NAA20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23261508
2cellular ketone body metabolic process (GO:0046950)5.10777880
3proteasome assembly (GO:0043248)4.86991603
4ATP synthesis coupled proton transport (GO:0015986)4.83659500
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.83659500
6ketone body metabolic process (GO:1902224)4.63868824
7cullin deneddylation (GO:0010388)4.37371269
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33603697
9inositol phosphate catabolic process (GO:0071545)4.32748416
10water-soluble vitamin biosynthetic process (GO:0042364)4.26774367
11negative regulation of execution phase of apoptosis (GO:1900118)4.22226884
12protein neddylation (GO:0045116)4.22036923
13protein deneddylation (GO:0000338)4.21911628
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.16305879
15positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.15700361
16inositol phosphate dephosphorylation (GO:0046855)4.11837299
17phosphorylated carbohydrate dephosphorylation (GO:0046838)4.11837299
18protein complex biogenesis (GO:0070271)4.10934988
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10313426
20pteridine-containing compound biosynthetic process (GO:0042559)4.09977703
21chaperone-mediated protein transport (GO:0072321)4.03337508
22antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.00178816
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.99917969
24NADH dehydrogenase complex assembly (GO:0010257)3.99917969
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99917969
26respiratory electron transport chain (GO:0022904)3.98544339
27DNA deamination (GO:0045006)3.97534963
28electron transport chain (GO:0022900)3.89071163
29regulation of cellular amino acid metabolic process (GO:0006521)3.87866620
30positive regulation of histone H3-K4 methylation (GO:0051571)3.84799708
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84511713
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81788625
33mitochondrial respiratory chain complex assembly (GO:0033108)3.79214847
34regulation of type B pancreatic cell apoptotic process (GO:2000674)3.78991657
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.76848407
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.76848407
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75236373
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75236373
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75236373
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71853120
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67794842
42lactate metabolic process (GO:0006089)3.66931964
43negative regulation of ligase activity (GO:0051352)3.66094242
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66094242
45ribosomal small subunit assembly (GO:0000028)3.62182945
46regulation of mitochondrial translation (GO:0070129)3.61621204
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.61230075
48signal transduction involved in DNA damage checkpoint (GO:0072422)3.61230075
49epithelial cell fate commitment (GO:0072148)3.55416655
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.55333738
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55293159
52L-phenylalanine metabolic process (GO:0006558)3.55293159
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52052903
54termination of RNA polymerase III transcription (GO:0006386)3.51211374
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.51211374
562-deoxyribonucleotide biosynthetic process (GO:0009265)3.47183166
57deoxyribose phosphate biosynthetic process (GO:0046385)3.47183166
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.46273620
59cytochrome complex assembly (GO:0017004)3.46171804
607-methylguanosine mRNA capping (GO:0006370)3.45242560
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43551355
62polyol catabolic process (GO:0046174)3.43481025
63RNA capping (GO:0036260)3.43114568
647-methylguanosine RNA capping (GO:0009452)3.43114568
65antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.34619106
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34473375
67L-phenylalanine catabolic process (GO:0006559)3.34473375
68signal peptide processing (GO:0006465)3.33542468
69regulation of hexokinase activity (GO:1903299)3.30370223
70regulation of glucokinase activity (GO:0033131)3.30370223
71respiratory chain complex IV assembly (GO:0008535)3.27715405
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27602579
73deoxyribonucleotide biosynthetic process (GO:0009263)3.22889417
74oxidative phosphorylation (GO:0006119)3.22805412
75rRNA modification (GO:0000154)3.22766693
76C-terminal protein lipidation (GO:0006501)3.22442950
77insulin secretion (GO:0030073)3.21004826
78protein targeting to mitochondrion (GO:0006626)3.17020320
79positive regulation of ligase activity (GO:0051351)3.16241441
80L-alpha-amino acid transmembrane transport (GO:1902475)3.11092900
81establishment of protein localization to mitochondrion (GO:0072655)3.10363309
82peptide hormone processing (GO:0016486)3.09013587
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08549615
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08549615
85glucosamine-containing compound catabolic process (GO:1901072)3.07615265
86nucleobase-containing small molecule interconversion (GO:0015949)3.07303419
87nitric oxide biosynthetic process (GO:0006809)3.04870419
88platelet dense granule organization (GO:0060155)3.03901017
89endocrine pancreas development (GO:0031018)3.01718063
90GTP biosynthetic process (GO:0006183)3.01646935
91branched-chain amino acid catabolic process (GO:0009083)3.01381811
92positive regulation of insulin secretion (GO:0032024)3.00693208
93glycerophospholipid catabolic process (GO:0046475)2.99797625
94establishment of viral latency (GO:0019043)2.97568065
95guanosine-containing compound biosynthetic process (GO:1901070)2.96608711
96telomere maintenance via semi-conservative replication (GO:0032201)2.95655373
97iron-sulfur cluster assembly (GO:0016226)2.95197526
98metallo-sulfur cluster assembly (GO:0031163)2.95197526
99peptidyl-histidine modification (GO:0018202)2.93610879
100positive regulation of cell cycle arrest (GO:0071158)2.93242138
101mannosylation (GO:0097502)2.92750322
102retinol metabolic process (GO:0042572)2.91282762
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90898739
104protein-cofactor linkage (GO:0018065)2.90137205
105DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.89376213
106deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.88775289
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88322873
108xenobiotic catabolic process (GO:0042178)2.87844981
109regulation of cellular amine metabolic process (GO:0033238)2.87377238
110establishment of integrated proviral latency (GO:0075713)2.87181983
111protein localization to mitochondrion (GO:0070585)2.85313331
112translation (GO:0006412)2.84876407
113C-terminal protein amino acid modification (GO:0018410)2.84710861
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84499872
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83009369
116cotranslational protein targeting to membrane (GO:0006613)2.81215013
117preassembly of GPI anchor in ER membrane (GO:0016254)2.80867402
118ATP hydrolysis coupled proton transport (GO:0015991)2.78459587
119energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78459587
120maturation of SSU-rRNA (GO:0030490)2.78435421
121telomere maintenance via recombination (GO:0000722)2.76979417
122spliceosomal snRNP assembly (GO:0000387)2.76413628
123regulation of ubiquitin-protein transferase activity (GO:0051438)2.76172088
124auditory receptor cell differentiation (GO:0042491)2.75996465
125cell cycle G1/S phase transition (GO:0044843)2.75592833
126G1/S transition of mitotic cell cycle (GO:0000082)2.75592833
127protein targeting to ER (GO:0045047)2.75558470
128positive regulation of gluconeogenesis (GO:0045722)2.73665847
129ribosomal small subunit biogenesis (GO:0042274)2.73617188
130de novo protein folding (GO:0006458)2.71883542
131transcription-coupled nucleotide-excision repair (GO:0006283)2.71395904
132cellular component biogenesis (GO:0044085)2.71365646
133rRNA methylation (GO:0031167)2.70854840
134regulation of execution phase of apoptosis (GO:1900117)2.69955572
135pseudouridine synthesis (GO:0001522)2.69259965
136S-adenosylmethionine metabolic process (GO:0046500)2.69002911
137regulation of ligase activity (GO:0051340)2.68951806
138axoneme assembly (GO:0035082)2.68095704
139cellular response to interferon-beta (GO:0035458)2.67899849
140de novo posttranslational protein folding (GO:0051084)2.66968186
141protein localization to endoplasmic reticulum (GO:0070972)2.66950136
142magnesium ion transport (GO:0015693)2.64858122
143keratinocyte development (GO:0003334)2.64267197
144prenylation (GO:0097354)2.62869687
145protein prenylation (GO:0018342)2.62869687
146positive regulation of calcium ion import (GO:0090280)2.61287349
147regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.60578103
148detection of calcium ion (GO:0005513)2.60160653
149protein maturation by protein folding (GO:0022417)2.59636357
150positive regulation of actin filament depolymerization (GO:0030836)2.58344519
151hydrogen ion transmembrane transport (GO:1902600)2.57005164
152positive regulation of peptide hormone secretion (GO:0090277)2.56260274
153aromatic amino acid family catabolic process (GO:0009074)2.54193697
154regulation of cilium movement (GO:0003352)2.53271105
155zinc ion transport (GO:0006829)2.49315164
156proton transport (GO:0015992)2.49240986
157phenylpropanoid metabolic process (GO:0009698)2.48552537
158dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.48493896
159hydrogen transport (GO:0006818)2.46210294
160glandular epithelial cell differentiation (GO:0002067)2.44449897
161L-methionine salvage (GO:0071267)2.43971227
162L-methionine biosynthetic process (GO:0071265)2.43971227
163amino acid salvage (GO:0043102)2.43971227
164positive regulation of peptide secretion (GO:0002793)2.43453311
165GPI anchor biosynthetic process (GO:0006506)2.42639492
166nodal signaling pathway (GO:0038092)2.42436167
167glutathione derivative biosynthetic process (GO:1901687)2.42360202
168glutathione derivative metabolic process (GO:1901685)2.42360202
169zinc ion transmembrane transport (GO:0071577)2.41481071
170aldehyde catabolic process (GO:0046185)2.40390796
171protein autoprocessing (GO:0016540)2.40238635
172regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.39227753
173regulation of oxidative phosphorylation (GO:0002082)2.39065482
174regulation of acyl-CoA biosynthetic process (GO:0050812)2.38118504
175GPI anchor metabolic process (GO:0006505)2.36109276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.36370635
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05181649
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.44344294
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.03101936
5E2F7_22180533_ChIP-Seq_HELA_Human4.02497726
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84780222
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.65299576
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.47936551
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.25023738
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21489036
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08311372
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05432228
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99723720
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99018596
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80684324
16VDR_23849224_ChIP-Seq_CD4+_Human2.75820901
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60061755
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59192815
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57860052
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.57687622
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54484249
22ELK1_19687146_ChIP-ChIP_HELA_Human2.51163259
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35546555
24ZNF274_21170338_ChIP-Seq_K562_Hela2.26600646
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25713420
26DCP1A_22483619_ChIP-Seq_HELA_Human2.23082850
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17105347
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16174975
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15328349
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15293660
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14177593
32GBX2_23144817_ChIP-Seq_PC3_Human2.12656766
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07216973
34FOXP3_21729870_ChIP-Seq_TREG_Human1.98270150
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.96290408
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95843550
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92849641
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90241246
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89655547
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.89227461
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86728271
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86650719
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.85348107
44HTT_18923047_ChIP-ChIP_STHdh_Human1.81733867
45GABP_19822575_ChIP-Seq_HepG2_Human1.79060054
46XRN2_22483619_ChIP-Seq_HELA_Human1.76899501
47TTF2_22483619_ChIP-Seq_HELA_Human1.73835819
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70057588
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.69297138
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66693610
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65622623
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62896952
53P300_19829295_ChIP-Seq_ESCs_Human1.50960332
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49630917
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46137648
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.46042727
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45407149
58* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40773657
59ER_23166858_ChIP-Seq_MCF-7_Human1.40668625
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39551631
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.39277311
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39277311
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38784249
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37982448
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.37139965
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36832194
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35477587
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.33881450
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32947574
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32914899
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31558584
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30817381
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.29254312
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.29170295
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27064683
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26616458
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.24899895
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24566575
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24504826
80SMAD4_21799915_ChIP-Seq_A2780_Human1.23447583
81AR_20517297_ChIP-Seq_VCAP_Human1.22102113
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21074142
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20938898
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.20392772
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.20212954
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19978281
87SOX2_19829295_ChIP-Seq_ESCs_Human1.19669408
88NANOG_19829295_ChIP-Seq_ESCs_Human1.19669408
89MYC_18940864_ChIP-ChIP_HL60_Human1.19032268
90BCAT_22108803_ChIP-Seq_LS180_Human1.18452293
91* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18123916
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18052547
93* STAT3_18555785_Chip-Seq_ESCs_Mouse1.17901092
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16716679
95AR_25329375_ChIP-Seq_VCAP_Human1.15902578
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15315973
97VDR_22108803_ChIP-Seq_LS180_Human1.13805548
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13781603
99SPI1_23547873_ChIP-Seq_NB4_Human1.13497583
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.11764024
101CDX2_22108803_ChIP-Seq_LS180_Human1.11449289
102* SOX2_18555785_Chip-Seq_ESCs_Mouse1.11401434
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11270271
104* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10802679
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.10358029
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09062224
107* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08827680
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07623605
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07373127
110TCF4_22108803_ChIP-Seq_LS180_Human1.07014540
111P300_18555785_Chip-Seq_ESCs_Mouse1.06947484
112FUS_26573619_Chip-Seq_HEK293_Human1.06891897
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06835128
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06177286
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05986079
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.05498254
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04818491
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03218932
119* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03016682
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02190524
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02190418
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01671477
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00510134
124* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00409228
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00240555
126* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99924774
127CBP_20019798_ChIP-Seq_JUKART_Human0.99916185
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99916185
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99913796
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99620969
131E2F1_21310950_ChIP-Seq_MCF-7_Human0.99543775
132* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99292719
133* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98896279
134CTCF_18555785_Chip-Seq_ESCs_Mouse0.97869198
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97617614
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97165561
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96944365
138NCOR_22424771_ChIP-Seq_293T_Human0.96608899
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95531441
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95209260
141* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95029881
142ZFX_18555785_Chip-Seq_ESCs_Mouse0.94657292
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93945888
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93479291
145PHF8_20622853_ChIP-Seq_HELA_Human0.93246870
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93131923
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88879507
148TAF15_26573619_Chip-Seq_HEK293_Human0.88026596
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88010874
150IRF1_19129219_ChIP-ChIP_H3396_Human0.87376474
151TFEB_21752829_ChIP-Seq_HELA_Human0.87232236
152EWS_26573619_Chip-Seq_HEK293_Human0.85274406
153IGF1R_20145208_ChIP-Seq_DFB_Human0.84203556
154FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82138297
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80650116
156SOX17_20123909_ChIP-Seq_XEN_Mouse0.77008138
157CIITA_25753668_ChIP-Seq_RAJI_Human0.72554534
158IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68902427
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65988844
160AR_21909140_ChIP-Seq_LNCAP_Human0.64247040
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.63077542
162TP53_22573176_ChIP-Seq_HFKS_Human0.62824552
163CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62630229
164EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62260318
165CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61762647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.95795688
2MP0010234_abnormal_vibrissa_follicle3.35353218
3MP0002139_abnormal_hepatobiliary_system3.08278760
4MP0002909_abnormal_adrenal_gland3.05884882
5MP0003195_calcinosis2.81208008
6MP0006072_abnormal_retinal_apoptosis2.74458834
7MP0001835_abnormal_antigen_presentation2.58217565
8MP0003693_abnormal_embryo_hatching2.55193988
9MP0009785_altered_susceptibility_to2.43677662
10MP0005084_abnormal_gallbladder_morpholo2.43103933
11MP0001944_abnormal_pancreas_morphology2.35836410
12MP0003880_abnormal_central_pattern2.31948211
13MP0002148_abnormal_hypersensitivity_rea2.31775485
14MP0000013_abnormal_adipose_tissue2.26835158
15MP0001986_abnormal_taste_sensitivity2.25878061
16MP0001188_hyperpigmentation2.20885194
17MP0008058_abnormal_DNA_repair2.19561221
18MP0001529_abnormal_vocalization2.13896439
19MP0004957_abnormal_blastocyst_morpholog2.12789022
20MP0005671_abnormal_response_to2.11904694
21MP0010386_abnormal_urinary_bladder2.07370505
22MP0008057_abnormal_DNA_replication2.03743106
23MP0000372_irregular_coat_pigmentation2.02035195
24MP0009379_abnormal_foot_pigmentation2.01878054
25MP0002876_abnormal_thyroid_physiology2.00309538
26MP0005332_abnormal_amino_acid1.98031150
27MP0010094_abnormal_chromosome_stability1.93370839
28MP0003724_increased_susceptibility_to1.90245432
29MP0002638_abnormal_pupillary_reflex1.88794293
30MP0003806_abnormal_nucleotide_metabolis1.86743719
31MP0003787_abnormal_imprinting1.86108065
32MP0002163_abnormal_gland_morphology1.83498005
33MP0004019_abnormal_vitamin_homeostasis1.83489446
34MP0002254_reproductive_system_inflammat1.82218990
35MP0001905_abnormal_dopamine_level1.81821977
36MP0006036_abnormal_mitochondrial_physio1.81200159
37MP0003011_delayed_dark_adaptation1.80757732
38MP0005171_absent_coat_pigmentation1.78217598
39MP0009697_abnormal_copulation1.71677468
40MP0005379_endocrine/exocrine_gland_phen1.71117454
41MP0001984_abnormal_olfaction1.69445422
42MP0009333_abnormal_splenocyte_physiolog1.64521612
43MP0008877_abnormal_DNA_methylation1.63589052
44MP0008007_abnormal_cellular_replicative1.60633140
45MP0001756_abnormal_urination1.60149069
46MP0006292_abnormal_olfactory_placode1.59476846
47MP0005000_abnormal_immune_tolerance1.58165553
48MP0008932_abnormal_embryonic_tissue1.56683053
49MP0005365_abnormal_bile_salt1.56500829
50MP0002736_abnormal_nociception_after1.55759514
51MP0003186_abnormal_redox_activity1.53771353
52MP0000015_abnormal_ear_pigmentation1.53552027
53MP0005551_abnormal_eye_electrophysiolog1.52368323
54MP0003077_abnormal_cell_cycle1.49486673
55MP0005253_abnormal_eye_physiology1.47169224
56MP0010329_abnormal_lipoprotein_level1.46830980
57MP0005636_abnormal_mineral_homeostasis1.46433296
58MP0005220_abnormal_exocrine_pancreas1.45861314
59MP0003786_premature_aging1.44178693
60MP0002078_abnormal_glucose_homeostasis1.39368696
61MP0000427_abnormal_hair_cycle1.38483134
62MP0006035_abnormal_mitochondrial_morpho1.38084553
63MP0008875_abnormal_xenobiotic_pharmacok1.35004196
64MP0003646_muscle_fatigue1.34613353
65MP0005025_abnormal_response_to1.34594394
66MP0006082_CNS_inflammation1.32043301
67MP0006276_abnormal_autonomic_nervous1.31867730
68MP0001542_abnormal_bone_strength1.31652672
69MP0002090_abnormal_vision1.28565859
70MP0003718_maternal_effect1.27466233
71MP0004270_analgesia1.24801637
72MP0000681_abnormal_thyroid_gland1.21821649
73MP0002723_abnormal_immune_serum1.21782891
74MP0001853_heart_inflammation1.21529477
75MP0010678_abnormal_skin_adnexa1.18060564
76MP0002419_abnormal_innate_immunity1.17420754
77MP0001661_extended_life_span1.16833351
78MP0002160_abnormal_reproductive_system1.16160262
79MP0005408_hypopigmentation1.16138583
80MP0002420_abnormal_adaptive_immunity1.16033982
81MP0001819_abnormal_immune_cell1.16032251
82MP0003111_abnormal_nucleus_morphology1.15827444
83MP0000516_abnormal_urinary_system1.15475047
84MP0005367_renal/urinary_system_phenotyp1.15475047
85MP0002735_abnormal_chemical_nociception1.15355475
86MP0002452_abnormal_antigen_presenting1.15290565
87MP0001501_abnormal_sleep_pattern1.12001430
88MP0001968_abnormal_touch/_nociception1.08907178
89MP0000639_abnormal_adrenal_gland1.08678181
90MP0003122_maternal_imprinting1.07987774
91MP0004133_heterotaxia1.07188802
92MP0009046_muscle_twitch1.07002310
93MP0002095_abnormal_skin_pigmentation1.06632181
94MP0000631_abnormal_neuroendocrine_gland1.06362275
95MP0004142_abnormal_muscle_tone1.06229027
96MP0003763_abnormal_thymus_physiology1.04934172
97MP0003123_paternal_imprinting1.04390930
98MP0002277_abnormal_respiratory_mucosa1.03319551
99MP0003136_yellow_coat_color1.02853841
100MP0001800_abnormal_humoral_immune1.02486884
101MP0005248_abnormal_Harderian_gland1.01259041
102MP0002693_abnormal_pancreas_physiology0.98628482
103MP0001765_abnormal_ion_homeostasis0.98271749
104MP0003953_abnormal_hormone_level0.97810855
105MP0005646_abnormal_pituitary_gland0.97310669
106MP0005389_reproductive_system_phenotype0.95928534
107MP0001764_abnormal_homeostasis0.95797908
108MP0002928_abnormal_bile_duct0.95228964
109MP0003436_decreased_susceptibility_to0.94912708
110MP0005085_abnormal_gallbladder_physiolo0.94420799
111MP0002398_abnormal_bone_marrow0.94168272
112MP0008872_abnormal_physiological_respon0.92501084
113MP0008260_abnormal_autophagy0.92391503
114MP0004782_abnormal_surfactant_physiolog0.89831830
115MP0000749_muscle_degeneration0.89579637
116MP0002396_abnormal_hematopoietic_system0.89272039
117MP0005174_abnormal_tail_pigmentation0.88991968
118MP0005448_abnormal_energy_balance0.88619571
119MP0003121_genomic_imprinting0.87206427
120MP0000343_altered_response_to0.86674940
121MP0006054_spinal_hemorrhage0.86250372
122MP0005645_abnormal_hypothalamus_physiol0.86166747
123MP0004215_abnormal_myocardial_fiber0.84902488
124MP0005075_abnormal_melanosome_morpholog0.83927642
125MP0000685_abnormal_immune_system0.83841315
126MP0000716_abnormal_immune_system0.83046164
127MP0002837_dystrophic_cardiac_calcinosis0.82830327
128MP0009745_abnormal_behavioral_response0.81908409
129MP0003879_abnormal_hair_cell0.81712832
130MP0005535_abnormal_body_temperature0.81280826
131MP0004147_increased_porphyrin_level0.81154547
132MP0002064_seizures0.81085517
133MP0002734_abnormal_mechanical_nocicepti0.80807562
134MP0000358_abnormal_cell_content/0.80423901
135MP0000858_altered_metastatic_potential0.80110092
136MP0005387_immune_system_phenotype0.79506286
137MP0001790_abnormal_immune_system0.79506286
138MP0002272_abnormal_nervous_system0.79372197
139MP0003183_abnormal_peptide_metabolism0.78851541
140MP0002332_abnormal_exercise_endurance0.78028203
141MP0000490_abnormal_crypts_of0.77798058
142MP0000689_abnormal_spleen_morphology0.77725766
143MP0005310_abnormal_salivary_gland0.77518374
144MP0004885_abnormal_endolymph0.77031832
145MP0002429_abnormal_blood_cell0.76354856
146MP0000538_abnormal_urinary_bladder0.76250534
147MP0003252_abnormal_bile_duct0.75302652
148MP0004043_abnormal_pH_regulation0.74759079
149MP0009643_abnormal_urine_homeostasis0.74606090
150MP0003172_abnormal_lysosome_physiology0.74121579
151MP0005410_abnormal_fertilization0.73941519
152MP0002938_white_spotting0.73777517
153MP0002118_abnormal_lipid_homeostasis0.73654401
154MP0002166_altered_tumor_susceptibility0.72197451
155MP0000003_abnormal_adipose_tissue0.71364043
156MP0008004_abnormal_stomach_pH0.71071333
157MP0002229_neurodegeneration0.70426405
158MP0002557_abnormal_social/conspecific_i0.70090015
159MP0005386_behavior/neurological_phenoty0.67959563
160MP0004924_abnormal_behavior0.67959563
161MP0001970_abnormal_pain_threshold0.67368413

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.07228639
2Abnormal mitochondria in muscle tissue (HP:0008316)5.61804316
3Mitochondrial inheritance (HP:0001427)5.32512573
4Progressive macrocephaly (HP:0004481)5.01196347
5Increased CSF lactate (HP:0002490)4.70121363
6Hepatocellular necrosis (HP:0001404)4.51624383
7Acute encephalopathy (HP:0006846)4.49873154
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.36156502
9Hepatic necrosis (HP:0002605)3.87086133
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74395775
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74395775
12Increased hepatocellular lipid droplets (HP:0006565)3.66415478
13Exercise intolerance (HP:0003546)3.43817720
143-Methylglutaconic aciduria (HP:0003535)3.35260436
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35150182
16Hypoglycemic coma (HP:0001325)3.34025929
17Increased serum lactate (HP:0002151)3.33210355
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.28980431
19Ketoacidosis (HP:0001993)3.26081457
20Abnormality of vitamin B metabolism (HP:0004340)3.22235250
21Increased serum pyruvate (HP:0003542)3.21149639
22Abnormality of glycolysis (HP:0004366)3.21149639
23Hyperglycemia (HP:0003074)3.16405724
24Type I transferrin isoform profile (HP:0003642)3.15917031
25Birth length less than 3rd percentile (HP:0003561)3.12040704
26Double outlet right ventricle (HP:0001719)3.11873500
27Congenital malformation of the right heart (HP:0011723)3.11873500
28Lipid accumulation in hepatocytes (HP:0006561)3.10393907
29Lactic acidosis (HP:0003128)3.07683785
30Methylmalonic acidemia (HP:0002912)3.07012992
31Optic disc pallor (HP:0000543)3.06348630
32Respiratory failure (HP:0002878)3.05954669
33Large for gestational age (HP:0001520)2.99104988
34Exertional dyspnea (HP:0002875)2.96449115
35Hypothermia (HP:0002045)2.96111771
36Hyperinsulinemic hypoglycemia (HP:0000825)2.94662673
37Intestinal atresia (HP:0011100)2.81301509
38Renal Fanconi syndrome (HP:0001994)2.78572347
39Conjunctival hamartoma (HP:0100780)2.78205105
40Hypoglycemic seizures (HP:0002173)2.73935830
41Glycosuria (HP:0003076)2.73025659
42Abnormality of urine glucose concentration (HP:0011016)2.73025659
43Increased intramyocellular lipid droplets (HP:0012240)2.69596695
44Abnormality of vitamin metabolism (HP:0100508)2.66333917
45Abnormal number of erythroid precursors (HP:0012131)2.64573633
46Abnormality of cells of the erythroid lineage (HP:0012130)2.59392897
47Cerebral edema (HP:0002181)2.59307988
48Methylmalonic aciduria (HP:0012120)2.55683511
49Abnormal hair whorl (HP:0010721)2.54537617
50Leukodystrophy (HP:0002415)2.51815216
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46441278
52Abnormality of alanine metabolism (HP:0010916)2.46441278
53Hyperalaninemia (HP:0003348)2.46441278
54Ketosis (HP:0001946)2.44387226
55Aplastic anemia (HP:0001915)2.44279512
56Medial flaring of the eyebrow (HP:0010747)2.42912512
57Tongue fasciculations (HP:0001308)2.42092228
58Poor head control (HP:0002421)2.41229401
59Increased CSF protein (HP:0002922)2.41151395
60Hemiparesis (HP:0001269)2.39060230
61Microvesicular hepatic steatosis (HP:0001414)2.38656227
62Respiratory difficulties (HP:0002880)2.38478523
63Abnormality of midbrain morphology (HP:0002418)2.36405859
64Molar tooth sign on MRI (HP:0002419)2.36405859
65Nephrogenic diabetes insipidus (HP:0009806)2.34724699
66Reticulocytopenia (HP:0001896)2.30479485
67Abnormal protein glycosylation (HP:0012346)2.30264348
68Abnormal glycosylation (HP:0012345)2.30264348
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30264348
70Abnormal protein N-linked glycosylation (HP:0012347)2.30264348
71True hermaphroditism (HP:0010459)2.28257539
72Neuroendocrine neoplasm (HP:0100634)2.27679789
73Neoplasm of the adrenal gland (HP:0100631)2.26750365
74Lethargy (HP:0001254)2.26480638
75Congenital primary aphakia (HP:0007707)2.25767263
76Vascular calcification (HP:0004934)2.22468020
77Hypokinesia (HP:0002375)2.22120217
78Abnormality of the renal cortex (HP:0011035)2.21109092
79Furrowed tongue (HP:0000221)2.20090162
80Pancreatic fibrosis (HP:0100732)2.19698351
81Premature graying of hair (HP:0002216)2.19596707
82Rough bone trabeculation (HP:0100670)2.19062742
83Type 2 muscle fiber atrophy (HP:0003554)2.18788371
84Nephronophthisis (HP:0000090)2.18112324
85Hamartoma of the eye (HP:0010568)2.17642181
86Agnosia (HP:0010524)2.16304714
87Gait imbalance (HP:0002141)2.14575101
88Increased IgM level (HP:0003496)2.13697710
89Muscular hypotonia of the trunk (HP:0008936)2.13361706
90Cerebral hypomyelination (HP:0006808)2.12710173
91Palpitations (HP:0001962)2.12438245
92Congenital sensorineural hearing impairment (HP:0008527)2.12162325
93Generalized aminoaciduria (HP:0002909)2.10948894
94Recurrent abscess formation (HP:0002722)2.09328971
95Elevated erythrocyte sedimentation rate (HP:0003565)2.08156370
96Increased muscle lipid content (HP:0009058)2.07447550
97Renal cortical cysts (HP:0000803)2.05570995
98Hypoalbuminemia (HP:0003073)2.03333183
99Abnormal albumin level (HP:0012116)2.03333183
100Symptomatic seizures (HP:0011145)2.02724079
101Enlarged penis (HP:0000040)2.02665840
102Unsteady gait (HP:0002317)2.02353242
103Pancreatic cysts (HP:0001737)2.00143233
104Orthostatic hypotension (HP:0001278)1.98224784
105Abnormal rod and cone electroretinograms (HP:0008323)1.97389153
106Pallor (HP:0000980)1.97380831
107Abnormality of the anterior horn cell (HP:0006802)1.97340079
108Degeneration of anterior horn cells (HP:0002398)1.97340079
109Abnormality of renal resorption (HP:0011038)1.96798119
110Progressive neurologic deterioration (HP:0002344)1.96217921
111Congenital stationary night blindness (HP:0007642)1.94033194
112Postural tremor (HP:0002174)1.93427228
113Insulin-resistant diabetes mellitus (HP:0000831)1.92773310
114Late onset (HP:0003584)1.91341849
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90872089
116Reduced antithrombin III activity (HP:0001976)1.88809668
117CNS demyelination (HP:0007305)1.88397201
118Muscle fiber atrophy (HP:0100295)1.88096420
119Urethral obstruction (HP:0000796)1.88031760
120Muscle fibrillation (HP:0010546)1.86968093
121Oral leukoplakia (HP:0002745)1.86789531
122Proximal tubulopathy (HP:0000114)1.84586129
123Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84191525
124Cardiovascular calcification (HP:0011915)1.84078440
125Tubular atrophy (HP:0000092)1.83862966
126Abnormality of the pancreatic islet cells (HP:0006476)1.82486682
127Abnormality of endocrine pancreas physiology (HP:0012093)1.82486682
128Testicular atrophy (HP:0000029)1.80990036
129Emotional lability (HP:0000712)1.80283216
130Hyperphosphaturia (HP:0003109)1.79921682
131Pheochromocytoma (HP:0002666)1.79834867
132X-linked dominant inheritance (HP:0001423)1.77362796
133Irregular epiphyses (HP:0010582)1.77036661
134Patent foramen ovale (HP:0001655)1.75472680
135Focal motor seizures (HP:0011153)1.72875238
136Breast hypoplasia (HP:0003187)1.71253633
137Abnormal trabecular bone morphology (HP:0100671)1.70833731
138Atonic seizures (HP:0010819)1.70073714
139Thrombocytosis (HP:0001894)1.68951712
140Pancytopenia (HP:0001876)1.68305668
141IgM deficiency (HP:0002850)1.67752424
142Aplasia/hypoplasia of the uterus (HP:0008684)1.67596508
143Macrocytic anemia (HP:0001972)1.66301115
144Abnormality of the preputium (HP:0100587)1.66273407
145IgG deficiency (HP:0004315)1.65173619
146Abnormal pupillary function (HP:0007686)1.65057693
14711 pairs of ribs (HP:0000878)1.62569491
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.61994062
149Hypoplasia of the fovea (HP:0007750)1.61994062
150Cleft eyelid (HP:0000625)1.61947481
151Poor suck (HP:0002033)1.60221555
152Poor coordination (HP:0002370)1.60209450
153Gliosis (HP:0002171)1.58683030
154Vacuolated lymphocytes (HP:0001922)1.58549003
155Postnatal microcephaly (HP:0005484)1.58532138
156Recurrent bacterial skin infections (HP:0005406)1.57244826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.02392328
2STK164.03578651
3MAP3K123.30250379
4EIF2AK13.22635541
5WNK33.08771898
6MAP4K22.91183962
7NME12.69862991
8CASK2.63736669
9EIF2AK32.49619853
10BUB12.47713400
11PHKG12.39988564
12PHKG22.39988564
13NME22.36612889
14TSSK62.35256799
15PBK2.28012467
16FGFR22.25838357
17VRK12.20775297
18SRPK12.16086131
19PIM22.07904118
20GRK12.07210102
21WEE11.93433291
22MST41.89739090
23MAP2K71.88314288
24TRIM281.84672798
25CCNB11.64558369
26CDK81.62439707
27VRK21.61841372
28ZAK1.61593982
29IRAK31.57299350
30FER1.54531746
31TXK1.51478797
32MYLK1.50898220
33IRAK41.48698665
34MAP2K61.48484464
35NUAK11.48149225
36PLK41.44559595
37MKNK21.42572019
38BMPR21.42053886
39MAP3K141.39331676
40ARAF1.36986499
41CDK191.35332345
42BMPR1B1.33680160
43CSNK1G11.29039357
44PAK31.29004055
45STK31.28057627
46INSRR1.26738848
47MKNK11.24197259
48PLK21.22659472
49TNIK1.22307852
50EIF2AK21.21740109
51ADRBK21.20951356
52TLK11.18770261
53CSNK1G31.17415479
54PINK11.15008785
55YES11.13304757
56TRPM71.13124180
57SIK31.13033838
58TEC1.11270894
59DAPK21.10338006
60AKT31.09740327
61TESK11.09057795
62BLK1.08702515
63MAPKAPK31.08192973
64PASK1.07413206
65BRSK21.06507667
66LIMK11.03676763
67ACVR1B1.03537594
68CSNK1G21.00417930
69TESK21.00144313
70STK390.97949588
71GRK70.97241860
72DAPK10.96904654
73BRAF0.95109058
74BCR0.94731471
75ERBB30.94187484
76PLK30.92327052
77CAMKK20.92130755
78PRKCI0.90376273
79KIT0.87754672
80WNK40.87232663
81CAMK2D0.85387012
82STK38L0.84871739
83STK40.84760790
84KDR0.82201476
85IKBKE0.80539693
86NTRK30.80410950
87RIPK40.79224067
88MUSK0.78999142
89FGFR30.77285513
90BCKDK0.75753233
91TBK10.72481076
92CSNK1A1L0.70923886
93OBSCN0.70277401
94CDC70.68230961
95IKBKB0.67837178
96STK240.64721455
97NLK0.61568735
98NEK60.61060969
99PDK20.60250326
100BRSK10.59105959
101CSNK2A10.59032390
102PLK10.58979253
103LYN0.58001136
104MAP3K110.56275046
105SYK0.54997047
106PTK2B0.54939873
107AURKA0.53731717
108TYK20.53487139
109FES0.52794590
110MAP3K20.52752947
111GRK50.52046335
112PRKD30.51236977
113PNCK0.50634791
114NEK10.49790946
115MAPK130.48901307
116ABL20.48828817
117JAK30.48804041
118ATR0.47605845
119NEK90.46651853
120PAK40.44238711
121CSNK1A10.44055663
122TNK20.43857926
123AURKB0.43038451
124IRAK10.41455433
125RPS6KA40.41041477
126CSNK2A20.40937275
127CAMK2A0.40250689
128TAF10.39885000
129RPS6KA50.39370916
130MAP3K40.37788664
131DYRK20.37656689
132FLT30.37397529
133LCK0.35415299
134PRKCE0.34587842
135TGFBR10.34448239
136ILK0.33722779
137BTK0.33437037
138MAP3K50.33283938
139DAPK30.32642056
140PRKCD0.32146250
141ADRBK10.31347057
142MAPKAPK50.30396970
143AKT20.30112985
144PRKCG0.30102385
145OXSR10.29854447
146GSK3A0.29368491
147PRKG10.28783322
148PRKACA0.28471576
149CAMK2G0.26809559
150MAP3K90.25839853
151PRKACB0.25016836
152ATM0.24440439

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67351578
2Oxidative phosphorylation_Homo sapiens_hsa001903.97645569
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.65060742
4Parkinsons disease_Homo sapiens_hsa050123.26143337
5Protein export_Homo sapiens_hsa030603.25681059
6Ribosome_Homo sapiens_hsa030103.19235944
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16872991
8RNA polymerase_Homo sapiens_hsa030202.87070651
9DNA replication_Homo sapiens_hsa030302.59189125
10Huntingtons disease_Homo sapiens_hsa050162.48199726
11Alzheimers disease_Homo sapiens_hsa050102.37219560
12Butanoate metabolism_Homo sapiens_hsa006502.34659098
13Mismatch repair_Homo sapiens_hsa034302.25648463
14Vitamin B6 metabolism_Homo sapiens_hsa007502.19047178
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18741967
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13860173
17Collecting duct acid secretion_Homo sapiens_hsa049662.13103788
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12609918
19Fatty acid elongation_Homo sapiens_hsa000622.06214542
20Homologous recombination_Homo sapiens_hsa034401.96830087
21Pyrimidine metabolism_Homo sapiens_hsa002401.96331744
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90680681
23Nucleotide excision repair_Homo sapiens_hsa034201.76574215
24Propanoate metabolism_Homo sapiens_hsa006401.74591663
25Spliceosome_Homo sapiens_hsa030401.70010542
26Type I diabetes mellitus_Homo sapiens_hsa049401.64658059
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61885626
28Vibrio cholerae infection_Homo sapiens_hsa051101.60718990
29Allograft rejection_Homo sapiens_hsa053301.52750890
30Rheumatoid arthritis_Homo sapiens_hsa053231.51095140
31Selenocompound metabolism_Homo sapiens_hsa004501.49843656
32Peroxisome_Homo sapiens_hsa041461.48062445
33Basal transcription factors_Homo sapiens_hsa030221.42816061
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41063963
35Base excision repair_Homo sapiens_hsa034101.39652308
36RNA degradation_Homo sapiens_hsa030181.37612633
37Graft-versus-host disease_Homo sapiens_hsa053321.37557350
38Non-homologous end-joining_Homo sapiens_hsa034501.34339823
39RNA transport_Homo sapiens_hsa030131.32491298
40Glutathione metabolism_Homo sapiens_hsa004801.28064738
41Purine metabolism_Homo sapiens_hsa002301.24683841
42Tryptophan metabolism_Homo sapiens_hsa003801.23019359
43Insulin secretion_Homo sapiens_hsa049111.23010917
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16037478
45Cardiac muscle contraction_Homo sapiens_hsa042601.15820150
46Legionellosis_Homo sapiens_hsa051341.11981865
47Fanconi anemia pathway_Homo sapiens_hsa034601.11771726
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09384169
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09251847
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.08989117
51Phagosome_Homo sapiens_hsa041451.08185087
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06594648
53Synaptic vesicle cycle_Homo sapiens_hsa047211.04984221
54Arginine biosynthesis_Homo sapiens_hsa002201.02576270
55Asthma_Homo sapiens_hsa053101.01217720
56Fatty acid metabolism_Homo sapiens_hsa012120.98014881
57Circadian rhythm_Homo sapiens_hsa047100.95181647
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94525801
59Autoimmune thyroid disease_Homo sapiens_hsa053200.93877594
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91510193
61Ether lipid metabolism_Homo sapiens_hsa005650.90530255
62Cell cycle_Homo sapiens_hsa041100.90049241
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89909728
64Epstein-Barr virus infection_Homo sapiens_hsa051690.89874874
65beta-Alanine metabolism_Homo sapiens_hsa004100.84432563
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84286070
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83882563
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83269086
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82193620
70Retinol metabolism_Homo sapiens_hsa008300.81170071
71Other glycan degradation_Homo sapiens_hsa005110.80942282
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80908833
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80100910
74Chemical carcinogenesis_Homo sapiens_hsa052040.79293701
75Fatty acid degradation_Homo sapiens_hsa000710.77508077
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76867540
77Mineral absorption_Homo sapiens_hsa049780.76856266
78Herpes simplex infection_Homo sapiens_hsa051680.76503981
79Pyruvate metabolism_Homo sapiens_hsa006200.76498721
80Nicotine addiction_Homo sapiens_hsa050330.75282504
81Measles_Homo sapiens_hsa051620.75062311
82Antigen processing and presentation_Homo sapiens_hsa046120.73590845
83Steroid biosynthesis_Homo sapiens_hsa001000.73558815
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73297360
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72334503
86Nitrogen metabolism_Homo sapiens_hsa009100.71934272
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70670814
88One carbon pool by folate_Homo sapiens_hsa006700.68402363
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.68169416
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65881910
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65598399
92Linoleic acid metabolism_Homo sapiens_hsa005910.64793587
93Hematopoietic cell lineage_Homo sapiens_hsa046400.64355704
94Primary immunodeficiency_Homo sapiens_hsa053400.61343163
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60578353
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60447974
97Caffeine metabolism_Homo sapiens_hsa002320.59301283
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58641482
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57496186
100Regulation of autophagy_Homo sapiens_hsa041400.56915344
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56665032
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.55728950
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55710420
104p53 signaling pathway_Homo sapiens_hsa041150.55668720
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.54787869
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51440554
107Systemic lupus erythematosus_Homo sapiens_hsa053220.48306225
108Pertussis_Homo sapiens_hsa051330.47248912
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46279914
110Leishmaniasis_Homo sapiens_hsa051400.44914474
111Tuberculosis_Homo sapiens_hsa051520.43951123
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.43404671
113African trypanosomiasis_Homo sapiens_hsa051430.43224374
114N-Glycan biosynthesis_Homo sapiens_hsa005100.42071259
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.41796426
116Arginine and proline metabolism_Homo sapiens_hsa003300.41657581
117Influenza A_Homo sapiens_hsa051640.41250123
118Metabolic pathways_Homo sapiens_hsa011000.41057156
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40550427
120Tyrosine metabolism_Homo sapiens_hsa003500.40421499
121Shigellosis_Homo sapiens_hsa051310.40328424
122Glucagon signaling pathway_Homo sapiens_hsa049220.39721708
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38865171
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38778622
125Arachidonic acid metabolism_Homo sapiens_hsa005900.37428737
126Starch and sucrose metabolism_Homo sapiens_hsa005000.37156573
127Fat digestion and absorption_Homo sapiens_hsa049750.36092681
128Fructose and mannose metabolism_Homo sapiens_hsa000510.34902278
129Serotonergic synapse_Homo sapiens_hsa047260.33814364
130Phototransduction_Homo sapiens_hsa047440.33238991
131Carbon metabolism_Homo sapiens_hsa012000.32937348
132Alcoholism_Homo sapiens_hsa050340.32572629
133Oocyte meiosis_Homo sapiens_hsa041140.31897771
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30997494
135Malaria_Homo sapiens_hsa051440.30921494
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30578256
137Salmonella infection_Homo sapiens_hsa051320.28035930
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28020837
139mRNA surveillance pathway_Homo sapiens_hsa030150.27596559
140Galactose metabolism_Homo sapiens_hsa000520.26906752
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26641114
142Sphingolipid metabolism_Homo sapiens_hsa006000.26570944
143Taste transduction_Homo sapiens_hsa047420.25681372
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25092937
145Lysosome_Homo sapiens_hsa041420.25075371
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23936983
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.21273848
148Pentose phosphate pathway_Homo sapiens_hsa000300.20790406
149Sulfur metabolism_Homo sapiens_hsa009200.20500527
150Folate biosynthesis_Homo sapiens_hsa007900.20349245
151Viral carcinogenesis_Homo sapiens_hsa052030.20025233
152Apoptosis_Homo sapiens_hsa042100.19438639

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