens_hsa011000.47881681
66Fructose and mannose metabolism_Homo sapiens_hsa000510.46744966
67HTLV-I infection_Homo sapiens_hsa051660.46480287
68Thyroid cancer_Homo sapiens_hsa052160.45489376
69Collecting duct acid secretion_Homo sapiens_hsa049660.43471265
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40870525
71Legionellosis_Homo sapiens_hsa051340.39323665
72Pyruvate metabolism_Homo sapiens_hsa006200.38423114
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37832282
74Non-small cell lung cancer_Homo sapiens_hsa052230.32292171
75Oocyte meiosis_Homo sapiens_hsa041140.32239075
76Synaptic vesicle cycle_Homo sapiens_hsa047210.32116398
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.31515818
78Prion diseases_Homo sapiens_hsa050200.29752033
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28707234
80Hematopoietic cell lineage_Homo sapiens_hsa046400.28006300
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27678785
82Pancreatic cancer_Homo sapiens_hsa052120.27676298
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27526495
84Measles_Homo sapiens_hsa051620.26527376
85Arginine and proline metabolism_Homo sapiens_hsa003300.26392411
86Apoptosis_Homo sapiens_hsa042100.26337379
87Chronic myeloid leukemia_Homo sapiens_hsa052200.26166399
88Shigellosis_Homo sapiens_hsa051310.25096216
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24394116
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23855249
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.23777681
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23370507
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23152481
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23046749
95Vitamin B6 metabolism_Homo sapiens_hsa007500.21423960
96Tyrosine metabolism_Homo sapiens_hsa003500.21060504
97Alcoholism_Homo sapiens_hsa050340.20327569
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19927442
99Salmonella infection_Homo sapiens_hsa051320.19753389
100VEGF signaling pathway_Homo sapiens_hsa043700.19299818
101Notch signaling pathway_Homo sapiens_hsa043300.18362766
102Steroid biosynthesis_Homo sapiens_hsa001000.17385145
103Lysosome_Homo sapiens_hsa041420.17030986
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16621462
105Fatty acid metabolism_Homo sapiens_hsa012120.15451613
106Cardiac muscle contraction_Homo sapiens_hsa042600.15012646
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12761282
108Bladder cancer_Homo sapiens_hsa052190.12070993
109Acute myeloid leukemia_Homo sapiens_hsa052210.11276293
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11113341
111Arachidonic acid metabolism_Homo sapiens_hsa005900.10743448
112Allograft rejection_Homo sapiens_hsa053300.09680977
113Hepatitis B_Homo sapiens_hsa051610.09650243
114Small cell lung cancer_Homo sapiens_hsa052220.09645674
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09538892
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.08813077
117Phenylalanine metabolism_Homo sapiens_hsa003600.07882902
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06757395
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06411458
120Asthma_Homo sapiens_hsa053100.05456694
121Viral myocarditis_Homo sapiens_hsa054160.04758980
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.04422273
123T cell receptor signaling pathway_Homo sapiens_hsa046600.03816365
124beta-Alanine metabolism_Homo sapiens_hsa004100.03752626
125Colorectal cancer_Homo sapiens_hsa052100.02803456

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