NAAA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)7.33594687
2modulation by symbiont of host defense response (GO:0052031)7.33594687
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.33594687
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.33594687
5positive regulation by organism of defense response of other organism involved in symbiotic interact7.33594687
6modulation by symbiont of host immune response (GO:0052553)7.33594687
7microglial cell activation (GO:0001774)6.00547678
8positive regulation of monocyte chemotaxis (GO:0090026)5.41758479
9regulation of interferon-beta biosynthetic process (GO:0045357)5.39907497
10positive regulation of gamma-delta T cell activation (GO:0046645)5.12119406
11macrophage activation involved in immune response (GO:0002281)5.08854823
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.94973405
13negative regulation of cell killing (GO:0031342)4.94973405
14neutrophil activation involved in immune response (GO:0002283)4.87299989
15respiratory burst (GO:0045730)4.86443789
16cellular response to exogenous dsRNA (GO:0071360)4.85245759
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79829990
18response to host immune response (GO:0052572)4.76892097
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.76892097
20positive regulation of cellular amide metabolic process (GO:0034250)4.73411203
21positive regulation of chemokine biosynthetic process (GO:0045080)4.73014704
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70519666
23positive regulation of interferon-alpha production (GO:0032727)4.69122184
24response to peptidoglycan (GO:0032494)4.50865713
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.47578150
26intracellular pH reduction (GO:0051452)4.39453584
27regulation of interferon-alpha production (GO:0032647)4.38539823
28production of molecular mediator involved in inflammatory response (GO:0002532)4.35311598
29immunoglobulin mediated immune response (GO:0016064)4.28872018
30regulation of monocyte chemotaxis (GO:0090025)4.21744255
31response to host (GO:0075136)4.15105723
32response to host defenses (GO:0052200)4.15105723
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.15105723
34macrophage activation (GO:0042116)4.12354940
35pinocytosis (GO:0006907)4.10260810
36regulation of dendritic cell antigen processing and presentation (GO:0002604)4.09937776
37detection of other organism (GO:0098543)4.00112552
38regulation of B cell receptor signaling pathway (GO:0050855)3.98186675
39cellular extravasation (GO:0045123)3.95703076
40detection of bacterium (GO:0016045)3.88366262
41glycosphingolipid catabolic process (GO:0046479)3.86518508
42regulation of gamma-delta T cell activation (GO:0046643)3.84561925
43positive regulation of antigen processing and presentation (GO:0002579)3.81750966
44negative regulation of interleukin-12 production (GO:0032695)3.77311505
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71641487
46cellular response to interferon-beta (GO:0035458)3.67868142
47regulation of chemokine biosynthetic process (GO:0045073)3.65142154
48myeloid cell activation involved in immune response (GO:0002275)3.63044168
49pH reduction (GO:0045851)3.60752425
50sphingolipid catabolic process (GO:0030149)3.59695062
51positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.52978369
52superoxide anion generation (GO:0042554)3.52861157
53regulation of gamma-delta T cell differentiation (GO:0045586)3.52738923
54membrane raft organization (GO:0031579)3.49955764
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.47844628
56neutrophil activation (GO:0042119)3.43598437
57glycolipid catabolic process (GO:0019377)3.42840891
58antigen processing and presentation of endogenous antigen (GO:0019883)3.42719680
59positive thymic T cell selection (GO:0045059)3.42378953
60regulation of phospholipase A2 activity (GO:0032429)3.41602712
61positive regulation of toll-like receptor signaling pathway (GO:0034123)3.41249526
62granulocyte activation (GO:0036230)3.40617925
63detection of external biotic stimulus (GO:0098581)3.37483606
64negative thymic T cell selection (GO:0045060)3.31973822
65positive regulation of macrophage cytokine production (GO:0060907)3.30024242
66positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.27007204
67negative T cell selection (GO:0043383)3.26470754
68positive regulation of interleukin-12 production (GO:0032735)3.26358931
69membrane lipid catabolic process (GO:0046466)3.23871182
70I-kappaB phosphorylation (GO:0007252)3.23183288
71regulation of antigen processing and presentation (GO:0002577)3.21930974
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.21237625
73ceramide catabolic process (GO:0046514)3.18408251
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18026724
75leukocyte aggregation (GO:0070486)3.17655873
76antigen processing and presentation via MHC class Ib (GO:0002475)3.15038409
77oligosaccharide catabolic process (GO:0009313)3.14704355
78hydrogen peroxide biosynthetic process (GO:0050665)3.10676858
79regulation of mast cell activation involved in immune response (GO:0033006)3.09301857
80detection of biotic stimulus (GO:0009595)3.08558679
81regulation of T cell mediated cytotoxicity (GO:0001914)3.08111960
82regulation of T cell tolerance induction (GO:0002664)3.07189240
83negative regulation of T cell mediated immunity (GO:0002710)3.04956568
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.04776275
85regulation of tolerance induction (GO:0002643)3.04442574
86regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03718025
87positive regulation of mast cell activation involved in immune response (GO:0033008)3.02893220
88positive regulation of mast cell degranulation (GO:0043306)3.02893220
89negative regulation of leukocyte mediated immunity (GO:0002704)3.02839276
90response to muramyl dipeptide (GO:0032495)3.01424473
91T cell migration (GO:0072678)3.00710847
92interferon-gamma-mediated signaling pathway (GO:0060333)3.00511550
93positive regulation of interferon-beta production (GO:0032728)2.99291003
94regulation of alpha-beta T cell proliferation (GO:0046640)2.99093403
95T cell selection (GO:0045058)2.99009579
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93996254
97type I interferon signaling pathway (GO:0060337)2.93874842
98cellular response to type I interferon (GO:0071357)2.93874842
99positive regulation of mast cell activation (GO:0033005)2.93260407
100detection of molecule of bacterial origin (GO:0032490)2.93220541
101B cell receptor signaling pathway (GO:0050853)2.93203269
102response to type I interferon (GO:0034340)2.92445282
103phagocytosis, engulfment (GO:0006911)2.92255473
104regulation of leukocyte degranulation (GO:0043300)2.91680984
105regulation of mononuclear cell migration (GO:0071675)2.90526155
106myeloid leukocyte activation (GO:0002274)2.88696781
107tolerance induction (GO:0002507)2.88132028
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.87183425
109leukocyte mediated cytotoxicity (GO:0001909)2.84746237
110positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.83724488
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82879621
112regulation of T-helper 2 cell differentiation (GO:0045628)2.82440385
113positive T cell selection (GO:0043368)2.82177002
114T-helper 1 type immune response (GO:0042088)2.79936407
115dendritic cell chemotaxis (GO:0002407)2.79074850
116regulation of interferon-gamma biosynthetic process (GO:0045072)2.77751699
117regulation of regulatory T cell differentiation (GO:0045589)2.77408001
118T cell costimulation (GO:0031295)2.77141290
119regulation of B cell differentiation (GO:0045577)2.77113342
120regulation of lymphocyte migration (GO:2000401)2.77078479
121cellular response to interleukin-15 (GO:0071350)2.76653179
122dendritic cell migration (GO:0036336)2.76648760
123B cell mediated immunity (GO:0019724)2.75778727
124lymphocyte chemotaxis (GO:0048247)2.75244575
125regulation of mast cell degranulation (GO:0043304)2.74616735
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73720185
127regulation of mast cell activation (GO:0033003)2.73246117
128lymphocyte costimulation (GO:0031294)2.73133552
129natural killer cell mediated immunity (GO:0002228)2.72283851
130natural killer cell mediated cytotoxicity (GO:0042267)2.72283851
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71707300
132positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.71684747
133positive regulation of chemokine production (GO:0032722)2.71562401
134response to interleukin-15 (GO:0070672)2.71543978
135positive regulation of interleukin-6 production (GO:0032755)2.71401193
136positive regulation of tumor necrosis factor production (GO:0032760)2.71063576
137mast cell activation (GO:0045576)2.70812367
138positive regulation of B cell differentiation (GO:0045579)2.70356565
139positive regulation of type 2 immune response (GO:0002830)2.70151588
140negative regulation of mast cell activation (GO:0033004)2.70043431
141response to protozoan (GO:0001562)2.69296009
142reactive oxygen species biosynthetic process (GO:1903409)2.67202472
143positive regulation of T cell migration (GO:2000406)2.66703813
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65689478
145leukocyte degranulation (GO:0043299)2.65394621
146regulation of cellular extravasation (GO:0002691)2.65101467
147defense response to protozoan (GO:0042832)2.64779562
148positive regulation of leukocyte degranulation (GO:0043302)2.64327612
149cellular response to interferon-gamma (GO:0071346)2.64251636
150phagocytosis, recognition (GO:0006910)2.63411192
151eosinophil chemotaxis (GO:0048245)2.63322756
152thymic T cell selection (GO:0045061)2.62605347
153positive regulation of interleukin-17 production (GO:0032740)2.62578207
154NIK/NF-kappaB signaling (GO:0038061)2.62563832
155L-amino acid import (GO:0043092)2.62308545
156positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61819974
157antigen receptor-mediated signaling pathway (GO:0050851)2.59400070
158regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59263184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.74462022
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.58241096
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.94660814
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.34976281
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.55557958
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45378862
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.38306480
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10620850
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98964275
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98509112
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70838250
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39380432
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33917406
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23759988
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16672647
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12735838
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10564456
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06897086
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99355674
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99087818
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95304588
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89733979
23VDR_24787735_ChIP-Seq_THP-1_Human1.89125988
24VDR_21846776_ChIP-Seq_THP-1_Human1.87007927
25RUNX_20019798_ChIP-Seq_JUKART_Human1.80610974
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80038723
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78525754
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75784611
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73119157
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71066098
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67900116
32UTX_26944678_Chip-Seq_JUKART_Human1.64773663
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57935690
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55522901
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54909712
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52392238
37* SPI1_23127762_ChIP-Seq_K562_Human1.50298050
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47787155
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.43278841
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42846047
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42846047
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41134669
43PU_27001747_Chip-Seq_BMDM_Mouse1.41034148
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40996829
45SPI1_23547873_ChIP-Seq_NB4_Human1.40410344
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35768173
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33523084
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32555666
49* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31405610
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30407499
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29114779
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28805773
53MAF_26560356_Chip-Seq_TH2_Human1.26614022
54BCL6_27268052_Chip-Seq_Bcells_Human1.25177281
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25171492
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21105138
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21062145
58* MYB_26560356_Chip-Seq_TH2_Human1.17979484
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17496344
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16847300
61MYC_22102868_ChIP-Seq_BL_Human1.13763514
62* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11364048
63CJUN_26792858_Chip-Seq_BT549_Human1.07214041
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.07122942
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06828452
66VDR_24763502_ChIP-Seq_THP-1_Human1.06563755
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05750678
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05215864
69GATA1_19941826_ChIP-Seq_K562_Human1.04822369
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04327712
71STAT1_20625510_ChIP-Seq_HELA_Human1.03539390
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01435740
73* BCOR_27268052_Chip-Seq_Bcells_Human1.01290023
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01115592
75GATA3_27048872_Chip-Seq_THYMUS_Human1.00910684
76TCF7_22412390_ChIP-Seq_EML_Mouse1.00900448
77AR_21572438_ChIP-Seq_LNCaP_Human0.99990259
78RXR_22158963_ChIP-Seq_LIVER_Mouse0.99467058
79TP53_18474530_ChIP-ChIP_U2OS_Human0.98740142
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98432961
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.98277575
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97318396
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97005165
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96513985
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.95396583
86RXR_22108803_ChIP-Seq_LS180_Human0.94165718
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94038767
88P300_27268052_Chip-Seq_Bcells_Human0.90929592
89LXR_22158963_ChIP-Seq_LIVER_Mouse0.90155780
90SOX2_20726797_ChIP-Seq_SW620_Human0.89930516
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89706271
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89504421
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89323563
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87529671
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85882410
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85429063
97MAF_26560356_Chip-Seq_TH1_Human0.85238470
98EGR1_19032775_ChIP-ChIP_M12_Human0.85187805
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84691554
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84186945
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84066210
102* GATA3_26560356_Chip-Seq_TH2_Human0.82584341
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82577000
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82009592
105GATA2_19941826_ChIP-Seq_K562_Human0.81898272
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81871504
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81731860
108LXR_22292898_ChIP-Seq_THP-1_Human0.81296236
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80835850
110SPI1_20517297_ChIP-Seq_HL60_Human0.80298589
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77191267
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76993160
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76117014
114GATA1_22025678_ChIP-Seq_K562_Human0.75098274
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74830857
116SCL_19346495_ChIP-Seq_HPC-7_Human0.74196107
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.73987439
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.73524399
119TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73240660
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73081501
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72673580
122TP53_16413492_ChIP-PET_HCT116_Human0.72359600
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72356983
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71753151
125TP63_23658742_ChIP-Seq_EP156T_Human0.71645220
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71636893
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.71241189
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.71138483
129KDM2B_26808549_Chip-Seq_DND41_Human0.70410709
130MYB_26560356_Chip-Seq_TH1_Human0.69808898
131SMRT_27268052_Chip-Seq_Bcells_Human0.69553975
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.69305305
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67483798
134PU1_27457419_Chip-Seq_LIVER_Mouse0.66570730
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66406242
136PIAS1_25552417_ChIP-Seq_VCAP_Human0.66300374
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64635260
138ZFP57_27257070_Chip-Seq_ESCs_Mouse0.64501210
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.63663556
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.63342320
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.63078585
142STAT3_18555785_Chip-Seq_ESCs_Mouse0.63076714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.26248056
2MP0006082_CNS_inflammation3.84303461
3MP0002148_abnormal_hypersensitivity_rea3.65810037
4MP0003436_decreased_susceptibility_to3.62861526
5MP0002419_abnormal_innate_immunity3.25354927
6MP0005058_abnormal_lysosome_morphology3.04723204
7MP0009785_altered_susceptibility_to2.96392246
8MP0005000_abnormal_immune_tolerance2.95721257
9MP0003303_peritoneal_inflammation2.94153808
10MP0005387_immune_system_phenotype2.89650456
11MP0001790_abnormal_immune_system2.89650456
12MP0000685_abnormal_immune_system2.74503863
13MP0005025_abnormal_response_to2.74295660
14MP0005671_abnormal_response_to2.67933811
15MP0002452_abnormal_antigen_presenting2.64506054
16MP0003724_increased_susceptibility_to2.57841477
17MP0004510_myositis2.57455353
18MP0001853_heart_inflammation2.50492583
19MP0003075_altered_response_to2.45510659
20MP0003690_abnormal_glial_cell2.25965325
21MP0001800_abnormal_humoral_immune2.17516142
22MP0002723_abnormal_immune_serum2.17064938
23MP0001819_abnormal_immune_cell2.15949557
24MP0003763_abnormal_thymus_physiology2.10959880
25MP0005464_abnormal_platelet_physiology2.04934715
26MP0002420_abnormal_adaptive_immunity2.03955822
27MP0003172_abnormal_lysosome_physiology1.98007213
28MP0003866_abnormal_defecation1.94202043
29MP0002090_abnormal_vision1.88191307
30MP0002405_respiratory_system_inflammati1.81668550
31MP0001533_abnormal_skeleton_physiology1.81449334
32MP0000343_altered_response_to1.79737348
33MP0001873_stomach_inflammation1.76624260
34MP0009764_decreased_sensitivity_to1.75159611
35MP0003183_abnormal_peptide_metabolism1.69713954
36MP0005166_decreased_susceptibility_to1.65374270
37MP0001845_abnormal_inflammatory_respons1.58196305
38MP0003806_abnormal_nucleotide_metabolis1.58146788
39MP0005310_abnormal_salivary_gland1.57319488
40MP0002139_abnormal_hepatobiliary_system1.54753831
41MP0003191_abnormal_cellular_cholesterol1.50595042
42MP0005360_urolithiasis1.50084814
43MP0002006_tumorigenesis1.50000481
44MP0002138_abnormal_hepatobiliary_system1.47219934
45MP0002998_abnormal_bone_remodeling1.46037738
46MP0004782_abnormal_surfactant_physiolog1.41990270
47MP0009840_abnormal_foam_cell1.40643642
48MP0005670_abnormal_white_adipose1.31336417
49MP0008469_abnormal_protein_level1.30527157
50MP0003828_pulmonary_edema1.29323114
51MP0005365_abnormal_bile_salt1.24921590
52MP0005167_abnormal_blood-brain_barrier1.24738148
53MP0003136_yellow_coat_color1.24136025
54MP0001663_abnormal_digestive_system1.22948727
55MP0003448_altered_tumor_morphology1.21194246
56MP0004947_skin_inflammation1.21071873
57MP0000716_abnormal_immune_system1.19657416
58MP0000604_amyloidosis1.17905227
59MP0005085_abnormal_gallbladder_physiolo1.17827119
60MP0010155_abnormal_intestine_physiology1.16176070
61MP0008260_abnormal_autophagy1.16103101
62MP0002009_preneoplasia1.15544399
63MP0000920_abnormal_myelination1.15404521
64MP0009333_abnormal_splenocyte_physiolog1.15310181
65MP0002254_reproductive_system_inflammat1.12472559
66MP0002396_abnormal_hematopoietic_system1.12074369
67MP0002132_abnormal_respiratory_system1.11912288
68MP0001958_emphysema1.10963243
69MP0009278_abnormal_bone_marrow1.08435995
70MP0002166_altered_tumor_susceptibility1.05478297
71MP0008875_abnormal_xenobiotic_pharmacok1.02471986
72MP0008438_abnormal_cutaneous_collagen1.01082435
73MP0000858_altered_metastatic_potential1.00883524
74MP0000490_abnormal_crypts_of0.98954697
75MP0000703_abnormal_thymus_morphology0.98844962
76MP0001851_eye_inflammation0.97337296
77MP0005397_hematopoietic_system_phenotyp0.96168168
78MP0001545_abnormal_hematopoietic_system0.96168168
79MP0005164_abnormal_response_to0.94350935
80MP0001986_abnormal_taste_sensitivity0.93551844
81MP0005390_skeleton_phenotype0.93195443
82MP0003252_abnormal_bile_duct0.93126732
83MP0009046_muscle_twitch0.90950464
84MP0002398_abnormal_bone_marrow0.89591871
85MP0003045_fibrosis0.89440852
86MP0002876_abnormal_thyroid_physiology0.88385531
87MP0005451_abnormal_body_composition0.85847914
88MP0002429_abnormal_blood_cell0.83257854
89MP0004858_abnormal_nervous_system0.83017769
90MP0009643_abnormal_urine_homeostasis0.82809070
91MP0004883_abnormal_blood_vessel0.80387947
92MP0001765_abnormal_ion_homeostasis0.80365220
93MP0003195_calcinosis0.78670070
94MP0001764_abnormal_homeostasis0.78155590
95MP0003279_aneurysm0.77393826
96MP0003186_abnormal_redox_activity0.77306301
97MP0001440_abnormal_grooming_behavior0.77092786
98MP0000689_abnormal_spleen_morphology0.77087474
99MP0005319_abnormal_enzyme/_coenzyme0.76187025
100MP0002295_abnormal_pulmonary_circulatio0.75591174
101MP0005075_abnormal_melanosome_morpholog0.75235393
102MP0005381_digestive/alimentary_phenotyp0.75036390
103MP0001984_abnormal_olfaction0.74964980
104MP0003300_gastrointestinal_ulcer0.74892414
105MP0010386_abnormal_urinary_bladder0.74150696
106MP0003646_muscle_fatigue0.72602845
107MP0003634_abnormal_glial_cell0.72553740
108MP0006054_spinal_hemorrhage0.72517666
109MP0008961_abnormal_basal_metabolism0.72462480
110MP0003656_abnormal_erythrocyte_physiolo0.71957661
111MP0010329_abnormal_lipoprotein_level0.71663020
112MP0000249_abnormal_blood_vessel0.71291689
113MP0001666_abnormal_nutrient_absorption0.70306961
114MP0005165_increased_susceptibility_to0.69697544
115MP0003633_abnormal_nervous_system0.68191347
116MP0000767_abnormal_smooth_muscle0.67633257
117MP0005174_abnormal_tail_pigmentation0.65140073
118MP0003329_amyloid_beta_deposits0.65020541
119MP0009763_increased_sensitivity_to0.64809844
120MP0003566_abnormal_cell_adhesion0.61650765
121MP0002933_joint_inflammation0.59061419
122MP0005076_abnormal_cell_differentiation0.58260854
123MP0003795_abnormal_bone_structure0.57526471
124MP0001881_abnormal_mammary_gland0.57156126
125MP0002722_abnormal_immune_system0.57020601
126MP0004130_abnormal_muscle_cell0.56784858
127MP0002277_abnormal_respiratory_mucosa0.55802379
128MP0002136_abnormal_kidney_physiology0.55779415
129MP0008004_abnormal_stomach_pH0.54955267
130MP0005388_respiratory_system_phenotype0.54878271
131MP0002133_abnormal_respiratory_system0.54878271
132MP0003950_abnormal_plasma_membrane0.53715726
133MP0000465_gastrointestinal_hemorrhage0.51537945
134MP0005595_abnormal_vascular_smooth0.51190597

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)8.06209136
2Increased cerebral lipofuscin (HP:0011813)7.84867985
3Recurrent abscess formation (HP:0002722)7.25581477
4Recurrent bacterial skin infections (HP:0005406)6.50089949
5Eczematoid dermatitis (HP:0000976)6.45385659
6Recurrent gram-negative bacterial infections (HP:0005420)5.81348339
7Abnormality of liposaccharide metabolism (HP:0010968)5.30845375
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.30845375
9Abnormality of glycolipid metabolism (HP:0010969)5.30845375
10Loss of speech (HP:0002371)5.30303616
11Obstructive lung disease (HP:0006536)5.00311458
12Chronic obstructive pulmonary disease (HP:0006510)5.00311458
13Abnormality of macrophages (HP:0004311)4.72646039
14Vacuolated lymphocytes (HP:0001922)4.45589028
15Mediastinal lymphadenopathy (HP:0100721)4.34711871
16Gingivitis (HP:0000230)3.84352705
17Recurrent skin infections (HP:0001581)3.78037480
18Systemic lupus erythematosus (HP:0002725)3.68116524
19Abolished electroretinogram (ERG) (HP:0000550)3.57690906
20Gastrointestinal infarctions (HP:0005244)3.46719510
21Encephalitis (HP:0002383)3.39714198
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.38907478
23Chronic otitis media (HP:0000389)3.32545228
24Progressive visual loss (HP:0000529)3.18341015
25Abnormality of complement system (HP:0005339)3.14089735
26Recurrent fungal infections (HP:0002841)3.13730774
27Vasculitis (HP:0002633)3.11433920
28T lymphocytopenia (HP:0005403)3.10175682
29Nephritis (HP:0000123)3.09911534
30Abnormality of T cell number (HP:0011839)3.06935306
31Keratoconjunctivitis sicca (HP:0001097)3.04841103
32Hemoptysis (HP:0002105)3.00165633
33Myositis (HP:0100614)2.97109991
34Keratoconjunctivitis (HP:0001096)2.95827977
35Cerebral palsy (HP:0100021)2.92235926
36Orchitis (HP:0100796)2.87523156
37Stomatitis (HP:0010280)2.83747353
38Dysostosis multiplex (HP:0000943)2.83174700
39Cellulitis (HP:0100658)2.83058429
40Meningitis (HP:0001287)2.79326814
41Optic neuritis (HP:0100653)2.78197084
42Retrobulbar optic neuritis (HP:0100654)2.78197084
43Abnormality of T cells (HP:0002843)2.75475996
44Interstitial pulmonary disease (HP:0006530)2.74993822
45Poor head control (HP:0002421)2.73806861
46Elevated erythrocyte sedimentation rate (HP:0003565)2.73767307
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72636893
48Thick nail (HP:0001805)2.70956519
49Chest pain (HP:0100749)2.70248819
50Panhypogammaglobulinemia (HP:0003139)2.68165134
51Spontaneous hematomas (HP:0007420)2.60145566
52Chronic diarrhea (HP:0002028)2.57622205
53Leukocytosis (HP:0001974)2.57147661
54Abnormality of the pleura (HP:0002103)2.57052534
55Glomerulonephritis (HP:0000099)2.56478672
56Anorexia (HP:0002039)2.56067713
57Pulmonary infiltrates (HP:0002113)2.54594275
58Periodontitis (HP:0000704)2.53343675
59Epistaxis (HP:0000421)2.51345992
60Pustule (HP:0200039)2.50063463
61Petechiae (HP:0000967)2.49673282
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48634565
63Axonal loss (HP:0003447)2.48572931
64Pulmonary embolism (HP:0002204)2.47221160
65Gangrene (HP:0100758)2.46061949
66Urticaria (HP:0001025)2.45423793
67Autoimmune thrombocytopenia (HP:0001973)2.44356874
68Recurrent pneumonia (HP:0006532)2.42804677
69Basal ganglia calcification (HP:0002135)2.42380152
70Inflammation of the large intestine (HP:0002037)2.41155652
71Gingival bleeding (HP:0000225)2.40911006
72Recurrent bronchitis (HP:0002837)2.39732121
73Diminished motivation (HP:0000745)2.39323082
74Acrocyanosis (HP:0001063)2.38994980
75Prolonged bleeding time (HP:0003010)2.38364179
76Agammaglobulinemia (HP:0004432)2.36721097
77Increased IgE level (HP:0003212)2.36463859
78Emphysema (HP:0002097)2.36249575
79Abnormality of T cell physiology (HP:0011840)2.35561802
80Malnutrition (HP:0004395)2.34541656
81Abnormality of the prostate (HP:0008775)2.32632825
82Chronic mucocutaneous candidiasis (HP:0002728)2.32231005
83Recurrent cutaneous fungal infections (HP:0011370)2.32231005
84Apathy (HP:0000741)2.31340142
85Granulocytopenia (HP:0001913)2.29796625
86Macular degeneration (HP:0000608)2.28457907
87Urinary glycosaminoglycan excretion (HP:0003541)2.24874484
88Mucopolysacchariduria (HP:0008155)2.24874484
89Episodic fever (HP:0001954)2.22691927
90Recurrent viral infections (HP:0004429)2.22529123
91Cheilitis (HP:0100825)2.22336327
92Gastrointestinal inflammation (HP:0004386)2.21521936
93Abnormality of the pericardium (HP:0001697)2.21357647
94Autoimmune hemolytic anemia (HP:0001890)2.20933776
95Myocardial infarction (HP:0001658)2.19621791
96Eosinophilia (HP:0001880)2.18764078
97Joint swelling (HP:0001386)2.18566137
98Nasal polyposis (HP:0100582)2.18167424
99Polyneuropathy (HP:0001271)2.17170728
100Amyloidosis (HP:0011034)2.16360538
101Abnormality of polysaccharide metabolism (HP:0011012)2.15598706
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15598706
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15598706
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14218957
105Prostate neoplasm (HP:0100787)2.12990012
106Restrictive lung disease (HP:0002091)2.12408718
107Xerostomia (HP:0000217)2.12329200
108Disinhibition (HP:0000734)2.11952606
109Increased IgM level (HP:0003496)2.11288815
110Testicular atrophy (HP:0000029)2.11244780
111Hematochezia (HP:0002573)2.11207463
112Pancreatitis (HP:0001733)2.08644477
113Purpura (HP:0000979)2.07932111
114Osteomyelitis (HP:0002754)2.07559841
115Abnormality of iron homeostasis (HP:0011031)2.06522383
116Neurofibrillary tangles (HP:0002185)2.06174424
117Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03695241
118J-shaped sella turcica (HP:0002680)2.03203518
119Recurrent lower respiratory tract infections (HP:0002783)2.02161216
120Abnormality of the nasal mucosa (HP:0000433)1.98328980
121IgG deficiency (HP:0004315)1.97045699
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.96262242
123Osteolytic defects of the hand bones (HP:0009699)1.96262242
124Hypochromic anemia (HP:0001931)1.96256397
125Vertigo (HP:0002321)1.96053334
126Abnormality of B cell number (HP:0010975)1.95896333
127Glomerulopathy (HP:0100820)1.94609526
128Hepatosplenomegaly (HP:0001433)1.93334736
129Colitis (HP:0002583)1.93133738
130Abnormality of eosinophils (HP:0001879)1.92903172
131Abnormality of transition element cation homeostasis (HP:0011030)1.92893058
132Acne (HP:0001061)1.88358474
133Arterial thrombosis (HP:0004420)1.82757058
134Chronic sinusitis (HP:0011109)1.81075151
135Abnormality of binocular vision (HP:0011514)1.79691529
136Diplopia (HP:0000651)1.79691529
137Segmental peripheral demyelination/remyelination (HP:0003481)1.77696255
138Skin rash (HP:0000988)1.77597942
139Joint hemorrhage (HP:0005261)1.77597258
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77567329
141Tetraparesis (HP:0002273)1.75329345
142Hypergammaglobulinemia (HP:0010702)1.73022014
143Skin ulcer (HP:0200042)1.69128487
144Premature loss of primary teeth (HP:0006323)1.65330928
145Increased serum ferritin (HP:0003281)1.64899128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.38150958
2BLK4.21804995
3MAP3K143.98208453
4MAP4K13.83733631
5IRAK43.24929580
6TBK13.13299224
7IRAK32.63993522
8BCKDK2.57934211
9TYK22.39849488
10MST42.38292964
11PBK2.31285236
12GRK62.14336743
13MAP3K122.14148401
14IKBKB2.11005078
15EPHB11.98363127
16CSK1.92467248
17CSF1R1.91396869
18TNK21.83932751
19KIT1.81223294
20TXK1.80144595
21JAK11.76260018
22IKBKE1.71708921
23MAP3K31.65631407
24SYK1.55105904
25MAP3K111.54113913
26GRK11.51909131
27MAP2K31.51516353
28JAK31.43616729
29TAOK11.35797487
30LYN1.35587552
31TESK21.35496973
32PIM21.31926619
33TEC1.31873055
34ACVR1B1.30977567
35GRK71.28370551
36FGR1.28174761
37HCK1.28024956
38BMPR21.22937527
39BTK1.22466013
40NUAK11.16350033
41ERN11.15214308
42TGFBR21.12188374
43FES1.03949640
44NEK91.03880069
45BMX1.03297127
46CLK11.02750925
47YES11.00827223
48ADRBK20.95672106
49ITK0.90771497
50JAK20.90352132
51MATK0.88251385
52TAOK30.87944156
53ZAP700.86963475
54MAP3K10.86201486
55ABL20.82889920
56LCK0.80127342
57TRIB30.77602789
58TRPM70.77298927
59TAOK20.77012977
60FGFR30.76951219
61STK100.76861364
62LRRK20.76155654
63PRKCD0.75360107
64MAP2K60.73219860
65CAMK1D0.72119810
66ABL10.72027451
67MAP3K130.71831177
68STK240.71552306
69PRKCQ0.71394075
70MAPK150.71257914
71MST1R0.70880253
72CAMKK20.68804013
73PDK10.67444637
74IRAK10.66350464
75DAPK20.64794888
76TLK10.64330951
77NLK0.62802285
78PRKD20.61028156
79MYLK0.59346105
80PDPK10.57812015
81CAMKK10.57371843
82MUSK0.56098994
83FRK0.56052212
84MARK30.55766402
85PIM10.54835883
86KDR0.53991494
87RPS6KC10.53456593
88RPS6KL10.53456593
89MAP2K20.51176594
90PKN10.48013476
91DMPK0.47606635
92MAPK70.47234765
93MAPKAPK30.47086819
94FYN0.46701283
95CDC42BPA0.46326071
96PIK3CG0.46296505
97DAPK30.45597584
98EIF2AK20.43513601
99ERBB30.43461218
100IGF1R0.42966856
101BMPR1B0.42293574
102EPHA30.41962802
103HIPK20.41010448
104PIK3CA0.40835448
105CHUK0.39260524
106MAP3K20.38887917
107WNK40.38876278
108CDK190.38874937
109PRKCE0.38826526
110MAP3K50.37435969
111IRAK20.37218652
112MAPK120.36950585
113PAK40.34862412
114PTK60.34450275
115RIPK10.33779257
116NTRK20.33431324
117CASK0.32395397
118EIF2AK30.31895956
119RPS6KA60.31688710
120EGFR0.31338340
121PRPF4B0.31218109
122MAPKAPK20.31082055
123MOS0.30880432
124SIK30.30640860
125MAPK110.29492336
126RPS6KA40.28731697
127GRK50.28066412
128PRKG20.27729464
129INSR0.27468479

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.03851724
2Lysosome_Homo sapiens_hsa041422.98261787
3Staphylococcus aureus infection_Homo sapiens_hsa051502.84020811
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.68462758
5Malaria_Homo sapiens_hsa051442.40107918
6Tuberculosis_Homo sapiens_hsa051522.32322190
7Graft-versus-host disease_Homo sapiens_hsa053322.27899713
8Rheumatoid arthritis_Homo sapiens_hsa053232.27248192
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26489577
10Pertussis_Homo sapiens_hsa051332.25562020
11Osteoclast differentiation_Homo sapiens_hsa043802.25552317
12Phagosome_Homo sapiens_hsa041452.13946928
13Legionellosis_Homo sapiens_hsa051342.02500675
14Salmonella infection_Homo sapiens_hsa051321.97331809
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.84298918
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.75912697
17Other glycan degradation_Homo sapiens_hsa005111.73620826
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72449677
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68831722
20Fatty acid elongation_Homo sapiens_hsa000621.66821579
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65987183
22Chemokine signaling pathway_Homo sapiens_hsa040621.63498307
23African trypanosomiasis_Homo sapiens_hsa051431.54518949
24Allograft rejection_Homo sapiens_hsa053301.53938124
25Asthma_Homo sapiens_hsa053101.53819349
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.48481295
27B cell receptor signaling pathway_Homo sapiens_hsa046621.45294368
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44688712
29Influenza A_Homo sapiens_hsa051641.41880600
30Hematopoietic cell lineage_Homo sapiens_hsa046401.38808181
31TNF signaling pathway_Homo sapiens_hsa046681.37266459
32Measles_Homo sapiens_hsa051621.36004743
33Toxoplasmosis_Homo sapiens_hsa051451.33783916
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27187161
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25956793
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25569299
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20517315
38Type I diabetes mellitus_Homo sapiens_hsa049401.15853251
39Shigellosis_Homo sapiens_hsa051311.14241082
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12204665
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.11790346
42Caffeine metabolism_Homo sapiens_hsa002321.07451027
43Mineral absorption_Homo sapiens_hsa049781.07180580
44Apoptosis_Homo sapiens_hsa042101.00650027
45Antigen processing and presentation_Homo sapiens_hsa046120.99226476
46Collecting duct acid secretion_Homo sapiens_hsa049660.98991506
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.97208151
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.95157939
49Viral myocarditis_Homo sapiens_hsa054160.93260401
50Herpes simplex infection_Homo sapiens_hsa051680.91380323
51Complement and coagulation cascades_Homo sapiens_hsa046100.91195158
52Hepatitis C_Homo sapiens_hsa051600.91018393
53Autoimmune thyroid disease_Homo sapiens_hsa053200.91004708
54Amoebiasis_Homo sapiens_hsa051460.87676896
55Linoleic acid metabolism_Homo sapiens_hsa005910.87324346
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86844146
57Sphingolipid metabolism_Homo sapiens_hsa006000.86350562
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84810942
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83111596
60Ether lipid metabolism_Homo sapiens_hsa005650.82380756
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82072577
62Fatty acid metabolism_Homo sapiens_hsa012120.81880298
63Fatty acid biosynthesis_Homo sapiens_hsa000610.81135186
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80706034
65Platelet activation_Homo sapiens_hsa046110.78057840
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74041417
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73821035
68Hepatitis B_Homo sapiens_hsa051610.70104929
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.69817081
70PPAR signaling pathway_Homo sapiens_hsa033200.68173773
71Steroid biosynthesis_Homo sapiens_hsa001000.67831887
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.67593952
73Olfactory transduction_Homo sapiens_hsa047400.64124197
74Chemical carcinogenesis_Homo sapiens_hsa052040.61873347
75Vitamin digestion and absorption_Homo sapiens_hsa049770.61402549
76Primary immunodeficiency_Homo sapiens_hsa053400.59733104
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56512312
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56350281
79Vibrio cholerae infection_Homo sapiens_hsa051100.55734267
80Prion diseases_Homo sapiens_hsa050200.55546626
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.52371063
82ABC transporters_Homo sapiens_hsa020100.51862503
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51692597
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49907409
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48126989
86T cell receptor signaling pathway_Homo sapiens_hsa046600.48071852
87Sulfur metabolism_Homo sapiens_hsa009200.47883883
88Fat digestion and absorption_Homo sapiens_hsa049750.46103794
89Renin-angiotensin system_Homo sapiens_hsa046140.45875262
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44366111
91Starch and sucrose metabolism_Homo sapiens_hsa005000.44308563
92Histidine metabolism_Homo sapiens_hsa003400.42875943
93Nitrogen metabolism_Homo sapiens_hsa009100.42834891
94Arachidonic acid metabolism_Homo sapiens_hsa005900.42735862
95Tryptophan metabolism_Homo sapiens_hsa003800.40086550
96Retinol metabolism_Homo sapiens_hsa008300.40055670
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38161080
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37827358
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37261633
100Endocytosis_Homo sapiens_hsa041440.36286929
101Epstein-Barr virus infection_Homo sapiens_hsa051690.35473526
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.34141548
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.32575851
104Salivary secretion_Homo sapiens_hsa049700.31005467
105Systemic lupus erythematosus_Homo sapiens_hsa053220.29771890
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29727132
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.28975040
108Acute myeloid leukemia_Homo sapiens_hsa052210.28792834
109Pancreatic cancer_Homo sapiens_hsa052120.28691390
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.28405531
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28030490
112Gastric acid secretion_Homo sapiens_hsa049710.27964028
113Insulin resistance_Homo sapiens_hsa049310.27853490
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27809773
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27749397
116Dorso-ventral axis formation_Homo sapiens_hsa043200.26718206
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.26268982
118Morphine addiction_Homo sapiens_hsa050320.25786536
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24546057
120Peroxisome_Homo sapiens_hsa041460.23818520
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23216527
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23071098
123Glycerolipid metabolism_Homo sapiens_hsa005610.22120828
124Regulation of autophagy_Homo sapiens_hsa041400.21520916
125Prolactin signaling pathway_Homo sapiens_hsa049170.21133713
126cAMP signaling pathway_Homo sapiens_hsa040240.20399879

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »