NAALADL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of bile acid biosynthetic process (GO:0070857)8.29228070
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.11292097
3bile acid and bile salt transport (GO:0015721)8.08717688
4adhesion of symbiont to host cell (GO:0044650)7.42345263
5virion attachment to host cell (GO:0019062)7.42345263
6regulation of guanylate cyclase activity (GO:0031282)7.34953854
7NADH metabolic process (GO:0006734)7.21234110
8actin filament depolymerization (GO:0030042)6.72933411
9fat-soluble vitamin biosynthetic process (GO:0042362)6.43087613
10epoxygenase P450 pathway (GO:0019373)6.30172657
11adhesion of symbiont to host (GO:0044406)6.01496762
12fructose metabolic process (GO:0006000)5.57624396
13positive regulation of guanylate cyclase activity (GO:0031284)5.52811369
14digestive system process (GO:0022600)5.52208393
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.51171851
16modified amino acid transport (GO:0072337)5.38433257
17vitamin A metabolic process (GO:0006776)5.35306323
18drug catabolic process (GO:0042737)5.35269667
19cellular response to hepatocyte growth factor stimulus (GO:0035729)5.28338633
20response to hepatocyte growth factor (GO:0035728)5.28338633
21UDP-N-acetylglucosamine metabolic process (GO:0006047)5.26387890
22defense response to fungus (GO:0050832)5.16795226
23killing of cells of other organism (GO:0031640)5.11680435
24disruption of cells of other organism (GO:0044364)5.11680435
25glucose 6-phosphate metabolic process (GO:0051156)4.90097473
26regulation of triglyceride catabolic process (GO:0010896)4.88314236
27peptide hormone processing (GO:0016486)4.83752718
28lipoprotein metabolic process (GO:0042157)4.82827519
29drinking behavior (GO:0042756)4.80717455
30regulation of cellular extravasation (GO:0002691)4.74816092
31drug metabolic process (GO:0017144)4.67995731
32regulation of cGMP biosynthetic process (GO:0030826)4.66501712
33receptor guanylyl cyclase signaling pathway (GO:0007168)4.60908494
34lipoprotein transport (GO:0042953)4.58469949
35thyroid hormone metabolic process (GO:0042403)4.56344812
36antibacterial humoral response (GO:0019731)4.55006374
37sulfate transmembrane transport (GO:1902358)4.53614671
38antimicrobial humoral response (GO:0019730)4.48318178
39sulfur compound transport (GO:0072348)4.41970115
40diacylglycerol metabolic process (GO:0046339)4.29708958
41phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.26261401
42plasma lipoprotein particle assembly (GO:0034377)4.25480486
43maintenance of gastrointestinal epithelium (GO:0030277)4.21189764
44digestion (GO:0007586)4.20491750
45protein-lipid complex assembly (GO:0065005)4.18987109
46regulation of cholesterol homeostasis (GO:2000188)4.12905123
47very-low-density lipoprotein particle assembly (GO:0034379)4.06179134
48intestinal epithelial cell development (GO:0060576)4.05042131
49cellular response to nitric oxide (GO:0071732)3.95966683
50cholesterol homeostasis (GO:0042632)3.93969209
51renal system process involved in regulation of blood volume (GO:0001977)3.91245479
52urea cycle (GO:0000050)3.91006499
53sterol homeostasis (GO:0055092)3.90265973
54antigen processing and presentation of endogenous antigen (GO:0019883)3.89959079
55regulation of cGMP metabolic process (GO:0030823)3.83784758
56regulation of vitamin metabolic process (GO:0030656)3.82657927
57flavonoid metabolic process (GO:0009812)3.80019022
58purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.79457433
593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.79457433
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79404983
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77985376
62cholesterol efflux (GO:0033344)3.75031949
63regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.73928511
64endocrine process (GO:0050886)3.73928511
65regulation of systemic arterial blood pressure by hormone (GO:0001990)3.73928511
66urea metabolic process (GO:0019627)3.72606955
67O-glycan processing (GO:0016266)3.72432719
68response to nitric oxide (GO:0071731)3.71400616
69cholesterol transport (GO:0030301)3.70139618
70sterol transport (GO:0015918)3.70139618
71sulfate transport (GO:0008272)3.67847109
72vitamin transmembrane transport (GO:0035461)3.67045089
73phospholipid efflux (GO:0033700)3.66081514
74glycolipid catabolic process (GO:0019377)3.63586349
75alkaloid metabolic process (GO:0009820)3.62069739
76regulation of actin nucleation (GO:0051125)3.61545748
77regulation of cholesterol esterification (GO:0010872)3.61169951
78negative regulation of sterol transport (GO:0032372)3.60964955
79negative regulation of cholesterol transport (GO:0032375)3.60964955
80glycosphingolipid catabolic process (GO:0046479)3.57791549
81nitrogen cycle metabolic process (GO:0071941)3.57595643
82neutral amino acid transport (GO:0015804)3.52879516
83uronic acid metabolic process (GO:0006063)3.49832782
84glucuronate metabolic process (GO:0019585)3.49832782
85cellular response to reactive nitrogen species (GO:1902170)3.47992004
86peptide catabolic process (GO:0043171)3.47216239
87cellular glucuronidation (GO:0052695)3.43270327
88hormone catabolic process (GO:0042447)3.43063982
89positive regulation of cGMP biosynthetic process (GO:0030828)3.40278408
90hepatocyte apoptotic process (GO:0097284)3.39883443
91leukotriene metabolic process (GO:0006691)3.39463950
92negative regulation of sodium ion transport (GO:0010766)3.39289864
93epithelial structure maintenance (GO:0010669)3.37881899
94cGMP biosynthetic process (GO:0006182)3.37096779
95phospholipid homeostasis (GO:0055091)3.36303649
96positive regulation of triglyceride lipase activity (GO:0061365)3.35150396
97positive regulation of lipoprotein lipase activity (GO:0051006)3.35150396
98negative regulation of steroid biosynthetic process (GO:0010894)3.34018837
99transepithelial transport (GO:0070633)3.29620957
100regulation of systemic arterial blood pressure (GO:0003073)3.29343913
101L-ascorbic acid metabolic process (GO:0019852)3.26562209
102fat-soluble vitamin metabolic process (GO:0006775)3.22022848
103striated muscle atrophy (GO:0014891)3.21053315
104negative regulation of steroid metabolic process (GO:0045939)3.19816993
105homocysteine metabolic process (GO:0050667)3.18359981
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17130703
107thrombin receptor signaling pathway (GO:0070493)3.16622964
108nucleoside diphosphate biosynthetic process (GO:0009133)3.15438371
109response to histamine (GO:0034776)3.14462265
110hydrogen peroxide catabolic process (GO:0042744)3.14222875
111hemidesmosome assembly (GO:0031581)3.12435950
112positive regulation of pseudopodium assembly (GO:0031274)3.10960136
113negative regulation of digestive system process (GO:0060457)3.10585927
114quinone biosynthetic process (GO:1901663)3.08924699
115filopodium assembly (GO:0046847)3.07758304
116vitamin biosynthetic process (GO:0009110)3.07089799
117transcytosis (GO:0045056)3.06580084
118exogenous drug catabolic process (GO:0042738)3.05648029
119hydrogen peroxide metabolic process (GO:0042743)3.04986737
120cytidine deamination (GO:0009972)3.04685158
121cytidine metabolic process (GO:0046087)3.04685158
122cytidine catabolic process (GO:0006216)3.04685158
123thyroid hormone generation (GO:0006590)3.04119542
124cobalamin metabolic process (GO:0009235)3.03794116
125glutamine family amino acid biosynthetic process (GO:0009084)3.03203303
126response to fungus (GO:0009620)3.01579395
127regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00592116
128sexual reproduction (GO:0019953)2.98930192
129plasma lipoprotein particle organization (GO:0071827)2.96914804
130triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96697126
131monocarboxylic acid transport (GO:0015718)2.95954018
132arachidonic acid metabolic process (GO:0019369)2.95112786
133glycerol metabolic process (GO:0006071)2.94698992
134protein kinase C signaling (GO:0070528)2.92521631
135phenol-containing compound catabolic process (GO:0019336)2.92436473
136regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92408684
137high-density lipoprotein particle remodeling (GO:0034375)2.92367517
138positive regulation of fatty acid biosynthetic process (GO:0045723)2.91151846
139positive regulation of cGMP metabolic process (GO:0030825)2.90696176
140protein-lipid complex remodeling (GO:0034368)2.90212951
141macromolecular complex remodeling (GO:0034367)2.90212951
142plasma lipoprotein particle remodeling (GO:0034369)2.90212951
143regulation of viral release from host cell (GO:1902186)2.88816877
144positive regulation of lipid catabolic process (GO:0050996)2.88056784
145renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.87828032
146ceramide catabolic process (GO:0046514)2.87728467
147activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.86170148
148bile acid metabolic process (GO:0008206)2.84187572
149bicarbonate transport (GO:0015701)2.81484406
150positive regulation of Rho protein signal transduction (GO:0035025)2.81357227
151ventricular cardiac muscle cell action potential (GO:0086005)2.80941627
152lipid homeostasis (GO:0055088)2.77732771
153skeletal muscle adaptation (GO:0043501)2.76864690
154sperm capacitation (GO:0048240)2.76650123
155vitamin transport (GO:0051180)2.75514455
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.73083140
157renal absorption (GO:0070293)2.69406084
158drug transport (GO:0015893)2.67558346
159sphingomyelin metabolic process (GO:0006684)2.65551622
160regulation of cytokine secretion involved in immune response (GO:0002739)2.65424311
161intestinal cholesterol absorption (GO:0030299)13.5709106
162angiotensin maturation (GO:0002003)12.7632292
163intestinal absorption (GO:0050892)12.3717517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.12751207
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.74471781
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.82523147
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.25298985
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.56998205
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.17299690
7GATA6_25053715_ChIP-Seq_YYC3_Human3.00237635
8GATA4_25053715_ChIP-Seq_YYC3_Human2.91337385
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.80843587
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58636445
11SOX2_20726797_ChIP-Seq_SW620_Human2.53323149
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46170327
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.28374079
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20486435
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.11338882
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.08202436
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00227396
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92036562
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91113339
20KLF5_25053715_ChIP-Seq_YYC3_Human1.86945749
21VDR_21846776_ChIP-Seq_THP-1_Human1.85109790
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.83092348
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80431063
24BCL6_27268052_Chip-Seq_Bcells_Human1.78981108
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78922907
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.75163928
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74400448
28RACK7_27058665_Chip-Seq_MCF-7_Human1.72854045
29BCOR_27268052_Chip-Seq_Bcells_Human1.72034061
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71313740
31GATA2_19941826_ChIP-Seq_K562_Human1.68948938
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67968414
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.63235876
34* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.63152097
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62845167
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61370451
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.60950030
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.60840472
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60506418
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58549540
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58265618
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57082097
43ATF3_27146783_Chip-Seq_COLON_Human1.54209713
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.53430080
45CLOCK_20551151_ChIP-Seq_293T_Human1.50659752
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50087681
47AR_21909140_ChIP-Seq_LNCAP_Human1.49404225
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47415541
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.46899741
50SA1_27219007_Chip-Seq_Bcells_Human1.45678050
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41976053
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41363503
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40737605
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40236647
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40025457
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39795623
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39623475
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39208126
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38919934
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37986539
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37074057
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36975848
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35043187
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34645969
65GATA1_19941826_ChIP-Seq_K562_Human1.33973985
66* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31314715
67CREB1_26743006_Chip-Seq_LNCaP_Human1.28643975
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26591172
69UTX_26944678_Chip-Seq_JUKART_Human1.26161567
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25949400
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25802196
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25756172
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25036813
74ZNF263_19887448_ChIP-Seq_K562_Human1.24861130
75NANOG_20526341_ChIP-Seq_ESCs_Human1.24554964
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22925072
77STAT1_20625510_ChIP-Seq_HELA_Human1.21277878
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.19481618
79MYB_26560356_Chip-Seq_TH2_Human1.19349712
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19059293
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18522335
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18505887
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17848980
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17264382
85P300_27268052_Chip-Seq_Bcells_Human1.15862305
86LXR_22292898_ChIP-Seq_THP-1_Human1.15599536
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15401227
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15360308
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13960723
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13563209
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13485187
92* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13463597
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13431537
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11967346
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11921305
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11360514
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11163588
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10963389
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10591143
100E2F1_20622854_ChIP-Seq_HELA_Human1.10187200
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09913791
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09474864
103CTCF_27219007_Chip-Seq_Bcells_Human1.09145263
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09089561
105* P68_20966046_ChIP-Seq_HELA_Human1.08819956
106MYB_26560356_Chip-Seq_TH1_Human1.07195339
107VDR_24787735_ChIP-Seq_THP-1_Human1.07180763
108* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05733660
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05325913
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.05226242
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.04563527
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.03919638
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03875056
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03866443
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02970175
116SCL_19346495_ChIP-Seq_HPC-7_Human1.01114863
117YY1_22570637_ChIP-Seq_MALME-3M_Human1.00328173
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00000104
119RUNX_20019798_ChIP-Seq_JUKART_Human0.99688926
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98875567
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97962234
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97586776
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97062290
124MAF_26560356_Chip-Seq_TH1_Human0.96850528
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.96722643
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95727939
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95727939
128CTCF_20526341_ChIP-Seq_ESCs_Human0.94920625
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94595271
130GATA1_22025678_ChIP-Seq_K562_Human0.94381407
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94219464
132DROSHA_22980978_ChIP-Seq_HELA_Human0.93950217
133ELK3_25401928_ChIP-Seq_HUVEC_Human0.93716128
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93083903
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.91605146
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90602067
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89481798
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.88151692
139TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85505441
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.84440615
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83513703
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82027274
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80717361
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80484945
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80266520
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79827343
147TP63_22573176_ChIP-Seq_HFKS_Human0.78510432
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78041616
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76426752
150VDR_24763502_ChIP-Seq_THP-1_Human0.76201355
151EGR1_19032775_ChIP-ChIP_M12_Human0.75927567
152JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75787919
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.74820590
154TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.74473920
155PHF8_20622854_ChIP-Seq_HELA_Human0.73854692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.60442790
2MP0004264_abnormal_extraembryonic_tissu4.47811939
3MP0005085_abnormal_gallbladder_physiolo4.10353180
4MP0003183_abnormal_peptide_metabolism4.00868487
5MP0010234_abnormal_vibrissa_follicle3.95981934
6MP0002139_abnormal_hepatobiliary_system2.89193648
7MP0005365_abnormal_bile_salt2.76882551
8MP0009840_abnormal_foam_cell2.66657878
9MP0000462_abnormal_digestive_system2.63705845
10MP0003866_abnormal_defecation2.57402130
11MP0003252_abnormal_bile_duct2.43325174
12MP0004147_increased_porphyrin_level2.42303163
13MP0010329_abnormal_lipoprotein_level2.33453170
14MP0002822_catalepsy2.24561854
15MP0002876_abnormal_thyroid_physiology2.19455837
16MP0010352_gastrointestinal_tract_polyps2.19162610
17MP0005084_abnormal_gallbladder_morpholo2.15932294
18MP0003705_abnormal_hypodermis_morpholog2.10658631
19MP0000537_abnormal_urethra_morphology2.07493641
20MP0000538_abnormal_urinary_bladder2.02003945
21MP0003878_abnormal_ear_physiology2.01277414
22MP0005377_hearing/vestibular/ear_phenot2.01277414
23MP0005360_urolithiasis10.9811313
24MP0008875_abnormal_xenobiotic_pharmacok1.80637872
25MP0005670_abnormal_white_adipose1.66365203
26MP0009379_abnormal_foot_pigmentation1.65716679
27MP0010155_abnormal_intestine_physiology1.64794425
28MP0003300_gastrointestinal_ulcer1.62982864
29MP0001873_stomach_inflammation1.62260369
30MP0001764_abnormal_homeostasis1.59211820
31MP0003191_abnormal_cellular_cholesterol1.53318137
32MP0001663_abnormal_digestive_system1.49377773
33MP0000477_abnormal_intestine_morphology1.48618881
34MP0001835_abnormal_antigen_presentation1.47934457
35MP0005381_digestive/alimentary_phenotyp1.46217578
36MP0004019_abnormal_vitamin_homeostasis1.43511699
37MP0003436_decreased_susceptibility_to1.41970989
38MP0001664_abnormal_digestion1.39777088
39MP0005448_abnormal_energy_balance1.35865190
40MP0000490_abnormal_crypts_of1.32770360
41MP0003718_maternal_effect1.32603966
42MP0003724_increased_susceptibility_to1.27292889
43MP0006054_spinal_hemorrhage1.25403023
44MP0002089_abnormal_postnatal_growth/wei1.25265158
45MP0001188_hyperpigmentation1.25112335
46MP0009785_altered_susceptibility_to1.24297805
47MP0003868_abnormal_feces_composition1.23013721
48MP0009643_abnormal_urine_homeostasis1.22428002
49MP0005025_abnormal_response_to1.19653268
50MP0002796_impaired_skin_barrier1.19071087
51MP0002396_abnormal_hematopoietic_system1.15670131
52MP0004270_analgesia1.14329681
53MP0003303_peritoneal_inflammation1.12903764
54MP0000465_gastrointestinal_hemorrhage1.12154499
55MP0005167_abnormal_blood-brain_barrier1.11647619
56MP0008469_abnormal_protein_level1.05445316
57MP0002254_reproductive_system_inflammat1.04859124
58MP0005535_abnormal_body_temperature1.03534888
59MP0005671_abnormal_response_to1.02433027
60MP0002971_abnormal_brown_adipose1.01614947
61MP0005332_abnormal_amino_acid1.01274352
62MP0009333_abnormal_splenocyte_physiolog1.00719290
63MP0000230_abnormal_systemic_arterial0.99487454
64MP0004782_abnormal_surfactant_physiolog0.97961396
65MP0001849_ear_inflammation0.97241598
66MP0002148_abnormal_hypersensitivity_rea0.94747727
67MP0000609_abnormal_liver_physiology0.94721932
68MP0001501_abnormal_sleep_pattern0.94695985
69MP0001800_abnormal_humoral_immune0.94216717
70MP0005310_abnormal_salivary_gland0.93757949
71MP0001790_abnormal_immune_system0.93660914
72MP0005387_immune_system_phenotype0.93660914
73MP0010678_abnormal_skin_adnexa0.93071852
74MP0005000_abnormal_immune_tolerance0.91008885
75MP0003806_abnormal_nucleotide_metabolis0.87824389
76MP0002118_abnormal_lipid_homeostasis0.87551844
77MP0001756_abnormal_urination0.87505045
78MP0004947_skin_inflammation0.85831422
79MP0002166_altered_tumor_susceptibility0.85741254
80MP0009764_decreased_sensitivity_to0.85498531
81MP0005501_abnormal_skin_physiology0.84221572
82MP0002419_abnormal_innate_immunity0.82440896
83MP0002723_abnormal_immune_serum0.82253802
84MP0006082_CNS_inflammation0.79459763
85MP0001819_abnormal_immune_cell0.78633507
86MP0000685_abnormal_immune_system0.77897961
87MP0002420_abnormal_adaptive_immunity0.77532813
88MP0005367_renal/urinary_system_phenotyp0.75940782
89MP0000516_abnormal_urinary_system0.75940782
90MP0002452_abnormal_antigen_presenting0.73955575
91MP0003453_abnormal_keratinocyte_physiol0.73188980
92MP0001533_abnormal_skeleton_physiology0.70628592
93MP0000249_abnormal_blood_vessel0.70505062
94MP0001765_abnormal_ion_homeostasis0.70423814
95MP0005666_abnormal_adipose_tissue0.70418709
96MP0002138_abnormal_hepatobiliary_system0.68916113
97MP0005166_decreased_susceptibility_to0.68734768
98MP0005334_abnormal_fat_pad0.67005769
99MP0003950_abnormal_plasma_membrane0.66356780
100MP0004043_abnormal_pH_regulation0.65989583
101MP0003283_abnormal_digestive_organ0.65119539
102MP0003763_abnormal_thymus_physiology0.64962118
103MP0008872_abnormal_physiological_respon0.64456531
104MP0005464_abnormal_platelet_physiology0.64140652
105MP0003938_abnormal_ear_development0.62393696
106MP0002098_abnormal_vibrissa_morphology0.62186853
107MP0005023_abnormal_wound_healing0.61921593
108MP0000716_abnormal_immune_system0.59877926
109MP0008260_abnormal_autophagy0.59537022
110MP0000015_abnormal_ear_pigmentation0.59388257
111MP0000467_abnormal_esophagus_morphology0.58300324
112MP0009384_cardiac_valve_regurgitation0.57108663
113MP0009053_abnormal_anal_canal0.56331129
114MP0002136_abnormal_kidney_physiology0.55309701
115MP0003879_abnormal_hair_cell0.54016721
116MP0000678_abnormal_parathyroid_gland0.52102378
117MP0001216_abnormal_epidermal_layer0.51953558
118MP0010307_abnormal_tumor_latency0.49752820
119MP0005451_abnormal_body_composition0.49729581
120MP0000604_amyloidosis0.48468426
121MP0005636_abnormal_mineral_homeostasis0.47896183
122MP0000470_abnormal_stomach_morphology0.47807708
123MP0000681_abnormal_thyroid_gland0.47788328
124MP0003329_amyloid_beta_deposits0.46658935
125MP0005319_abnormal_enzyme/_coenzyme0.46347876
126MP0009642_abnormal_blood_homeostasis0.45939708
127MP0005409_darkened_coat_color0.45490742
128MP0008873_increased_physiological_sensi0.42358807
129MP0001191_abnormal_skin_condition0.40862744
130MP0003315_abnormal_perineum_morphology0.40455224
131MP0005266_abnormal_metabolism0.40299338
132MP0000377_abnormal_hair_follicle0.39226783
133MP0009115_abnormal_fat_cell0.38979335
134MP0005584_abnormal_enzyme/coenzyme_acti0.38033249
135MP0005076_abnormal_cell_differentiation0.37311734
136MP0006138_congestive_heart_failure0.37179295
137MP0005174_abnormal_tail_pigmentation0.34033799
138MP0001881_abnormal_mammary_gland0.33278930
139MP0004858_abnormal_nervous_system0.32219501
140MP0003119_abnormal_digestive_system0.31394048
141MP0003638_abnormal_response/metabolism_0.31056681
142MP0001845_abnormal_inflammatory_respons0.28915517
143MP0000427_abnormal_hair_cycle0.27192380
144MP0003091_abnormal_cell_migration0.27159324

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.98248739
2Ileus (HP:0002595)7.95985289
3Hydroxyprolinuria (HP:0003080)6.47505558
4Abnormality of proline metabolism (HP:0010907)6.47505558
5Right ventricular cardiomyopathy (HP:0011663)6.23241671
6Malnutrition (HP:0004395)5.71303572
7Acanthocytosis (HP:0001927)5.66725089
8Hypobetalipoproteinemia (HP:0003563)5.28536337
9Chronic diarrhea (HP:0002028)4.86196078
10Fat malabsorption (HP:0002630)4.80853391
11Conjugated hyperbilirubinemia (HP:0002908)4.57654401
12Abnormality of the vitamin B12 metabolism (HP:0004341)3.90643216
13Hyperglycinuria (HP:0003108)3.83985585
14Systemic lupus erythematosus (HP:0002725)3.81532674
15Nausea (HP:0002018)3.72100749
16Poikilocytosis (HP:0004447)3.68662170
17Goiter (HP:0000853)3.68516316
18Autoimmune thrombocytopenia (HP:0001973)3.66483777
19Abnormality of vitamin B metabolism (HP:0004340)3.64064879
20Confusion (HP:0001289)3.61820686
21Wide cranial sutures (HP:0010537)3.58657203
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.55033950
23Abdominal distention (HP:0003270)3.46683441
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36622372
25Hypolipoproteinemia (HP:0010981)3.30910854
26Myopathic facies (HP:0002058)3.26175345
27Mildly elevated creatine phosphokinase (HP:0008180)3.21908917
28Gastrointestinal dysmotility (HP:0002579)3.16259337
29Abnormality of vitamin metabolism (HP:0100508)3.07140088
30Abnormality of monocarboxylic acid metabolism (HP:0010996)3.06975091
31Nephrolithiasis (HP:0000787)3.03704152
32Cupped ribs (HP:0000887)2.97124784
33Intrahepatic cholestasis (HP:0001406)2.96206491
34Pigmentary retinal degeneration (HP:0001146)2.95994435
35Progressive sensorineural hearing impairment (HP:0000408)2.93589806
36Hypophosphatemia (HP:0002148)2.92875475
37Proximal tubulopathy (HP:0000114)2.92011109
38Increased purine levels (HP:0004368)2.90990474
39Hyperuricemia (HP:0002149)2.90990474
40Flat acetabular roof (HP:0003180)2.88221625
41Increased mean platelet volume (HP:0011877)2.88097685
42Abnormality of small intestinal villus morphology (HP:0011472)2.85547606
43Villous atrophy (HP:0011473)2.85547606
44Pustule (HP:0200039)2.79403606
45Metabolic alkalosis (HP:0200114)2.76651300
46Eczematoid dermatitis (HP:0000976)2.75886884
47Milia (HP:0001056)2.70668105
48Hypercholesterolemia (HP:0003124)2.70169587
49Reticulocytosis (HP:0001923)2.69167951
50Posterior subcapsular cataract (HP:0007787)2.65692789
51Decreased circulating renin level (HP:0003351)2.62979602
52Widely patent fontanelles and sutures (HP:0004492)2.60501188
53Abnormality of glycine metabolism (HP:0010895)2.60310358
54Abnormality of serine family amino acid metabolism (HP:0010894)2.60310358
55Alkalosis (HP:0001948)2.59733807
56Abnormal urine phosphate concentration (HP:0012599)2.59125368
57Syncope (HP:0001279)2.58653615
58Megaloblastic anemia (HP:0001889)2.58643212
59Hyperparathyroidism (HP:0000843)2.55986584
60Abnormal platelet volume (HP:0011876)2.52315436
61Abnormality of the gastric mucosa (HP:0004295)2.51780411
62Progressive hearing impairment (HP:0001730)2.50433856
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.49886222
64Tongue fasciculations (HP:0001308)2.48276636
65Autoimmune hemolytic anemia (HP:0001890)2.46810160
66Palpitations (HP:0001962)2.45001524
67Facial diplegia (HP:0001349)2.44981425
68Enlarged epiphyses (HP:0010580)2.44873078
69Hyperammonemia (HP:0001987)2.43486871
70Woolly hair (HP:0002224)2.40529805
71Hyperphosphaturia (HP:0003109)2.37996145
72Hemorrhage of the eye (HP:0011885)2.35116588
73Abnormal biliary tract morphology (HP:0012440)2.34558361
74Cerebral palsy (HP:0100021)2.34306915
75Alopecia of scalp (HP:0002293)2.32931949
76Xanthomatosis (HP:0000991)2.32173805
77Dicarboxylic aciduria (HP:0003215)2.31750283
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31750283
79Petechiae (HP:0000967)2.30068257
80Steatorrhea (HP:0002570)2.28976667
81Micronodular cirrhosis (HP:0001413)2.28677835
82Delayed epiphyseal ossification (HP:0002663)2.27641784
83Elevated erythrocyte sedimentation rate (HP:0003565)2.27118711
84Hyperactive renin-angiotensin system (HP:0000841)2.25007289
85Dehydration (HP:0001944)2.23916924
86Epidermoid cyst (HP:0200040)2.23069414
87Metabolic acidosis (HP:0001942)2.22991874
88Muscle fibrillation (HP:0010546)2.22572642
89Agammaglobulinemia (HP:0004432)2.21346323
90Abnormality of purine metabolism (HP:0004352)2.19692411
91Abnormality of the costochondral junction (HP:0000919)2.17824824
92Hypotension (HP:0002615)2.17645279
93Pili torti (HP:0003777)2.16425140
94Pancreatitis (HP:0001733)2.14633783
95Hand muscle atrophy (HP:0009130)2.11925807
96Skin rash (HP:0000988)2.10986204
97Rectal prolapse (HP:0002035)2.08241740
98Encephalitis (HP:0002383)2.05896898
99Abnormality of renin-angiotensin system (HP:0000847)2.02651015
100Fragile nails (HP:0001808)2.01927060
101Congenital sensorineural hearing impairment (HP:0008527)2.01247535
102Abnormality of the 1st metacarpal (HP:0010009)1.97413548
103Gout (HP:0001997)1.97021160
104Late onset (HP:0003584)1.96175782
105Mesangial abnormality (HP:0001966)1.95160759
106Fragile skin (HP:0001030)1.94563527
107Abnormal enzyme/coenzyme activity (HP:0012379)1.93937114
108Biliary tract neoplasm (HP:0100574)1.93236992
109Paresthesia (HP:0003401)1.92854706
110Protuberant abdomen (HP:0001538)1.92244108
111Focal segmental glomerulosclerosis (HP:0000097)1.91884157
112Gingivitis (HP:0000230)1.91861800
113Abnormality of T cell physiology (HP:0011840)1.91361005
114Vasculitis (HP:0002633)1.90832489
115Atrophic scars (HP:0001075)1.90810396
116Abnormal albumin level (HP:0012116)1.90525430
117Hypoalbuminemia (HP:0003073)1.90525430
118Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.89591925
119Polycythemia (HP:0001901)1.88820386
120Facial shape deformation (HP:0011334)1.88185269
121Potter facies (HP:0002009)1.88185269
122Growth hormone excess (HP:0000845)1.88041019
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.87973356
124Stridor (HP:0010307)1.86950654
125Bundle branch block (HP:0011710)1.86333240
126Renal tubular acidosis (HP:0001947)1.85931802
127Subcapsular cataract (HP:0000523)1.85421565
128Hoarse voice (HP:0001609)1.84505950
129Abnormal glucose tolerance (HP:0001952)1.84256603
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.84137981
131Hyperphosphatemia (HP:0002905)1.82596698
132Ventricular tachycardia (HP:0004756)1.81887705
133Amyloidosis (HP:0011034)1.81467123
134Abnormality of B cell number (HP:0010975)1.81201231
135Curly hair (HP:0002212)1.80891001
136Ventricular fibrillation (HP:0001663)1.80763891
137Abnormality of alkaline phosphatase activity (HP:0004379)1.80668133
138Abnormality of urine glucose concentration (HP:0011016)1.80095473
139Glycosuria (HP:0003076)1.80095473
140Gastrointestinal stroma tumor (HP:0100723)1.78777528
141Abnormality of nucleobase metabolism (HP:0010932)1.77428008
142Thin bony cortex (HP:0002753)1.77410083
143Lethargy (HP:0001254)1.77036628
144Increased IgE level (HP:0003212)1.75690202
145Diaphragmatic weakness (HP:0009113)1.75508560
146Complement deficiency (HP:0004431)1.74845908
147Polygenic inheritance (HP:0010982)1.73909776
148Abnormality of complement system (HP:0005339)1.73794446
149Distal upper limb amyotrophy (HP:0007149)1.72690217
150Upper limb amyotrophy (HP:0009129)1.72690217
151Macrocytic anemia (HP:0001972)1.71861805
152Chronic obstructive pulmonary disease (HP:0006510)1.71157149
153Obstructive lung disease (HP:0006536)1.71157149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.61532903
2MST45.97199306
3FRK5.77451974
4MST1R3.94911618
5NME13.69268821
6LMTK23.64907674
7GRK63.62146491
8AKT33.50643968
9RIPK12.98306452
10PRKG22.85011762
11EPHA22.65341605
12MAP2K22.64030253
13PTK62.61085931
14MAP3K102.45023445
15ERN12.08361609
16MAP3K21.99889547
17KDR1.85089891
18EPHB21.76305222
19STK101.64382301
20TESK11.56328783
21MET1.50857448
22TAOK11.46470358
23KIT1.42933324
24TESK21.40630353
25KSR21.32850323
26EPHB11.26996976
27CDK191.21821641
28PRKCI1.19897668
29PAK41.19702160
30PTK21.19293847
31PIK3CA1.18883200
32BTK1.16378144
33MYLK1.15610758
34CSF1R1.15212575
35PRPF4B1.13616884
36FES1.13198001
37DDR21.10800712
38FER1.06500332
39RIPK41.05584023
40MATK1.05465262
41MAP3K81.03561671
42OXSR11.02194250
43TTK1.01381323
44IKBKE1.01068730
45TEC1.00837989
46ERBB21.00659274
47TXK0.99921032
48SYK0.98584902
49MAP3K70.97166726
50MAP3K110.96401187
51BMX0.95777451
52MAP2K10.94519426
53BMPR20.91786624
54ZAP700.90869336
55SCYL20.88252450
56EPHA30.87656721
57NUAK10.85272994
58PIM10.84228285
59TNK20.82989333
60BCKDK0.82590723
61JAK30.80914981
62STK390.79617671
63DMPK0.79551983
64LCK0.79378672
65MAP2K60.78888967
66CDC42BPA0.78848316
67LRRK20.78538572
68NLK0.78019926
69LYN0.77814173
70PIK3CG0.75020296
71FGFR30.74650917
72LATS10.72816087
73MAPK110.72379158
74MAP3K10.71045064
75MAP3K90.70582548
76ICK0.70377878
77EPHA40.66367977
78PRKAA20.65382167
79IRAK40.63158192
80PAK30.63078035
81JAK10.61814896
82TAOK30.61737120
83MAP2K30.58994893
84MAP3K140.52240106
85TNIK0.50109872
86LIMK10.49493156
87ABL20.49166156
88HCK0.48646657
89RET0.46941935
90GRK10.45596671
91MAP3K120.45224817
92CAMK2D0.44809303
93MAP4K10.44470503
94STK30.44396200
95PDPK10.42212015
96IKBKB0.41593620
97TBK10.41359219
98CDK120.41263771
99CDK60.40808668
100AURKB0.40671201
101MAP3K50.40345808
102IRAK10.39633199
103PKN20.38428826
104SRC0.38034227
105EEF2K0.37979318
106BLK0.37330927
107PRKAA10.36756950
108MAPK70.36736297
109PAK10.35095775
110DAPK20.35027518
111PRKCZ0.33583685
112PRKCD0.31859787
113PDK10.31416733
114CSK0.29863187
115PDGFRA0.29587696
116DYRK1B0.28413808
117TYK20.28264285
118PAK20.28176590
119FGR0.27104903
120CAMK2B0.26784610
121ITK0.26060831
122PDK20.25732381
123PRKCA0.25716481
124MAP3K30.25659576
125FYN0.23939407
126ROCK10.23291121
127MAPKAPK20.22500623
128PRKACG0.22043487
129CAMK2G0.21884751
130AKT20.19121110
131MAP3K60.18990539
132PBK0.18667761
133TYRO30.18330853
134FGFR40.17779174
135CSNK1A10.17456119
136CDK50.17058460
137STK110.16924947
138PIM20.15291169
139PRKCQ0.15032125
140TRIB30.14207061
141JAK20.12969168
142ROCK20.12718397
143ALK0.11752658
144GSK3A0.11642828

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.90243672
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.44080689
3Renin-angiotensin system_Homo sapiens_hsa046145.28249454
4Mineral absorption_Homo sapiens_hsa049783.87153055
5Vitamin digestion and absorption_Homo sapiens_hsa049773.60303330
6Bile secretion_Homo sapiens_hsa049762.95664109
7Protein digestion and absorption_Homo sapiens_hsa049742.89356016
8Histidine metabolism_Homo sapiens_hsa003402.41167188
9Galactose metabolism_Homo sapiens_hsa000522.36688920
10Caffeine metabolism_Homo sapiens_hsa002322.30442547
11Sulfur metabolism_Homo sapiens_hsa009202.27641627
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14060324
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07008399
14Fructose and mannose metabolism_Homo sapiens_hsa000511.90230596
15Starch and sucrose metabolism_Homo sapiens_hsa005001.85304690
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.82439897
17Chemical carcinogenesis_Homo sapiens_hsa052041.80280286
18PPAR signaling pathway_Homo sapiens_hsa033201.71105293
19Retinol metabolism_Homo sapiens_hsa008301.67616215
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65184824
21Asthma_Homo sapiens_hsa053101.64542957
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61486129
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58378253
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52962768
25Glycerolipid metabolism_Homo sapiens_hsa005611.49733036
26Allograft rejection_Homo sapiens_hsa053301.46406450
27Tryptophan metabolism_Homo sapiens_hsa003801.40317024
28Graft-versus-host disease_Homo sapiens_hsa053321.37613228
29Thyroid hormone synthesis_Homo sapiens_hsa049181.34829531
30Autoimmune thyroid disease_Homo sapiens_hsa053201.34069120
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.33243242
32Glutathione metabolism_Homo sapiens_hsa004801.27975118
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.26339161
34Arginine and proline metabolism_Homo sapiens_hsa003301.19833484
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15209013
36Folate biosynthesis_Homo sapiens_hsa007901.14735491
37Arginine biosynthesis_Homo sapiens_hsa002201.12346612
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07992384
39Type I diabetes mellitus_Homo sapiens_hsa049401.04513200
40Staphylococcus aureus infection_Homo sapiens_hsa051501.01076558
41Phenylalanine metabolism_Homo sapiens_hsa003600.97536101
42Fatty acid degradation_Homo sapiens_hsa000710.95229320
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92613908
44Tight junction_Homo sapiens_hsa045300.90004818
45Sphingolipid metabolism_Homo sapiens_hsa006000.89579375
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81519536
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79381428
48Antigen processing and presentation_Homo sapiens_hsa046120.79107142
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77932953
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.77045867
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76233453
52ABC transporters_Homo sapiens_hsa020100.75040997
53Other glycan degradation_Homo sapiens_hsa005110.71810743
54Nitrogen metabolism_Homo sapiens_hsa009100.69193902
55beta-Alanine metabolism_Homo sapiens_hsa004100.68909281
56Leishmaniasis_Homo sapiens_hsa051400.68654731
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67937884
58Pyruvate metabolism_Homo sapiens_hsa006200.65081530
59Peroxisome_Homo sapiens_hsa041460.62217435
60Primary immunodeficiency_Homo sapiens_hsa053400.60471283
61Salmonella infection_Homo sapiens_hsa051320.56997531
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56788372
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.55491833
64Linoleic acid metabolism_Homo sapiens_hsa005910.55423731
65Type II diabetes mellitus_Homo sapiens_hsa049300.54929115
66Pancreatic secretion_Homo sapiens_hsa049720.53199149
67Adherens junction_Homo sapiens_hsa045200.52741629
68Carbon metabolism_Homo sapiens_hsa012000.51578044
69Gastric acid secretion_Homo sapiens_hsa049710.51051550
70Pentose phosphate pathway_Homo sapiens_hsa000300.49632607
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43529859
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42666875
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42397465
74GnRH signaling pathway_Homo sapiens_hsa049120.42001806
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.41953275
76Tyrosine metabolism_Homo sapiens_hsa003500.41613366
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40642364
78Sulfur relay system_Homo sapiens_hsa041220.38735896
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38594110
80African trypanosomiasis_Homo sapiens_hsa051430.38552349
81Hepatitis C_Homo sapiens_hsa051600.36226631
82Viral myocarditis_Homo sapiens_hsa054160.36099327
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34966643
84Thyroid cancer_Homo sapiens_hsa052160.34823585
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34637199
86Arachidonic acid metabolism_Homo sapiens_hsa005900.32639760
87Bladder cancer_Homo sapiens_hsa052190.32201915
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29572546
89Lysine degradation_Homo sapiens_hsa003100.29040978
90Ether lipid metabolism_Homo sapiens_hsa005650.28341130
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27644804
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26808931
93Inositol phosphate metabolism_Homo sapiens_hsa005620.26120086
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25161601
95Fatty acid biosynthesis_Homo sapiens_hsa000610.23589200
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.23222270
97Steroid biosynthesis_Homo sapiens_hsa001000.22430897
98Choline metabolism in cancer_Homo sapiens_hsa052310.21062447
99Insulin secretion_Homo sapiens_hsa049110.20677135
100Hematopoietic cell lineage_Homo sapiens_hsa046400.20342787
101VEGF signaling pathway_Homo sapiens_hsa043700.20232114
102Long-term depression_Homo sapiens_hsa047300.20002953
103Salivary secretion_Homo sapiens_hsa049700.19014724
104Renin secretion_Homo sapiens_hsa049240.17786230
105Tuberculosis_Homo sapiens_hsa051520.17675356
106Gap junction_Homo sapiens_hsa045400.17367555
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.16965131
108Vibrio cholerae infection_Homo sapiens_hsa051100.16809272
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16591166
110Biosynthesis of amino acids_Homo sapiens_hsa012300.16490774
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.16183051
112Influenza A_Homo sapiens_hsa051640.15507379
113Glucagon signaling pathway_Homo sapiens_hsa049220.15412035
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15387596
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.14422406
116Butanoate metabolism_Homo sapiens_hsa006500.13987338
117Fatty acid metabolism_Homo sapiens_hsa012120.13373630
118Cocaine addiction_Homo sapiens_hsa050300.13282222
119Insulin resistance_Homo sapiens_hsa049310.12667556
120Amoebiasis_Homo sapiens_hsa051460.11919957
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.10921462
122Metabolic pathways_Homo sapiens_hsa011000.10293530
123N-Glycan biosynthesis_Homo sapiens_hsa005100.09555893
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09504556
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.08853016
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08689681
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08463737
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08370093
129TNF signaling pathway_Homo sapiens_hsa046680.08204888
130Pertussis_Homo sapiens_hsa051330.07453515
131Shigellosis_Homo sapiens_hsa051310.07110210
132Rheumatoid arthritis_Homo sapiens_hsa053230.07025633
133Herpes simplex infection_Homo sapiens_hsa051680.06687102
134Toxoplasmosis_Homo sapiens_hsa051450.06244549
135Chemokine signaling pathway_Homo sapiens_hsa040620.05886745
136B cell receptor signaling pathway_Homo sapiens_hsa046620.02994484
137Fatty acid elongation_Homo sapiens_hsa000620.01768509

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