NAA15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.40323435
2nuclear pore organization (GO:0006999)5.26898947
3DNA unwinding involved in DNA replication (GO:0006268)4.57002951
4DNA double-strand break processing (GO:0000729)4.50483369
5mitotic sister chromatid cohesion (GO:0007064)4.39318174
6kinetochore organization (GO:0051383)4.11422956
7protein localization to kinetochore (GO:0034501)4.04184429
8mitotic metaphase plate congression (GO:0007080)4.02979252
9pore complex assembly (GO:0046931)3.95864884
10mitotic nuclear envelope disassembly (GO:0007077)3.95296741
11replication fork processing (GO:0031297)3.91231953
12maturation of SSU-rRNA (GO:0030490)3.79010349
13double-strand break repair via nonhomologous end joining (GO:0006303)3.73327666
14non-recombinational repair (GO:0000726)3.73327666
15DNA replication-dependent nucleosome organization (GO:0034723)3.72457526
16DNA replication-dependent nucleosome assembly (GO:0006335)3.72457526
17proteasome assembly (GO:0043248)3.70088907
18nuclear envelope disassembly (GO:0051081)3.69010853
19membrane disassembly (GO:0030397)3.69010853
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.67660748
21regulation of mitotic spindle checkpoint (GO:1903504)3.67660748
22DNA replication initiation (GO:0006270)3.65808587
23mitotic chromosome condensation (GO:0007076)3.63164720
24chromatin remodeling at centromere (GO:0031055)3.61539074
25regulation of RNA export from nucleus (GO:0046831)3.61279408
26protein localization to chromosome, centromeric region (GO:0071459)3.60562508
27establishment of integrated proviral latency (GO:0075713)3.59983625
28metaphase plate congression (GO:0051310)3.59023904
29negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.54189112
30negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54189112
31CENP-A containing nucleosome assembly (GO:0034080)3.53478378
32IMP biosynthetic process (GO:0006188)3.51457052
33DNA duplex unwinding (GO:0032508)3.51441594
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51261045
35DNA geometric change (GO:0032392)3.50596870
36DNA ligation (GO:0006266)3.49309213
37regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46693072
38ribosome assembly (GO:0042255)3.46459832
39DNA strand elongation involved in DNA replication (GO:0006271)3.40696342
40DNA replication-independent nucleosome organization (GO:0034724)3.39955023
41DNA replication-independent nucleosome assembly (GO:0006336)3.39955023
42regulation of DNA endoreduplication (GO:0032875)3.38882211
43telomere maintenance via telomerase (GO:0007004)3.37652153
44regulation of sister chromatid segregation (GO:0033045)3.35301673
45regulation of mitotic sister chromatid separation (GO:0010965)3.35301673
46regulation of mitotic sister chromatid segregation (GO:0033047)3.35301673
47kinetochore assembly (GO:0051382)3.34702078
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.34044194
49heterochromatin organization (GO:0070828)3.33599655
50sister chromatid segregation (GO:0000819)3.31994608
51mitotic spindle assembly checkpoint (GO:0007094)3.30793260
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.28400716
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28400716
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28178752
55isotype switching (GO:0045190)3.28178752
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28178752
57histone exchange (GO:0043486)3.27872364
58folic acid-containing compound biosynthetic process (GO:0009396)3.25344443
59DNA catabolic process, exonucleolytic (GO:0000738)3.24043612
60pre-miRNA processing (GO:0031054)3.23657591
61DNA topological change (GO:0006265)3.22476651
62regulation of spindle organization (GO:0090224)3.22240339
63DNA strand elongation (GO:0022616)3.21819225
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21665510
65mitotic sister chromatid segregation (GO:0000070)3.19650581
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18781803
67regulation of histone H3-K9 methylation (GO:0051570)3.18726423
68IMP metabolic process (GO:0046040)3.17017423
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.16099512
70nucleobase biosynthetic process (GO:0046112)3.15360147
71negative regulation of DNA recombination (GO:0045910)3.14488020
72synapsis (GO:0007129)3.13410519
73RNA-dependent DNA replication (GO:0006278)3.13392246
74meiotic chromosome segregation (GO:0045132)3.12820480
75histone mRNA metabolic process (GO:0008334)3.12499530
76DNA replication checkpoint (GO:0000076)3.12086481
77telomere maintenance via semi-conservative replication (GO:0032201)3.11736914
78positive regulation of chromosome segregation (GO:0051984)3.11483242
79mitotic recombination (GO:0006312)3.09254843
80mitotic G2/M transition checkpoint (GO:0044818)3.08315508
81ATP-dependent chromatin remodeling (GO:0043044)3.07373074
82formation of translation preinitiation complex (GO:0001731)3.07295140
83negative regulation of RNA splicing (GO:0033119)3.07103706
84establishment of chromosome localization (GO:0051303)3.06429477
85response to X-ray (GO:0010165)3.04301104
86maturation of 5.8S rRNA (GO:0000460)3.03789295
87somatic recombination of immunoglobulin gene segments (GO:0016447)3.03425154
88chromatin assembly or disassembly (GO:0006333)3.01991800
89negative regulation of mRNA processing (GO:0050686)3.01288123
90chromatin assembly (GO:0031497)3.01077894
91regulation of centriole replication (GO:0046599)3.00371391
92histone H2A acetylation (GO:0043968)3.00076095
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98721597
94mitochondrial RNA metabolic process (GO:0000959)2.98624855
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98303607
96positive regulation of mitotic sister chromatid separation (GO:1901970)2.98303607
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98303607
98DNA conformation change (GO:0071103)2.98279678
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97555363
100telomere maintenance via recombination (GO:0000722)2.97544464
101regulation of centrosome cycle (GO:0046605)2.95965665
102regulation of helicase activity (GO:0051095)2.95131266
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94917695
104ribosome biogenesis (GO:0042254)2.92981531
105ribosomal large subunit biogenesis (GO:0042273)2.92417380
106translesion synthesis (GO:0019985)2.91909914
107double-strand break repair via homologous recombination (GO:0000724)2.91690284
108spindle checkpoint (GO:0031577)2.91586271
109recombinational repair (GO:0000725)2.91422821
110regulation of centrosome duplication (GO:0010824)2.91271592
111RNA splicing, via transesterification reactions (GO:0000375)2.90728567
112DNA damage response, detection of DNA damage (GO:0042769)2.90519648
113mRNA splicing, via spliceosome (GO:0000398)2.89990862
114RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89990862
115negative regulation of histone methylation (GO:0031061)2.89218636
116nuclear envelope organization (GO:0006998)2.87989941
117transcription from mitochondrial promoter (GO:0006390)2.87675486
118protein K6-linked ubiquitination (GO:0085020)2.87233408
119sister chromatid cohesion (GO:0007062)2.86795218
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86406708
121purine nucleobase biosynthetic process (GO:0009113)2.86092843
122cullin deneddylation (GO:0010388)2.85918402
123ribonucleoprotein complex biogenesis (GO:0022613)2.85790979
124termination of RNA polymerase II transcription (GO:0006369)2.84787692
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.83900855
126mRNA transport (GO:0051028)2.83352583
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81681814
128translational termination (GO:0006415)2.81609532
129alternative mRNA splicing, via spliceosome (GO:0000380)2.80995543
130negative regulation of DNA repair (GO:0045738)2.80874981
131regulation of mitotic spindle organization (GO:0060236)2.80138179
132regulation of chromosome segregation (GO:0051983)2.79146153
133mitotic spindle checkpoint (GO:0071174)2.78865158
134protein localization to chromosome (GO:0034502)2.78237406
135spindle assembly checkpoint (GO:0071173)2.77851771
136negative regulation of chromosome segregation (GO:0051985)2.77685210
137negative regulation of mRNA metabolic process (GO:1903312)2.77221802
138attachment of spindle microtubules to kinetochore (GO:0008608)2.75155919
139telomere maintenance via telomere lengthening (GO:0010833)2.74774367
140mRNA stabilization (GO:0048255)2.74505590
141RNA stabilization (GO:0043489)2.74505590
142viral transcription (GO:0019083)2.74010404
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.73966960
144negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73966960
145negative regulation of sister chromatid segregation (GO:0033046)2.73966960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.34657365
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.46666731
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.32601759
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.55823846
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12608678
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.01055934
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.84717128
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78605935
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76980291
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66527483
11AR_21909140_ChIP-Seq_LNCAP_Human2.48457225
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.42461871
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37007341
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.30650073
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21609834
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.15787307
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.13709446
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11255667
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09121246
20XRN2_22483619_ChIP-Seq_HELA_Human2.08556739
21MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02004866
22E2F7_22180533_ChIP-Seq_HELA_Human10.4338857
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98989093
24ELK1_19687146_ChIP-ChIP_HELA_Human1.94367194
25* VDR_23849224_ChIP-Seq_CD4+_Human1.93676038
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.93510735
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92983400
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89940964
29ZNF274_21170338_ChIP-Seq_K562_Hela1.82928691
30FUS_26573619_Chip-Seq_HEK293_Human1.82376169
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81108723
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80626001
33MYC_22102868_ChIP-Seq_BL_Human1.78357134
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.76582114
35TTF2_22483619_ChIP-Seq_HELA_Human1.76411412
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75263082
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70813240
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.67085063
39FOXP3_21729870_ChIP-Seq_TREG_Human1.60467391
40VDR_22108803_ChIP-Seq_LS180_Human1.57305581
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56555288
42DCP1A_22483619_ChIP-Seq_HELA_Human1.54157524
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53363672
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53265780
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48508367
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46715376
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45780257
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44459080
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43996248
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43829923
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43136849
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42623059
53KDM5A_27292631_Chip-Seq_BREAST_Human1.41124320
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38944118
55CIITA_25753668_ChIP-Seq_RAJI_Human1.38339276
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36433307
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35877548
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34704027
59TAF15_26573619_Chip-Seq_HEK293_Human1.33403269
60GABP_19822575_ChIP-Seq_HepG2_Human1.30508836
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28862265
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.28088441
63IGF1R_20145208_ChIP-Seq_DFB_Human1.26608703
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26336188
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25909886
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25297439
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25191786
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22254485
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.22007058
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21802432
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20312457
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19000988
73* P300_19829295_ChIP-Seq_ESCs_Human1.18832877
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17280128
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13658458
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13631252
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11266237
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11157310
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09641383
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09641383
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09641383
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09107628
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08626274
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.07979846
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07515703
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07275187
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05206518
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04343027
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03771487
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.03202867
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01606958
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01514899
93TFEB_21752829_ChIP-Seq_HELA_Human1.01296975
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01018265
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98381715
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98184592
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97616805
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96793692
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96657639
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.96488854
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96250601
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95895106
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95831941
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94084263
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93626222
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91886937
107CHD1_26751641_Chip-Seq_LNCaP_Human0.91737098
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91732568
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88686377
110MYC_18940864_ChIP-ChIP_HL60_Human0.88587909
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87737786
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87258900
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.86297106
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.85560298
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85498409
116PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84140376
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84072521
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83402927
119NFE2_27457419_Chip-Seq_LIVER_Mouse0.83066554
120EWS_26573619_Chip-Seq_HEK293_Human0.81969676
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80136499
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79964998
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79543680
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79533331
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.79313945
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78407760
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78379364
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78320895
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78083888
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77211286
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74348116
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74263521
133IRF1_19129219_ChIP-ChIP_H3396_Human0.73971561
134ER_23166858_ChIP-Seq_MCF-7_Human0.73563932
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73403845
136GBX2_23144817_ChIP-Seq_PC3_Human0.73358496
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72145585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.00350721
2MP0003693_abnormal_embryo_hatching3.99308015
3MP0003111_abnormal_nucleus_morphology3.69224076
4MP0008057_abnormal_DNA_replication3.64655565
5MP0004957_abnormal_blastocyst_morpholog3.50210231
6MP0003077_abnormal_cell_cycle3.24485695
7MP0008058_abnormal_DNA_repair2.69440787
8MP0003123_paternal_imprinting2.50191019
9MP0008007_abnormal_cellular_replicative2.43127063
10MP0003718_maternal_effect2.29396402
11MP0008932_abnormal_embryonic_tissue2.26767728
12MP0010352_gastrointestinal_tract_polyps2.19213678
13MP0001730_embryonic_growth_arrest2.15201537
14MP0009697_abnormal_copulation2.15180124
15MP0002396_abnormal_hematopoietic_system2.06916020
16MP0008877_abnormal_DNA_methylation2.04974166
17MP0000350_abnormal_cell_proliferation2.01448029
18MP0005076_abnormal_cell_differentiation1.89810095
19MP0010307_abnormal_tumor_latency1.83755173
20MP0005380_embryogenesis_phenotype1.82657913
21MP0001672_abnormal_embryogenesis/_devel1.82657913
22MP0004197_abnormal_fetal_growth/weight/1.79718412
23MP0002084_abnormal_developmental_patter1.76099637
24MP0003890_abnormal_embryonic-extraembry1.75584451
25MP0003121_genomic_imprinting1.72687012
26MP0003567_abnormal_fetal_cardiomyocyte1.71613262
27MP0004808_abnormal_hematopoietic_stem1.70928688
28MP0001697_abnormal_embryo_size1.68489472
29MP0003984_embryonic_growth_retardation1.67774223
30MP0002088_abnormal_embryonic_growth/wei1.65495589
31MP0002085_abnormal_embryonic_tissue1.62670360
32MP0000537_abnormal_urethra_morphology1.60523773
33MP0003941_abnormal_skin_development1.60215125
34MP0000372_irregular_coat_pigmentation1.59364139
35MP0001293_anophthalmia1.58830551
36MP0006072_abnormal_retinal_apoptosis1.55825186
37MP0003786_premature_aging1.52391436
38MP0002086_abnormal_extraembryonic_tissu1.52062497
39MP0002254_reproductive_system_inflammat1.51892141
40MP0010030_abnormal_orbit_morphology1.41099316
41MP0002080_prenatal_lethality1.39220203
42MP0000490_abnormal_crypts_of1.38803036
43MP0009053_abnormal_anal_canal1.33961881
44MP0003937_abnormal_limbs/digits/tail_de1.30041076
45MP0000647_abnormal_sebaceous_gland1.23506126
46MP0006035_abnormal_mitochondrial_morpho1.23065298
47MP0000733_abnormal_muscle_development1.20493912
48MP0000383_abnormal_hair_follicle1.20386600
49MP0005367_renal/urinary_system_phenotyp1.20252784
50MP0000516_abnormal_urinary_system1.20252784
51MP0008995_early_reproductive_senescence1.19624495
52MP0003315_abnormal_perineum_morphology1.18499636
53MP0000313_abnormal_cell_death1.17734461
54MP0006292_abnormal_olfactory_placode1.12434874
55MP0002697_abnormal_eye_size1.12142915
56MP0000569_abnormal_digit_pigmentation1.10651218
57MP0001286_abnormal_eye_development1.08501596
58MP0009672_abnormal_birth_weight1.07629363
59MP0000428_abnormal_craniofacial_morphol1.07549437
60MP0002210_abnormal_sex_determination1.06603438
61MP0000703_abnormal_thymus_morphology1.05773041
62MP0002092_abnormal_eye_morphology1.04637288
63MP0000432_abnormal_head_morphology1.04257852
64MP0003763_abnormal_thymus_physiology1.04107552
65MP0009703_decreased_birth_body1.03904886
66MP0001188_hyperpigmentation1.03047568
67MP0010678_abnormal_skin_adnexa1.01127522
68MP0002019_abnormal_tumor_incidence1.00517483
69MP0001661_extended_life_span0.97586728
70MP0002111_abnormal_tail_morphology0.95332701
71MP0000358_abnormal_cell_content/0.94021344
72MP0003755_abnormal_palate_morphology0.93389186
73MP0000566_synostosis0.93182802
74MP0003935_abnormal_craniofacial_develop0.92524138
75MP0003119_abnormal_digestive_system0.92277680
76MP0005397_hematopoietic_system_phenotyp0.92131897
77MP0001545_abnormal_hematopoietic_system0.92131897
78MP0006054_spinal_hemorrhage0.91489418
79MP0005253_abnormal_eye_physiology0.90466301
80MP0001145_abnormal_male_reproductive0.90218262
81MP0005187_abnormal_penis_morphology0.90158975
82MP0005395_other_phenotype0.89188748
83MP0001529_abnormal_vocalization0.88528580
84MP0002877_abnormal_melanocyte_morpholog0.88514724
85MP0002102_abnormal_ear_morphology0.87477170
86MP0000427_abnormal_hair_cycle0.87424878
87MP0003705_abnormal_hypodermis_morpholog0.85775160
88MP0003806_abnormal_nucleotide_metabolis0.85657262
89MP0006036_abnormal_mitochondrial_physio0.84952865
90MP0003221_abnormal_cardiomyocyte_apopto0.84556865
91MP0003566_abnormal_cell_adhesion0.84528942
92MP0005075_abnormal_melanosome_morpholog0.84053884
93MP0001915_intracranial_hemorrhage0.83076606
94MP0008789_abnormal_olfactory_epithelium0.83048143
95MP0003943_abnormal_hepatobiliary_system0.83015471
96MP0003115_abnormal_respiratory_system0.81241640
97MP0004215_abnormal_myocardial_fiber0.80893387
98MP0002282_abnormal_trachea_morphology0.79430036
99MP0004147_increased_porphyrin_level0.79300658
100MP0004133_heterotaxia0.78939627
101MP0001929_abnormal_gametogenesis0.78763213
102MP0002398_abnormal_bone_marrow0.77667651
103MP0002160_abnormal_reproductive_system0.76578372
104MP0003136_yellow_coat_color0.76379055
105MP0005391_vision/eye_phenotype0.76092430
106MP0002837_dystrophic_cardiac_calcinosis0.75406006
107MP0002098_abnormal_vibrissa_morphology0.73838646
108MP0003787_abnormal_imprinting0.73552464
109MP0002090_abnormal_vision0.73457122
110MP0005084_abnormal_gallbladder_morpholo0.72876866
111MP0001119_abnormal_female_reproductive0.72616585
112MP0009333_abnormal_splenocyte_physiolog0.72201344
113MP0002114_abnormal_axial_skeleton0.71877125
114MP0002938_white_spotting0.71769211
115MP0002925_abnormal_cardiovascular_devel0.71740862
116MP0002234_abnormal_pharynx_morphology0.71199935
117MP0003828_pulmonary_edema0.71104571
118MP0000653_abnormal_sex_gland0.70246433
119MP0001177_atelectasis0.70228428
120MP0005408_hypopigmentation0.69665732
121MP0000631_abnormal_neuroendocrine_gland0.69537047
122MP0002009_preneoplasia0.69293734
123MP0002722_abnormal_immune_system0.68611165
124MP0003385_abnormal_body_wall0.68208591
125MP0010234_abnormal_vibrissa_follicle0.68149111
126MP0002249_abnormal_larynx_morphology0.67751870
127MP0003950_abnormal_plasma_membrane0.67529624
128MP0003646_muscle_fatigue0.67510637
129MP0001485_abnormal_pinna_reflex0.67278979
130MP0009278_abnormal_bone_marrow0.67145859
131MP0003861_abnormal_nervous_system0.66884007
132MP0002932_abnormal_joint_morphology0.66627668
133MP0002233_abnormal_nose_morphology0.66460634
134MP0000049_abnormal_middle_ear0.66216516
135MP0002751_abnormal_autonomic_nervous0.66209554
136MP0001216_abnormal_epidermal_layer0.64351331
137MP0005501_abnormal_skin_physiology0.64134621
138MP0000467_abnormal_esophagus_morphology0.63658215
139MP0003938_abnormal_ear_development0.62801008
140MP0002177_abnormal_outer_ear0.62607064

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.60742386
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32354945
3Selective tooth agenesis (HP:0001592)3.15994965
4Volvulus (HP:0002580)2.93401343
5Reticulocytopenia (HP:0001896)2.89669433
6Abnormality of chromosome stability (HP:0003220)2.89289099
7Ectopic kidney (HP:0000086)2.79121534
8Colon cancer (HP:0003003)2.78732897
9Proximal placement of thumb (HP:0009623)2.75666558
10Deviation of the thumb (HP:0009603)2.74155367
11Glioma (HP:0009733)2.72049576
12Intestinal atresia (HP:0011100)2.70527458
13Abnormal number of incisors (HP:0011064)2.69630700
14Abnormality of the preputium (HP:0100587)2.62370548
15Medulloblastoma (HP:0002885)2.60136292
16Abnormality of the labia minora (HP:0012880)2.58016117
17Supernumerary spleens (HP:0009799)2.53856542
18Meckel diverticulum (HP:0002245)2.53299036
19Birth length less than 3rd percentile (HP:0003561)2.52401735
20Neoplasm of the adrenal cortex (HP:0100641)2.51645009
21Degeneration of anterior horn cells (HP:0002398)2.51621410
22Abnormality of the anterior horn cell (HP:0006802)2.51621410
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.50647413
24Ependymoma (HP:0002888)2.49943746
25Absent radius (HP:0003974)2.45880214
2611 pairs of ribs (HP:0000878)2.38576482
27Abnormality of the ileum (HP:0001549)2.36961074
28Absent forearm bone (HP:0003953)2.32166622
29Aplasia involving forearm bones (HP:0009822)2.32166622
30Prominent nose (HP:0000448)2.30569454
31Facial hemangioma (HP:0000329)2.30302267
32Missing ribs (HP:0000921)2.29871363
33Myelodysplasia (HP:0002863)2.28404832
34Clubbing of toes (HP:0100760)2.25509128
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22883111
36Short 4th metacarpal (HP:0010044)2.22883111
37Duodenal stenosis (HP:0100867)2.22731119
38Small intestinal stenosis (HP:0012848)2.22731119
39Patellar aplasia (HP:0006443)2.22325961
40Spinal cord lesions (HP:0100561)2.22249059
41Syringomyelia (HP:0003396)2.22249059
42Breast hypoplasia (HP:0003187)2.22137565
43Biliary tract neoplasm (HP:0100574)2.21102566
44Abnormality of methionine metabolism (HP:0010901)2.17823066
45Neoplasm of the adrenal gland (HP:0100631)2.17685076
46Increased nuchal translucency (HP:0010880)2.17218906
47Aplasia/Hypoplasia of the patella (HP:0006498)2.16054970
48Rhabdomyosarcoma (HP:0002859)2.15910324
49Agnosia (HP:0010524)2.15903918
50Basal cell carcinoma (HP:0002671)2.13039149
51Abnormality of glycolysis (HP:0004366)2.12617501
52Esophageal atresia (HP:0002032)2.10031805
53Small hand (HP:0200055)2.07592778
54Pancreatic islet-cell hyperplasia (HP:0004510)2.06846819
55Absent thumb (HP:0009777)2.06637360
56Long eyelashes (HP:0000527)2.03442674
57Abnormal lung lobation (HP:0002101)2.02387532
58Abnormality of cells of the erythroid lineage (HP:0012130)2.02141698
59Impulsivity (HP:0100710)2.00229439
60Nephroblastoma (Wilms tumor) (HP:0002667)1.98558429
61Abnormality of the pons (HP:0007361)1.97367255
62Methylmalonic acidemia (HP:0002912)1.96707121
63Multiple enchondromatosis (HP:0005701)1.96137878
64Oral leukoplakia (HP:0002745)1.95577340
65Acute myeloid leukemia (HP:0004808)1.95370456
66Embryonal renal neoplasm (HP:0011794)1.94949790
67Abnormality of the duodenum (HP:0002246)1.94606413
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92962691
69Pelvic girdle muscle weakness (HP:0003749)1.92244820
70Squamous cell carcinoma (HP:0002860)1.91912631
71Abnormality of the fingertips (HP:0001211)1.91501962
72Pallor (HP:0000980)1.90981368
73Neoplasm of the colon (HP:0100273)1.90934982
74Neoplasm of the pancreas (HP:0002894)1.90665566
75Supernumerary ribs (HP:0005815)1.90271549
76Abnormal hair whorl (HP:0010721)1.89732715
77Acute encephalopathy (HP:0006846)1.89514240
78Horseshoe kidney (HP:0000085)1.88817270
79Cortical dysplasia (HP:0002539)1.88467144
80Skull defect (HP:0001362)1.88031893
81Abnormal number of erythroid precursors (HP:0012131)1.87880903
82Atresia of the external auditory canal (HP:0000413)1.87493823
83Increased serum pyruvate (HP:0003542)1.86240104
84Carpal bone hypoplasia (HP:0001498)1.86090942
85Sloping forehead (HP:0000340)1.85894864
86Increased hepatocellular lipid droplets (HP:0006565)1.85693228
87Triphalangeal thumb (HP:0001199)1.85338447
88Duplicated collecting system (HP:0000081)1.85001464
89Supernumerary bones of the axial skeleton (HP:0009144)1.84278788
90Neoplasm of the oral cavity (HP:0100649)1.83418295
91Hypoplasia of the pons (HP:0012110)1.83392945
92Progressive inability to walk (HP:0002505)1.81891427
93Gastrointestinal atresia (HP:0002589)1.81645332
94Short thumb (HP:0009778)1.80728986
95Choanal atresia (HP:0000453)1.80605280
96Acute necrotizing encephalopathy (HP:0006965)1.80561817
97Amaurosis fugax (HP:0100576)1.80490332
98Abnormality of serum amino acid levels (HP:0003112)1.80426465
99Rib fusion (HP:0000902)1.79852595
100Pancreatic cysts (HP:0001737)1.79625245
101Oligodactyly (HP:0012165)1.78321310
102Deep philtrum (HP:0002002)1.77248180
103Neoplasm of striated muscle (HP:0009728)1.76789648
104Lip pit (HP:0100267)1.75767352
105Pancreatic fibrosis (HP:0100732)1.75710698
106Sensory axonal neuropathy (HP:0003390)1.75703035
107Aplasia/hypoplasia of the humerus (HP:0006507)1.75431586
108Breast carcinoma (HP:0003002)1.75333025
109Postnatal microcephaly (HP:0005484)1.74799924
110Ovarian neoplasm (HP:0100615)1.73461780
111Bifid tongue (HP:0010297)1.73087071
112Premature graying of hair (HP:0002216)1.73024509
113Abnormality of the calcaneus (HP:0008364)1.72692815
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.72681971
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72532461
116Abnormality of alanine metabolism (HP:0010916)1.72532461
117Hyperalaninemia (HP:0003348)1.72532461
118Sparse lateral eyebrow (HP:0005338)1.72154169
119Dandy-Walker malformation (HP:0001305)1.71852816
120Microtia (HP:0008551)1.71772001
121Increased CSF lactate (HP:0002490)1.71362073
122Abnormality of the carotid arteries (HP:0005344)1.70666896
123Tracheoesophageal fistula (HP:0002575)1.70211682
124Abnormality of the astrocytes (HP:0100707)1.69688611
125Astrocytoma (HP:0009592)1.69688611
126Gastrointestinal carcinoma (HP:0002672)1.69234817
127Malignant gastrointestinal tract tumors (HP:0006749)1.69234817
128Abnormality of the renal collecting system (HP:0004742)1.68622019
129Oligodactyly (hands) (HP:0001180)1.67872722
130Shoulder girdle muscle weakness (HP:0003547)1.67295702
131High pitched voice (HP:0001620)1.67275895
132Preaxial hand polydactyly (HP:0001177)1.66787287
133Asplenia (HP:0001746)1.66628705
134Increased density of long bones (HP:0006392)1.66316781
135Anal stenosis (HP:0002025)1.66310992
136Aqueductal stenosis (HP:0002410)1.65992746
137Hyperglycinemia (HP:0002154)1.65869634
138Urethral obstruction (HP:0000796)1.65299022
139Abnormality of the hip-girdle musculature (HP:0001445)1.65123220
140Abnormality of the musculature of the pelvis (HP:0001469)1.65123220
141Hypoplastic female external genitalia (HP:0012815)1.64554455
142Cafe-au-lait spot (HP:0000957)1.62794879
143Progressive macrocephaly (HP:0004481)1.61758391
144Abnormality of the incisor (HP:0000676)1.60713398
145Lipid accumulation in hepatocytes (HP:0006561)1.59739897
146Embryonal neoplasm (HP:0002898)1.58598406
147Hypoplastic labia majora (HP:0000059)1.57583428
148True hermaphroditism (HP:0010459)1.57468939
149Increased serum lactate (HP:0002151)1.57437143
150Labial hypoplasia (HP:0000066)1.54591688
151Septo-optic dysplasia (HP:0100842)1.52836666
152Astigmatism (HP:0000483)1.52268566
153Arteriovenous malformation (HP:0100026)1.51003643
154Methylmalonic aciduria (HP:0012120)1.49597318
155Cerebral edema (HP:0002181)1.47555187
156Type I transferrin isoform profile (HP:0003642)1.47406158
157Abnormality of serine family amino acid metabolism (HP:0010894)1.47190947
158Abnormality of glycine metabolism (HP:0010895)1.47190947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.39708072
2WEE13.89629699
3MKNK13.80140955
4CDK123.59056061
5MKNK23.16814322
6SRPK13.15591311
7TRIM283.12636492
8NEK22.61173323
9TTK2.27157273
10WNK32.23046682
11NUAK12.15397327
12BUB12.09616429
13TNIK2.08357807
14TSSK62.05813918
15FRK1.97687956
16PNCK1.97376360
17BRD41.95211655
18CDK71.87025315
19EIF2AK11.85162573
20BMPR1B1.80966195
21ATR1.78429647
22PLK11.72292277
23PLK31.68867622
24STK101.66701175
25BRSK21.66396643
26CDK41.63529453
27TLK11.62191732
28AURKB1.61684753
29PLK41.58969020
30RPS6KB21.58047728
31PASK1.56557642
32CHEK11.53895350
33RPS6KA41.50857122
34CHEK21.47836034
35EIF2AK31.45162802
36CDK61.43517823
37TAF11.42786373
38MAP4K21.39864034
39PLK21.38938942
40EPHA21.36259973
41STK31.36194248
42MAP3K81.32327650
43EEF2K1.31781656
44STK41.31023494
45ATM1.31004185
46MAP3K101.29649409
47LATS11.25331906
48VRK21.24719674
49DYRK31.22799732
50ALK1.18079601
51ZAK1.13724128
52SCYL21.06242863
53NME21.04726680
54CDK21.04387089
55NEK10.96333690
56ACVR1B0.95138522
57TGFBR10.92495184
58MELK0.88519075
59PKN20.88022062
60PBK0.87732874
61STK160.86999475
62MTOR0.85869182
63CDK10.84266984
64SIK30.83223989
65EIF2AK20.83064444
66CDK90.82168774
67PIM10.80610454
68AURKA0.79107035
69STK390.78011209
70VRK10.77291187
71FGFR10.77145806
72CSNK2A20.74429521
73NME10.72896412
74STK38L0.72356599
75MAP3K40.72071625
76CSNK1E0.70108977
77CLK10.69510172
78MST40.68931936
79OXSR10.67220576
80PAK20.64774551
81MAP4K10.62876250
82CCNB10.62715362
83PRKDC0.61860137
84GRK10.61458013
85CSNK1D0.61331696
86RPS6KA50.60029939
87CSNK2A10.59013221
88TTN0.58186036
89ERBB40.53077432
90CHUK0.50415671
91MAPK140.50155284
92MARK30.49615789
93LRRK20.49553970
94CAMK1D0.48731186
95CDK80.47556959
96PAK40.47477373
97CSNK1G30.46707452
98PDK20.45719071
99TEC0.45116683
100FGFR20.44980893
101FLT30.44681684
102MAPK130.44525785
103CDK30.43151007
104JAK30.42666271
105ERBB30.42064686
106CSNK1G20.41885455
107AKT30.39408637
108YES10.38735924
109AKT20.37397840
110AKT10.37320757
111CSNK1A1L0.37250147
112BTK0.37065948
113NLK0.36666472
114STK240.36478259
115BRSK10.36093965
116PAK10.35511753
117TXK0.33978528
118MAPK10.33005089
119TESK20.32824777
120BCR0.32615358
121GSK3B0.32436537
122BRAF0.31916548
123MAP2K30.31861208
124PRKCI0.30900822
125MAP3K50.30681049
126PAK30.30527513
127KSR10.30137703
128RPS6KB10.29188786
129EPHB20.28938069
130INSRR0.26803217
131WNK40.26491363
132MAPKAPK20.26051209
133MINK10.26003337
134CSNK1G10.25881529
135TAOK20.25602923
136PRKCE0.24531418
137FER0.21583110
138TRPM70.17273198

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94105012
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77019871
3Mismatch repair_Homo sapiens_hsa034303.53313524
4Spliceosome_Homo sapiens_hsa030403.45746749
5RNA transport_Homo sapiens_hsa030133.30489109
6Cell cycle_Homo sapiens_hsa041102.78954074
7One carbon pool by folate_Homo sapiens_hsa006702.72454740
8Homologous recombination_Homo sapiens_hsa034402.66160394
9Protein export_Homo sapiens_hsa030602.62956605
10mRNA surveillance pathway_Homo sapiens_hsa030152.52627589
11Nucleotide excision repair_Homo sapiens_hsa034202.50714291
12Fanconi anemia pathway_Homo sapiens_hsa034602.48946156
13Ribosome_Homo sapiens_hsa030102.48804134
14Base excision repair_Homo sapiens_hsa034102.47075389
15RNA polymerase_Homo sapiens_hsa030202.27876459
16RNA degradation_Homo sapiens_hsa030182.20995105
17Non-homologous end-joining_Homo sapiens_hsa034502.12910503
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10597473
19Propanoate metabolism_Homo sapiens_hsa006401.99947907
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90469844
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.80575527
22Steroid biosynthesis_Homo sapiens_hsa001001.76645441
23Basal transcription factors_Homo sapiens_hsa030221.75858758
24Pyrimidine metabolism_Homo sapiens_hsa002401.68018316
25p53 signaling pathway_Homo sapiens_hsa041151.65904243
26Proteasome_Homo sapiens_hsa030501.64042788
27Vitamin B6 metabolism_Homo sapiens_hsa007501.62449747
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53527815
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44799066
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36943523
31MicroRNAs in cancer_Homo sapiens_hsa052061.36683580
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35569488
33Pyruvate metabolism_Homo sapiens_hsa006201.33149336
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32576974
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31132582
36Systemic lupus erythematosus_Homo sapiens_hsa053221.23902506
37Epstein-Barr virus infection_Homo sapiens_hsa051691.20457209
38Viral carcinogenesis_Homo sapiens_hsa052031.20303283
39Antigen processing and presentation_Homo sapiens_hsa046121.16364721
40Herpes simplex infection_Homo sapiens_hsa051681.16162791
41HTLV-I infection_Homo sapiens_hsa051661.11043847
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11019373
43Basal cell carcinoma_Homo sapiens_hsa052171.10437059
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10019519
45Small cell lung cancer_Homo sapiens_hsa052221.02944488
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02611448
47Oocyte meiosis_Homo sapiens_hsa041141.01729779
48TGF-beta signaling pathway_Homo sapiens_hsa043500.95339530
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94908922
50Thyroid cancer_Homo sapiens_hsa052160.94577007
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94391299
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94288123
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93644442
54Hippo signaling pathway_Homo sapiens_hsa043900.89782239
55Adherens junction_Homo sapiens_hsa045200.87118194
56Biosynthesis of amino acids_Homo sapiens_hsa012300.87048422
57Carbon metabolism_Homo sapiens_hsa012000.85971304
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85229389
59Viral myocarditis_Homo sapiens_hsa054160.84679128
60Chronic myeloid leukemia_Homo sapiens_hsa052200.82051416
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.81386650
62Purine metabolism_Homo sapiens_hsa002300.81293536
63Fatty acid elongation_Homo sapiens_hsa000620.78758510
64Phototransduction_Homo sapiens_hsa047440.78143936
65Parkinsons disease_Homo sapiens_hsa050120.77760170
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77417216
67Notch signaling pathway_Homo sapiens_hsa043300.76506397
68Butanoate metabolism_Homo sapiens_hsa006500.75976883
69Hedgehog signaling pathway_Homo sapiens_hsa043400.73827864
70Huntingtons disease_Homo sapiens_hsa050160.73578108
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73160054
72Wnt signaling pathway_Homo sapiens_hsa043100.71973947
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71536159
74Primary immunodeficiency_Homo sapiens_hsa053400.70588587
75Hepatitis B_Homo sapiens_hsa051610.69550595
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69252149
77Prostate cancer_Homo sapiens_hsa052150.67657833
78Oxidative phosphorylation_Homo sapiens_hsa001900.67627785
79Measles_Homo sapiens_hsa051620.65494620
80Colorectal cancer_Homo sapiens_hsa052100.63654717
81Legionellosis_Homo sapiens_hsa051340.62217377
82Lysine degradation_Homo sapiens_hsa003100.61966130
83Glutathione metabolism_Homo sapiens_hsa004800.61919693
84Pathways in cancer_Homo sapiens_hsa052000.60848642
85Proteoglycans in cancer_Homo sapiens_hsa052050.58098861
86Sulfur metabolism_Homo sapiens_hsa009200.57231564
87Folate biosynthesis_Homo sapiens_hsa007900.55778637
88Hematopoietic cell lineage_Homo sapiens_hsa046400.53599610
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52584215
90Metabolic pathways_Homo sapiens_hsa011000.52133774
91Shigellosis_Homo sapiens_hsa051310.51199541
92Apoptosis_Homo sapiens_hsa042100.51105724
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51012371
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50811634
95T cell receptor signaling pathway_Homo sapiens_hsa046600.48931586
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47265487
97Fatty acid metabolism_Homo sapiens_hsa012120.45743350
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45204151
99N-Glycan biosynthesis_Homo sapiens_hsa005100.44483018
100Alcoholism_Homo sapiens_hsa050340.44475796
101Acute myeloid leukemia_Homo sapiens_hsa052210.43934857
102Bladder cancer_Homo sapiens_hsa052190.43778545
103Tight junction_Homo sapiens_hsa045300.43615559
104HIF-1 signaling pathway_Homo sapiens_hsa040660.42205843
105ECM-receptor interaction_Homo sapiens_hsa045120.42186079
106Influenza A_Homo sapiens_hsa051640.41692924
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.41664293
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.41591242
109Asthma_Homo sapiens_hsa053100.40636030
110beta-Alanine metabolism_Homo sapiens_hsa004100.39094209
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38475310
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38159214
113B cell receptor signaling pathway_Homo sapiens_hsa046620.37402515
114FoxO signaling pathway_Homo sapiens_hsa040680.36887745
115Melanoma_Homo sapiens_hsa052180.36757176
116Non-small cell lung cancer_Homo sapiens_hsa052230.36721082
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.36515784
118Peroxisome_Homo sapiens_hsa041460.35266605
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35217413
120Pancreatic cancer_Homo sapiens_hsa052120.35101357
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34684332
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.34249120
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34067769
124Selenocompound metabolism_Homo sapiens_hsa004500.33919051
125Renal cell carcinoma_Homo sapiens_hsa052110.32936468
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32839592
127Allograft rejection_Homo sapiens_hsa053300.32513784
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31686902
129Tryptophan metabolism_Homo sapiens_hsa003800.31423735
130Graft-versus-host disease_Homo sapiens_hsa053320.31288784
131Focal adhesion_Homo sapiens_hsa045100.31035850
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30962038
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30709166
134Arginine and proline metabolism_Homo sapiens_hsa003300.30664494
135Nitrogen metabolism_Homo sapiens_hsa009100.30421218
136mTOR signaling pathway_Homo sapiens_hsa041500.29918382
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29219842
138Leishmaniasis_Homo sapiens_hsa051400.28813963
139Toxoplasmosis_Homo sapiens_hsa051450.28321523
140Olfactory transduction_Homo sapiens_hsa047400.27411678
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26769439
142Alzheimers disease_Homo sapiens_hsa050100.26765294
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25878775
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25588243
145Dorso-ventral axis formation_Homo sapiens_hsa043200.23881331
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.23544822
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23359797
148Vitamin digestion and absorption_Homo sapiens_hsa049770.21216390
149Circadian rhythm_Homo sapiens_hsa047100.21007030
150Ether lipid metabolism_Homo sapiens_hsa005650.20883962
151Fatty acid degradation_Homo sapiens_hsa000710.18416001
152Caffeine metabolism_Homo sapiens_hsa002320.17594252
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13111364
154Retinol metabolism_Homo sapiens_hsa008300.10082716

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