NAA25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.07239185
2nuclear pore complex assembly (GO:0051292)4.91825168
3IMP biosynthetic process (GO:0006188)4.49550279
4DNA replication initiation (GO:0006270)4.47689629
5DNA unwinding involved in DNA replication (GO:0006268)4.31650999
6maturation of SSU-rRNA (GO:0030490)4.26282737
7mitotic nuclear envelope disassembly (GO:0007077)4.22199177
8nucleobase biosynthetic process (GO:0046112)4.21263260
9folic acid-containing compound biosynthetic process (GO:0009396)4.11613814
10DNA strand elongation involved in DNA replication (GO:0006271)4.11295206
11formation of translation preinitiation complex (GO:0001731)4.06841789
12regulation of helicase activity (GO:0051095)4.02555424
13mitotic metaphase plate congression (GO:0007080)4.01008884
14ribosome biogenesis (GO:0042254)3.99013446
15membrane disassembly (GO:0030397)3.95445512
16nuclear envelope disassembly (GO:0051081)3.95445512
17ribosome assembly (GO:0042255)3.94505297
18DNA strand elongation (GO:0022616)3.92297728
19IMP metabolic process (GO:0046040)3.90060494
20telomere maintenance via semi-conservative replication (GO:0032201)3.87921546
21purine nucleobase biosynthetic process (GO:0009113)3.86963908
22protein localization to kinetochore (GO:0034501)3.86271287
23non-recombinational repair (GO:0000726)3.84471895
24double-strand break repair via nonhomologous end joining (GO:0006303)3.84471895
25pore complex assembly (GO:0046931)3.80597619
26DNA replication checkpoint (GO:0000076)3.80240277
27ribosomal large subunit biogenesis (GO:0042273)3.78767617
28DNA replication-dependent nucleosome assembly (GO:0006335)3.77031308
29DNA replication-dependent nucleosome organization (GO:0034723)3.77031308
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67912115
31chromatin remodeling at centromere (GO:0031055)3.65329716
32ribonucleoprotein complex biogenesis (GO:0022613)3.62448298
33regulation of mitotic spindle checkpoint (GO:1903504)3.58798941
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58798941
35telomere maintenance via recombination (GO:0000722)3.56486971
36CENP-A containing nucleosome assembly (GO:0034080)3.56014333
37kinetochore organization (GO:0051383)3.51335566
38rRNA modification (GO:0000154)3.50196202
39metaphase plate congression (GO:0051310)3.49746518
40DNA geometric change (GO:0032392)3.46676630
41mitotic recombination (GO:0006312)3.46611622
42DNA duplex unwinding (GO:0032508)3.46259729
43DNA double-strand break processing (GO:0000729)3.40803507
44recombinational repair (GO:0000725)3.40528799
45telomere maintenance via telomere lengthening (GO:0010833)3.40004343
46double-strand break repair via homologous recombination (GO:0000724)3.39346604
47regulation of DNA endoreduplication (GO:0032875)3.38749091
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35124530
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.35124530
50rRNA processing (GO:0006364)3.34219623
51ribosomal small subunit assembly (GO:0000028)3.34120256
52DNA catabolic process, exonucleolytic (GO:0000738)3.33206158
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.32743986
54DNA replication-independent nucleosome assembly (GO:0006336)3.31764285
55DNA replication-independent nucleosome organization (GO:0034724)3.31764285
56maturation of 5.8S rRNA (GO:0000460)3.27314185
57regulation of centriole replication (GO:0046599)3.26976190
58rRNA metabolic process (GO:0016072)3.24915714
59regulation of centrosome cycle (GO:0046605)3.24081143
60spliceosomal snRNP assembly (GO:0000387)3.22798486
61mitotic sister chromatid segregation (GO:0000070)3.22430969
62regulation of histone H3-K9 methylation (GO:0051570)3.21296262
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19569456
64histone exchange (GO:0043486)3.18458435
65establishment of chromosome localization (GO:0051303)3.17301506
66protein localization to chromosome, centromeric region (GO:0071459)3.14599583
67DNA ligation (GO:0006266)3.12625300
68regulation of centrosome duplication (GO:0010824)3.12601327
69meiotic chromosome segregation (GO:0045132)3.09894580
70synapsis (GO:0007129)3.07655625
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06373534
72protein K6-linked ubiquitination (GO:0085020)3.06227105
73proteasome assembly (GO:0043248)3.06182642
74regulation of spindle organization (GO:0090224)3.06059932
75regulation of gene silencing by miRNA (GO:0060964)3.05496037
76regulation of gene silencing by RNA (GO:0060966)3.05496037
77regulation of posttranscriptional gene silencing (GO:0060147)3.05496037
78telomere organization (GO:0032200)3.04886339
79DNA topological change (GO:0006265)3.03927354
80sister chromatid segregation (GO:0000819)3.03906180
81telomere maintenance (GO:0000723)3.03871990
82rRNA methylation (GO:0031167)3.03163891
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.02660247
84response to X-ray (GO:0010165)3.02293285
85attachment of spindle microtubules to kinetochore (GO:0008608)3.01982757
86mitotic chromosome condensation (GO:0007076)3.01801236
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01268902
88kinetochore assembly (GO:0051382)3.00208884
89mitotic sister chromatid cohesion (GO:0007064)2.99862282
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98456581
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.98090148
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98090148
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98090148
94negative regulation of sister chromatid segregation (GO:0033046)2.98090148
95negative regulation of chromosome segregation (GO:0051985)2.97829900
96histone H2A acetylation (GO:0043968)2.97468557
97peptidyl-arginine omega-N-methylation (GO:0035247)2.97280980
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96300407
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96300407
100isotype switching (GO:0045190)2.96300407
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96020767
102spindle checkpoint (GO:0031577)2.95433815
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95073687
104regulation of sister chromatid segregation (GO:0033045)2.94968564
105regulation of mitotic sister chromatid separation (GO:0010965)2.94968564
106regulation of mitotic sister chromatid segregation (GO:0033047)2.94968564
107regulation of translational fidelity (GO:0006450)2.94796530
108DNA strand renaturation (GO:0000733)2.94633503
109prenylation (GO:0097354)2.94476625
110protein prenylation (GO:0018342)2.94476625
111tRNA aminoacylation for protein translation (GO:0006418)2.92513177
112spindle assembly checkpoint (GO:0071173)2.92292319
113nuclear envelope organization (GO:0006998)2.91750620
114spliceosomal complex assembly (GO:0000245)2.91674795
115mismatch repair (GO:0006298)2.91338572
116postreplication repair (GO:0006301)2.90861727
117regulation of telomere maintenance via telomerase (GO:0032210)2.90419058
118negative regulation of DNA recombination (GO:0045910)2.90327191
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.89283455
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88628113
121mRNA transport (GO:0051028)2.88530435
122mitotic spindle assembly checkpoint (GO:0007094)2.88403148
123regulation of translational termination (GO:0006449)2.88241658
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88232659
125transcription-coupled nucleotide-excision repair (GO:0006283)2.88145129
126mitotic G2/M transition checkpoint (GO:0044818)2.87738448
127mitochondrial RNA metabolic process (GO:0000959)2.87567164
128double-strand break repair (GO:0006302)2.87258010
129replication fork processing (GO:0031297)2.86997992
130pseudouridine synthesis (GO:0001522)2.86645121
131mitotic spindle checkpoint (GO:0071174)2.86621322
132sister chromatid cohesion (GO:0007062)2.86273383
133somatic recombination of immunoglobulin gene segments (GO:0016447)2.85349323
134amino acid activation (GO:0043038)2.85205271
135telomere maintenance via telomerase (GO:0007004)2.81174779
136somatic diversification of immunoglobulins (GO:0016445)2.78895531
137resolution of meiotic recombination intermediates (GO:0000712)2.78090824
138positive regulation of histone H3-K4 methylation (GO:0051571)2.77683417
139DNA-dependent DNA replication (GO:0006261)2.76593954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.64125830
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.52891814
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02916113
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.91027057
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24728030
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18288844
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11690484
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05675596
9MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01120049
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.95068173
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.75047184
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74791809
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.71074379
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66099792
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60944280
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50989448
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50210157
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.40982776
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39005606
20ZNF274_21170338_ChIP-Seq_K562_Hela2.37043542
21EWS_26573619_Chip-Seq_HEK293_Human2.36626169
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33275639
23FUS_26573619_Chip-Seq_HEK293_Human2.32121214
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.31345210
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28142470
26VDR_23849224_ChIP-Seq_CD4+_Human2.24754648
27XRN2_22483619_ChIP-Seq_HELA_Human2.22546432
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19154746
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.12011130
30AR_21909140_ChIP-Seq_LNCAP_Human2.06437469
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04211398
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01646976
33* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01480661
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94858908
35FOXP3_21729870_ChIP-Seq_TREG_Human1.94749542
36ELK1_19687146_ChIP-ChIP_HELA_Human1.94514420
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92764273
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92062579
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91053563
40TAF15_26573619_Chip-Seq_HEK293_Human1.89192283
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87296127
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87089726
43DCP1A_22483619_ChIP-Seq_HELA_Human1.86563824
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.82460724
45TTF2_22483619_ChIP-Seq_HELA_Human1.79870189
46VDR_22108803_ChIP-Seq_LS180_Human1.79212780
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.78964381
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78829506
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73791596
50GABP_19822575_ChIP-Seq_HepG2_Human1.70196387
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66973032
52IGF1R_20145208_ChIP-Seq_DFB_Human1.66907854
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64901790
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63898794
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61550789
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60676570
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59776184
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51726873
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.50468051
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49288822
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48444616
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47860462
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46896273
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46554651
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45577567
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45186364
67CIITA_25753668_ChIP-Seq_RAJI_Human1.44444684
68GBX2_23144817_ChIP-Seq_PC3_Human1.43224744
69* P300_19829295_ChIP-Seq_ESCs_Human1.43073016
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41729314
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.40635569
72KDM5A_27292631_Chip-Seq_BREAST_Human1.32085578
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30599650
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29855136
75IRF1_19129219_ChIP-ChIP_H3396_Human1.28903361
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.27894771
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.26598542
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25576661
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24926943
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24057960
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20420602
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19773230
83ER_23166858_ChIP-Seq_MCF-7_Human1.18821061
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16497376
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16401221
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.16208666
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14016655
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12288447
89MYC_18940864_ChIP-ChIP_HL60_Human1.11242429
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10580879
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10422200
92CBP_20019798_ChIP-Seq_JUKART_Human1.10261926
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10261926
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09011338
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07617798
96TFEB_21752829_ChIP-Seq_HELA_Human1.05330665
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05009825
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04905189
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04066985
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04066985
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04066985
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03854945
103* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03788917
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03373606
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02341006
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02060056
107MYC_22102868_ChIP-Seq_BL_Human1.02058998
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01768705
109STAT3_23295773_ChIP-Seq_U87_Human1.01507245
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00270639
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99675969
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98605503
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98392992
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98329548
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98199054
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96436153
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.95655199
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.95633657
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95293292
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94759225
121* SMAD4_21799915_ChIP-Seq_A2780_Human0.94534218
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93970053
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93711506
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.93439443
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90208234
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90189627
127TP53_22573176_ChIP-Seq_HFKS_Human0.90144827
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.89714045
129KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89546526
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89376941
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88775226
132TCF4_23295773_ChIP-Seq_U87_Human0.88628388
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88288107
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88223567
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88045577
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87569763
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.87170043
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86091452
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84639076
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83787114
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.83285023
142CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83240893
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79559657
144SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78512422
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78210907
146* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78098341
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78026713
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77235191
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76752541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.25701376
2MP0010094_abnormal_chromosome_stability4.94632757
3MP0003111_abnormal_nucleus_morphology4.45417534
4MP0004957_abnormal_blastocyst_morpholog4.26619719
5MP0008057_abnormal_DNA_replication4.19156646
6MP0003077_abnormal_cell_cycle3.98004625
7MP0008058_abnormal_DNA_repair3.81387274
8MP0008007_abnormal_cellular_replicative3.05417232
9MP0010352_gastrointestinal_tract_polyps2.98862531
10MP0003123_paternal_imprinting2.80262555
11MP0010307_abnormal_tumor_latency2.75689025
12MP0008932_abnormal_embryonic_tissue2.60701127
13MP0000350_abnormal_cell_proliferation2.48233945
14MP0002396_abnormal_hematopoietic_system2.43043276
15MP0008877_abnormal_DNA_methylation2.40996741
16MP0001730_embryonic_growth_arrest2.37906526
17MP0006292_abnormal_olfactory_placode2.06332389
18MP0006072_abnormal_retinal_apoptosis1.99097146
19MP0003786_premature_aging1.95067520
20MP0002102_abnormal_ear_morphology1.93690241
21MP0000372_irregular_coat_pigmentation1.89480565
22MP0003890_abnormal_embryonic-extraembry1.81591914
23MP0001672_abnormal_embryogenesis/_devel1.80883716
24MP0005380_embryogenesis_phenotype1.80883716
25MP0002938_white_spotting1.80393201
26MP0001697_abnormal_embryo_size1.78962941
27MP0003121_genomic_imprinting1.74427965
28MP0003984_embryonic_growth_retardation1.64813701
29MP0005253_abnormal_eye_physiology1.64379870
30MP0002088_abnormal_embryonic_growth/wei1.60385005
31MP0003941_abnormal_skin_development1.59914155
32MP0004197_abnormal_fetal_growth/weight/1.58830347
33MP0002080_prenatal_lethality1.58435969
34MP0002084_abnormal_developmental_patter1.53109783
35MP0002085_abnormal_embryonic_tissue1.52122367
36MP0000313_abnormal_cell_death1.48069503
37MP0005076_abnormal_cell_differentiation1.45146281
38MP0002086_abnormal_extraembryonic_tissu1.44394595
39MP0001293_anophthalmia1.40876132
40MP0000490_abnormal_crypts_of1.37825310
41MP0003567_abnormal_fetal_cardiomyocyte1.33456057
42MP0002019_abnormal_tumor_incidence1.28639643
43MP0005551_abnormal_eye_electrophysiolog1.28470647
44MP0004808_abnormal_hematopoietic_stem1.27839344
45MP0003718_maternal_effect1.25085351
46MP0001529_abnormal_vocalization1.24749832
47MP0004147_increased_porphyrin_level1.21701409
48MP0010030_abnormal_orbit_morphology1.20677213
49MP0002009_preneoplasia1.19898448
50MP0002210_abnormal_sex_determination1.19173260
51MP0000647_abnormal_sebaceous_gland1.16963292
52MP0008789_abnormal_olfactory_epithelium1.14683838
53MP0005075_abnormal_melanosome_morpholog1.12616403
54MP0003806_abnormal_nucleotide_metabolis1.09889512
55MP0002254_reproductive_system_inflammat1.09747615
56MP0003221_abnormal_cardiomyocyte_apopto1.09553879
57MP0005367_renal/urinary_system_phenotyp1.09495295
58MP0000516_abnormal_urinary_system1.09495295
59MP0000427_abnormal_hair_cycle1.09427959
60MP0006036_abnormal_mitochondrial_physio1.09183878
61MP0003787_abnormal_imprinting1.07267722
62MP0000703_abnormal_thymus_morphology1.06417095
63MP0001145_abnormal_male_reproductive1.05024690
64MP0000537_abnormal_urethra_morphology1.01980133
65MP0009379_abnormal_foot_pigmentation1.00140079
66MP0005391_vision/eye_phenotype0.98758127
67MP0001929_abnormal_gametogenesis0.96563482
68MP0003943_abnormal_hepatobiliary_system0.95720692
69MP0001188_hyperpigmentation0.94548675
70MP0005187_abnormal_penis_morphology0.93881913
71MP0003763_abnormal_thymus_physiology0.92623418
72MP0005384_cellular_phenotype0.91558625
73MP0000383_abnormal_hair_follicle0.90931001
74MP0002160_abnormal_reproductive_system0.90725833
75MP0001346_abnormal_lacrimal_gland0.89820919
76MP0002095_abnormal_skin_pigmentation0.89353564
77MP0004215_abnormal_myocardial_fiber0.89000359
78MP0000653_abnormal_sex_gland0.87380659
79MP0002233_abnormal_nose_morphology0.87227327
80MP0005499_abnormal_olfactory_system0.86906370
81MP0005394_taste/olfaction_phenotype0.86906370
82MP0000566_synostosis0.86377569
83MP0008995_early_reproductive_senescence0.86304369
84MP0003195_calcinosis0.86246591
85MP0005174_abnormal_tail_pigmentation0.85297837
86MP0005621_abnormal_cell_physiology0.84917700
87MP0003119_abnormal_digestive_system0.84387464
88MP0004133_heterotaxia0.84146932
89MP0005395_other_phenotype0.84100287
90MP0002398_abnormal_bone_marrow0.83798877
91MP0000358_abnormal_cell_content/0.83665647
92MP0002234_abnormal_pharynx_morphology0.83637011
93MP0002090_abnormal_vision0.82837520
94MP0000015_abnormal_ear_pigmentation0.82702884
95MP0008872_abnormal_physiological_respon0.81922443
96MP0001915_intracranial_hemorrhage0.81757858
97MP0002111_abnormal_tail_morphology0.78927860
98MP0005389_reproductive_system_phenotype0.78224558
99MP0002722_abnormal_immune_system0.76162505
100MP0000631_abnormal_neuroendocrine_gland0.75429929
101MP0002837_dystrophic_cardiac_calcinosis0.74059113
102MP0002736_abnormal_nociception_after0.73956993
103MP0009703_decreased_birth_body0.73380985
104MP0001286_abnormal_eye_development0.73337772
105MP0009333_abnormal_splenocyte_physiolog0.73300664
106MP0009672_abnormal_birth_weight0.73107891
107MP0010678_abnormal_skin_adnexa0.72576053
108MP0002697_abnormal_eye_size0.72409016
109MP0003315_abnormal_perineum_morphology0.72010679
110MP0003755_abnormal_palate_morphology0.71290174
111MP0001119_abnormal_female_reproductive0.71165822
112MP0000689_abnormal_spleen_morphology0.70813035
113MP0005397_hematopoietic_system_phenotyp0.70699968
114MP0001545_abnormal_hematopoietic_system0.70699968
115MP0000858_altered_metastatic_potential0.69792586
116MP0001324_abnormal_eye_pigmentation0.68448122
117MP0000569_abnormal_digit_pigmentation0.68440582
118MP0001177_atelectasis0.68006396
119MP0002877_abnormal_melanocyte_morpholog0.67916443
120MP0008770_decreased_survivor_rate0.67891881
121MP0008775_abnormal_heart_ventricle0.67272692
122MP0003566_abnormal_cell_adhesion0.67217614
123MP0003646_muscle_fatigue0.66737282
124MP0003186_abnormal_redox_activity0.66586624
125MP0002638_abnormal_pupillary_reflex0.65851712
126MP0004142_abnormal_muscle_tone0.65179964
127MP0003937_abnormal_limbs/digits/tail_de0.64574347
128MP0005645_abnormal_hypothalamus_physiol0.64203430
129MP0009046_muscle_twitch0.63748724
130MP0002751_abnormal_autonomic_nervous0.62376144
131MP0002075_abnormal_coat/hair_pigmentati0.60809715
132MP0003698_abnormal_male_reproductive0.60658236
133MP0000371_diluted_coat_color0.60649682
134MP0000428_abnormal_craniofacial_morphol0.59238636
135MP0003861_abnormal_nervous_system0.58956781
136MP0004264_abnormal_extraembryonic_tissu0.58215598
137MP0002429_abnormal_blood_cell0.57985244
138MP0006035_abnormal_mitochondrial_morpho0.57642909
139MP0004233_abnormal_muscle_weight0.57099826
140MP0009697_abnormal_copulation0.56186436
141MP0005501_abnormal_skin_physiology0.55916984
142MP0005266_abnormal_metabolism0.55309636

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.35832255
2Chromsome breakage (HP:0040012)4.28734794
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06895639
4Breast hypoplasia (HP:0003187)3.93706022
5Ependymoma (HP:0002888)3.86838597
6Colon cancer (HP:0003003)3.81555020
7Medulloblastoma (HP:0002885)3.73515138
8Agnosia (HP:0010524)3.65563739
9Abnormality of the labia minora (HP:0012880)3.62529693
10Selective tooth agenesis (HP:0001592)3.60888546
11Abnormality of chromosome stability (HP:0003220)3.47891902
12Oral leukoplakia (HP:0002745)3.47617363
13Reticulocytopenia (HP:0001896)3.15264633
14Abnormality of the preputium (HP:0100587)3.05380659
15Patellar aplasia (HP:0006443)3.03290629
16Abnormality of alanine metabolism (HP:0010916)3.01476254
17Hyperalaninemia (HP:0003348)3.01476254
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01476254
19Pancreatic cysts (HP:0001737)2.90477636
20Rough bone trabeculation (HP:0100670)2.89584040
21Aplasia/Hypoplasia of the patella (HP:0006498)2.84726000
2211 pairs of ribs (HP:0000878)2.84468945
23Astrocytoma (HP:0009592)2.84346201
24Abnormality of the astrocytes (HP:0100707)2.84346201
25Pancreatic fibrosis (HP:0100732)2.84322920
26Premature graying of hair (HP:0002216)2.79293316
27Meckel diverticulum (HP:0002245)2.79056758
28Glioma (HP:0009733)2.77787763
29Abnormality of the anterior horn cell (HP:0006802)2.73840825
30Degeneration of anterior horn cells (HP:0002398)2.73840825
31Rhabdomyosarcoma (HP:0002859)2.71306237
32Myelodysplasia (HP:0002863)2.69335239
33Absent thumb (HP:0009777)2.63527190
34Aplastic anemia (HP:0001915)2.62743316
35Impulsivity (HP:0100710)2.61011168
36Abnormality of the ileum (HP:0001549)2.59725437
37Nephronophthisis (HP:0000090)2.58704857
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.58379315
39Abnormal number of incisors (HP:0011064)2.57138837
40Carpal bone hypoplasia (HP:0001498)2.56069043
41Volvulus (HP:0002580)2.55732873
42Abnormality of midbrain morphology (HP:0002418)2.54809386
43Molar tooth sign on MRI (HP:0002419)2.54809386
44Ectopic kidney (HP:0000086)2.52330147
45Bone marrow hypocellularity (HP:0005528)2.47588194
46Amaurosis fugax (HP:0100576)2.45817670
47Duplicated collecting system (HP:0000081)2.42568378
48Absent radius (HP:0003974)2.40907518
49Cellular immunodeficiency (HP:0005374)2.39671867
50Neoplasm of the pancreas (HP:0002894)2.38177456
51Medial flaring of the eyebrow (HP:0010747)2.37769589
52Neoplasm of the oral cavity (HP:0100649)2.36283066
53True hermaphroditism (HP:0010459)2.35764606
54Sloping forehead (HP:0000340)2.32285895
55Supernumerary spleens (HP:0009799)2.29291084
56Cerebral hypomyelination (HP:0006808)2.28854409
57Abnormal trabecular bone morphology (HP:0100671)2.26910812
58Small intestinal stenosis (HP:0012848)2.23348629
59Duodenal stenosis (HP:0100867)2.23348629
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.21988413
61Abnormality of the renal collecting system (HP:0004742)2.20041548
62Aplasia involving forearm bones (HP:0009822)2.20022439
63Absent forearm bone (HP:0003953)2.20022439
64Missing ribs (HP:0000921)2.17582162
65Shoulder girdle muscle weakness (HP:0003547)2.17317334
66Abnormality of the renal medulla (HP:0100957)2.16814462
67Abnormality of the pons (HP:0007361)2.16111171
68Abnormality of cells of the erythroid lineage (HP:0012130)2.13991267
69Progressive inability to walk (HP:0002505)2.13911609
70Pelvic girdle muscle weakness (HP:0003749)2.13754571
71Increased hepatocellular lipid droplets (HP:0006565)2.13042505
72Lipid accumulation in hepatocytes (HP:0006561)2.11017982
73Abnormality of abdominal situs (HP:0011620)2.10168581
74Abdominal situs inversus (HP:0003363)2.10168581
75Chronic hepatic failure (HP:0100626)2.08828523
76Hypoplasia of the pons (HP:0012110)2.08520280
77Tracheoesophageal fistula (HP:0002575)2.07873696
78Pancreatic islet-cell hyperplasia (HP:0004510)2.07720342
79Pallor (HP:0000980)2.07201999
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06820882
81Abnormality of the renal cortex (HP:0011035)2.06182325
82Biliary tract neoplasm (HP:0100574)2.06047518
83Abnormality of serum amino acid levels (HP:0003112)2.06031278
84Cleft eyelid (HP:0000625)2.05543867
85Squamous cell carcinoma (HP:0002860)2.04836937
86Abnormal spermatogenesis (HP:0008669)2.03477634
87Prominent nose (HP:0000448)2.02953312
88Small hand (HP:0200055)2.02890598
89Abnormal number of erythroid precursors (HP:0012131)2.02586950
90Deviation of the thumb (HP:0009603)2.01648979
91Horseshoe kidney (HP:0000085)2.00557645
92Neoplasm of the colon (HP:0100273)2.00149013
93Embryonal renal neoplasm (HP:0011794)1.99083189
94Proximal placement of thumb (HP:0009623)1.98944446
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.98229723
96Cerebellar dysplasia (HP:0007033)1.96443261
97Renal cortical cysts (HP:0000803)1.94565624
98Postaxial foot polydactyly (HP:0001830)1.94291001
99Lymphoma (HP:0002665)1.94179750
100Congenital primary aphakia (HP:0007707)1.93104387
101Genital tract atresia (HP:0001827)1.92832679
102Neoplasm of the adrenal cortex (HP:0100641)1.92607311
103Cafe-au-lait spot (HP:0000957)1.92199692
104Sclerocornea (HP:0000647)1.91983921
105Increased CSF lactate (HP:0002490)1.91579875
106Increased serum lactate (HP:0002151)1.90368681
107Trismus (HP:0000211)1.89550559
108Intestinal atresia (HP:0011100)1.88479732
109Attenuation of retinal blood vessels (HP:0007843)1.88473854
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.88395424
111Clubbing of toes (HP:0100760)1.87107057
112Preaxial hand polydactyly (HP:0001177)1.86597071
113Abnormality of the carotid arteries (HP:0005344)1.86247016
114Abnormality of methionine metabolism (HP:0010901)1.85326922
115Dandy-Walker malformation (HP:0001305)1.85248362
116Neoplasm of striated muscle (HP:0009728)1.84403667
117Type I transferrin isoform profile (HP:0003642)1.82875213
118Atresia of the external auditory canal (HP:0000413)1.81524936
119Basal cell carcinoma (HP:0002671)1.81019635
120Type II lissencephaly (HP:0007260)1.78450978
121Abnormal lung lobation (HP:0002101)1.78423454
122Astigmatism (HP:0000483)1.77660079
123Abnormality of the hip-girdle musculature (HP:0001445)1.76923607
124Abnormality of the musculature of the pelvis (HP:0001469)1.76923607
125Nephrogenic diabetes insipidus (HP:0009806)1.76737698
126Abnormality of the duodenum (HP:0002246)1.76624448
127Gastrointestinal atresia (HP:0002589)1.76162316
128Gait imbalance (HP:0002141)1.76158311
129Increased nuchal translucency (HP:0010880)1.75282193
130Poor coordination (HP:0002370)1.72945539
131Atrophy/Degeneration involving motor neurons (HP:0007373)1.72709994
132Triphalangeal thumb (HP:0001199)1.72613142
133Nephroblastoma (Wilms tumor) (HP:0002667)1.72440096
134Vaginal atresia (HP:0000148)1.72222344
135Abnormal protein glycosylation (HP:0012346)1.72183965
136Abnormal glycosylation (HP:0012345)1.72183965
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72183965
138Abnormal protein N-linked glycosylation (HP:0012347)1.72183965
139Bifid tongue (HP:0010297)1.72114027
140Short thumb (HP:0009778)1.72062364
141Aplasia/hypoplasia of the humerus (HP:0006507)1.71895867
142Aseptic necrosis (HP:0010885)1.71724932
143Congenital stationary night blindness (HP:0007642)1.71328023
144Methylmalonic acidemia (HP:0002912)1.70994451
145Long foot (HP:0001833)1.70051073
146Abolished electroretinogram (ERG) (HP:0000550)1.69486505
147Prominent metopic ridge (HP:0005487)1.68487261
148Anencephaly (HP:0002323)1.67651688
149Breast aplasia (HP:0100783)1.67250755
150Acute encephalopathy (HP:0006846)1.66906827
151Pancytopenia (HP:0001876)1.66725048
152Supernumerary bones of the axial skeleton (HP:0009144)1.66376992
153Microvesicular hepatic steatosis (HP:0001414)1.66256721
154Freckling (HP:0001480)1.65603934
155Irregular epiphyses (HP:0010582)1.65599171
156Slender long bone (HP:0003100)1.65324685
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64862198
158Long clavicles (HP:0000890)1.63825604
1593-Methylglutaconic aciduria (HP:0003535)1.61939881
160Acute necrotizing encephalopathy (HP:0006965)1.61378381
161Pendular nystagmus (HP:0012043)1.59500342
162Central scotoma (HP:0000603)1.58079870
163Oculomotor apraxia (HP:0000657)1.57885334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.09527099
2EIF2AK13.98767444
3CDC73.97472949
4SRPK13.44423617
5BUB13.33301740
6TSSK63.33196064
7FRK2.95262385
8TTK2.86905787
9NEK12.65675555
10PLK42.62757373
11NUAK12.56278802
12WNK32.48478486
13PLK32.35490350
14EPHA22.26447551
15TRIM282.19206730
16ZAK2.10679232
17NEK22.09657139
18PLK12.03638546
19ATR2.01807038
20BRSK22.01692479
21BMPR1B1.97302015
22RPS6KB21.94017427
23MKNK11.85305429
24CDK121.78598288
25MAP4K21.73885446
26BRD41.58399732
27ACVR1B1.56510620
28EIF2AK31.55322683
29CCNB11.54981809
30PASK1.52951879
31VRK11.51525025
32TNIK1.50057502
33AURKB1.46533241
34TLK11.41512338
35CHEK11.40670824
36CDK71.39592032
37MAP3K41.37932820
38MKNK21.37436293
39CHEK21.35982329
40STK161.32675611
41PNCK1.25739214
42BCR1.18960057
43ATM1.15880568
44PLK21.15583819
45TAF11.15192555
46STK38L1.14286486
47ALK1.12878643
48BRSK11.10710272
49NME11.07946814
50NME21.07819251
51SCYL21.07298188
52STK101.01101286
53EEF2K1.01090988
54AURKA1.00950186
55MAP3K81.00499224
56CDK40.98628104
57VRK20.97259162
58DYRK30.96867619
59LATS10.95004478
60STK30.93774569
61GRK10.92525177
62PDK30.91894740
63PDK40.91894740
64EIF2AK20.91654127
65CDK20.91530634
66ERBB30.89641705
67RPS6KA40.89044455
68STK390.86917262
69PAK40.84777865
70CSNK1G10.83492482
71MAPK130.80609354
72PIM20.80591372
73PBK0.78310325
74STK40.75846361
75TGFBR10.73367195
76ADRBK20.72582070
77CLK10.72463892
78MAP2K30.71133378
79WNK40.69409636
80CSNK2A20.69378312
81CDK10.68952895
82PIM10.68932994
83TEC0.68004100
84DAPK10.66446658
85ERBB40.65664206
86FLT30.64364439
87OXSR10.62727989
88AKT30.62278300
89PDK20.60649246
90CSNK1A1L0.59599904
91CSNK2A10.59237646
92TRPM70.58807155
93CSNK1G20.58734963
94PRKCI0.54989119
95CDK80.54905340
96STK240.53357825
97CAMK1G0.53266504
98CDK30.52241304
99LATS20.51767306
100TESK10.51671152
101CSNK1G30.50809829
102PRKDC0.50607891
103OBSCN0.50371781
104INSRR0.47603203
105RPS6KB10.46582282
106MAP3K50.46122066
107MAPKAPK30.45814556
108MAP2K70.45705432
109CSNK1E0.45168779
110FGFR10.43343366
111NLK0.43184678
112TAOK20.42890554
113PAK10.41988040
114FGFR20.40802223
115CDK60.40598823
116MAP3K140.40206380
117BRAF0.39819287
118CSNK1D0.38116326
119CAMK1D0.37644560
120BMPR20.36469359
121PRKCE0.35415231
122MAPK140.35132741
123RPS6KA50.34594827
124MTOR0.32873146
125MST40.32026778
126YES10.31455421
127IRAK30.29410507
128JAK30.28565146
129DYRK20.27194183
130TESK20.26863317
131MAP2K60.26386778
132CASK0.24984055
133CSNK1A10.24244256
134MAP3K60.23429839
135PINK10.23374824
136FER0.23164348
137GSK3B0.21942338
138IKBKB0.21343229
139AKT10.18313108

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43498487
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23991989
3Mismatch repair_Homo sapiens_hsa034304.10723488
4RNA polymerase_Homo sapiens_hsa030203.41135582
5RNA transport_Homo sapiens_hsa030133.37847859
6Proteasome_Homo sapiens_hsa030503.34952711
7Spliceosome_Homo sapiens_hsa030403.22089643
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.09591516
9Homologous recombination_Homo sapiens_hsa034403.01605581
10One carbon pool by folate_Homo sapiens_hsa006702.97523948
11Ribosome_Homo sapiens_hsa030102.68868503
12Nucleotide excision repair_Homo sapiens_hsa034202.65597992
13Base excision repair_Homo sapiens_hsa034102.64429873
14Cell cycle_Homo sapiens_hsa041102.57056238
15Fanconi anemia pathway_Homo sapiens_hsa034602.48148577
16Pyrimidine metabolism_Homo sapiens_hsa002402.44763907
17Non-homologous end-joining_Homo sapiens_hsa034502.37047061
18RNA degradation_Homo sapiens_hsa030182.21608373
19Propanoate metabolism_Homo sapiens_hsa006402.11260014
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01401052
21mRNA surveillance pathway_Homo sapiens_hsa030151.97378676
22Basal transcription factors_Homo sapiens_hsa030221.88903393
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59168929
24p53 signaling pathway_Homo sapiens_hsa041151.56354963
25Epstein-Barr virus infection_Homo sapiens_hsa051691.49221446
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47022124
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41591266
28Vitamin B6 metabolism_Homo sapiens_hsa007501.39060515
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36882871
30Purine metabolism_Homo sapiens_hsa002301.35448544
31Steroid biosynthesis_Homo sapiens_hsa001001.35139969
32Phototransduction_Homo sapiens_hsa047441.34571427
33Systemic lupus erythematosus_Homo sapiens_hsa053221.28876509
34Lysine degradation_Homo sapiens_hsa003101.24021633
35Butanoate metabolism_Homo sapiens_hsa006501.21270750
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18367575
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13863459
38Oocyte meiosis_Homo sapiens_hsa041141.13638961
39Viral carcinogenesis_Homo sapiens_hsa052031.10524934
40Herpes simplex infection_Homo sapiens_hsa051681.09819791
41Antigen processing and presentation_Homo sapiens_hsa046121.09687783
42Nitrogen metabolism_Homo sapiens_hsa009101.00294084
43Pyruvate metabolism_Homo sapiens_hsa006200.96665297
44Oxidative phosphorylation_Homo sapiens_hsa001900.94462331
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78043116
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76198406
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75867216
48Legionellosis_Homo sapiens_hsa051340.74961158
49HTLV-I infection_Homo sapiens_hsa051660.72656390
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72546192
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.70923556
52Biosynthesis of amino acids_Homo sapiens_hsa012300.67834055
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67825690
54Fatty acid elongation_Homo sapiens_hsa000620.66359052
55Circadian rhythm_Homo sapiens_hsa047100.65465178
56Tryptophan metabolism_Homo sapiens_hsa003800.64484372
57MicroRNAs in cancer_Homo sapiens_hsa052060.64401343
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60056671
59Metabolic pathways_Homo sapiens_hsa011000.56406905
60Huntingtons disease_Homo sapiens_hsa050160.56320081
61Caffeine metabolism_Homo sapiens_hsa002320.55507971
62Olfactory transduction_Homo sapiens_hsa047400.53196884
63Apoptosis_Homo sapiens_hsa042100.53071079
64Influenza A_Homo sapiens_hsa051640.52103117
65Alcoholism_Homo sapiens_hsa050340.51915264
66Ether lipid metabolism_Homo sapiens_hsa005650.51875943
67Pentose phosphate pathway_Homo sapiens_hsa000300.51464609
68Measles_Homo sapiens_hsa051620.51434993
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50743258
70Selenocompound metabolism_Homo sapiens_hsa004500.49862781
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49202509
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.48346518
73Peroxisome_Homo sapiens_hsa041460.47120676
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47013513
75Taste transduction_Homo sapiens_hsa047420.46082585
76Hippo signaling pathway_Homo sapiens_hsa043900.44851928
77Colorectal cancer_Homo sapiens_hsa052100.44492652
78Allograft rejection_Homo sapiens_hsa053300.44457315
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44321893
80Small cell lung cancer_Homo sapiens_hsa052220.43114080
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42450358
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42207932
83Hepatitis B_Homo sapiens_hsa051610.41698164
84TGF-beta signaling pathway_Homo sapiens_hsa043500.39648684
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38918575
86HIF-1 signaling pathway_Homo sapiens_hsa040660.38309279
87Thyroid cancer_Homo sapiens_hsa052160.38247329
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36632160
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.36419915
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35329143
91Linoleic acid metabolism_Homo sapiens_hsa005910.35203734
92Type I diabetes mellitus_Homo sapiens_hsa049400.35187041
93Viral myocarditis_Homo sapiens_hsa054160.33211558
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.32293846
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31552890
96beta-Alanine metabolism_Homo sapiens_hsa004100.30117800
97Fatty acid metabolism_Homo sapiens_hsa012120.29939822
98Alzheimers disease_Homo sapiens_hsa050100.29495658
99Shigellosis_Homo sapiens_hsa051310.29273500
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.28787335
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28670839
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.27899987
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.27412607
104Graft-versus-host disease_Homo sapiens_hsa053320.27219627
105Nicotine addiction_Homo sapiens_hsa050330.26836138
106Carbon metabolism_Homo sapiens_hsa012000.26798713
107Fructose and mannose metabolism_Homo sapiens_hsa000510.25788919
108Adherens junction_Homo sapiens_hsa045200.24307686
109Glutathione metabolism_Homo sapiens_hsa004800.23765681
110Folate biosynthesis_Homo sapiens_hsa007900.23380204
111Regulation of autophagy_Homo sapiens_hsa041400.22680058
112N-Glycan biosynthesis_Homo sapiens_hsa005100.22470547
113TNF signaling pathway_Homo sapiens_hsa046680.22401389
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22096864
115Hedgehog signaling pathway_Homo sapiens_hsa043400.21549756
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20170723
117Protein export_Homo sapiens_hsa030600.19089388
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18659363
119Notch signaling pathway_Homo sapiens_hsa043300.18247942
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17576970
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17495342
122Primary immunodeficiency_Homo sapiens_hsa053400.17196463
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17024161
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16946294
125Acute myeloid leukemia_Homo sapiens_hsa052210.16682062
126Melanoma_Homo sapiens_hsa052180.16278049
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.16224761
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16009897
129Galactose metabolism_Homo sapiens_hsa000520.15577404
130Vitamin digestion and absorption_Homo sapiens_hsa049770.15531048
131Pathways in cancer_Homo sapiens_hsa052000.14903772
132FoxO signaling pathway_Homo sapiens_hsa040680.13727229
133Basal cell carcinoma_Homo sapiens_hsa052170.13524994
134Chronic myeloid leukemia_Homo sapiens_hsa052200.13366824
135mTOR signaling pathway_Homo sapiens_hsa041500.12894251
136Retinol metabolism_Homo sapiens_hsa008300.12722264
137Arginine and proline metabolism_Homo sapiens_hsa003300.12456630
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12191523
139Wnt signaling pathway_Homo sapiens_hsa043100.11637449
140Parkinsons disease_Homo sapiens_hsa050120.11510012
141Prostate cancer_Homo sapiens_hsa052150.09254396
142Toxoplasmosis_Homo sapiens_hsa051450.07788338
143Leishmaniasis_Homo sapiens_hsa051400.07780831
144T cell receptor signaling pathway_Homo sapiens_hsa046600.06974403
145Asthma_Homo sapiens_hsa053100.06933659
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06490659
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.05593901
148Hepatitis C_Homo sapiens_hsa051600.05449741

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