NACA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.95303288
2ribosomal small subunit assembly (GO:0000028)6.98829370
3viral transcription (GO:0019083)6.95922813
4ATP synthesis coupled proton transport (GO:0015986)6.88171190
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.88171190
6translational termination (GO:0006415)6.68518608
7maturation of SSU-rRNA (GO:0030490)6.59441505
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.55297156
9translational elongation (GO:0006414)5.75100836
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.72913322
11behavioral response to nicotine (GO:0035095)5.71500007
12cotranslational protein targeting to membrane (GO:0006613)5.63608247
13chaperone-mediated protein transport (GO:0072321)5.63135313
14protein targeting to ER (GO:0045047)5.59289284
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.39676482
16protein localization to endoplasmic reticulum (GO:0070972)5.22601085
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.16055657
18cellular protein complex disassembly (GO:0043624)5.11918618
19viral life cycle (GO:0019058)5.07118373
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.84589948
21DNA deamination (GO:0045006)4.77590991
22protein neddylation (GO:0045116)4.70934636
23respiratory electron transport chain (GO:0022904)4.66989314
24electron transport chain (GO:0022900)4.59318669
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54622730
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.54622730
27NADH dehydrogenase complex assembly (GO:0010257)4.54622730
28translational initiation (GO:0006413)4.54201970
29regulation of gene silencing by RNA (GO:0060966)4.42814260
30regulation of posttranscriptional gene silencing (GO:0060147)4.42814260
31regulation of gene silencing by miRNA (GO:0060964)4.42814260
32translation (GO:0006412)4.32533022
33protein complex biogenesis (GO:0070271)4.31929144
34protein complex disassembly (GO:0043241)4.31566708
35ribosomal large subunit biogenesis (GO:0042273)4.27743386
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.26050811
37ribonucleoprotein complex biogenesis (GO:0022613)4.21261528
38macromolecular complex disassembly (GO:0032984)4.14295716
39mitochondrial respiratory chain complex assembly (GO:0033108)4.09086856
40cellular component biogenesis (GO:0044085)4.04106656
41ATP biosynthetic process (GO:0006754)3.89603389
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82804478
43water-soluble vitamin biosynthetic process (GO:0042364)3.82310171
44negative regulation of gene silencing (GO:0060969)3.81452879
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.77330580
46histone H4-K12 acetylation (GO:0043983)3.71319867
47pseudouridine synthesis (GO:0001522)3.70291226
48protein targeting to membrane (GO:0006612)3.66521077
49DNA damage response, detection of DNA damage (GO:0042769)3.64139441
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62419518
51GTP biosynthetic process (GO:0006183)3.61274591
52ncRNA 3-end processing (GO:0043628)3.57362175
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.52314527
54intracellular protein transmembrane import (GO:0044743)3.51135836
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.38968511
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34157742
57rRNA processing (GO:0006364)3.33234759
58mRNA catabolic process (GO:0006402)3.31868720
59cullin deneddylation (GO:0010388)3.30777984
60hydrogen ion transmembrane transport (GO:1902600)3.28862940
61protein-cofactor linkage (GO:0018065)3.27749231
62rRNA metabolic process (GO:0016072)3.25799084
63UTP biosynthetic process (GO:0006228)3.19371210
64protein targeting to mitochondrion (GO:0006626)3.18395990
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15542421
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15542421
67protein deneddylation (GO:0000338)3.14713842
68proteasome assembly (GO:0043248)3.13373457
69response to pheromone (GO:0019236)3.12474862
70proton transport (GO:0015992)3.05308323
71RNA catabolic process (GO:0006401)3.02125214
72nucleoside triphosphate biosynthetic process (GO:0009142)3.00868126
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98253459
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97958246
75establishment of protein localization to mitochondrion (GO:0072655)2.97398405
76hydrogen transport (GO:0006818)2.96295026
77RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.96131200
78regulation of mitochondrial translation (GO:0070129)2.95515101
79ribosome biogenesis (GO:0042254)2.92927792
80heart trabecula morphogenesis (GO:0061384)2.92457148
81UTP metabolic process (GO:0046051)2.90722772
82peptidyl-histidine modification (GO:0018202)2.82369295
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.81234957
84termination of RNA polymerase III transcription (GO:0006386)2.81234957
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80914152
86protein localization to mitochondrion (GO:0070585)2.79365120
87pyrimidine nucleotide catabolic process (GO:0006244)2.79286686
88tRNA processing (GO:0008033)2.79246922
89cytidine deamination (GO:0009972)2.79169862
90cytidine metabolic process (GO:0046087)2.79169862
91cytidine catabolic process (GO:0006216)2.79169862
92respiratory chain complex IV assembly (GO:0008535)2.78511524
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.71485911
94autophagic vacuole fusion (GO:0000046)2.69216044
95regulation of mitotic spindle checkpoint (GO:1903504)2.68382757
96regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68382757
97pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67996283
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66432202
99mitochondrial transport (GO:0006839)2.65598827
100metallo-sulfur cluster assembly (GO:0031163)2.64701324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.31076233
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02824630
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75178757
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41187972
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.39364701
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31749439
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.28536203
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.22993109
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20234462
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.76621027
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47100362
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41207423
13VDR_22108803_ChIP-Seq_LS180_Human2.30813144
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26426137
15VDR_23849224_ChIP-Seq_CD4+_Human2.22734790
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18032163
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.16062103
18MYC_18940864_ChIP-ChIP_HL60_Human2.15062148
19EZH2_22144423_ChIP-Seq_EOC_Human2.09808787
20ZNF274_21170338_ChIP-Seq_K562_Hela2.09143720
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03715576
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01328925
23XRN2_22483619_ChIP-Seq_HELA_Human1.99651638
24TTF2_22483619_ChIP-Seq_HELA_Human1.83209844
25FOXP3_21729870_ChIP-Seq_TREG_Human1.83024290
26ELK1_19687146_ChIP-ChIP_HELA_Human1.79299264
27GABP_19822575_ChIP-Seq_HepG2_Human1.75462815
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75156102
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71144244
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.68843974
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65427698
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64425361
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62067147
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55646611
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53972312
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53372747
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53058928
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50444990
39IRF1_19129219_ChIP-ChIP_H3396_Human1.47360730
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.44782353
41DCP1A_22483619_ChIP-Seq_HELA_Human1.44298081
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37636712
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33101869
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.33072092
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32376540
46TP53_22573176_ChIP-Seq_HFKS_Human1.24397208
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23281918
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20762963
49TAF2_19829295_ChIP-Seq_ESCs_Human1.20725062
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19927234
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.18422050
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.17731047
53ERA_21632823_ChIP-Seq_H3396_Human1.16757100
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16616270
55IGF1R_20145208_ChIP-Seq_DFB_Human1.15263553
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15031766
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15000468
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13193651
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12877838
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12842971
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.11199394
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.10614855
63STAT1_20625510_ChIP-Seq_HELA_Human1.09799161
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08883599
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07898108
66AR_20517297_ChIP-Seq_VCAP_Human1.06875335
67BCL6_27268052_Chip-Seq_Bcells_Human1.05532606
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03792988
69NANOG_20526341_ChIP-Seq_ESCs_Human1.03684845
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.02514711
71NCOR_22424771_ChIP-Seq_293T_Human1.01910949
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00067518
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99567518
74JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98510467
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98425247
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98221669
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96111165
78* CTCF_20526341_ChIP-Seq_ESCs_Human0.94218830
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.94129092
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93574783
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92603894
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92205105
83EWS_26573619_Chip-Seq_HEK293_Human0.92143766
84KDM5A_27292631_Chip-Seq_BREAST_Human0.90045033
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88833928
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.88194907
87SA1_27219007_Chip-Seq_Bcells_Human0.88127256
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85800944
89RNF2_27304074_Chip-Seq_NSC_Mouse0.85549599
90E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85497026
91P53_21459846_ChIP-Seq_SAOS-2_Human0.85129857
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84854025
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84836318
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84819964
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.83670430
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83340975
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82577476
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81554901
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81367296
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80816420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.06880359
2MP0006292_abnormal_olfactory_placode4.29993256
3MP0001188_hyperpigmentation2.99684123
4MP0003567_abnormal_fetal_cardiomyocyte2.63931199
5MP0004885_abnormal_endolymph2.62103595
6MP0002163_abnormal_gland_morphology2.56435101
7MP0005671_abnormal_response_to2.37720972
8MP0004142_abnormal_muscle_tone2.14654006
9MP0008877_abnormal_DNA_methylation2.14514554
10MP0004145_abnormal_muscle_electrophysio2.12644804
11MP0003878_abnormal_ear_physiology2.04059023
12MP0005377_hearing/vestibular/ear_phenot2.04059023
13MP0005646_abnormal_pituitary_gland1.98347517
14MP0003787_abnormal_imprinting1.91897997
15MP0006072_abnormal_retinal_apoptosis1.86406751
16MP0002102_abnormal_ear_morphology1.83607494
17MP0000372_irregular_coat_pigmentation1.82937796
18MP0002138_abnormal_hepatobiliary_system1.79888255
19MP0001485_abnormal_pinna_reflex1.67711306
20MP0008875_abnormal_xenobiotic_pharmacok1.67339684
21MP0002638_abnormal_pupillary_reflex1.66360829
22MP0000049_abnormal_middle_ear1.65637524
23MP0002876_abnormal_thyroid_physiology1.58416224
24MP0005551_abnormal_eye_electrophysiolog1.54411177
25MP0008872_abnormal_physiological_respon1.50222441
26MP0005084_abnormal_gallbladder_morpholo1.49764191
27MP0003136_yellow_coat_color1.48492237
28MP0001968_abnormal_touch/_nociception1.48338394
29MP0003646_muscle_fatigue1.44821406
30MP0005379_endocrine/exocrine_gland_phen1.43759213
31MP0002837_dystrophic_cardiac_calcinosis1.41278824
32MP0004043_abnormal_pH_regulation1.40962136
33MP0004147_increased_porphyrin_level1.40344405
34MP0001293_anophthalmia1.39303096
35MP0001348_abnormal_lacrimal_gland1.37744157
36MP0008789_abnormal_olfactory_epithelium1.37543556
37MP0001529_abnormal_vocalization1.36775439
38MP0003786_premature_aging1.36117401
39MP0002653_abnormal_ependyma_morphology1.33109197
40MP0006276_abnormal_autonomic_nervous1.31342499
41MP0009745_abnormal_behavioral_response1.30700714
42MP0003123_paternal_imprinting1.30445764
43MP0000631_abnormal_neuroendocrine_gland1.28351708
44MP0006082_CNS_inflammation1.28104051
45MP0000685_abnormal_immune_system1.26324758
46MP0008058_abnormal_DNA_repair1.25512279
47MP0005389_reproductive_system_phenotype1.24434924
48MP0003186_abnormal_redox_activity1.24322690
49MP0001919_abnormal_reproductive_system1.24023500
50MP0009333_abnormal_splenocyte_physiolog1.22813828
51MP0004742_abnormal_vestibular_system1.22161788
52MP0002736_abnormal_nociception_after1.20096713
53MP0000750_abnormal_muscle_regeneration1.18826366
54MP0001905_abnormal_dopamine_level1.16923503
55MP0002160_abnormal_reproductive_system1.16758357
56MP0009046_muscle_twitch1.16387810
57MP0002272_abnormal_nervous_system1.12460886
58MP0003880_abnormal_central_pattern1.10985787
59MP0002938_white_spotting1.10080470
60MP0001502_abnormal_circadian_rhythm1.07096530
61MP0005195_abnormal_posterior_eye1.06993030
62MP0000026_abnormal_inner_ear1.06096773
63MP0002234_abnormal_pharynx_morphology1.04793620
64MP0002095_abnormal_skin_pigmentation1.01495521
65MP0001486_abnormal_startle_reflex1.01178381
66MP0006036_abnormal_mitochondrial_physio0.99002177
67MP0004019_abnormal_vitamin_homeostasis0.97918118
68MP0001984_abnormal_olfaction0.97756778
69MP0008995_early_reproductive_senescence0.96376522
70MP0002733_abnormal_thermal_nociception0.94986130
71MP0003938_abnormal_ear_development0.94692447
72MP0003693_abnormal_embryo_hatching0.94117979
73MP0004133_heterotaxia0.93455054
74MP0003121_genomic_imprinting0.92485701
75MP0005253_abnormal_eye_physiology0.92291896
76MP0002277_abnormal_respiratory_mucosa0.91121176
77MP0005187_abnormal_penis_morphology0.88639863
78MP0005645_abnormal_hypothalamus_physiol0.87934487
79MP0000647_abnormal_sebaceous_gland0.87869756
80MP0005499_abnormal_olfactory_system0.87022717
81MP0005394_taste/olfaction_phenotype0.87022717
82MP0001970_abnormal_pain_threshold0.84824406
83MP0002210_abnormal_sex_determination0.83683220
84MP0000566_synostosis0.82608226
85MP0001963_abnormal_hearing_physiology0.82351908
86MP0003011_delayed_dark_adaptation0.82117398
87MP0003122_maternal_imprinting0.78745613
88MP0003119_abnormal_digestive_system0.78217401
89MP0002752_abnormal_somatic_nervous0.77048506
90MP0001986_abnormal_taste_sensitivity0.75771607
91MP0002557_abnormal_social/conspecific_i0.75704085
92MP0009785_altered_susceptibility_to0.72243348
93MP0003806_abnormal_nucleotide_metabolis0.71947786
94MP0002184_abnormal_innervation0.70759457
95MP0002148_abnormal_hypersensitivity_rea0.69379177
96MP0002064_seizures0.69219155
97MP0000653_abnormal_sex_gland0.68981668
98MP0008775_abnormal_heart_ventricle0.68948092
99MP0001764_abnormal_homeostasis0.67367337
100MP0003936_abnormal_reproductive_system0.67224147

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.99242776
2Acute necrotizing encephalopathy (HP:0006965)4.98881102
3Abnormal mitochondria in muscle tissue (HP:0008316)4.59078508
4Reticulocytopenia (HP:0001896)4.42232453
5Mitochondrial inheritance (HP:0001427)4.37043866
6Acute encephalopathy (HP:0006846)4.36324304
7Progressive macrocephaly (HP:0004481)4.10186080
8Increased CSF lactate (HP:0002490)4.05181257
9Abnormality of cells of the erythroid lineage (HP:0012130)3.58343640
10Hepatocellular necrosis (HP:0001404)3.53215135
11Macrocytic anemia (HP:0001972)3.39430232
12Hepatic necrosis (HP:0002605)3.23621689
13Increased hepatocellular lipid droplets (HP:0006565)3.21617638
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16505274
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16505274
16Increased intramyocellular lipid droplets (HP:0012240)3.13731413
17Cerebral edema (HP:0002181)3.11942232
18Pallor (HP:0000980)3.10276719
19Congenital stationary night blindness (HP:0007642)3.01920396
20Abnormal number of erythroid precursors (HP:0012131)3.00658032
21Lipid accumulation in hepatocytes (HP:0006561)3.00434429
22Renal Fanconi syndrome (HP:0001994)2.91048001
23Increased serum lactate (HP:0002151)2.86949688
24Optic disc pallor (HP:0000543)2.82357446
25Molar tooth sign on MRI (HP:0002419)2.76745510
26Abnormality of midbrain morphology (HP:0002418)2.76745510
27Lactic acidosis (HP:0003128)2.65875129
28Increased muscle lipid content (HP:0009058)2.62505039
29Pendular nystagmus (HP:0012043)2.57967045
30Progressive microcephaly (HP:0000253)2.56913982
31Respiratory difficulties (HP:0002880)2.51150556
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47662348
33Type 2 muscle fiber atrophy (HP:0003554)2.46976499
34Absent thumb (HP:0009777)2.46788014
35Abnormal hemoglobin (HP:0011902)2.46527660
36Abnormal rod and cone electroretinograms (HP:0008323)2.44112106
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39680293
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39158357
39Exertional dyspnea (HP:0002875)2.38919053
40Pancreatic fibrosis (HP:0100732)2.35087040
41Abnormality of alanine metabolism (HP:0010916)2.30672977
42Hyperalaninemia (HP:0003348)2.30672977
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30672977
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28923745
45Hypoplasia of the radius (HP:0002984)2.28618333
46Aplasia/hypoplasia of the uterus (HP:0008684)2.28093065
47Stenosis of the external auditory canal (HP:0000402)2.27176763
48Muscle fiber atrophy (HP:0100295)2.26577006
49Pancreatic cysts (HP:0001737)2.25151515
50Severe visual impairment (HP:0001141)2.19097552
51Myokymia (HP:0002411)2.18919808
52Leukodystrophy (HP:0002415)2.17586963
53Respiratory failure (HP:0002878)2.17379748
54Exercise intolerance (HP:0003546)2.16183059
55Type II lissencephaly (HP:0007260)2.15739900
56Congenital, generalized hypertrichosis (HP:0004540)2.14973186
57Hyperglycinemia (HP:0002154)2.11224755
58Deep palmar crease (HP:0006191)2.10675278
59Horseshoe kidney (HP:0000085)2.09996841
60Nephronophthisis (HP:0000090)2.09841676
61Triphalangeal thumb (HP:0001199)2.09528581
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07108123
63Hypoplasia of the uterus (HP:0000013)2.02903660
64Symphalangism affecting the phalanges of the hand (HP:0009773)2.02412572
65True hermaphroditism (HP:0010459)2.00264243
66Lethargy (HP:0001254)1.99374406
67Concave nail (HP:0001598)1.96938305
68Submucous cleft hard palate (HP:0000176)1.96197353
69Aplasia/Hypoplasia of the spleen (HP:0010451)1.95856295
70Forearm undergrowth (HP:0009821)1.93318016
71Abolished electroretinogram (ERG) (HP:0000550)1.91818397
72Renal cortical cysts (HP:0000803)1.90691998
73Abnormality of renal resorption (HP:0011038)1.89873492
74Pachygyria (HP:0001302)1.89237967
75Meckel diverticulum (HP:0002245)1.86524048
76Methylmalonic acidemia (HP:0002912)1.85416455
77Asplenia (HP:0001746)1.85216533
78Delayed CNS myelination (HP:0002188)1.82613958
79Colon cancer (HP:0003003)1.82613556
80Methylmalonic aciduria (HP:0012120)1.82219067
81Abnormality of the renal cortex (HP:0011035)1.82170930
82Abnormality of urine glucose concentration (HP:0011016)1.81926836
83Glycosuria (HP:0003076)1.81926836
84Anencephaly (HP:0002323)1.81847789
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.81560653
86Abnormality of the middle phalanges of the toes (HP:0010183)1.81499604
87Absent/shortened dynein arms (HP:0200106)1.81053884
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.81053884
89Decreased central vision (HP:0007663)1.80369716
90Abnormality of the phalanges of the 5th finger (HP:0004213)1.79991849
91Medial flaring of the eyebrow (HP:0010747)1.79166133
92Abnormality of the ileum (HP:0001549)1.76788906
93Ectopic kidney (HP:0000086)1.76650434
94Constricted visual fields (HP:0001133)1.76023319
95Thyroid-stimulating hormone excess (HP:0002925)1.76003889
96Depressed nasal ridge (HP:0000457)1.73504037
97Type I transferrin isoform profile (HP:0003642)1.73276232
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72389026
99Chorioretinal atrophy (HP:0000533)1.72100385
100Poor head control (HP:0002421)1.70741554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.48843258
2TAF13.19937858
3STK163.05923896
4TLK12.62628912
5IRAK42.56036131
6WNK42.50594068
7NME22.28191573
8TIE12.20782375
9ILK2.18875280
10ADRBK22.08466043
11BRAF2.03551860
12PDK22.02626117
13GRK12.02134401
14PLK41.91095187
15BCKDK1.85600579
16PINK11.80836436
17ZAK1.77608922
18TXK1.67357823
19VRK21.62359356
20SRPK11.61997974
21DYRK21.56477667
22NUAK11.40782669
23BMPR1B1.40394363
24MARK31.34753580
25MAP4K21.33294264
26CAMKK21.27808567
27CDK191.25787683
28MAPKAPK31.22244247
29CDC71.22050113
30LRRK21.20306271
31NEK11.15934540
32TAOK31.13651283
33BUB11.09331074
34PIK3CA1.05397943
35WNK31.04905936
36PIK3CG1.04643160
37KDR1.03233949
38STK390.99059429
39VRK10.95083696
40PLK20.92125813
41NME10.90993614
42SGK2230.88524439
43SGK4940.88524439
44PRKCI0.87699822
45INSRR0.87439938
46SGK20.87364099
47TSSK60.85709382
48CAMK10.84974179
49CSNK2A20.83503365
50MAP3K110.83479012
51ADRBK10.80396122
52PRKCG0.80331514
53PIM10.80170166
54MAP3K40.80010568
55RPS6KA50.79513326
56DAPK10.78987717
57RPS6KA40.78724879
58MAP2K70.76119089
59AURKB0.73419560
60PASK0.68941341
61MAPK150.68687615
62AURKA0.68058680
63ABL20.68047748
64MAPK130.67274392
65BCR0.65724630
66PRKCQ0.64712133
67CSNK2A10.62319632
68NTRK20.58858774
69TEC0.58729192
70CSNK1E0.57931366
71MAP2K60.56804890
72PRKACA0.55489642
73PLK10.54749851
74KIT0.54604777
75MATK0.52611106
76CSNK1G30.51732547
77IKBKB0.51723647
78TRIM280.51672237
79EPHA40.51464804
80FRK0.50806798
81TGFBR10.48666312
82OBSCN0.47835914
83PIM20.46837749
84PAK30.45214064
85CSNK1G10.44677415
86DMPK0.43646899
87CAMK2A0.43112651
88PRKCD0.41146650
89CSNK1G20.39580011
90CSNK1A10.39289348
91OXSR10.39219380
92MKNK20.38208801
93MINK10.37583979
94PLK30.34855330
95ITK0.34656156
96DYRK30.34300100
97BTK0.32754866
98SYK0.31241104
99CHEK10.30974113
100CAMKK10.30411102

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.41016050
2Oxidative phosphorylation_Homo sapiens_hsa001904.91612570
3Parkinsons disease_Homo sapiens_hsa050124.05007253
4Proteasome_Homo sapiens_hsa030503.16470951
5Huntingtons disease_Homo sapiens_hsa050162.82745562
6Alzheimers disease_Homo sapiens_hsa050102.65291497
7RNA polymerase_Homo sapiens_hsa030202.57533679
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45334959
9Cardiac muscle contraction_Homo sapiens_hsa042602.37358889
10Protein export_Homo sapiens_hsa030601.95030287
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93939827
12Sulfur relay system_Homo sapiens_hsa041221.92458179
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75005550
14Pyrimidine metabolism_Homo sapiens_hsa002401.73265119
15Asthma_Homo sapiens_hsa053101.70105344
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60912062
17Phototransduction_Homo sapiens_hsa047441.60077007
18Homologous recombination_Homo sapiens_hsa034401.59434867
19Fatty acid elongation_Homo sapiens_hsa000621.53926769
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51789579
21Spliceosome_Homo sapiens_hsa030401.44073113
22One carbon pool by folate_Homo sapiens_hsa006701.40684696
23RNA degradation_Homo sapiens_hsa030181.38565036
24DNA replication_Homo sapiens_hsa030301.35880146
25Mismatch repair_Homo sapiens_hsa034301.33599950
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32721656
27Nucleotide excision repair_Homo sapiens_hsa034201.32255915
28Basal transcription factors_Homo sapiens_hsa030221.31132885
29Autoimmune thyroid disease_Homo sapiens_hsa053201.28833316
30Allograft rejection_Homo sapiens_hsa053301.28161906
31Fanconi anemia pathway_Homo sapiens_hsa034601.26154768
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.25829444
33Nitrogen metabolism_Homo sapiens_hsa009101.13107860
34Purine metabolism_Homo sapiens_hsa002301.09904443
35Regulation of autophagy_Homo sapiens_hsa041401.07871229
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07343573
37Base excision repair_Homo sapiens_hsa034101.05510035
38Sulfur metabolism_Homo sapiens_hsa009201.03452150
39Graft-versus-host disease_Homo sapiens_hsa053321.02221717
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00841523
41Collecting duct acid secretion_Homo sapiens_hsa049660.96815937
42Peroxisome_Homo sapiens_hsa041460.95796124
43RNA transport_Homo sapiens_hsa030130.95590645
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94533316
45Propanoate metabolism_Homo sapiens_hsa006400.92307623
46Linoleic acid metabolism_Homo sapiens_hsa005910.90570916
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90251407
48Primary immunodeficiency_Homo sapiens_hsa053400.84253747
49Nicotine addiction_Homo sapiens_hsa050330.82861234
50Butanoate metabolism_Homo sapiens_hsa006500.79784286
51Caffeine metabolism_Homo sapiens_hsa002320.79624482
52Metabolic pathways_Homo sapiens_hsa011000.74772469
53Type I diabetes mellitus_Homo sapiens_hsa049400.69460101
54Pyruvate metabolism_Homo sapiens_hsa006200.68945037
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67736407
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67389667
57Retinol metabolism_Homo sapiens_hsa008300.66479115
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65677473
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63039199
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.61363626
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61310282
62Vitamin B6 metabolism_Homo sapiens_hsa007500.59765622
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59415967
64Olfactory transduction_Homo sapiens_hsa047400.54707651
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53033197
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51367577
67Systemic lupus erythematosus_Homo sapiens_hsa053220.49069349
68Chemical carcinogenesis_Homo sapiens_hsa052040.48032909
69Steroid biosynthesis_Homo sapiens_hsa001000.47458591
70Rheumatoid arthritis_Homo sapiens_hsa053230.47262980
71Fat digestion and absorption_Homo sapiens_hsa049750.46565414
72Folate biosynthesis_Homo sapiens_hsa007900.46281652
73Arginine and proline metabolism_Homo sapiens_hsa003300.45813105
74Morphine addiction_Homo sapiens_hsa050320.40985801
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38511302
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37811914
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.36606521
78Tryptophan metabolism_Homo sapiens_hsa003800.35974244
79beta-Alanine metabolism_Homo sapiens_hsa004100.35089554
80Arachidonic acid metabolism_Homo sapiens_hsa005900.34892888
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33833790
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.33234192
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29803270
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29795078
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.27672507
86GABAergic synapse_Homo sapiens_hsa047270.23448186
87Hematopoietic cell lineage_Homo sapiens_hsa046400.23375214
88Antigen processing and presentation_Homo sapiens_hsa046120.23045181
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.23019023
90Hedgehog signaling pathway_Homo sapiens_hsa043400.20602615
91Tyrosine metabolism_Homo sapiens_hsa003500.20473170
92Glutathione metabolism_Homo sapiens_hsa004800.20025716
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19674748
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19445084
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18075777
96Basal cell carcinoma_Homo sapiens_hsa052170.17516104
97Taste transduction_Homo sapiens_hsa047420.16817857
98Serotonergic synapse_Homo sapiens_hsa047260.16675918
99Non-homologous end-joining_Homo sapiens_hsa034500.15884093
100Fatty acid biosynthesis_Homo sapiens_hsa000610.15840050

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