NAB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)8.49895384
2negative regulation of neurotransmitter transport (GO:0051589)5.63807587
3phospholipid scrambling (GO:0017121)5.48908824
4negative regulation of amino acid transport (GO:0051956)4.88097335
5positive regulation of amino acid transport (GO:0051957)4.64138426
6positive regulation of catecholamine secretion (GO:0033605)4.58121514
7L-phenylalanine catabolic process (GO:0006559)4.32520819
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32520819
9L-phenylalanine metabolic process (GO:0006558)4.00077034
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.00077034
11desmosome organization (GO:0002934)3.97720083
12peptidyl-glutamic acid carboxylation (GO:0017187)3.91218841
13protein carboxylation (GO:0018214)3.91218841
14aromatic amino acid family catabolic process (GO:0009074)3.86803685
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84309109
16intestinal epithelial cell development (GO:0060576)3.77894146
17regulation of transforming growth factor beta2 production (GO:0032909)3.69649876
18mannose metabolic process (GO:0006013)3.65505289
19regulation of glutamate secretion (GO:0014048)3.62762312
20negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.61601148
21alpha-linolenic acid metabolic process (GO:0036109)3.58253282
22pathway-restricted SMAD protein phosphorylation (GO:0060389)3.54687705
23complement activation, alternative pathway (GO:0006957)3.51541682
24negative regulation of fibrinolysis (GO:0051918)3.50097462
25negative regulation of organic acid transport (GO:0032891)3.49618373
26positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.46249093
27indole-containing compound catabolic process (GO:0042436)3.41292728
28indolalkylamine catabolic process (GO:0046218)3.41292728
29tryptophan catabolic process (GO:0006569)3.41292728
30regulation of fibrinolysis (GO:0051917)3.34570139
31bile acid biosynthetic process (GO:0006699)3.33642851
32plasma lipoprotein particle clearance (GO:0034381)3.33489131
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33291363
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33291363
35keratinocyte proliferation (GO:0043616)3.31282751
36regulation of protein activation cascade (GO:2000257)3.30775814
37tryptophan metabolic process (GO:0006568)3.30741485
38fibrinolysis (GO:0042730)3.25431475
39kynurenine metabolic process (GO:0070189)3.25359119
40early endosome to late endosome transport (GO:0045022)3.24426640
41regulation of membrane lipid distribution (GO:0097035)3.24399644
42high-density lipoprotein particle remodeling (GO:0034375)3.23985114
43urea metabolic process (GO:0019627)3.20790265
44urea cycle (GO:0000050)3.20790265
45phospholipid efflux (GO:0033700)3.14990112
46hypotonic response (GO:0006971)3.13870710
47regulation of Rac protein signal transduction (GO:0035020)3.12939594
48regulation of complement activation (GO:0030449)3.12363173
49hemidesmosome assembly (GO:0031581)3.09873251
50cysteine metabolic process (GO:0006534)3.03602024
51nuclear pore complex assembly (GO:0051292)3.03166314
52phospholipid translocation (GO:0045332)3.01055220
53lipid translocation (GO:0034204)3.01055220
54reverse cholesterol transport (GO:0043691)3.00408465
55antigen processing and presentation of endogenous antigen (GO:0019883)2.97360366
56regulation of triglyceride catabolic process (GO:0010896)2.95000271
57cellular glucuronidation (GO:0052695)2.92812296
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92718827
59glyoxylate metabolic process (GO:0046487)2.91351058
60nerve growth factor signaling pathway (GO:0038180)2.90777367
61tyrosine metabolic process (GO:0006570)2.85340967
62growth hormone receptor signaling pathway (GO:0060396)2.84704527
63Rap protein signal transduction (GO:0032486)2.84075285
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84020954
65nitrogen cycle metabolic process (GO:0071941)2.82596695
66cholesterol efflux (GO:0033344)2.81846696
67protein-lipid complex remodeling (GO:0034368)2.81287893
68macromolecular complex remodeling (GO:0034367)2.81287893
69plasma lipoprotein particle remodeling (GO:0034369)2.81287893
70acute-phase response (GO:0006953)2.78684143
71phospholipid homeostasis (GO:0055091)2.77372197
72opsonization (GO:0008228)2.75966676
73bile acid metabolic process (GO:0008206)2.75902192
74bundle of His cell to Purkinje myocyte communication (GO:0086069)2.75880819
75sulfur amino acid catabolic process (GO:0000098)2.75718203
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73345108
77triglyceride homeostasis (GO:0070328)2.72956193
78acylglycerol homeostasis (GO:0055090)2.72956193
79homocysteine metabolic process (GO:0050667)2.72678823
80positive regulation of lipid catabolic process (GO:0050996)2.72039650
81positive regulation of blood coagulation (GO:0030194)2.71974636
82positive regulation of hemostasis (GO:1900048)2.71974636
83negative regulation of cholesterol transport (GO:0032375)2.70183232
84negative regulation of sterol transport (GO:0032372)2.70183232
85plasma lipoprotein particle assembly (GO:0034377)2.68871899
86low-density lipoprotein particle clearance (GO:0034383)2.68513746
87protein-lipid complex assembly (GO:0065005)2.66598313
88negative regulation of amine transport (GO:0051953)2.65974779
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65817456
90negative regulation of protein tyrosine kinase activity (GO:0061099)2.65757377
91smooth muscle tissue development (GO:0048745)2.65587180
92regulation of vitamin D biosynthetic process (GO:0060556)2.64952082
93positive regulation of coagulation (GO:0050820)2.64813802
94cell adhesion mediated by integrin (GO:0033627)2.64446334
95aromatic amino acid family metabolic process (GO:0009072)2.63971787
96peptidyl-threonine modification (GO:0018210)2.63869706
97peptidyl-threonine phosphorylation (GO:0018107)2.59921831
98regulation of cholesterol esterification (GO:0010872)2.59184507
99uronic acid metabolic process (GO:0006063)2.58993252
100glucuronate metabolic process (GO:0019585)2.58993252
101gland morphogenesis (GO:0022612)2.58847398
102nuclear pore organization (GO:0006999)2.58724193
103regulation of cholesterol storage (GO:0010885)2.56310237
104negative regulation of lipid storage (GO:0010888)2.55361078
105actin filament capping (GO:0051693)2.53988696
106regulation of cholesterol homeostasis (GO:2000188)2.53574914
107cellular response to ethanol (GO:0071361)2.52670441
108regulation of membrane protein ectodomain proteolysis (GO:0051043)2.52603634
109gap junction assembly (GO:0016264)2.52409529
110regulation of interleukin-12 biosynthetic process (GO:0045075)2.51846950
111negative regulation of lipase activity (GO:0060192)2.48655248
112lipoprotein metabolic process (GO:0042157)2.48293092
113sterol homeostasis (GO:0055092)2.47819486
114positive regulation of gamma-delta T cell activation (GO:0046645)2.47633669
115cholesterol homeostasis (GO:0042632)2.47538787
116regulation of amino acid transport (GO:0051955)2.47298977
117interleukin-6-mediated signaling pathway (GO:0070102)2.47116371
118neutrophil activation involved in immune response (GO:0002283)2.46525371
119amino-acid betaine metabolic process (GO:0006577)2.46280134
120cellular response to growth hormone stimulus (GO:0071378)2.45027034
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44528370
122positive regulation of fatty acid beta-oxidation (GO:0032000)2.44375553
123negative regulation of gluconeogenesis (GO:0045721)2.43735225
124regulation of heterotypic cell-cell adhesion (GO:0034114)2.43687110
125embryonic process involved in female pregnancy (GO:0060136)2.43439074
126cellular biogenic amine catabolic process (GO:0042402)2.43366413
127amine catabolic process (GO:0009310)2.43366413
128negative regulation of erythrocyte differentiation (GO:0045647)2.43074369
129protein activation cascade (GO:0072376)2.42836790
130mature B cell differentiation (GO:0002335)2.42783879
131positive regulation of interferon-alpha production (GO:0032727)2.42694310
132complement activation (GO:0006956)2.42030009
133regulation of interferon-alpha production (GO:0032647)2.40144540
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40010737
135morphogenesis of an epithelial sheet (GO:0002011)2.39687121
136protein-lipid complex subunit organization (GO:0071825)2.39665720
137plasma lipoprotein particle organization (GO:0071827)2.39062692
138positive regulation of p38MAPK cascade (GO:1900745)2.37717030
139negative regulation of hemostasis (GO:1900047)2.37094639
140negative regulation of blood coagulation (GO:0030195)2.37094639
141regulation of plasminogen activation (GO:0010755)2.37028361
142skin morphogenesis (GO:0043589)2.36940641
143ethanol oxidation (GO:0006069)2.36832864
144positive regulation of triglyceride lipase activity (GO:0061365)2.35911099
145positive regulation of lipoprotein lipase activity (GO:0051006)2.35911099
146bile acid and bile salt transport (GO:0015721)2.34157143
147valine metabolic process (GO:0006573)2.33683639
148platelet-derived growth factor receptor signaling pathway (GO:0048008)2.32859124
149atrial septum morphogenesis (GO:0060413)2.32491049
150positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.31585655
151keratinocyte differentiation (GO:0030216)2.31003806
152epithelial cell fate commitment (GO:0072148)2.30642045
153regulation of protein polyubiquitination (GO:1902914)2.29864801
154mRNA transcription (GO:0009299)2.29084334
155establishment of skin barrier (GO:0061436)2.29032802
156definitive hemopoiesis (GO:0060216)2.28885690
157muscle cell fate commitment (GO:0042693)2.28391889
158regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.27034612
159regulation of transforming growth factor beta production (GO:0071634)2.25770163
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22599594
161interkinetic nuclear migration (GO:0022027)2.21194880
162cytoplasmic mRNA processing body assembly (GO:0033962)2.20941965
163pharyngeal system development (GO:0060037)2.18305068
164negative regulation of anoikis (GO:2000811)2.18207816
165epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14565602
166regulation of transforming growth factor beta1 production (GO:0032908)2.14315653
167negative regulation of cardiac muscle tissue development (GO:0055026)2.13276123
168mature B cell differentiation involved in immune response (GO:0002313)2.13226254
169regulation of fibroblast apoptotic process (GO:2000269)2.12575667
170regulation of smooth muscle cell differentiation (GO:0051150)2.12172549
171histone H3-K9 demethylation (GO:0033169)2.11862627
172negative regulation of activin receptor signaling pathway (GO:0032926)2.11211352
173regulation of vitamin metabolic process (GO:0030656)2.10393029
174regulation of keratinocyte differentiation (GO:0045616)2.08545754
175regulation of neuron projection regeneration (GO:0070570)2.08369836
176regulation of axon regeneration (GO:0048679)2.08369836
177Notch signaling involved in heart development (GO:0061314)2.06739452
178negative regulation of actin filament depolymerization (GO:0030835)2.06729903
179embryonic camera-type eye morphogenesis (GO:0048596)2.06448342
180wound healing, spreading of epidermal cells (GO:0035313)2.05849904
181mitotic sister chromatid cohesion (GO:0007064)2.04631026
182pore complex assembly (GO:0046931)2.04256529
183glycoprotein catabolic process (GO:0006516)2.03424855
184negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.01936353
185cellular response to osmotic stress (GO:0071470)2.01744448
186polyol transport (GO:0015791)2.01264365
187cellular response to thyroid hormone stimulus (GO:0097067)2.00037922
188gastrulation with mouth forming second (GO:0001702)1.99739895
189negative regulation of exocytosis (GO:0045920)1.99018051
190N-glycan processing (GO:0006491)1.98116507
191regulation of water loss via skin (GO:0033561)1.97240385
192negative regulation of smooth muscle cell differentiation (GO:0051151)1.95764388
193protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)1.95570450
194long-term synaptic potentiation (GO:0060291)1.95470519
195negative regulation of heart growth (GO:0061117)1.94039145
196negative regulation of cardiac muscle tissue growth (GO:0055022)1.94039145
197negative regulation of fatty acid transport (GO:2000192)1.93829541
198columnar/cuboidal epithelial cell development (GO:0002066)1.93049089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71970888
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.28716596
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.17204845
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.90469896
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.64144620
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.63743002
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.56725637
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.34849410
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81540080
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62851446
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.55180227
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54250393
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45404232
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.39031427
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.35856744
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35690114
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33397013
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.29635936
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28311569
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20065127
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19536744
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16558501
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14325087
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07877065
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06496251
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.04256554
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.04230369
28* CLOCK_20551151_ChIP-Seq_293T_Human2.01991882
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.89406978
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87574351
31GATA1_22025678_ChIP-Seq_K562_Human1.85656593
32RUNX_20019798_ChIP-Seq_JUKART_Human1.84765894
33* EP300_21415370_ChIP-Seq_HL-1_Mouse1.84507697
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82802568
35IGF1R_20145208_ChIP-Seq_DFB_Human1.82063825
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78673248
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.74996513
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71403908
39* FOXO3_23340844_ChIP-Seq_DLD1_Human1.70504714
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69966739
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.59759875
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.59270356
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57032530
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54587704
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53912649
46TP53_18474530_ChIP-ChIP_U2OS_Human1.51820164
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50903753
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49020958
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48483322
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47281500
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47055010
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46757473
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44910806
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44715222
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44446443
56GBX2_23144817_ChIP-Seq_PC3_Human1.44205090
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43994996
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43866362
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37827902
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.34680931
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34327749
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32249388
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32078735
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31702699
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30995235
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30995235
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.30824087
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29656353
69CJUN_26792858_Chip-Seq_BT549_Human1.28628332
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.28083740
71VDR_24787735_ChIP-Seq_THP-1_Human1.27750564
72SOX2_20726797_ChIP-Seq_SW620_Human1.27671035
73AHR_22903824_ChIP-Seq_MCF-7_Human1.27630487
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26770263
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.25957137
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24438242
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23921879
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23917397
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23917397
80MYB_26560356_Chip-Seq_TH2_Human1.23801037
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23596155
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.21533637
83* BRD4_25478319_ChIP-Seq_HGPS_Human1.21434694
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.21324279
85* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20996025
86SCL_19346495_ChIP-Seq_HPC-7_Human1.20981042
87SMAD4_21799915_ChIP-Seq_A2780_Human1.19214937
88EGR1_19032775_ChIP-ChIP_M12_Human1.17010812
89* PU_27001747_Chip-Seq_BMDM_Mouse1.16957036
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16360696
91FUS_26573619_Chip-Seq_HEK293_Human1.15715366
92MAF_26560356_Chip-Seq_TH1_Human1.14835000
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.13788871
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.13472225
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13132373
96MYB_26560356_Chip-Seq_TH1_Human1.12617270
97* TP53_16413492_ChIP-PET_HCT116_Human1.12561775
98AR_21909140_ChIP-Seq_LNCAP_Human1.11680296
99EWS_26573619_Chip-Seq_HEK293_Human1.11534516
100* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10667748
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08857409
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08182125
103* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06807456
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06648042
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05796684
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05448068
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04862469
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04087989
109GATA4_25053715_ChIP-Seq_YYC3_Human1.03959927
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03687170
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.03570553
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03537193
113P300_19829295_ChIP-Seq_ESCs_Human1.02230995
114* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02107843
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01855658
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01854332
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01149773
118* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01073524
119SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00880205
120TAF15_26573619_Chip-Seq_HEK293_Human1.00431209
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97657902
122WT1_19549856_ChIP-ChIP_CCG9911_Human0.97620353
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97618793
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97189970
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96972316
126* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96633915
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96222741
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95929651
129CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95837174
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94954210
131* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94292504
132GATA2_19941826_ChIP-Seq_K562_Human0.94035250
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93094056
134* EZH2_27294783_Chip-Seq_NPCs_Mouse0.92965722
135* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92444627
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91426063
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91255448
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90315262
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90260147
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.90088647
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89963970
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89555563
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89035947
144VDR_24763502_ChIP-Seq_THP-1_Human0.88677934
145* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88569370
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88541564
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87511238
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86956598
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86302299
150GATA3_27048872_Chip-Seq_THYMUS_Human0.86242574
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86045828
152TCF7_22412390_ChIP-Seq_EML_Mouse0.85472317
153* TP63_23658742_ChIP-Seq_EP156T_Human0.83621708
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.81486909
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81303573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.09020296
2MP0005360_urolithiasis3.84657841
3MP0005085_abnormal_gallbladder_physiolo3.05081653
4MP0005365_abnormal_bile_salt2.95282677
5MP0002009_preneoplasia2.79997774
6MP0008875_abnormal_xenobiotic_pharmacok2.49875310
7MP0002396_abnormal_hematopoietic_system2.48144844
8MP0006054_spinal_hemorrhage2.30836318
9MP0008961_abnormal_basal_metabolism2.27654981
10MP0004808_abnormal_hematopoietic_stem2.26840110
11MP0003252_abnormal_bile_duct2.22627965
12MP0005409_darkened_coat_color2.22213774
13MP0003436_decreased_susceptibility_to2.21972786
14MP0003300_gastrointestinal_ulcer2.20472177
15MP0008004_abnormal_stomach_pH2.17690938
16MP0003724_increased_susceptibility_to2.17494740
17MP0009840_abnormal_foam_cell2.12419913
18MP0003191_abnormal_cellular_cholesterol2.11897675
19MP0003303_peritoneal_inflammation2.10325266
20MP0008057_abnormal_DNA_replication2.06847402
21MP0003828_pulmonary_edema2.05106225
22MP0001835_abnormal_antigen_presentation2.01667130
23MP0003705_abnormal_hypodermis_morpholog1.99070825
24MP0005083_abnormal_biliary_tract1.94982905
25MP0002138_abnormal_hepatobiliary_system1.90773636
26MP0010329_abnormal_lipoprotein_level1.90241646
27MP0000579_abnormal_nail_morphology1.83532860
28MP0009785_altered_susceptibility_to1.82393601
29MP0004947_skin_inflammation1.79142763
30MP0003195_calcinosis1.72603538
31MP0001666_abnormal_nutrient_absorption1.69678659
32MP0008438_abnormal_cutaneous_collagen1.64233677
33MP0000685_abnormal_immune_system1.62149130
34MP0002419_abnormal_innate_immunity1.61873361
35MP0005387_immune_system_phenotype1.61400420
36MP0001790_abnormal_immune_system1.61400420
37MP0002254_reproductive_system_inflammat1.60875748
38MP0004215_abnormal_myocardial_fiber1.60847143
39MP0005000_abnormal_immune_tolerance1.57257338
40MP0001533_abnormal_skeleton_physiology1.54166180
41MP0010234_abnormal_vibrissa_follicle1.52757430
42MP0001800_abnormal_humoral_immune1.52092775
43MP0006082_CNS_inflammation1.51949237
44MP0009764_decreased_sensitivity_to1.51861534
45MP0004084_abnormal_cardiac_muscle1.51562964
46MP0005025_abnormal_response_to1.50837398
47MP0000609_abnormal_liver_physiology1.50681698
48MP0005076_abnormal_cell_differentiation1.49413286
49MP0005451_abnormal_body_composition1.47374738
50MP0005464_abnormal_platelet_physiology1.47305390
51MP0004883_abnormal_blood_vessel1.44525250
52MP0001915_intracranial_hemorrhage1.42816112
53MP0004272_abnormal_basement_membrane1.42475179
54MP0002166_altered_tumor_susceptibility1.41662826
55MP0002452_abnormal_antigen_presenting1.39019149
56MP0002933_joint_inflammation1.38250913
57MP0002148_abnormal_hypersensitivity_rea1.37046146
58MP0003941_abnormal_skin_development1.35970945
59MP0001853_heart_inflammation1.34798387
60MP0000569_abnormal_digit_pigmentation1.34728603
61* MP0003453_abnormal_keratinocyte_physiol1.33344833
62MP0002723_abnormal_immune_serum1.33178738
63MP0005671_abnormal_response_to1.29552347
64MP0010155_abnormal_intestine_physiology1.29041661
65MP0008469_abnormal_protein_level1.28894859
66MP0001845_abnormal_inflammatory_respons1.27612201
67MP0003806_abnormal_nucleotide_metabolis1.27505400
68MP0005275_abnormal_skin_tensile1.25706824
69MP0000767_abnormal_smooth_muscle1.25384809
70MP0002006_tumorigenesis1.24769381
71MP0002060_abnormal_skin_morphology1.23427167
72MP0005332_abnormal_amino_acid1.22587750
73MP0004510_myositis1.22009160
74MP0005503_abnormal_tendon_morphology1.21608326
75MP0001177_atelectasis1.21543345
76MP0002133_abnormal_respiratory_system1.21356908
77MP0005388_respiratory_system_phenotype1.21356908
78MP0002118_abnormal_lipid_homeostasis1.20803439
79MP0003690_abnormal_glial_cell1.19611832
80MP0000762_abnormal_tongue_morphology1.19599470
81MP0009384_cardiac_valve_regurgitation1.18327791
82MP0003566_abnormal_cell_adhesion1.17871322
83MP0010352_gastrointestinal_tract_polyps1.16292873
84MP0000465_gastrointestinal_hemorrhage1.15578080
85MP0010368_abnormal_lymphatic_system1.15474313
86MP0002234_abnormal_pharynx_morphology1.14822684
87MP0009763_increased_sensitivity_to1.13803662
88MP0005023_abnormal_wound_healing1.13646451
89MP0005666_abnormal_adipose_tissue1.13385090
90MP0001819_abnormal_immune_cell1.12812407
91MP0002420_abnormal_adaptive_immunity1.12637559
92MP0004484_altered_response_of1.11757318
93MP0003935_abnormal_craniofacial_develop1.10133340
94MP0001873_stomach_inflammation1.09916997
95MP0005408_hypopigmentation1.09718415
96MP0002896_abnormal_bone_mineralization1.09407936
97MP0004019_abnormal_vitamin_homeostasis1.08272825
98MP0005595_abnormal_vascular_smooth1.07322062
99MP0000432_abnormal_head_morphology1.06640429
100MP0005058_abnormal_lysosome_morphology1.06449814
101MP0002405_respiratory_system_inflammati1.05326463
102MP0003115_abnormal_respiratory_system1.04120229
103MP0002998_abnormal_bone_remodeling1.02970971
104MP0005319_abnormal_enzyme/_coenzyme1.02716047
105MP0000604_amyloidosis1.01789114
106MP0001851_eye_inflammation1.01105238
107MP0000428_abnormal_craniofacial_morphol0.99934538
108MP0010678_abnormal_skin_adnexa0.99111424
109MP0002796_impaired_skin_barrier0.99080037
110MP0002233_abnormal_nose_morphology0.99014678
111MP0003868_abnormal_feces_composition0.98638812
112MP0003448_altered_tumor_morphology0.98157110
113MP0005167_abnormal_blood-brain_barrier0.96546619
114MP0009697_abnormal_copulation0.95510180
115MP0010630_abnormal_cardiac_muscle0.95030616
116MP0005501_abnormal_skin_physiology0.93472592
117MP0000858_altered_metastatic_potential0.93182629
118MP0000383_abnormal_hair_follicle0.92776326
119* MP0001216_abnormal_epidermal_layer0.92204334
120MP0001879_abnormal_lymphatic_vessel0.91962906
121MP0005584_abnormal_enzyme/coenzyme_acti0.91806681
122MP0000598_abnormal_liver_morphology0.90882423
123MP0001243_abnormal_dermal_layer0.90168948
124MP0005166_decreased_susceptibility_to0.88827642
125MP0003763_abnormal_thymus_physiology0.88596741
126MP0002877_abnormal_melanocyte_morpholog0.88543044
127MP0000013_abnormal_adipose_tissue0.88171001
128MP0003075_altered_response_to0.87271861
129MP0003656_abnormal_erythrocyte_physiolo0.86797795
130MP0009643_abnormal_urine_homeostasis0.85786802
131MP0010771_integument_phenotype0.85559637
132MP0004185_abnormal_adipocyte_glucose0.85187461
133MP0003890_abnormal_embryonic-extraembry0.84165096
134MP0000343_altered_response_to0.84137752
135MP0000249_abnormal_blood_vessel0.83872624
136MP0001849_ear_inflammation0.83839348
137MP0003091_abnormal_cell_migration0.83589824
138MP0005164_abnormal_response_to0.82936890
139MP0006138_congestive_heart_failure0.82749442
140MP0003045_fibrosis0.82710863
141MP0003186_abnormal_redox_activity0.82705552
142MP0004264_abnormal_extraembryonic_tissu0.81718132
143MP0001881_abnormal_mammary_gland0.80790999
144MP0000716_abnormal_immune_system0.80359927
145MP0002925_abnormal_cardiovascular_devel0.79701705
146MP0002086_abnormal_extraembryonic_tissu0.79651255
147MP0004782_abnormal_surfactant_physiolog0.78954357
148MP0001784_abnormal_fluid_regulation0.78744285
149* MP0001191_abnormal_skin_condition0.76436313
150MP0003279_aneurysm0.76083697
151MP0003755_abnormal_palate_morphology0.74680410
152MP0010307_abnormal_tumor_latency0.74570010
153MP0004036_abnormal_muscle_relaxation0.73853733
154MP0001188_hyperpigmentation0.71722834
155MP0001614_abnormal_blood_vessel0.69091614
156MP0000566_synostosis0.68951254
157* MP0003634_abnormal_glial_cell0.68726277
158MP0002092_abnormal_eye_morphology0.68598698
159MP0002971_abnormal_brown_adipose0.67585515
160MP0005508_abnormal_skeleton_morphology0.67270144
161MP0000678_abnormal_parathyroid_gland0.66541368
162MP0003183_abnormal_peptide_metabolism0.66197256
163MP0002822_catalepsy0.65913425
164MP0002128_abnormal_blood_circulation0.65623841
165MP0002108_abnormal_muscle_morphology0.65215583

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.04973115
2Xanthomatosis (HP:0000991)4.42184218
3Myocardial infarction (HP:0001658)4.28063965
4Vertebral arch anomaly (HP:0008438)4.18411840
5Intrahepatic cholestasis (HP:0001406)4.16675608
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.97719777
7Hyperlipoproteinemia (HP:0010980)3.85698345
8Abnormality of the common coagulation pathway (HP:0010990)3.82635549
9Prolonged partial thromboplastin time (HP:0003645)3.81399109
10Papillary thyroid carcinoma (HP:0002895)3.59846305
11Joint hemorrhage (HP:0005261)3.56159320
12Recurrent gram-negative bacterial infections (HP:0005420)3.55637260
13Eczematoid dermatitis (HP:0000976)3.54393735
14Complement deficiency (HP:0004431)3.49387923
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47682888
16Arterial tortuosity (HP:0005116)3.27866900
17Epidermoid cyst (HP:0200040)3.09965847
18Hypobetalipoproteinemia (HP:0003563)3.05329352
19Vascular tortuosity (HP:0004948)3.05105693
20Right ventricular cardiomyopathy (HP:0011663)3.03627300
21Hypoalphalipoproteinemia (HP:0003233)2.98015143
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95552478
23Gingival bleeding (HP:0000225)2.93626342
24Peritonitis (HP:0002586)2.88095554
25Recurrent bacterial skin infections (HP:0005406)2.84810173
26Abnormality of complement system (HP:0005339)2.82775374
27Hypolipoproteinemia (HP:0010981)2.81839628
28Ankyloglossia (HP:0010296)2.78879657
29Hematochezia (HP:0002573)2.75615860
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72788705
31Pulmonary embolism (HP:0002204)2.71822545
32Systemic lupus erythematosus (HP:0002725)2.66665329
33Orchitis (HP:0100796)2.66350660
34Fat malabsorption (HP:0002630)2.61891169
35Myositis (HP:0100614)2.60487470
36Atrophic scars (HP:0001075)2.59604787
37Esophageal varix (HP:0002040)2.59111826
38Vascular calcification (HP:0004934)2.59055741
39Osteolytic defects of the hand bones (HP:0009699)2.58725853
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.58725853
41Abnormality of the intrinsic pathway (HP:0010989)2.56243846
42Recurrent abscess formation (HP:0002722)2.55078141
43Cardiovascular calcification (HP:0011915)2.55010114
44Hypercholesterolemia (HP:0003124)2.54362443
45Curly hair (HP:0002212)2.51927926
46Flat acetabular roof (HP:0003180)2.50912862
47Hepatocellular carcinoma (HP:0001402)2.47381930
48Elevated erythrocyte sedimentation rate (HP:0003565)2.44883890
49Abnormal platelet volume (HP:0011876)2.44764387
50Absent frontal sinuses (HP:0002688)2.44562820
51Increased mean platelet volume (HP:0011877)2.41326030
52Arterial thrombosis (HP:0004420)2.40240787
53Mitral stenosis (HP:0001718)2.40181782
54Spontaneous hematomas (HP:0007420)2.39387888
55Abnormality of the renal collecting system (HP:0004742)2.37433393
56Thrombophlebitis (HP:0004418)2.36693062
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.36487429
58Abnormality of macrophages (HP:0004311)2.35884231
59Optic neuritis (HP:0100653)2.35670769
60Retrobulbar optic neuritis (HP:0100654)2.35670769
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33400077
62Nephritis (HP:0000123)2.32587125
63Abnormality of methionine metabolism (HP:0010901)2.32536204
64Lip pit (HP:0100267)2.27565167
65Absent/shortened dynein arms (HP:0200106)2.27406346
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.27406346
67Spinal cord lesions (HP:0100561)2.27393410
68Syringomyelia (HP:0003396)2.27393410
69Amyloidosis (HP:0011034)2.26639874
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.26533697
71Vertebral hypoplasia (HP:0008417)2.26533697
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25131321
73Interstitial pulmonary disease (HP:0006530)2.24230164
74Cubitus valgus (HP:0002967)2.23416725
75Spontaneous abortion (HP:0005268)2.23066186
76Menorrhagia (HP:0000132)2.22073255
77Aplasia cutis congenita (HP:0001057)2.20154448
78Glomerulonephritis (HP:0000099)2.18771684
79Steatorrhea (HP:0002570)2.18425731
80Cerebral aneurysm (HP:0004944)2.17311985
81Thick nail (HP:0001805)2.16671184
82Vasculitis (HP:0002633)2.16216038
83Thickened helices (HP:0000391)2.15733444
84Aplasia involving bones of the upper limbs (HP:0009823)2.13147781
85Aplasia of the phalanges of the hand (HP:0009802)2.13147781
86Aplasia involving bones of the extremities (HP:0009825)2.13147781
87Recurrent skin infections (HP:0001581)2.11148008
88Epistaxis (HP:0000421)2.09310222
89Gastrointestinal infarctions (HP:0005244)2.08248061
90Dilatation of the ascending aorta (HP:0005111)2.08042963
91Subacute progressive viral hepatitis (HP:0006572)2.07424830
92Widely spaced teeth (HP:0000687)2.05069786
93Abnormality of chromosome segregation (HP:0002916)2.04842915
94Abnormality of iron homeostasis (HP:0011031)2.03664070
95Hyperammonemia (HP:0001987)2.03486917
96Abnormality of the lumbar spine (HP:0100712)2.02822611
97Conjugated hyperbilirubinemia (HP:0002908)2.01179583
98Abnormality of the axillary hair (HP:0100134)2.00926802
99Abnormality of secondary sexual hair (HP:0009888)2.00926802
100Abnormal foot bone ossification (HP:0010675)2.00861340
101Menstrual irregularities (HP:0000858)2.00138150
102Abnormality of the distal phalanx of the thumb (HP:0009617)1.99383952
103Thyroid carcinoma (HP:0002890)1.98279869
104Abnormality of oral frenula (HP:0000190)1.97523891
105Selective tooth agenesis (HP:0001592)1.96466126
106Plantar hyperkeratosis (HP:0007556)1.96253468
107Vacuolated lymphocytes (HP:0001922)1.96080999
108Palmar hyperkeratosis (HP:0010765)1.95216203
109Disinhibition (HP:0000734)1.94057629
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93886002
111Transitional cell carcinoma of the bladder (HP:0006740)1.93853353
112Large earlobe (HP:0009748)1.92012132
113Deep philtrum (HP:0002002)1.91665024
114Aortic aneurysm (HP:0004942)1.89687631
115Abnormality of proline metabolism (HP:0010907)1.89652021
116Hydroxyprolinuria (HP:0003080)1.89652021
117Xerostomia (HP:0000217)1.89228601
118Periodontitis (HP:0000704)1.89108382
119Axonal loss (HP:0003447)1.88535779
120Bladder carcinoma (HP:0002862)1.88306600
121Bladder neoplasm (HP:0009725)1.88306600
122Palmoplantar hyperkeratosis (HP:0000972)1.87167544
123Keratoconjunctivitis sicca (HP:0001097)1.86723479
124Abnormality of transition element cation homeostasis (HP:0011030)1.85307736
125Pustule (HP:0200039)1.85088356
126Abnormal tarsal ossification (HP:0008369)1.84868795
127Hypoplastic labia majora (HP:0000059)1.84563525
128Hypoglycemic coma (HP:0001325)1.84056293
129Recurrent fungal infections (HP:0002841)1.84042159
130Hemorrhage of the eye (HP:0011885)1.83965499
131Stomatitis (HP:0010280)1.83171769
132Recurrent viral infections (HP:0004429)1.82306315
133Purpura (HP:0000979)1.81521896
134Mitral valve prolapse (HP:0001634)1.81240987
135Ectopia lentis (HP:0001083)1.81200669
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.81071899
137Increased serum ferritin (HP:0003281)1.80203079
138Gangrene (HP:0100758)1.80152073
139Protuberant abdomen (HP:0001538)1.79480158
140Milia (HP:0001056)1.79264737
141Short middle phalanx of the 5th finger (HP:0004220)1.79197243
142Autoimmune thrombocytopenia (HP:0001973)1.78724818
143Striae distensae (HP:0001065)1.78599288
144Skin nodule (HP:0200036)1.78560110
145Pancreatitis (HP:0001733)1.77866671
146Tetraparesis (HP:0002273)1.76838009
147Colitis (HP:0002583)1.75579542
148Mediastinal lymphadenopathy (HP:0100721)1.73860989
149Pulmonary infiltrates (HP:0002113)1.73549108
150Submucous cleft hard palate (HP:0000176)1.73363325
151Asymmetry of the thorax (HP:0001555)1.73294839
152Hypertriglyceridemia (HP:0002155)1.73291320
153Thoracolumbar scoliosis (HP:0002944)1.73012493
154Inappropriate behavior (HP:0000719)1.71247244
155Onycholysis (HP:0001806)1.71202767
156Urticaria (HP:0001025)1.70837632
157Abnormality of the labia majora (HP:0012881)1.70687166
158Abnormality of nail color (HP:0100643)1.70653711
159Hypotrichosis (HP:0001006)1.70625286
160Aortic dissection (HP:0002647)1.70415244
161Abnormality of incisor morphology (HP:0011063)1.70313203
162Fused cervical vertebrae (HP:0002949)1.69379145
163Long nose (HP:0003189)1.68337785
164Abnormality of the nasolacrimal system (HP:0000614)1.64661320
165Fair hair (HP:0002286)1.63655124
166Sparse scalp hair (HP:0002209)1.63558989
167Mixed hearing impairment (HP:0000410)1.62989385
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62881967
169Cranial hyperostosis (HP:0004437)1.61736233
170Atrioventricular block (HP:0001678)1.60995284
171Lower limb hyperreflexia (HP:0002395)1.60658539
172Abnormality of the salivary glands (HP:0010286)1.60564047
173Cystic hygroma (HP:0000476)1.59949346
174Scanning speech (HP:0002168)1.59053950
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58929609
176Megalencephaly (HP:0001355)1.58904424
177Ridged nail (HP:0001807)1.58710832
178Fragile skin (HP:0001030)1.58646185
179Overgrowth (HP:0001548)1.58090231
180Aneurysm (HP:0002617)1.56994510
181Heterotopia (HP:0002282)1.56173050
182Broad palm (HP:0001169)1.54292678
183Uterine leiomyosarcoma (HP:0002891)1.53859516
184Leiomyosarcoma (HP:0100243)1.53859516
185Abnormality of the lacrimal duct (HP:0011481)1.52619583
186Craniofacial hyperostosis (HP:0004493)1.52514157
187Abnormal cortical bone morphology (HP:0003103)1.52212379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.62270092
2MAP3K143.23042029
3FGFR42.83717142
4LATS22.77178288
5TYK22.71018502
6STK38L2.66123180
7EPHB12.45205023
8TBK12.35532234
9MAP4K12.34336587
10EPHA32.21640143
11ERN12.15486314
12LATS12.15383273
13JAK12.14936646
14TAOK32.07310231
15MST1R2.03413217
16JAK32.01450180
17IKBKE1.99465643
18TXK1.90973163
19TRIB31.89474254
20FGFR31.85559215
21SIK11.73706779
22STK101.70010262
23RIPK11.68134480
24BRD41.67388658
25PKN21.61100944
26ITK1.60964355
27MAP3K31.56260721
28FRK1.52646747
29PTK61.51105892
30SGK21.45444500
31LRRK21.44782503
32TGFBR21.42690674
33FGFR21.42110543
34IKBKB1.39290057
35NEK91.39163734
36STK31.34626475
37CSK1.32205032
38CDK121.31488847
39IRAK31.29901887
40BMX1.29569191
41IRAK21.29423946
42DDR21.28921251
43TEC1.26097010
44IRAK41.25833336
45MST41.22572110
46AKT31.20018596
47TTN1.18987037
48YES11.17704259
49ERBB31.11783457
50BLK1.11308135
51MET1.11192969
52KIT1.10831450
53BMPR21.10528411
54TRPM71.10154404
55CHUK1.09515463
56MKNK11.09279122
57WNK11.07674553
58SGK31.07413317
59MAP3K61.07153245
60ZAP701.06834070
61PIM21.06725939
62JAK21.06527987
63RPS6KA41.06402797
64STK381.06223112
65CDK61.06202864
66MKNK21.03027944
67KSR21.01465647
68MAP3K131.00284374
69EIF2AK20.99786154
70STK240.99201484
71CAMK1D0.95687962
72MAP2K30.94909059
73BTK0.94535573
74BCKDK0.89723798
75NUAK10.87671001
76PIM10.87520155
77LCK0.86459611
78PRKCQ0.83968902
79ERBB40.83542392
80HCK0.83414594
81KSR10.82022775
82PRPF4B0.81496366
83CSF1R0.81299382
84IRAK10.78288617
85PNCK0.77494167
86PBK0.76252274
87SGK2230.75698116
88SGK4940.75698116
89PDGFRB0.73653770
90PIK3CA0.72397072
91RPS6KB10.71788858
92MOS0.71586543
93EEF2K0.71125180
94MAP3K100.70995964
95PIK3CG0.68483044
96MAPK110.67675562
97FGFR10.67189414
98BRSK20.66315022
99NLK0.66073051
100CDK30.65942786
101GSK3A0.64223212
102ABL10.64159298
103TIE10.63978889
104EGFR0.59606243
105KDR0.57499987
106SGK10.57092717
107MELK0.54905482
108SYK0.54386282
109RET0.53574966
110MATK0.53021806
111ACVR1B0.51674410
112CAMK1G0.51571286
113TYRO30.51294151
114ABL20.51211063
115MAPK40.50639832
116IGF1R0.50270162
117STK390.50159777
118MAPK100.50081791
119PRKAA20.49383532
120PRKG20.49252415
121DYRK1B0.48911624
122MAP3K70.48856179
123BCR0.48080597
124EPHA20.47245741
125MARK30.46795466
126PTK20.45304987
127LYN0.45043523
128DMPK0.44203596
129MAP3K40.43804044
130MAP3K20.43422920
131TGFBR10.43117382
132MAP3K10.42228443
133PRKCH0.41867694
134HIPK20.41745424
135MAPK70.40570669
136CASK0.40540352
137GRK60.40276956
138PKN10.40276486
139PAK20.39918212
140CDK90.39854252
141PDGFRA0.38318760
142RAF10.38037079
143FGR0.37286239
144INSR0.36949380
145EPHA40.36663706
146MAP2K40.35055093
147MTOR0.29491938
148MAPK120.28066049
149PRKCE0.27722308
150RPS6KB20.27219578
151MAPK150.24933570

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.36588358
2Nitrogen metabolism_Homo sapiens_hsa009103.11002194
3Staphylococcus aureus infection_Homo sapiens_hsa051502.77169110
4Complement and coagulation cascades_Homo sapiens_hsa046102.74325919
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71403924
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38050872
7Caffeine metabolism_Homo sapiens_hsa002322.34715459
8Arginine biosynthesis_Homo sapiens_hsa002202.24962297
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82343019
10Tryptophan metabolism_Homo sapiens_hsa003801.78691549
11Fatty acid degradation_Homo sapiens_hsa000711.73418167
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70468004
13Leishmaniasis_Homo sapiens_hsa051401.62898339
14Histidine metabolism_Homo sapiens_hsa003401.61370422
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61083854
16PPAR signaling pathway_Homo sapiens_hsa033201.59135513
17Dorso-ventral axis formation_Homo sapiens_hsa043201.58396164
18Chemical carcinogenesis_Homo sapiens_hsa052041.52699161
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49738574
20Peroxisome_Homo sapiens_hsa041461.46407566
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.43209845
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41559893
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.40592318
24Adherens junction_Homo sapiens_hsa045201.36821886
25Malaria_Homo sapiens_hsa051441.36810000
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34360630
27Steroid biosynthesis_Homo sapiens_hsa001001.32049506
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31124746
29Retinol metabolism_Homo sapiens_hsa008301.28031146
30Prolactin signaling pathway_Homo sapiens_hsa049171.27741273
31Osteoclast differentiation_Homo sapiens_hsa043801.24476294
32Renal cell carcinoma_Homo sapiens_hsa052111.24308610
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22250727
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20650924
35Fatty acid metabolism_Homo sapiens_hsa012121.18131268
36Non-small cell lung cancer_Homo sapiens_hsa052231.17422216
37ErbB signaling pathway_Homo sapiens_hsa040121.15108327
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14876240
39Graft-versus-host disease_Homo sapiens_hsa053321.14157131
40Toxoplasmosis_Homo sapiens_hsa051451.12968394
41VEGF signaling pathway_Homo sapiens_hsa043701.10158294
42MicroRNAs in cancer_Homo sapiens_hsa052061.10021115
43Renin secretion_Homo sapiens_hsa049241.08157623
44Pertussis_Homo sapiens_hsa051331.07613847
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06279865
46beta-Alanine metabolism_Homo sapiens_hsa004101.06013660
47Glioma_Homo sapiens_hsa052141.05106083
48mTOR signaling pathway_Homo sapiens_hsa041501.03585484
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03225693
50Bile secretion_Homo sapiens_hsa049761.03009744
51Phenylalanine metabolism_Homo sapiens_hsa003601.02484944
52TNF signaling pathway_Homo sapiens_hsa046681.00985025
53Long-term depression_Homo sapiens_hsa047301.00977066
54Measles_Homo sapiens_hsa051621.00081580
55TGF-beta signaling pathway_Homo sapiens_hsa043500.99443229
56Endometrial cancer_Homo sapiens_hsa052130.99373793
57Propanoate metabolism_Homo sapiens_hsa006400.99263327
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97705626
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.96869594
60ABC transporters_Homo sapiens_hsa020100.96294139
61Choline metabolism in cancer_Homo sapiens_hsa052310.95778767
62FoxO signaling pathway_Homo sapiens_hsa040680.94577817
63Colorectal cancer_Homo sapiens_hsa052100.94427625
64Gap junction_Homo sapiens_hsa045400.92893630
65Long-term potentiation_Homo sapiens_hsa047200.92388573
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.91856278
67Starch and sucrose metabolism_Homo sapiens_hsa005000.91805961
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90192707
69Legionellosis_Homo sapiens_hsa051340.90012734
70Prion diseases_Homo sapiens_hsa050200.89869007
71Prostate cancer_Homo sapiens_hsa052150.89199313
72B cell receptor signaling pathway_Homo sapiens_hsa046620.87994935
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87813040
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87308031
75Fatty acid elongation_Homo sapiens_hsa000620.87232403
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85870956
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85806912
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.85419994
79Circadian rhythm_Homo sapiens_hsa047100.83949199
80Thyroid cancer_Homo sapiens_hsa052160.83401241
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.82906280
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.82431735
83Butanoate metabolism_Homo sapiens_hsa006500.82402320
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.81587877
85Tyrosine metabolism_Homo sapiens_hsa003500.81319334
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.81179198
87Amoebiasis_Homo sapiens_hsa051460.80938123
88Type II diabetes mellitus_Homo sapiens_hsa049300.80698932
89Allograft rejection_Homo sapiens_hsa053300.79762771
90Inositol phosphate metabolism_Homo sapiens_hsa005620.78600060
91GnRH signaling pathway_Homo sapiens_hsa049120.78426429
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77192020
93Fat digestion and absorption_Homo sapiens_hsa049750.76147843
94Hedgehog signaling pathway_Homo sapiens_hsa043400.75946790
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75257091
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74746299
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73981836
98ECM-receptor interaction_Homo sapiens_hsa045120.73890558
99Hematopoietic cell lineage_Homo sapiens_hsa046400.72417214
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72187399
101Sulfur metabolism_Homo sapiens_hsa009200.72069036
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.72033506
103Hepatitis C_Homo sapiens_hsa051600.71494237
104Pathways in cancer_Homo sapiens_hsa052000.71212473
105Estrogen signaling pathway_Homo sapiens_hsa049150.71116616
106Selenocompound metabolism_Homo sapiens_hsa004500.70663669
107Vitamin digestion and absorption_Homo sapiens_hsa049770.70002967
108cAMP signaling pathway_Homo sapiens_hsa040240.69640741
109T cell receptor signaling pathway_Homo sapiens_hsa046600.69384713
110Tuberculosis_Homo sapiens_hsa051520.68896239
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68697096
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67810235
113Melanoma_Homo sapiens_hsa052180.65082293
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64403957
115Wnt signaling pathway_Homo sapiens_hsa043100.64211457
116Platelet activation_Homo sapiens_hsa046110.64009644
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63575287
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63100149
119Primary immunodeficiency_Homo sapiens_hsa053400.62231367
120Bladder cancer_Homo sapiens_hsa052190.62221739
121Lysine degradation_Homo sapiens_hsa003100.62084441
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61875447
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60861455
124Influenza A_Homo sapiens_hsa051640.60829472
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60789765
126HTLV-I infection_Homo sapiens_hsa051660.59902004
127Small cell lung cancer_Homo sapiens_hsa052220.59797290
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58591318
129Insulin resistance_Homo sapiens_hsa049310.57832935
130Tight junction_Homo sapiens_hsa045300.57457793
131Fatty acid biosynthesis_Homo sapiens_hsa000610.57088665
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56867950
133Antigen processing and presentation_Homo sapiens_hsa046120.56643290
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55605215
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.55492592
136Notch signaling pathway_Homo sapiens_hsa043300.55051029
137Sphingolipid metabolism_Homo sapiens_hsa006000.54663608
138Protein digestion and absorption_Homo sapiens_hsa049740.54625271
139Insulin signaling pathway_Homo sapiens_hsa049100.54119950
140Pancreatic cancer_Homo sapiens_hsa052120.53657526
141Hippo signaling pathway_Homo sapiens_hsa043900.53138435
142Apoptosis_Homo sapiens_hsa042100.52232338
143Focal adhesion_Homo sapiens_hsa045100.50763384
144Salmonella infection_Homo sapiens_hsa051320.50504613
145Hepatitis B_Homo sapiens_hsa051610.50352484
146Chemokine signaling pathway_Homo sapiens_hsa040620.49796180
147African trypanosomiasis_Homo sapiens_hsa051430.48570917
148Shigellosis_Homo sapiens_hsa051310.48257192
149Acute myeloid leukemia_Homo sapiens_hsa052210.48120929
150Folate biosynthesis_Homo sapiens_hsa007900.47994278
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47227881
152Viral myocarditis_Homo sapiens_hsa054160.46306035
153Rheumatoid arthritis_Homo sapiens_hsa053230.45494827
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45304927
155Asthma_Homo sapiens_hsa053100.43989734
156Proteoglycans in cancer_Homo sapiens_hsa052050.43268712
157Glycerolipid metabolism_Homo sapiens_hsa005610.41959712
158Chronic myeloid leukemia_Homo sapiens_hsa052200.40667803
159Lysosome_Homo sapiens_hsa041420.39682557
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37881285

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