

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ATP synthesis coupled proton transport (GO:0015986) | 5.98353327 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.98353327 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.61092674 |
| 4 | DNA deamination (GO:0045006) | 5.26742879 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 5.22858752 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.95331303 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.62529062 |
| 8 | protein neddylation (GO:0045116) | 4.57909489 |
| 9 | viral transcription (GO:0019083) | 4.39824768 |
| 10 | respiratory electron transport chain (GO:0022904) | 4.37731884 |
| 11 | electron transport chain (GO:0022900) | 4.32708556 |
| 12 | protein complex biogenesis (GO:0070271) | 4.29404554 |
| 13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.27699061 |
| 14 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.27699061 |
| 15 | NADH dehydrogenase complex assembly (GO:0010257) | 4.27699061 |
| 16 | translational termination (GO:0006415) | 4.26921246 |
| 17 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.13853814 |
| 18 | ribosomal large subunit biogenesis (GO:0042273) | 4.09886398 |
| 19 | proteasome assembly (GO:0043248) | 4.05888614 |
| 20 | cotranslational protein targeting to membrane (GO:0006613) | 4.05257175 |
| 21 | maturation of SSU-rRNA (GO:0030490) | 4.03464425 |
| 22 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.01985145 |
| 23 | protein targeting to ER (GO:0045047) | 4.01440393 |
| 24 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.00725166 |
| 25 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.96352100 |
| 26 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.96352100 |
| 27 | translational elongation (GO:0006414) | 3.89070076 |
| 28 | protein localization to endoplasmic reticulum (GO:0070972) | 3.84169513 |
| 29 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.83238968 |
| 30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.82195641 |
| 31 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.79070857 |
| 32 | ribosomal small subunit biogenesis (GO:0042274) | 3.72328893 |
| 33 | GTP biosynthetic process (GO:0006183) | 3.67957124 |
| 34 | translation (GO:0006412) | 3.66182158 |
| 35 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.60602498 |
| 36 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.59219108 |
| 37 | ATP biosynthetic process (GO:0006754) | 3.56459735 |
| 38 | cullin deneddylation (GO:0010388) | 3.55511601 |
| 39 | protein deneddylation (GO:0000338) | 3.47917978 |
| 40 | translational initiation (GO:0006413) | 3.38905714 |
| 41 | termination of RNA polymerase III transcription (GO:0006386) | 3.38745258 |
| 42 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.38745258 |
| 43 | respiratory chain complex IV assembly (GO:0008535) | 3.34092254 |
| 44 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.22652036 |
| 45 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.21845361 |
| 46 | hydrogen ion transmembrane transport (GO:1902600) | 3.20856132 |
| 47 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.19074438 |
| 48 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.16861938 |
| 49 | platelet dense granule organization (GO:0060155) | 3.16286945 |
| 50 | protein-cofactor linkage (GO:0018065) | 3.15181628 |
| 51 | cellular protein complex disassembly (GO:0043624) | 3.14098452 |
| 52 | viral life cycle (GO:0019058) | 3.12447185 |
| 53 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.10958449 |
| 54 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.10691599 |
| 55 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.08319788 |
| 56 | UTP biosynthetic process (GO:0006228) | 3.05947672 |
| 57 | protein targeting to mitochondrion (GO:0006626) | 3.04854684 |
| 58 | behavioral response to nicotine (GO:0035095) | 3.01876822 |
| 59 | cellular component biogenesis (GO:0044085) | 3.01722403 |
| 60 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.01144216 |
| 61 | GPI anchor biosynthetic process (GO:0006506) | 3.00897686 |
| 62 | maturation of 5.8S rRNA (GO:0000460) | 3.00052042 |
| 63 | proton transport (GO:0015992) | 2.99846372 |
| 64 | GPI anchor metabolic process (GO:0006505) | 2.97687747 |
| 65 | peptidyl-histidine modification (GO:0018202) | 2.96955529 |
| 66 | pseudouridine synthesis (GO:0001522) | 2.95095909 |
| 67 | oxidative phosphorylation (GO:0006119) | 2.93398206 |
| 68 | hydrogen transport (GO:0006818) | 2.93261705 |
| 69 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.92354249 |
| 70 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.91319773 |
| 71 | cytochrome complex assembly (GO:0017004) | 2.90959371 |
| 72 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.89747377 |
| 73 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.87873674 |
| 74 | rRNA processing (GO:0006364) | 2.85713212 |
| 75 | UTP metabolic process (GO:0046051) | 2.85361606 |
| 76 | establishment of protein localization to mitochondrion (GO:0072655) | 2.84874614 |
| 77 | cytidine deamination (GO:0009972) | 2.84445833 |
| 78 | cytidine metabolic process (GO:0046087) | 2.84445833 |
| 79 | cytidine catabolic process (GO:0006216) | 2.84445833 |
| 80 | metallo-sulfur cluster assembly (GO:0031163) | 2.84336388 |
| 81 | iron-sulfur cluster assembly (GO:0016226) | 2.84336388 |
| 82 | base-excision repair, AP site formation (GO:0006285) | 2.83901257 |
| 83 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.83245952 |
| 84 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.83073694 |
| 85 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.83073694 |
| 86 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.83073694 |
| 87 | rRNA metabolic process (GO:0016072) | 2.80701787 |
| 88 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.79743537 |
| 89 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.79743537 |
| 90 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.76073171 |
| 91 | negative regulation of ligase activity (GO:0051352) | 2.76073171 |
| 92 | protein localization to mitochondrion (GO:0070585) | 2.75146215 |
| 93 | CTP metabolic process (GO:0046036) | 2.72762609 |
| 94 | CTP biosynthetic process (GO:0006241) | 2.72762609 |
| 95 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.70735564 |
| 96 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.70621578 |
| 97 | tRNA processing (GO:0008033) | 2.69628055 |
| 98 | deoxyribonucleotide catabolic process (GO:0009264) | 2.69252335 |
| 99 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.67917821 |
| 100 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.67917821 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.36128489 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.29139497 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.67455996 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.63550060 |
| 5 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.26451010 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.21999746 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.17898144 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.13026374 |
| 9 | VDR_22108803_ChIP-Seq_LS180_Human | 3.10693171 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.93665683 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.81350847 |
| 12 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.35743372 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.33003855 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.27209151 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.26526097 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.25036399 |
| 17 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.24358412 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.15732342 |
| 19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.15299426 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.10012448 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.03607090 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.99382617 |
| 23 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.95608775 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.80018088 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.76580862 |
| 26 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.72683080 |
| 27 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.70365286 |
| 28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.66923897 |
| 29 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.63866004 |
| 30 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58715152 |
| 31 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.57929429 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.54848065 |
| 33 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54652916 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.49231076 |
| 35 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.45141554 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43351894 |
| 37 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.43102660 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.41499924 |
| 39 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.40931498 |
| 40 | FUS_26573619_Chip-Seq_HEK293_Human | 1.35563087 |
| 41 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.32081432 |
| 42 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.31440497 |
| 43 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29565476 |
| 44 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.28844784 |
| 45 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.28364645 |
| 46 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26589861 |
| 47 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.26188331 |
| 48 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.26188331 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.24176945 |
| 50 | AR_20517297_ChIP-Seq_VCAP_Human | 1.23543590 |
| 51 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.23206638 |
| 52 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.22861384 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.22762283 |
| 54 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.21725999 |
| 55 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.20192512 |
| 56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.19529236 |
| 57 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.15771287 |
| 58 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14171512 |
| 59 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.13444636 |
| 60 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.13066166 |
| 61 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12233357 |
| 62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.11688236 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.11354535 |
| 64 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.10743796 |
| 65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.10641047 |
| 66 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.10596802 |
| 67 | NCOR_22424771_ChIP-Seq_293T_Human | 1.10451425 |
| 68 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.10406151 |
| 69 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.09068656 |
| 70 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.07963882 |
| 71 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.07963882 |
| 72 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.07932695 |
| 73 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07682961 |
| 74 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.06232009 |
| 75 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.06183143 |
| 76 | P300_19829295_ChIP-Seq_ESCs_Human | 1.05525031 |
| 77 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.05205777 |
| 78 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05154053 |
| 79 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.04759549 |
| 80 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.03604749 |
| 81 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.02759738 |
| 82 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.01382911 |
| 83 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.99875424 |
| 84 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.99808966 |
| 85 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.99313824 |
| 86 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.96161135 |
| 87 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.95447492 |
| 88 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.95207114 |
| 89 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95094301 |
| 90 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94916195 |
| 91 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.94553518 |
| 92 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.94138005 |
| 93 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.93316282 |
| 94 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.93282334 |
| 95 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.92342488 |
| 96 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.92197300 |
| 97 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91321712 |
| 98 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.88689882 |
| 99 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.88444635 |
| 100 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.88444635 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 3.40062510 |
| 2 | MP0001835_abnormal_antigen_presentation | 2.89538115 |
| 3 | MP0005671_abnormal_response_to | 2.86753228 |
| 4 | MP0006292_abnormal_olfactory_placode | 2.68301119 |
| 5 | MP0002837_dystrophic_cardiac_calcinosis | 2.49189869 |
| 6 | MP0002163_abnormal_gland_morphology | 2.45984905 |
| 7 | MP0004147_increased_porphyrin_level | 2.43503839 |
| 8 | MP0005646_abnormal_pituitary_gland | 2.41861601 |
| 9 | MP0004145_abnormal_muscle_electrophysio | 2.27014482 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.20119714 |
| 11 | MP0003806_abnormal_nucleotide_metabolis | 2.17406360 |
| 12 | MP0003646_muscle_fatigue | 2.11730496 |
| 13 | MP0002102_abnormal_ear_morphology | 2.08668826 |
| 14 | MP0001529_abnormal_vocalization | 2.01166702 |
| 15 | MP0000372_irregular_coat_pigmentation | 2.00555645 |
| 16 | MP0003786_premature_aging | 1.95791144 |
| 17 | MP0004142_abnormal_muscle_tone | 1.93221899 |
| 18 | MP0008872_abnormal_physiological_respon | 1.91849779 |
| 19 | MP0002138_abnormal_hepatobiliary_system | 1.91317148 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.77096475 |
| 21 | MP0008877_abnormal_DNA_methylation | 1.76328839 |
| 22 | MP0001968_abnormal_touch/_nociception | 1.75510797 |
| 23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.71961337 |
| 24 | MP0006036_abnormal_mitochondrial_physio | 1.68716052 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 1.67281477 |
| 26 | MP0005379_endocrine/exocrine_gland_phen | 1.60436954 |
| 27 | MP0001188_hyperpigmentation | 1.56530347 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.53228788 |
| 29 | MP0003787_abnormal_imprinting | 1.53121551 |
| 30 | MP0008995_early_reproductive_senescence | 1.52933997 |
| 31 | MP0005075_abnormal_melanosome_morpholog | 1.52629221 |
| 32 | MP0002876_abnormal_thyroid_physiology | 1.50639889 |
| 33 | MP0005389_reproductive_system_phenotype | 1.49142092 |
| 34 | MP0002736_abnormal_nociception_after | 1.48325395 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 1.47940884 |
| 36 | MP0009785_altered_susceptibility_to | 1.47623808 |
| 37 | MP0008058_abnormal_DNA_repair | 1.45021568 |
| 38 | MP0001905_abnormal_dopamine_level | 1.41028400 |
| 39 | MP0003186_abnormal_redox_activity | 1.40418351 |
| 40 | MP0003195_calcinosis | 1.37952234 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.37478268 |
| 42 | MP0001919_abnormal_reproductive_system | 1.35302653 |
| 43 | MP0008789_abnormal_olfactory_epithelium | 1.34632057 |
| 44 | MP0001800_abnormal_humoral_immune | 1.34234544 |
| 45 | MP0002160_abnormal_reproductive_system | 1.27687061 |
| 46 | MP0001873_stomach_inflammation | 1.24416344 |
| 47 | MP0001986_abnormal_taste_sensitivity | 1.23530370 |
| 48 | MP0002638_abnormal_pupillary_reflex | 1.21892895 |
| 49 | MP0006276_abnormal_autonomic_nervous | 1.18865204 |
| 50 | MP0002272_abnormal_nervous_system | 1.16817350 |
| 51 | MP0004885_abnormal_endolymph | 1.15664122 |
| 52 | MP0005253_abnormal_eye_physiology | 1.14292579 |
| 53 | MP0003567_abnormal_fetal_cardiomyocyte | 1.13229301 |
| 54 | MP0009764_decreased_sensitivity_to | 1.13220437 |
| 55 | MP0002095_abnormal_skin_pigmentation | 1.12654930 |
| 56 | MP0001984_abnormal_olfaction | 1.09157085 |
| 57 | MP0005000_abnormal_immune_tolerance | 1.07976522 |
| 58 | MP0002277_abnormal_respiratory_mucosa | 1.06912504 |
| 59 | MP0009745_abnormal_behavioral_response | 1.05194022 |
| 60 | MP0000685_abnormal_immune_system | 1.05098196 |
| 61 | MP0009046_muscle_twitch | 1.04953584 |
| 62 | MP0001764_abnormal_homeostasis | 1.04692942 |
| 63 | MP0005387_immune_system_phenotype | 1.03501770 |
| 64 | MP0001790_abnormal_immune_system | 1.03501770 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 1.03093507 |
| 66 | MP0002723_abnormal_immune_serum | 1.02918621 |
| 67 | MP0001485_abnormal_pinna_reflex | 1.01370907 |
| 68 | MP0003880_abnormal_central_pattern | 0.98597735 |
| 69 | MP0000631_abnormal_neuroendocrine_gland | 0.97409010 |
| 70 | MP0005636_abnormal_mineral_homeostasis | 0.96661074 |
| 71 | MP0002006_tumorigenesis | 0.92724765 |
| 72 | MP0003011_delayed_dark_adaptation | 0.92666587 |
| 73 | MP0002166_altered_tumor_susceptibility | 0.90510495 |
| 74 | MP0002420_abnormal_adaptive_immunity | 0.88830552 |
| 75 | MP0001819_abnormal_immune_cell | 0.88491463 |
| 76 | MP0002452_abnormal_antigen_presenting | 0.88218756 |
| 77 | MP0001970_abnormal_pain_threshold | 0.86408763 |
| 78 | MP0005332_abnormal_amino_acid | 0.84080611 |
| 79 | MP0005377_hearing/vestibular/ear_phenot | 0.83573143 |
| 80 | MP0003878_abnormal_ear_physiology | 0.83573143 |
| 81 | MP0005394_taste/olfaction_phenotype | 0.83539193 |
| 82 | MP0005499_abnormal_olfactory_system | 0.83539193 |
| 83 | MP0008007_abnormal_cellular_replicative | 0.82019803 |
| 84 | MP0001501_abnormal_sleep_pattern | 0.81094898 |
| 85 | MP0000049_abnormal_middle_ear | 0.80881726 |
| 86 | MP0002234_abnormal_pharynx_morphology | 0.79915208 |
| 87 | MP0002733_abnormal_thermal_nociception | 0.76900481 |
| 88 | MP0008775_abnormal_heart_ventricle | 0.76435542 |
| 89 | MP0002822_catalepsy | 0.76397063 |
| 90 | MP0005367_renal/urinary_system_phenotyp | 0.74179683 |
| 91 | MP0000516_abnormal_urinary_system | 0.74179683 |
| 92 | MP0001486_abnormal_startle_reflex | 0.72781629 |
| 93 | MP0002653_abnormal_ependyma_morphology | 0.72757323 |
| 94 | MP0001293_anophthalmia | 0.70628732 |
| 95 | MP0005410_abnormal_fertilization | 0.69862683 |
| 96 | MP0003763_abnormal_thymus_physiology | 0.68319298 |
| 97 | MP0003866_abnormal_defecation | 0.66766460 |
| 98 | MP0006082_CNS_inflammation | 0.65452570 |
| 99 | MP0002735_abnormal_chemical_nociception | 0.65409832 |
| 100 | MP0001765_abnormal_ion_homeostasis | 0.65131029 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.17057220 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.69868349 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.69601984 |
| 4 | Acute encephalopathy (HP:0006846) | 4.44257071 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.38875161 |
| 6 | Increased CSF lactate (HP:0002490) | 4.33125178 |
| 7 | 3-Methylglutaconic aciduria (HP:0003535) | 4.23004456 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.15871704 |
| 9 | Hepatic necrosis (HP:0002605) | 3.81133387 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.78765988 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.46663936 |
| 12 | Cerebral edema (HP:0002181) | 3.45138763 |
| 13 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.31360009 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.31360009 |
| 15 | Renal Fanconi syndrome (HP:0001994) | 3.28305879 |
| 16 | Increased intramyocellular lipid droplets (HP:0012240) | 3.20749268 |
| 17 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.15641964 |
| 18 | Increased serum lactate (HP:0002151) | 3.00739787 |
| 19 | Exertional dyspnea (HP:0002875) | 2.95056377 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 2.93718721 |
| 21 | Molar tooth sign on MRI (HP:0002419) | 2.93718721 |
| 22 | Optic disc pallor (HP:0000543) | 2.93365257 |
| 23 | Congenital, generalized hypertrichosis (HP:0004540) | 2.89845821 |
| 24 | Lactic acidosis (HP:0003128) | 2.87828766 |
| 25 | Pancreatic cysts (HP:0001737) | 2.85632429 |
| 26 | Abolished electroretinogram (ERG) (HP:0000550) | 2.83731922 |
| 27 | Methylmalonic acidemia (HP:0002912) | 2.77019432 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.73339066 |
| 29 | Congenital stationary night blindness (HP:0007642) | 2.73103115 |
| 30 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.71660120 |
| 31 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.63075043 |
| 32 | Abnormality of alanine metabolism (HP:0010916) | 2.63075043 |
| 33 | Hyperalaninemia (HP:0003348) | 2.63075043 |
| 34 | Increased muscle lipid content (HP:0009058) | 2.62850078 |
| 35 | Nephronophthisis (HP:0000090) | 2.52858339 |
| 36 | Respiratory failure (HP:0002878) | 2.51841026 |
| 37 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.50997360 |
| 38 | IgG deficiency (HP:0004315) | 2.47907587 |
| 39 | Pancreatic fibrosis (HP:0100732) | 2.41421973 |
| 40 | True hermaphroditism (HP:0010459) | 2.40821340 |
| 41 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.40627411 |
| 42 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.38680418 |
| 43 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.36997412 |
| 44 | Exercise intolerance (HP:0003546) | 2.36053429 |
| 45 | Lethargy (HP:0001254) | 2.34180141 |
| 46 | Absent/shortened dynein arms (HP:0200106) | 2.33649412 |
| 47 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.33649412 |
| 48 | Methylmalonic aciduria (HP:0012120) | 2.32587616 |
| 49 | Respiratory difficulties (HP:0002880) | 2.27995077 |
| 50 | Leukodystrophy (HP:0002415) | 2.24924013 |
| 51 | Reticulocytopenia (HP:0001896) | 2.17392679 |
| 52 | Severe combined immunodeficiency (HP:0004430) | 2.17024109 |
| 53 | Macrocytic anemia (HP:0001972) | 2.16865208 |
| 54 | Glycosuria (HP:0003076) | 2.14870771 |
| 55 | Abnormality of urine glucose concentration (HP:0011016) | 2.14870771 |
| 56 | Hypoproteinemia (HP:0003075) | 2.14476659 |
| 57 | Stomatitis (HP:0010280) | 2.14341399 |
| 58 | Aplastic anemia (HP:0001915) | 2.12809376 |
| 59 | Medial flaring of the eyebrow (HP:0010747) | 2.12607200 |
| 60 | Abnormal number of erythroid precursors (HP:0012131) | 2.12333701 |
| 61 | Abnormality of the renal cortex (HP:0011035) | 2.08957771 |
| 62 | Abnormality of renal resorption (HP:0011038) | 2.08204671 |
| 63 | Constricted visual fields (HP:0001133) | 2.07158569 |
| 64 | Decreased central vision (HP:0007663) | 2.06866291 |
| 65 | Pendular nystagmus (HP:0012043) | 2.06648721 |
| 66 | Abnormality of B cell number (HP:0010975) | 2.05023019 |
| 67 | Abnormality of the renal medulla (HP:0100957) | 2.03538408 |
| 68 | CNS demyelination (HP:0007305) | 2.02008602 |
| 69 | Attenuation of retinal blood vessels (HP:0007843) | 2.01821694 |
| 70 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.01334161 |
| 71 | Type I transferrin isoform profile (HP:0003642) | 2.00932006 |
| 72 | Renal cortical cysts (HP:0000803) | 1.99547389 |
| 73 | B lymphocytopenia (HP:0010976) | 1.97883797 |
| 74 | Abnormality of the prostate (HP:0008775) | 1.96539159 |
| 75 | Abnormal protein glycosylation (HP:0012346) | 1.90185422 |
| 76 | Abnormal glycosylation (HP:0012345) | 1.90185422 |
| 77 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.90185422 |
| 78 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.90185422 |
| 79 | Type II lissencephaly (HP:0007260) | 1.89864278 |
| 80 | Hyperglycinemia (HP:0002154) | 1.89297074 |
| 81 | Type 2 muscle fiber atrophy (HP:0003554) | 1.89117718 |
| 82 | Abnormal hemoglobin (HP:0011902) | 1.88079319 |
| 83 | Delayed CNS myelination (HP:0002188) | 1.87145019 |
| 84 | Generalized aminoaciduria (HP:0002909) | 1.86946281 |
| 85 | Polydipsia (HP:0001959) | 1.85407105 |
| 86 | Abnormal drinking behavior (HP:0030082) | 1.85407105 |
| 87 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.83927404 |
| 88 | Pallor (HP:0000980) | 1.83472024 |
| 89 | Thyroiditis (HP:0100646) | 1.83255086 |
| 90 | Sclerocornea (HP:0000647) | 1.82024556 |
| 91 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.79079544 |
| 92 | Dicarboxylic aciduria (HP:0003215) | 1.79079544 |
| 93 | Hyperphosphaturia (HP:0003109) | 1.78420625 |
| 94 | Abnormality of the anterior horn cell (HP:0006802) | 1.76345370 |
| 95 | Degeneration of anterior horn cells (HP:0002398) | 1.76345370 |
| 96 | Absent thumb (HP:0009777) | 1.75718115 |
| 97 | Abnormality of serum amino acid levels (HP:0003112) | 1.75299743 |
| 98 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.74657691 |
| 99 | Asplenia (HP:0001746) | 1.73895033 |
| 100 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.73135878 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 3.44122807 |
| 2 | MAP4K2 | 2.81771926 |
| 3 | TXK | 2.79077697 |
| 4 | TLK1 | 2.44421030 |
| 5 | CDK19 | 2.28771564 |
| 6 | ADRBK2 | 2.27013908 |
| 7 | VRK2 | 2.26539334 |
| 8 | WNK4 | 2.26486681 |
| 9 | NUAK1 | 2.24812679 |
| 10 | TAOK3 | 2.17437530 |
| 11 | STK16 | 2.15039776 |
| 12 | FRK | 2.14565300 |
| 13 | ZAK | 2.13795005 |
| 14 | GRK1 | 2.04776632 |
| 15 | NME2 | 1.86651180 |
| 16 | EIF2AK3 | 1.81115497 |
| 17 | TIE1 | 1.77645484 |
| 18 | MAP3K12 | 1.77136901 |
| 19 | BMPR1B | 1.70717527 |
| 20 | TEC | 1.47164748 |
| 21 | BMPR2 | 1.42096209 |
| 22 | PINK1 | 1.41842690 |
| 23 | KDR | 1.37196631 |
| 24 | OXSR1 | 1.31846627 |
| 25 | SRPK1 | 1.31508062 |
| 26 | CSNK1G3 | 1.25872205 |
| 27 | VRK1 | 1.21687726 |
| 28 | WNK3 | 1.21365349 |
| 29 | KIT | 1.15809127 |
| 30 | STK39 | 1.15619389 |
| 31 | PLK4 | 1.14807706 |
| 32 | NEK1 | 1.14464286 |
| 33 | CSNK1G2 | 1.11178222 |
| 34 | DYRK2 | 1.09985881 |
| 35 | ILK | 1.09817723 |
| 36 | FES | 1.03622378 |
| 37 | PDK2 | 1.03493365 |
| 38 | ITK | 1.03457055 |
| 39 | ERBB3 | 1.02585839 |
| 40 | TRIM28 | 1.01147174 |
| 41 | CSNK1G1 | 1.00224960 |
| 42 | PHKG1 | 0.96342421 |
| 43 | PHKG2 | 0.96342421 |
| 44 | INSRR | 0.95891653 |
| 45 | IKBKB | 0.95490550 |
| 46 | DAPK1 | 0.94744179 |
| 47 | LIMK1 | 0.94384200 |
| 48 | CSNK1A1L | 0.92747522 |
| 49 | SCYL2 | 0.92075938 |
| 50 | MAP4K1 | 0.89196264 |
| 51 | BUB1 | 0.86632845 |
| 52 | EIF2AK1 | 0.86239470 |
| 53 | CAMKK2 | 0.85872431 |
| 54 | SYK | 0.80525466 |
| 55 | MYLK | 0.76542899 |
| 56 | PLK3 | 0.76319386 |
| 57 | OBSCN | 0.75970029 |
| 58 | GRK6 | 0.73632752 |
| 59 | MKNK2 | 0.72948830 |
| 60 | MUSK | 0.72583879 |
| 61 | MKNK1 | 0.67113829 |
| 62 | DAPK2 | 0.66682080 |
| 63 | MAPK13 | 0.66340122 |
| 64 | RPS6KA5 | 0.65286625 |
| 65 | PRKCQ | 0.65115708 |
| 66 | BTK | 0.64340837 |
| 67 | PRKCE | 0.63944148 |
| 68 | ADRBK1 | 0.63921225 |
| 69 | PIK3CA | 0.63103654 |
| 70 | MAP2K6 | 0.62357427 |
| 71 | LCK | 0.58627148 |
| 72 | NME1 | 0.58301550 |
| 73 | JAK3 | 0.58224237 |
| 74 | MAP3K4 | 0.57878528 |
| 75 | ATR | 0.57848088 |
| 76 | EIF2AK2 | 0.57765784 |
| 77 | TGFBR1 | 0.56924218 |
| 78 | PLK2 | 0.56225862 |
| 79 | LYN | 0.56140741 |
| 80 | CSF1R | 0.55784041 |
| 81 | CSNK2A2 | 0.55270725 |
| 82 | TSSK6 | 0.54285481 |
| 83 | CDK8 | 0.53482701 |
| 84 | MST4 | 0.52716612 |
| 85 | FLT3 | 0.51743507 |
| 86 | CSNK2A1 | 0.51703199 |
| 87 | PIM2 | 0.50781232 |
| 88 | TRPM7 | 0.50127995 |
| 89 | MAPKAPK5 | 0.49324399 |
| 90 | PRKACA | 0.49287716 |
| 91 | MAP2K7 | 0.48453278 |
| 92 | BCR | 0.47852596 |
| 93 | PRKCG | 0.47261666 |
| 94 | RPS6KA4 | 0.47024583 |
| 95 | MINK1 | 0.46834267 |
| 96 | ABL2 | 0.46563424 |
| 97 | PLK1 | 0.45721293 |
| 98 | IGF1R | 0.42496047 |
| 99 | TESK2 | 0.42411914 |
| 100 | CSNK1A1 | 0.42103139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.12222880 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.09567947 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.76346739 |
| 4 | Asthma_Homo sapiens_hsa05310 | 3.43981757 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.42576364 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.83538490 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.68861173 |
| 8 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.51245889 |
| 9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.41635777 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.36820262 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.26128100 |
| 12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.24276127 |
| 13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.22419235 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.18713239 |
| 15 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.06214219 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.93688855 |
| 17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.66823757 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.62459228 |
| 19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.60578659 |
| 20 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.58278960 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.51638522 |
| 22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.48502880 |
| 23 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.48038537 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43940399 |
| 25 | Phototransduction_Homo sapiens_hsa04744 | 1.40625721 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.39745945 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.36780455 |
| 28 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.32869576 |
| 29 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32119725 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.26660337 |
| 31 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.22162940 |
| 32 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.09444692 |
| 33 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.07508007 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.07363937 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.03395432 |
| 36 | Spliceosome_Homo sapiens_hsa03040 | 1.01485276 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 0.99879436 |
| 38 | Peroxisome_Homo sapiens_hsa04146 | 0.99782734 |
| 39 | Basal transcription factors_Homo sapiens_hsa03022 | 0.98924290 |
| 40 | RNA transport_Homo sapiens_hsa03013 | 0.98657851 |
| 41 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.98456279 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.95597567 |
| 43 | Base excision repair_Homo sapiens_hsa03410 | 0.95541999 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.93930800 |
| 45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.91608416 |
| 46 | DNA replication_Homo sapiens_hsa03030 | 0.90222525 |
| 47 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.87004881 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.82796877 |
| 49 | Viral myocarditis_Homo sapiens_hsa05416 | 0.82064973 |
| 50 | Sulfur relay system_Homo sapiens_hsa04122 | 0.81568279 |
| 51 | Mismatch repair_Homo sapiens_hsa03430 | 0.81303800 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.76495226 |
| 53 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.75676076 |
| 54 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.75572317 |
| 55 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.73790953 |
| 56 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.73302925 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.72647665 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.71439889 |
| 59 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.69027179 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66938206 |
| 61 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.65388072 |
| 62 | Olfactory transduction_Homo sapiens_hsa04740 | 0.62513095 |
| 63 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.61396307 |
| 64 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.60397793 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56451914 |
| 66 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53755893 |
| 67 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.53115593 |
| 68 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.52917483 |
| 69 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.51561475 |
| 70 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.50076193 |
| 71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47601037 |
| 72 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.46488508 |
| 73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45350075 |
| 74 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44125504 |
| 75 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.43715010 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.42870499 |
| 77 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.41380704 |
| 78 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.39496603 |
| 79 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.38788251 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.38654870 |
| 81 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.38208260 |
| 82 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36876399 |
| 83 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.36419201 |
| 84 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.34938503 |
| 85 | Leishmaniasis_Homo sapiens_hsa05140 | 0.33849304 |
| 86 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33587155 |
| 87 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.33324313 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.33051053 |
| 89 | Nicotine addiction_Homo sapiens_hsa05033 | 0.32760730 |
| 90 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.32127575 |
| 91 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31494699 |
| 92 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30119285 |
| 93 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.28242506 |
| 94 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.27134614 |
| 95 | Morphine addiction_Homo sapiens_hsa05032 | 0.26512186 |
| 96 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.25829060 |
| 97 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.24893542 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.23694723 |
| 99 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.22635008 |
| 100 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.21902827 |

