NAA60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.84726417
2L-phenylalanine catabolic process (GO:0006559)5.84726417
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.47155703
4L-phenylalanine metabolic process (GO:0006558)5.47155703
5alpha-linolenic acid metabolic process (GO:0036109)5.30319718
6aromatic amino acid family catabolic process (GO:0009074)5.29113546
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.93959495
8tryptophan catabolic process (GO:0006569)4.74468117
9indole-containing compound catabolic process (GO:0042436)4.74468117
10indolalkylamine catabolic process (GO:0046218)4.74468117
11kynurenine metabolic process (GO:0070189)4.74349192
12bile acid biosynthetic process (GO:0006699)4.73299330
13tryptophan metabolic process (GO:0006568)4.50028314
14glyoxylate metabolic process (GO:0046487)4.47761681
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46189042
16lysine metabolic process (GO:0006553)4.41382264
17lysine catabolic process (GO:0006554)4.41382264
18negative regulation of cell killing (GO:0031342)4.39696474
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39696474
20cellular ketone body metabolic process (GO:0046950)4.32833026
21complement activation, alternative pathway (GO:0006957)4.32740687
22high-density lipoprotein particle remodeling (GO:0034375)4.28102527
23urea metabolic process (GO:0019627)4.18892706
24urea cycle (GO:0000050)4.18892706
25regulation of cholesterol esterification (GO:0010872)4.17429780
26sulfur amino acid catabolic process (GO:0000098)4.08252866
27negative regulation of fibrinolysis (GO:0051918)3.98540435
28regulation of protein activation cascade (GO:2000257)3.96699710
29oxaloacetate metabolic process (GO:0006107)3.94956694
30protein carboxylation (GO:0018214)3.88982402
31peptidyl-glutamic acid carboxylation (GO:0017187)3.88982402
32bile acid metabolic process (GO:0008206)3.88703132
33dicarboxylic acid biosynthetic process (GO:0043650)3.85639986
34regulation of triglyceride catabolic process (GO:0010896)3.82965447
35glutamate metabolic process (GO:0006536)3.82670708
36cysteine metabolic process (GO:0006534)3.82349679
37disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.81466628
38killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.81466628
39nitrogen cycle metabolic process (GO:0071941)3.79057028
40coenzyme catabolic process (GO:0009109)3.76643913
41protein-lipid complex remodeling (GO:0034368)3.74748329
42macromolecular complex remodeling (GO:0034367)3.74748329
43plasma lipoprotein particle remodeling (GO:0034369)3.74748329
44regulation of complement activation (GO:0030449)3.73593111
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73581353
46regulation of fibrinolysis (GO:0051917)3.71839626
47ketone body metabolic process (GO:1902224)3.69699722
48negative regulation of erythrocyte differentiation (GO:0045647)3.69093079
49aromatic amino acid family metabolic process (GO:0009072)3.67976192
50reverse cholesterol transport (GO:0043691)3.66760158
51phospholipid efflux (GO:0033700)3.65437872
52alpha-amino acid catabolic process (GO:1901606)3.65200123
53antigen processing and presentation of endogenous antigen (GO:0019883)3.61944425
54amino-acid betaine metabolic process (GO:0006577)3.59503117
55ethanol oxidation (GO:0006069)3.57397159
562-oxoglutarate metabolic process (GO:0006103)3.55205059
57tyrosine metabolic process (GO:0006570)3.53279877
58negative regulation of sterol transport (GO:0032372)3.50551488
59negative regulation of cholesterol transport (GO:0032375)3.50551488
60aspartate family amino acid catabolic process (GO:0009068)3.49199585
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48243342
62low-density lipoprotein particle remodeling (GO:0034374)3.46192023
63succinate metabolic process (GO:0006105)3.43764630
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41691203
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41691203
66positive regulation by organism of defense response of other organism involved in symbiotic interact3.41691203
67modulation by symbiont of host immune response (GO:0052553)3.41691203
68positive regulation by symbiont of host defense response (GO:0052509)3.41691203
69modulation by symbiont of host defense response (GO:0052031)3.41691203
70cellular amino acid catabolic process (GO:0009063)3.41644402
71acylglycerol homeostasis (GO:0055090)3.40538887
72triglyceride homeostasis (GO:0070328)3.40538887
73positive regulation of gamma-delta T cell activation (GO:0046645)3.37189834
74response to peptidoglycan (GO:0032494)3.33939813
75peroxisome fission (GO:0016559)3.33854768
76cellular modified amino acid catabolic process (GO:0042219)3.29703028
77neutrophil activation involved in immune response (GO:0002283)3.26488097
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26413098
79indolalkylamine metabolic process (GO:0006586)3.25724769
80homocysteine metabolic process (GO:0050667)3.25100750
81NIK/NF-kappaB signaling (GO:0038061)3.24879085
82cofactor catabolic process (GO:0051187)3.24666377
83acetyl-CoA metabolic process (GO:0006084)3.24595396
84dicarboxylic acid catabolic process (GO:0043649)3.23462143
85regulation of gamma-delta T cell activation (GO:0046643)3.22496330
86NADH metabolic process (GO:0006734)3.21106051
87mannose metabolic process (GO:0006013)3.20347773
88serine family amino acid catabolic process (GO:0009071)3.19865214
89short-chain fatty acid metabolic process (GO:0046459)3.19610158
90cholesterol efflux (GO:0033344)3.18369853
91tolerance induction (GO:0002507)3.18185688
92regulation of mast cell degranulation (GO:0043304)3.17917199
93bile acid and bile salt transport (GO:0015721)3.16713578
94imidazole-containing compound metabolic process (GO:0052803)3.15414114
95disruption of cells of other organism (GO:0044364)3.12257630
96killing of cells of other organism (GO:0031640)3.12257630
97plasma lipoprotein particle clearance (GO:0034381)3.10963587
98benzene-containing compound metabolic process (GO:0042537)3.10590961
99monocarboxylic acid catabolic process (GO:0072329)3.08652772
100complement activation (GO:0006956)3.08282749
101regulation of gamma-delta T cell differentiation (GO:0045586)3.07760737
102aldehyde catabolic process (GO:0046185)3.06667035
103carboxylic acid catabolic process (GO:0046395)3.06285641
104organic acid catabolic process (GO:0016054)3.06285641
105cellular biogenic amine catabolic process (GO:0042402)3.05280606
106amine catabolic process (GO:0009310)3.05280606
107complement activation, classical pathway (GO:0006958)3.04942151
108positive regulation of lipid catabolic process (GO:0050996)3.02306979
109cytolysis (GO:0019835)3.02114156
110regulation of cholesterol homeostasis (GO:2000188)3.01088363
111arginine metabolic process (GO:0006525)3.00230482
112negative regulation of interleukin-12 production (GO:0032695)2.99595899
113NAD metabolic process (GO:0019674)2.99316099
114plasma lipoprotein particle assembly (GO:0034377)2.98840664
115cholesterol catabolic process (GO:0006707)2.98074215
116sterol catabolic process (GO:0016127)2.98074215
117regulation of T-helper 2 cell differentiation (GO:0045628)2.97701594
118fatty acid catabolic process (GO:0009062)2.97246713
119positive regulation of lipoprotein lipase activity (GO:0051006)2.97216682
120positive regulation of triglyceride lipase activity (GO:0061365)2.97216682
121drug catabolic process (GO:0042737)2.97193266
122opsonization (GO:0008228)2.96513388
123phospholipid homeostasis (GO:0055091)2.95588878
124fatty acid beta-oxidation (GO:0006635)2.95324030
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94473370
126germinal center formation (GO:0002467)2.92176631
127regulation of mast cell activation involved in immune response (GO:0033006)2.91026739
128regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89757643
129barbed-end actin filament capping (GO:0051016)2.83605176
130regulation of leukocyte degranulation (GO:0043300)2.79985190
131immunoglobulin mediated immune response (GO:0016064)2.77806282
132response to type I interferon (GO:0034340)2.77787633
133type I interferon signaling pathway (GO:0060337)2.77472102
134cellular response to type I interferon (GO:0071357)2.77472102
135detection of bacterium (GO:0016045)2.77444520
136modulation by virus of host process (GO:0019054)2.70778049
137positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70761506
138detection of other organism (GO:0098543)2.67857438
139thymic T cell selection (GO:0045061)2.66059014
140regulation of B cell receptor signaling pathway (GO:0050855)2.62027068
141macrophage activation involved in immune response (GO:0002281)2.58959460
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.58496912
143modulation by symbiont of host cellular process (GO:0044068)2.57936904
144regulation of interleukin-12 biosynthetic process (GO:0045075)2.56287810
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.51022228
146neutrophil activation (GO:0042119)2.50498408
147negative regulation of innate immune response (GO:0045824)2.49485457
148response to muramyl dipeptide (GO:0032495)2.48350424
149regulation of autophagic vacuole assembly (GO:2000785)2.47667045
150response to host immune response (GO:0052572)2.45135227
151response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45135227
152negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45012462
153granulocyte activation (GO:0036230)2.44748074
154negative regulation of leukocyte mediated immunity (GO:0002704)2.43755331
155negative regulation of cytokine production involved in immune response (GO:0002719)2.41818501
156T cell selection (GO:0045058)2.41660959
157lipopolysaccharide-mediated signaling pathway (GO:0031663)2.36880188
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.34013036
159regulation of regulated secretory pathway (GO:1903305)2.33616185
160regulation of interferon-beta biosynthetic process (GO:0045357)2.33586181
161negative regulation of type 2 immune response (GO:0002829)2.32276464
162stress fiber assembly (GO:0043149)2.31597798
163diacylglycerol metabolic process (GO:0046339)2.31320682
164negative regulation of granulocyte differentiation (GO:0030853)2.31272638
165regulation of dendritic cell antigen processing and presentation (GO:0002604)2.30381699
166actin filament polymerization (GO:0030041)2.30344981
167detection of external biotic stimulus (GO:0098581)2.30304718
168regulation of vacuole organization (GO:0044088)2.27789236
169regulation of podosome assembly (GO:0071801)2.27457132
170negative regulation of interleukin-6 production (GO:0032715)2.27387479
171regulation of type 2 immune response (GO:0002828)2.27088962
172response to host (GO:0075136)2.26979992
173response to host defenses (GO:0052200)2.26979992
174response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26979992
175positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26784565
176phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.26557274
177positive regulation of type 2 immune response (GO:0002830)2.26429732
178regulation of mast cell activation (GO:0033003)2.25913724
179protein localization to endosome (GO:0036010)2.24521221
180regulation of antigen processing and presentation (GO:0002577)2.24397453
181negative thymic T cell selection (GO:0045060)2.23567404
182defense response to protozoan (GO:0042832)2.23278720
183negative regulation of cell size (GO:0045792)2.23274983
184leukocyte aggregation (GO:0070486)2.23220641
185regulation of ARF GTPase activity (GO:0032312)2.20662644
186negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.19914356
187positive thymic T cell selection (GO:0045059)2.18076188
188Arp2/3 complex-mediated actin nucleation (GO:0034314)2.17828841
189regulation of defense response to virus by virus (GO:0050690)2.16982798
190response to protozoan (GO:0001562)2.16403043
191positive regulation of antigen processing and presentation (GO:0002579)2.15220609
192positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.14227048
193peptide catabolic process (GO:0043171)2.14173060
194myeloid cell activation involved in immune response (GO:0002275)2.14113001
195tumor necrosis factor-mediated signaling pathway (GO:0033209)2.13123328
196positive regulation of cellular amide metabolic process (GO:0034250)2.13093483
197regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.12903981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.83425335
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.03705431
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.22130973
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.50327208
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29198187
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.08715011
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.99129873
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.64301596
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.01936949
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89031331
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.75343034
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40112658
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36308400
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.22744583
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.19196043
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14873525
17KDM2B_26808549_Chip-Seq_DND41_Human2.14638619
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09975115
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09081186
20VDR_24763502_ChIP-Seq_THP-1_Human2.05647525
21TCF7_22412390_ChIP-Seq_EML_Mouse2.00940713
22RACK7_27058665_Chip-Seq_MCF-7_Human1.99151818
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94496409
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89796487
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89187284
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83065275
27GATA1_22025678_ChIP-Seq_K562_Human1.83038620
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78178980
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70513034
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.69948056
31MAF_26560356_Chip-Seq_TH2_Human1.67671738
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67064351
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64084151
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.62643833
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59559189
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58975083
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58302008
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54845336
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54765684
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.53121903
41LXR_22292898_ChIP-Seq_THP-1_Human1.49228630
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45641454
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45140842
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43702667
45KDM2B_26808549_Chip-Seq_K562_Human1.38993739
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38438236
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36831654
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36749625
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30345583
50CREB1_26743006_Chip-Seq_LNCaP_Human1.28700344
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27847700
52SA1_27219007_Chip-Seq_Bcells_Human1.26942226
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26266783
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.26118122
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23878157
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23690909
57SCL_19346495_ChIP-Seq_HPC-7_Human1.23229539
58RUNX_20019798_ChIP-Seq_JUKART_Human1.23078797
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22526051
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22290692
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.21471152
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20133453
63CTCF_27219007_Chip-Seq_Bcells_Human1.18878108
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18309488
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.18020522
66* SPI1_23547873_ChIP-Seq_NB4_Human1.17371086
67PHF8_20622854_ChIP-Seq_HELA_Human1.16838563
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.16073350
69HTT_18923047_ChIP-ChIP_STHdh_Human1.15669643
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15492009
71E2F1_20622854_ChIP-Seq_HELA_Human1.13482878
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12995315
73CTCF_21964334_Chip-Seq_Bcells_Human1.12650485
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.11890708
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11865161
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11605758
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11207555
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10538084
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10304506
80MYC_22102868_ChIP-Seq_BL_Human1.09656662
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.08843542
82TP63_22573176_ChIP-Seq_HFKS_Human1.08643658
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07524282
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07254803
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07114160
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06278247
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06246496
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.05789204
89NCOR1_26117541_ChIP-Seq_K562_Human1.05204128
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03773614
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03288799
92BCL6_27268052_Chip-Seq_Bcells_Human1.03210798
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02879440
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.02255633
95GATA1_19941826_ChIP-Seq_K562_Human0.97673517
96IRF8_27001747_Chip-Seq_BMDM_Mouse0.97211894
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96421334
98CLOCK_20551151_ChIP-Seq_293T_Human0.96385719
99REST_21632747_ChIP-Seq_MESCs_Mouse0.96107939
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95352307
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94896851
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93840773
103BCOR_27268052_Chip-Seq_Bcells_Human0.93327349
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92576029
105GATA2_19941826_ChIP-Seq_K562_Human0.88913122
106HNF4A_19822575_ChIP-Seq_HepG2_Human0.88820933
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86775701
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83851652
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81691647
110DROSHA_22980978_ChIP-Seq_HELA_Human0.81064552
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81010460
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80714961
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80698774
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79917003
115TAF15_26573619_Chip-Seq_HEK293_Human0.79086717
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77333274
117SPI1_23127762_ChIP-Seq_K562_Human0.76918796
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76518041
119MAF_26560356_Chip-Seq_TH1_Human0.75833938
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.75221315
121MYC_19915707_ChIP-ChIP_AK7_Human0.74660884
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74543161
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.74432734
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74430573
125UTX_26944678_Chip-Seq_JUKART_Human0.73446542
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72736098
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72639461
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72505209
129P68_20966046_ChIP-Seq_HELA_Human0.72416165
130EGR1_19032775_ChIP-ChIP_M12_Human0.71431623
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.71255176
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.70588049
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70539141
134VDR_21846776_ChIP-Seq_THP-1_Human0.70243570
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70202024
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.69839903
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.69723593
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69622418
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69153115
140GATA3_27048872_Chip-Seq_THYMUS_Human0.69029283
141SMC4_20622854_ChIP-Seq_HELA_Human0.68711518
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.67476604
143GATA3_26560356_Chip-Seq_TH2_Human0.66387286
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65757007
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65718959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.28854271
2MP0005360_urolithiasis5.81286088
3MP0005365_abnormal_bile_salt4.97026127
4MP0005085_abnormal_gallbladder_physiolo4.82387159
5MP0008875_abnormal_xenobiotic_pharmacok4.05445375
6MP0010329_abnormal_lipoprotein_level3.17012338
7MP0009840_abnormal_foam_cell2.79384682
8MP0003806_abnormal_nucleotide_metabolis2.73335280
9MP0003252_abnormal_bile_duct2.70104193
10MP0005083_abnormal_biliary_tract2.45387808
11MP0003191_abnormal_cellular_cholesterol2.35835913
12MP0005332_abnormal_amino_acid2.27625971
13MP0001666_abnormal_nutrient_absorption2.16666012
14MP0003195_calcinosis2.09000269
15MP0010155_abnormal_intestine_physiology2.08266044
16MP0002822_catalepsy2.08253707
17MP0002148_abnormal_hypersensitivity_rea2.03176627
18MP0009278_abnormal_bone_marrow2.01227501
19MP0002118_abnormal_lipid_homeostasis1.90273499
20MP0005584_abnormal_enzyme/coenzyme_acti1.89574424
21MP0008004_abnormal_stomach_pH1.85396428
22MP0000609_abnormal_liver_physiology1.85051732
23MP0008260_abnormal_autophagy1.77258067
24MP0009333_abnormal_splenocyte_physiolog1.74756342
25MP0000604_amyloidosis1.71865905
26MP0002452_abnormal_antigen_presenting1.69521773
27MP0002420_abnormal_adaptive_immunity1.67927468
28MP0001819_abnormal_immune_cell1.67584847
29MP0005397_hematopoietic_system_phenotyp1.66184136
30MP0001545_abnormal_hematopoietic_system1.66184136
31MP0003300_gastrointestinal_ulcer1.65710424
32MP0003656_abnormal_erythrocyte_physiolo1.65496705
33MP0003329_amyloid_beta_deposits1.64250273
34MP0004859_abnormal_synaptic_plasticity1.63064688
35MP0002254_reproductive_system_inflammat1.60698652
36MP0005319_abnormal_enzyme/_coenzyme1.59881829
37MP0004947_skin_inflammation1.58592410
38MP0000465_gastrointestinal_hemorrhage1.56398843
39MP0004858_abnormal_nervous_system1.55394302
40MP0001764_abnormal_homeostasis1.54305420
41MP0004510_myositis1.48785099
42MP0001873_stomach_inflammation1.47479060
43MP0001849_ear_inflammation1.40948518
44MP0003436_decreased_susceptibility_to1.40500299
45MP0002998_abnormal_bone_remodeling1.39723211
46MP0002132_abnormal_respiratory_system1.38903777
47MP0002837_dystrophic_cardiac_calcinosis1.38604202
48MP0004019_abnormal_vitamin_homeostasis1.38006957
49MP0003866_abnormal_defecation1.37860071
50MP0004381_abnormal_hair_follicle1.37477874
51MP0004264_abnormal_extraembryonic_tissu1.36817115
52MP0000716_abnormal_immune_system1.35051119
53MP0003868_abnormal_feces_composition1.33833292
54MP0002405_respiratory_system_inflammati1.33684162
55MP0002398_abnormal_bone_marrow1.29082445
56MP0000678_abnormal_parathyroid_gland1.26122425
57MP0005535_abnormal_body_temperature1.24836850
58MP0006036_abnormal_mitochondrial_physio1.24817484
59MP0005464_abnormal_platelet_physiology1.22265340
60MP0002909_abnormal_adrenal_gland1.20955832
61MP0003172_abnormal_lysosome_physiology1.20688956
62MP0009785_altered_susceptibility_to1.19408674
63MP0003183_abnormal_peptide_metabolism1.16257126
64MP0005451_abnormal_body_composition1.16216652
65MP0003075_altered_response_to1.14331487
66MP0000858_altered_metastatic_potential1.13942515
67MP0009643_abnormal_urine_homeostasis1.12700582
68MP0008469_abnormal_protein_level1.12145516
69MP0004130_abnormal_muscle_cell1.11755740
70MP0002429_abnormal_blood_cell1.09873667
71MP0009697_abnormal_copulation1.09698261
72MP0002078_abnormal_glucose_homeostasis1.09660486
73MP0002722_abnormal_immune_system1.09487815
74MP0002876_abnormal_thyroid_physiology1.08384943
75MP0009764_decreased_sensitivity_to1.07535513
76MP0003724_increased_susceptibility_to1.06638231
77MP0005058_abnormal_lysosome_morphology1.05548704
78MP0003279_aneurysm1.05062215
79MP0003635_abnormal_synaptic_transmissio1.03506581
80MP0005636_abnormal_mineral_homeostasis1.03117668
81MP0008874_decreased_physiological_sensi1.02490654
82MP0000689_abnormal_spleen_morphology1.02323103
83MP0001835_abnormal_antigen_presentation1.01653526
84MP0005310_abnormal_salivary_gland1.01455866
85MP0002653_abnormal_ependyma_morphology0.99558592
86MP0000598_abnormal_liver_morphology0.99068020
87MP0009642_abnormal_blood_homeostasis0.97610036
88MP0000703_abnormal_thymus_morphology0.96642015
89MP0005646_abnormal_pituitary_gland0.96329977
90MP0002933_joint_inflammation0.94625370
91MP0002138_abnormal_hepatobiliary_system0.94486228
92MP0005448_abnormal_energy_balance0.93081677
93MP0006035_abnormal_mitochondrial_morpho0.93018310
94MP0006082_CNS_inflammation0.92522053
95MP0005166_decreased_susceptibility_to0.91155087
96MP0005025_abnormal_response_to0.90602538
97MP0002419_abnormal_innate_immunity0.90191347
98MP0002064_seizures0.90124193
99MP0005409_darkened_coat_color0.89717655
100MP0009763_increased_sensitivity_to0.89605242
101MP0003453_abnormal_keratinocyte_physiol0.89453544
102MP0000343_altered_response_to0.88780782
103MP0000013_abnormal_adipose_tissue0.88752043
104MP0003633_abnormal_nervous_system0.87336748
105MP0005075_abnormal_melanosome_morpholog0.86474892
106MP0001663_abnormal_digestive_system0.85962813
107MP0001986_abnormal_taste_sensitivity0.85209902
108MP0000490_abnormal_crypts_of0.84583283
109MP0001845_abnormal_inflammatory_respons0.83169542
110MP0005390_skeleton_phenotype0.82611688
111MP0002063_abnormal_learning/memory/cond0.81953441
112MP0003690_abnormal_glial_cell0.81369359
113MP0005167_abnormal_blood-brain_barrier0.80722720
114MP0003186_abnormal_redox_activity0.80497454
115MP0003879_abnormal_hair_cell0.80103497
116MP0009745_abnormal_behavioral_response0.79794263
117MP0000685_abnormal_immune_system0.79367731
118MP0005084_abnormal_gallbladder_morpholo0.78680138
119MP0001664_abnormal_digestion0.78632474
120MP0000639_abnormal_adrenal_gland0.78528146
121MP0005671_abnormal_response_to0.78475056
122MP0003303_peritoneal_inflammation0.77917247
123MP0003705_abnormal_hypodermis_morpholog0.77199330
124MP0003795_abnormal_bone_structure0.76402484
125MP0003638_abnormal_response/metabolism_0.75593185
126MP0000015_abnormal_ear_pigmentation0.74300427
127MP0008872_abnormal_physiological_respon0.73505206
128MP0003011_delayed_dark_adaptation0.73379817
129MP0005376_homeostasis/metabolism_phenot0.73336830
130MP0001790_abnormal_immune_system0.71534023
131MP0005387_immune_system_phenotype0.71534023
132MP0005666_abnormal_adipose_tissue0.71370260
133MP0005220_abnormal_exocrine_pancreas0.70771233
134MP0001853_heart_inflammation0.69598523
135MP0001984_abnormal_olfaction0.69493580
136MP0008961_abnormal_basal_metabolism0.68197824
137MP0009046_muscle_twitch0.66885857
138MP0001800_abnormal_humoral_immune0.66377435
139MP0002572_abnormal_emotion/affect_behav0.66331501
140MP0000249_abnormal_blood_vessel0.65741870
141MP0001756_abnormal_urination0.63921338
142MP0005000_abnormal_immune_tolerance0.63821623
143MP0003953_abnormal_hormone_level0.63584363
144MP0001501_abnormal_sleep_pattern0.62743210
145MP0005334_abnormal_fat_pad0.62179518
146MP0003763_abnormal_thymus_physiology0.61676850
147MP0002971_abnormal_brown_adipose0.61497211
148MP0001533_abnormal_skeleton_physiology0.61386438
149MP0002723_abnormal_immune_serum0.61112726
150MP0009780_abnormal_chondrocyte_physiolo0.60475266
151MP0002090_abnormal_vision0.60266312
152MP0000230_abnormal_systemic_arterial0.59051861
153MP0005670_abnormal_white_adipose0.58916360

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.50495910
2Deep venous thrombosis (HP:0002625)5.40983716
3Prolonged partial thromboplastin time (HP:0003645)4.62826869
4Hypobetalipoproteinemia (HP:0003563)4.54035773
5Intrahepatic cholestasis (HP:0001406)4.52589720
6Xanthomatosis (HP:0000991)4.51394587
7Complement deficiency (HP:0004431)4.29048447
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.27517362
9Hyperlipoproteinemia (HP:0010980)4.18047487
10Increased cerebral lipofuscin (HP:0011813)3.92539788
11Eczematoid dermatitis (HP:0000976)3.81536224
12Ketosis (HP:0001946)3.81001637
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.75480372
14Purpura (HP:0000979)3.68837409
15Hyperammonemia (HP:0001987)3.62433978
16Abnormality of macrophages (HP:0004311)3.56245816
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55796419
18Abnormality of the common coagulation pathway (HP:0010990)3.54746075
19Joint hemorrhage (HP:0005261)3.51890902
20Petechiae (HP:0000967)3.51187333
21Stomatitis (HP:0010280)3.42278166
22Myositis (HP:0100614)3.37879764
23Abnormality of fatty-acid metabolism (HP:0004359)3.35380980
24Dysostosis multiplex (HP:0000943)3.34720287
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.32256689
26Loss of speech (HP:0002371)3.25332391
27Hypolipoproteinemia (HP:0010981)3.22723561
28Hyperbilirubinemia (HP:0002904)3.19334714
29Prolonged bleeding time (HP:0003010)3.17792519
30Systemic lupus erythematosus (HP:0002725)3.16726829
31Abnormality of the intrinsic pathway (HP:0010989)3.16476626
32Hypoglycemic coma (HP:0001325)3.13256487
33Abnormality of glycolipid metabolism (HP:0010969)3.12467376
34Abnormality of liposaccharide metabolism (HP:0010968)3.12467376
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.12467376
36Abnormality of complement system (HP:0005339)3.11995058
37Orchitis (HP:0100796)3.11344212
38Elevated erythrocyte sedimentation rate (HP:0003565)3.07630286
39Ketoacidosis (HP:0001993)3.05652769
40Conjugated hyperbilirubinemia (HP:0002908)2.96868352
41Hemorrhage of the eye (HP:0011885)2.94463703
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.93323714
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92998209
44Recurrent gram-negative bacterial infections (HP:0005420)2.91789374
45Recurrent abscess formation (HP:0002722)2.90328246
46Epidermoid cyst (HP:0200040)2.87560499
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86574071
48Abnormality of polysaccharide metabolism (HP:0011012)2.86574071
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86574071
50Fat malabsorption (HP:0002630)2.85728892
51Gout (HP:0001997)2.80038273
52Cholecystitis (HP:0001082)2.74000244
53Abnormal gallbladder physiology (HP:0012438)2.74000244
54Hyperglycinemia (HP:0002154)2.73018610
55Recurrent bacterial skin infections (HP:0005406)2.70894059
56Urinary glycosaminoglycan excretion (HP:0003541)2.69518966
57Mucopolysacchariduria (HP:0008155)2.69518966
58Hypoalphalipoproteinemia (HP:0003233)2.68822032
59Optic neuritis (HP:0100653)2.68090743
60Retrobulbar optic neuritis (HP:0100654)2.68090743
61Abnormality of methionine metabolism (HP:0010901)2.60768187
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60110166
63Abnormal gallbladder morphology (HP:0012437)2.59778684
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59152163
65Cholelithiasis (HP:0001081)2.58940091
66Recurrent fungal infections (HP:0002841)2.57949999
67Mitral stenosis (HP:0001718)2.55995218
68Obstructive lung disease (HP:0006536)2.53665333
69Chronic obstructive pulmonary disease (HP:0006510)2.53665333
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.53332114
71Abnormality of glycine metabolism (HP:0010895)2.48846307
72Abnormality of serine family amino acid metabolism (HP:0010894)2.48846307
73Sensorimotor neuropathy (HP:0007141)2.47483615
74Vacuolated lymphocytes (HP:0001922)2.46731197
75Thin bony cortex (HP:0002753)2.46531021
76Hypercholesterolemia (HP:0003124)2.46305949
77Metabolic acidosis (HP:0001942)2.45256423
78Hyperglycinuria (HP:0003108)2.44634461
79Abnormality of purine metabolism (HP:0004352)2.43710620
80Delayed CNS myelination (HP:0002188)2.40251834
81Generalized aminoaciduria (HP:0002909)2.39835553
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35822422
83Dicarboxylic aciduria (HP:0003215)2.35822422
84Thoracic kyphosis (HP:0002942)2.34564861
85Abnormality of nucleobase metabolism (HP:0010932)2.34365361
86Bulbar palsy (HP:0001283)2.32197420
87Glomerulonephritis (HP:0000099)2.28012555
88Gastrointestinal infarctions (HP:0005244)2.27036492
89Mediastinal lymphadenopathy (HP:0100721)2.26293536
90Vasculitis (HP:0002633)2.25864378
91Gingivitis (HP:0000230)2.25620168
92Distal lower limb muscle weakness (HP:0009053)2.25603198
93Increased serum ferritin (HP:0003281)2.24922663
94Gastrointestinal inflammation (HP:0004386)2.23832321
95Hypoglycemic seizures (HP:0002173)2.22880948
96J-shaped sella turcica (HP:0002680)2.22344516
97Axonal loss (HP:0003447)2.21431437
98Abnormality of the thoracic spine (HP:0100711)2.21313017
99Malnutrition (HP:0004395)2.20749523
100Steatorrhea (HP:0002570)2.19966823
101Cellulitis (HP:0100658)2.19351792
102Neonatal onset (HP:0003623)2.19097724
103Hyperventilation (HP:0002883)2.17734825
104Pustule (HP:0200039)2.16485739
105Late onset (HP:0003584)2.15852995
106Abnormality of pyrimidine metabolism (HP:0004353)2.15674843
107Meningitis (HP:0001287)2.15383258
108Death in childhood (HP:0003819)2.15166633
109Increased IgE level (HP:0003212)2.14360828
110Abnormality of the gallbladder (HP:0005264)2.10424147
111Gingival bleeding (HP:0000225)2.10103728
112Clumsiness (HP:0002312)2.08307253
113Spastic diplegia (HP:0001264)2.08274829
114Easy fatigability (HP:0003388)2.08041910
115Brushfield spots (HP:0001088)2.07325153
116Myopathic facies (HP:0002058)2.07144560
117Inflammation of the large intestine (HP:0002037)2.06757805
118Pulmonary embolism (HP:0002204)2.06635361
119Granulocytopenia (HP:0001913)2.06469043
120Thrombophlebitis (HP:0004418)2.06439846
121Recurrent skin infections (HP:0001581)2.06295711
122Stridor (HP:0010307)2.06115436
123Gastrointestinal stroma tumor (HP:0100723)2.03036320
124Abnormality of the columella (HP:0009929)2.01781879
125Spontaneous abortion (HP:0005268)2.01395248
126Lethargy (HP:0001254)2.00595795
127Hepatocellular carcinoma (HP:0001402)2.00494506
128Hypophosphatemia (HP:0002148)1.99698333
129Status epilepticus (HP:0002133)1.99651926
130Cerebral hemorrhage (HP:0001342)1.99258246
131Irritability (HP:0000737)1.98104307
132Disinhibition (HP:0000734)1.97182226
133Obstructive sleep apnea (HP:0002870)1.96330247
134Opisthotonus (HP:0002179)1.95666343
135Epistaxis (HP:0000421)1.94342028
136Recurrent cutaneous fungal infections (HP:0011370)1.94320085
137Chronic mucocutaneous candidiasis (HP:0002728)1.94320085
138Keratoconjunctivitis sicca (HP:0001097)1.94225703
139Hepatosplenomegaly (HP:0001433)1.93347559
140Ankle clonus (HP:0011448)1.91912231
141Keratoconjunctivitis (HP:0001096)1.91382172
142Skin nodule (HP:0200036)1.91140002
143Colitis (HP:0002583)1.90963659
144Abnormality of the nasal mucosa (HP:0000433)1.90306170
145Spontaneous hematomas (HP:0007420)1.89356136
146Epiphyseal stippling (HP:0010655)1.88185310
147Oligomenorrhea (HP:0000876)1.87135663
148Neuronal loss in central nervous system (HP:0002529)1.86738903
149Increased IgM level (HP:0003496)1.86175215
150Pancreatitis (HP:0001733)1.86051216
151Neuroendocrine neoplasm (HP:0100634)1.86038363
152Vomiting (HP:0002013)1.85516717
153Abnormality of serum amino acid levels (HP:0003112)1.85206540
154Emphysema (HP:0002097)1.84341589
155Flat acetabular roof (HP:0003180)1.84179145
156Craniofacial dystonia (HP:0012179)1.84097665
157Vertebral compression fractures (HP:0002953)1.83225870
158Abnormality of the costochondral junction (HP:0000919)1.82728294
159Polycythemia (HP:0001901)1.82617828
160Mutism (HP:0002300)1.81957718
161Hypertriglyceridemia (HP:0002155)1.81757235
162Cerebral edema (HP:0002181)1.81162778
163Encephalitis (HP:0002383)1.80145705
164Exercise-induced myalgia (HP:0003738)1.79898044
165Abnormality of iron homeostasis (HP:0011031)1.79629145
166Acne (HP:0001061)1.79541069
167Hemoptysis (HP:0002105)1.79365141
168Slow saccadic eye movements (HP:0000514)1.78891300
169Conjunctival hamartoma (HP:0100780)1.78870542
170Myocardial infarction (HP:0001658)1.77702589
171Focal dystonia (HP:0004373)1.77490784
172Visual hallucinations (HP:0002367)1.77140568
173Amyloidosis (HP:0011034)1.75334564
174Torticollis (HP:0000473)1.74409639
175Abnormality of endocrine pancreas physiology (HP:0012093)1.74143946
176Abnormality of the pancreatic islet cells (HP:0006476)1.74143946
177Acute hepatic failure (HP:0006554)1.73664242
178Pheochromocytoma (HP:0002666)1.72458187
179Joint swelling (HP:0001386)1.72023618
180Menorrhagia (HP:0000132)1.71781259
181Hypoplasia of the thymus (HP:0000778)1.71146318
182Hepatic necrosis (HP:0002605)1.68019576
183Ragged-red muscle fibers (HP:0003200)1.66927487
184Myokymia (HP:0002411)1.63737081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.87834696
2ERN13.51622672
3MAP3K122.69887698
4MAP2K42.63768861
5MAP4K12.58127850
6PRPF4B2.43878511
7TRIB32.38603630
8DAPK22.17902172
9FGFR42.00516664
10ZAP701.94084677
11CAMKK11.93886154
12TAOK31.92555572
13PKN21.89792578
14DAPK11.87313296
15NME21.86849655
16IRAK31.83691366
17GRK61.78963655
18SMG11.75404070
19MARK31.71858024
20TAOK21.69885779
21TYK21.69741059
22TXK1.66553287
23MAP2K31.62720288
24MAP3K31.57663737
25EPHA41.55298062
26CAMKK21.53431160
27MAP3K41.49914036
28INSRR1.49718105
29SIK11.49091976
30EPHB11.40201410
31FES1.39001468
32MAP3K141.37685973
33CDK191.37157787
34TBK11.32646452
35MAP2K71.32300573
36PRKCH1.30310122
37MAPKAPK31.28718976
38PRKD21.28308685
39JAK11.27892142
40FLT31.24147911
41EEF2K1.23311251
42MINK11.20654084
43CDC42BPA1.18753558
44PIM21.18313087
45SIK31.17109930
46ICK1.16483677
47SYK1.14273368
48TESK11.13379368
49KDR1.12296066
50MAP3K61.11136845
51BTK1.06999215
52PDK31.04660005
53PDK41.04660005
54IRAK21.04565580
55MAP2K61.03758984
56KIT1.03417546
57MARK21.02543396
58TAOK11.01920015
59MAP3K71.00329656
60IKBKB1.00005214
61IKBKE0.99843579
62MAPK110.99345190
63MAPK120.99247712
64HIPK20.98358667
65JAK20.97808381
66ITK0.97251089
67STK380.96493198
68MAP3K110.96472989
69TGFBR20.96395067
70KSR20.92353747
71SGK30.91236403
72NTRK30.88403407
73MATK0.88352776
74EPHA20.88075926
75PINK10.88055944
76CDK120.85515552
77MAP3K130.85418703
78MAPK40.84409034
79RIPK40.84274335
80MUSK0.82205347
81RIPK10.79947477
82SGK20.79808189
83FGR0.79804452
84ARAF0.79527330
85MAP3K90.78811469
86RPS6KL10.77356221
87RPS6KC10.77356221
88BLK0.76529924
89RET0.75961887
90TESK20.75709568
91CSF1R0.74463433
92PRKG20.74284683
93MAP3K10.74221342
94CAMK40.72633396
95IRAK40.72622865
96MAP2K20.72186193
97SIK20.69201558
98PRKCG0.67956367
99DDR20.67538445
100PDK10.65981902
101CHUK0.63867433
102BMX0.63120485
103MAP3K100.62925304
104LRRK20.60514764
105SGK4940.60442784
106SGK2230.60442784
107IRAK10.59940601
108RPS6KA60.58958836
109PDPK10.57780022
110TNK20.56788422
111TYRO30.56670646
112MAPKAPK20.55254192
113NEK10.55163130
114RPS6KA20.54998048
115PTK60.54031691
116LYN0.52307298
117CDK50.52053561
118TGFBR10.51786629
119MTOR0.51496090
120LCK0.51317449
121ADRBK20.50879352
122JAK30.50686759
123PRKCZ0.50072516
124MAPK70.49654483
125PASK0.49533581
126MYLK0.49528159
127TEC0.49499290
128TIE10.47413517
129CCNB10.47244816
130CSK0.46182457
131DYRK1B0.45524209
132PRKACG0.45007140
133ERBB40.44756718
134PRKCQ0.44421080
135PTK2B0.44005780
136HCK0.43371956
137NTRK10.42574902
138MAP3K50.42210236
139TTN0.42023287
140RPS6KA10.40338916
141MARK10.39853598
142PRKD30.39759249
143CAMK10.39271793
144BRAF0.39249744
145FYN0.38825335

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.08741889
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.01567107
3Nitrogen metabolism_Homo sapiens_hsa009103.04377812
4Arginine biosynthesis_Homo sapiens_hsa002202.84703880
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81459875
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69551074
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65894234
8Fatty acid degradation_Homo sapiens_hsa000712.38240595
9Butanoate metabolism_Homo sapiens_hsa006502.31093606
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30484359
11Tryptophan metabolism_Homo sapiens_hsa003802.30230475
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22221506
13Complement and coagulation cascades_Homo sapiens_hsa046102.21664658
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07822774
15Osteoclast differentiation_Homo sapiens_hsa043802.05162614
16Propanoate metabolism_Homo sapiens_hsa006402.02107724
17Peroxisome_Homo sapiens_hsa041461.95602602
18Acute myeloid leukemia_Homo sapiens_hsa052211.89540031
19Pyruvate metabolism_Homo sapiens_hsa006201.85159582
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82754705
21Staphylococcus aureus infection_Homo sapiens_hsa051501.77242835
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76154371
23Fatty acid metabolism_Homo sapiens_hsa012121.75275257
24B cell receptor signaling pathway_Homo sapiens_hsa046621.73102067
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70798285
26Leishmaniasis_Homo sapiens_hsa051401.62844069
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62794107
28PPAR signaling pathway_Homo sapiens_hsa033201.62512860
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61643848
30beta-Alanine metabolism_Homo sapiens_hsa004101.55862737
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.53177208
32Histidine metabolism_Homo sapiens_hsa003401.50034497
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47413562
34Caffeine metabolism_Homo sapiens_hsa002321.47208727
35Carbon metabolism_Homo sapiens_hsa012001.47198504
36Tuberculosis_Homo sapiens_hsa051521.45019238
37Bile secretion_Homo sapiens_hsa049761.43598474
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43126360
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.41707923
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41184147
41Allograft rejection_Homo sapiens_hsa053301.34846253
42Biosynthesis of amino acids_Homo sapiens_hsa012301.32053241
43Starch and sucrose metabolism_Homo sapiens_hsa005001.32040594
44Graft-versus-host disease_Homo sapiens_hsa053321.31783946
45TNF signaling pathway_Homo sapiens_hsa046681.31458234
46T cell receptor signaling pathway_Homo sapiens_hsa046601.31352754
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30801888
48Chemical carcinogenesis_Homo sapiens_hsa052041.30381386
49Hepatitis C_Homo sapiens_hsa051601.30014063
50Phenylalanine metabolism_Homo sapiens_hsa003601.29844415
51Pertussis_Homo sapiens_hsa051331.27794672
52Sulfur metabolism_Homo sapiens_hsa009201.26428024
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23693922
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.23482713
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23244658
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22987822
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.21885892
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19135997
59ABC transporters_Homo sapiens_hsa020101.16372764
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15277595
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14835844
62Autoimmune thyroid disease_Homo sapiens_hsa053201.11432693
63Fatty acid elongation_Homo sapiens_hsa000621.08650224
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08466019
65Malaria_Homo sapiens_hsa051441.08090432
66Chemokine signaling pathway_Homo sapiens_hsa040621.04098756
67Influenza A_Homo sapiens_hsa051641.02120259
68Apoptosis_Homo sapiens_hsa042101.02051841
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01856452
70Hematopoietic cell lineage_Homo sapiens_hsa046401.01614448
71Intestinal immune network for IgA production_Homo sapiens_hsa046721.00622854
72Herpes simplex infection_Homo sapiens_hsa051680.98547106
73Toxoplasmosis_Homo sapiens_hsa051450.98038353
74Notch signaling pathway_Homo sapiens_hsa043300.96764035
75Retinol metabolism_Homo sapiens_hsa008300.96453391
76Asthma_Homo sapiens_hsa053100.96412459
77VEGF signaling pathway_Homo sapiens_hsa043700.96295385
78Platelet activation_Homo sapiens_hsa046110.95743333
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94499707
80Selenocompound metabolism_Homo sapiens_hsa004500.94058770
81Tyrosine metabolism_Homo sapiens_hsa003500.93512923
82Synaptic vesicle cycle_Homo sapiens_hsa047210.91628245
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.91598436
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.91179404
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.89960693
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89569828
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.89125499
88Phagosome_Homo sapiens_hsa041450.87995304
89Measles_Homo sapiens_hsa051620.87416947
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.86311223
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86296414
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86146004
93Hepatitis B_Homo sapiens_hsa051610.85798566
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.85487986
95Fat digestion and absorption_Homo sapiens_hsa049750.83234887
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82385030
97Sulfur relay system_Homo sapiens_hsa041220.81989236
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79652225
99Prolactin signaling pathway_Homo sapiens_hsa049170.79187023
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.78775638
101Pentose phosphate pathway_Homo sapiens_hsa000300.78443076
102Endocytosis_Homo sapiens_hsa041440.77363636
103Non-small cell lung cancer_Homo sapiens_hsa052230.74832062
104Antigen processing and presentation_Homo sapiens_hsa046120.72516756
105Rheumatoid arthritis_Homo sapiens_hsa053230.72158787
106Type I diabetes mellitus_Homo sapiens_hsa049400.70555371
107Chronic myeloid leukemia_Homo sapiens_hsa052200.69710683
108African trypanosomiasis_Homo sapiens_hsa051430.68661467
109Viral myocarditis_Homo sapiens_hsa054160.68506353
110Shigellosis_Homo sapiens_hsa051310.67970952
111Glycerolipid metabolism_Homo sapiens_hsa005610.67354716
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66276333
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64195011
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63609487
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62934449
116mTOR signaling pathway_Homo sapiens_hsa041500.62404336
117Arachidonic acid metabolism_Homo sapiens_hsa005900.61678453
118Salmonella infection_Homo sapiens_hsa051320.61336300
119Amoebiasis_Homo sapiens_hsa051460.61272070
120Fructose and mannose metabolism_Homo sapiens_hsa000510.60579531
121Legionellosis_Homo sapiens_hsa051340.60344562
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58625121
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57924812
124Folate biosynthesis_Homo sapiens_hsa007900.57643827
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56701974
126Galactose metabolism_Homo sapiens_hsa000520.56364139
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55271653
128Arginine and proline metabolism_Homo sapiens_hsa003300.53996193
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.53463468
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51451264
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51278614
132AMPK signaling pathway_Homo sapiens_hsa041520.50820749
133Bladder cancer_Homo sapiens_hsa052190.50009104
134GnRH signaling pathway_Homo sapiens_hsa049120.49918995
135GABAergic synapse_Homo sapiens_hsa047270.49682514
136Sphingolipid metabolism_Homo sapiens_hsa006000.48305390
137Insulin resistance_Homo sapiens_hsa049310.47811278
138Collecting duct acid secretion_Homo sapiens_hsa049660.46721620
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45707521
140Lysine degradation_Homo sapiens_hsa003100.42239585
141Vitamin B6 metabolism_Homo sapiens_hsa007500.40431733
142Prion diseases_Homo sapiens_hsa050200.38717897
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35053285
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.34821254
145Vitamin digestion and absorption_Homo sapiens_hsa049770.33109358
146Glucagon signaling pathway_Homo sapiens_hsa049220.30885128
147Olfactory transduction_Homo sapiens_hsa047400.30231993
148Metabolic pathways_Homo sapiens_hsa011000.30037699
149Insulin secretion_Homo sapiens_hsa049110.29173281
150Steroid biosynthesis_Homo sapiens_hsa001000.28851430
151Type II diabetes mellitus_Homo sapiens_hsa049300.26400005
152Morphine addiction_Homo sapiens_hsa050320.25228794
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22697515
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21339891
155Primary immunodeficiency_Homo sapiens_hsa053400.20387211
156Fatty acid biosynthesis_Homo sapiens_hsa000610.19808498
157Lysosome_Homo sapiens_hsa041420.19641061
158Glutathione metabolism_Homo sapiens_hsa004800.18699208
159Insulin signaling pathway_Homo sapiens_hsa049100.17412772
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.17347836
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15965399
162Nicotine addiction_Homo sapiens_hsa050330.13326271
163Vibrio cholerae infection_Homo sapiens_hsa051100.11777966
164Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11252042
165Dopaminergic synapse_Homo sapiens_hsa047280.11008640
166Regulation of autophagy_Homo sapiens_hsa041400.10608772
167Circadian entrainment_Homo sapiens_hsa047130.10362271
168Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09765367
169Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09672295
170Other glycan degradation_Homo sapiens_hsa005110.07288816
171Cocaine addiction_Homo sapiens_hsa050300.05427588
172N-Glycan biosynthesis_Homo sapiens_hsa005100.04632737

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