NACAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.23729528
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08803985
3synaptic vesicle maturation (GO:0016188)4.85561584
4neuron cell-cell adhesion (GO:0007158)4.73625280
5pyrimidine nucleobase catabolic process (GO:0006208)4.71158239
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70277756
7neuron recognition (GO:0008038)4.54852751
8response to pheromone (GO:0019236)4.44107055
9cell migration in hindbrain (GO:0021535)4.42814222
10synaptic vesicle exocytosis (GO:0016079)4.34302480
11vocalization behavior (GO:0071625)4.25973678
12glutamate secretion (GO:0014047)4.22386002
13layer formation in cerebral cortex (GO:0021819)4.17863163
14protein localization to synapse (GO:0035418)4.17265577
15regulation of synaptic vesicle exocytosis (GO:2000300)4.07896369
16neurotransmitter-gated ion channel clustering (GO:0072578)4.06545937
17locomotory exploration behavior (GO:0035641)3.97549564
18auditory behavior (GO:0031223)3.94957551
19positive regulation of synapse maturation (GO:0090129)3.86568183
20neurofilament cytoskeleton organization (GO:0060052)3.85980397
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85336334
22negative regulation of microtubule polymerization (GO:0031115)3.84670578
23axonal fasciculation (GO:0007413)3.84110837
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82366738
25central nervous system myelination (GO:0022010)3.69551701
26axon ensheathment in central nervous system (GO:0032291)3.69551701
27dendrite morphogenesis (GO:0048813)3.67470689
28nucleobase catabolic process (GO:0046113)3.66955062
29neuronal action potential propagation (GO:0019227)3.66588809
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64001699
31regulation of synapse structural plasticity (GO:0051823)3.61253808
32dendritic spine morphogenesis (GO:0060997)3.61063963
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60981226
34cerebellar Purkinje cell differentiation (GO:0021702)3.60881545
35transmission of nerve impulse (GO:0019226)3.58996683
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.53135837
37regulation of synaptic vesicle transport (GO:1902803)3.49773088
38regulation of neuronal synaptic plasticity (GO:0048168)3.44572747
39establishment of mitochondrion localization (GO:0051654)3.42727205
40regulation of glutamate receptor signaling pathway (GO:1900449)3.42435768
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41915895
42detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.40218009
43detection of temperature stimulus involved in sensory perception (GO:0050961)3.40218009
44central nervous system projection neuron axonogenesis (GO:0021952)3.40025538
45exploration behavior (GO:0035640)3.37191920
46neurotransmitter secretion (GO:0007269)3.35893201
47neuronal ion channel clustering (GO:0045161)3.32382172
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29170672
49positive regulation of membrane potential (GO:0045838)3.28730429
50potassium ion homeostasis (GO:0055075)3.28651196
51behavioral response to nicotine (GO:0035095)3.26939549
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26138692
53detection of temperature stimulus (GO:0016048)3.26017006
54membrane hyperpolarization (GO:0060081)3.25226634
55adult walking behavior (GO:0007628)3.24209975
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.23976867
57regulation of neurotransmitter levels (GO:0001505)3.23951024
58membrane depolarization during action potential (GO:0086010)3.19663120
59neuronal action potential (GO:0019228)3.19137561
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18326190
61gamma-aminobutyric acid transport (GO:0015812)3.17963155
62glutamate receptor signaling pathway (GO:0007215)3.15714638
63regulation of synapse maturation (GO:0090128)3.13886974
64positive regulation of synapse assembly (GO:0051965)3.13721445
65mechanosensory behavior (GO:0007638)3.13312852
66regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12628161
67synaptic transmission, glutamatergic (GO:0035249)3.12106407
68L-amino acid import (GO:0043092)3.11943448
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10818198
70axon cargo transport (GO:0008088)3.10563999
71regulation of neurotransmitter transport (GO:0051588)3.10247910
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09629050
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.09471871
74synaptic vesicle endocytosis (GO:0048488)3.08574369
75nerve growth factor signaling pathway (GO:0038180)3.08569789
76negative regulation of axonogenesis (GO:0050771)3.06904365
77cellular potassium ion homeostasis (GO:0030007)3.04494906
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03914407
79substrate-independent telencephalic tangential migration (GO:0021826)3.03791107
80substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.03791107
81axon extension (GO:0048675)3.02632442
82proline transport (GO:0015824)3.02555915
83positive regulation of dendritic spine development (GO:0060999)2.99433492
84mating behavior (GO:0007617)2.97579241
85organelle transport along microtubule (GO:0072384)2.97285648
86neuron-neuron synaptic transmission (GO:0007270)2.97246928
87potassium ion import (GO:0010107)2.96665677
88dendritic spine organization (GO:0097061)2.96352739
89glycine transport (GO:0015816)2.95486137
90cell communication by electrical coupling (GO:0010644)2.94322833
91sodium ion export (GO:0071436)2.93352864
92presynaptic membrane organization (GO:0097090)2.93034751
93hippocampus development (GO:0021766)2.92694191
94regulation of synaptic plasticity (GO:0048167)2.91094738
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89389886
96synapse assembly (GO:0007416)2.87863309
97regulation of synaptic transmission, glutamatergic (GO:0051966)2.87608208
98positive regulation of neurotransmitter transport (GO:0051590)2.87022852
99amino acid import (GO:0043090)2.86840407
100neuromuscular process controlling balance (GO:0050885)2.86752249
101synapse organization (GO:0050808)2.85510316
102neurotransmitter transport (GO:0006836)2.85352076
103establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85108335
104mitochondrion transport along microtubule (GO:0047497)2.85108335
105activation of protein kinase A activity (GO:0034199)2.84035814
106regulation of neurotransmitter secretion (GO:0046928)2.83512186
107presynaptic membrane assembly (GO:0097105)2.83358399
108cerebellar Purkinje cell layer development (GO:0021680)2.83273692
109regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82389508
110cerebellar granule cell differentiation (GO:0021707)2.81901931
111synaptic vesicle docking involved in exocytosis (GO:0016081)2.81171235
112neuromuscular synaptic transmission (GO:0007274)2.80662204
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79346593
114vesicle transport along microtubule (GO:0047496)2.78262356
115membrane depolarization (GO:0051899)2.77362911
116regulation of postsynaptic membrane potential (GO:0060078)2.76997631
117negative regulation of axon extension (GO:0030517)2.74895336
118prepulse inhibition (GO:0060134)2.74755693
119regulation of vesicle fusion (GO:0031338)2.74594716
120establishment of nucleus localization (GO:0040023)2.74210281
121response to auditory stimulus (GO:0010996)2.74194876
122regulation of axonogenesis (GO:0050770)2.73856575
123central nervous system neuron axonogenesis (GO:0021955)2.72890878
124regulation of chemokine-mediated signaling pathway (GO:0070099)2.72474457
125regulation of dendritic spine morphogenesis (GO:0061001)2.72393669
126negative regulation of dendrite development (GO:2000171)2.72232273
127neuromuscular process controlling posture (GO:0050884)2.71961245
128cell differentiation in hindbrain (GO:0021533)2.71638388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34860541
2GBX2_23144817_ChIP-Seq_PC3_Human3.42431475
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00237545
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95642270
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94630080
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93781482
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72803832
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72803832
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.65496175
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61197548
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52336097
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.52228317
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51046681
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.48697067
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47961523
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.45554831
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42592999
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42202093
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41722772
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.30033113
21DROSHA_22980978_ChIP-Seq_HELA_Human2.20912531
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.18690619
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.15077530
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.10130348
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07195608
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.03592586
27TAF15_26573619_Chip-Seq_HEK293_Human2.03545494
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00306832
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88544173
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84370129
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83388645
32AR_21572438_ChIP-Seq_LNCaP_Human1.72507853
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71615649
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64808065
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63909199
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62355997
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60725939
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55078532
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50937612
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.48740919
41IGF1R_20145208_ChIP-Seq_DFB_Human1.48045142
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.45016095
43RNF2_27304074_Chip-Seq_NSC_Mouse1.44485724
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43461552
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42131570
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.40371612
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39969738
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33908747
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30192458
50SMAD4_21799915_ChIP-Seq_A2780_Human1.28608184
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26452176
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.25616028
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25401682
54ZNF274_21170338_ChIP-Seq_K562_Hela1.25082207
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23149040
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20346660
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20218342
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20182554
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19968789
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.18665892
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17977523
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17958617
63KDM2B_26808549_Chip-Seq_K562_Human1.17625203
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14660848
65P300_19829295_ChIP-Seq_ESCs_Human1.12858520
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12720563
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12287749
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09248019
69STAT3_23295773_ChIP-Seq_U87_Human1.08563968
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.08196561
71AR_19668381_ChIP-Seq_PC3_Human1.08011396
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06785360
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.05528504
74AHR_22903824_ChIP-Seq_MCF-7_Human1.04064504
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.03443953
76CTCF_27219007_Chip-Seq_Bcells_Human1.03150032
77SMAD4_21741376_ChIP-Seq_HESCs_Human1.02751410
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01606409
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00308332
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00085717
81* AR_25329375_ChIP-Seq_VCAP_Human0.98844877
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97699147
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.95765583
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94933369
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94912783
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94187460
87* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93461762
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90851665
89VDR_22108803_ChIP-Seq_LS180_Human0.90563341
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90408516
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89431517
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89388821
93TCF4_23295773_ChIP-Seq_U87_Human0.89143975
94OCT4_19829295_ChIP-Seq_ESCs_Human0.87313840
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86287034
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86007191
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85551972
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84280013
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.84156168
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.83771720
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83030819
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83030819
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81922684
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81409691
105RUNX2_22187159_ChIP-Seq_PCA_Human0.81355764
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81339237
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80855073
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80685020
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80468356
110JUN_21703547_ChIP-Seq_K562_Human0.79546848
111ER_23166858_ChIP-Seq_MCF-7_Human0.77946962
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77839110
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.77362627
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76749335
115DPY_21335234_ChIP-Seq_ESCs_Mouse0.76335253
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.75283328
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75034208
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74767446
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.73252986
120NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72774385
121LXR_22292898_ChIP-Seq_THP-1_Human0.71687035
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70296513
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68637578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.91383052
2MP0003880_abnormal_central_pattern4.43481839
3MP0004270_analgesia3.98893357
4MP0002735_abnormal_chemical_nociception3.48387534
5MP0001968_abnormal_touch/_nociception3.37146664
6MP0003635_abnormal_synaptic_transmissio3.30531532
7MP0005423_abnormal_somatic_nervous2.96840307
8MP0002734_abnormal_mechanical_nocicepti2.94807824
9MP0006276_abnormal_autonomic_nervous2.92960541
10MP0000778_abnormal_nervous_system2.86440060
11MP0002733_abnormal_thermal_nociception2.68436860
12MP0009745_abnormal_behavioral_response2.68305904
13MP0002063_abnormal_learning/memory/cond2.66937710
14MP0002064_seizures2.61061336
15MP0002736_abnormal_nociception_after2.60489242
16MP0002272_abnormal_nervous_system2.52143412
17MP0009046_muscle_twitch2.41020712
18MP0004858_abnormal_nervous_system2.40182218
19MP0003123_paternal_imprinting2.39351469
20MP0001970_abnormal_pain_threshold2.38326277
21MP0001486_abnormal_startle_reflex2.29499402
22MP0002184_abnormal_innervation2.26842380
23MP0002572_abnormal_emotion/affect_behav2.20770214
24MP0001440_abnormal_grooming_behavior2.12331904
25MP0003329_amyloid_beta_deposits2.10605236
26MP0000955_abnormal_spinal_cord2.07309545
27MP0004811_abnormal_neuron_physiology1.96211362
28MP0005645_abnormal_hypothalamus_physiol1.92921982
29MP0002067_abnormal_sensory_capabilities1.89328225
30MP0001984_abnormal_olfaction1.88088563
31MP0001529_abnormal_vocalization1.84948439
32MP0003122_maternal_imprinting1.74698337
33MP0002882_abnormal_neuron_morphology1.73808813
34MP0000920_abnormal_myelination1.67812252
35MP0003121_genomic_imprinting1.67495229
36MP0002557_abnormal_social/conspecific_i1.66764577
37MP0004742_abnormal_vestibular_system1.59384576
38MP0008569_lethality_at_weaning1.52571971
39MP0001501_abnormal_sleep_pattern1.52371021
40MP0004924_abnormal_behavior1.51642663
41MP0005386_behavior/neurological_phenoty1.51642663
42MP0004885_abnormal_endolymph1.43871337
43MP0002066_abnormal_motor_capabilities/c1.43549865
44MP0005646_abnormal_pituitary_gland1.41000436
45MP0004142_abnormal_muscle_tone1.39329740
46MP0001502_abnormal_circadian_rhythm1.32380890
47MP0001905_abnormal_dopamine_level1.31097797
48MP0002229_neurodegeneration1.28819366
49MP0003634_abnormal_glial_cell1.27039011
50MP0002822_catalepsy1.23944534
51MP0002152_abnormal_brain_morphology1.23299059
52MP0002752_abnormal_somatic_nervous1.22889862
53MP0005499_abnormal_olfactory_system1.21646488
54MP0005394_taste/olfaction_phenotype1.21646488
55MP0001986_abnormal_taste_sensitivity1.17922902
56MP0002909_abnormal_adrenal_gland1.12249655
57MP0002653_abnormal_ependyma_morphology1.08671828
58MP0005551_abnormal_eye_electrophysiolog1.08564042
59MP0003633_abnormal_nervous_system1.06684669
60MP0003631_nervous_system_phenotype1.05738938
61MP0001299_abnormal_eye_distance/1.03838492
62MP0003632_abnormal_nervous_system1.02457169
63MP0002751_abnormal_autonomic_nervous1.02223556
64MP0006292_abnormal_olfactory_placode0.99314572
65MP0004133_heterotaxia0.98948965
66MP0000569_abnormal_digit_pigmentation0.98092297
67MP0004145_abnormal_muscle_electrophysio0.97949405
68MP0001348_abnormal_lacrimal_gland0.96537992
69MP0002069_abnormal_eating/drinking_beha0.95837078
70MP0008789_abnormal_olfactory_epithelium0.95424576
71MP0008877_abnormal_DNA_methylation0.93887540
72MP0003861_abnormal_nervous_system0.93542561
73MP0000751_myopathy0.92955910
74MP0009780_abnormal_chondrocyte_physiolo0.92762892
75MP0003879_abnormal_hair_cell0.92571747
76MP0003690_abnormal_glial_cell0.90676229
77MP0000604_amyloidosis0.89001753
78MP0001963_abnormal_hearing_physiology0.87675325
79MP0005409_darkened_coat_color0.85481259
80MP0000747_muscle_weakness0.82348891
81MP0003283_abnormal_digestive_organ0.81731940
82MP0001485_abnormal_pinna_reflex0.79417170
83MP0000631_abnormal_neuroendocrine_gland0.78671992
84MP0002638_abnormal_pupillary_reflex0.78154668
85MP0010386_abnormal_urinary_bladder0.76946065
86MP0001188_hyperpigmentation0.76619339
87MP0004130_abnormal_muscle_cell0.76538473
88MP0003137_abnormal_impulse_conducting0.76475675
89MP0004085_abnormal_heartbeat0.74211286
90MP0001270_distended_abdomen0.74146019
91MP0001664_abnormal_digestion0.73911495
92MP0001346_abnormal_lacrimal_gland0.73079069
93MP0001943_abnormal_respiration0.71648398
94MP0003938_abnormal_ear_development0.71545675
95MP0006072_abnormal_retinal_apoptosis0.70289899
96MP0000534_abnormal_ureter_morphology0.65488724
97MP0002081_perinatal_lethality0.62556121
98MP0008961_abnormal_basal_metabolism0.62408420
99MP0000026_abnormal_inner_ear0.62087388
100MP0002090_abnormal_vision0.61609924
101MP0005623_abnormal_meninges_morphology0.60337155
102MP0000566_synostosis0.59750561
103MP0003787_abnormal_imprinting0.59410879
104MP0005195_abnormal_posterior_eye0.59190275
105MP0003942_abnormal_urinary_system0.59160704
106MP0001177_atelectasis0.58210681
107MP0010769_abnormal_survival0.57820916
108MP0005171_absent_coat_pigmentation0.57603608
109MP0010770_preweaning_lethality0.57406959
110MP0002082_postnatal_lethality0.57406959
111MP0008874_decreased_physiological_sensi0.57352663
112MP0003890_abnormal_embryonic-extraembry0.57082111
113MP0003119_abnormal_digestive_system0.55934648
114MP0000049_abnormal_middle_ear0.55735725
115MP0009379_abnormal_foot_pigmentation0.55332092
116MP0010768_mortality/aging0.54202779

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.80576577
2Focal motor seizures (HP:0011153)5.22680762
3Focal seizures (HP:0007359)4.66382611
4Supranuclear gaze palsy (HP:0000605)4.45621634
5Ankle clonus (HP:0011448)4.21636589
6Abnormality of the corticospinal tract (HP:0002492)4.01381796
7Visual hallucinations (HP:0002367)3.78068251
8Action tremor (HP:0002345)3.67631487
9Insidious onset (HP:0003587)3.58137995
10Termporal pattern (HP:0011008)3.58137995
11Limb dystonia (HP:0002451)3.54133634
12Spastic gait (HP:0002064)3.53127892
13Epileptic encephalopathy (HP:0200134)3.50489677
14Progressive cerebellar ataxia (HP:0002073)3.42302541
15Failure to thrive in infancy (HP:0001531)3.25325782
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.24226053
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.24226053
18Neurofibrillary tangles (HP:0002185)3.22702140
19Atonic seizures (HP:0010819)3.20350570
20Polyphagia (HP:0002591)3.15999237
21Diplopia (HP:0000651)3.15815226
22Abnormality of binocular vision (HP:0011514)3.15815226
23Ulnar claw (HP:0001178)3.07783686
24Pheochromocytoma (HP:0002666)3.06772031
25Febrile seizures (HP:0002373)3.05470014
26Urinary urgency (HP:0000012)3.04608730
27Abnormal eating behavior (HP:0100738)3.03665461
28Absence seizures (HP:0002121)2.99707713
29Peripheral hypomyelination (HP:0007182)2.98336156
30Dialeptic seizures (HP:0011146)2.91299853
31Mutism (HP:0002300)2.88613652
32Dysmetria (HP:0001310)2.86479593
33Urinary bladder sphincter dysfunction (HP:0002839)2.85003743
34Truncal ataxia (HP:0002078)2.80185096
35Aplasia/Hypoplasia of the brainstem (HP:0007362)2.79481452
36Hypoplasia of the brainstem (HP:0002365)2.79481452
37Obstructive sleep apnea (HP:0002870)2.75740516
38Onion bulb formation (HP:0003383)2.67105815
39Impaired vibration sensation in the lower limbs (HP:0002166)2.66582422
40Akinesia (HP:0002304)2.65524134
41Cerebral inclusion bodies (HP:0100314)2.63556859
42Generalized tonic-clonic seizures (HP:0002069)2.62171493
43Lower limb muscle weakness (HP:0007340)2.61949229
44Neuroendocrine neoplasm (HP:0100634)2.54609810
45Depression (HP:0000716)2.50976491
46Amyotrophic lateral sclerosis (HP:0007354)2.50580130
47Amblyopia (HP:0000646)2.50334712
48Broad-based gait (HP:0002136)2.49341257
49Torticollis (HP:0000473)2.45918450
50Sleep apnea (HP:0010535)2.45258377
51Insomnia (HP:0100785)2.37022567
52Progressive inability to walk (HP:0002505)2.35879416
53Scanning speech (HP:0002168)2.29703879
54Postural instability (HP:0002172)2.28258238
55Specific learning disability (HP:0001328)2.27922064
56Hemiparesis (HP:0001269)2.27729098
57Dysdiadochokinesis (HP:0002075)2.26286550
58Drooling (HP:0002307)2.26272157
59Excessive salivation (HP:0003781)2.26272157
60Impaired social interactions (HP:0000735)2.24785557
61Abnormal social behavior (HP:0012433)2.24785557
62Status epilepticus (HP:0002133)2.24252170
63Hammertoe (HP:0001765)2.24244610
64Poor eye contact (HP:0000817)2.24076268
65Megalencephaly (HP:0001355)2.23789355
66Exotropia (HP:0000577)2.22598055
67Intention tremor (HP:0002080)2.21749139
68Focal dystonia (HP:0004373)2.21397478
69Spastic tetraplegia (HP:0002510)2.20946308
70Hypomagnesemia (HP:0002917)2.20630610
71Spastic tetraparesis (HP:0001285)2.19535783
72Morphological abnormality of the pyramidal tract (HP:0002062)2.18873826
73Hepatoblastoma (HP:0002884)2.17311677
74Genetic anticipation (HP:0003743)2.17056275
75Hemiplegia (HP:0002301)2.16116655
76Esotropia (HP:0000565)2.15927879
77Anxiety (HP:0000739)2.15642301
78Split foot (HP:0001839)2.14826019
79Clonus (HP:0002169)2.14268669
80Lissencephaly (HP:0001339)2.13584466
81Gaze-evoked nystagmus (HP:0000640)2.12263410
82Anomalous pulmonary venous return (HP:0010772)2.10244928
83Hand muscle atrophy (HP:0009130)2.09402758
84Turricephaly (HP:0000262)2.09001189
85Neoplasm of the heart (HP:0100544)2.07766833
86Craniofacial dystonia (HP:0012179)2.04686555
87Gait imbalance (HP:0002141)2.04538822
88Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.04195028
89Abnormality of magnesium homeostasis (HP:0004921)2.03578939
90Cerebral hypomyelination (HP:0006808)2.01952307
91Foot dorsiflexor weakness (HP:0009027)2.01617578
92EEG with generalized epileptiform discharges (HP:0011198)1.99975177
93Steppage gait (HP:0003376)1.99408937
94Annular pancreas (HP:0001734)1.99259405
95Hypoventilation (HP:0002791)1.96343306
96Hypsarrhythmia (HP:0002521)1.95948695
97Epileptiform EEG discharges (HP:0011182)1.95629290
98Distal sensory impairment (HP:0002936)1.95426983
99Impaired pain sensation (HP:0007328)1.95398092
100Abnormality of pain sensation (HP:0010832)1.95398092
101Abnormality of the foot musculature (HP:0001436)1.93843693
102Sensory axonal neuropathy (HP:0003390)1.93152614
103Poor suck (HP:0002033)1.92110562
104Fetal akinesia sequence (HP:0001989)1.91779841
105Decreased motor nerve conduction velocity (HP:0003431)1.91109450
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90300262
107Overriding aorta (HP:0002623)1.89361779
108Abnormality of the lower motor neuron (HP:0002366)1.88412805
109Hyperventilation (HP:0002883)1.87191608
110Absent speech (HP:0001344)1.86550098
111Segmental peripheral demyelination/remyelination (HP:0003481)1.84790083
112Agitation (HP:0000713)1.84490130
113Anosmia (HP:0000458)1.84072239
114Papilledema (HP:0001085)1.83109437
115Abnormality of the pulmonary veins (HP:0011718)1.82544311
116Hypoplasia of the corpus callosum (HP:0002079)1.82163848
117Aplasia involving bones of the extremities (HP:0009825)1.81871296
118Aplasia involving bones of the upper limbs (HP:0009823)1.81871296
119Aplasia of the phalanges of the hand (HP:0009802)1.81871296
120Paraplegia (HP:0010550)1.81010507
121Incomplete penetrance (HP:0003829)1.80742028
122CNS hypomyelination (HP:0003429)1.79651327
123Bradykinesia (HP:0002067)1.78202016
124Pointed chin (HP:0000307)1.76581062
125Pachygyria (HP:0001302)1.75879489
126Stereotypic behavior (HP:0000733)1.74177106
127Elfin facies (HP:0004428)1.72644216
128Prolonged QT interval (HP:0001657)1.70135927
129Tetraplegia (HP:0002445)1.70026561
130Retinal dysplasia (HP:0007973)1.68869373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.47761992
2MAP3K93.75170324
3MINK13.00393449
4NTRK32.99609008
5PAK62.39467050
6NTRK12.39107671
7NTRK22.30420812
8MAP3K42.27833283
9UHMK12.10691927
10LIMK11.97200665
11BCR1.92032150
12STK391.91814327
13SIK31.82680646
14PHKG21.75525915
15PHKG11.75525915
16MAPK131.74783166
17ICK1.71644978
18EPHA41.70777324
19KSR21.69797894
20TNIK1.68395414
21DYRK21.64201151
22KSR11.61899237
23CDK51.53205351
24MAP3K121.49679484
25MAP2K71.47901758
26OXSR11.44041342
27CASK1.43030287
28PINK11.42426854
29PRPF4B1.42183191
30TYRO31.41965041
31PNCK1.37616894
32FGFR21.33794173
33DAPK21.28941228
34MAP2K41.28058018
35SGK4941.27657181
36SGK2231.27657181
37SIK21.22667943
38CDK191.17051820
39CDK141.16016159
40PAK31.15729829
41CSNK1G21.10579559
42LATS21.09621683
43IRAK21.08658385
44GRK51.08619862
45CDK181.07886945
46PKN11.06216686
47ARAF1.05067884
48LMTK21.03470929
49SGK21.01540488
50WNK31.00986673
51CAMKK11.00275405
52CDK150.98900048
53MAP3K20.98222160
54RET0.98043912
55CSNK1G30.96982688
56WNK10.95918271
57ROCK20.91037118
58RIPK10.90126770
59PRKCG0.89954876
60MARK20.89470582
61CDK11A0.85723033
62CAMK2B0.82564921
63SGK30.82393681
64CSNK1A1L0.81929378
65CAMK2A0.80975266
66CAMKK20.79249488
67CAMK1D0.78052963
68PRKD30.75539992
69WNK40.70542449
70PRKCZ0.70040828
71CAMK40.67678304
72ALK0.63988768
73EPHB10.62500091
74MAP3K130.62243040
75STK110.61650459
76DYRK1A0.60754035
77FYN0.60608967
78BMPR1B0.60035810
79STK380.59537071
80FER0.59330481
81DYRK1B0.58526755
82MAP3K110.58330976
83RPS6KA20.57594937
84ERBB20.57086364
85ROCK10.56790398
86FES0.56670188
87PRKCE0.56210844
88MAPKAPK50.54268369
89CDC42BPA0.53508929
90PLK20.53147538
91CAMK2D0.52593330
92TESK20.52210175
93BRAF0.51819597
94CAMK1G0.51599483
95MAPK120.51214168
96CSNK1G10.51201109
97CAMK2G0.50149214
98BRSK10.49055688
99MAPK100.48045996
100CSNK1E0.46826194
101DDR20.46698535
102SGK10.46473494
103CAMK10.45948558
104EPHB20.45298618
105PRKCH0.44481081
106PRKD10.44324914
107TAOK10.43671831
108MATK0.43418596
109MAP2K10.41444767
110PRKG10.41391715
111NEK60.41059995
112EPHA30.41055144
113PRKACA0.40980936
114RIPK40.40280917
115DAPK30.39409031
116FGR0.38986448
117RPS6KA30.38983928
118DAPK10.38227850
119CSNK1A10.37630346
120MAPK80.36396577
121CSNK1D0.32714124
122PRKAA10.32460219
123PRKCA0.31896052
124SRC0.31453621
125GSK3B0.30596594

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.17292632
2Nicotine addiction_Homo sapiens_hsa050332.86830020
3GABAergic synapse_Homo sapiens_hsa047272.47934186
4Glutamatergic synapse_Homo sapiens_hsa047242.38135277
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35313180
6Olfactory transduction_Homo sapiens_hsa047402.33923168
7Circadian entrainment_Homo sapiens_hsa047132.25505564
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25115270
9Morphine addiction_Homo sapiens_hsa050322.21795992
10Axon guidance_Homo sapiens_hsa043602.18438357
11Dopaminergic synapse_Homo sapiens_hsa047282.08951549
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07046189
13Cholinergic synapse_Homo sapiens_hsa047251.89584344
14Long-term potentiation_Homo sapiens_hsa047201.85173422
15Insulin secretion_Homo sapiens_hsa049111.79285546
16Serotonergic synapse_Homo sapiens_hsa047261.76402554
17Salivary secretion_Homo sapiens_hsa049701.75267486
18Amphetamine addiction_Homo sapiens_hsa050311.66570721
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65557316
20Gap junction_Homo sapiens_hsa045401.62440497
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60909397
22Taste transduction_Homo sapiens_hsa047421.60606394
23Cocaine addiction_Homo sapiens_hsa050301.58303663
24Long-term depression_Homo sapiens_hsa047301.57888515
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51536337
26Gastric acid secretion_Homo sapiens_hsa049711.51380235
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46358260
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38560246
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36231735
30Oxytocin signaling pathway_Homo sapiens_hsa049211.33281576
31GnRH signaling pathway_Homo sapiens_hsa049121.29727397
32Renin secretion_Homo sapiens_hsa049241.29152134
33Collecting duct acid secretion_Homo sapiens_hsa049661.28847481
34ErbB signaling pathway_Homo sapiens_hsa040121.18584705
35Cardiac muscle contraction_Homo sapiens_hsa042601.14615770
36Calcium signaling pathway_Homo sapiens_hsa040201.13134164
37Type II diabetes mellitus_Homo sapiens_hsa049301.10694946
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.09912318
39Phototransduction_Homo sapiens_hsa047441.09104241
40Vibrio cholerae infection_Homo sapiens_hsa051101.05711667
41Steroid biosynthesis_Homo sapiens_hsa001001.02331468
42Dorso-ventral axis formation_Homo sapiens_hsa043201.01953820
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00344134
44Estrogen signaling pathway_Homo sapiens_hsa049150.99508352
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98414006
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97775994
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97048884
48Melanogenesis_Homo sapiens_hsa049160.94856173
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94059692
50cAMP signaling pathway_Homo sapiens_hsa040240.93501756
51Glioma_Homo sapiens_hsa052140.92989227
52Choline metabolism in cancer_Homo sapiens_hsa052310.88691103
53Endocytosis_Homo sapiens_hsa041440.87859749
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.85047040
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84798403
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.80230014
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79941411
58VEGF signaling pathway_Homo sapiens_hsa043700.79671627
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79296201
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78912474
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.75582649
62Renal cell carcinoma_Homo sapiens_hsa052110.74856724
63Oocyte meiosis_Homo sapiens_hsa041140.73893408
64Pancreatic secretion_Homo sapiens_hsa049720.73087705
65MAPK signaling pathway_Homo sapiens_hsa040100.72871731
66Ras signaling pathway_Homo sapiens_hsa040140.71914421
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69658604
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67386497
69Alcoholism_Homo sapiens_hsa050340.65660366
70Hippo signaling pathway_Homo sapiens_hsa043900.64371839
71Dilated cardiomyopathy_Homo sapiens_hsa054140.63024909
72Ether lipid metabolism_Homo sapiens_hsa005650.62956175
73Endometrial cancer_Homo sapiens_hsa052130.62793201
74Thyroid hormone synthesis_Homo sapiens_hsa049180.62648393
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61573889
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59162907
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54931148
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54041763
79Notch signaling pathway_Homo sapiens_hsa043300.53817659
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52563062
81Rap1 signaling pathway_Homo sapiens_hsa040150.52365949
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51573804
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51488461
84Hedgehog signaling pathway_Homo sapiens_hsa043400.51422992
85Alzheimers disease_Homo sapiens_hsa050100.50394764
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50153087
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50059457
88Wnt signaling pathway_Homo sapiens_hsa043100.49887251
89Tight junction_Homo sapiens_hsa045300.49630654
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49164508
91Glucagon signaling pathway_Homo sapiens_hsa049220.48241129
92Insulin signaling pathway_Homo sapiens_hsa049100.48159615
93Phagosome_Homo sapiens_hsa041450.47954458
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.47381803
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46565292
96Basal cell carcinoma_Homo sapiens_hsa052170.45551256
97Bile secretion_Homo sapiens_hsa049760.44825285
98Prion diseases_Homo sapiens_hsa050200.44407041
99Butanoate metabolism_Homo sapiens_hsa006500.44082713
100Colorectal cancer_Homo sapiens_hsa052100.44001519
101mTOR signaling pathway_Homo sapiens_hsa041500.41635088
102Parkinsons disease_Homo sapiens_hsa050120.41522244
103Inositol phosphate metabolism_Homo sapiens_hsa005620.40753369
104AMPK signaling pathway_Homo sapiens_hsa041520.40600549
105Oxidative phosphorylation_Homo sapiens_hsa001900.40338023
106Vitamin B6 metabolism_Homo sapiens_hsa007500.39754216
107Ovarian steroidogenesis_Homo sapiens_hsa049130.39634447
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39308921
109Arginine and proline metabolism_Homo sapiens_hsa003300.38511281
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37381025
111Regulation of autophagy_Homo sapiens_hsa041400.36611034
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34844771
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34808596
114Histidine metabolism_Homo sapiens_hsa003400.32891750
115Circadian rhythm_Homo sapiens_hsa047100.31608335

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