NAALAD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin transmembrane transport (GO:0035461)6.74943052
2purine nucleobase biosynthetic process (GO:0009113)6.33703738
3ribosome assembly (GO:0042255)6.28880222
4mitotic metaphase plate congression (GO:0007080)5.81790383
5regulation of spindle organization (GO:0090224)5.81191160
6nucleobase biosynthetic process (GO:0046112)5.23653442
7folic acid transport (GO:0015884)5.21356482
8folic acid metabolic process (GO:0046655)5.02899835
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.01540919
10regulation of mitotic spindle organization (GO:0060236)4.96348394
11pantothenate metabolic process (GO:0015939)4.76855466
12lung-associated mesenchyme development (GO:0060484)4.68700352
13ribosome biogenesis (GO:0042254)4.47721504
14DNA replication checkpoint (GO:0000076)4.47588074
15metaphase plate congression (GO:0051310)4.47109684
16positive regulation of chromosome segregation (GO:0051984)4.21563586
17blastocyst development (GO:0001824)4.21114729
18termination of RNA polymerase I transcription (GO:0006363)4.18447871
19rRNA modification (GO:0000154)4.17763633
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.15390945
21regulation of non-canonical Wnt signaling pathway (GO:2000050)4.09283813
22transcription elongation from RNA polymerase I promoter (GO:0006362)4.01999389
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.99383629
24regulation of G0 to G1 transition (GO:0070316)3.97513474
25GMP metabolic process (GO:0046037)3.91675474
26transcription from RNA polymerase I promoter (GO:0006360)3.83614017
27spindle checkpoint (GO:0031577)3.82724560
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.73356191
29termination of RNA polymerase III transcription (GO:0006386)3.73356191
30transcription initiation from RNA polymerase I promoter (GO:0006361)3.71078176
31presynaptic membrane assembly (GO:0097105)3.70178938
32mitotic spindle checkpoint (GO:0071174)3.69702045
33autophagic vacuole assembly (GO:0000045)3.69096721
34maturation of 5.8S rRNA (GO:0000460)3.58389429
35ventricular cardiac muscle cell development (GO:0055015)3.57662006
36histone-serine phosphorylation (GO:0035404)3.56639068
37replication fork processing (GO:0031297)3.56185470
38proteasome assembly (GO:0043248)3.55001542
39regulation of chromosome segregation (GO:0051983)3.54784125
40modified amino acid transport (GO:0072337)3.54346604
41meiosis I (GO:0007127)3.53663583
42CDP-diacylglycerol metabolic process (GO:0046341)3.52050377
437-methylguanosine mRNA capping (GO:0006370)3.50281552
44resolution of meiotic recombination intermediates (GO:0000712)3.48715350
45mitotic spindle assembly checkpoint (GO:0007094)3.47741736
46negative regulation of fibroblast apoptotic process (GO:2000270)3.47612845
47negative regulation of chromosome segregation (GO:0051985)3.47604091
48biotin metabolic process (GO:0006768)3.46451277
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.44914076
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44914076
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44914076
52negative regulation of sister chromatid segregation (GO:0033046)3.44914076
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43057676
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37939001
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.37908668
56spindle assembly checkpoint (GO:0071173)3.37264840
57dorsal/ventral axis specification (GO:0009950)3.36379526
587-methylguanosine RNA capping (GO:0009452)3.35674133
59RNA capping (GO:0036260)3.35674133
60embryonic foregut morphogenesis (GO:0048617)3.34996461
61intestinal epithelial cell development (GO:0060576)3.34350538
62rRNA methylation (GO:0031167)3.34206031
63S-adenosylmethionine metabolic process (GO:0046500)3.33912168
64regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32678052
65somite development (GO:0061053)3.31925747
66synaptonemal complex assembly (GO:0007130)3.29747820
67intraciliary transport (GO:0042073)3.29693295
68regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.27813484
69regulation of translation in response to stress (GO:0043555)3.26455986
70monoubiquitinated protein deubiquitination (GO:0035520)3.25268402
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25061120
72oocyte maturation (GO:0001556)3.24284493
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23927119
74establishment of chromosome localization (GO:0051303)3.23635011
75nucleotide-sugar biosynthetic process (GO:0009226)3.23065745
76protein localization to kinetochore (GO:0034501)3.22083360
77artery development (GO:0060840)3.21647164
78presynaptic membrane organization (GO:0097090)3.20873969
79NADH metabolic process (GO:0006734)3.19786672
80vitamin transport (GO:0051180)3.16322479
81UDP-N-acetylglucosamine metabolic process (GO:0006047)3.15309103
82regulation of exit from mitosis (GO:0007096)3.15214950
83labyrinthine layer development (GO:0060711)3.14687270
84mitotic nuclear envelope disassembly (GO:0007077)3.14653245
85L-methionine salvage (GO:0071267)3.14176742
86L-methionine biosynthetic process (GO:0071265)3.14176742
87amino acid salvage (GO:0043102)3.14176742
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13892928
89male meiosis I (GO:0007141)3.12471685
90cofactor transport (GO:0051181)3.11537216
91attachment of spindle microtubules to kinetochore (GO:0008608)3.11448910
92thalamus development (GO:0021794)3.10437972
93primitive streak formation (GO:0090009)3.09538355
94limb bud formation (GO:0060174)3.09280389
95behavioral response to ethanol (GO:0048149)3.07715647
96behavioral response to nicotine (GO:0035095)3.07558654
97regulation of sister chromatid segregation (GO:0033045)3.07137330
98regulation of mitotic sister chromatid separation (GO:0010965)3.07137330
99regulation of mitotic sister chromatid segregation (GO:0033047)3.07137330
100glycine metabolic process (GO:0006544)3.06224597
101genitalia morphogenesis (GO:0035112)3.05624093
102pericardium development (GO:0060039)3.05385957
103somite rostral/caudal axis specification (GO:0032525)3.03458822
104skeletal muscle tissue regeneration (GO:0043403)2.99091109
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98518160
106serine family amino acid catabolic process (GO:0009071)2.95341537
107nuclear envelope organization (GO:0006998)2.95120791
108embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95003142
109membrane disassembly (GO:0030397)2.94856582
110nuclear envelope disassembly (GO:0051081)2.94856582
111mitotic sister chromatid segregation (GO:0000070)2.93678155
112kinetochore organization (GO:0051383)2.93581346
113synaptonemal complex organization (GO:0070193)2.93310997
114peptidyl-threonine dephosphorylation (GO:0035970)2.92744615
115ribonucleoprotein complex biogenesis (GO:0022613)2.92509957
116polyamine biosynthetic process (GO:0006596)2.92480420
117positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.92409107
118formation of translation preinitiation complex (GO:0001731)2.92066181
119regulation of mesoderm development (GO:2000380)2.91853945
120chromatin remodeling at centromere (GO:0031055)2.91402916
121DNA-templated transcription, elongation (GO:0006354)2.91325597
122protein K6-linked ubiquitination (GO:0085020)2.90709660
123rRNA processing (GO:0006364)2.89519705
124kinetochore assembly (GO:0051382)2.89449161
125epithelial cilium movement (GO:0003351)2.89163926
126protein localization to chromosome, centromeric region (GO:0071459)2.88458582
127response to pheromone (GO:0019236)2.88386785
128negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.87488888
129piRNA metabolic process (GO:0034587)2.84028464
130gastrulation with mouth forming second (GO:0001702)2.83583371
131neuron fate determination (GO:0048664)2.83208203
132protein localization to synapse (GO:0035418)2.81692138
133CENP-A containing nucleosome assembly (GO:0034080)2.80025299
134cartilage morphogenesis (GO:0060536)2.79282928
135organ growth (GO:0035265)2.74865758
136pyrimidine nucleobase catabolic process (GO:0006208)2.74536503
137negative regulation of astrocyte differentiation (GO:0048712)2.70428676
138retinal ganglion cell axon guidance (GO:0031290)2.68355849
139pancreas development (GO:0031016)2.64186684
140positive regulation of gastrulation (GO:2000543)2.63183036
141nonmotile primary cilium assembly (GO:0035058)2.62694762
142regulation of neuron migration (GO:2001222)2.60244320
143apical protein localization (GO:0045176)2.57678135
144negative chemotaxis (GO:0050919)2.57174423
145protein localization to cilium (GO:0061512)2.53505672
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53427662
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51794169
148positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51342438
149histone exchange (GO:0043486)2.50576164
150cilium morphogenesis (GO:0060271)2.49009662
151otic vesicle formation (GO:0030916)2.47423357
152synapsis (GO:0007129)2.46977441
153cellular response to cholesterol (GO:0071397)2.42592284
154endoderm formation (GO:0001706)2.40664052
155embryonic pattern specification (GO:0009880)2.40541770
156seminiferous tubule development (GO:0072520)2.40448479
157positive regulation of male gonad development (GO:2000020)2.37935913
158cilium organization (GO:0044782)2.37393467
159cilium assembly (GO:0042384)2.35451554
160protein polyglutamylation (GO:0018095)2.34924769
161neuronal stem cell maintenance (GO:0097150)2.34476626
162female gonad development (GO:0008585)2.33752237
163cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32559613
164postsynaptic membrane organization (GO:0001941)2.32225496
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32224558
166negative regulation of striated muscle cell apoptotic process (GO:0010664)2.29268465
167DNA replication-independent nucleosome organization (GO:0034724)2.28684865
168DNA replication-independent nucleosome assembly (GO:0006336)2.28684865
169regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.28503929
170embryonic axis specification (GO:0000578)2.27288565
171regulation of development, heterochronic (GO:0040034)2.26384742
172retinal cone cell development (GO:0046549)2.26035434
173olfactory bulb development (GO:0021772)2.25638264
174negative regulation of DNA recombination (GO:0045910)2.25570634
175appendage development (GO:0048736)2.24411374
176limb development (GO:0060173)2.24411374
177DNA double-strand break processing (GO:0000729)2.23959065
178regulation of timing of cell differentiation (GO:0048505)2.22341154
179axonal fasciculation (GO:0007413)2.21230613
180regulation of male gonad development (GO:2000018)2.20739605
181C4-dicarboxylate transport (GO:0015740)2.20671058
182negative regulation of transcription regulatory region DNA binding (GO:2000678)2.20324185
183epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.20005280
184neural tube formation (GO:0001841)2.19626749
185centriole replication (GO:0007099)2.19466684
186regulation of collateral sprouting (GO:0048670)2.18672338
187smoothened signaling pathway (GO:0007224)2.17576439
188neuronal action potential propagation (GO:0019227)2.17515443
189cellular response to sterol (GO:0036315)2.16554859
190head development (GO:0060322)2.15909919
191gamma-aminobutyric acid transport (GO:0015812)2.15202148
192regulation of sulfur metabolic process (GO:0042762)2.14995709
193cilium movement (GO:0003341)2.14893925
194regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.14385355
195detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.13984698
196reciprocal DNA recombination (GO:0035825)2.12622568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.60719385
2E2F7_22180533_ChIP-Seq_HELA_Human4.58521744
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.57561863
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.45349529
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.97926603
6EZH2_22144423_ChIP-Seq_EOC_Human3.59971484
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.59410675
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47533098
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46038829
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.38669248
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.38160037
12TAF15_26573619_Chip-Seq_HEK293_Human3.09727061
13* AR_21909140_ChIP-Seq_LNCAP_Human3.05391564
14FUS_26573619_Chip-Seq_HEK293_Human2.88066355
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.86191911
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85893908
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.78968971
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67649106
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67078517
20GBX2_23144817_ChIP-Seq_PC3_Human2.64196859
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59714170
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58104788
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56483677
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.53149497
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.42662884
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41710675
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36602640
28EWS_26573619_Chip-Seq_HEK293_Human2.35971207
29ZNF274_21170338_ChIP-Seq_K562_Hela2.34926315
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34613969
31VDR_22108803_ChIP-Seq_LS180_Human2.30100174
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27677197
33ZNF263_19887448_ChIP-Seq_K562_Human2.26578188
34IGF1R_20145208_ChIP-Seq_DFB_Human2.25311298
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24561181
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20932229
37NANOG_18555785_ChIP-Seq_MESCs_Mouse2.19913499
38P300_19829295_ChIP-Seq_ESCs_Human2.18043587
39VDR_23849224_ChIP-Seq_CD4+_Human2.14090783
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10668898
41CBX2_27304074_Chip-Seq_ESCs_Mouse2.01782853
42RNF2_27304074_Chip-Seq_NSC_Mouse1.95884603
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93153930
44KAP1_22055183_ChIP-Seq_ESCs_Mouse1.85896258
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85118596
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81148760
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79734750
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77891589
49GABP_19822575_ChIP-Seq_HepG2_Human1.77230502
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.77198871
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.76894366
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75750746
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75586577
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.72252851
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70461051
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69939767
57IRF1_19129219_ChIP-ChIP_H3396_Human1.68994902
58XRN2_22483619_ChIP-Seq_HELA_Human1.68070302
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67275151
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64926310
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60711435
62SMAD4_21799915_ChIP-Seq_A2780_Human1.60185458
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59970204
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58232076
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57776415
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57776415
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57655444
68BCAT_22108803_ChIP-Seq_LS180_Human1.57082881
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56888161
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55749998
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55543456
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53623866
73DCP1A_22483619_ChIP-Seq_HELA_Human1.51549768
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.48545866
75FOXP3_21729870_ChIP-Seq_TREG_Human1.48431158
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.47625647
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47535676
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46632706
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45549690
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44608836
81STAT3_23295773_ChIP-Seq_U87_Human1.42877582
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42002938
83AR_25329375_ChIP-Seq_VCAP_Human1.41769801
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.40972664
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39987844
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.39126402
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.38337807
88AR_21572438_ChIP-Seq_LNCaP_Human1.37663678
89KDM5A_27292631_Chip-Seq_BREAST_Human1.37519660
90TCF4_22108803_ChIP-Seq_LS180_Human1.35165551
91CLOCK_20551151_ChIP-Seq_293T_Human1.34878169
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.34801322
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34459980
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.34337450
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34048221
96ER_23166858_ChIP-Seq_MCF-7_Human1.33542141
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33168908
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28555160
99CBP_20019798_ChIP-Seq_JUKART_Human1.28413068
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28413068
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27839344
102RUNX2_22187159_ChIP-Seq_PCA_Human1.27475586
103* TTF2_22483619_ChIP-Seq_HELA_Human1.27465928
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27320499
105TCF4_23295773_ChIP-Seq_U87_Human1.26764328
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25930413
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22415904
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21776488
109MYC_18940864_ChIP-ChIP_HL60_Human1.21185190
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20313301
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19783049
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19218529
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18739308
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18694978
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17528900
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17104378
117CIITA_25753668_ChIP-Seq_RAJI_Human1.16992150
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16559791
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16477375
120* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16054138
121NANOG_21062744_ChIP-ChIP_HESCs_Human1.15939162
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15380186
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15185672
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14009087
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12687221
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.12505012
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.10665251
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09982369
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09845763
130SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09744465
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09484192
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.08015357
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07393346
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07213378
135ELK1_19687146_ChIP-ChIP_HELA_Human1.07019007
136JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06951739
137SRF_21415370_ChIP-Seq_HL-1_Mouse1.06365409
138* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06002194
139SOX9_26525672_Chip-Seq_HEART_Mouse1.05506633
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03707736
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02888165
142HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02761418
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02559795
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02520510
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02071968
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.01123591
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00730963
148SOX2_21211035_ChIP-Seq_LN229_Gbm1.00620169
149NANOG_19829295_ChIP-Seq_ESCs_Human0.99355750
150SOX2_19829295_ChIP-Seq_ESCs_Human0.99355750
151TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99213261
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99124342
153* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98433522
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.98394961
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98171894
156REST_21632747_ChIP-Seq_MESCs_Mouse0.98133798
157NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98020534
158TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97966395
159JUN_21703547_ChIP-Seq_K562_Human0.97325162
160ISL1_27105846_Chip-Seq_CPCs_Mouse0.97318967
161PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95204143
162PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94459124
163ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92871336
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91915316
165NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91564471
166ESR2_21235772_ChIP-Seq_MCF-7_Human0.89742210
167NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89666340
168POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89549950
169NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89061388
170KAP1_27257070_Chip-Seq_ESCs_Mouse0.89003566
171CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88995324
172STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88646739
173MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88511170
174ESR1_21235772_ChIP-Seq_MCF-7_Human0.86638870
175FLI1_27457419_Chip-Seq_LIVER_Mouse0.86530802
176TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85870717
177NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84320255
178THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83464082
179RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83159720
180TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80729941
181GATA1_26923725_Chip-Seq_HPCs_Mouse0.80199114
182MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78697470
183SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78287394
184TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77751095
185SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77156999
186CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76812827
187POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76705098
188SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76188870
189SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74918164
190ATF3_27146783_Chip-Seq_COLON_Human0.74445440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.82783407
2MP0008438_abnormal_cutaneous_collagen4.66239196
3MP0003890_abnormal_embryonic-extraembry3.79253543
4MP0003718_maternal_effect3.76148860
5MP0005503_abnormal_tendon_morphology3.73289767
6MP0003111_abnormal_nucleus_morphology3.70846536
7MP0008260_abnormal_autophagy3.59880465
8MP0005275_abnormal_skin_tensile3.42906968
9MP0003880_abnormal_central_pattern3.42083920
10MP0006292_abnormal_olfactory_placode3.06920983
11MP0003122_maternal_imprinting3.04491342
12MP0001661_extended_life_span3.03040650
13MP0004957_abnormal_blastocyst_morpholog2.62375509
14MP0003121_genomic_imprinting2.41463423
15MP0003077_abnormal_cell_cycle2.36822693
16MP0010094_abnormal_chromosome_stability2.34630740
17MP0005377_hearing/vestibular/ear_phenot2.33507729
18MP0003878_abnormal_ear_physiology2.33507729
19MP0001542_abnormal_bone_strength2.29464173
20MP0009840_abnormal_foam_cell2.27983742
21MP0003787_abnormal_imprinting2.23426957
22MP0003786_premature_aging2.15317027
23MP0001529_abnormal_vocalization2.09404643
24MP0000537_abnormal_urethra_morphology2.09077443
25MP0000778_abnormal_nervous_system2.05948454
26MP0010030_abnormal_orbit_morphology2.05455333
27MP0002009_preneoplasia2.00177242
28MP0001293_anophthalmia1.93902274
29MP0005451_abnormal_body_composition1.93618323
30MP0006276_abnormal_autonomic_nervous1.79933711
31MP0002102_abnormal_ear_morphology1.79077912
32MP0000750_abnormal_muscle_regeneration1.78839025
33MP0000049_abnormal_middle_ear1.78215803
34MP0003123_paternal_imprinting1.76879216
35MP0001958_emphysema1.75042686
36MP0002282_abnormal_trachea_morphology1.75018642
37MP0008058_abnormal_DNA_repair1.71597304
38MP0002234_abnormal_pharynx_morphology1.71212436
39MP0006054_spinal_hemorrhage1.70492375
40MP0008932_abnormal_embryonic_tissue1.70221123
41MP0004084_abnormal_cardiac_muscle1.69318773
42MP0004133_heterotaxia1.69111829
43MP0005394_taste/olfaction_phenotype1.67337915
44MP0005499_abnormal_olfactory_system1.67337915
45MP0001730_embryonic_growth_arrest1.65533273
46MP0003119_abnormal_digestive_system1.65428229
47MP0002249_abnormal_larynx_morphology1.65010901
48MP0005395_other_phenotype1.64619139
49MP0008057_abnormal_DNA_replication1.59527725
50MP0005508_abnormal_skeleton_morphology1.57808259
51MP0003567_abnormal_fetal_cardiomyocyte1.55968785
52MP0001672_abnormal_embryogenesis/_devel1.54153268
53MP0005380_embryogenesis_phenotype1.54153268
54MP0001984_abnormal_olfaction1.52373631
55MP0002697_abnormal_eye_size1.48834842
56MP0005257_abnormal_intraocular_pressure1.48425908
57MP0005551_abnormal_eye_electrophysiolog1.45468099
58MP0005187_abnormal_penis_morphology1.44803668
59MP0009384_cardiac_valve_regurgitation1.43663756
60MP0003136_yellow_coat_color1.42963389
61MP0003941_abnormal_skin_development1.41747628
62MP0001485_abnormal_pinna_reflex1.40042036
63MP0000631_abnormal_neuroendocrine_gland1.38575598
64MP0003984_embryonic_growth_retardation1.37493488
65MP0001486_abnormal_startle_reflex1.37187336
66MP0003195_calcinosis1.36976616
67MP0000566_synostosis1.34992726
68MP0003938_abnormal_ear_development1.33930040
69MP0008789_abnormal_olfactory_epithelium1.33300924
70MP0002233_abnormal_nose_morphology1.33145336
71MP0002088_abnormal_embryonic_growth/wei1.32813540
72MP0001286_abnormal_eye_development1.31266596
73MP0000350_abnormal_cell_proliferation1.31203888
74MP0005646_abnormal_pituitary_gland1.31172526
75MP0008007_abnormal_cellular_replicative1.30576187
76MP0006138_congestive_heart_failure1.28438667
77MP0010307_abnormal_tumor_latency1.27411818
78MP0005248_abnormal_Harderian_gland1.27037497
79MP0000747_muscle_weakness1.26214072
80MP0003221_abnormal_cardiomyocyte_apopto1.25545099
81MP0003828_pulmonary_edema1.23988043
82MP0002108_abnormal_muscle_morphology1.23318723
83MP0004147_increased_porphyrin_level1.23129036
84MP0005423_abnormal_somatic_nervous1.22121976
85MP0009250_abnormal_appendicular_skeleto1.20565059
86MP0009053_abnormal_anal_canal1.19423654
87MP0005253_abnormal_eye_physiology1.18877265
88MP0010368_abnormal_lymphatic_system1.16416510
89MP0000516_abnormal_urinary_system1.15882880
90MP0005367_renal/urinary_system_phenotyp1.15882880
91MP0000428_abnormal_craniofacial_morphol1.15758284
92MP0004272_abnormal_basement_membrane1.15585921
93MP0002210_abnormal_sex_determination1.14370322
94MP0006072_abnormal_retinal_apoptosis1.13381138
95MP0003315_abnormal_perineum_morphology1.13095838
96MP0005330_cardiomyopathy1.12908384
97MP0002272_abnormal_nervous_system1.12688170
98MP0008877_abnormal_DNA_methylation1.11822171
99MP0003861_abnormal_nervous_system1.11395631
100MP0003385_abnormal_body_wall1.11056923
101MP0001697_abnormal_embryo_size1.10818304
102MP0002557_abnormal_social/conspecific_i1.09496641
103MP0002751_abnormal_autonomic_nervous1.09079258
104MP0004270_analgesia1.07438946
105MP0002734_abnormal_mechanical_nocicepti1.06414580
106MP0002396_abnormal_hematopoietic_system1.05668543
107MP0002653_abnormal_ependyma_morphology1.05295607
108MP0002080_prenatal_lethality1.04158092
109MP0003646_muscle_fatigue1.04145182
110MP0005391_vision/eye_phenotype1.03867213
111MP0002111_abnormal_tail_morphology1.03477537
112MP0003705_abnormal_hypodermis_morpholog1.02975153
113MP0002060_abnormal_skin_morphology1.02091399
114MP0002822_catalepsy1.02016014
115MP0002085_abnormal_embryonic_tissue1.01108939
116MP0009046_muscle_twitch1.00876953
117MP0003942_abnormal_urinary_system0.99461732
118MP0001756_abnormal_urination0.99174610
119MP0009333_abnormal_splenocyte_physiolog0.98848427
120MP0002752_abnormal_somatic_nervous0.98836214
121MP0003937_abnormal_limbs/digits/tail_de0.98041963
122MP0001929_abnormal_gametogenesis0.97469183
123MP0000955_abnormal_spinal_cord0.96623283
124MP0002152_abnormal_brain_morphology0.96374012
125MP0000653_abnormal_sex_gland0.96243052
126MP0005195_abnormal_posterior_eye0.96011268
127MP0001145_abnormal_male_reproductive0.95643528
128MP0002638_abnormal_pupillary_reflex0.94870153
129MP0009745_abnormal_behavioral_response0.94738537
130MP0003279_aneurysm0.94422104
131MP0002269_muscular_atrophy0.93162713
132MP0002184_abnormal_innervation0.92731111
133MP0000026_abnormal_inner_ear0.92316024
134MP0001299_abnormal_eye_distance/0.91519052
135MP0003635_abnormal_synaptic_transmissio0.90946970
136MP0002736_abnormal_nociception_after0.90838339
137MP0004859_abnormal_synaptic_plasticity0.90400262
138MP0002086_abnormal_extraembryonic_tissu0.89969356
139MP0001968_abnormal_touch/_nociception0.89362075
140MP0004215_abnormal_myocardial_fiber0.87840711
141MP0001963_abnormal_hearing_physiology0.87370540
142MP0002109_abnormal_limb_morphology0.86564879
143MP0001119_abnormal_female_reproductive0.84630661
144MP0003699_abnormal_female_reproductive0.84586123
145MP0002572_abnormal_emotion/affect_behav0.84482189
146MP0004197_abnormal_fetal_growth/weight/0.83693550
147MP0003698_abnormal_male_reproductive0.83281336
148MP0000733_abnormal_muscle_development0.82947206
149MP0004142_abnormal_muscle_tone0.82354634
150MP0008995_early_reproductive_senescence0.81846440
151MP0002882_abnormal_neuron_morphology0.81764753
152MP0002127_abnormal_cardiovascular_syste0.81389554
153MP0000383_abnormal_hair_follicle0.80981651
154MP0002063_abnormal_learning/memory/cond0.80874554
155MP0009672_abnormal_birth_weight0.79542489
156MP0000647_abnormal_sebaceous_gland0.78639235
157MP0000751_myopathy0.78301233
158MP0001545_abnormal_hematopoietic_system0.76981230
159MP0005397_hematopoietic_system_phenotyp0.76981230
160MP0002938_white_spotting0.76351664
161MP0002092_abnormal_eye_morphology0.76106121
162MP0000767_abnormal_smooth_muscle0.75378917
163MP0002084_abnormal_developmental_patter0.74338086
164MP0003115_abnormal_respiratory_system0.73246008
165MP0004145_abnormal_muscle_electrophysio0.73035722
166MP0004036_abnormal_muscle_relaxation0.70742207
167MP0003755_abnormal_palate_morphology0.70741798
168MP0005389_reproductive_system_phenotype0.70048377
169MP0003656_abnormal_erythrocyte_physiolo0.69367513
170MP0000013_abnormal_adipose_tissue0.69249187
171MP0005621_abnormal_cell_physiology0.67526766
172MP0000432_abnormal_head_morphology0.67458545
173MP0009703_decreased_birth_body0.67208061
174MP0003935_abnormal_craniofacial_develop0.65800175
175MP0005369_muscle_phenotype0.65380541
176MP0002160_abnormal_reproductive_system0.65041117
177MP0000534_abnormal_ureter_morphology0.64860992
178MP0004019_abnormal_vitamin_homeostasis0.62861407
179MP0000627_abnormal_mammary_gland0.62594372

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.89000981
2Hyperglycinemia (HP:0002154)4.86763696
3Breast hypoplasia (HP:0003187)4.76783610
4Birth length less than 3rd percentile (HP:0003561)4.60176186
5Impulsivity (HP:0100710)4.56544138
6Ankle contracture (HP:0006466)4.55614423
7Ureteral duplication (HP:0000073)4.25063434
8Hyperglycinuria (HP:0003108)4.01487957
9Muscle fiber splitting (HP:0003555)4.01245849
10Abnormality of the umbilical cord (HP:0010881)3.95277792
11Bundle branch block (HP:0011710)3.88562415
12Entropion (HP:0000621)3.80451129
13Carpal bone hypoplasia (HP:0001498)3.70195065
14Protrusio acetabuli (HP:0003179)3.69355483
15Short nail (HP:0001799)3.54538739
16Atrioventricular block (HP:0001678)3.47432092
17Rough bone trabeculation (HP:0100670)3.34591324
18Volvulus (HP:0002580)3.30912593
19Abnormality of glycine metabolism (HP:0010895)3.29587087
20Abnormality of serine family amino acid metabolism (HP:0010894)3.29587087
21True hermaphroditism (HP:0010459)3.26994153
22Cerebral hypomyelination (HP:0006808)3.23470503
23Osteolytic defects of the hand bones (HP:0009699)3.23179542
24Osteolytic defects of the phalanges of the hand (HP:0009771)3.23179542
25Patent foramen ovale (HP:0001655)3.18615233
26Congenital, generalized hypertrichosis (HP:0004540)3.07429905
27Abnormality of the distal phalanges of the toes (HP:0010182)3.02601916
28Chronic hepatic failure (HP:0100626)2.98055683
29Disproportionate short-trunk short stature (HP:0003521)2.97293680
30Molar tooth sign on MRI (HP:0002419)2.96608407
31Abnormality of midbrain morphology (HP:0002418)2.96608407
32Abnormal spermatogenesis (HP:0008669)2.96349634
33Aplasia/Hypoplasia of the patella (HP:0006498)2.94743215
34Wrist flexion contracture (HP:0001239)2.91872762
35Ventricular fibrillation (HP:0001663)2.90785173
36Patellar aplasia (HP:0006443)2.90161102
37Pancreatic cysts (HP:0001737)2.88402952
38Premature ovarian failure (HP:0008209)2.87927597
39Intestinal atresia (HP:0011100)2.87658396
40Gout (HP:0001997)2.86147313
41Nephronophthisis (HP:0000090)2.85277142
42Submucous cleft hard palate (HP:0000176)2.84688691
43Reduced subcutaneous adipose tissue (HP:0003758)2.80256305
44Soft skin (HP:0000977)2.79947147
45Abnormality of serum amino acid levels (HP:0003112)2.78364752
46Secondary amenorrhea (HP:0000869)2.76777303
47Hyperglycemia (HP:0003074)2.74540835
48Supernumerary spleens (HP:0009799)2.74413969
49Myelomeningocele (HP:0002475)2.74194889
50Azoospermia (HP:0000027)2.73237503
51Abnormality of the ileum (HP:0001549)2.72133702
52Bifid tongue (HP:0010297)2.71915893
53Glucose intolerance (HP:0000833)2.71028741
54Embryonal renal neoplasm (HP:0011794)2.70617271
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.62198034
56Tubulointerstitial nephritis (HP:0001970)2.60837294
57Insulin-resistant diabetes mellitus (HP:0000831)2.57255898
58Septo-optic dysplasia (HP:0100842)2.56937597
59Meckel diverticulum (HP:0002245)2.55261547
60Enlarged kidneys (HP:0000105)2.51282718
61Anophthalmia (HP:0000528)2.50149526
62Areflexia of lower limbs (HP:0002522)2.49924359
63Heart block (HP:0012722)2.49823951
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49715446
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48115250
66Abnormality of alanine metabolism (HP:0010916)2.48115250
67Hyperalaninemia (HP:0003348)2.48115250
68Tetraplegia (HP:0002445)2.45179049
69Alopecia of scalp (HP:0002293)2.44235008
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44046258
71Abnormal atrioventricular conduction (HP:0005150)2.42874198
72Difficulty climbing stairs (HP:0003551)2.42722099
73Male infertility (HP:0003251)2.42680925
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42147156
75Short clavicles (HP:0000894)2.42118345
76Abnormal delivery (HP:0001787)2.41534336
77Abnormality of the aortic arch (HP:0012303)2.41510130
78Abnormal trabecular bone morphology (HP:0100671)2.41044108
79Capillary hemangiomas (HP:0005306)2.37117748
80Abnormality of the labia minora (HP:0012880)2.36777198
81Progressive muscle weakness (HP:0003323)2.32485167
82Hyperventilation (HP:0002883)2.31875526
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.31772999
84Oligodactyly (hands) (HP:0001180)2.31444601
85Sparse lateral eyebrow (HP:0005338)2.31367791
86Stillbirth (HP:0003826)2.30303840
87Medial flaring of the eyebrow (HP:0010747)2.30140446
88Optic nerve hypoplasia (HP:0000609)2.28625674
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28415791
90Missing ribs (HP:0000921)2.28308218
91Abnormality of the renal medulla (HP:0100957)2.28059307
92Vaginal atresia (HP:0000148)2.27435778
93Shallow orbits (HP:0000586)2.26396006
94Abnormalities of placenta or umbilical cord (HP:0001194)2.25539853
95Drooling (HP:0002307)2.24924096
96Colon cancer (HP:0003003)2.24834282
97Genital tract atresia (HP:0001827)2.24339785
98Gait imbalance (HP:0002141)2.23851013
99Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23464225
100Triphalangeal thumb (HP:0001199)2.23254726
101Absent hand (HP:0004050)2.22495704
102Natal tooth (HP:0000695)2.20961573
103Segmental peripheral demyelination/remyelination (HP:0003481)2.20813702
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19984095
105Bell-shaped thorax (HP:0001591)2.18814856
106Chromsome breakage (HP:0040012)2.18640936
107Abnormality of chromosome stability (HP:0003220)2.18465145
108Congenital primary aphakia (HP:0007707)2.18128774
109Pustule (HP:0200039)2.16957258
110Male pseudohermaphroditism (HP:0000037)2.15881490
111Biconcave vertebral bodies (HP:0004586)2.13697627
112Absent radius (HP:0003974)2.12561329
113Multiple enchondromatosis (HP:0005701)2.11056652
114Preaxial foot polydactyly (HP:0001841)2.10735521
115Cystic liver disease (HP:0006706)2.10002660
116Gonadotropin excess (HP:0000837)2.09580688
117Sparse eyelashes (HP:0000653)2.09398655
118Gastrointestinal atresia (HP:0002589)2.08957215
119Postaxial foot polydactyly (HP:0001830)2.08691119
120Aortic valve stenosis (HP:0001650)2.07906013
121Aplasia/Hypoplasia of the clavicles (HP:0006710)2.07036290
122Prolonged neonatal jaundice (HP:0006579)2.06505551
123Adrenal hypoplasia (HP:0000835)2.05590414
124Pancreatic fibrosis (HP:0100732)2.04303353
125Aplasia/Hypoplasia of the tongue (HP:0010295)2.03903685
126Follicular hyperkeratosis (HP:0007502)2.03879886
127Irregular epiphyses (HP:0010582)2.03077540
128Occipital encephalocele (HP:0002085)2.02702863
129Nephrogenic diabetes insipidus (HP:0009806)2.02548635
130Oligodactyly (HP:0012165)2.01701358
131Narrow forehead (HP:0000341)1.98696631
132Cervical subluxation (HP:0003308)1.98657359
133Vitreoretinal degeneration (HP:0000655)1.98139078
134Death in infancy (HP:0001522)1.97930841
135Anencephaly (HP:0002323)1.97719711
136Atonic seizures (HP:0010819)1.97360144
137Excessive salivation (HP:0003781)1.96931884
138Testicular atrophy (HP:0000029)1.96651961
139Poor coordination (HP:0002370)1.96194981
140Shawl scrotum (HP:0000049)1.95038993
141Sclerocornea (HP:0000647)1.95017237
142Aplasia involving forearm bones (HP:0009822)1.94689372
143Absent forearm bone (HP:0003953)1.94689372
144Abnormality of the anterior horn cell (HP:0006802)1.94148142
145Degeneration of anterior horn cells (HP:0002398)1.94148142
146Focal motor seizures (HP:0011153)1.93762047
147Small epiphyses (HP:0010585)1.93012235
148Abnormality of the proximal phalanges of the hand (HP:0009834)1.92888448
149Tracheomalacia (HP:0002779)1.91875403
150Duodenal stenosis (HP:0100867)1.91648741
151Small intestinal stenosis (HP:0012848)1.91648741
152Oligohydramnios (HP:0001562)1.91371827
153Flat capital femoral epiphysis (HP:0003370)1.90222446
154Postaxial hand polydactyly (HP:0001162)1.89975178
155Abnormality of subcutaneous fat tissue (HP:0001001)1.89927806
156Short tibia (HP:0005736)1.89522994
157Preaxial hand polydactyly (HP:0001177)1.88632937
158Abnormality of the duodenum (HP:0002246)1.87597185
159Aplasia/Hypoplasia of the hallux (HP:0008362)1.86708970
160Abnormality of the middle phalanges of the toes (HP:0010183)1.86337759
161Pelvic girdle muscle weakness (HP:0003749)1.86251368
162Congenital hepatic fibrosis (HP:0002612)1.85303553
163Megaloblastic anemia (HP:0001889)1.84597341
164Tubular atrophy (HP:0000092)1.84343548
165Absent epiphyses (HP:0010577)1.84319025
166Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84319025
167Abnormal lung lobation (HP:0002101)1.84189927
168Midline defect of the nose (HP:0004122)1.83710214
169Renal hypoplasia (HP:0000089)1.82199432
170Deformed tarsal bones (HP:0008119)1.82176123
171Labial hypoplasia (HP:0000066)1.80575048
172Bilateral microphthalmos (HP:0007633)1.80268440
173Esophageal atresia (HP:0002032)1.79841232
174Astigmatism (HP:0000483)1.77505295
175Aqueductal stenosis (HP:0002410)1.76026559
176Pancreatic islet-cell hyperplasia (HP:0004510)1.75896321
177Oculomotor apraxia (HP:0000657)1.75379158
178Abnormality of the lumbar spine (HP:0100712)1.74068386
179Thyroid-stimulating hormone excess (HP:0002925)1.73926716
180Meningocele (HP:0002435)1.73257483
181Cutaneous finger syndactyly (HP:0010554)1.73039705
182Febrile seizures (HP:0002373)1.72634794
183Cortical dysplasia (HP:0002539)1.72535674
184Focal seizures (HP:0007359)1.72184296
185Aganglionic megacolon (HP:0002251)1.71620327
186Abdominal situs inversus (HP:0003363)1.71290710
187Abnormality of abdominal situs (HP:0011620)1.71290710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.12695763
2WEE14.32782459
3AKT33.79341138
4BMPR1B3.68397378
5TNIK3.49773784
6PLK43.31894432
7NEK22.88792376
8CASK2.85954799
9TSSK62.83419758
10EPHA42.73341480
11EIF2AK12.66048917
12STK38L2.53439882
13PDK42.51076267
14PDK32.51076267
15BRSK22.45034274
16ZAK2.40531724
17STK32.25814187
18MKNK22.22987268
19TTK2.10730781
20BCR2.08686107
21PNCK2.08111943
22PDK22.06762701
23LATS22.04719515
24LATS12.02964907
25TGFBR12.02890192
26EPHA22.02403188
27MAP3K42.01715814
28PLK32.00101129
29STK161.94468700
30MAPK131.86937453
31PLK11.82297821
32NME21.76439401
33TRIM281.68896993
34EPHB21.64767448
35PINK11.60783609
36DYRK31.57817740
37ACVR1B1.57336476
38PKN21.55766474
39MAP4K21.52070951
40BRSK11.50231896
41PRKD31.48668176
42FLT31.47480416
43MKNK11.41981028
44SRPK11.41418613
45PLK21.39761849
46STK241.35882638
47ADRBK21.34313147
48MAP2K71.31970626
49CHEK21.29990591
50NUAK11.27484370
51NEK11.25174605
52FGFR21.19770979
53CCNB11.17444795
54EIF2AK31.15161910
55BRD41.13505196
56RPS6KA41.11851738
57AURKB1.09769726
58MARK11.08170236
59BRAF1.06420981
60CAMK1G1.05008033
61NLK1.03725730
62WNK41.02253006
63INSRR1.02112103
64IRAK31.01112028
65DDR20.98592923
66ERBB30.97244712
67STK390.96582387
68GRK10.94078974
69ARAF0.93876829
70CDK70.91415168
71AURKA0.90483393
72NTRK30.87968637
73FGFR10.87025617
74ADRBK10.86652839
75EIF2AK20.80695137
76PRKCE0.79683592
77ALK0.79397636
78NTRK20.76380890
79PDGFRA0.76252616
80CAMK1D0.74345108
81CDK30.73776459
82WNK30.71811070
83MELK0.68113234
84OXSR10.67919538
85CHEK10.65150179
86TLK10.64224687
87PAK10.63284131
88MINK10.62768512
89PRKAA10.62634773
90TYRO30.61855150
91CDC70.60203510
92CDK40.60200090
93PRKCI0.55869259
94PAK20.55320642
95MAP2K40.54458068
96MAP3K80.54354765
97CDK190.53003245
98STK380.52813870
99CAMK2A0.50143180
100DYRK1A0.49870849
101TIE10.48109992
102CDK20.47702237
103CSNK1G10.47538943
104CSNK1A1L0.46150532
105VRK10.45435362
106FRK0.44311552
107PRKACB0.43961193
108CSNK1G30.42878300
109PIM20.42046122
110CAMK10.41829098
111SGK20.41378320
112ATR0.40085125
113ABL20.39877553
114MAP3K100.39273359
115MAP2K20.39074801
116CSNK1E0.38840686
117NEK90.38581564
118CAMKK20.38252984
119CDK10.38176873
120MTOR0.37981698
121TAF10.37767842
122CAMK40.36698520
123TNK20.32829880
124TAOK10.32666794
125PKN10.31784873
126CSNK2A10.31633039
127PRKACA0.31200551
128NEK60.31061051
129PAK30.30549525
130PRKG10.30316097
131SGK4940.29918667
132SGK2230.29918667
133CDK50.29072736
134STK40.27613195
135ATM0.27410685
136PRKCG0.25871185
137CSNK1A10.25209301
138MARK30.25144763
139CSNK2A20.23856680
140RAF10.23457468
141TTN0.21958821
142FER0.21493145
143CSNK1G20.20249306
144CDK80.19630503
145PRKAA20.19288194
146PDGFRB0.16596310
147PIM10.16521187
148MAPK100.15871205
149RPS6KA50.13848941
150OBSCN0.13231098
151DYRK20.12451125
152BCKDK0.12110533
153TGFBR20.11900577
154MAP3K50.11717049

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.89614405
2RNA polymerase_Homo sapiens_hsa030204.22000819
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21950550
4RNA transport_Homo sapiens_hsa030133.08993283
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96310639
6Regulation of autophagy_Homo sapiens_hsa041402.93022533
7Proteasome_Homo sapiens_hsa030502.86130669
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.85347220
9Cell cycle_Homo sapiens_hsa041102.58614665
10Steroid biosynthesis_Homo sapiens_hsa001002.37526874
11Vitamin digestion and absorption_Homo sapiens_hsa049772.35992908
12Folate biosynthesis_Homo sapiens_hsa007902.35255471
13Protein export_Homo sapiens_hsa030602.26273317
14Basal transcription factors_Homo sapiens_hsa030222.22894513
15Nicotine addiction_Homo sapiens_hsa050332.21479117
16Pyrimidine metabolism_Homo sapiens_hsa002402.06816521
17Basal cell carcinoma_Homo sapiens_hsa052172.06283665
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04420641
19Glycerophospholipid metabolism_Homo sapiens_hsa005642.03691046
20p53 signaling pathway_Homo sapiens_hsa041152.00224668
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91325545
22Spliceosome_Homo sapiens_hsa030401.87409895
23Propanoate metabolism_Homo sapiens_hsa006401.85553345
24Phototransduction_Homo sapiens_hsa047441.71319585
25Purine metabolism_Homo sapiens_hsa002301.68637510
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.57786022
27Homologous recombination_Homo sapiens_hsa034401.57529849
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54517908
29Base excision repair_Homo sapiens_hsa034101.53859820
30Pentose phosphate pathway_Homo sapiens_hsa000301.47092661
31DNA replication_Homo sapiens_hsa030301.44408609
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40148039
33Nucleotide excision repair_Homo sapiens_hsa034201.38224840
34Nitrogen metabolism_Homo sapiens_hsa009101.37501886
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37352661
36Oocyte meiosis_Homo sapiens_hsa041141.37330228
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33475872
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31998297
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29736835
40Non-homologous end-joining_Homo sapiens_hsa034501.29594163
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27169166
42Circadian rhythm_Homo sapiens_hsa047101.24963438
43Taste transduction_Homo sapiens_hsa047421.24459125
44Oxidative phosphorylation_Homo sapiens_hsa001901.24125640
45Fanconi anemia pathway_Homo sapiens_hsa034601.23952215
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20537392
47Parkinsons disease_Homo sapiens_hsa050121.18548497
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15734018
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.14067533
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.10983644
51Mismatch repair_Homo sapiens_hsa034301.06429466
52Wnt signaling pathway_Homo sapiens_hsa043101.05217803
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03463695
54Fatty acid degradation_Homo sapiens_hsa000711.02722194
55GABAergic synapse_Homo sapiens_hsa047271.02492657
56Epstein-Barr virus infection_Homo sapiens_hsa051691.01974331
57RNA degradation_Homo sapiens_hsa030181.01077811
58Circadian entrainment_Homo sapiens_hsa047131.00835563
59Axon guidance_Homo sapiens_hsa043600.98604242
60Peroxisome_Homo sapiens_hsa041460.96831576
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96392559
62Glutamatergic synapse_Homo sapiens_hsa047240.96108358
63Huntingtons disease_Homo sapiens_hsa050160.93487378
64Morphine addiction_Homo sapiens_hsa050320.93354924
65Cardiac muscle contraction_Homo sapiens_hsa042600.92850957
66Olfactory transduction_Homo sapiens_hsa047400.92827993
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91328874
68Tryptophan metabolism_Homo sapiens_hsa003800.88759173
69Fatty acid biosynthesis_Homo sapiens_hsa000610.85148977
70Pyruvate metabolism_Homo sapiens_hsa006200.84508571
71ECM-receptor interaction_Homo sapiens_hsa045120.83682106
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79226026
73Biosynthesis of amino acids_Homo sapiens_hsa012300.78217422
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75806020
75Cocaine addiction_Homo sapiens_hsa050300.75306056
76Fructose and mannose metabolism_Homo sapiens_hsa000510.74424088
77Fat digestion and absorption_Homo sapiens_hsa049750.73909140
78mRNA surveillance pathway_Homo sapiens_hsa030150.73863169
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.73847312
80Dopaminergic synapse_Homo sapiens_hsa047280.72775286
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66783730
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66374996
83Arachidonic acid metabolism_Homo sapiens_hsa005900.65397110
84TGF-beta signaling pathway_Homo sapiens_hsa043500.65324459
85FoxO signaling pathway_Homo sapiens_hsa040680.64240746
86Fatty acid elongation_Homo sapiens_hsa000620.63952357
87Alzheimers disease_Homo sapiens_hsa050100.63571215
88Lysine degradation_Homo sapiens_hsa003100.63513875
89Small cell lung cancer_Homo sapiens_hsa052220.63414350
90Melanogenesis_Homo sapiens_hsa049160.61603403
91Hippo signaling pathway_Homo sapiens_hsa043900.61328249
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59137734
93Arginine and proline metabolism_Homo sapiens_hsa003300.58598603
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58304963
95Serotonergic synapse_Homo sapiens_hsa047260.58205817
96Hedgehog signaling pathway_Homo sapiens_hsa043400.57523722
97Protein digestion and absorption_Homo sapiens_hsa049740.57033807
98Glutathione metabolism_Homo sapiens_hsa004800.55435091
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53945923
100Renin-angiotensin system_Homo sapiens_hsa046140.52836135
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.52546336
102Glycerolipid metabolism_Homo sapiens_hsa005610.52507219
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51536281
104Lysosome_Homo sapiens_hsa041420.51276240
105Sphingolipid metabolism_Homo sapiens_hsa006000.50838109
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48264714
107Chemical carcinogenesis_Homo sapiens_hsa052040.48240151
108Insulin secretion_Homo sapiens_hsa049110.47498935
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47406016
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47274586
111Mineral absorption_Homo sapiens_hsa049780.47177221
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46933454
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46739773
114mTOR signaling pathway_Homo sapiens_hsa041500.46378043
115Caffeine metabolism_Homo sapiens_hsa002320.46051879
116MicroRNAs in cancer_Homo sapiens_hsa052060.45657697
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42781885
118beta-Alanine metabolism_Homo sapiens_hsa004100.42456078
119Linoleic acid metabolism_Homo sapiens_hsa005910.41833891
120Carbon metabolism_Homo sapiens_hsa012000.41510148
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40143399
122Metabolic pathways_Homo sapiens_hsa011000.39823478
123Prostate cancer_Homo sapiens_hsa052150.36467617
124Selenocompound metabolism_Homo sapiens_hsa004500.35014922
125Inositol phosphate metabolism_Homo sapiens_hsa005620.34745191
126Antigen processing and presentation_Homo sapiens_hsa046120.34227793
127Retinol metabolism_Homo sapiens_hsa008300.34208788
128Ribosome_Homo sapiens_hsa030100.34053731
129Renal cell carcinoma_Homo sapiens_hsa052110.29735822
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29271058
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28583673
132HTLV-I infection_Homo sapiens_hsa051660.25877204
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24740335
134Ovarian steroidogenesis_Homo sapiens_hsa049130.23948363
135Herpes simplex infection_Homo sapiens_hsa051680.22855391
136Galactose metabolism_Homo sapiens_hsa000520.22854079
137Focal adhesion_Homo sapiens_hsa045100.22820055
138Sulfur relay system_Homo sapiens_hsa041220.22649982
139One carbon pool by folate_Homo sapiens_hsa006700.21878875
140AMPK signaling pathway_Homo sapiens_hsa041520.20859822
141Tight junction_Homo sapiens_hsa045300.20018212
142HIF-1 signaling pathway_Homo sapiens_hsa040660.19817581
143Viral carcinogenesis_Homo sapiens_hsa052030.19304883
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19145953
145Adherens junction_Homo sapiens_hsa045200.18438495
146Butanoate metabolism_Homo sapiens_hsa006500.17724445
147Prion diseases_Homo sapiens_hsa050200.17552413
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17510128
149Pathways in cancer_Homo sapiens_hsa052000.16812904
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14747039
151Amoebiasis_Homo sapiens_hsa051460.14179980
152Dilated cardiomyopathy_Homo sapiens_hsa054140.13912557
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12078345
154Fatty acid metabolism_Homo sapiens_hsa012120.11076906
155Ether lipid metabolism_Homo sapiens_hsa005650.10880422

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