NAALADL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.62963315
2L-phenylalanine catabolic process (GO:0006559)5.24419428
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.24419428
4aromatic amino acid family catabolic process (GO:0009074)4.73881503
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59975023
6L-phenylalanine metabolic process (GO:0006558)4.59975023
7piRNA metabolic process (GO:0034587)4.42672741
8fatty acid elongation (GO:0030497)4.37671577
9tryptophan catabolic process (GO:0006569)4.35534603
10indole-containing compound catabolic process (GO:0042436)4.35534603
11indolalkylamine catabolic process (GO:0046218)4.35534603
12tryptophan metabolic process (GO:0006568)4.09073714
13bile acid biosynthetic process (GO:0006699)4.08469406
14kynurenine metabolic process (GO:0070189)3.88614287
15protein carboxylation (GO:0018214)3.82999454
16peptidyl-glutamic acid carboxylation (GO:0017187)3.82999454
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.80706863
18alpha-linolenic acid metabolic process (GO:0036109)3.72959254
19bile acid metabolic process (GO:0008206)3.65917714
20homocysteine metabolic process (GO:0050667)3.65905770
21glyoxylate metabolic process (GO:0046487)3.63326010
22regulation of fibrinolysis (GO:0051917)3.62677917
23high-density lipoprotein particle remodeling (GO:0034375)3.62328135
24cysteine metabolic process (GO:0006534)3.61733277
25sulfation (GO:0051923)3.61430400
26urea cycle (GO:0000050)3.57927220
27urea metabolic process (GO:0019627)3.57927220
28DNA methylation involved in gamete generation (GO:0043046)3.53329256
29complement activation, alternative pathway (GO:0006957)3.51563568
30regulation of protein activation cascade (GO:2000257)3.48737963
31amine catabolic process (GO:0009310)3.46069965
32cellular biogenic amine catabolic process (GO:0042402)3.46069965
33serotonin metabolic process (GO:0042428)3.45606074
34coenzyme catabolic process (GO:0009109)3.44962159
35positive regulation of meiosis (GO:0045836)3.39506796
36tyrosine metabolic process (GO:0006570)3.38512446
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37524710
38indole-containing compound metabolic process (GO:0042430)3.37152172
39regulation of hippo signaling (GO:0035330)3.36858397
40sulfur amino acid catabolic process (GO:0000098)3.36091712
41negative regulation of lipase activity (GO:0060192)3.35793868
42negative regulation of fibrinolysis (GO:0051918)3.34070034
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33976373
44cellular glucuronidation (GO:0052695)3.32311825
45neuronal action potential (GO:0019228)3.28985739
46very long-chain fatty acid metabolic process (GO:0000038)3.28853204
47regulation of complement activation (GO:0030449)3.27495108
48regulation of action potential (GO:0098900)3.25740170
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23602292
50aromatic amino acid family metabolic process (GO:0009072)3.23319644
51positive regulation of meiotic cell cycle (GO:0051446)3.23014100
52primary amino compound metabolic process (GO:1901160)3.21741749
53regulation of posttranscriptional gene silencing (GO:0060147)3.16923519
54regulation of gene silencing by miRNA (GO:0060964)3.16923519
55regulation of gene silencing by RNA (GO:0060966)3.16923519
56response to phenylpropanoid (GO:0080184)3.13452157
57protein-lipid complex remodeling (GO:0034368)3.13359849
58macromolecular complex remodeling (GO:0034367)3.13359849
59plasma lipoprotein particle remodeling (GO:0034369)3.13359849
60cholesterol efflux (GO:0033344)3.12997376
61reverse cholesterol transport (GO:0043691)3.12966133
62fibrinolysis (GO:0042730)3.12033524
63nitrogen cycle metabolic process (GO:0071941)3.11727321
64epithelial cilium movement (GO:0003351)3.11717423
65negative regulation of systemic arterial blood pressure (GO:0003085)3.09412255
66linoleic acid metabolic process (GO:0043651)3.09072363
67epoxygenase P450 pathway (GO:0019373)3.07542263
68negative regulation of mast cell activation (GO:0033004)3.06521520
69pharyngeal system development (GO:0060037)3.05720897
70positive regulation of action potential (GO:0045760)3.05653482
71indolalkylamine metabolic process (GO:0006586)3.05049389
72male meiosis I (GO:0007141)3.04881269
73uronic acid metabolic process (GO:0006063)3.04512194
74glucuronate metabolic process (GO:0019585)3.04512194
75regulation of phospholipase A2 activity (GO:0032429)3.02153746
76cilium or flagellum-dependent cell motility (GO:0001539)3.01627510
77regulation of triglyceride catabolic process (GO:0010896)3.01340596
78L-fucose catabolic process (GO:0042355)3.00970420
79fucose catabolic process (GO:0019317)3.00970420
80L-fucose metabolic process (GO:0042354)3.00970420
81regulation of cholesterol esterification (GO:0010872)2.99900591
82regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.99139008
83multicellular organism reproduction (GO:0032504)2.98572096
84fatty-acyl-CoA biosynthetic process (GO:0046949)2.97557458
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.96007596
86positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94619091
87protein polyglutamylation (GO:0018095)2.94314482
88interkinetic nuclear migration (GO:0022027)2.94143615
89drug catabolic process (GO:0042737)2.92678946
90opsonization (GO:0008228)2.92405963
91cofactor catabolic process (GO:0051187)2.91544860
92male meiosis (GO:0007140)2.91471139
93alpha-amino acid catabolic process (GO:1901606)2.89669439
94regulation of bile acid biosynthetic process (GO:0070857)2.89216738
95cellular modified amino acid catabolic process (GO:0042219)2.89128004
96water-soluble vitamin biosynthetic process (GO:0042364)2.88778927
97short-chain fatty acid metabolic process (GO:0046459)2.88547142
98regulation of acrosome reaction (GO:0060046)2.88513917
99parturition (GO:0007567)2.87982039
100ovulation cycle (GO:0042698)2.87632693
101negative regulation of protein localization to cell surface (GO:2000009)2.86297269
102bile acid and bile salt transport (GO:0015721)2.86119891
103gamma-aminobutyric acid transport (GO:0015812)2.85888773
104fatty-acyl-CoA metabolic process (GO:0035337)2.85882861
105regulation of mesoderm development (GO:2000380)2.85605341
106negative regulation of protein activation cascade (GO:2000258)2.85444961
107cilium movement (GO:0003341)2.83927848
108amino-acid betaine metabolic process (GO:0006577)2.83543385
109triglyceride homeostasis (GO:0070328)2.80807862
110acylglycerol homeostasis (GO:0055090)2.80807862
111axoneme assembly (GO:0035082)2.80005313
112phosphatidylinositol acyl-chain remodeling (GO:0036149)2.79601802
113drug transmembrane transport (GO:0006855)2.78996156
114prostate gland growth (GO:0060736)2.78900646
115reflex (GO:0060004)2.78135745
116low-density lipoprotein particle remodeling (GO:0034374)2.78118104
117synapsis (GO:0007129)2.77940323
118serine family amino acid catabolic process (GO:0009071)2.77379692
119phospholipid efflux (GO:0033700)2.77262207
120ethanol oxidation (GO:0006069)2.75974447
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75839907
122omega-hydroxylase P450 pathway (GO:0097267)2.75655041
123cellular amino acid catabolic process (GO:0009063)2.74226649
124arginine metabolic process (GO:0006525)2.74020370
125glutamate metabolic process (GO:0006536)2.73901009
126plasma lipoprotein particle clearance (GO:0034381)2.73730041
127negative regulation of keratinocyte proliferation (GO:0010839)2.73445887
128artery development (GO:0060840)2.72425006
129negative regulation of cholesterol transport (GO:0032375)2.71674436
130negative regulation of sterol transport (GO:0032372)2.71674436
131kidney morphogenesis (GO:0060993)2.70357546
132long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.69875057
133benzene-containing compound metabolic process (GO:0042537)2.69815655
134detection of light stimulus involved in visual perception (GO:0050908)2.68418656
135detection of light stimulus involved in sensory perception (GO:0050962)2.68418656
136aldehyde catabolic process (GO:0046185)2.67750023
137photoreceptor cell maintenance (GO:0045494)2.65727210
138acetyl-CoA metabolic process (GO:0006084)2.65075571
139somite development (GO:0061053)2.64965082
140negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64434392
141cornea development in camera-type eye (GO:0061303)2.63849349
142positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.63761928
143behavioral response to ethanol (GO:0048149)2.62964216
144axon ensheathment in central nervous system (GO:0032291)2.62604117
145central nervous system myelination (GO:0022010)2.62604117
146cellular ketone body metabolic process (GO:0046950)2.62039661
1473-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60835989
148purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60835989
149response to methylmercury (GO:0051597)2.60759927
150acyl-CoA biosynthetic process (GO:0071616)2.59708366
151thioester biosynthetic process (GO:0035384)2.59708366
152action potential (GO:0001508)2.59634343
153retinal metabolic process (GO:0042574)2.57481562
154exogenous drug catabolic process (GO:0042738)2.57380621
155response to pheromone (GO:0019236)2.55957652
156pyrimidine-containing compound transmembrane transport (GO:0072531)2.55343054
157acyl-CoA metabolic process (GO:0006637)2.55302602
158thioester metabolic process (GO:0035383)2.55302602
159cell proliferation in forebrain (GO:0021846)2.55279737
160glycerophospholipid catabolic process (GO:0046475)2.55214418
161otic vesicle formation (GO:0030916)2.48681220
162oxidative demethylation (GO:0070989)2.48050265
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47426911
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.47426911
165NADH dehydrogenase complex assembly (GO:0010257)2.47426911
166regulation of meiosis I (GO:0060631)2.46197703
167magnesium ion transport (GO:0015693)2.42464678
168cellular response to ATP (GO:0071318)2.41945944
169neural tube formation (GO:0001841)2.41728618
170retinal cone cell development (GO:0046549)2.41214920
171signal transduction involved in regulation of gene expression (GO:0023019)2.40367134
172embryonic epithelial tube formation (GO:0001838)2.39967435
173positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.39487434
174regulation of glomerulus development (GO:0090192)2.38520461
175negative regulation of sodium ion transport (GO:0010766)2.38373012
176phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.37359847
177lymphangiogenesis (GO:0001946)2.37275477
178negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34560050
179positive regulation of fatty acid transport (GO:2000193)2.34492863
180DNA deamination (GO:0045006)2.33318941
181chromosome organization involved in meiosis (GO:0070192)2.33174359
182adaptation of signaling pathway (GO:0023058)2.32831817
183spinal cord motor neuron differentiation (GO:0021522)2.32315952
184dopamine transport (GO:0015872)2.32123814
185preassembly of GPI anchor in ER membrane (GO:0016254)2.30796133
186phosphatidylserine acyl-chain remodeling (GO:0036150)2.30611087
187photoreceptor cell development (GO:0042461)2.30515759
188ketone body metabolic process (GO:1902224)2.29667416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.06544472
2EZH2_22144423_ChIP-Seq_EOC_Human3.64749602
3ZNF274_21170338_ChIP-Seq_K562_Hela3.16084333
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11044820
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.99132946
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.65815005
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52442858
8IGF1R_20145208_ChIP-Seq_DFB_Human2.50413540
9GBX2_23144817_ChIP-Seq_PC3_Human2.43627837
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27665097
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22043077
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14694887
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09731476
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07513864
15AR_21572438_ChIP-Seq_LNCaP_Human2.06516896
16TAF15_26573619_Chip-Seq_HEK293_Human2.02282321
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01225168
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98273477
19* EWS_26573619_Chip-Seq_HEK293_Human1.91064059
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91007570
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83992448
22* PIAS1_25552417_ChIP-Seq_VCAP_Human1.83160306
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73057381
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.70165329
25* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65910647
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64489290
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63348041
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60757954
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60603937
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60603937
31* STAT3_23295773_ChIP-Seq_U87_Human1.60542945
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60449180
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60396844
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.59584054
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.59209843
36BCAT_22108803_ChIP-Seq_LS180_Human1.57907638
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55694933
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54756560
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49841826
40* TCF4_23295773_ChIP-Seq_U87_Human1.49251754
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48148845
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47891918
43IRF1_19129219_ChIP-ChIP_H3396_Human1.44435438
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40724484
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40718326
46RNF2_27304074_Chip-Seq_NSC_Mouse1.40022300
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.39472742
48CBP_20019798_ChIP-Seq_JUKART_Human1.37239051
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37239051
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36530251
51VDR_22108803_ChIP-Seq_LS180_Human1.35120413
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34091548
53* AHR_22903824_ChIP-Seq_MCF-7_Human1.33732980
54* P300_19829295_ChIP-Seq_ESCs_Human1.32783430
55* RUNX2_22187159_ChIP-Seq_PCA_Human1.32616767
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32410346
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29498458
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.29409254
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.29396742
60* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28723259
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28513565
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28502835
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27885864
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.27509790
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.26696885
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.26493637
67TP53_18474530_ChIP-ChIP_U2OS_Human1.26104387
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.25981203
69TCF4_22108803_ChIP-Seq_LS180_Human1.25712319
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23974798
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23974798
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.23390097
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23344283
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23344283
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23327020
76* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22341844
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22317212
78* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20247785
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.19951569
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.19597505
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19552315
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19239574
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19041825
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18997765
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.18932621
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17388131
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.17327339
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17063595
89* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16535421
90CJUN_26792858_Chip-Seq_BT549_Human1.15910228
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15728319
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14577079
93TP53_22573176_ChIP-Seq_HFKS_Human1.14489308
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14479533
95REST_21632747_ChIP-Seq_MESCs_Mouse1.14119879
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14047849
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14034520
98HTT_18923047_ChIP-ChIP_STHdh_Human1.13974717
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13762270
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13563388
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.13483666
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12807920
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.12579396
104* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12454927
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12144282
106CDX2_22108803_ChIP-Seq_LS180_Human1.12031346
107SOX2_19829295_ChIP-Seq_ESCs_Human1.11850576
108NANOG_19829295_ChIP-Seq_ESCs_Human1.11850576
109ER_23166858_ChIP-Seq_MCF-7_Human1.11820253
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10942143
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.10912438
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10328558
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.10243369
114TP53_16413492_ChIP-PET_HCT116_Human1.09236878
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.09107463
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.08829305
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08829305
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07948944
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07500726
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07274366
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.06865503
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06336552
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06200865
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05491442
125RXR_22108803_ChIP-Seq_LS180_Human1.05406363
126* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04791596
127* FUS_26573619_Chip-Seq_HEK293_Human1.03983895
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03655120
129* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03516241
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.03046072
131SOX2_20726797_ChIP-Seq_SW620_Human1.02814610
132* AR_25329375_ChIP-Seq_VCAP_Human1.02761133
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.02270973
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02129298
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01771402
136P53_22387025_ChIP-Seq_ESCs_Mouse1.01499387
137Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00874075
138TAL1_26923725_Chip-Seq_HPCs_Mouse1.00569164
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.00082479
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.98986343
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.96962123
142TP63_23658742_ChIP-Seq_EP156T_Human0.96508822
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.96402642
144KDM2B_26808549_Chip-Seq_REH_Human0.95968113
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95011322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.50442870
2MP0005360_urolithiasis4.94163750
3MP0005085_abnormal_gallbladder_physiolo4.86251731
4MP0005365_abnormal_bile_salt3.92894162
5MP0003195_calcinosis3.56303936
6MP0008875_abnormal_xenobiotic_pharmacok3.55133837
7MP0003011_delayed_dark_adaptation2.92642650
8MP0003806_abnormal_nucleotide_metabolis2.80666151
9MP0008877_abnormal_DNA_methylation2.79106442
10MP0003252_abnormal_bile_duct2.70445889
11MP0002160_abnormal_reproductive_system2.65246917
12MP0000566_synostosis2.58144147
13MP0005451_abnormal_body_composition2.54193552
14MP0001346_abnormal_lacrimal_gland2.39788440
15MP0002254_reproductive_system_inflammat2.35341952
16MP0005083_abnormal_biliary_tract2.24495557
17MP0002736_abnormal_nociception_after2.22598917
18MP0006292_abnormal_olfactory_placode2.21729883
19MP0001968_abnormal_touch/_nociception2.17577804
20MP0001666_abnormal_nutrient_absorption2.07966200
21MP0005389_reproductive_system_phenotype2.07025321
22MP0004019_abnormal_vitamin_homeostasis2.04338535
23MP0010329_abnormal_lipoprotein_level2.03635911
24MP0000569_abnormal_digit_pigmentation2.02441162
25MP0003646_muscle_fatigue1.97652312
26MP0009384_cardiac_valve_regurgitation1.95976455
27MP0000579_abnormal_nail_morphology1.93929012
28MP0005332_abnormal_amino_acid1.88352487
29MP0004043_abnormal_pH_regulation1.85569342
30MP0003283_abnormal_digestive_organ1.82644356
31MP0001485_abnormal_pinna_reflex1.82494513
32MP0004145_abnormal_muscle_electrophysio1.82311463
33MP0002102_abnormal_ear_morphology1.80824229
34MP0000631_abnormal_neuroendocrine_gland1.78571100
35MP0008872_abnormal_physiological_respon1.71080665
36MP0002735_abnormal_chemical_nociception1.70975604
37MP0010678_abnormal_skin_adnexa1.70087083
38MP0002837_dystrophic_cardiac_calcinosis1.69785527
39MP0005275_abnormal_skin_tensile1.67807122
40MP0005503_abnormal_tendon_morphology1.64739150
41MP0006072_abnormal_retinal_apoptosis1.59061106
42MP0004381_abnormal_hair_follicle1.57486653
43MP0009745_abnormal_behavioral_response1.56846028
44MP0008438_abnormal_cutaneous_collagen1.56732712
45MP0010386_abnormal_urinary_bladder1.55269054
46MP0002272_abnormal_nervous_system1.54640869
47MP0002653_abnormal_ependyma_morphology1.54467419
48MP0001501_abnormal_sleep_pattern1.53097606
49MP0004142_abnormal_muscle_tone1.51009543
50MP0003868_abnormal_feces_composition1.50566689
51MP0000427_abnormal_hair_cycle1.50466271
52MP0001986_abnormal_taste_sensitivity1.50048882
53MP0005248_abnormal_Harderian_gland1.49822608
54MP0004133_heterotaxia1.48746910
55MP0005645_abnormal_hypothalamus_physiol1.48188398
56MP0002098_abnormal_vibrissa_morphology1.46225011
57MP0001919_abnormal_reproductive_system1.46141653
58MP0003136_yellow_coat_color1.45283315
59MP0000383_abnormal_hair_follicle1.44588547
60MP0005647_abnormal_sex_gland1.44470120
61MP0003950_abnormal_plasma_membrane1.42801870
62MP0002060_abnormal_skin_morphology1.40220446
63MP0003718_maternal_effect1.38736567
64MP0005253_abnormal_eye_physiology1.38080363
65MP0002118_abnormal_lipid_homeostasis1.35620717
66MP0002796_impaired_skin_barrier1.35328777
67MP0002876_abnormal_thyroid_physiology1.34151749
68MP0000537_abnormal_urethra_morphology1.32622162
69MP0002138_abnormal_hepatobiliary_system1.32163559
70MP0002938_white_spotting1.28326713
71MP0006276_abnormal_autonomic_nervous1.27525404
72MP0000049_abnormal_middle_ear1.25812863
73MP0000647_abnormal_sebaceous_gland1.25589959
74MP0002234_abnormal_pharynx_morphology1.25100690
75MP0003890_abnormal_embryonic-extraembry1.23960535
76MP0005171_absent_coat_pigmentation1.20810960
77MP0005410_abnormal_fertilization1.19401552
78MP0000377_abnormal_hair_follicle1.18109700
79MP0001881_abnormal_mammary_gland1.17534308
80MP0001664_abnormal_digestion1.17398912
81MP0005408_hypopigmentation1.17180722
82MP0000230_abnormal_systemic_arterial1.16964604
83MP0003705_abnormal_hypodermis_morpholog1.16188906
84MP0002249_abnormal_larynx_morphology1.15083887
85MP0002282_abnormal_trachea_morphology1.14578620
86MP0009046_muscle_twitch1.14336668
87MP0001177_atelectasis1.12976035
88MP0003119_abnormal_digestive_system1.11171262
89MP0009697_abnormal_copulation1.09762946
90MP0005379_endocrine/exocrine_gland_phen1.09325381
91MP0000026_abnormal_inner_ear1.07789846
92MP0010234_abnormal_vibrissa_follicle1.07100516
93MP0002210_abnormal_sex_determination1.05660661
94MP0002557_abnormal_social/conspecific_i1.05605623
95MP0004742_abnormal_vestibular_system1.05533181
96MP0003936_abnormal_reproductive_system1.05044888
97MP0001486_abnormal_startle_reflex1.03524094
98MP0003690_abnormal_glial_cell1.02423718
99MP0000372_irregular_coat_pigmentation1.02174383
100MP0003698_abnormal_male_reproductive1.00779837
101MP0009250_abnormal_appendicular_skeleto1.00285049
102MP0009764_decreased_sensitivity_to0.99878392
103MP0009780_abnormal_chondrocyte_physiolo0.99751768
104MP0008995_early_reproductive_senescence0.99678178
105MP0000516_abnormal_urinary_system0.98874488
106MP0005367_renal/urinary_system_phenotyp0.98874488
107MP0004134_abnormal_chest_morphology0.98818316
108MP0000762_abnormal_tongue_morphology0.98507374
109MP0002064_seizures0.98444814
110MP0002295_abnormal_pulmonary_circulatio0.97662628
111MP0002572_abnormal_emotion/affect_behav0.97389953
112MP0003453_abnormal_keratinocyte_physiol0.96445023
113MP0005174_abnormal_tail_pigmentation0.94748972
114MP0003938_abnormal_ear_development0.94505560
115MP0002733_abnormal_thermal_nociception0.94414347
116MP0000538_abnormal_urinary_bladder0.93568800
117MP0008004_abnormal_stomach_pH0.93563996
118MP0005646_abnormal_pituitary_gland0.93027741
119MP0001970_abnormal_pain_threshold0.92899383
120MP0005195_abnormal_posterior_eye0.92650968
121MP0000920_abnormal_myelination0.92228341
122MP0001929_abnormal_gametogenesis0.92207392
123MP0003186_abnormal_redox_activity0.91868432
124MP0005167_abnormal_blood-brain_barrier0.91175982
125MP0000653_abnormal_sex_gland0.91119237
126MP0002163_abnormal_gland_morphology0.90751356
127MP0000470_abnormal_stomach_morphology0.90095078
128MP0001963_abnormal_hearing_physiology0.89009241
129MP0002184_abnormal_innervation0.88809913
130MP0002734_abnormal_mechanical_nocicepti0.87401334
131MP0002067_abnormal_sensory_capabilities0.87321753
132MP0000609_abnormal_liver_physiology0.87101194
133MP0009053_abnormal_anal_canal0.86262021
134MP0002928_abnormal_bile_duct0.85092284
135MP0001145_abnormal_male_reproductive0.84712915
136MP0010368_abnormal_lymphatic_system0.84567453
137MP0001440_abnormal_grooming_behavior0.84313876
138MP0004885_abnormal_endolymph0.82660857
139MP0005551_abnormal_eye_electrophysiolog0.82656765
140MP0002277_abnormal_respiratory_mucosa0.82490461
141MP0010771_integument_phenotype0.82184413
142MP0001661_extended_life_span0.81993720
143MP0002108_abnormal_muscle_morphology0.80837854
144MP0003638_abnormal_response/metabolism_0.80076408
145MP0003942_abnormal_urinary_system0.79776775
146MP0001873_stomach_inflammation0.79116616
147MP0003787_abnormal_imprinting0.78596417
148MP0001765_abnormal_ion_homeostasis0.78363774
149MP0002752_abnormal_somatic_nervous0.77726876
150MP0000163_abnormal_cartilage_morphology0.77539831
151MP0001216_abnormal_epidermal_layer0.76723868
152MP0004215_abnormal_myocardial_fiber0.75668246
153MP0005220_abnormal_exocrine_pancreas0.75473558
154MP0000467_abnormal_esophagus_morphology0.74695101
155MP0002168_other_aberrant_phenotype0.73941923
156MP0005584_abnormal_enzyme/coenzyme_acti0.73940091
157MP0000613_abnormal_salivary_gland0.73218557
158MP0005501_abnormal_skin_physiology0.72654999
159MP0005319_abnormal_enzyme/_coenzyme0.72273039
160MP0004782_abnormal_surfactant_physiolog0.72265588
161MP0009840_abnormal_foam_cell0.69483301
162MP0001299_abnormal_eye_distance/0.68443514
163MP0005395_other_phenotype0.66471257
164MP0002233_abnormal_nose_morphology0.65809532
165MP0000639_abnormal_adrenal_gland0.63994862
166MP0002009_preneoplasia0.63503331
167MP0004272_abnormal_basement_membrane0.62301551
168MP0001542_abnormal_bone_strength0.62293887
169MP0000627_abnormal_mammary_gland0.62137478
170MP0002115_abnormal_skeleton_extremities0.61742139
171MP0005508_abnormal_skeleton_morphology0.61582684
172MP0001340_abnormal_eyelid_morphology0.58163747
173MP0009643_abnormal_urine_homeostasis0.57642622
174MP0005636_abnormal_mineral_homeostasis0.57373618
175MP0003937_abnormal_limbs/digits/tail_de0.57034478
176MP0001764_abnormal_homeostasis0.55864916
177MP0003941_abnormal_skin_development0.54698206

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.77008457
2Prolonged partial thromboplastin time (HP:0003645)5.32205870
3Deep venous thrombosis (HP:0002625)5.15666475
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.50468048
5Xanthomatosis (HP:0000991)4.41172597
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.39793896
7Pancreatic cysts (HP:0001737)4.25277836
8True hermaphroditism (HP:0010459)4.21094025
9Hyperlipoproteinemia (HP:0010980)4.10847939
10Pancreatic fibrosis (HP:0100732)4.09278534
11Vascular calcification (HP:0004934)3.87137860
12Fat malabsorption (HP:0002630)3.86632897
13Cardiovascular calcification (HP:0011915)3.78106522
14Hypobetalipoproteinemia (HP:0003563)3.74265377
15Congenital stationary night blindness (HP:0007642)3.71510742
16Abnormality of midbrain morphology (HP:0002418)3.66399405
17Molar tooth sign on MRI (HP:0002419)3.66399405
18Joint hemorrhage (HP:0005261)3.62820361
19Complement deficiency (HP:0004431)3.52806705
20Nephronophthisis (HP:0000090)3.50065343
21Epidermoid cyst (HP:0200040)3.49763756
22Hypophosphatemic rickets (HP:0004912)3.34191499
23Genetic anticipation (HP:0003743)3.17183204
24Abnormality of the renal cortex (HP:0011035)3.13605278
25Steatorrhea (HP:0002570)3.13475383
26Keratoconus (HP:0000563)3.10689647
27Increased corneal curvature (HP:0100692)3.10689647
28Conjugated hyperbilirubinemia (HP:0002908)3.10345956
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09810764
30Abnormality of the renal medulla (HP:0100957)3.09633016
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.05664359
32Abnormality of methionine metabolism (HP:0010901)3.00199029
33Abnormality of alanine metabolism (HP:0010916)2.98496743
34Hyperalaninemia (HP:0003348)2.98496743
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98496743
36Concave nail (HP:0001598)2.97442902
37Hypolipoproteinemia (HP:0010981)2.96588857
38Abnormality of the common coagulation pathway (HP:0010990)2.94726150
39Hyperventilation (HP:0002883)2.93045626
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82904702
41Congenital, generalized hypertrichosis (HP:0004540)2.81661330
42Hypoalphalipoproteinemia (HP:0003233)2.80666060
43Cystic liver disease (HP:0006706)2.79883426
44Progressive cerebellar ataxia (HP:0002073)2.77023015
45Vitreoretinal degeneration (HP:0000655)2.76361446
46Medial flaring of the eyebrow (HP:0010747)2.76006011
47Hypercholesterolemia (HP:0003124)2.72363031
48Gaze-evoked nystagmus (HP:0000640)2.70071735
49Tubular atrophy (HP:0000092)2.67427365
50Abnormality of serine family amino acid metabolism (HP:0010894)2.66179710
51Abnormality of glycine metabolism (HP:0010895)2.66179710
52Pendular nystagmus (HP:0012043)2.65644296
53Absent/shortened dynein arms (HP:0200106)2.64828519
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.64828519
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.64151862
56Abnormality of the intrinsic pathway (HP:0010989)2.63449059
57Rickets (HP:0002748)2.61812494
58Abolished electroretinogram (ERG) (HP:0000550)2.59005568
59Hyperglycinuria (HP:0003108)2.57710384
60Attenuation of retinal blood vessels (HP:0007843)2.53036055
61Epiphyseal dysplasia (HP:0002656)2.53018456
62Male pseudohermaphroditism (HP:0000037)2.52037194
63Parakeratosis (HP:0001036)2.52027302
64Hyperammonemia (HP:0001987)2.50949881
65Abnormality of the renal collecting system (HP:0004742)2.50665267
66Furrowed tongue (HP:0000221)2.50237341
67Abnormality of the axillary hair (HP:0100134)2.49757858
68Abnormality of secondary sexual hair (HP:0009888)2.49757858
69Hyperglycinemia (HP:0002154)2.47776766
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.44744930
71Hypoplasia of the uterus (HP:0000013)2.42964973
72Abnormality of the nasal septum (HP:0000419)2.42145237
73Decreased circulating renin level (HP:0003351)2.41364411
74Ketosis (HP:0001946)2.40710998
75Chronic hepatic failure (HP:0100626)2.40343899
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.36683173
77Short hallux (HP:0010109)2.36249662
78Clumsiness (HP:0002312)2.35294208
79Right ventricular cardiomyopathy (HP:0011663)2.33239179
80Congenital sensorineural hearing impairment (HP:0008527)2.30464518
81Abnormality of the proximal phalanges of the hand (HP:0009834)2.29955855
82Chorioretinal atrophy (HP:0000533)2.29444092
83Sclerocornea (HP:0000647)2.28208461
84Bifid scrotum (HP:0000048)2.28012748
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27541197
86Abnormality of incisor morphology (HP:0011063)2.26854065
87Type II lissencephaly (HP:0007260)2.24102498
88Myocardial infarction (HP:0001658)2.23937032
89Abnormality of complement system (HP:0005339)2.20804816
90Infantile muscular hypotonia (HP:0008947)2.20222458
91Aplasia involving bones of the upper limbs (HP:0009823)2.19987130
92Aplasia of the phalanges of the hand (HP:0009802)2.19987130
93Aplasia involving bones of the extremities (HP:0009825)2.19987130
94Aplasia/Hypoplasia of the hallux (HP:0008362)2.19619220
95Abnormal ciliary motility (HP:0012262)2.17104201
96Inability to walk (HP:0002540)2.15644894
97Abnormal rod and cone electroretinograms (HP:0008323)2.15017941
98Polydipsia (HP:0001959)2.14714946
99Abnormal drinking behavior (HP:0030082)2.14714946
100Renal cortical cysts (HP:0000803)2.14474724
101Gait imbalance (HP:0002141)2.13639089
102Enlarged kidneys (HP:0000105)2.11745749
103Congenital hepatic fibrosis (HP:0002612)2.11126949
104Large for gestational age (HP:0001520)2.10162173
105Abnormality of serum amino acid levels (HP:0003112)2.07021504
106Congenital primary aphakia (HP:0007707)2.06961092
107Aplasia/hypoplasia of the uterus (HP:0008684)2.06051503
108Hepatocellular carcinoma (HP:0001402)2.05768721
109Widely patent fontanelles and sutures (HP:0004492)2.04897889
110Abnormality of proline metabolism (HP:0010907)2.02981422
111Hydroxyprolinuria (HP:0003080)2.02981422
112Neurofibrillary tangles (HP:0002185)2.02733358
113Morphological abnormality of the middle ear (HP:0008609)2.00350027
114Abnormal respiratory motile cilium morphology (HP:0005938)1.99572768
115Abnormal respiratory epithelium morphology (HP:0012253)1.99572768
116Abnormality of fatty-acid metabolism (HP:0004359)1.99334897
117Small hand (HP:0200055)1.98928659
118Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98696458
119Short 1st metacarpal (HP:0010034)1.98696458
120Amyloidosis (HP:0011034)1.98346129
121Anencephaly (HP:0002323)1.96709990
122Abnormality of purine metabolism (HP:0004352)1.96569126
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95352952
124Spontaneous abortion (HP:0005268)1.94479220
125Azoospermia (HP:0000027)1.94399827
126Genital tract atresia (HP:0001827)1.94008979
127Prolonged neonatal jaundice (HP:0006579)1.93754637
128Abnormality of the phalanges of the 2nd finger (HP:0009541)1.92375939
129Abnormal tarsal ossification (HP:0008369)1.92120351
130Nephrogenic diabetes insipidus (HP:0009806)1.90767030
131Abnormality of the middle phalanges of the toes (HP:0010183)1.89040653
132Hypochromic microcytic anemia (HP:0004840)1.88436291
133Abnormality of nucleobase metabolism (HP:0010932)1.87324989
134Postaxial foot polydactyly (HP:0001830)1.86344952
135Onycholysis (HP:0001806)1.85488536
136Fair hair (HP:0002286)1.85412294
137Acanthocytosis (HP:0001927)1.85143948
138Abnormality of the ischium (HP:0003174)1.83041051
139Broad-based gait (HP:0002136)1.82227116
140Progressive inability to walk (HP:0002505)1.81827537
141Protruding tongue (HP:0010808)1.81813838
142Vaginal atresia (HP:0000148)1.81760164
143Ketoacidosis (HP:0001993)1.80769858
144Mitral stenosis (HP:0001718)1.79927982
145Febrile seizures (HP:0002373)1.79750122
146Fibular aplasia (HP:0002990)1.79480216
147Coronal craniosynostosis (HP:0004440)1.78982096
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78892097
149Confusion (HP:0001289)1.78860505
150Bile duct proliferation (HP:0001408)1.78559668
151Abnormal biliary tract physiology (HP:0012439)1.78559668
152Portal hypertension (HP:0001409)1.77260355
153Abnormal respiratory motile cilium physiology (HP:0012261)1.75475972
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.75304271
155Hypoplasia of the fovea (HP:0007750)1.75304271
156Abnormality of the 1st metacarpal (HP:0010009)1.74219298
157Hypothermia (HP:0002045)1.74120703
158Delayed CNS myelination (HP:0002188)1.72643992
159Bony spicule pigmentary retinopathy (HP:0007737)1.71638809
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71468145
161Menorrhagia (HP:0000132)1.71247195
162Amelogenesis imperfecta (HP:0000705)1.70746044
163Respiratory distress (HP:0002098)1.69912927
164Bilateral microphthalmos (HP:0007633)1.69441149
165Abnormality of pyrimidine metabolism (HP:0004353)1.68836716
166Hypoplastic ischia (HP:0003175)1.67250986
167Stenosis of the external auditory canal (HP:0000402)1.67216020
168Protuberant abdomen (HP:0001538)1.67089592
169Hypoplasia of the iris (HP:0007676)1.67087660
170Gingival bleeding (HP:0000225)1.66898193
171Metabolic alkalosis (HP:0200114)1.66649289
172Decreased central vision (HP:0007663)1.66358536
173Axonal loss (HP:0003447)1.66355320
174Tachypnea (HP:0002789)1.66025208
175Short tibia (HP:0005736)1.65892288
176Turricephaly (HP:0000262)1.65807225
177Postaxial hand polydactyly (HP:0001162)1.65664175
178White forelock (HP:0002211)1.65056936
179Glomerulonephritis (HP:0000099)1.64673647
180Poor coordination (HP:0002370)1.63999361
181Abnormality of macular pigmentation (HP:0008002)1.63622344
182Skin nodule (HP:0200036)1.63512882
183Blue irides (HP:0000635)1.63418048
184Adrenal hypoplasia (HP:0000835)1.62008285
185Patchy hypopigmentation of hair (HP:0011365)1.61971441
186Synostosis involving the elbow (HP:0003938)1.61673190
187Humeroradial synostosis (HP:0003041)1.61673190
188Thick nail (HP:0001805)1.60216978
189Metabolic acidosis (HP:0001942)1.60093733
190Tubulointerstitial nephritis (HP:0001970)1.59903328
191Abnormality of the hepatic vasculature (HP:0006707)1.59401828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.68306021
2CASK3.59746091
3STK393.30753026
4NUAK13.26289234
5ACVR1B2.99312298
6SIK12.95578916
7MST42.76295430
8FRK2.64314312
9EPHB12.61176691
10BCR2.55516862
11ERBB42.43667382
12OXSR12.42314423
13PINK12.38437350
14STK38L2.34271774
15ZAK2.33168262
16PNCK2.22680457
17TLK12.05724364
18PIK3CA2.03553459
19NEK61.95670525
20FGFR21.90026342
21WNK31.87126060
22INSRR1.81526344
23BCKDK1.80645101
24MAPK131.77831407
25EPHB21.75986728
26AKT31.75033503
27BRSK21.66390049
28PBK1.64619662
29FER1.60291164
30MST1R1.60221726
31EPHA31.57492505
32PKN11.52175327
33MAP4K21.49557856
34TAOK31.43309514
35PIK3CG1.42383778
36MAP3K21.35008354
37MET1.20806295
38STK31.20553875
39SGK4941.18096277
40SGK2231.18096277
41MAP3K41.15925756
42TNK21.15534266
43EPHA41.14395597
44ADRBK11.11898834
45DDR21.10596756
46GRK11.10045896
47MAPKAPK31.08854566
48WEE11.07926431
49TNIK1.04754088
50MAP3K141.03181789
51TGFBR11.00865181
52MAP2K70.98803191
53PTK2B0.96225975
54TRPM70.94974185
55WNK40.93559095
56TAF10.90762763
57PRKAA20.90251474
58PRKCG0.83547319
59PRKCE0.82863434
60MAP2K40.82148272
61EPHA20.81198048
62VRK10.80481293
63MAP3K30.74788339
64CSNK1G10.71454181
65PRPF4B0.71226413
66MAPKAPK50.70650808
67ERBB30.70585943
68FGFR40.70287753
69JAK10.70155524
70TIE10.69255484
71CAMK1D0.68625468
72MKNK20.67576733
73TEC0.67378743
74EIF2AK20.67197599
75EIF2AK30.66749505
76SGK20.66417214
77PTK60.66197278
78CSNK1A1L0.66050800
79KIT0.65489795
80PDK20.64821669
81CAMKK20.64575814
82PAK30.63754254
83DYRK20.63653936
84ERBB20.63227969
85PRKCQ0.60359787
86MYLK0.60066910
87GSK3A0.58553082
88MELK0.58293643
89CAMK2G0.56797060
90PLK40.56124808
91CAMK1G0.56055004
92BMPR1B0.55961078
93PRKCI0.55810067
94MARK10.54761773
95MAPK120.53848782
96STK240.53579648
97RPS6KA50.52660971
98MAP2K10.52446473
99ABL20.52140751
100OBSCN0.52008381
101NLK0.51628107
102STK160.51243157
103PHKG20.50772487
104PHKG10.50772487
105CAMK2A0.50541708
106MAP3K70.50130817
107CHUK0.49843733
108SGK30.49744312
109PRKACA0.48895978
110WNK10.47128178
111MAPK110.47117800
112NEK90.46856915
113JAK20.46653802
114RPS6KA60.46424602
115CDK190.45784856
116FLT30.43882690
117PDGFRB0.43456040
118PRKAA10.43224975
119CAMK10.43199760
120ROCK10.43120416
121STK110.42808739
122ERN10.42064630
123ROCK20.41453777
124PRKD20.41294868
125MAP2K60.40638876
126DAPK20.40330450
127ADRBK20.40083201
128CSNK1A10.39689867
129MAP3K130.39001853
130CDK80.38884117
131IGF1R0.38658162
132STK380.38377014
133NTRK30.37759594
134ABL10.37534766
135PRKG10.37445393
136IRAK10.35457114
137MUSK0.35153912
138MAPK150.34991057
139PRKCZ0.34884052
140IKBKB0.34682032
141CAMK2B0.34466715
142PLK10.34336428
143CDK30.34126129
144GRK50.34083985
145PRKCA0.33647279
146PDPK10.32763968
147CSNK1G30.32656230
148CAMK2D0.32019855
149PTK20.29710580
150CSNK1G20.28895319
151PLK20.28667640
152BMPR20.28044235

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.67832028
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.10730250
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.52908113
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52487228
5Fatty acid elongation_Homo sapiens_hsa000622.44161912
6Nitrogen metabolism_Homo sapiens_hsa009102.37357092
7Steroid biosynthesis_Homo sapiens_hsa001002.36688168
8Complement and coagulation cascades_Homo sapiens_hsa046102.35618867
9Arginine biosynthesis_Homo sapiens_hsa002202.27269642
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26516375
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.21139570
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19804989
13Chemical carcinogenesis_Homo sapiens_hsa052042.18742891
14Histidine metabolism_Homo sapiens_hsa003402.18623497
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17640982
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17301948
17Nicotine addiction_Homo sapiens_hsa050332.15362271
18Tryptophan metabolism_Homo sapiens_hsa003802.14444367
19Retinol metabolism_Homo sapiens_hsa008302.12091213
20Propanoate metabolism_Homo sapiens_hsa006402.07024592
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.03510366
22Peroxisome_Homo sapiens_hsa041461.96761715
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95695074
24Fatty acid degradation_Homo sapiens_hsa000711.93953976
25Sulfur metabolism_Homo sapiens_hsa009201.88955360
26beta-Alanine metabolism_Homo sapiens_hsa004101.84162636
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82147442
28Butanoate metabolism_Homo sapiens_hsa006501.76667889
29Fatty acid metabolism_Homo sapiens_hsa012121.75018839
30Caffeine metabolism_Homo sapiens_hsa002321.74480088
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71638693
32Olfactory transduction_Homo sapiens_hsa047401.68860723
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61546066
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61543472
35PPAR signaling pathway_Homo sapiens_hsa033201.54633857
36Phenylalanine metabolism_Homo sapiens_hsa003601.51934770
37Taste transduction_Homo sapiens_hsa047421.48077717
38Basal transcription factors_Homo sapiens_hsa030221.47560333
39Fatty acid biosynthesis_Homo sapiens_hsa000611.37588886
40Tyrosine metabolism_Homo sapiens_hsa003501.35307011
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31611782
42Staphylococcus aureus infection_Homo sapiens_hsa051501.28265879
43Insulin secretion_Homo sapiens_hsa049111.26752686
44Homologous recombination_Homo sapiens_hsa034401.13709837
45Vitamin digestion and absorption_Homo sapiens_hsa049771.12534173
46Morphine addiction_Homo sapiens_hsa050321.12426256
47Serotonergic synapse_Homo sapiens_hsa047261.12148467
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11494945
49Circadian entrainment_Homo sapiens_hsa047131.05992016
50ABC transporters_Homo sapiens_hsa020101.05873875
51Bile secretion_Homo sapiens_hsa049761.05167622
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03334359
53Arginine and proline metabolism_Homo sapiens_hsa003301.03086464
54Starch and sucrose metabolism_Homo sapiens_hsa005001.02854337
55Calcium signaling pathway_Homo sapiens_hsa040201.02060926
56Pyruvate metabolism_Homo sapiens_hsa006200.97348676
57Glutamatergic synapse_Homo sapiens_hsa047240.97273673
58Salivary secretion_Homo sapiens_hsa049700.96345500
59Oxidative phosphorylation_Homo sapiens_hsa001900.93945124
60RNA polymerase_Homo sapiens_hsa030200.91667219
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91337617
62Fanconi anemia pathway_Homo sapiens_hsa034600.89694466
63RNA degradation_Homo sapiens_hsa030180.88623656
64Linoleic acid metabolism_Homo sapiens_hsa005910.87847492
65Ether lipid metabolism_Homo sapiens_hsa005650.86831767
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86163820
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.86034614
68Hedgehog signaling pathway_Homo sapiens_hsa043400.84630905
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.83759588
70Vitamin B6 metabolism_Homo sapiens_hsa007500.83073166
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.82572896
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.81145415
73Glutathione metabolism_Homo sapiens_hsa004800.78784553
74Folate biosynthesis_Homo sapiens_hsa007900.78566551
75Cocaine addiction_Homo sapiens_hsa050300.77634911
76Regulation of autophagy_Homo sapiens_hsa041400.76545164
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75210500
78Protein export_Homo sapiens_hsa030600.72904576
79Selenocompound metabolism_Homo sapiens_hsa004500.72799944
80GABAergic synapse_Homo sapiens_hsa047270.71895292
81ECM-receptor interaction_Homo sapiens_hsa045120.71616312
82Cardiac muscle contraction_Homo sapiens_hsa042600.71600927
83Renin secretion_Homo sapiens_hsa049240.70118429
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68310758
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68170528
86Long-term depression_Homo sapiens_hsa047300.68163778
87Fat digestion and absorption_Homo sapiens_hsa049750.66819151
88Amphetamine addiction_Homo sapiens_hsa050310.65781083
89Cholinergic synapse_Homo sapiens_hsa047250.65584862
90Circadian rhythm_Homo sapiens_hsa047100.65078000
91Gastric acid secretion_Homo sapiens_hsa049710.62296396
92Pancreatic secretion_Homo sapiens_hsa049720.56899086
93Parkinsons disease_Homo sapiens_hsa050120.56578467
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.56288274
95Ovarian steroidogenesis_Homo sapiens_hsa049130.55459477
96Huntingtons disease_Homo sapiens_hsa050160.55325591
97Protein digestion and absorption_Homo sapiens_hsa049740.55174873
98Dopaminergic synapse_Homo sapiens_hsa047280.54617059
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52578206
100One carbon pool by folate_Homo sapiens_hsa006700.52216509
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51747872
102cAMP signaling pathway_Homo sapiens_hsa040240.49348723
103Glycerolipid metabolism_Homo sapiens_hsa005610.48069079
104Sphingolipid metabolism_Homo sapiens_hsa006000.46706151
105Arachidonic acid metabolism_Homo sapiens_hsa005900.46633508
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45673397
107Oxytocin signaling pathway_Homo sapiens_hsa049210.43916644
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43853764
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.43576753
110Alzheimers disease_Homo sapiens_hsa050100.41579222
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41432930
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41064191
113Metabolic pathways_Homo sapiens_hsa011000.40240588
114Melanoma_Homo sapiens_hsa052180.39718101
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37871066
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37426765
117Axon guidance_Homo sapiens_hsa043600.37025718
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36549959
119Collecting duct acid secretion_Homo sapiens_hsa049660.35830460
120TGF-beta signaling pathway_Homo sapiens_hsa043500.34922660
121Purine metabolism_Homo sapiens_hsa002300.34378804
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34190797
123Lysine degradation_Homo sapiens_hsa003100.31582830
124Biosynthesis of amino acids_Homo sapiens_hsa012300.31353551
125Phototransduction_Homo sapiens_hsa047440.31291253
126Rheumatoid arthritis_Homo sapiens_hsa053230.29816273
127Carbon metabolism_Homo sapiens_hsa012000.25535267
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24485686
129Malaria_Homo sapiens_hsa051440.23972537
130Basal cell carcinoma_Homo sapiens_hsa052170.22071913
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17072692
132Dorso-ventral axis formation_Homo sapiens_hsa043200.16060583
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14982350
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14941931
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14479709
136Tight junction_Homo sapiens_hsa045300.12605417
137Prostate cancer_Homo sapiens_hsa052150.11483580
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.10462367
139Phagosome_Homo sapiens_hsa041450.09984945
140Amoebiasis_Homo sapiens_hsa051460.08842171
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.07901916
142Hepatitis C_Homo sapiens_hsa051600.07672073
143Adherens junction_Homo sapiens_hsa045200.06586526
144Focal adhesion_Homo sapiens_hsa045100.06510276
145Mineral absorption_Homo sapiens_hsa049780.06359677
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06140336
147Hippo signaling pathway_Homo sapiens_hsa043900.05451945

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