ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.06498980
2	translational termination (GO:0006415)	6.86059408
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.42260423
4	ATP synthesis coupled proton transport (GO:0015986)	6.16642223
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.16642223
6	ribosomal small subunit biogenesis (GO:0042274)	6.16347464
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.07292902
8	cotranslational protein targeting to membrane (GO:0006613)	6.01726097
9	maturation of SSU-rRNA (GO:0030490)	6.00216022
10	protein targeting to ER (GO:0045047)	5.99593977
11	translational elongation (GO:0006414)	5.86573018
12	ribosomal small subunit assembly (GO:0000028)	5.77052470
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.76395848
14	protein localization to endoplasmic reticulum (GO:0070972)	5.62375701
15	viral life cycle (GO:0019058)	5.19426386
16	cellular protein complex disassembly (GO:0043624)	5.17578655
17	water-soluble vitamin biosynthetic process (GO:0042364)	5.14637481
18	chaperone-mediated protein transport (GO:0072321)	4.99660551
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.98179731
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.85351090
21	translational initiation (GO:0006413)	4.81013818
22	ribosomal large subunit biogenesis (GO:0042273)	4.71135604
23	protein complex biogenesis (GO:0070271)	4.67725918
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.60995479
25	respiratory electron transport chain (GO:0022904)	4.47586515
26	electron transport chain (GO:0022900)	4.47496915
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.46279648
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.46279648
29	NADH dehydrogenase complex assembly (GO:0010257)	4.46279648
30	mitochondrial respiratory chain complex assembly (GO:0033108)	4.40721535
31	translation (GO:0006412)	4.33877466
32	DNA deamination (GO:0045006)	4.26569988
33	protein complex disassembly (GO:0043241)	4.23839603
34	macromolecular complex disassembly (GO:0032984)	4.05124151
35	behavioral response to nicotine (GO:0035095)	3.94621758
36	protein targeting to membrane (GO:0006612)	3.85638321
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.85288925
38	termination of RNA polymerase III transcription (GO:0006386)	3.85288925
39	protein neddylation (GO:0045116)	3.82920933
40	ATP biosynthetic process (GO:0006754)	3.77450266
41	protein-cofactor linkage (GO:0018065)	3.69252928
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.65781464
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.55327970
44	proteasome assembly (GO:0043248)	3.54177027
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.51977745
46	cellular component biogenesis (GO:0044085)	3.50650184
47	mRNA catabolic process (GO:0006402)	3.46089646
48	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44131072
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44131072
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.40274022
51	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.38923498
52	intracellular protein transmembrane import (GO:0044743)	3.37648602
53	rRNA modification (GO:0000154)	3.37199053
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.34213224
55	rRNA processing (GO:0006364)	3.33705006
56	hydrogen ion transmembrane transport (GO:1902600)	3.33505887
57	rRNA metabolic process (GO:0016072)	3.29300048
58	respiratory chain complex IV assembly (GO:0008535)	3.27152078
59	maturation of 5.8S rRNA (GO:0000460)	3.21398358
60	rRNA methylation (GO:0031167)	3.17006903
61	cytochrome complex assembly (GO:0017004)	3.16459729
62	RNA catabolic process (GO:0006401)	3.15296075
63	DNA replication checkpoint (GO:0000076)	3.09271506
64	proton transport (GO:0015992)	3.05559333
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.04155149
66	pseudouridine synthesis (GO:0001522)	3.03907199
67	hydrogen transport (GO:0006818)	2.99385414
68	platelet dense granule organization (GO:0060155)	2.85927060
69	protein targeting to mitochondrion (GO:0006626)	2.82668707
70	tRNA processing (GO:0008033)	2.80337561
71	cornea development in camera-type eye (GO:0061303)	2.76846607
72	protein targeting (GO:0006605)	2.76653935
73	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.75710219
74	spliceosomal snRNP assembly (GO:0000387)	2.72541650
75	GTP biosynthetic process (GO:0006183)	2.71314761
76	regulation of mitochondrial translation (GO:0070129)	2.70338129
77	nucleoside triphosphate biosynthetic process (GO:0009142)	2.69724609
78	establishment of protein localization to mitochondrion (GO:0072655)	2.68974507
79	oxidative phosphorylation (GO:0006119)	2.67444949
80	peptidyl-histidine modification (GO:0018202)	2.67129004
81	protein localization to mitochondrion (GO:0070585)	2.66331100
82	intracellular protein transmembrane transport (GO:0065002)	2.60753898
83	establishment of protein localization to membrane (GO:0090150)	2.60545725
84	establishment of protein localization to organelle (GO:0072594)	2.59076807
85	vitamin biosynthetic process (GO:0009110)	2.58092292
86	ncRNA processing (GO:0034470)	2.57427044
87	intra-S DNA damage checkpoint (GO:0031573)	2.56709768
88	spliceosomal complex assembly (GO:0000245)	2.55749772
89	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.51662949
90	cytidine metabolic process (GO:0046087)	2.46435486
91	cytidine catabolic process (GO:0006216)	2.46435486
92	cytidine deamination (GO:0009972)	2.46435486
93	ncRNA metabolic process (GO:0034660)	2.46016143
94	mitochondrial transport (GO:0006839)	2.43148895
95	DNA double-strand break processing (GO:0000729)	2.41814397
96	dopamine transport (GO:0015872)	2.40744092
97	base-excision repair, AP site formation (GO:0006285)	2.40072773
98	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.39893835
99	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.39893835
100	protein K6-linked ubiquitination (GO:0085020)	2.39662299

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.14711920
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.05762259
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.96298704
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.71150266
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.22921012
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.21549730
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.97057087
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.82280574
9	VDR_22108803_ChIP-Seq_LS180_Human	2.69935852
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.65805607
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56147327
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50705698
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.50633383
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.48943805
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.44935045
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.27765676
17	MYC_18940864_ChIP-ChIP_HL60_Human	2.27370902
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.14943818
19	EWS_26573619_Chip-Seq_HEK293_Human	2.10171633
20	FUS_26573619_Chip-Seq_HEK293_Human	2.07930608
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01373118
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98595162
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.93446628
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89554595
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70615609
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69562589
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68933243
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66053181
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65066731
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61280205
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.60915324
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59960387
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56041202
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.51220796
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.51164870
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50513960
37	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.49427567
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.48006113
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47639691
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45366093
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45000874
42	EZH2_22144423_ChIP-Seq_EOC_Human	1.44310182
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42530260
44	P300_19829295_ChIP-Seq_ESCs_Human	1.38233117
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35700609
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.33776399
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32651112
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30191231
49	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.28275487
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27962686
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27904874
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.27250338
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26987653
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26987653
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.23624922
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23544274
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22906161
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21148438
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.20963205
60	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.20200196
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17961244
62	AR_20517297_ChIP-Seq_VCAP_Human	1.15319141
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15314539
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15263988
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15263988
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14795572
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14340251
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10550900
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10037581
70	NCOR_22424771_ChIP-Seq_293T_Human	1.09672989
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07952689
72	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.06508010
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03966423
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99894360
75	CBP_20019798_ChIP-Seq_JUKART_Human	0.97781411
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97781411
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97484103
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96849249
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96118511
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94865320
81	GABP_19822575_ChIP-Seq_HepG2_Human	0.92960054
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92602213
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92423256
84	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.92266128
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92076600
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91800123
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90132515
88	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.89528382
89	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89382017
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88005025
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.86954186
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86700079
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85941130
94	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.85724057
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84193086
96	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.83247871
97	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.82307314
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.81972415
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.81213511
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.80626856

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.24148206
2	MP0006292_abnormal_olfactory_placode	2.80140847
3	MP0006072_abnormal_retinal_apoptosis	2.49763703
4	MP0008877_abnormal_DNA_methylation	2.39098712
5	MP0002837_dystrophic_cardiac_calcinosis	2.26062433
6	MP0004885_abnormal_endolymph	2.24172074
7	MP0002638_abnormal_pupillary_reflex	2.04155729
8	MP0002277_abnormal_respiratory_mucosa	2.03387889
9	MP0002876_abnormal_thyroid_physiology	2.00286087
10	MP0000372_irregular_coat_pigmentation	1.99055502
11	MP0003195_calcinosis	1.93350036
12	MP0002938_white_spotting	1.89032356
13	MP0002163_abnormal_gland_morphology	1.88451209
14	MP0008872_abnormal_physiological_respon	1.84482102
15	MP0002102_abnormal_ear_morphology	1.80905790
16	MP0003806_abnormal_nucleotide_metabolis	1.79431481
17	MP0004142_abnormal_muscle_tone	1.76964323
18	MP0005646_abnormal_pituitary_gland	1.75724858
19	MP0002653_abnormal_ependyma_morphology	1.75339912
20	MP0002160_abnormal_reproductive_system	1.73869303
21	MP0005389_reproductive_system_phenotype	1.68332836
22	MP0005671_abnormal_response_to	1.66780694
23	MP0002234_abnormal_pharynx_morphology	1.64730710
24	MP0001968_abnormal_touch/_nociception	1.63616564
25	MP0001188_hyperpigmentation	1.59369272
26	MP0005551_abnormal_eye_electrophysiolog	1.59026377
27	MP0001905_abnormal_dopamine_level	1.58328736
28	MP0001873_stomach_inflammation	1.57615041
29	MP0005645_abnormal_hypothalamus_physiol	1.55617771
30	MP0000631_abnormal_neuroendocrine_gland	1.54915192
31	MP0002736_abnormal_nociception_after	1.53315737
32	MP0008058_abnormal_DNA_repair	1.52962215
33	MP0002138_abnormal_hepatobiliary_system	1.52367619
34	MP0009046_muscle_twitch	1.52328220
35	MP0005084_abnormal_gallbladder_morpholo	1.51680310
36	MP0004145_abnormal_muscle_electrophysio	1.47296013
37	MP0008875_abnormal_xenobiotic_pharmacok	1.46988775
38	MP0003011_delayed_dark_adaptation	1.46416140
39	MP0001485_abnormal_pinna_reflex	1.46326157
40	MP0004147_increased_porphyrin_level	1.46206785
41	MP0005379_endocrine/exocrine_gland_phen	1.44594707
42	MP0003787_abnormal_imprinting	1.43858067
43	MP0003880_abnormal_central_pattern	1.43794549
44	MP0001919_abnormal_reproductive_system	1.42813018
45	MP0001529_abnormal_vocalization	1.42654429
46	MP0009745_abnormal_behavioral_response	1.42368700
47	MP0006036_abnormal_mitochondrial_physio	1.41947207
48	MP0003718_maternal_effect	1.37162882
49	MP0001986_abnormal_taste_sensitivity	1.35773500
50	MP0002272_abnormal_nervous_system	1.33098647
51	MP0005253_abnormal_eye_physiology	1.32016279
52	MP0000049_abnormal_middle_ear	1.30306764
53	MP0010386_abnormal_urinary_bladder	1.26020556
54	MP0003786_premature_aging	1.24990305
55	MP0002095_abnormal_skin_pigmentation	1.24119823
56	MP0004133_heterotaxia	1.21935712
57	MP0004742_abnormal_vestibular_system	1.18566024
58	MP0005174_abnormal_tail_pigmentation	1.16813091
59	MP0003136_yellow_coat_color	1.11347994
60	MP0003878_abnormal_ear_physiology	1.09964969
61	MP0005377_hearing/vestibular/ear_phenot	1.09964969
62	MP0003315_abnormal_perineum_morphology	1.08565592
63	MP0005075_abnormal_melanosome_morpholog	1.07979139
64	MP0003567_abnormal_fetal_cardiomyocyte	1.07807159
65	MP0006276_abnormal_autonomic_nervous	1.06545365
66	MP0003186_abnormal_redox_activity	1.05854698
67	MP0001764_abnormal_homeostasis	1.00184323
68	MP0008789_abnormal_olfactory_epithelium	0.97432608
69	MP0002822_catalepsy	0.96691265
70	MP0000569_abnormal_digit_pigmentation	0.95948953
71	MP0005332_abnormal_amino_acid	0.95122622
72	MP0008995_early_reproductive_senescence	0.94695330
73	MP0003938_abnormal_ear_development	0.90060216
74	MP0002210_abnormal_sex_determination	0.89970425
75	MP0002557_abnormal_social/conspecific_i	0.89625612
76	MP0009333_abnormal_splenocyte_physiolog	0.88673192
77	MP0003693_abnormal_embryo_hatching	0.86982446
78	MP0002735_abnormal_chemical_nociception	0.86621017
79	MP0002928_abnormal_bile_duct	0.86261336
80	MP0001293_anophthalmia	0.85370157
81	MP0001944_abnormal_pancreas_morphology	0.84440520
82	MP0003283_abnormal_digestive_organ	0.83224225
83	MP0001984_abnormal_olfaction	0.82249767
84	MP0001486_abnormal_startle_reflex	0.81634901
85	MP0010094_abnormal_chromosome_stability	0.79880591
86	MP0005636_abnormal_mineral_homeostasis	0.78173772
87	MP0002693_abnormal_pancreas_physiology	0.77385833
88	MP0000026_abnormal_inner_ear	0.77240447
89	MP0005195_abnormal_posterior_eye	0.75729156
90	MP0000653_abnormal_sex_gland	0.74132414
91	MP0009250_abnormal_appendicular_skeleto	0.73739317
92	MP0002572_abnormal_emotion/affect_behav	0.73458345
93	MP0004215_abnormal_myocardial_fiber	0.72915499
94	MP0000427_abnormal_hair_cycle	0.72866238
95	MP0002064_seizures	0.70641698
96	MP0001929_abnormal_gametogenesis	0.70339215
97	MP0001145_abnormal_male_reproductive	0.69717914
98	MP0003937_abnormal_limbs/digits/tail_de	0.69576755
99	MP0002752_abnormal_somatic_nervous	0.69440916
100	MP0002751_abnormal_autonomic_nervous	0.68912231

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.27111568
2	Acute necrotizing encephalopathy (HP:0006965)	4.26562327
3	Abnormal number of erythroid precursors (HP:0012131)	4.12213868
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.05854950
5	Mitochondrial inheritance (HP:0001427)	4.05667964
6	Increased hepatocellular lipid droplets (HP:0006565)	4.02022390
7	Macrocytic anemia (HP:0001972)	3.89040183
8	Lipid accumulation in hepatocytes (HP:0006561)	3.87926720
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.78793642
10	Increased CSF lactate (HP:0002490)	3.73052312
11	Progressive macrocephaly (HP:0004481)	3.70185010
12	Acute encephalopathy (HP:0006846)	3.58569108
13	Methylmalonic acidemia (HP:0002912)	3.55790131
14	Reticulocytopenia (HP:0001896)	3.47185388
15	Renal Fanconi syndrome (HP:0001994)	3.41276494
16	Congenital, generalized hypertrichosis (HP:0004540)	3.27916372
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.25994339
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.25994339
19	Pancreatic cysts (HP:0001737)	3.21287065
20	Hepatocellular necrosis (HP:0001404)	3.00096199
21	Hepatic necrosis (HP:0002605)	2.99193066
22	Molar tooth sign on MRI (HP:0002419)	2.85320475
23	Abnormality of midbrain morphology (HP:0002418)	2.85320475
24	Methylmalonic aciduria (HP:0012120)	2.82388893
25	Abnormality of alanine metabolism (HP:0010916)	2.80769876
26	Hyperalaninemia (HP:0003348)	2.80769876
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.80769876
28	Pallor (HP:0000980)	2.78189546
29	Exertional dyspnea (HP:0002875)	2.77351352
30	Increased intramyocellular lipid droplets (HP:0012240)	2.74343586
31	Pancreatic fibrosis (HP:0100732)	2.68864359
32	Cerebral edema (HP:0002181)	2.67395477
33	Increased serum lactate (HP:0002151)	2.64323260
34	Congenital stationary night blindness (HP:0007642)	2.64045421
35	Nephronophthisis (HP:0000090)	2.57191275
36	Abnormality of renal resorption (HP:0011038)	2.56198640
37	True hermaphroditism (HP:0010459)	2.56040181
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56018416
39	Lactic acidosis (HP:0003128)	2.55227716
40	Glycosuria (HP:0003076)	2.51843582
41	Abnormality of urine glucose concentration (HP:0011016)	2.51843582
42	Abnormality of the renal cortex (HP:0011035)	2.48018948
43	Increased muscle lipid content (HP:0009058)	2.40378423
44	Renal cortical cysts (HP:0000803)	2.38173797
45	Optic disc pallor (HP:0000543)	2.38155936
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.29226417
47	Medial flaring of the eyebrow (HP:0010747)	2.26791828
48	Respiratory difficulties (HP:0002880)	2.25883754
49	Lethargy (HP:0001254)	2.25171854
50	Abnormality of the renal medulla (HP:0100957)	2.18190135
51	Type II lissencephaly (HP:0007260)	2.15847273
52	Respiratory failure (HP:0002878)	2.15760174
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15632809
54	Abnormality of vitamin B metabolism (HP:0004340)	2.14890906
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12234892
56	Hypothermia (HP:0002045)	2.10345063
57	Abnormality of serum amino acid levels (HP:0003112)	2.10015606
58	Abnormality of methionine metabolism (HP:0010901)	2.08161446
59	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.05786834
60	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.05330881
61	Exercise intolerance (HP:0003546)	2.00769388
62	Type I transferrin isoform profile (HP:0003642)	1.97932636
63	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97442533
64	Pendular nystagmus (HP:0012043)	1.95878227
65	Hypoplasia of the pons (HP:0012110)	1.94888197
66	Abnormal ciliary motility (HP:0012262)	1.94420015
67	Abnormality of the pons (HP:0007361)	1.93683426
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.93253215
69	Abnormal respiratory motile cilium morphology (HP:0005938)	1.93253215
70	IgG deficiency (HP:0004315)	1.92710773
71	Large for gestational age (HP:0001520)	1.92196184
72	Sclerocornea (HP:0000647)	1.91479069
73	Hyperglycinemia (HP:0002154)	1.90285954
74	Generalized aminoaciduria (HP:0002909)	1.89825046
75	Polydipsia (HP:0001959)	1.87380501
76	Abnormal drinking behavior (HP:0030082)	1.87380501
77	Hyperphosphaturia (HP:0003109)	1.86501367
78	Abolished electroretinogram (ERG) (HP:0000550)	1.84725555
79	Colon cancer (HP:0003003)	1.84081031
80	Leukodystrophy (HP:0002415)	1.83044772
81	Homocystinuria (HP:0002156)	1.81920392
82	Abnormality of homocysteine metabolism (HP:0010919)	1.81920392
83	Metabolic acidosis (HP:0001942)	1.81308075
84	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.77391339
85	Absent thumb (HP:0009777)	1.76502841
86	Chronic sinusitis (HP:0011109)	1.74701919
87	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72729568
88	Absent/shortened dynein arms (HP:0200106)	1.72729568
89	Constricted visual fields (HP:0001133)	1.71317260
90	Stenosis of the external auditory canal (HP:0000402)	1.70740430
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69765583
92	Attenuation of retinal blood vessels (HP:0007843)	1.69237522
93	Polyuria (HP:0000103)	1.68630965
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.67892008
95	Dicarboxylic aciduria (HP:0003215)	1.67892008
96	Abnormality of the renal collecting system (HP:0004742)	1.66850629
97	Cystic liver disease (HP:0006706)	1.66043244
98	Abnormal protein N-linked glycosylation (HP:0012347)	1.65958907
99	Abnormal protein glycosylation (HP:0012346)	1.65958907
100	Abnormal glycosylation (HP:0012345)	1.65958907

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.18096294
2	STK16	3.34287247
3	FRK	2.78390643
4	BMPR1B	2.74951390
5	TAOK3	2.62395645
6	ADRBK2	2.52981072
7	VRK2	2.51834057
8	NUAK1	2.48658384
9	CDK19	2.16867945
10	MAP4K2	2.09277191
11	PASK	2.06629131
12	ZAK	2.06134473
13	TXK	2.02240339
14	BUB1	2.01802173
15	GRK1	1.94374192
16	WNK3	1.87050980
17	MST4	1.85711827
18	VRK1	1.79915637
19	TAF1	1.76558846
20	WNK4	1.63371413
21	BCKDK	1.61222928
22	OXSR1	1.46517561
23	INSRR	1.41931683
24	PHKG2	1.30646172
25	PHKG1	1.30646172
26	PDK2	1.28903955
27	PINK1	1.28525025
28	TNIK	1.27986678
29	DYRK2	1.27151883
30	NME1	1.18626512
31	STK39	1.12443059
32	PLK4	1.10589612
33	IKBKB	1.08374188
34	TGFBR1	1.07466733
35	ACVR1B	0.94645702
36	EIF2AK3	0.92436653
37	NME2	0.91107220
38	PLK3	0.90589496
39	MKNK2	0.89892937
40	CASK	0.86532620
41	CSNK1G1	0.84397814
42	TIE1	0.82855084
43	CSNK1G3	0.82405419
44	CSNK1G2	0.82280747
45	PRKCG	0.81093304
46	MAPK13	0.80439738
47	CDK8	0.75372175
48	MKNK1	0.75093471
49	EIF2AK1	0.74187302
50	TEC	0.72107198
51	ADRBK1	0.71276065
52	STK24	0.71093237
53	PIK3CA	0.70231967
54	CDK3	0.68500843
55	SRPK1	0.68363663
56	MUSK	0.68071746
57	CAMKK2	0.66776895
58	MAPK15	0.65320031
59	MAP2K6	0.63794540
60	MAPKAPK5	0.61839813
61	PRKCE	0.61224356
62	MAP3K12	0.60147647
63	PRKCQ	0.60091272
64	CDC7	0.59041140
65	KIT	0.58654752
66	ILK	0.55301528
67	WEE1	0.55042182
68	CSNK2A2	0.54027791
69	PLK2	0.52945516
70	PLK1	0.52908357
71	BRSK2	0.52822387
72	CSNK2A1	0.51988582
73	CSNK1A1L	0.51956093
74	RPS6KA5	0.51202646
75	GRK5	0.50042932
76	ITK	0.49902864
77	PNCK	0.49728558
78	EIF2AK2	0.49550028
79	MAP3K4	0.47832586
80	FGFR2	0.47460459
81	PRKACA	0.45649259
82	TRIM28	0.45422155
83	PAK3	0.44364735
84	NLK	0.44193949
85	STK3	0.43998148
86	CSNK1A1	0.42592130
87	OBSCN	0.41536203
88	GRK6	0.40567847
89	CCNB1	0.40327536
90	MATK	0.38793589
91	CHEK2	0.38251462
92	RPS6KB2	0.37995818
93	SYK	0.37588804
94	PRKCI	0.36929837
95	AURKB	0.35710139
96	MINK1	0.35063760
97	MAP2K2	0.34175327
98	DYRK3	0.32182512
99	PRKCA	0.31701127
100	IKBKE	0.31103645

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.96352008
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.49226506
3	Parkinsons disease_Homo sapiens_hsa05012	3.58692284
4	Protein export_Homo sapiens_hsa03060	3.12491428
5	RNA polymerase_Homo sapiens_hsa03020	2.58949477
6	Proteasome_Homo sapiens_hsa03050	2.51959919
7	Alzheimers disease_Homo sapiens_hsa05010	2.42607394
8	Homologous recombination_Homo sapiens_hsa03440	2.36005278
9	Huntingtons disease_Homo sapiens_hsa05016	2.35771188
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.24467269
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95745914
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94747792
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71428743
14	Basal transcription factors_Homo sapiens_hsa03022	1.69066957
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.61712380
16	RNA degradation_Homo sapiens_hsa03018	1.56164517
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.51057434
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.50729883
19	One carbon pool by folate_Homo sapiens_hsa00670	1.48965828
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.45743032
21	Sulfur relay system_Homo sapiens_hsa04122	1.45034496
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43748818
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.42441464
24	Mismatch repair_Homo sapiens_hsa03430	1.41947910
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.40089083
26	Phototransduction_Homo sapiens_hsa04744	1.36291974
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34942313
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.33443293
29	Asthma_Homo sapiens_hsa05310	1.26143994
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17361415
31	Sulfur metabolism_Homo sapiens_hsa00920	1.14927811
32	Spliceosome_Homo sapiens_hsa03040	1.13927969
33	Caffeine metabolism_Homo sapiens_hsa00232	1.13554715
34	Allograft rejection_Homo sapiens_hsa05330	1.11781667
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.11419256
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10918560
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08066259
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.07959140
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02880833
40	DNA replication_Homo sapiens_hsa03030	1.02734190
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.02307101
42	Nicotine addiction_Homo sapiens_hsa05033	1.00616959
43	Purine metabolism_Homo sapiens_hsa00230	1.00265721
44	Butanoate metabolism_Homo sapiens_hsa00650	0.96937749
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.94834699
46	RNA transport_Homo sapiens_hsa03013	0.91508873
47	Propanoate metabolism_Homo sapiens_hsa00640	0.89956996
48	Peroxisome_Homo sapiens_hsa04146	0.88780184
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88313501
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87987068
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.86475423
52	Retinol metabolism_Homo sapiens_hsa00830	0.84522992
53	Regulation of autophagy_Homo sapiens_hsa04140	0.80862803
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80651357
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79269690
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76501770
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76139355
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.75000090
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.74406542
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70478580
61	Base excision repair_Homo sapiens_hsa03410	0.69102184
62	Metabolic pathways_Homo sapiens_hsa01100	0.68177259
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67840987
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67285615
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66896737
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.65607297
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65601907
68	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63449794
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60730645
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.60601504
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59104006
72	Olfactory transduction_Homo sapiens_hsa04740	0.55086592
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54570142
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52584013
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.50885601
76	Folate biosynthesis_Homo sapiens_hsa00790	0.48985077
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47927292
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45254783
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44909604
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41113334
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40950111
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.39592345
83	Mineral absorption_Homo sapiens_hsa04978	0.39475137
84	Morphine addiction_Homo sapiens_hsa05032	0.37310593
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36876044
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36604888
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.36319931
88	Taste transduction_Homo sapiens_hsa04742	0.35059311
89	Fatty acid degradation_Homo sapiens_hsa00071	0.27400412
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27368785
91	Serotonergic synapse_Homo sapiens_hsa04726	0.25575879
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.25425468
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.25409218
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.22926449
95	Glutathione metabolism_Homo sapiens_hsa00480	0.22675993
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22468161
97	Fatty acid elongation_Homo sapiens_hsa00062	0.21994236
98	p53 signaling pathway_Homo sapiens_hsa04115	0.20340795
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.20273589
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18695889

NACAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »