NACA3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.98353327
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.98353327
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61092674
4DNA deamination (GO:0045006)5.26742879
5ribosomal small subunit assembly (GO:0000028)5.22858752
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.95331303
7chaperone-mediated protein transport (GO:0072321)4.62529062
8protein neddylation (GO:0045116)4.57909489
9viral transcription (GO:0019083)4.39824768
10respiratory electron transport chain (GO:0022904)4.37731884
11electron transport chain (GO:0022900)4.32708556
12protein complex biogenesis (GO:0070271)4.29404554
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27699061
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.27699061
15NADH dehydrogenase complex assembly (GO:0010257)4.27699061
16translational termination (GO:0006415)4.26921246
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.13853814
18ribosomal large subunit biogenesis (GO:0042273)4.09886398
19proteasome assembly (GO:0043248)4.05888614
20cotranslational protein targeting to membrane (GO:0006613)4.05257175
21maturation of SSU-rRNA (GO:0030490)4.03464425
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.01985145
23protein targeting to ER (GO:0045047)4.01440393
24mitochondrial respiratory chain complex assembly (GO:0033108)4.00725166
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96352100
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96352100
27translational elongation (GO:0006414)3.89070076
28protein localization to endoplasmic reticulum (GO:0070972)3.84169513
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.83238968
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82195641
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.79070857
32ribosomal small subunit biogenesis (GO:0042274)3.72328893
33GTP biosynthetic process (GO:0006183)3.67957124
34translation (GO:0006412)3.66182158
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.60602498
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.59219108
37ATP biosynthetic process (GO:0006754)3.56459735
38cullin deneddylation (GO:0010388)3.55511601
39protein deneddylation (GO:0000338)3.47917978
40translational initiation (GO:0006413)3.38905714
41termination of RNA polymerase III transcription (GO:0006386)3.38745258
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.38745258
43respiratory chain complex IV assembly (GO:0008535)3.34092254
44preassembly of GPI anchor in ER membrane (GO:0016254)3.22652036
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21845361
46hydrogen ion transmembrane transport (GO:1902600)3.20856132
47water-soluble vitamin biosynthetic process (GO:0042364)3.19074438
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.16861938
49platelet dense granule organization (GO:0060155)3.16286945
50protein-cofactor linkage (GO:0018065)3.15181628
51cellular protein complex disassembly (GO:0043624)3.14098452
52viral life cycle (GO:0019058)3.12447185
53regulation of cellular amino acid metabolic process (GO:0006521)3.10958449
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10691599
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08319788
56UTP biosynthetic process (GO:0006228)3.05947672
57protein targeting to mitochondrion (GO:0006626)3.04854684
58behavioral response to nicotine (GO:0035095)3.01876822
59cellular component biogenesis (GO:0044085)3.01722403
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01144216
61GPI anchor biosynthetic process (GO:0006506)3.00897686
62maturation of 5.8S rRNA (GO:0000460)3.00052042
63proton transport (GO:0015992)2.99846372
64GPI anchor metabolic process (GO:0006505)2.97687747
65peptidyl-histidine modification (GO:0018202)2.96955529
66pseudouridine synthesis (GO:0001522)2.95095909
67oxidative phosphorylation (GO:0006119)2.93398206
68hydrogen transport (GO:0006818)2.93261705
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92354249
70guanosine-containing compound biosynthetic process (GO:1901070)2.91319773
71cytochrome complex assembly (GO:0017004)2.90959371
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89747377
73nucleoside triphosphate biosynthetic process (GO:0009142)2.87873674
74rRNA processing (GO:0006364)2.85713212
75UTP metabolic process (GO:0046051)2.85361606
76establishment of protein localization to mitochondrion (GO:0072655)2.84874614
77cytidine deamination (GO:0009972)2.84445833
78cytidine metabolic process (GO:0046087)2.84445833
79cytidine catabolic process (GO:0006216)2.84445833
80metallo-sulfur cluster assembly (GO:0031163)2.84336388
81iron-sulfur cluster assembly (GO:0016226)2.84336388
82base-excision repair, AP site formation (GO:0006285)2.83901257
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83245952
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83073694
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83073694
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83073694
87rRNA metabolic process (GO:0016072)2.80701787
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79743537
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79743537
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76073171
91negative regulation of ligase activity (GO:0051352)2.76073171
92protein localization to mitochondrion (GO:0070585)2.75146215
93CTP metabolic process (GO:0046036)2.72762609
94CTP biosynthetic process (GO:0006241)2.72762609
95ribonucleoprotein complex biogenesis (GO:0022613)2.70735564
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70621578
97tRNA processing (GO:0008033)2.69628055
98deoxyribonucleotide catabolic process (GO:0009264)2.69252335
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67917821
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.67917821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.36128489
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29139497
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67455996
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.63550060
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.26451010
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21999746
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.17898144
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13026374
9VDR_22108803_ChIP-Seq_LS180_Human3.10693171
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.93665683
11VDR_23849224_ChIP-Seq_CD4+_Human2.81350847
12FOXP3_21729870_ChIP-Seq_TREG_Human2.35743372
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.33003855
14ZNF274_21170338_ChIP-Seq_K562_Hela2.27209151
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26526097
16ELK1_19687146_ChIP-ChIP_HELA_Human2.25036399
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24358412
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15732342
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15299426
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.10012448
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03607090
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.99382617
23MYC_18940864_ChIP-ChIP_HL60_Human1.95608775
24IGF1R_20145208_ChIP-Seq_DFB_Human1.80018088
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76580862
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.72683080
27TP53_22573176_ChIP-Seq_HFKS_Human1.70365286
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66923897
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63866004
30EWS_26573619_Chip-Seq_HEK293_Human1.58715152
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57929429
32TTF2_22483619_ChIP-Seq_HELA_Human1.54848065
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54652916
34GABP_19822575_ChIP-Seq_HepG2_Human1.49231076
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.45141554
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43351894
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43102660
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41499924
39DCP1A_22483619_ChIP-Seq_HELA_Human1.40931498
40FUS_26573619_Chip-Seq_HEK293_Human1.35563087
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32081432
42TAF15_26573619_Chip-Seq_HEK293_Human1.31440497
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29565476
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28844784
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.28364645
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26589861
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26188331
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.26188331
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24176945
50AR_20517297_ChIP-Seq_VCAP_Human1.23543590
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23206638
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22861384
53IRF1_19129219_ChIP-ChIP_H3396_Human1.22762283
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21725999
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20192512
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19529236
57EZH2_22144423_ChIP-Seq_EOC_Human1.15771287
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14171512
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13444636
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13066166
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12233357
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11688236
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11354535
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10743796
65GATA3_26560356_Chip-Seq_TH2_Human1.10641047
66XRN2_22483619_ChIP-Seq_HELA_Human1.10596802
67NCOR_22424771_ChIP-Seq_293T_Human1.10451425
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10406151
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09068656
70NANOG_19829295_ChIP-Seq_ESCs_Human1.07963882
71SOX2_19829295_ChIP-Seq_ESCs_Human1.07963882
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07932695
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07682961
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06232009
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06183143
76P300_19829295_ChIP-Seq_ESCs_Human1.05525031
77TAF2_19829295_ChIP-Seq_ESCs_Human1.05205777
78ER_23166858_ChIP-Seq_MCF-7_Human1.05154053
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04759549
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03604749
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02759738
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.01382911
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99875424
84GATA3_21878914_ChIP-Seq_MCF-7_Human0.99808966
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.99313824
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.96161135
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95447492
88ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95207114
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95094301
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94916195
91NANOG_20526341_ChIP-Seq_ESCs_Human0.94553518
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94138005
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93316282
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93282334
95E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92342488
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92197300
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91321712
98MYC_19829295_ChIP-Seq_ESCs_Human0.88689882
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88444635
100CBP_20019798_ChIP-Seq_JUKART_Human0.88444635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.40062510
2MP0001835_abnormal_antigen_presentation2.89538115
3MP0005671_abnormal_response_to2.86753228
4MP0006292_abnormal_olfactory_placode2.68301119
5MP0002837_dystrophic_cardiac_calcinosis2.49189869
6MP0002163_abnormal_gland_morphology2.45984905
7MP0004147_increased_porphyrin_level2.43503839
8MP0005646_abnormal_pituitary_gland2.41861601
9MP0004145_abnormal_muscle_electrophysio2.27014482
10MP0006072_abnormal_retinal_apoptosis2.20119714
11MP0003806_abnormal_nucleotide_metabolis2.17406360
12MP0003646_muscle_fatigue2.11730496
13MP0002102_abnormal_ear_morphology2.08668826
14MP0001529_abnormal_vocalization2.01166702
15MP0000372_irregular_coat_pigmentation2.00555645
16MP0003786_premature_aging1.95791144
17MP0004142_abnormal_muscle_tone1.93221899
18MP0008872_abnormal_physiological_respon1.91849779
19MP0002138_abnormal_hepatobiliary_system1.91317148
20MP0005084_abnormal_gallbladder_morpholo1.77096475
21MP0008877_abnormal_DNA_methylation1.76328839
22MP0001968_abnormal_touch/_nociception1.75510797
23MP0008875_abnormal_xenobiotic_pharmacok1.71961337
24MP0006036_abnormal_mitochondrial_physio1.68716052
25MP0005645_abnormal_hypothalamus_physiol1.67281477
26MP0005379_endocrine/exocrine_gland_phen1.60436954
27MP0001188_hyperpigmentation1.56530347
28MP0005551_abnormal_eye_electrophysiolog1.53228788
29MP0003787_abnormal_imprinting1.53121551
30MP0008995_early_reproductive_senescence1.52933997
31MP0005075_abnormal_melanosome_morpholog1.52629221
32MP0002876_abnormal_thyroid_physiology1.50639889
33MP0005389_reproductive_system_phenotype1.49142092
34MP0002736_abnormal_nociception_after1.48325395
35MP0002148_abnormal_hypersensitivity_rea1.47940884
36MP0009785_altered_susceptibility_to1.47623808
37MP0008058_abnormal_DNA_repair1.45021568
38MP0001905_abnormal_dopamine_level1.41028400
39MP0003186_abnormal_redox_activity1.40418351
40MP0003195_calcinosis1.37952234
41MP0009333_abnormal_splenocyte_physiolog1.37478268
42MP0001919_abnormal_reproductive_system1.35302653
43MP0008789_abnormal_olfactory_epithelium1.34632057
44MP0001800_abnormal_humoral_immune1.34234544
45MP0002160_abnormal_reproductive_system1.27687061
46MP0001873_stomach_inflammation1.24416344
47MP0001986_abnormal_taste_sensitivity1.23530370
48MP0002638_abnormal_pupillary_reflex1.21892895
49MP0006276_abnormal_autonomic_nervous1.18865204
50MP0002272_abnormal_nervous_system1.16817350
51MP0004885_abnormal_endolymph1.15664122
52MP0005253_abnormal_eye_physiology1.14292579
53MP0003567_abnormal_fetal_cardiomyocyte1.13229301
54MP0009764_decreased_sensitivity_to1.13220437
55MP0002095_abnormal_skin_pigmentation1.12654930
56MP0001984_abnormal_olfaction1.09157085
57MP0005000_abnormal_immune_tolerance1.07976522
58MP0002277_abnormal_respiratory_mucosa1.06912504
59MP0009745_abnormal_behavioral_response1.05194022
60MP0000685_abnormal_immune_system1.05098196
61MP0009046_muscle_twitch1.04953584
62MP0001764_abnormal_homeostasis1.04692942
63MP0005387_immune_system_phenotype1.03501770
64MP0001790_abnormal_immune_system1.03501770
65MP0006035_abnormal_mitochondrial_morpho1.03093507
66MP0002723_abnormal_immune_serum1.02918621
67MP0001485_abnormal_pinna_reflex1.01370907
68MP0003880_abnormal_central_pattern0.98597735
69MP0000631_abnormal_neuroendocrine_gland0.97409010
70MP0005636_abnormal_mineral_homeostasis0.96661074
71MP0002006_tumorigenesis0.92724765
72MP0003011_delayed_dark_adaptation0.92666587
73MP0002166_altered_tumor_susceptibility0.90510495
74MP0002420_abnormal_adaptive_immunity0.88830552
75MP0001819_abnormal_immune_cell0.88491463
76MP0002452_abnormal_antigen_presenting0.88218756
77MP0001970_abnormal_pain_threshold0.86408763
78MP0005332_abnormal_amino_acid0.84080611
79MP0005377_hearing/vestibular/ear_phenot0.83573143
80MP0003878_abnormal_ear_physiology0.83573143
81MP0005394_taste/olfaction_phenotype0.83539193
82MP0005499_abnormal_olfactory_system0.83539193
83MP0008007_abnormal_cellular_replicative0.82019803
84MP0001501_abnormal_sleep_pattern0.81094898
85MP0000049_abnormal_middle_ear0.80881726
86MP0002234_abnormal_pharynx_morphology0.79915208
87MP0002733_abnormal_thermal_nociception0.76900481
88MP0008775_abnormal_heart_ventricle0.76435542
89MP0002822_catalepsy0.76397063
90MP0005367_renal/urinary_system_phenotyp0.74179683
91MP0000516_abnormal_urinary_system0.74179683
92MP0001486_abnormal_startle_reflex0.72781629
93MP0002653_abnormal_ependyma_morphology0.72757323
94MP0001293_anophthalmia0.70628732
95MP0005410_abnormal_fertilization0.69862683
96MP0003763_abnormal_thymus_physiology0.68319298
97MP0003866_abnormal_defecation0.66766460
98MP0006082_CNS_inflammation0.65452570
99MP0002735_abnormal_chemical_nociception0.65409832
100MP0001765_abnormal_ion_homeostasis0.65131029

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.17057220
2Abnormal mitochondria in muscle tissue (HP:0008316)4.69868349
3Mitochondrial inheritance (HP:0001427)4.69601984
4Acute encephalopathy (HP:0006846)4.44257071
5Progressive macrocephaly (HP:0004481)4.38875161
6Increased CSF lactate (HP:0002490)4.33125178
73-Methylglutaconic aciduria (HP:0003535)4.23004456
8Hepatocellular necrosis (HP:0001404)4.15871704
9Hepatic necrosis (HP:0002605)3.81133387
10Increased hepatocellular lipid droplets (HP:0006565)3.78765988
11Lipid accumulation in hepatocytes (HP:0006561)3.46663936
12Cerebral edema (HP:0002181)3.45138763
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.31360009
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.31360009
15Renal Fanconi syndrome (HP:0001994)3.28305879
16Increased intramyocellular lipid droplets (HP:0012240)3.20749268
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15641964
18Increased serum lactate (HP:0002151)3.00739787
19Exertional dyspnea (HP:0002875)2.95056377
20Abnormality of midbrain morphology (HP:0002418)2.93718721
21Molar tooth sign on MRI (HP:0002419)2.93718721
22Optic disc pallor (HP:0000543)2.93365257
23Congenital, generalized hypertrichosis (HP:0004540)2.89845821
24Lactic acidosis (HP:0003128)2.87828766
25Pancreatic cysts (HP:0001737)2.85632429
26Abolished electroretinogram (ERG) (HP:0000550)2.83731922
27Methylmalonic acidemia (HP:0002912)2.77019432
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73339066
29Congenital stationary night blindness (HP:0007642)2.73103115
30Abnormal rod and cone electroretinograms (HP:0008323)2.71660120
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63075043
32Abnormality of alanine metabolism (HP:0010916)2.63075043
33Hyperalaninemia (HP:0003348)2.63075043
34Increased muscle lipid content (HP:0009058)2.62850078
35Nephronophthisis (HP:0000090)2.52858339
36Respiratory failure (HP:0002878)2.51841026
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50997360
38IgG deficiency (HP:0004315)2.47907587
39Pancreatic fibrosis (HP:0100732)2.41421973
40True hermaphroditism (HP:0010459)2.40821340
41Elevated erythrocyte sedimentation rate (HP:0003565)2.40627411
42Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38680418
43Abnormality of cells of the erythroid lineage (HP:0012130)2.36997412
44Exercise intolerance (HP:0003546)2.36053429
45Lethargy (HP:0001254)2.34180141
46Absent/shortened dynein arms (HP:0200106)2.33649412
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.33649412
48Methylmalonic aciduria (HP:0012120)2.32587616
49Respiratory difficulties (HP:0002880)2.27995077
50Leukodystrophy (HP:0002415)2.24924013
51Reticulocytopenia (HP:0001896)2.17392679
52Severe combined immunodeficiency (HP:0004430)2.17024109
53Macrocytic anemia (HP:0001972)2.16865208
54Glycosuria (HP:0003076)2.14870771
55Abnormality of urine glucose concentration (HP:0011016)2.14870771
56Hypoproteinemia (HP:0003075)2.14476659
57Stomatitis (HP:0010280)2.14341399
58Aplastic anemia (HP:0001915)2.12809376
59Medial flaring of the eyebrow (HP:0010747)2.12607200
60Abnormal number of erythroid precursors (HP:0012131)2.12333701
61Abnormality of the renal cortex (HP:0011035)2.08957771
62Abnormality of renal resorption (HP:0011038)2.08204671
63Constricted visual fields (HP:0001133)2.07158569
64Decreased central vision (HP:0007663)2.06866291
65Pendular nystagmus (HP:0012043)2.06648721
66Abnormality of B cell number (HP:0010975)2.05023019
67Abnormality of the renal medulla (HP:0100957)2.03538408
68CNS demyelination (HP:0007305)2.02008602
69Attenuation of retinal blood vessels (HP:0007843)2.01821694
70Aplasia/hypoplasia of the uterus (HP:0008684)2.01334161
71Type I transferrin isoform profile (HP:0003642)2.00932006
72Renal cortical cysts (HP:0000803)1.99547389
73B lymphocytopenia (HP:0010976)1.97883797
74Abnormality of the prostate (HP:0008775)1.96539159
75Abnormal protein glycosylation (HP:0012346)1.90185422
76Abnormal glycosylation (HP:0012345)1.90185422
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90185422
78Abnormal protein N-linked glycosylation (HP:0012347)1.90185422
79Type II lissencephaly (HP:0007260)1.89864278
80Hyperglycinemia (HP:0002154)1.89297074
81Type 2 muscle fiber atrophy (HP:0003554)1.89117718
82Abnormal hemoglobin (HP:0011902)1.88079319
83Delayed CNS myelination (HP:0002188)1.87145019
84Generalized aminoaciduria (HP:0002909)1.86946281
85Polydipsia (HP:0001959)1.85407105
86Abnormal drinking behavior (HP:0030082)1.85407105
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83927404
88Pallor (HP:0000980)1.83472024
89Thyroiditis (HP:0100646)1.83255086
90Sclerocornea (HP:0000647)1.82024556
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79079544
92Dicarboxylic aciduria (HP:0003215)1.79079544
93Hyperphosphaturia (HP:0003109)1.78420625
94Abnormality of the anterior horn cell (HP:0006802)1.76345370
95Degeneration of anterior horn cells (HP:0002398)1.76345370
96Absent thumb (HP:0009777)1.75718115
97Abnormality of serum amino acid levels (HP:0003112)1.75299743
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.74657691
99Asplenia (HP:0001746)1.73895033
100Abnormality of the phalanges of the 5th finger (HP:0004213)1.73135878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.44122807
2MAP4K22.81771926
3TXK2.79077697
4TLK12.44421030
5CDK192.28771564
6ADRBK22.27013908
7VRK22.26539334
8WNK42.26486681
9NUAK12.24812679
10TAOK32.17437530
11STK162.15039776
12FRK2.14565300
13ZAK2.13795005
14GRK12.04776632
15NME21.86651180
16EIF2AK31.81115497
17TIE11.77645484
18MAP3K121.77136901
19BMPR1B1.70717527
20TEC1.47164748
21BMPR21.42096209
22PINK11.41842690
23KDR1.37196631
24OXSR11.31846627
25SRPK11.31508062
26CSNK1G31.25872205
27VRK11.21687726
28WNK31.21365349
29KIT1.15809127
30STK391.15619389
31PLK41.14807706
32NEK11.14464286
33CSNK1G21.11178222
34DYRK21.09985881
35ILK1.09817723
36FES1.03622378
37PDK21.03493365
38ITK1.03457055
39ERBB31.02585839
40TRIM281.01147174
41CSNK1G11.00224960
42PHKG10.96342421
43PHKG20.96342421
44INSRR0.95891653
45IKBKB0.95490550
46DAPK10.94744179
47LIMK10.94384200
48CSNK1A1L0.92747522
49SCYL20.92075938
50MAP4K10.89196264
51BUB10.86632845
52EIF2AK10.86239470
53CAMKK20.85872431
54SYK0.80525466
55MYLK0.76542899
56PLK30.76319386
57OBSCN0.75970029
58GRK60.73632752
59MKNK20.72948830
60MUSK0.72583879
61MKNK10.67113829
62DAPK20.66682080
63MAPK130.66340122
64RPS6KA50.65286625
65PRKCQ0.65115708
66BTK0.64340837
67PRKCE0.63944148
68ADRBK10.63921225
69PIK3CA0.63103654
70MAP2K60.62357427
71LCK0.58627148
72NME10.58301550
73JAK30.58224237
74MAP3K40.57878528
75ATR0.57848088
76EIF2AK20.57765784
77TGFBR10.56924218
78PLK20.56225862
79LYN0.56140741
80CSF1R0.55784041
81CSNK2A20.55270725
82TSSK60.54285481
83CDK80.53482701
84MST40.52716612
85FLT30.51743507
86CSNK2A10.51703199
87PIM20.50781232
88TRPM70.50127995
89MAPKAPK50.49324399
90PRKACA0.49287716
91MAP2K70.48453278
92BCR0.47852596
93PRKCG0.47261666
94RPS6KA40.47024583
95MINK10.46834267
96ABL20.46563424
97PLK10.45721293
98IGF1R0.42496047
99TESK20.42411914
100CSNK1A10.42103139

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.12222880
2Oxidative phosphorylation_Homo sapiens_hsa001904.09567947
3Proteasome_Homo sapiens_hsa030503.76346739
4Asthma_Homo sapiens_hsa053103.43981757
5Parkinsons disease_Homo sapiens_hsa050123.42576364
6Protein export_Homo sapiens_hsa030602.83538490
7Allograft rejection_Homo sapiens_hsa053302.68861173
8Autoimmune thyroid disease_Homo sapiens_hsa053202.51245889
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.41635777
10RNA polymerase_Homo sapiens_hsa030202.36820262
11Alzheimers disease_Homo sapiens_hsa050102.26128100
12Graft-versus-host disease_Homo sapiens_hsa053322.24276127
13Type I diabetes mellitus_Homo sapiens_hsa049402.22419235
14Huntingtons disease_Homo sapiens_hsa050162.18713239
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06214219
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93688855
17Cardiac muscle contraction_Homo sapiens_hsa042601.66823757
18RNA degradation_Homo sapiens_hsa030181.62459228
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60578659
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58278960
21Homologous recombination_Homo sapiens_hsa034401.51638522
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48502880
23Primary immunodeficiency_Homo sapiens_hsa053401.48038537
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43940399
25Phototransduction_Homo sapiens_hsa047441.40625721
26One carbon pool by folate_Homo sapiens_hsa006701.39745945
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36780455
28Rheumatoid arthritis_Homo sapiens_hsa053231.32869576
29Pyrimidine metabolism_Homo sapiens_hsa002401.32119725
30Antigen processing and presentation_Homo sapiens_hsa046121.26660337
31Linoleic acid metabolism_Homo sapiens_hsa005911.22162940
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09444692
33Sulfur metabolism_Homo sapiens_hsa009201.07508007
34Propanoate metabolism_Homo sapiens_hsa006401.07363937
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03395432
36Spliceosome_Homo sapiens_hsa030401.01485276
37Purine metabolism_Homo sapiens_hsa002300.99879436
38Peroxisome_Homo sapiens_hsa041460.99782734
39Basal transcription factors_Homo sapiens_hsa030220.98924290
40RNA transport_Homo sapiens_hsa030130.98657851
41Fanconi anemia pathway_Homo sapiens_hsa034600.98456279
42Nucleotide excision repair_Homo sapiens_hsa034200.95597567
43Base excision repair_Homo sapiens_hsa034100.95541999
44Nitrogen metabolism_Homo sapiens_hsa009100.93930800
45Regulation of autophagy_Homo sapiens_hsa041400.91608416
46DNA replication_Homo sapiens_hsa030300.90222525
47Collecting duct acid secretion_Homo sapiens_hsa049660.87004881
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82796877
49Viral myocarditis_Homo sapiens_hsa054160.82064973
50Sulfur relay system_Homo sapiens_hsa041220.81568279
51Mismatch repair_Homo sapiens_hsa034300.81303800
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76495226
53Butanoate metabolism_Homo sapiens_hsa006500.75676076
54Hematopoietic cell lineage_Homo sapiens_hsa046400.75572317
55Arachidonic acid metabolism_Homo sapiens_hsa005900.73790953
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73302925
57Caffeine metabolism_Homo sapiens_hsa002320.72647665
58Tryptophan metabolism_Homo sapiens_hsa003800.71439889
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.69027179
60Metabolic pathways_Homo sapiens_hsa011000.66938206
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65388072
62Olfactory transduction_Homo sapiens_hsa047400.62513095
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61396307
64Ether lipid metabolism_Homo sapiens_hsa005650.60397793
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56451914
66Chemical carcinogenesis_Homo sapiens_hsa052040.53755893
67Non-homologous end-joining_Homo sapiens_hsa034500.53115593
68Systemic lupus erythematosus_Homo sapiens_hsa053220.52917483
69Staphylococcus aureus infection_Homo sapiens_hsa051500.51561475
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50076193
71Retinol metabolism_Homo sapiens_hsa008300.47601037
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.46488508
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45350075
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.44125504
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43715010
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42870499
77Fatty acid elongation_Homo sapiens_hsa000620.41380704
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39496603
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38788251
80Selenocompound metabolism_Homo sapiens_hsa004500.38654870
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38208260
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36876399
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36419201
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34938503
85Leishmaniasis_Homo sapiens_hsa051400.33849304
86Fat digestion and absorption_Homo sapiens_hsa049750.33587155
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33324313
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.33051053
89Nicotine addiction_Homo sapiens_hsa050330.32760730
90Pyruvate metabolism_Homo sapiens_hsa006200.32127575
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31494699
92beta-Alanine metabolism_Homo sapiens_hsa004100.30119285
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28242506
94Folate biosynthesis_Homo sapiens_hsa007900.27134614
95Morphine addiction_Homo sapiens_hsa050320.26512186
96Glutathione metabolism_Homo sapiens_hsa004800.25829060
97Epstein-Barr virus infection_Homo sapiens_hsa051690.24893542
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23694723
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22635008
100Herpes simplex infection_Homo sapiens_hsa051680.21902827

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