NAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.81000984
2COPI coating of Golgi vesicle (GO:0048205)4.81000984
3negative regulation of fatty acid transport (GO:2000192)4.08317073
4barbed-end actin filament capping (GO:0051016)4.05979131
5protein heterotrimerization (GO:0070208)3.81439610
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.79819647
7endothelial cell chemotaxis (GO:0035767)3.67989767
8positive regulation of endothelial cell apoptotic process (GO:2000353)3.67175673
9apoptotic cell clearance (GO:0043277)3.64061339
10skin morphogenesis (GO:0043589)3.58962305
11chondrocyte proliferation (GO:0035988)3.58428110
12endodermal cell differentiation (GO:0035987)3.52697105
13collagen fibril organization (GO:0030199)3.47452733
14regulation of early endosome to late endosome transport (GO:2000641)3.42984790
15regulation of interleukin-12 biosynthetic process (GO:0045075)3.40724172
16cell adhesion mediated by integrin (GO:0033627)3.37080582
17regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36801371
18positive thymic T cell selection (GO:0045059)3.36127341
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21378030
20adhesion of symbiont to host (GO:0044406)3.19076521
21adhesion of symbiont to host cell (GO:0044650)3.18970863
22virion attachment to host cell (GO:0019062)3.18970863
23cell migration involved in sprouting angiogenesis (GO:0002042)3.17003344
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.15183636
25semaphorin-plexin signaling pathway (GO:0071526)3.13252587
26regulation of tight junction assembly (GO:2000810)3.06998660
27response to laminar fluid shear stress (GO:0034616)3.00913505
28hemidesmosome assembly (GO:0031581)2.99194587
29positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98835866
30stress fiber assembly (GO:0043149)2.98501150
31regulation of gamma-delta T cell differentiation (GO:0045586)2.97800016
32regulation of extracellular matrix disassembly (GO:0010715)2.97746376
33axon extension involved in axon guidance (GO:0048846)2.96825723
34neuron projection extension involved in neuron projection guidance (GO:1902284)2.96825723
35positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.96733118
36positive regulation of histone deacetylation (GO:0031065)2.92453661
37mannose metabolic process (GO:0006013)2.92250744
38decidualization (GO:0046697)2.89744267
39blood vessel endothelial cell migration (GO:0043534)2.88991666
40protein retention in ER lumen (GO:0006621)2.88955307
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87899483
42activation of MAPKKK activity (GO:0000185)2.83314743
43epithelial cell-cell adhesion (GO:0090136)2.83225829
44wound healing, spreading of epidermal cells (GO:0035313)2.80110265
45mammary gland epithelial cell proliferation (GO:0033598)2.79782271
46bone trabecula formation (GO:0060346)2.79047551
47focal adhesion assembly (GO:0048041)2.78924183
48thymic T cell selection (GO:0045061)2.77706013
49activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76721460
50positive regulation of gamma-delta T cell activation (GO:0046645)2.75951653
51cell-cell junction maintenance (GO:0045217)2.72289366
52cell migration involved in heart development (GO:0060973)2.72166028
53regulation of extracellular matrix organization (GO:1903053)2.72151248
54regulation of gamma-delta T cell activation (GO:0046643)2.70688290
55pinocytosis (GO:0006907)2.70597125
56positive regulation of epithelial to mesenchymal transition (GO:0010718)2.70061897
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69767733
58positive regulation of natural killer cell differentiation (GO:0032825)2.68359895
59positive regulation of fibroblast migration (GO:0010763)2.68111844
60regulation of NFAT protein import into nucleus (GO:0051532)2.66246926
61substrate-dependent cell migration (GO:0006929)2.65143714
62regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64363636
63regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64355906
64response to fluid shear stress (GO:0034405)2.63452943
65positive regulation of axon extension (GO:0045773)2.61590385
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61182583
67positive regulation of nuclease activity (GO:0032075)2.60726982
68negative thymic T cell selection (GO:0045060)2.59247330
69branching involved in mammary gland duct morphogenesis (GO:0060444)2.58576675
70actin filament bundle organization (GO:0061572)2.58421553
71actin filament bundle assembly (GO:0051017)2.58421553
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57741671
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57023751
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57023751
75protein localization to endosome (GO:0036010)2.56936064
76collagen metabolic process (GO:0032963)2.56718420
77endocytic recycling (GO:0032456)2.55972324
78positive T cell selection (GO:0043368)2.55592002
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.55516510
80regulation of integrin activation (GO:0033623)2.55367667
81embryo implantation (GO:0007566)2.54948656
82positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.54398128
83endoplasmic reticulum unfolded protein response (GO:0030968)2.53176049
84regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53106102
85hyaluronan catabolic process (GO:0030214)2.51981690
86positive regulation of keratinocyte differentiation (GO:0045618)2.51911368
87adherens junction assembly (GO:0034333)2.51501785
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51287534
89extracellular matrix assembly (GO:0085029)2.50760991
90collagen catabolic process (GO:0030574)2.50739483
91germ cell migration (GO:0008354)2.49973668
92cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.49328794
93tyrosine phosphorylation of STAT protein (GO:0007260)2.48581227
94negative T cell selection (GO:0043383)2.48355284
95heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.47682472
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47023423
97growth hormone receptor signaling pathway (GO:0060396)2.46814177
98chondroitin sulfate biosynthetic process (GO:0030206)2.46375083
99type B pancreatic cell proliferation (GO:0044342)2.45984196
100negative regulation of focal adhesion assembly (GO:0051895)2.44677582
101negative regulation of cell junction assembly (GO:1901889)2.44677582
102negative regulation of adherens junction organization (GO:1903392)2.44677582
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.44370640
104NIK/NF-kappaB signaling (GO:0038061)2.44182274
105positive regulation of astrocyte differentiation (GO:0048711)2.44120124
106cell-substrate junction assembly (GO:0007044)2.44060326
107outer ear morphogenesis (GO:0042473)2.43904012
108surfactant homeostasis (GO:0043129)2.43741473
109positive regulation of extracellular matrix organization (GO:1903055)2.43675444
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43393445
111kidney mesenchyme development (GO:0072074)2.42754337
112craniofacial suture morphogenesis (GO:0097094)2.42370041
113cell proliferation involved in metanephros development (GO:0072203)2.42062442
114glomerular visceral epithelial cell development (GO:0072015)2.41841536
115ER-nucleus signaling pathway (GO:0006984)2.41328239
116atrioventricular valve morphogenesis (GO:0003181)2.40913138
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40865074
118multicellular organismal macromolecule metabolic process (GO:0044259)2.40853799
119glial cell migration (GO:0008347)2.39947080
120negative regulation of erythrocyte differentiation (GO:0045647)2.39907364
121positive regulation of p38MAPK cascade (GO:1900745)2.39228250
122regulation of mammary gland epithelial cell proliferation (GO:0033599)2.38953535
123positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38917260
124cellular response to arsenic-containing substance (GO:0071243)2.38043387
125heparan sulfate proteoglycan metabolic process (GO:0030201)2.37867037
126vesicle coating (GO:0006901)2.37844015
127negative regulation of interleukin-2 production (GO:0032703)2.37721843
128substrate adhesion-dependent cell spreading (GO:0034446)2.37580689
129vascular endothelial growth factor signaling pathway (GO:0038084)2.37457297
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37097403
131negative regulation of lipid transport (GO:0032369)2.36285462
132sequestering of extracellular ligand from receptor (GO:0035581)2.35321972
133basement membrane organization (GO:0071711)2.34271531
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.33320648
135mRNA transcription (GO:0009299)2.29645968
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.28632140
137T cell selection (GO:0045058)2.28193857
138plasma membrane repair (GO:0001778)2.28145779
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.27780943
140multicellular organismal catabolic process (GO:0044243)2.26774799
141NLS-bearing protein import into nucleus (GO:0006607)2.26675074
142negative regulation of chondrocyte differentiation (GO:0032331)2.26617945
143natural killer cell differentiation (GO:0001779)2.26022843
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25550844
145regulation of fatty acid beta-oxidation (GO:0031998)2.23910943
146multicellular organismal metabolic process (GO:0044236)2.22266697
147regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21738222
148protein localization to cell surface (GO:0034394)2.20071340
149anatomical structure regression (GO:0060033)2.18802178
150hippo signaling (GO:0035329)2.17917262
151cortical actin cytoskeleton organization (GO:0030866)2.17208911
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.16706322
153glomerular basement membrane development (GO:0032836)2.16592762
154extracellular matrix disassembly (GO:0022617)2.15870869
155regulation of macrophage cytokine production (GO:0010935)2.15829090
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15815933
157face morphogenesis (GO:0060325)2.14614345
158wound healing, spreading of cells (GO:0044319)2.14117600
159regulation of vitamin D biosynthetic process (GO:0060556)2.14106627
160regulation of T cell tolerance induction (GO:0002664)2.13068617
161T cell apoptotic process (GO:0070231)2.12591841
162antigen processing and presentation via MHC class Ib (GO:0002475)2.12435008
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.11941907
164cell-substrate adherens junction assembly (GO:0007045)2.11804410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.17468266
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.64850604
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.51369298
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.42675551
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19317072
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89593400
7* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.67914661
8MYC_22102868_ChIP-Seq_BL_Human2.56986197
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46370512
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.37501200
11* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27319936
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.25030879
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.24616382
14* KDM2B_26808549_Chip-Seq_DND41_Human2.21966671
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11484177
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04456262
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04077679
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99279050
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92961481
20* LXR_22292898_ChIP-Seq_THP-1_Human1.88395202
21ZNF263_19887448_ChIP-Seq_K562_Human1.86225583
22* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85202997
23CLOCK_20551151_ChIP-Seq_293T_Human1.82531783
24VDR_21846776_ChIP-Seq_THP-1_Human1.79793445
25* KDM2B_26808549_Chip-Seq_JURKAT_Human1.77213058
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76198256
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66281733
28* KDM2B_26808549_Chip-Seq_K562_Human1.65113878
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61793409
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.61090982
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60969391
32* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60609545
33* MAF_26560356_Chip-Seq_TH1_Human1.58685940
34* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58109453
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56420758
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.54571535
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54340360
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53209858
39RUNX_20019798_ChIP-Seq_JUKART_Human1.52922939
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52714052
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50923660
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50867009
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46811602
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45446118
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43637384
46* UTX_26944678_Chip-Seq_JUKART_Human1.43350776
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.42118809
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39001590
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38462784
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37009942
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36987292
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36333743
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35815504
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35539610
55ATF3_27146783_Chip-Seq_COLON_Human1.35070638
56* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34616057
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34123740
58VDR_24763502_ChIP-Seq_THP-1_Human1.34036124
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32575070
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30011864
61* BRD4_25478319_ChIP-Seq_HGPS_Human1.28834314
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28795437
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28303823
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.27913787
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26446479
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25486500
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24984910
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.24699474
69SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22084624
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21537195
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21079715
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.20521821
73IRF8_27001747_Chip-Seq_BMDM_Mouse1.20460384
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.20391367
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19831496
76SPI1_23127762_ChIP-Seq_K562_Human1.19762932
77* NCOR1_26117541_ChIP-Seq_K562_Human1.19205170
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18634860
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18560411
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18004993
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17325360
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16332128
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.15711695
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15528803
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15105344
86* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14866661
87* TP53_22127205_ChIP-Seq_IMR90_Human1.14450696
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14016171
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.13924597
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13004382
91CJUN_26792858_Chip-Seq_BT549_Human1.12037383
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12028281
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11855634
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11811247
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10971887
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09647797
97IRF8_22096565_ChIP-ChIP_GC-B_Human1.09305998
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.09301214
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.08084499
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.07955955
101MYB_26560356_Chip-Seq_TH2_Human1.07621030
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07576633
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07315856
104* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06981692
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05607009
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05141876
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05021765
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04147061
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03930455
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03881608
111KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03834528
112SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03056323
113* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02231903
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.02199112
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01884940
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01301224
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01052624
118* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00924409
119* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99599033
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99532458
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99504893
122* MYB_26560356_Chip-Seq_TH1_Human0.99159004
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98698516
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.98144250
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97965651
126TP53_16413492_ChIP-PET_HCT116_Human0.97365710
127* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96950395
128* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96950395
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95637715
130* CREB1_26743006_Chip-Seq_LNCaP_Human0.95370918
131MAF_26560356_Chip-Seq_TH2_Human0.93904138
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93303242
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92328125
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91000614
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.89548292
136SMC4_20622854_ChIP-Seq_HELA_Human0.89526625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.78484588
2MP0003705_abnormal_hypodermis_morpholog4.45906053
3MP0003300_gastrointestinal_ulcer3.37736551
4MP0003279_aneurysm2.99016759
5MP0005275_abnormal_skin_tensile2.90557239
6MP0005503_abnormal_tendon_morphology2.78992672
7MP0000569_abnormal_digit_pigmentation2.72795735
8MP0009780_abnormal_chondrocyte_physiolo2.66146014
9MP0005623_abnormal_meninges_morphology2.64492727
10MP0003566_abnormal_cell_adhesion2.54521786
11MP0002254_reproductive_system_inflammat2.53121320
12MP0001958_emphysema2.38301503
13MP0009840_abnormal_foam_cell2.31348864
14MP0003091_abnormal_cell_migration2.30893117
15MP0005076_abnormal_cell_differentiation2.25072349
16MP0010352_gastrointestinal_tract_polyps2.16328737
17MP0003303_peritoneal_inflammation2.13675092
18MP0005023_abnormal_wound_healing2.06131884
19MP0001542_abnormal_bone_strength1.99261588
20MP0000733_abnormal_muscle_development1.95837055
21MP0004510_myositis1.93519611
22MP0003045_fibrosis1.92821675
23MP0009278_abnormal_bone_marrow1.90956358
24MP0009384_cardiac_valve_regurgitation1.86886276
25MP0003436_decreased_susceptibility_to1.81463486
26MP0005257_abnormal_intraocular_pressure1.77809496
27MP0000685_abnormal_immune_system1.71223497
28MP0005508_abnormal_skeleton_morphology1.63599384
29MP0004808_abnormal_hematopoietic_stem1.58854209
30MP0004272_abnormal_basement_membrane1.50674855
31MP0000767_abnormal_smooth_muscle1.49829519
32MP0002998_abnormal_bone_remodeling1.48428509
33MP0008260_abnormal_autophagy1.46009157
34MP0002933_joint_inflammation1.45788568
35MP0002796_impaired_skin_barrier1.43513839
36MP0000750_abnormal_muscle_regeneration1.42124452
37MP0005171_absent_coat_pigmentation1.40628405
38MP0004947_skin_inflammation1.39484854
39MP0008961_abnormal_basal_metabolism1.36539173
40MP0003385_abnormal_body_wall1.35629385
41MP0010368_abnormal_lymphatic_system1.35045396
42MP0005451_abnormal_body_composition1.34546227
43MP0002877_abnormal_melanocyte_morpholog1.34296225
44MP0002060_abnormal_skin_morphology1.33980643
45MP0010030_abnormal_orbit_morphology1.33670457
46MP0005390_skeleton_phenotype1.33407098
47MP0001533_abnormal_skeleton_physiology1.30502168
48MP0009053_abnormal_anal_canal1.29571498
49MP0003941_abnormal_skin_development1.29482013
50MP0004381_abnormal_hair_follicle1.27334279
51MP0003950_abnormal_plasma_membrane1.26022104
52MP0003453_abnormal_keratinocyte_physiol1.25293651
53MP0001348_abnormal_lacrimal_gland1.22771020
54MP0002089_abnormal_postnatal_growth/wei1.22107915
55MP0003448_altered_tumor_morphology1.18751559
56MP0001243_abnormal_dermal_layer1.16849547
57MP0000858_altered_metastatic_potential1.16023276
58MP0006054_spinal_hemorrhage1.15130304
59MP0002168_other_aberrant_phenotype1.14608098
60MP0003763_abnormal_thymus_physiology1.14063351
61MP0000579_abnormal_nail_morphology1.12697886
62MP0005387_immune_system_phenotype1.12671365
63MP0001790_abnormal_immune_system1.12671365
64MP0000534_abnormal_ureter_morphology1.08877072
65MP0003942_abnormal_urinary_system1.08572625
66MP0003634_abnormal_glial_cell1.08449573
67MP0002098_abnormal_vibrissa_morphology1.07563081
68MP0001216_abnormal_epidermal_layer1.07465893
69MP0002295_abnormal_pulmonary_circulatio1.06960829
70MP0002405_respiratory_system_inflammati1.05825476
71MP0006082_CNS_inflammation1.05816784
72MP0005595_abnormal_vascular_smooth1.05717933
73MP0003795_abnormal_bone_structure1.03215601
74MP0005501_abnormal_skin_physiology1.01650410
75MP0002896_abnormal_bone_mineralization1.01295612
76MP0002115_abnormal_skeleton_extremities1.00329387
77MP0001849_ear_inflammation0.99332848
78MP0002113_abnormal_skeleton_development0.98754825
79MP0005423_abnormal_somatic_nervous0.98598570
80MP0003329_amyloid_beta_deposits0.98396873
81MP0000751_myopathy0.98078737
82MP0005409_darkened_coat_color0.97983819
83MP0004858_abnormal_nervous_system0.95693612
84MP0000467_abnormal_esophagus_morphology0.95650613
85MP0000537_abnormal_urethra_morphology0.94013997
86MP0002932_abnormal_joint_morphology0.93506067
87MP0009333_abnormal_splenocyte_physiolog0.92753066
88MP0009250_abnormal_appendicular_skeleto0.91685771
89MP0000428_abnormal_craniofacial_morphol0.91635090
90MP0004233_abnormal_muscle_weight0.91209516
91MP0002128_abnormal_blood_circulation0.90636889
92MP0003115_abnormal_respiratory_system0.90446595
93MP0005464_abnormal_platelet_physiology0.90237698
94MP0002282_abnormal_trachea_morphology0.89541180
95MP0005397_hematopoietic_system_phenotyp0.89392944
96MP0001545_abnormal_hematopoietic_system0.89392944
97MP0005058_abnormal_lysosome_morphology0.89336907
98MP0005000_abnormal_immune_tolerance0.89200330
99MP0000681_abnormal_thyroid_gland0.87139654
100MP0010307_abnormal_tumor_latency0.85691717
101MP0001800_abnormal_humoral_immune0.85690352
102MP0000343_altered_response_to0.85612957
103MP0002452_abnormal_antigen_presenting0.84663690
104MP0000003_abnormal_adipose_tissue0.83138526
105MP0002925_abnormal_cardiovascular_devel0.82891871
106MP0005248_abnormal_Harderian_gland0.82352292
107MP0001614_abnormal_blood_vessel0.81846540
108MP0000759_abnormal_skeletal_muscle0.81803685
109MP0009931_abnormal_skin_appearance0.81120367
110MP0010771_integument_phenotype0.81018501
111MP0001915_intracranial_hemorrhage0.80427190
112MP0003878_abnormal_ear_physiology0.80079644
113MP0005377_hearing/vestibular/ear_phenot0.80079644
114MP0000163_abnormal_cartilage_morphology0.78769378
115MP0002396_abnormal_hematopoietic_system0.77924313
116MP0003191_abnormal_cellular_cholesterol0.77451982
117MP0010234_abnormal_vibrissa_follicle0.77311081
118MP0005197_abnormal_uvea_morphology0.77104865
119MP0002108_abnormal_muscle_morphology0.76197420
120MP0003172_abnormal_lysosome_physiology0.76112292
121MP0000377_abnormal_hair_follicle0.75424737
122MP0000762_abnormal_tongue_morphology0.75133466
123MP0002166_altered_tumor_susceptibility0.74763707
124MP0002249_abnormal_larynx_morphology0.74531469
125MP0001299_abnormal_eye_distance/0.74363726
126MP0008004_abnormal_stomach_pH0.73973904
127MP0000604_amyloidosis0.71568076
128MP0002723_abnormal_immune_serum0.71568010
129MP0000432_abnormal_head_morphology0.71162684
130MP0001851_eye_inflammation0.71064994
131MP0005671_abnormal_response_to0.71058385
132MP0003828_pulmonary_edema0.70606252
133MP0000703_abnormal_thymus_morphology0.69774974
134MP0003755_abnormal_palate_morphology0.69062835
135MP0002109_abnormal_limb_morphology0.68750571
136MP0003935_abnormal_craniofacial_develop0.67476753
137MP0000678_abnormal_parathyroid_gland0.67339302
138MP0002116_abnormal_craniofacial_bone0.66138221
139MP0001175_abnormal_lung_morphology0.64470830
140MP0000920_abnormal_myelination0.63070626
141MP0000747_muscle_weakness0.62929654
142MP0003075_altered_response_to0.62562859

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.21615962
2Premature rupture of membranes (HP:0001788)5.26111281
3Shallow orbits (HP:0000586)4.47311459
4Cerebral aneurysm (HP:0004944)4.09591282
5Peritonitis (HP:0002586)4.04006757
6Aortic dissection (HP:0002647)3.87035166
7Ankle contracture (HP:0006466)3.61271441
8Aortic aneurysm (HP:0004942)3.47053749
9Dilatation of the ascending aorta (HP:0005111)3.44932745
10Mitral valve prolapse (HP:0001634)3.35082204
11Broad metatarsal (HP:0001783)3.33845325
12Follicular hyperkeratosis (HP:0007502)3.19745600
13Genu recurvatum (HP:0002816)3.18665946
14Atrophic scars (HP:0001075)3.05651194
15Cervical subluxation (HP:0003308)3.03238171
16Increased density of long bones (HP:0006392)2.96188794
17Bladder diverticulum (HP:0000015)2.88313251
18Distal lower limb muscle weakness (HP:0009053)2.73461164
19Fragile skin (HP:0001030)2.65293287
20Abnormality of glycolipid metabolism (HP:0010969)2.65016763
21Abnormality of liposaccharide metabolism (HP:0010968)2.65016763
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.65016763
23Alopecia of scalp (HP:0002293)2.61840444
24Stridor (HP:0010307)2.61261483
25Natal tooth (HP:0000695)2.59923415
26Neonatal short-limb short stature (HP:0008921)2.59724339
27Soft skin (HP:0000977)2.57185734
28Ulnar bowing (HP:0003031)2.55884325
29Vertebral compression fractures (HP:0002953)2.55053624
30Blue sclerae (HP:0000592)2.54197231
31Syringomyelia (HP:0003396)2.54071786
32Spinal cord lesions (HP:0100561)2.54071786
33Aneurysm (HP:0002617)2.50814740
34Distal upper limb amyotrophy (HP:0007149)2.48339568
35Upper limb amyotrophy (HP:0009129)2.48339568
36J-shaped sella turcica (HP:0002680)2.44868003
37Increased connective tissue (HP:0009025)2.39584174
38Type 1 muscle fiber predominance (HP:0003803)2.38627131
39Turricephaly (HP:0000262)2.37963997
40Biconcave vertebral bodies (HP:0004586)2.37085157
41Myocardial infarction (HP:0001658)2.34578549
42Abnormality of the peritoneum (HP:0002585)2.33998087
43Insomnia (HP:0100785)2.31287461
44Deviation of the hallux (HP:0010051)2.30804857
45Dysostosis multiplex (HP:0000943)2.29956949
46Vascular tortuosity (HP:0004948)2.28916168
47Axonal loss (HP:0003447)2.25634568
48Camptodactyly of toe (HP:0001836)2.25143531
49Nuclear cataract (HP:0100018)2.22738121
50Hallux valgus (HP:0001822)2.22394127
51Abnormality of dentin (HP:0010299)2.21095532
52Radial bowing (HP:0002986)2.19178903
53Striae distensae (HP:0001065)2.19027746
54Neurofibrillary tangles (HP:0002185)2.17092164
55Bowel diverticulosis (HP:0005222)2.14533611
56Persistence of primary teeth (HP:0006335)2.14429014
57Wormian bones (HP:0002645)2.14055754
58Long palpebral fissure (HP:0000637)2.13715731
59Bowing of the arm (HP:0006488)2.13205180
60Bowed forearm bones (HP:0003956)2.13205180
61Generalized amyotrophy (HP:0003700)2.13006276
62Increased cerebral lipofuscin (HP:0011813)2.12866256
63Renal duplication (HP:0000075)2.12204557
64Arterial tortuosity (HP:0005116)2.12079428
65Slender build (HP:0001533)2.11133095
66Abnormality of the acetabulum (HP:0003170)2.09146265
67Ectopia lentis (HP:0001083)2.08274105
68Spinal rigidity (HP:0003306)2.07988856
69Distal lower limb amyotrophy (HP:0008944)2.07805915
70Mildly elevated creatine phosphokinase (HP:0008180)2.06640040
71Asymmetry of the thorax (HP:0001555)2.05950108
72Achilles tendon contracture (HP:0001771)2.04801995
73Coronal craniosynostosis (HP:0004440)2.04750725
74Elbow flexion contracture (HP:0002987)2.03410306
75Premature skin wrinkling (HP:0100678)2.02382549
76Mitral regurgitation (HP:0001653)2.02125037
77Diaphragmatic weakness (HP:0009113)2.01197978
78Mesomelia (HP:0003027)2.01040145
79Joint stiffness (HP:0001387)2.00454889
80Osteolytic defects of the hand bones (HP:0009699)1.99497558
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.99497558
82Bilateral sensorineural hearing impairment (HP:0008619)1.99418467
83Obstructive sleep apnea (HP:0002870)1.98978715
84Hypoventilation (HP:0002791)1.98637753
85Hyperextensible skin (HP:0000974)1.97597542
86Wrist flexion contracture (HP:0001239)1.96042711
87Thin ribs (HP:0000883)1.93873050
88Disproportionate tall stature (HP:0001519)1.92598549
89Thin bony cortex (HP:0002753)1.92060408
90Hand muscle atrophy (HP:0009130)1.91337992
91Increased variability in muscle fiber diameter (HP:0003557)1.91134409
92Abnormality of the Achilles tendon (HP:0005109)1.91127196
93Abnormal delivery (HP:0001787)1.90368052
94Vacuolated lymphocytes (HP:0001922)1.89941977
95Broad face (HP:0000283)1.89758891
96Dislocated radial head (HP:0003083)1.87846047
97Mucopolysacchariduria (HP:0008155)1.87411991
98Urinary glycosaminoglycan excretion (HP:0003541)1.87411991
99Abnormality of polysaccharide metabolism (HP:0011012)1.86540992
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86540992
101Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86540992
102Cerebral inclusion bodies (HP:0100314)1.85325255
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82195487
104Short 4th metacarpal (HP:0010044)1.82195487
105Abnormality of the distal phalanges of the toes (HP:0010182)1.82075824
106Eczematoid dermatitis (HP:0000976)1.80754377
107Subacute progressive viral hepatitis (HP:0006572)1.80046499
108Mitral stenosis (HP:0001718)1.79798495
109Abnormal gallbladder physiology (HP:0012438)1.79691219
110Cholecystitis (HP:0001082)1.79691219
111Short nail (HP:0001799)1.78827030
112Abnormality of the radial head (HP:0003995)1.77260697
113Abnormality of skeletal muscle fiber size (HP:0012084)1.77144176
114Joint laxity (HP:0001388)1.77026966
115Joint contractures involving the joints of the feet (HP:0100492)1.76113384
116Flexion contracture of toe (HP:0005830)1.76113384
117Congenital glaucoma (HP:0001087)1.74856147
118Buphthalmos (HP:0000557)1.74466927
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.73913978
120Elevated erythrocyte sedimentation rate (HP:0003565)1.73383170
121Inguinal hernia (HP:0000023)1.73289991
122Rectal prolapse (HP:0002035)1.72481019
123Enlarged penis (HP:0000040)1.70768877
124Thick nail (HP:0001805)1.70049794
125Lower limb amyotrophy (HP:0007210)1.69537149
126Hammertoe (HP:0001765)1.69524300
127Long toe (HP:0010511)1.69505944
128Upper limb muscle weakness (HP:0003484)1.69147094
129Advanced eruption of teeth (HP:0006288)1.68997183
130Aortic regurgitation (HP:0001659)1.68907881
131Overriding aorta (HP:0002623)1.67668542
132Flat cornea (HP:0007720)1.67296518
133Spondylolisthesis (HP:0003302)1.67023125
134Difficulty climbing stairs (HP:0003551)1.66365937
135Loss of speech (HP:0002371)1.66262751
136Wide anterior fontanel (HP:0000260)1.64564635
137Overgrowth (HP:0001548)1.64466697
138Hematochezia (HP:0002573)1.62796845
139Broad long bones (HP:0005622)1.62791854
140Tibial bowing (HP:0002982)1.62525777
141Hyperacusis (HP:0010780)1.61481126
142Arterial thrombosis (HP:0004420)1.60476433
143Stomatitis (HP:0010280)1.58045822
144Lymphangioma (HP:0100764)1.56639239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.39252937
2PRPF4B3.68440648
3IRAK33.60660928
4PKN22.92503276
5ERN12.82513167
6EEF2K2.78204268
7SIK12.69244148
8DDR22.53232890
9PDGFRA2.38190517
10MAP3K102.33785822
11TTN2.31302745
12MAP4K12.16943882
13NME22.09344904
14RIPK12.01270974
15LATS11.99079944
16SMG11.95450866
17CDK121.95334455
18TESK11.94650220
19FGFR41.86879584
20BMX1.81402443
21EPHA21.77156564
22EPHA31.64251888
23PTK61.62195126
24EPHB11.61031899
25NTRK11.60102205
26JAK31.54565296
27RPS6KA41.52867790
28LATS21.50032670
29TAOK11.49487739
30SIK21.46852564
31PAK41.40971456
32ZAP701.40079816
33DMPK1.34199557
34TGFBR21.33396027
35TXK1.30593200
36MUSK1.30532230
37FGFR31.27723537
38LIMK11.26700427
39JAK11.20561576
40LRRK21.20391705
41TYRO31.20254488
42RPS6KA21.15005108
43PDGFRB1.14789679
44STK101.12449175
45PAK21.12238382
46ALK1.11113735
47MOS1.08359979
48MAP3K71.07538413
49TBK11.05101676
50FGFR11.03301931
51CHUK1.03226799
52PTK21.01977346
53MAPKAPK31.01881621
54HCK1.01668074
55SIK31.01165845
56CDC42BPA1.01061436
57MYLK0.99942884
58CAMK1D0.99463348
59ABL20.98603332
60ICK0.98123383
61PRKCH0.96727515
62MTOR0.90119071
63PRKD30.88436849
64CSK0.88248274
65PRKD20.87972787
66CAMKK10.87438361
67MARK20.85755112
68TYK20.85521125
69PTK2B0.85441933
70EPHB20.85267475
71FER0.82069518
72ITK0.82024927
73MAP3K140.81576849
74IKBKB0.81388590
75STK30.80947786
76MAP2K30.80513582
77CAMK1G0.79797329
78MAP3K110.79008069
79RET0.77538004
80ROCK20.75519336
81KIT0.74205200
82ARAF0.73786368
83PIM20.73752299
84TAOK20.72523839
85SCYL20.71919058
86MAP3K90.70924379
87CDK60.70716479
88DAPK30.70310224
89MAP3K130.70213548
90RPS6KL10.68542993
91RPS6KC10.68542993
92ILK0.64941514
93MARK30.64502652
94ERBB40.62355434
95CAMK40.62269077
96STK380.61178995
97MAP3K10.59486704
98IKBKE0.59403806
99KSR20.58330282
100CDK150.57751065
101TRPM70.57025943
102INSR0.56203936
103TNK20.54981337
104CDK180.54848238
105MARK10.54832240
106PAK60.52400984
107MAP3K30.51409777
108CDK11A0.51240921
109ROCK10.49997288
110JAK20.48178395
111TSSK60.45874832
112CAMK2G0.45208092
113RPS6KB20.44349959
114PRKD10.43946140
115GSK3A0.43604246
116LMTK20.43553730
117AKT20.42528365
118CDK140.42421255
119MAP3K60.41387660
120GRK60.40758510
121CSF1R0.40743187
122PDPK10.40693372
123PIM10.40322911
124LCK0.40255378
125RPS6KA60.40106297
126MST1R0.39954187
127MAPK40.39838955
128IRAK20.39404879
129NEK90.39305625
130MET0.38290438
131CDK40.38224094
132TESK20.38125328
133CDK70.38011498
134EGFR0.37394593
135CLK10.37005428
136SGK30.36899760
137CDK90.36829008
138PAK30.36234799
139NLK0.36043588
140SRC0.35589184
141MAP3K80.34887373
142PRKG20.34830128
143RPS6KA10.34208196
144MAP2K10.32244441
145HIPK20.29966221
146MAPK10.29755416

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.55477497
2Lysosome_Homo sapiens_hsa041422.06715221
3Prion diseases_Homo sapiens_hsa050201.83544636
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82546326
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81622820
6Chronic myeloid leukemia_Homo sapiens_hsa052201.78936822
7ECM-receptor interaction_Homo sapiens_hsa045121.75045849
8Focal adhesion_Homo sapiens_hsa045101.72181455
9Proteoglycans in cancer_Homo sapiens_hsa052051.64932459
10Osteoclast differentiation_Homo sapiens_hsa043801.59958685
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58889960
12T cell receptor signaling pathway_Homo sapiens_hsa046601.51089587
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49442365
14Leishmaniasis_Homo sapiens_hsa051401.47459092
15Vibrio cholerae infection_Homo sapiens_hsa051101.46943543
16Amoebiasis_Homo sapiens_hsa051461.45461685
17Adherens junction_Homo sapiens_hsa045201.44423249
18Bladder cancer_Homo sapiens_hsa052191.39781104
19Pancreatic cancer_Homo sapiens_hsa052121.39639413
20Small cell lung cancer_Homo sapiens_hsa052221.35246070
21TNF signaling pathway_Homo sapiens_hsa046681.34962420
22Toxoplasmosis_Homo sapiens_hsa051451.34696848
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.31347217
24Acute myeloid leukemia_Homo sapiens_hsa052211.28788421
25Shigellosis_Homo sapiens_hsa051311.28441554
26Malaria_Homo sapiens_hsa051441.27257672
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27045971
28MicroRNAs in cancer_Homo sapiens_hsa052061.22701105
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20868164
30Glioma_Homo sapiens_hsa052141.18279941
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17945518
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17880133
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15483496
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.15284481
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14768976
36B cell receptor signaling pathway_Homo sapiens_hsa046621.14354460
37Viral myocarditis_Homo sapiens_hsa054161.13232762
38Hepatitis B_Homo sapiens_hsa051611.13107710
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.12719449
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11441421
41Prolactin signaling pathway_Homo sapiens_hsa049171.11214180
42HTLV-I infection_Homo sapiens_hsa051661.11154642
43VEGF signaling pathway_Homo sapiens_hsa043701.10849291
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10554993
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08895290
46Measles_Homo sapiens_hsa051621.08325050
47mTOR signaling pathway_Homo sapiens_hsa041501.08256229
48Platelet activation_Homo sapiens_hsa046111.08154152
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04646206
50Non-small cell lung cancer_Homo sapiens_hsa052231.04126733
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.02857393
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00706855
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00367265
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00224794
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00064763
56Rap1 signaling pathway_Homo sapiens_hsa040150.98778896
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.98315201
58Tuberculosis_Homo sapiens_hsa051520.97028925
59Notch signaling pathway_Homo sapiens_hsa043300.96796807
60Pentose phosphate pathway_Homo sapiens_hsa000300.96708153
61Apoptosis_Homo sapiens_hsa042100.94967793
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.91605483
63Salmonella infection_Homo sapiens_hsa051320.91242016
64Colorectal cancer_Homo sapiens_hsa052100.90841460
65Staphylococcus aureus infection_Homo sapiens_hsa051500.89672184
66Dilated cardiomyopathy_Homo sapiens_hsa054140.89519501
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.89291449
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89251448
69Hepatitis C_Homo sapiens_hsa051600.88787978
70Primary immunodeficiency_Homo sapiens_hsa053400.87850611
71TGF-beta signaling pathway_Homo sapiens_hsa043500.87114566
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85470068
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85326124
74Allograft rejection_Homo sapiens_hsa053300.85172403
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85135963
76Sphingolipid metabolism_Homo sapiens_hsa006000.84980075
77Fructose and mannose metabolism_Homo sapiens_hsa000510.84895704
78Hippo signaling pathway_Homo sapiens_hsa043900.84175025
79Endometrial cancer_Homo sapiens_hsa052130.82694002
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.82403991
81Insulin signaling pathway_Homo sapiens_hsa049100.81362695
82Synaptic vesicle cycle_Homo sapiens_hsa047210.81300055
83Axon guidance_Homo sapiens_hsa043600.81069444
84Prostate cancer_Homo sapiens_hsa052150.79307678
85Chemokine signaling pathway_Homo sapiens_hsa040620.79048042
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.78482225
87Insulin resistance_Homo sapiens_hsa049310.78048237
88HIF-1 signaling pathway_Homo sapiens_hsa040660.77495460
89MAPK signaling pathway_Homo sapiens_hsa040100.77468619
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77127286
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77027997
92Melanogenesis_Homo sapiens_hsa049160.76446869
93Protein digestion and absorption_Homo sapiens_hsa049740.76039957
94Renal cell carcinoma_Homo sapiens_hsa052110.75752417
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75115243
96Vitamin B6 metabolism_Homo sapiens_hsa007500.74436088
97Legionellosis_Homo sapiens_hsa051340.74178207
98Pertussis_Homo sapiens_hsa051330.73171151
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.72763884
100Phagosome_Homo sapiens_hsa041450.72434739
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71386423
102ErbB signaling pathway_Homo sapiens_hsa040120.71357702
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70657186
104Pathways in cancer_Homo sapiens_hsa052000.70017281
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69843587
106GnRH signaling pathway_Homo sapiens_hsa049120.69655293
107Estrogen signaling pathway_Homo sapiens_hsa049150.69127085
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68509429
109Lysine degradation_Homo sapiens_hsa003100.67978507
110Gap junction_Homo sapiens_hsa045400.67852505
111Melanoma_Homo sapiens_hsa052180.67147946
112FoxO signaling pathway_Homo sapiens_hsa040680.66731391
113Basal cell carcinoma_Homo sapiens_hsa052170.65561635
114Dorso-ventral axis formation_Homo sapiens_hsa043200.64435653
115Hematopoietic cell lineage_Homo sapiens_hsa046400.64316130
116Galactose metabolism_Homo sapiens_hsa000520.63815515
117Antigen processing and presentation_Homo sapiens_hsa046120.63806865
118Influenza A_Homo sapiens_hsa051640.63524248
119Endocytosis_Homo sapiens_hsa041440.62650497
120Nitrogen metabolism_Homo sapiens_hsa009100.62153296
121Sulfur relay system_Homo sapiens_hsa041220.62049991
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61223685
123Viral carcinogenesis_Homo sapiens_hsa052030.59720009
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59377562
125Complement and coagulation cascades_Homo sapiens_hsa046100.58871309
126Inositol phosphate metabolism_Homo sapiens_hsa005620.56003766
127Tight junction_Homo sapiens_hsa045300.55709107
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53685543
129Wnt signaling pathway_Homo sapiens_hsa043100.52403321
130Thyroid cancer_Homo sapiens_hsa052160.50981570

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