NABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.07184422
2chaperone-mediated protein transport (GO:0072321)5.19033399
3formation of translation preinitiation complex (GO:0001731)5.09004701
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62051588
5folic acid-containing compound biosynthetic process (GO:0009396)4.52631101
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40955322
7ATP synthesis coupled proton transport (GO:0015986)4.40955322
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.37114616
9regulation of mitochondrial translation (GO:0070129)4.08623223
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.03004430
11ribosomal large subunit biogenesis (GO:0042273)4.00629335
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.00011163
13DNA unwinding involved in DNA replication (GO:0006268)3.94614508
14peptidyl-arginine omega-N-methylation (GO:0035247)3.92275400
15DNA strand elongation involved in DNA replication (GO:0006271)3.89599312
16DNA replication checkpoint (GO:0000076)3.83586599
17protein complex biogenesis (GO:0070271)3.82457751
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80588925
19pteridine-containing compound biosynthetic process (GO:0042559)3.75322218
20protein localization to endoplasmic reticulum (GO:0070972)3.74823849
21cullin deneddylation (GO:0010388)3.74706806
22mitochondrial respiratory chain complex assembly (GO:0033108)3.72408452
23cellular component biogenesis (GO:0044085)3.71082227
24protein deneddylation (GO:0000338)3.70448038
25pentose-phosphate shunt (GO:0006098)3.69034027
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67991396
27respiratory electron transport chain (GO:0022904)3.66845592
28electron transport chain (GO:0022900)3.61766605
29DNA strand elongation (GO:0022616)3.60631468
30regulation of protein heterodimerization activity (GO:0043497)3.60413126
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.60041958
32NADH dehydrogenase complex assembly (GO:0010257)3.60041958
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60041958
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57029728
35telomere maintenance via semi-conservative replication (GO:0032201)3.53371857
36L-serine metabolic process (GO:0006563)3.52784033
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.49962368
38termination of RNA polymerase III transcription (GO:0006386)3.49962368
39establishment of integrated proviral latency (GO:0075713)3.45186842
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44719287
41protein targeting to mitochondrion (GO:0006626)3.44422160
42regulation of translational fidelity (GO:0006450)3.41173397
43proline biosynthetic process (GO:0006561)3.39968382
44NADPH regeneration (GO:0006740)3.38430932
45translational elongation (GO:0006414)3.38062418
46proteasome assembly (GO:0043248)3.37642075
47Golgi transport vesicle coating (GO:0048200)3.36854696
48COPI coating of Golgi vesicle (GO:0048205)3.36854696
49oxidative phosphorylation (GO:0006119)3.36659388
50IMP biosynthetic process (GO:0006188)3.36450457
51ribosomal small subunit assembly (GO:0000028)3.35810626
52histone arginine methylation (GO:0034969)3.34852100
53viral transcription (GO:0019083)3.33018927
54establishment of protein localization to mitochondrion (GO:0072655)3.32469836
55rRNA modification (GO:0000154)3.30783978
56ribosome biogenesis (GO:0042254)3.29683739
57nucleobase biosynthetic process (GO:0046112)3.29313879
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.27578240
59rRNA processing (GO:0006364)3.27258947
60amino acid salvage (GO:0043102)3.25771801
61L-methionine salvage (GO:0071267)3.25771801
62L-methionine biosynthetic process (GO:0071265)3.25771801
63protein complex disassembly (GO:0043241)3.24874844
64oxaloacetate metabolic process (GO:0006107)3.21301037
65translational termination (GO:0006415)3.20777639
66negative regulation of ligase activity (GO:0051352)3.19649166
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19649166
68spliceosomal snRNP assembly (GO:0000387)3.19596661
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19075222
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19075222
71pyrimidine nucleotide catabolic process (GO:0006244)3.18437316
72protein localization to mitochondrion (GO:0070585)3.16433688
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15392350
74pseudouridine synthesis (GO:0001522)3.15228591
75serine family amino acid biosynthetic process (GO:0009070)3.14796401
76translational initiation (GO:0006413)3.14363160
77macromolecular complex disassembly (GO:0032984)3.14310332
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14036159
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.13616124
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13512777
81rRNA metabolic process (GO:0016072)3.12761493
82peptidyl-arginine methylation (GO:0018216)3.10641998
83peptidyl-arginine N-methylation (GO:0035246)3.10641998
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10051726
85sequestering of actin monomers (GO:0042989)3.09755541
86maturation of SSU-rRNA (GO:0030490)3.07193932
87DNA replication initiation (GO:0006270)3.05749450
88CTP metabolic process (GO:0046036)3.04687402
89CTP biosynthetic process (GO:0006241)3.04687402
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04203132
91tetrahydrofolate metabolic process (GO:0046653)3.02651576
92respiratory chain complex IV assembly (GO:0008535)3.01639981
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.01062866
94nucleobase-containing small molecule interconversion (GO:0015949)2.99752345
95GTP biosynthetic process (GO:0006183)2.99527744
96maternal placenta development (GO:0001893)2.98615423
97IMP metabolic process (GO:0046040)2.98370425
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97883678
99guanosine-containing compound biosynthetic process (GO:1901070)2.96603680
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96495328
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96495328
102UTP biosynthetic process (GO:0006228)2.94906053
103purine nucleobase biosynthetic process (GO:0009113)2.93707520
104chromatin remodeling at centromere (GO:0031055)2.92973719
105transcription from mitochondrial promoter (GO:0006390)2.92288606
106protein insertion into membrane (GO:0051205)2.91217818
107GDP-mannose metabolic process (GO:0019673)2.90736170
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90199787
109T cell apoptotic process (GO:0070231)2.89252424
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89140951
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89140951
112signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89140951
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88550262
114transcription-coupled nucleotide-excision repair (GO:0006283)2.88270753
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87643585
116protein neddylation (GO:0045116)2.86349653
117behavioral response to nicotine (GO:0035095)2.85812562
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85085189
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.84473386
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84473386
121positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.83991528
122cytochrome complex assembly (GO:0017004)2.83500492
123ribonucleoprotein complex biogenesis (GO:0022613)2.83228617
124ribosomal small subunit biogenesis (GO:0042274)2.81004011
125purine nucleotide salvage (GO:0032261)2.80256237
126positive regulation of ligase activity (GO:0051351)2.79904781
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.79528557
128purine-containing compound salvage (GO:0043101)2.79123034
129pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.78917066
130protein targeting to membrane (GO:0006612)2.77437203
131nucleotide salvage (GO:0043173)2.76922627
132regulation of cellular amino acid metabolic process (GO:0006521)2.76176993
133metallo-sulfur cluster assembly (GO:0031163)2.76018087
134iron-sulfur cluster assembly (GO:0016226)2.76018087
135cotranslational protein targeting to membrane (GO:0006613)2.75949967
136protein targeting to ER (GO:0045047)2.75708569
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.75700069
138pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75691744
139regulation of translational termination (GO:0006449)2.75187435
140base-excision repair, AP site formation (GO:0006285)2.74808065
141heme biosynthetic process (GO:0006783)2.74684525
142telomere maintenance via recombination (GO:0000722)2.74089941
143CENP-A containing nucleosome assembly (GO:0034080)2.73011811
144mitotic nuclear envelope disassembly (GO:0007077)2.72682978
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72536356
146ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72437489
147tricarboxylic acid cycle (GO:0006099)2.72290680
148dosage compensation (GO:0007549)2.71637325
149peptidyl-histidine modification (GO:0018202)2.71312496
150mitochondrial transport (GO:0006839)2.71195928
151protein-cofactor linkage (GO:0018065)2.70178586
152nucleoside salvage (GO:0043174)2.69817969
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69735986
154negative regulation of RNA splicing (GO:0033119)2.69657071
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69429068
156purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69295408
157establishment of viral latency (GO:0019043)2.69261281
158purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.68634015
159viral life cycle (GO:0019058)2.68608912
160translation (GO:0006412)2.67265666
161pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.64982133
162protein localization to kinetochore (GO:0034501)2.64626879
163cellular protein complex disassembly (GO:0043624)2.63914429
164positive regulation of cell cycle arrest (GO:0071158)2.62366003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.54405923
2E2F7_22180533_ChIP-Seq_HELA_Human3.46080339
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.38692576
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05043267
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92395072
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62192598
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48220019
8MYC_22102868_ChIP-Seq_BL_Human2.46381857
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.45308501
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.38305159
11XRN2_22483619_ChIP-Seq_HELA_Human2.33040148
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32696297
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29246149
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26967777
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18834990
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15174770
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14387063
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10089035
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05398286
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97860177
21VDR_21846776_ChIP-Seq_THP-1_Human1.92518981
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91866929
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89231007
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.87602429
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86600349
26GABP_19822575_ChIP-Seq_HepG2_Human1.84781139
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84741886
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81544570
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79418906
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75453024
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74364011
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65825096
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62978908
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61609305
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60836816
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60155753
37DCP1A_22483619_ChIP-Seq_HELA_Human1.57965563
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56922903
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56010323
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55974633
41CIITA_25753668_ChIP-Seq_RAJI_Human1.54690964
42ELK1_19687146_ChIP-ChIP_HELA_Human1.52647171
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.52000919
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50813510
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.50318243
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49075713
47VDR_23849224_ChIP-Seq_CD4+_Human1.47814246
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47573458
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47363156
50LXR_22292898_ChIP-Seq_THP-1_Human1.47022786
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45648709
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.44724130
53FOXP3_21729870_ChIP-Seq_TREG_Human1.44675822
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42689942
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42009856
56MYC_18940864_ChIP-ChIP_HL60_Human1.41594486
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37462530
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.36572223
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35588660
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34776343
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34707173
62TTF2_22483619_ChIP-Seq_HELA_Human1.33872397
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33242519
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32620046
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31932452
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.31800392
67ZNF263_19887448_ChIP-Seq_K562_Human1.28774262
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28767494
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28175740
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26698203
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26566602
72KDM5A_27292631_Chip-Seq_BREAST_Human1.25019820
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23467435
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23209977
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23021445
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.20337901
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18793301
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17609908
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17275821
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17105665
81TFEB_21752829_ChIP-Seq_HELA_Human1.15999058
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15901184
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15299703
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15124742
85BCL6_27268052_Chip-Seq_Bcells_Human1.14744559
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12610915
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12393620
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12118290
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.11360268
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10207243
91P68_20966046_ChIP-Seq_HELA_Human1.10088847
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.08623825
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08558387
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07947095
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.06957380
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06032541
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05422066
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03728651
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03685952
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03420924
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03218636
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03046873
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02283069
104RACK7_27058665_Chip-Seq_MCF-7_Human1.01409178
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01338861
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00288149
107MAF_26560356_Chip-Seq_TH1_Human1.00190075
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99561512
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98724457
110UTX_26944678_Chip-Seq_JUKART_Human0.98723046
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98616429
112MAF_26560356_Chip-Seq_TH2_Human0.97828476
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96871144
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96723476
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96550348
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96387620
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96122417
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95674986
119AR_21909140_ChIP-Seq_LNCAP_Human0.93812855
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89652913
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89453189
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89303132
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.87973193
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.87387277
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87127617
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86617241
127IRF1_19129219_ChIP-ChIP_H3396_Human0.79872428
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78783577
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76396726
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75312738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.83622649
2MP0004957_abnormal_blastocyst_morpholog3.39589696
3MP0010030_abnormal_orbit_morphology3.36771012
4MP0009840_abnormal_foam_cell3.26831568
5MP0003693_abnormal_embryo_hatching3.25025460
6MP0009379_abnormal_foot_pigmentation3.13474420
7MP0006292_abnormal_olfactory_placode3.09265615
8MP0002653_abnormal_ependyma_morphology3.00166304
9MP0005083_abnormal_biliary_tract2.85481590
10MP0003077_abnormal_cell_cycle2.78199237
11MP0002234_abnormal_pharynx_morphology2.67728913
12MP0002163_abnormal_gland_morphology2.35471461
13MP0003111_abnormal_nucleus_morphology2.22340847
14MP0003705_abnormal_hypodermis_morpholog2.19098893
15MP0001730_embryonic_growth_arrest2.14324859
16MP0003186_abnormal_redox_activity2.08502445
17MP0003656_abnormal_erythrocyte_physiolo2.05472059
18MP0002396_abnormal_hematopoietic_system2.04251504
19MP0008789_abnormal_olfactory_epithelium2.03654909
20MP0005365_abnormal_bile_salt2.02718676
21MP0006036_abnormal_mitochondrial_physio1.98608480
22MP0001529_abnormal_vocalization1.97325664
23MP0010094_abnormal_chromosome_stability1.85098981
24MP0002160_abnormal_reproductive_system1.81722098
25MP0005499_abnormal_olfactory_system1.80431496
26MP0005394_taste/olfaction_phenotype1.80431496
27MP0004133_heterotaxia1.78019707
28MP0008932_abnormal_embryonic_tissue1.78014066
29MP0004233_abnormal_muscle_weight1.74593572
30MP0008007_abnormal_cellular_replicative1.72796907
31MP0002269_muscular_atrophy1.67872924
32MP0000350_abnormal_cell_proliferation1.65998361
33MP0002139_abnormal_hepatobiliary_system1.63809873
34MP0002938_white_spotting1.62086612
35MP0002089_abnormal_postnatal_growth/wei1.59265357
36MP0000049_abnormal_middle_ear1.58724200
37MP0001188_hyperpigmentation1.56095347
38MP0003786_premature_aging1.55951794
39MP0000358_abnormal_cell_content/1.53967828
40MP0009333_abnormal_splenocyte_physiolog1.52297236
41MP0004858_abnormal_nervous_system1.50492494
42MP0002080_prenatal_lethality1.47422553
43MP0001727_abnormal_embryo_implantation1.46912874
44MP0005379_endocrine/exocrine_gland_phen1.46805754
45MP0005360_urolithiasis1.45204682
46MP0010352_gastrointestinal_tract_polyps1.45075059
47MP0003136_yellow_coat_color1.44373942
48MP0005085_abnormal_gallbladder_physiolo1.44247938
49MP0005266_abnormal_metabolism1.43043332
50MP0001346_abnormal_lacrimal_gland1.42628732
51MP0003315_abnormal_perineum_morphology1.42610801
52MP0001697_abnormal_embryo_size1.42507509
53MP0003221_abnormal_cardiomyocyte_apopto1.42370191
54MP0000858_altered_metastatic_potential1.39223743
55MP0003880_abnormal_central_pattern1.38942503
56MP0002019_abnormal_tumor_incidence1.38223272
57MP0000313_abnormal_cell_death1.33528370
58MP0001919_abnormal_reproductive_system1.32739057
59MP0006035_abnormal_mitochondrial_morpho1.32493367
60MP0006276_abnormal_autonomic_nervous1.32324247
61MP0003123_paternal_imprinting1.30114366
62MP0009053_abnormal_anal_canal1.29406361
63MP0000685_abnormal_immune_system1.28080377
64MP0000490_abnormal_crypts_of1.28060119
65MP0003718_maternal_effect1.26601306
66MP0006072_abnormal_retinal_apoptosis1.24964884
67MP0001905_abnormal_dopamine_level1.24898247
68MP0003984_embryonic_growth_retardation1.23095302
69MP0005319_abnormal_enzyme/_coenzyme1.22774097
70MP0005389_reproductive_system_phenotype1.22529279
71MP0000778_abnormal_nervous_system1.22278344
72MP0002102_abnormal_ear_morphology1.21975048
73MP0005380_embryogenesis_phenotype1.21511370
74MP0001672_abnormal_embryogenesis/_devel1.21511370
75MP0009672_abnormal_birth_weight1.21073661
76MP0000750_abnormal_muscle_regeneration1.20684537
77MP0000631_abnormal_neuroendocrine_gland1.20499620
78MP0008058_abnormal_DNA_repair1.20039810
79MP0002132_abnormal_respiratory_system1.18102177
80MP0002088_abnormal_embryonic_growth/wei1.17974195
81MP0004142_abnormal_muscle_tone1.17951783
82MP0003646_muscle_fatigue1.17600480
83MP0002210_abnormal_sex_determination1.17047241
84MP0003121_genomic_imprinting1.16995381
85MP0001348_abnormal_lacrimal_gland1.16798581
86MP0001545_abnormal_hematopoietic_system1.14943578
87MP0005397_hematopoietic_system_phenotyp1.14943578
88MP0002638_abnormal_pupillary_reflex1.14521984
89MP0005584_abnormal_enzyme/coenzyme_acti1.13658036
90MP0008872_abnormal_physiological_respon1.13045542
91MP0003119_abnormal_digestive_system1.12949659
92MP0002736_abnormal_nociception_after1.12661611
93MP0005332_abnormal_amino_acid1.09515469
94MP0000598_abnormal_liver_morphology1.06909607
95MP0001853_heart_inflammation1.06159943
96MP0000372_irregular_coat_pigmentation1.04796325
97MP0002398_abnormal_bone_marrow1.04282284
98MP0002184_abnormal_innervation1.03385835
99MP0005423_abnormal_somatic_nervous1.03021503
100MP0002722_abnormal_immune_system1.02300572
101MP0001968_abnormal_touch/_nociception1.02066456
102MP0002085_abnormal_embryonic_tissue1.01908763
103MP0000689_abnormal_spleen_morphology1.01871834
104MP0003283_abnormal_digestive_organ1.00174254
105MP0000678_abnormal_parathyroid_gland0.99721311
106MP0000955_abnormal_spinal_cord0.99360259
107MP0003942_abnormal_urinary_system0.99220652
108MP0002084_abnormal_developmental_patter0.98382798
109MP0004197_abnormal_fetal_growth/weight/0.95153118
110MP0001293_anophthalmia0.94734120
111MP0009046_muscle_twitch0.94134273
112MP0005023_abnormal_wound_healing0.94069613
113MP0000749_muscle_degeneration0.93934498
114MP0000747_muscle_weakness0.92386837
115MP0004145_abnormal_muscle_electrophysio0.92317853
116MP0004147_increased_porphyrin_level0.92316056
117MP0001873_stomach_inflammation0.91885303
118MP0003763_abnormal_thymus_physiology0.91143220
119MP0008875_abnormal_xenobiotic_pharmacok0.90774288
120MP0000703_abnormal_thymus_morphology0.90621381
121MP0001145_abnormal_male_reproductive0.90500916
122MP0003861_abnormal_nervous_system0.90058302
123MP0008770_decreased_survivor_rate0.89864234
124MP0002970_abnormal_white_adipose0.88502859
125MP0002822_catalepsy0.88408727
126MP0000609_abnormal_liver_physiology0.88060290
127MP0001929_abnormal_gametogenesis0.87989172
128MP0001849_ear_inflammation0.87612357
129MP0002429_abnormal_blood_cell0.87463756
130MP0003567_abnormal_fetal_cardiomyocyte0.86914974
131MP0002752_abnormal_somatic_nervous0.86638886
132MP0010329_abnormal_lipoprotein_level0.85514726
133MP0003698_abnormal_male_reproductive0.85307027
134MP0003122_maternal_imprinting0.85191293
135MP0002249_abnormal_larynx_morphology0.84476740
136MP0002272_abnormal_nervous_system0.84105630
137MP0000566_synostosis0.83494492
138MP0003183_abnormal_peptide_metabolism0.83471872
139MP0002086_abnormal_extraembryonic_tissu0.83021495
140MP0003755_abnormal_palate_morphology0.82474890
141MP0001666_abnormal_nutrient_absorption0.81920779
142MP0003436_decreased_susceptibility_to0.81599685
143MP0000653_abnormal_sex_gland0.81579389
144MP0003172_abnormal_lysosome_physiology0.81091613
145MP0003937_abnormal_limbs/digits/tail_de0.81076706
146MP0005220_abnormal_exocrine_pancreas0.80879986
147MP0002177_abnormal_outer_ear0.78808067
148MP0005330_cardiomyopathy0.78666950
149MP0002733_abnormal_thermal_nociception0.77520453
150MP0005551_abnormal_eye_electrophysiolog0.76792351
151MP0000537_abnormal_urethra_morphology0.76785183
152MP0002697_abnormal_eye_size0.75585705
153MP0003938_abnormal_ear_development0.75482432
154MP0009745_abnormal_behavioral_response0.75405204
155MP0009250_abnormal_appendicular_skeleto0.74335065
156MP0000759_abnormal_skeletal_muscle0.74274517
157MP0002557_abnormal_social/conspecific_i0.73992196
158MP0005075_abnormal_melanosome_morpholog0.72722050
159MP0008961_abnormal_basal_metabolism0.72502122
160MP0004811_abnormal_neuron_physiology0.71595985
161MP0001286_abnormal_eye_development0.71497033
162MP0002152_abnormal_brain_morphology0.71109606
163MP0005076_abnormal_cell_differentiation0.71049098
164MP0006082_CNS_inflammation0.70380443
165MP0004859_abnormal_synaptic_plasticity0.69832896
166MP0002882_abnormal_neuron_morphology0.69775457
167MP0002233_abnormal_nose_morphology0.69585056
168MP0003385_abnormal_body_wall0.69143735
169MP0003191_abnormal_cellular_cholesterol0.68314221
170MP0005384_cellular_phenotype0.67904821

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)3.87191948
2Multiple enchondromatosis (HP:0005701)3.75546403
3Abnormality of the anterior horn cell (HP:0006802)3.72638942
4Degeneration of anterior horn cells (HP:0002398)3.72638942
5Progressive macrocephaly (HP:0004481)3.60985617
6Increased hepatocellular lipid droplets (HP:0006565)3.58521622
7Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45184156
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45184156
9Abnormality of glycolysis (HP:0004366)3.37483004
10Increased serum pyruvate (HP:0003542)3.37483004
11Oral leukoplakia (HP:0002745)3.35917350
12Renal Fanconi syndrome (HP:0001994)3.33616242
13Lipid accumulation in hepatocytes (HP:0006561)3.32841048
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.24142473
15Cerebral edema (HP:0002181)3.19086878
16Ragged-red muscle fibers (HP:0003200)3.07797721
17Abnormal gallbladder physiology (HP:0012438)3.05863027
18Cholecystitis (HP:0001082)3.05863027
19Atrophy/Degeneration involving motor neurons (HP:0007373)3.02086573
20Birth length less than 3rd percentile (HP:0003561)3.01986350
21Hepatocellular necrosis (HP:0001404)2.99313973
22Cholelithiasis (HP:0001081)2.97805444
23Abnormal neuron morphology (HP:0012757)2.95194817
24Abnormality of the motor neurons (HP:0002450)2.95194817
25Hepatic necrosis (HP:0002605)2.90795596
26Macrocytic anemia (HP:0001972)2.89865064
27Rhabdomyolysis (HP:0003201)2.83208188
28Microretrognathia (HP:0000308)2.81630956
29Hypobetalipoproteinemia (HP:0003563)2.76389283
30Myoglobinuria (HP:0002913)2.74134443
31Emotional lability (HP:0000712)2.72276821
32Trismus (HP:0000211)2.70336968
33Abnormality of the lower motor neuron (HP:0002366)2.69183476
34Abnormal gallbladder morphology (HP:0012437)2.62774220
35Abnormality of cells of the erythroid lineage (HP:0012130)2.60266947
36Abnormal number of erythroid precursors (HP:0012131)2.59097647
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58313460
38Retinal dysplasia (HP:0007973)2.56449161
39Late onset (HP:0003584)2.54600661
40Microvesicular hepatic steatosis (HP:0001414)2.53324440
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.51352663
42Adenoma sebaceum (HP:0009720)2.50363407
43Angiofibromas (HP:0010615)2.50363407
443-Methylglutaconic aciduria (HP:0003535)2.46612200
45Aplastic anemia (HP:0001915)2.46558008
46Abnormality of midbrain morphology (HP:0002418)2.37400274
47Molar tooth sign on MRI (HP:0002419)2.37400274
48Reticulocytosis (HP:0001923)2.36963486
49Hyperammonemia (HP:0001987)2.36555911
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.35623264
51Increased serum lactate (HP:0002151)2.34034134
52Abnormal mitochondria in muscle tissue (HP:0008316)2.33854689
53Spastic diplegia (HP:0001264)2.30130012
54Absent thumb (HP:0009777)2.28349653
55Opisthotonus (HP:0002179)2.27685868
56Progressive muscle weakness (HP:0003323)2.26731538
57Testicular atrophy (HP:0000029)2.26592297
58CNS demyelination (HP:0007305)2.25517052
59Ependymoma (HP:0002888)2.25142671
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21789145
61Concave nail (HP:0001598)2.20703710
62Leukodystrophy (HP:0002415)2.20064382
63Neuroendocrine neoplasm (HP:0100634)2.18411821
64Horseshoe kidney (HP:0000085)2.18392491
65Exertional dyspnea (HP:0002875)2.17140214
66Broad distal phalanx of finger (HP:0009836)2.17057792
67Delayed CNS myelination (HP:0002188)2.16954665
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14364981
69Abnormality of alanine metabolism (HP:0010916)2.14364981
70Hyperalaninemia (HP:0003348)2.14364981
71Optic disc pallor (HP:0000543)2.14091776
72Hyperbilirubinemia (HP:0002904)2.14086382
73Vertebral compression fractures (HP:0002953)2.13157333
74Mesangial abnormality (HP:0001966)2.12331464
75Abnormality of reticulocytes (HP:0004312)2.11877360
76Respiratory difficulties (HP:0002880)2.10636103
77Hypercortisolism (HP:0001578)2.10515922
78Lethargy (HP:0001254)2.09648490
79Selective tooth agenesis (HP:0001592)2.08197509
80Progressive microcephaly (HP:0000253)2.05428144
81Myokymia (HP:0002411)2.05082443
82Pallor (HP:0000980)2.04690481
83Abnormality of the gallbladder (HP:0005264)2.03593337
84Tongue fasciculations (HP:0001308)2.03527257
85Poor suck (HP:0002033)2.03160045
86Neoplasm of the peripheral nervous system (HP:0100007)2.02934295
87Acute encephalopathy (HP:0006846)2.02588775
88Neonatal onset (HP:0003623)2.01485313
89Type I transferrin isoform profile (HP:0003642)2.01173095
90IgM deficiency (HP:0002850)1.99226458
91CNS hypomyelination (HP:0003429)1.99204505
92Lactic acidosis (HP:0003128)1.98263837
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98045232
94Increased serum ferritin (HP:0003281)1.97276477
95Muscle fibrillation (HP:0010546)1.96483750
96Hand muscle atrophy (HP:0009130)1.96268691
97Hyperacusis (HP:0010780)1.95874170
98Hypoplasia of the pons (HP:0012110)1.91121358
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89474190
100Optic nerve coloboma (HP:0000588)1.88521670
101Aplasia/Hypoplasia of the patella (HP:0006498)1.87682366
102Chromsome breakage (HP:0040012)1.87113333
103Mitochondrial inheritance (HP:0001427)1.86580200
104Abnormality of fatty-acid metabolism (HP:0004359)1.86311383
105Broad alveolar ridges (HP:0000187)1.86147978
106Type II lissencephaly (HP:0007260)1.85933383
107Respiratory failure (HP:0002878)1.85610099
108Pheochromocytoma (HP:0002666)1.85608917
109Abnormal protein N-linked glycosylation (HP:0012347)1.85490644
110Abnormal protein glycosylation (HP:0012346)1.85490644
111Abnormal glycosylation (HP:0012345)1.85490644
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85490644
113Gout (HP:0001997)1.85358746
114Increased CSF lactate (HP:0002490)1.85207873
115Abnormality of pyrimidine metabolism (HP:0004353)1.85154403
116Pancytopenia (HP:0001876)1.84697173
117X-linked dominant inheritance (HP:0001423)1.84652721
118Sclerocornea (HP:0000647)1.83627532
119Delusions (HP:0000746)1.83466480
120Muscle fiber atrophy (HP:0100295)1.83199164
121Abnormal number of incisors (HP:0011064)1.82950219
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82159930
123Postnatal microcephaly (HP:0005484)1.81778434
124Colon cancer (HP:0003003)1.81409971
125Meckel diverticulum (HP:0002245)1.80964135
126Patellar aplasia (HP:0006443)1.80337590
127Increased muscle lipid content (HP:0009058)1.79010284
128Preauricular skin tag (HP:0000384)1.78961235
129Elevated erythrocyte sedimentation rate (HP:0003565)1.78949037
130Acute necrotizing encephalopathy (HP:0006965)1.74839089
131Abnormality of the ileum (HP:0001549)1.74633201
132Thrombocytosis (HP:0001894)1.73908417
133Upper limb amyotrophy (HP:0009129)1.73620710
134Distal upper limb amyotrophy (HP:0007149)1.73620710
135Generalized aminoaciduria (HP:0002909)1.73563633
136Increased nuchal translucency (HP:0010880)1.72483380
137Abnormality of renal resorption (HP:0011038)1.72306363
138Pachygyria (HP:0001302)1.72013548
139Abnormal cartilage morphology (HP:0002763)1.71372125
140Abnormality of the Achilles tendon (HP:0005109)1.69948944
141Palpitations (HP:0001962)1.69657592
142Abnormality of the pons (HP:0007361)1.68455301
143Abnormality of the alveolar ridges (HP:0006477)1.68269076
144Hyperthyroidism (HP:0000836)1.68242500
145Ketosis (HP:0001946)1.68195510
146Exercise intolerance (HP:0003546)1.67916485
147Brushfield spots (HP:0001088)1.67354398
148Reticulocytopenia (HP:0001896)1.67279802
149Rough bone trabeculation (HP:0100670)1.67131516
150Growth hormone excess (HP:0000845)1.66005806
151Unsteady gait (HP:0002317)1.64473669
152Renal duplication (HP:0000075)1.63706468
153Increased intramyocellular lipid droplets (HP:0012240)1.63585746
154Achilles tendon contracture (HP:0001771)1.63210408
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.63164482
156Reduced antithrombin III activity (HP:0001976)1.61979602
157Cortical dysplasia (HP:0002539)1.61778769
158Hyperglycinemia (HP:0002154)1.58951760
159Methylmalonic aciduria (HP:0012120)1.58217526
160Cleft eyelid (HP:0000625)1.58121624
161Squamous cell carcinoma (HP:0002860)1.57308377
162Abnormality of urine glucose concentration (HP:0011016)1.57228649
163Glycosuria (HP:0003076)1.57228649
164Cerebellar hypoplasia (HP:0001321)1.57137344
165Facial cleft (HP:0002006)1.57105027
166Pendular nystagmus (HP:0012043)1.53192732
167Triphalangeal thumb (HP:0001199)1.52068487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.74268294
2VRK24.08912116
3BUB13.77258228
4NEK13.07425344
5TESK12.92363258
6ERN12.85957878
7TRIB32.85836824
8EEF2K2.65265412
9ZAK2.55894384
10PIM22.55177492
11BCKDK2.45557088
12SRPK12.39308859
13MAPKAPK32.16137316
14CDK192.05717174
15KDR2.05364429
16LIMK12.04329308
17MAP3K102.03463278
18SCYL22.01394035
19PKN21.99238451
20MAP3K111.96985178
21EIF2AK11.80876519
22CDC71.77436705
23PAK41.66582242
24DAPK11.64955164
25ILK1.63879546
26LRRK21.59996226
27TSSK61.59165830
28NME21.44626329
29GRK61.43933645
30IRAK31.42530726
31MAP2K71.38949287
32TRIM281.38369481
33BRSK11.36197462
34PBK1.35458435
35PRKD31.33442005
36CHEK21.32644051
37PASK1.27027840
38MAP4K11.25466590
39MAP3K91.18726371
40TAOK11.16611467
41AURKA1.12745391
42RPS6KB21.12310978
43FLT31.12247302
44CDK71.09819863
45WEE11.09648534
46DAPK31.09530036
47PNCK1.08541824
48CCNB11.08414913
49RPS6KA41.07762321
50PLK41.07059965
51NEK21.03311889
52PLK31.03227063
53PDK21.02347859
54TAF11.01318199
55CSNK1G31.00762969
56STK101.00734089
57MAP2K30.95004043
58UHMK10.94476719
59MAP4K20.93915931
60ZAP700.91693814
61PAK10.90330916
62MAP3K80.87586762
63BMPR1B0.84678526
64PLK10.84372384
65TLK10.82299042
66SMG10.81731596
67MAP3K120.81143566
68NUAK10.80048162
69NME10.78888041
70BMX0.78541107
71WNK40.75938070
72TAOK20.75270533
73CDK90.75007157
74BTK0.73867823
75CDK80.72765168
76CDK40.72600897
77PRKCG0.72574149
78ICK0.72375363
79CSNK1A1L0.71714866
80CSNK1G20.71656726
81EPHA20.71263585
82ALK0.70420134
83MAP2K60.68331912
84PTK20.66339390
85MUSK0.66117716
86MAPK110.65495958
87CSF1R0.65349012
88RPS6KA50.65059952
89STK160.64515352
90BRAF0.64471757
91CDK11A0.62783550
92GRK10.61606598
93AURKB0.61265391
94CDK120.60789478
95LATS20.60391804
96PIK3CA0.59929957
97PHKG10.59562391
98PHKG20.59562391
99VRK10.57988955
100CDK140.56977572
101MARK10.56592717
102CDK180.55374493
103CSNK1G10.55239958
104AKT20.55103432
105TGFBR10.54687891
106ATR0.53913030
107CDK150.53515764
108DYRK1B0.53398007
109EIF2AK20.51447689
110SIK10.50685194
111CSNK1E0.50409281
112DYRK30.50125348
113PRKCI0.49521899
114MATK0.49415089
115CASK0.48225071
116MAP2K20.47477319
117* ATM0.47075679
118CAMK1D0.45253643
119DYRK20.44543791
120SIK30.44132692
121ARAF0.43385824
122CAMKK20.43173989
123BLK0.42762366
124TTK0.42761237
125CDK10.42378986
126MAPKAPK50.41883292
127EPHB20.40928059
128CAMK1G0.39962618
129ACVR1B0.39289443
130CAMKK10.37717018
131CDK20.37027094
132TBK10.36876887
133MINK10.36785471
134CSNK2A20.36696320
135EIF2AK30.36582914
136CSNK2A10.36289108
137RPS6KA10.35885457
138WNK30.35654194
139MAP3K40.34938688
140CHEK10.34591571
141MTOR0.34216408
142MAPKAPK20.33507526
143ABL20.31449623
144RAF10.30758646
145BRSK20.29691105

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.82099678
2Proteasome_Homo sapiens_hsa030503.50239894
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.32337403
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.00848750
5Mismatch repair_Homo sapiens_hsa034302.92785895
6Ribosome_Homo sapiens_hsa030102.83262438
7Biosynthesis of amino acids_Homo sapiens_hsa012302.70696909
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68151244
9Sulfur relay system_Homo sapiens_hsa041222.67915089
10Base excision repair_Homo sapiens_hsa034102.57495689
11Spliceosome_Homo sapiens_hsa030402.46466373
12Carbon metabolism_Homo sapiens_hsa012002.23299239
13One carbon pool by folate_Homo sapiens_hsa006702.14606658
14Folate biosynthesis_Homo sapiens_hsa007902.11252805
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03621678
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.00756884
17RNA transport_Homo sapiens_hsa030131.98790882
18RNA polymerase_Homo sapiens_hsa030201.92916217
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91169766
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86326516
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.78751049
22Pentose phosphate pathway_Homo sapiens_hsa000301.77523807
23Pyrimidine metabolism_Homo sapiens_hsa002401.75315506
24Fanconi anemia pathway_Homo sapiens_hsa034601.68825275
25Fructose and mannose metabolism_Homo sapiens_hsa000511.62744570
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62597157
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.61188527
28Cardiac muscle contraction_Homo sapiens_hsa042601.57374657
29Pyruvate metabolism_Homo sapiens_hsa006201.47755289
30Nucleotide excision repair_Homo sapiens_hsa034201.40969322
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40699286
32Galactose metabolism_Homo sapiens_hsa000521.40042514
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34993314
34Basal transcription factors_Homo sapiens_hsa030221.31915553
35Arginine biosynthesis_Homo sapiens_hsa002201.28609676
36Cell cycle_Homo sapiens_hsa041101.28500812
37Nitrogen metabolism_Homo sapiens_hsa009101.27167512
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21930037
39Parkinsons disease_Homo sapiens_hsa050121.20963359
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18832878
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18219586
42Non-homologous end-joining_Homo sapiens_hsa034501.13436092
43Thyroid cancer_Homo sapiens_hsa052161.11965129
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.11475938
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01994662
46Homologous recombination_Homo sapiens_hsa034400.95725885
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.92333080
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90163171
49mRNA surveillance pathway_Homo sapiens_hsa030150.89206481
50Bladder cancer_Homo sapiens_hsa052190.87246711
51RNA degradation_Homo sapiens_hsa030180.83407139
52Steroid biosynthesis_Homo sapiens_hsa001000.79827032
53Oxidative phosphorylation_Homo sapiens_hsa001900.78446298
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78257797
55Selenocompound metabolism_Homo sapiens_hsa004500.77773649
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75689641
57Vitamin B6 metabolism_Homo sapiens_hsa007500.74885100
58Phenylalanine metabolism_Homo sapiens_hsa003600.74077883
59Arginine and proline metabolism_Homo sapiens_hsa003300.72065013
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72052344
61Fatty acid degradation_Homo sapiens_hsa000710.71836458
62Glutathione metabolism_Homo sapiens_hsa004800.71500641
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.70929939
64Fatty acid metabolism_Homo sapiens_hsa012120.70670994
65Sulfur metabolism_Homo sapiens_hsa009200.68848301
66p53 signaling pathway_Homo sapiens_hsa041150.68480250
67Huntingtons disease_Homo sapiens_hsa050160.65645291
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65294317
69Shigellosis_Homo sapiens_hsa051310.64151161
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64126313
71Epstein-Barr virus infection_Homo sapiens_hsa051690.62077158
72Purine metabolism_Homo sapiens_hsa002300.61296184
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61123548
74Legionellosis_Homo sapiens_hsa051340.55893022
75Alcoholism_Homo sapiens_hsa050340.55842644
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54021790
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51795343
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51295766
79Propanoate metabolism_Homo sapiens_hsa006400.50346602
80Tryptophan metabolism_Homo sapiens_hsa003800.49822719
81Antigen processing and presentation_Homo sapiens_hsa046120.47178690
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45244758
83Nicotine addiction_Homo sapiens_hsa050330.45128141
84Peroxisome_Homo sapiens_hsa041460.44942411
85Phototransduction_Homo sapiens_hsa047440.44828824
86N-Glycan biosynthesis_Homo sapiens_hsa005100.43868033
87Butanoate metabolism_Homo sapiens_hsa006500.43557748
88Fat digestion and absorption_Homo sapiens_hsa049750.42945023
89Notch signaling pathway_Homo sapiens_hsa043300.42150030
90Vibrio cholerae infection_Homo sapiens_hsa051100.40630442
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39069148
92Basal cell carcinoma_Homo sapiens_hsa052170.38345416
93Starch and sucrose metabolism_Homo sapiens_hsa005000.38038221
94Oocyte meiosis_Homo sapiens_hsa041140.36188198
95Metabolic pathways_Homo sapiens_hsa011000.34571713
96Acute myeloid leukemia_Homo sapiens_hsa052210.34037125
97Caffeine metabolism_Homo sapiens_hsa002320.33553562
98Protein export_Homo sapiens_hsa030600.30163470
99Chronic myeloid leukemia_Homo sapiens_hsa052200.29729927
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29295774
101Hedgehog signaling pathway_Homo sapiens_hsa043400.28941062
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28450962
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28343274
104HTLV-I infection_Homo sapiens_hsa051660.27818143
105Colorectal cancer_Homo sapiens_hsa052100.27814940
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27320491
107Apoptosis_Homo sapiens_hsa042100.26996063
108Alzheimers disease_Homo sapiens_hsa050100.26930728
109Fatty acid elongation_Homo sapiens_hsa000620.26412230
110Tyrosine metabolism_Homo sapiens_hsa003500.25454456
111beta-Alanine metabolism_Homo sapiens_hsa004100.25422318
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25279944
113Collecting duct acid secretion_Homo sapiens_hsa049660.24807583
114Viral carcinogenesis_Homo sapiens_hsa052030.24757944
115Synaptic vesicle cycle_Homo sapiens_hsa047210.24581485
116HIF-1 signaling pathway_Homo sapiens_hsa040660.23862388
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23466666
118Non-small cell lung cancer_Homo sapiens_hsa052230.22961428
119Systemic lupus erythematosus_Homo sapiens_hsa053220.21937151
120Primary immunodeficiency_Homo sapiens_hsa053400.21889147
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.21762160
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21586772
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18805297
124Hippo signaling pathway_Homo sapiens_hsa043900.15628065
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10971516
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10763221

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